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# Thiomicrospira denitrificans ATCC 33889, ATCC 33889

>Tmden_1862 conserved hypothetical protein
MKWMRDEEYMELTGLDMSAIDDLAHRGKLTLKVEDGIRYIDPSKGAREVV
PAQLKELSSHNTKEMLVQPQFVEKTIGTIINLHEKVLDAKDETLRAVRVE
NEFLREALSSLQELYDEDRKTIHTLQEQLKLSQQEVEFMRRKYKLMWNKA
IEEHTEK
>Tmden_1458 two component transcriptional regulator, winged helix family
MKILLLEDEVMLNESICEYLDSEGHHVESFFNGLAALEAIKENSYDLLVL
DINVPGIDGLSFLEKIHELKIHVSVIYISALVDIEDISRAYTLGCHDYLK
KPFHLKELSLRVDRIKLSSVVPRVHLRLCKNYSYDQENSTLLFNQEVQIL
TKRQAQIIDLLSRNRGRIVDFEQFQTYVWSEQIVDNATIRAEINRLKKNL
KEDFVINVRGMGYMIDKP
>Tmden_0988 methyl-accepting chemotaxis sensory transducer
MQKLSIKLRFIILISIPIVAVLALAVGRIFYDISIKQNLEVTKERIIEAE
SLSRAVHYLQIERGVSAGFLASKGQNGSSILQSSRQNSDEALNNIRVTYE
KTKSDISMLNNLNELKQKRDAIDSLSISGLDVGAYYTQIVAALIDTVTII
PSLIDDKDNRNTIQTYTHLVFTKESLGQIRALLNRVFSTNKMEIKEFSML
IGRELILKGNKKKFEALASKELRDSYERIFRGEVVKKTFDIIEEAKKRGI
EGDFGIDSNMWFSTVTSTIELLREVEIEIYKSVYTSINKKIEDASNNIII
LLAGLVICTILFIFFILHLIKISIVKPIDIFKNTLLGIGDSRDLTIKMDE
NSPQELSEMASSFNTLIKTIRELIETSKLSSSENASISHELSTTSLRVGT
NVEKSVAVINEAEKKATHIKDEITAATKDAIKSKEEILKANETLAKARDE
IVSLANKVQSSAEVEVELSHRMQTLSHEANEVKSILDIISDIADQTNLLA
LNAAIEAARAGEHGRGFAVVADEVRKLAERTQKSLSEINATINIIVHGII
EVSTQMDSNSKEIQELASSASNVEEMINNSVSIVKGAVTATDKTVNDFEK
TKIDVDSIVSQVSDINDMSSQNARNVEEIAAAAEHLNVMTDELHVKLEMF
KT
>Tmden_1012 response regulator receiver domain protein (CheY-like)
MYKVMIIEDEPLIALDLTKILEKKGFEVTGHVGNFEDAHALFHANKPDII
LSDIKLEDNESGIEVIKELKKISDFSVVYLTSYGDDEIVEKALQTHPVAY
ITKPFKESV
>Tmden_1865 conserved hypothetical protein
MTQEELDALMSGDIDDLDSLGDEQSVSEQNDLEEDEEVDDDDLVFEEEET
KTVKEKPVGYTKKTAHHWPMPATEENKMVHQLDDVTKESEEKASEIFDII
EGVSNNLMDSEEVMNGVVEVINSNIALFKTLNKKFPDVEAFATQLEKNSA
ALDDANQIIESMQSGGDSIMSVMDIMQYQDIHRQKIERVINVMRALSNYM
NSLFEGRIDDEKRVSSAQHIVGDTHNELASNEDIEALLASFVKQ
>Tmden_0269 methyl-accepting chemotaxis sensory transducer
MTIGKRVTILVIGISFALLVSSFFVLNYFKAAIVQNVYSDMRSTLTAKIE
DRMNAKFDIGVTNAVAMANNSDIIASLKNNDRALAAKTLESIGDTYKEQT
DFKNIKIHIHDKDVKSFLRNWQVDKFGDDLSSFRHTINKVKESKKSMAAI
EVGRNGLTIRGLVPVIADNSYLGSLEFMQGFESVVKQFLKEKEYLLVLMD
NKLLNVADLSNTKNRISNYTLSQKTIDDKFLLEAKTIDMEAVLRDGYFVD
KNYFYTYTYIKDFENKPIGIYLLAKDRPSIEKAIDGASSIINSALLLVAS
LIFIITIAILVTIKKIVLNPLNVFQEGLLEFFKYLNKQSNKAELIAIDTN
DEIGKMAKIVNENILKTKENIELDQDLINDVKRVVMEVERGNLNQEVTKS
TQNQALFELKDSLNKMLYSLKNSVAKDINSLVAVLDSFKNSDFRATLEND
EAKVSQAINSIGQTIRDMLRDSNTNADELTRTSVSLIERMQTLAEGSYKQ
ASMLKDISKTMELANSSVVEVSQMTKAVVIKSTDIKSVVNVISEIADQTN
LLALNAAIEAARAGEHGRGFAVVADEVRKLAENTQRSLDDININIESLTQ
AVVDIGTTIEEQVKDINMATDSIKVIDKTTQEHAIHTKEIENIAIKLDEM
SKKTLQSISTKKF
>Tmden_0247 two component transcriptional regulator, winged helix family
MLETLKDKSILFLEDNLEFAQNTIVLLNIFIKTIYHVVTISQAKAILKSR
HVDIIICDIKLKNENGLDFIKEIRSSDLLTPIMIISGHKDESFLFRAIPL
YLSAYLLKPIKYEELIEALQICSEKIIINSKEKINLKDGWCFDTKLCILK
KDEEEYALNKKEAQFMKLIAYNSERLITKEMLHESVWEFEDMSDSAVTNF
MLRIRRRFGKNFIYTIPDLGFRFNIH
>Tmden_0663 histidine kinase
MFSQRSIRQSFLIQLIIASASLIIIFSSLLYFYIEKSIIDEKHEELSVYA
KNASSNESIYGSDVPTAEEYLGLNIEIMYLNTQHLTLDFYETTKNKKSFL
TLIHPFNFDDLSYLKITKDITQTRTLLNKIFNYLLVINVAGFLLVIIYAI
GLSKMLVSPVKTLSNKLSNMNEHLMRPIIVEELPEEFEPLGATINHLILR
IQNFVKYQKELFIGTAHELKTPLAVIKLKNQVTLIKKRTPEEYIEALKVT
NKTVDEMNIIVSNILNIGRQEGMQLEKPQEVDVIAILKQKADDFNLLAAN
EGKTLEMNFQPNGFMAILQVGLLNQIVQNFLQNALKFTQKNKKVLLQSSL
NSYGLLIEVIDEGCGIDESSDLYAPFKREGNKPGVGLGLFLAKSGADALG
AKINIKNRTDGVSGTVASLNLNSKLSCILPSK
>Tmden_0891 response regulator receiver sensor signal transduction histidine kinase
MDEKQTILIVDDKEENIGTLNKLLQKYNLLSASDDKDAIEILFGENEIDL
ILLNITMLKSDGCEVCKTLKNSPKTYHIPIIFLSSKHTQEDIQKGFDAGG
VDYISKPFHPDELLSRVSTHLALRAYEKNLECRVQEEIQKNKFKEQMMYQ
QSKQAALGELLMHISYQWKQPLASLLSITKKNRQKILSLDSFDKDDFLES
LKKSKDILEFMSETIDTFQNFYKPSYDTKEFSLSDTILEILTIVEGTFYF
DDIKIYIISHERDTVFGNQNEFSQVVFTILNNAREIFKLRDTINPEIHIS
VNNKKVSISDNGGGIRGESFDNIFSYDNDMNNELHLGLYLSKILVEKNGG
VITAANSKNGATFTIEFLTWM
>Tmden_1512 cyclic nucleotide-binding domain (cNMP-BD) protein
MNEKLNYIKELSFFNSLDDEKLKIIDSISKITTYAKNSILYYENDTNNKI
FFLVSGLIKVYKIDKFGNEIFLYYIYKDSLISELTTLSSDMIYCFSNAEP
VEESIILEVDFSEFKKEFLSKNILNNEFINEILTKTHQLHCVVNRELVFD
ATAKVAFTLCNDLKMFNSLKRHEISFMLHIQPETLSRVLNKLKRNSIIDI
ENSNVIILNKEMLKSAYKGNM
>Tmden_1178 methyl-accepting chemotaxis sensory transducer
MLSTIKSRIIITILLFGTLAVGLMYFYISYTFNDFSNKTANKSLDMLSQS
IFQTVTQSMLAGDPKVVQNTVQEAKKIHGIEALDVSKSKLTLELYARENE
TFTNDAMIREVLESKKAKIIEKTESSHHTIELLKPMVAEQNCIACHANAK
EGDALGVMSLTVSLDANDTEIRDTKNILLITLSTVFIIFILIINTFFKKE
VIAPIDELRKRIRALVDGDKDLTRRIEVLRKNEFAASAYAVNDFVTTVQD
TVNEVKSLGRENVSIADKITKSSSSIFQTIQEESAIVLETTHKSKSIKDI
LDNSILIAKETQEKVLQADRNLESSKEALSELVHEVDTFIEIENDLSLKL
LGLKHDADQVKSVLLVIKDIAEQTNLLALNAAIEAARAGEHGRGFAVVAD
EVRKLAERTQRSLVEIEMSVSTIVQSINDVSDKMHENAKGMEKLTNISHN
VEDKINDTSYEMKNSVAVARRSVEDSQMMVKHTDEIIFQINEINNHSSLN
KQRVTSITDESKRLLEVANSLESRINEFKS
>Tmden_1296 putative transcriptional regulator, Crp/Fnr family
MLLKETLSSLDFFSSLNDEELELIASFSIATTYDKEYIVHYEKTQSTSLL
FLLEGVAKAYKIDKHNNEIFLHYIYAPSLISDVSSYKKETLISFSNVSLI
EDSKILNIDYKKFKEHFLAKGHLCQEFANEVILKSQQLQSLINREFIFTS
VAKVATMLHDDLDMFNSLKRSEISLILNIQPETLSRVLNRLKRDNIIDSK
HTKITILNKEALLGVYEE
>Tmden_1127 HPP
MRLRNYFNRMKTKDIRPSRKPLTKIIWSVVGAFIGIYVMSIFSNLFSAKD
SFFLLGSFGASAVLVYGAPEVHFSQPRNLIGGHIISAFISVFLVKMLGDV
LSLEILCSLSVALSVLAMHLTLTMHPPGGATALLYVIGSEHIQSLGWLYP
FTPIGLGTLMMLVIALVVNNMSNNSKRHYPLYWY
>Tmden_0009 two component transcriptional regulator, winged helix family
MEILKSYNAIIVDDDKNISSNMFKLLKLYFKEVHSFEDAESAFEFIQENS
VSIIISDIELPGMNELKFAKKVKEFDESIEILILTSFATLEYLKEAASLH
LIDYLEKPISLDKLESILQICAQKLKKNLHYNILISKNIIINFYKKELSV
KEEVHKLSHRESSLLEILLHDKGKVVSKEFLMQELWQDTEGTNAALRNLL
LRLRKKLGDKKIIQNHQNYGYYIE
>Tmden_1257 response regulator receiver (CheY-like) modulated CheW protein
MSVLDNVDAATNLAKNNEVQLLVFRVGDKPDSTYYAINVFKTREVVESKN
HYITQIPSSHWLLEGTIVLRGLQIPILNLPLWLGVTLTKEEIKRSNILVC
DFNGVVIGLRIMSAFRVIKKNWSQMHAPDSYRVGNDNVVINDTRLEDGSL
CLVLDYEKLLADVIPHAMVDVTESPVNLKSLTIPIKLKNGTVLIAEDSKT
AQKHLKQIFENANLSMKIFDNGKLLVDYVDSLEENASKIPAIITDIEMPE
MSGFTVVKLLKNNPLTRNIPIIVNSSMTGQNNKREAEVLGADGFVDKTKS
QNIIPLIVEIMSKDEA
>Tmden_0316 histidine kinase
MFKSLRLKLLFYFFIINFIVLFIYGGFIYSTAKKGLLNTTDAQLKMISLD
VIPDFKESSYSNAKGFADELLGEFSITPLFLKIIHYNKQSKTIEHESISS
DDMSYLFEIPLNEIGHLNSIYYFNKGIYRVSSMLIFEKEDSKFFIQLATK
KDIDSAYIKQLLYNLIIATPIILIIFLFIANILINKTLSPVKEVIESVKL
ISVKSLSNRIDTKKIPSEIEELVSTFNHLLSNLEDSFNKITSFSQDASHE
LKTPLTVIRGEIEVALKQERSTEEYKDILKDILEESINIQEIINQLLFLA
KKDTSEIKSGFLEIYLDEIVTDTALWIEKFAKNKNIDIVIKKIIPSTIYA
NETLLKIAINNILKNAIVYSKSDTTIEISMDETSQEYLLIIKDNGYGISD
EDLPFIFDRFYRADKARSRKDAGFGLGLSIVKMILDIHNYKIKLQSRKDI
GTTVTILIPKNELLLTRNI
>Tmden_0625 two component transcriptional regulator, winged helix family
MSKILFLEDDLLFAETLIDLLEENNMEVVHVPNGQAALDRTFKEKFNLYL
LDINVPLVDGVTLLRELRESDDDTPAIFLTSHKEKEVLKKGFLCGADDFI
TKPFDADELILRILAIIKRAKKEDVTCIGLLCNDDTHKRFLYDNKEIELS
KKEYQLLRLLIKHANNTVPKEMIIDTLWSSSEGGSDGALRVYINRIKQLV
PQINIENIRGVGYKLVS
>Tmden_1895 diguanylate cyclase (GGDEF domain)
MREQVEKMILNRQKTTLATAFAIANDKSLAEGISSNSIENSSYDELISKF
IENELYKNSWMQILDKDLQSIYVSSNGQNGAVSNQNREDLLEASTLKKPL
ISVSIGEGDFGIRAIVPIIKNSALVGLVELSSRFDAISKQMKDIGVDSIV
VLSKEYKNTLKNHLSKNFIDDYYVANIDASVVLMEYLRKNGVHNYIHTPQ
KFENHYIISTYPLKNIQNIVIGHYIMFKKRDDVLNINLDFFMYKWIGIAI
VAFMIMMAVLGSFLHYRNKKQKMYYKNIIDSSSNIVMVVDKDNIINMNKT
FFKYFNDYDTLEAFKAEHQSISDFFVKEEGCIYKDMDGVNWLEYLIKNPK
NSLVKILYNEKEYYFTVGVSLISEEDAHYSAIFSNITDEKIYQKELEHTN
ITDPLTKIRNRYCYNKQIKKECASSNRYFYPLSLVIFDMDNFKNINDNYG
HDVGDKVLIEYTKLITTCLRDSDIFCRIGGEEFALILPHVNKSDAYKLAD
KIRSKVQEHNQIVAITMSFGVTEYKKDEDLELTFKRADKALYEAKNAGRN
RVVAI
>Tmden_0985 histidine kinase
MNSSYLEISYECLSSIGNSFEIESMMSEVVITFYRETKALYCGYYEDESV
DIPMVSFGQDEELAYDVSRGECILKDTQDYFLIILSLKKGYLKLLYMKDI
DIENIYNLLCKFKRKINFALSACEGVKELEELNEKLEERVFESVKKIREH
EEMLLLQSKSAIMGEMLEMIAHQWRQPLTSIGMISNNMLFNIIISEENEL
DKEIFKNELEDINKQIKYLSSTIDDFRGFFKESKEKEKVLIEDILQKSIS
LTKKQLEQNSIEIEVINTCSNLVINTYKNELTQVLLNLMYNAKDAFESQD
IRDKKIILECFLRDENLIIELKDNAGGIDKDIMTKIFQPYFSTKKEKNGT
GLGLYMSRIILQRHLAADISVRNENGGAVFSISMPIKDEIKVRS
>Tmden_0219 multi-sensor hybrid histidine kinase
MKKTFIIISFLFTSLYAHESVKFGVFAYKGVEQTRKQYEPLVKALNEKLD
KKIILEVLTQQEINEKISKKELDIVTTNPTHFLSIRDKYALSGAIATLNG
YDKGVITNKLAGVIIVRPESEIKNLKDIKNKIIAAPSKSHMGGYRAQAYE
LFLAGVDISKKSKKIIEMKGSHQEVVKAVLTGVIDVGFIRDGILEEMIYK
KEISEGDIRVVNEQKGVDYPYKISTKLYPEWPVFSLPHLEEEIVKDFIAA
LFSLKPNDEMKKNGIYNYTLPADYLQVEELSRTLRLPPFDKAIDVTFMDI
LNSHKIELIIIFISLLLGLFYHLRERRRKNFISSLLSNIGEGVYGIDNNG
NCTWINKKALNMLGYSEKEILHKNQHDIFHSHKPSREKYNADECPINLTS
KDKVTRTLNEHFIKKDGSLLPIILTVTSIDEGGAIVVFRDISNSIAKEQA
LKRSERELRLEKQRLDAIIQGTNVGTGEWNIQTGDTIFNERWAEIIGYTL
DEISPTSIDTWEKFSHPDDFIATKKLLEEHLDGKTEYFESEMRMKHKNGH
WVWVVDRAKVFEWDKDGKPVLMSGTHQDITERKLAQEKIEHINNQLESLL
ESIPDLIWMKDVNGVYITCNKRFEDFFGASLDEIKGKTDYDFVSKELADF
FREHDKKAMHSNVPLTNFEEITFAVDSHKEFLQTTKTAVRGRNGEILGIL
GIGRDLSELKRSEQKLRDSKELLDLFFKQSMHGFFFMMLDEPIEWNDSID
KEKTLDYVFEHQRVTKINEAMLEQYKAKEEEFLGFTPTDFFKHNIEEGRD
IWRELFSRGIYHVNTNEQKFDGTPMVIDGDYICLYNSEGKITGHFGVQRE
ITQDIRDKEALQEAKEEAERANNSKSEFLANMSHEIRTPMNAIIGFSEIL
LESDLDEKQLHQLHKINSSSKMLLSIINDILDFSKIEANRLEIEHREFNL
ESILSKIKMLFKQTALDKGLEFYCNVEEGVPSMVVADELRITQVLINLLG
NAIKFTKEGAVKVDLKISKKDEKSATLLFSVIDSGIGISQNQIEKLFKPF
SQADDSITRRYGGSGLGLSISSRLVSAMGGEIDVKSKEGVGSTFSFEIIV
GVNSWSQNSLKLENMDISKDASKLLKYPDFSNVKLLLVEDNEINQEITTE
ILKKVKITPDLANNGKEAVDIFVAKPNYYDIILMDIQMPIMSGYEATKII
REHDKEIPIIALTAAAMIEDRHKTLDAGMNDHLSKPIDSNEMFSSIAKWL
DIDFTIKQKSSNTKVKDSAVLDLEYAINELNLNSDILHKILSKFYEELES
DFASLVELLHVEDKSAKSLIHALKGVSSNIGAKELASIATYIDTQLKKAQ
AIKPEDIALLKEAIERVKEKIVSYLRENPLQEDEMREEDFKNLYLEVSQD
IKNGTMVEFQNQQLLFNLLKTKVNRHELELWMREMDNFDYDKAYNIMKEW
QL
>Tmden_1962 diguanylate cyclase (GGDEF domain)
MIYDFSALFKDDTEAILDEFLDKCTTCIEVDSEHSVSMSVFSNHYRAILN
TFESNFEEEYILDLFEKVAKYESSFKTPYIVIMNELFSLKHILLAKIAQG
GEHLYISQMLMLFKNISNRVAKVYLDEYIDLVLSLNNLRRISISDLVEKK
TIRFYEDHLAWLTKLAQSIKEKNLDIFPELEATDCSFGKWLHNDGKNTIH
NNSKYSAINTLHNNLHRFAQKIFMRMHTQEHDILITYLEKCELISLSIGT
ELAMIDNVLMNQQITKDSLTSALNRNSLKNIFESQYELSFATGNHFILAM
CDLDFFKNINDTYGHVAGDKILINFVKIVKKNIRNSDIIIRYGGEEFIII
LPAVDKEKGCQVLEKIRKDFQESKLHFEGKEIQATLSVGTMEIKPEYHYK
KSFLDEYIMQVDQKLYLAKRNGRNRVESC
>Tmden_0283 methyl-accepting chemotaxis sensory transducer
MFFSKNSDKNRTKELEDEISSLKESLAFYKEIAKFSQEEMLIVFAADGST
LFQNEKALSQIKDSSALYKELQKSSSTISLNDCSGKVVSKKTDDNSAYMY
RITKTDMRDTRESDILTLHQKAITAALTDTQKTFSQMLEELKVMKSESVE
VANDSKDGLFLIQQSAQAMDKLSQNTQLNITGMDSLNQRSGEISTVITLI
QDIADQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAEKTQSATKDIS
LVVKAMQQETNEAQTNTNEVNNIVIDTKVKIEDVSLKIKSFEENASRSQY
EVEHISDKIFASLAKIDHVIYKHNVYALIFGEENNFKSTSHTECRLGKWY
SSGIGKDNFSKMPSYAKLETPHAIVHEQANLLASECGEDKVVCSKEIIEK
RIHAIERASDDVFKYLDALVEEKAKEMMHLAAKTLFKTGEKK
>Tmden_0008 histidine kinase
MKLLFILLFLLTNIFAATTINISQINDGIKTAPFQELSLIDTKLPSIDLA
FSNELHWIQSKKSFFGWINKIAVVKFTLFNDSNETRTLFLRHARLGTDNI
DFWVLKEKKVINHWFMGDRLPLAQRPIQSINSAVKITIQPKEELQIVSQI
TTSGVLDTNYEIFFEKTFLTQSKWQVVWWSIFSGVMLMLVLYNIVNFFGL
KEKSFLIHSLYVIFVTINNLGIYGFLYYLNLTDDYKLVDTMLYTTMPLAL
IFHILYPIFLFSLKEKTPKLTYILITISIIYGLIGSYFIFGYWNQDILKN
AKYILVSATAIWIVIFLVSIYIISKNYTGSLFYFLSQIFVIFRVIYLVLI
LNSDSISMGLQAAMLSSFFVIMEALFITIGMSYRINKELKEKEFHQNIAK
LYERYIYMGSYTSNIIHQWKSPLNHLGTLVTLLKAYNDKNIEINKEEYQS
QLKELETITENLTKISAEVYGYLSNTSSTEPLNIKELITNVFRYFEKDIQ
HVEIQNIDRDVYITANRATLSQILLVLISNSLNIFKQRDIKNPKIEFFIT
KEVDGSYKFYVKDNGGGVDKKISHKIFCPYITTTNGLGSGLFVAKKLVTD
KLSGNLILQNDKNELGGATFVICAKDSYSL
>Tmden_0984 response regulator receiver (CheY-like) modulated diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains)
MDLNLIKQIRLFGSSITVLYVEDEESIRKQVRKTLLNLFDSVDVAIDGVD
ALRMHKEKHYDLIITDLKMPNMDGVELCKKLVEINKDQYIVLISAHKESD
EVLKLLNIGVSGFLLKPIDMPIMLEKLHSVVKNIYANKMMKYHYEQIEKD
ILQNTASSQEELENRDSLTSLYNQKYLLKIINNDVMKWAILININDFKLI
NDYYSYAHGNHLLFQIAELLREEAKEHGYGLFRLSNDEFILLRDEAPSSC
EEIKEEAIQISRTLDKRRYTLIGVDNISVGVTMGIANSEHHLLENLHRSL
IHAKRYGLRYALHRDVPDDRDSVKNIIEVKELLKNSIEKDLIIPVYQPIV
MKDKKFKYEVLMRIRNSLEGGELLSPALFLEIAKNHSYYNEISQMVIFKA
IDKMLADKDVVFSINFSYADMKNKQLLQKLEDSIVKNALGDRLVFEIVES
DQLDNIAIVQGFIARFKEFGVQIAIDDFGSGYSNFAHIFLLKPDFIKIDA
SLIKEMLNNSDMHIFVETIITFAHKLGVEVVAEHVSSKELYDALFELGID
AMQGYYLGYPSEII
>Tmden_0935 transcriptional regulator, LytR/AlgR family
MKILIVDDEELARKRLIRMLLTLKYTEVQEAWDADEAREIFKKDSFDIVF
LDINMPRVSGIELGYELKYLNPDVGIIFQTAYEEHALKAFDIGAVAYLVK
PYSIEQLQGSIRRIKAPLIQKREFKILSKFGDSYLLLKPQEIYYVKADLS
EVMLRTSKGFSYYGEKISNLHVKLESFGFIQIHRSYLINSNEIKDIQTIE
QSKLRFSFKNSSDTIESSKDGAKAFREKFAFL
>Tmden_1041 diguanylate cyclase (GGDEF domain) with PAS/PAC sensor
MQKISKIVILILFLIGGTLFLFNNFINNYNNEIEKTQYKIDGIEFAQKIQ
KFILKIQKLRGYSQFDQFSVDDAGYKSILNSVELIKADAKKDIQDIRALK
ELYPSLYDGGYDYVIDDVKLIMDSSSEDKIVMYQKYTYAIEELKEKAYYL
GFKSKLLLEADGDKYFFVEIMLKHLPNLIEVIGKIRAKTSKAILDESADN
ELLYTIKNNCLLCEEHIKLIYKTINEIHDDVEKTRLLSQLENISSETQKM
QEYVKNTVLLHDAKIEALEFFKISTNVIDKMFILYSINAEFLNQKLNKKL
DELKKTKLYGTIIGAFVVLLIFITIASMVRSYMLYAKSEKKIKNNLTSII
NLKNDLEKCKTIEEIASSSLYFFANKFGVIQGAIYIFDEENNKLYLASSY
ATNKMKPIVELGEGIIGEVGVQKKIIHTDLNDDKKIKFRMEAITAEPSNI
CTIPLISYDKIFGVLQLGFLKKHENIHNEDFAYFIDMIIGFLRDAKYLDT
NKEYIELIDKYVITSKTNKKGIITEVSDAFTKISGYSKKEIIGKSHSIVA
HPDTPKELYKNMWEIILSGKIYKGEIKNLNKSGAEYWIETTITPKTDKYS
NILGFSAIIRDITDKKRIEEYSITDALTGLYNRRFFDTNFNKEYKISKRD
NKNLVLLIIDIDYFKQYNDYYGHQKGDEILKLVSLSMKSLFKRANDYVYR
LGGEEFGISFYTNDKESALKRAESLRKNIEHLKIEHASSEISGYLSISIG
ISFIPKECAMEVNEIYNITDKALYRAKNKGRNRVEEASISL
>Tmden_0972 methyl-accepting chemotaxis sensory transducer
MKMTFTQKLSMIIAVLVIVAIAIAWSGLSGASSLNDSITNLTKVEAKKLN
EMGIVARNSESCRKNEKNIILSKSVDSINSYANIIHNDRQEMDKLLIGLK
DLMVKAENRSRIETLLSDLKKYDEFISEIKALSIASLGESAEALEAQRKS
IELSATKGLEYGEAVSTNVNTILKNNQDNLNEIDAQTTKDYENLRNLNIG
IAVGGIALALIIALFMVRQMMALISSSVTNVSEGAEQVASASNQISSSSQ
QLAEGAQEQAASVEEITSSLTEIKATIEQNSENAREADMLGKDANEAAKM
GYEHIRELSTSMVEINDSSRKISNIIKTIDEIAFQTNLLALNAAVEAARA
GEHGLGFAVVAEEVRNLAQRSATAAKDTAAIIEKSIDDVRKGNQITEQTN
KAFVEILDKVKKTGDIVGEIAIASKEQATGINQLSEAMSQVDSVTQVIAS
NSEESAAASEEMSAQATTMKITIGDLAGIFGIATSSTHSTKSVLHHQQKP
TLGSNTKQNRKAPLVVATKKPSEVLPLDDDDLREF
>Tmden_1680 putative CheA signal transduction histidine kinases, no good domain identification
MGARSDLDSTFDYEIVDEFLEHYSMMVDSMDIMIIDLSKPNMYEQSIDEL
FRVFHNIKSASSYLKISQMAKLAAFVEDALENIRTNHSSANEETINWLLE
ISDMFNAWKNDLTLDKELSRIKFSLLKLPDLENN
>Tmden_0971 CheW protein
MAITQKTNKTKLALSSAQKYLSFEINEEMYAVEILDVKEIIAMMKFTKVP
KMPTFVKGVINLRGLVIPIIDIRVKFELSEIEYNERTTIIIGIVEDSLIG
FIVDKTADVLNITQEEMAPPPKFGTAIDTTFLKSMAKTANGVVMIVNLMK
IFSESELNSVKQIEKIQEI
>Tmden_1940 MCP methyltransferase, CheR-type
MFFNFFKKDTSFEPEHKREQIQDYDDISQIANFFKNETGVTFDKQESILK
NKVTTFCKHKEIFSFHELLDSLNRNSTLKQELIDTLTTNETFFYREFKQV
QELVELVKKCSHKVEILCAPSATGEEPYSIAIALLEAGVASESFNILGID
INQEAIQRAKNGVYKERNIRNLSSEQLRKYFKQEGGLYRLNDSVKSRVTF
RVINIFDHSFKNIGNFDFIFCRNMLIYFDKETKIKAKEILQNLRKNKNQE
IFFGHADLF
>Tmden_0977 CheD, stimulates methylation of MCP proteins
MEYEKKYIHSSQLFVAVRPSVIQTVLGSCVAVCLYDSKMQISGMNHYLLP
LWNNDGLASPKYGNIAISKLIEAMEAVGCQRRDMVAKLFGGASPNNFNAQ
NGMLVGEKNIQIAHHILSEQRIKIVASDLGGTRGRKISLESNSGRVMLKY
VQKTEF
>Tmden_0314 protein tyrosine phosphatase
MNKKILVLCTGNSCRSIIAEALINAHVKGVRAYSAGVRASGVVNPNAKAV
LQKAQIWRDEYHSKTIEEIEDIDFDLVITVCDNAKESCPIFKKKSKVIHV
GFVDPDGKEIAEFFKIFDEIKSKLLPIIEKEL
>Tmden_1675 conserved hypothetical protein
MTASDIQNFSNGRTKARAYFCYLFSKNIQNRMPSLTQEMAMIGLLKTKED
LEKCEGVYLLDDRGVQVSPTFTLTKRVDEDVGRIRAERAYYYRAVKEGRC
TITDPYPSLITGDLTVTISQPIYDDKGELKYVACLDMPLEEVVKISRSTM
LDKFFLSLFRYSYAAFAFALISVALLLFIKGAQSFFLYEISPEHFQIKDV
FEATILLTLALAIFDLAKTLIEEEILGRSKDSSISGPHKTMVRFLGSIII
ALSIEALMLVFKFAITDPEKILYAMYIILGVSMLLITLAFYIKFTKLKIE
E
>Tmden_1365 two component transcriptional regulator, winged helix family
MKILYLEDDITLCDTIAEYLIEEGFDVKAVYDGEEALEQVYKESFDLFLF
DVNVPKINGFKLLHELRGANILTPTIFTTSLQGINDLSMGYESGADDYIK
KPFALKELLFRIKALLKREFKSQNFIIKIEDGVKFNTFTNELYIRERKTA
LNPKETLLLKLLLKHQNECVLLEDIYSELWTHDEPYSDMSLRTYIKNLRK
LIGKEMIISIKKVGYKLVQ
>Tmden_0976 histidine kinase
MNLGEVTNEMLLEEIQKRFLERDLIIADSKKMLKKLEDVNKRLTKSEENR
SKFMSIIKNEFNNPIFSMISLSKSLLKSSSDEKVSFIGESLYEESLMLNF
QIKNIITAAEIEAGTIPIESSKIDFLDILLQIKEELKYPLQHKKIDLQTK
ISSDDIIYLDREKLYLILLNLISNAVEFSPVDSKVIVEISEENNYIKLVV
QDFGEGIDESDYENIFKRFHQAHSGMNRAHRGQGLGLSVVRDLVDLLDGE
VHFESTLFKSTRFEITLAKSLKSDENLFGDDDFLFVSDSAGEEF
>Tmden_1570 diguanylate cyclase (GGDEF domain)
MNIQTIIKQSIKRLELEGKLLTPDFYAEAFCKEAAKAGYNVEDCTKLDKF
KLMLNKDLQEELKKYHTKTISEFSHFLISKLNRTIPSHCSNLLESQIQFT
KRVLQTIEVLHNKEASELSIKCFDLLSREPSPAEIDQYRQLWVNFLTTYD
DTFLQNLKPLGDVDSKDLKKTIENLNIQNLPIGKSETFELSKVASLLVAS
LVPSIASDVNEKIADISQKIQKDPSLLESSTIENDIKSAIFLRIALDKQS
VKEMIESIDGVLDKLSLRLIEMIESSDSSTVEIQKIKKELESYNESSSSS
TNFAHAHKKLYTIAIALEENTQALTKDLKKHSSEVGILSKKIEHLEQELA
RAREESKEDFLTKLFNKRALEEFMNIKEAEFERYEKNFTVVFFDLDHFKA
VNDTYGHDAGDAVLVAFSKILKKDARNVDIVGRYGGEEFVAILSETDTDG
GIVFAQKIRNKVKNARFMYKSNRIELSVSAGVSERKIHASLQSTMKAADE
ALYKAKDNGRDRVESK
>Tmden_0551 hypothetical protein
MLGQAKGVRANYAKNKDIYSQNAEYGEESKQQATNAKIAAQGGIAAAVTV
DVKDASMKAAEQAGNVGRKWDNIHDAKFLENQIAGLESAGADMSEFKGKE
GLDYLKQIGSSQAMKAMMKDSIVDANGKSVSFATGKDGHVGMVSVDGQTK
MANGVSVETGGAVAALAEGFNMTEAAIKDGHHVDIQNGKLIGNKASKEAF
MKHIGNNQKNQAMVTSAPGEFLTVLQDLAEEFTPEVVADNFGKVAFAAVM
GTAAKKMVVDPLKKSLPPKNTSSSKDISDNSISSNSKESKDSVNHDNTSE
HRNNIKDYTEDYQKSQESRDKEIQNASNLKKQRNKLFEQGKDTSALDDKI
SDSYERAKGHQENMDKADRNIKAEKYIASKNIDKEAMDRKDKNGGSSKAG
WLSALAMPLVNELADVMGVDKSQNLAFSTIEAGSEIIDGGFTAALDVLKA
TGIGGFKALRGDGDAGQYFSKNMSSAASSVMSGFSNANETMATYAIMQEF
NRQQAAPQHQGFSTLPSGHHTMQAVSADMQQQAAQAQITMANNTQALSSI
APNRSYVGLSMTDADQNPVSFTTDKASRNMMINGYNTGMPAQQFGSMMQN
PEAVSQFANAISQTSFSNVEAYNATNNILMDMNAQTQRANMQQKIHNNAS
DTRNAMQHKESLEANSQKSKEEYEI
>Tmden_0281 multi-sensor signal transduction histidine kinase
MVSNDISILFVEDDKEVRAQISDFLTSNMFKDVYVANNGKDGLLKYNIHK
PDIVLSDLNMPIMDGLEMSRAIKALDENTPILLITSNFEKNVTEAAVDIG
IEGCLFKPLSLNRVEKILTKYIEKIMFQREFKNKQKLLEQYKSIIDISSS
VTKTDINGIITYVNNPFCDMSGYSKDELLGKNHTIISHPDNSKEFYEEIY
STLRDKKIWRGHIKNRRKNGDSYYESSVIAPILDENDEIVECISLKQDIT
ELYAKKELLKKRVKEEIEKNIQLKQEREKERLLEERFSIIGKMAAGITHE
INTPLTYIKGNLELMMHDIKDLDDEIKQKNYLQEDSKVILEGVNRISSIV
ESMREMASQAKGMAQESNVYSSLITALILSYTKASYISVQNSPFKISMDK
NRYSFIAPIQKQRIEQVFIIIINNALDALKLNQPFDARELNISLRDDDEY
VVVSFKDNGGGIDEGIMPHIFNPFQSTKVEGGIGIGLNVAKRIMQDHGGE
ILARNYEKGAIFEVYIPKRSKLQDDS
>Tmden_1758 histidine kinase
MRKHAVLITVLFALTVTLVSVSVVFWKFFQLNKQNYINNIFTKHAIITQI
YQQHQQKVDSQIMLEANLAVYNFVLEKDEKDIEIVLKNAKILKKKDFQNV
NSSLLFSGNGFYTKQIVTDLTATMLEFNRKIYFYLQSPSSSVLILDEELK
PYKYWNVAYSYLVIIFIISVSFVLILRKLRPLIRLRKKIALYGDGDMNVS
FKANGHDEIALVSNELEATREKINLILESRTLFLRNIMHELKTPIAKGTI
ATQMLESQKQKDRFSSIFGRLESLVNEFALIEEVTCMGDKTDFKEYRLVD
IIDGAIDMAMIERSSITVEVDAVHKINANFRLYTTAIKNMIDNGIKYSID
SHVKILIKGHELAFESRGECIAHPLQYYIEPFTKDNPSKNSFGLGLYLVD
SILKAHNQVLAHEYENGINRFIFA
>Tmden_0106 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)
MGFYIKLDLKLKLLIILVIPLLFVIGLSITILYGMLVDKNNLEFTKHHIL
EAEAISKAVHSLQIERGVTTELLANDGIDENTQQLLIAKENSNIAINEAK
RVMLSCQTCIDSTSLKLLDILALRENANLLNIPLSEARCFYTKNIASLLN
LIKTIPSLIEDKDNRNCIQSYSYLSSAKEELGQIRSILVQALLSRDVSDD
IFILFKEHLKVYNLETQNFKTASNKDIINFYNDVFTGEDVDEMFKIINDI
VKNKNKFSLTTDYSQWFQRATKSMNLLRNVEERLFNTINTLVNQKLDSIH
YKLAMLLSFLGLSAIIVTILLLLIARKILFSASSLESKYDNSLLLLEQYK
STIDRGFIVSKNDKNGIISYVNDEFCKISGYTKEELIGKTYDLVIHPHSD
KKFFDQMWYEVRELKKPWINEIKNITKSGATYWIKAILSPIIDKNGNILE
YIAMCSDITQEKEIARYFEDQLKISATNFDYSMHISKEYEKAIDSSAILL
RTDVNGIITYANDKFLEISKYSLQELVGKNHNFFNSQDEALENHQTLWQG
VIKSKTKYGVDFWTKTTIVPIKNLHGEIIEYLEIRFDITEIIRHKEEFEI
AAKTDSLTGCGNRLRLHYDMQENEKLSVAIFNLDNFRQINDFYGHNFGDL
VIQTIASKINMYIQHDKNFKFYRLQGDEFVTLAINAPKDELLEKTKGILK
LIKKKFYIGNEELLISCSAGISFEEKEHLLSTANMALKITKKSSTDFLIY
SSEISLEDQYKNNLNWAKKLSSAIKENNLVTFYQPIINNSIDNRENPTKY
ECLIRIVDNGKIISPFFFLEVAKQTRQYSEITKTVVKQSFELFKDKHAHF
SINLSVLDILEPRTTTYIFEMLKQYGIGERVIFEIVESESIDNFESIVAF
IDKVKSYGCKIAIDDFGTGYSNFEYLIKLRADYLKIDGSLIKNLDKDKNA
LLVVSTIVEFSKKLGMKTVAEFVENREIFDIVRELGVDYSQGYYFSEPVA
QI
>Tmden_1328 diguanylate cyclase (GGDEF domain)
MRLLVLFLSLFSLSLAQPVVNIDSDKSAITDFELSYFIDDTDELKFEDVA
SMKFVQGKNRDSLGVKVKEAWIKIELFNATKEKQRLFLHQDVAYKYISLE
YFETDSSNNLIKKELISPYSDKAHEQLSGADAIFEFTLDSHESKTIYVHQ
KTPAYHFYNFFIFSQKESTKYLIYEKVDSVLISGLLLALALYNFLIFISS
RYKEYLYYSLYLLSTTLWIFYAYGSMAHYFQVYGDIPVKFNFGMMLSPIF
LALFIQTIFKTKEQYINEHKLLNSIIFVSLANFIYGLIDFNSALEIMSSS
LTYALIVFMWISIRICKKGDKLIKIFLIAHTLYLIFSVYALLYYLGIADA
NYISSHGTSIGLIIEAMLLSYLVSYKFIIMEQEKEEEKLKQIELKLLAST
DSMTKLYNRRYFTEISAKVLHLSKREKNNLSILMIDIDRFKVVNDTYGHQ
FGDEVLIALSRLLVEHQRKSDIVCRYGGEEFVILLPNTSLKDATNIAQKI
RILVESLTMEAPTNKEFKFTISIGVAQIDVEHEDDIKFALKRADDALYRA
KNSGRNRVCAEEIK
>Tmden_0532 histidine kinase
MEFYFSLHLSATCFINLLNIISHDLRTPLSTIIGTTNLLLSNSNLDEQGR
KNLLDDINYASIRMKRLITNILDSTRLSSLNIDLKFDWCDFEDIIGVALE
EFADKLQDDLLDIKIEDFRLFWGDNILLKQLLVNLLDNAFKFSVNNTKVS
LHIIDSKNSLKIEVFNQSSYIDERKLKNIFDKFYRLEDSNDISGSGIGLA
ICKSIVTLHGGEIKASAINNGVLIEAKLPILKKANLV
>Tmden_1196 putative diguanylate phosphodiesterase (EAL domain)
MKTYISLIFFLITLFSSASALYYYHIEDEALKRVAHDKEILKAQVLRVAK
ESVTNLTLFESSIKTLQQTNPLSEVKLQLKKLSFSEDILLKKVFLNSTGW
FVSDVTVDNTDGEISVDDSGIYTLQLSKDKQEAVEIKFQAIKDSIIKDFL
IPFATNRVVLSTNETNSTATFEEIQEDDFSLFIKDNFIVDRELLRDKFYT
FIIALSIFMSMMALSGYLFYRFVIIKNFSHSIKGLNNYVENIIKGKMLKE
SALESNSKELKNLYANTIELSKKFINVSNELTVSKDIIYQKERSDELTGL
PNKKSFENDLKYMFISNKDGYIIYLKIDKIGLFTKNHGPEIVDSLIEDFA
QLINNFINKERNRNGAIYRFFGGEFSIILYENSIEKVEKFLLDILELTDT
LRDKYYFFDRAIYYGASPFDHYGTIESIMQSAQEAYEVALKEKTKSYFIV
DLMQQAEFNKKLEGSVKDIIKRNDFVLQYLHDTLTFGENPKLLMQEVSPL
IIDSFTYENIPTGKFISVAEKIGVVADFDKALILKVLEQIEFGGLEHKIC
VVLSIPSIANKLFISWLETMAIENPLIKNIIFTSACYSVASNFEDFKHFN
SILKAHNLENMIKKYDPTDLSLESLIELKPSYLKLDRNFCQDFKKDSTKQ
HVVKQILLFSDTHDIKVIGDSLKSEQDYLAFEMLGVYGNCH
>Tmden_0626 histidine kinase
MGILYYFVSIIETQNLFLLFFILFLLTIFTAIIIAKLSIDPLFEHVRNLQ
NLSTETLHELNLPISTIRTNISMLKKNLSNEKDLKRASRVESACIMLQER
YNELDYMIKLQSANIKHETISLDELLKKRVDFLKQIYPHVEFTLSLEPLQ
ITNDTIGLSKVIDNLLDNAVKYSLNIHKVDIRLHNQTLYIKDYGCGIDEV
ELLKIFDRYYQSNENMRGFGIGLSMVKRFCDANHIALNFKSKLNMGTTVI
LKFKEN
>Tmden_1513 conserved hypothetical protein
MIKSNKISTKIKFIGALLIFLIASVIGTTIYLNHQNIKDALVINIAGKQR
MLTQKISKNIFYIHYQSSHDFSELDDACNEFVDGLNTLKFGNFDKQISPF
HTYEISIQISEVDKLWGQFYKNVQSFKLLKNAQIKDENSINSIVASIYKE
NSVLLKNVDKLVTLYTNHSEEKTNFIKNFQYTSAFILFVLFLYSLAQLKS
IESHVDSFMQYSKMLVGNEDISSLSPIKLEAESEVEIKEVSDTINCFISK
INSAVEYSNEALLQSQKASSKLEELTDEFDTILAEIKGNSSASTHLNNSE
DMVIESTEVLISSTKKLTNLKAELDKLIKSCQELK
>Tmden_1991 two component transcriptional regulator, winged helix family
MKIEKIRDISILLAEDESELRELLHEYLQLFFGRVYAATSGDQAYDIYKQ
KKPDIIITDISMPNLDGLEMISKIRESDKETKIIVMSAHSEQERLLLAIK
LNLESYLIKPIKTEALKTILLDIVKHLREKSRRTYVTENIYWEHETNTLW
GNSKEIKLRKMESMLLKLLFSRPNEIFSTKEIFDYLHETKNDKEFSVHAV
TSLMKRLRAKLPNEVIHNIYGSGYKIIPI
>Tmden_0614 conserved hypothetical protein
MNLFFKYLVLIMLFTCSTLSADVEDAQGVKQLLDKPLVERYVLDELKDLR
VENMRLRNEVERRISRTEVEQTDRAARYMTDTIANVFYLIAAATSILIFA
GWNSLRDIRSKTETIVEERLNTITQKYNTQMQTLQDAMTIQSATTAATTE
P
>Tmden_0735 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains)
MTKKNDTLTNIENRFSLIEYLQSVKNVNLFLIDIDNFNNINNAYGFEVGD
LALVEITRLLNLAKPNSSKLFRVNSDEFAVVSTDIMSSQKLSDIASSIIS
FFDQSEIYISDEIILKVSVSIGISIGSGAEILNHARIAIKELREYKRGSF
KIYDSTSVFIKKQQENIYWVHKIKEAFEEERLITYYQPILNNATDKIEKY
ECLIRIVENGILTPPLRFMEASKLTGTLSLVTKTVIEQSYKKFSNTEYEF
SINITSTDLYLNFLEEYLLKNAKKYNISPSRVALEILEDIDTLDTKEILT
QLNSLRYHGFKISIDDFGSRSSNFSRLIEFSPDYLKIDGSFIKNILSDKK
SLTIVEAIVLLCKKSNIKIIAEFVHNEDVQQKVKELGIEYSQGYCFGEPS
EDL
>Tmden_1154 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains)
MAIHLNKKIFWIVSFLIIISNTILTLYTYQKTNERIQIRALERAESLKDY
FVAMRYVYHKQFINSNIDLNDSTVGFLPAHASTFISNKFSEISKDKITIR
NVTDRPRNPKNMADNFELRAMEYFKNNPKAESKVEKIIENNKEVFHYTVP
LIIEGYCIACHGKKEDVLPFIKSRYDSAYDYKIGDVRGVTSIKIPIENLE
KVAINNFYRTTVFNWSIIFILLLIIYFTIKKMTTQEVKQKIFLQNEVRKK
TAILQEQKNQLEAANKNQKELFSILRTVADCNQILITARDINELIQDTTA
SIHSNSTFKAVKILVIENSELVVKASMGVDVEPIVLPYERVVLKENAPLK
LNAFDDTLSKECRDEMQQNSISETYITPLRKNSHSKEAIGVLSISTTKID
GLSKEEQDMINELSGDIGFAMNSFHQKEAINQLSFYDSLTYLANQKLFEN
HLEQSLMDSEKYLKYGAVLFIDFDNFKDVNDLINKGAGDTVLKEISQRLI
KKAKTASLIARHGGDKFLILLENISKDENQSAMIVKKSVIEIQEITKEPF
IVDENSMYLTCSIGVALFLDNTSANKLLNQAEYAMRTAKRDGKNTVRFYN
ESLQDMTKQRFQMIQYLKESILKNELFLNYQKQFDKDKNVVGVEALVRWN
HPTLGLVSPAEFIPLAEESGIIKEIGAFVLESATSELLLWKSDRIKKEWR
ISVNVSPLQFKESSFVDTINKLITSKNLDPSKLRIELTEGVLIENKEKAI
DKIRDLKNFGISTSIDDFGTGYSNLSYLKNLQIDELKIDQSFVFGLGQNS
SDRAIVNSIIMLGEEFNFEVIAEGVETIEQFEILKELGCNYFQGYLLARP
CKAEEL
>Tmden_1011 response regulator receiver domain protein (CheY-like)
MLVSASIKGKNLTFDYYYNKETQMLFYKNEQITLSKQESQLFHICYLSKG
SFVPMHTIEYYIWGEEYVNDSTKRGLIYRLKKKLNHTIFEYLGGFGCKVD
GL
>Tmden_2003 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains)
MISKKELNFFSPKPLILISIIWLVVGFIFITSKVETLKSEKYQNLTTEAH
DKLKTLINEKKEALLFVTLPLANDILIKEALAKRNIQRLNLLKFSDNLSK
NTSLKGTWFQLISSDGKSFYRSWIDKRDDDLSLIRDDVAEMIRNPHVISS
ISAGIFDITFKSMVPIYKNDNFIGSIEAISNFDSIDLKMRDAGYEIIFLA
DKKYKKLLIEPSKKTFISDYYVANSNYNKEHFEIVKTKGITHFLNEMPFH
VNEEKNKLISTYHLMGVDDKEIAYFIIFQDLDAIDFSSISRVRDSLIFFL
FSFFVFLILLSFYIYFTNERREIQQRNINLQKKVQTAANELEHLSRHDHL
TNLPNKTLLIDRLEHSINVASKNGQKVSILFLDLDRFKEINDTYNHEVGD
KLLQDISRRLKKLIKEEDTIGRFGGDEFIIILNNSNETQTVEVVTNIMSA
MSEPFNVNKVKLHTTFSIGISIFPDDGNSRDILIRNADTAMYEAKSNGKN
RYQFYDKKMTELAFERTTLESNLRKAIQNEEFEVYFQPKIDARVDKVIGL
EALIRWNHPELGLIPPVKFIPFAENIGLIIEIDRWMMREAAAQVLLWKKE
NIVCGKLSINVSAKQLEDDNYVEFLSQKINDIGIDPKDLEIEITEGLIMK
HSLHVTSTLNAIRELGISISVDDFGTGYSSLSYLKRLPIDKLKIDRSFVK
DLPHDKDDIAIVKTIIALANNLSLELIAEGVETKEQRDFLLSEGCHNIQG
YFYSKPLKVNECREFLLNYM
>Tmden_0078 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains)
MLNNISFYNFMHKQILVLIALFVSTATSYVFIGIAYSSYIIEPLWYMFVL
TLSYFGYKLYVEYSDSNLTIQEKEIWLKKLRYFIFSYFSSWTIMFVVYAM
RDNIELHYLAIFTQLGVSVVATTLLVSEKKLATFILASSMLPITIYLLLI
GEFYSYIIAILTIVLAWVLYYGLRNTYGYLQKNQYQANHDYLTNLGNRRY
FVELLKDAIKKQKSNNKYMFLFLIDLDHFKTINDTLGHDIGDKLLSEVAK
RMGLLAKLNRSTISRIGGDEFCLLSDTYEDKVTCLKRAQSFAQELLETIK
HTYIVDEHNLYISSSIGVSIIDNPNITANTLIKEADIAMYEAKLKGRDGV
ILFNNELSVRVERKLEVERFLRFAIKKEEITLNYQPQVDKKGKVVGCEVL
VRWHNEQLGSVGPDEFIPISEQTGFIIELGHYILEESFKTLSEWDKKGLK
LEQFSINISMRQMFCNTFIDDMLLLCAKYLNDSLSSKLIFEITESSAAED
IPKLINTMNRAKACGIRFSMDDFGTGYSSLSYLRQIPIYELKIDKAFINE
LGNPKKDANMVKTILNIAKNLGLSVVAEGVETQMQEKFLIDEKCDILQGY
YFSKPLSKDKFEEFYLKGKISSL
>Tmden_1926 PAS/PAC sensor signal transduction histidine kinase
MNFLNIRYKLLFLSIIPTLLTLLLFFMILSQSLSEKNNFELTKGYILESI
AISKIVHAMQTERGLSSGFLAKNELDKQDTNLLLARDALNKALDNAKYIY
KKKQLKDKTILNLLNEIDVTRKNMDLKTKSIAYIKDYYSQKIELLLSYVA
TIPTFMNDKESRNFVQALVYLSSAKESLGIIRATLNKVFIENKILIDDYS
TIKGSLKNYNHNIDAFKSTITEDFLKEFEEIFKGKNIDNTFAIIDDSLAN
SKNNIDFATNPDYWFEQASQTINLLNSVENALFHEIGNIIDEKLNSIFYK
LALIVILSTIGIIALISITFSFVKNILTSTNKLNEEFSNSKSLLEQYKSS
VDRSFIVSKTDKKGVITYANDEFCKISGYSRDELIGKSHNIIRHPDTEMA
IFKELWHTIRDKKEPWFGEIKNLKKDKSSYWTKAVINPILDSNQNIIEYI
GIRTDITELENAMIAALSAEKAKSTFLATMSHELRTPLNAVIGFSQILMA
KDDMPKEKIRTFVEKINISGKHLLNLVNNILDFSKIESGRMNLNKREILL
ENFINETILLVENEALKKDIEIIKKGFFEISLSADEQLLKQVILNILSNA
IKFSNQNSAINISYKNDEENHIISICDEGVGLSQEQLEKLFKPFSQVQEH
QNTALKGTGLGLVISQKIVELHNGNIEVKTQSGKGSCFYISIPIIKA
>Tmden_1556 response regulator receiver domain protein (CheY-like)
MIDILIVDDSSIIRKIFSDHIEKMGYKVVGVAKDGREAIKLYEELRPDLV
TMDITMPIMNGIDSLKAIKSKFSDAKVIMITSHGEERLVMEAISSGAKGY
VLKPITLENVQQAIYKVFPELATKQ
>Tmden_1242 two component transcriptional regulator, winged helix family
MKMKNRVLKDLKIILVEDEENLARLLKEAIGDNFHSFTVAKDGIEGIEFF
KKIRPDIVITDIMMPNLDGLKMAKELKRINPNIPIIILSAFSEKEKLLSA
IDVGITKYFIKPFDAEELLEYISSITSRIENKILKLSDCYIFNKNTSSLY
KNEKYIALSKNDIKFLYLLLDSKNRTVDDISIKEALWGGDASDERLRTFI
KRFREKTSKMLIKNIKGFGYQLLLNEN
>Tmden_1646 diguanylate cyclase (GGDEF domain)
MNDKNIIRFVTFAPIITIPVIVSLFFYMSIYHTEEIFNNSTKNLKQELIL
KEKNNTISKVKMAVEILKYENSTLEERLKYKISDRVNKAFIIGSNIYAQN
REFKSEKEIKKMIVDVLRTMIWNNGESFIFILDKKGTFILAPQYLKHKEN
KSVIDFQDSSGRYVIKEEINLVNSSGEGYLWDTFTRPNKDQNMQYKQMTF
VKDFEIYDWYLGSSEYLDIVEEEIQQSSVTILRNINKNENDYFFIYDMNG
KIILHSQNPELEGKNFLDEKDKTSIDVAKKLLQSIKIEGSNFASYNWKNP
KSGLIEEKISYFEKIPNTNLMIGSGFYTKEINAIADEKNRELEKINREEL
GAIKIYSLIFIVLSIFIALFISRKLQEKFTLLKKNLEQKSDELILLNEEL
EEKVEARTTELRDAYEKMRQLANTDSLTQINNRFSFLNQFNSLLERYSKE
SKAEFSLIMIDIDFFKKINDSYGHHVGDYVIVEVTKLTKACLRESDIFGR
VGGEEFMVLLLHTSLEAAKETAQRIRKTIDEYKFEFIGHATVSIGVISYD
NKEKSADMLKRVDIALYEAKNGGRNRVCSI
>Tmden_1265 UspA
MKKFTVLVAIDFSKSSYVVLEKALSFTNQMDGELHVVHVVESSFFSKKID
LESTKNSGFLKLSEKFSSIKKENYHCVSGKVKIEVANTANILNADMVIMG
NSGETNFLDALIMGSHTKEIIKHAQTPILIMKKEHELKYENILILTDMSQ
ESAKAIKYTAKLFANASITLVNLFYMPLGSTMSLYGMDPQSLATYQQSIQ
EESQGELESFLDSLSLPQEIDVTASSIKSTLSAKTFNEEVKGIKHDILVI
HATQNVSFFAFDILEQSLTDVFVVK
>Tmden_0645 diguanylate cyclase (GGDEF domain) with PAS/PAC sensor
MKNKYNNSISLKKINFLIIFFVTTLLFLIVFLGYSATKEHFKTQDIERIK
VNILNLGYLVVPVIEKGGMETLLPMLKKSVELHKEYDAIHVSVDDKIVLS
TSQNGSVKESVYVNSADISRVKEDVSFYANFSYFDKEKNIELKLIVDLDA
KYLLNSEKNVQSLIVKYMLYFIFVALLLFLILYFLNVYPLMKLNNNIKNH
KLKKLRFFVKEHSFLYNHFMEKYNEIADLNKNLEEQVAIRTEQLSKTNRL
LKEAQELTRIGSWDYDLEDGSILWSDELFNIFEVDSDEFTPTYETIMNFI
HPEDRQSFQEMFQNAIKQKCDYSLSYRVVLGNNIEKIIYQKGRVEYDMLG
NVKRITGTAQDITQRYKTSKELEFQSKLLNSVTESIFVHDLDGNFIYLNE
ASYITRGYTKSEMLGMKVQELDYSDEKNSAEIYEENLANLQEQLSKKEKA
VLEVSHRTKDGKILPIEITCKLIKEKDKSYIISIARDISELKAMNKTLEK
MANTDNLTGIYNRRKFEEIIKIEMERSARYNSNLSLIMIDIDHFKRINDT
YGHDEGDNVIRKTVEIVSKNIRHLDVFVRWGGEEFIVLCPQTESKNASIL
AEKLRVAIESVNYETLGKITCSFGVTSYIKDEDKSSFIKRLDTALYSAKD
EGRNRVVAL
>Tmden_2087 putative PAS/PAC sensor protein
MQNSDLIRLNDICFWNKETDSLHVDDKDIKLSISQKRALKLLIENLGKPV
LNADIFYEVHDSLDKEFNEKSVRNLISGLRKLVLELNIVNIYGGYYMLKN
ENISKDIKFKEQLFDIVEQSVNPIVVTDPNEQDNPIIYVNNSFCELFRYK
YEEVIGKNCRFLHSSDKEQKSLENIREAISTQKSVEVKIRDYTKDGNKLY
EDITISPVFDKEKEKLVYFLGIYKDLTSIEQFLEKVKEVL
>Tmden_0086 hypothetical protein
MKFSRGLYALLLTLFFNSSLVAQYLYKDELIFNPAFNVEIEKLGSELYEK
TGISLRLVMLKKLPDSKNIVEYEEQLLAEFDKPTILLTFSQMDTKVDILA
NETSLYNYFDKKQILSPVASVVQAFTIALFYSDSFAMFKEIISDYGGTII
PLLAQKSKDNELLGKYSGSMFNGYADIADQIASSKGVVLENSVGSANQQS
IFVVKVLFYGFVLYGIYMYIKRKLYLRKQKNETK
>Tmden_2015 diguanylate cyclase (GGDEF domain)
MMNNKEKKSLILRTAVTVLVALVVLSIIRTLIINQDLLRSDFSYMLFIQE
AVFSIISALIITLLLFLSLREDLKKINIKAHNYAFTDGLTGLYNRHYLND
FLEKFNILQKENSMFAVIFIDIDKFKEINDTIGHLAGDCILKSLALRLKY
LTQDADILCRYGGEEFVIICSDISEENIVQKAQKIREEIQNSIFECEHVN
ITISIGLSFGKKGCDINSVLNEADEALYMAKKSGRNCVSVFDNKKGLSI
>Tmden_0439 carbon storage regulator, CsrA
MLVLSRKIDEAIVIGENITIKVISVEKGVVKLGIDAPKNLSIVRSELLED
VKDSNIAASKEINLLDITSLSAILKK
>Tmden_1459 histidine kinase
MRIKSRFQNISIKQADVFTILVVFFFTLVFVGLLVEELYKEYEIALEQSH
VVKNPLISDSTILKQNQKKLKALLIKTVLAIVTLSFIIFAIFLGLNTLFN
KLLQRDTQTFLDAFKTAIDKEKTIDSKSIFFQDFKMMVGYANEMVSKINE
QKKNLKELNLGLEERVKKKTAALLEINKNLEEEKTFSQDLLKSQKEFLRY
TVHETNTPLSVILTSIELYLMKNPKDRQLSKIEAATKNIFSIYDDLSYLV
KKDHVEYTKSVINLNNFLSSRIDFFREVAEFSLITFNYNSPKYEKHVHFN
ETKLQRIIDNTLTNAIKYTLPNESVEVSLKKIGSYIEFIVSSKSKTIQDT
DKVFEAYYREEKGRDGFGLGLRLVKSICDAEGVNINVSSDEASTTFRYKF
KAMGD
>Tmden_1484 diguanylate cyclase (GGDEF domain)
MTTKSKLLLVVTIMLLGLTAATIVNIALNFREYSIKSATDKAEMAANIVK
DGITAHMVNGIMDKREYFLNQISSTGSVEFLRLIRSQGVIKQYGDGLDKE
NTKDTIDEEVLKTGEPVEKITETATSTKLRVTIPYKATSDNTVASCLNCH
NVNKGDVLGVISMEFDITETRNSGMMTVLKILGINLLFIFVVLLLMNYFV
TPYMKLFSNLQEGIKKAYSGDFSHEFVSNVGGDAKNVVKQMNSLFSKMQE
TFGDIKFNLATFIPQGSVSISDPLHEAKTIISELSDIYKFKKTIELDASK
SDVYIRIIDILKLKYHVGHFAFYEVNNVTSERKLIYSTEEETICFEKTNK
NAMECRAHRTNSVTISTEFPNLCRACVSQNLDYVCIPFNINHDISLTVSM
TSGNRDEVDLMKKNISSIRHYLEAAKPVIESQILMEKLRDTSLRDGMTGL
YNRRFLEEIIDKIMSQANRNKETYAVLMLDVDFFKMVNDTYGHDVGDKVI
VALSKILKNSIRESDLAIRYGGEEFLILLSNATDEGIMQVANKIHSNFAA
LSFDVGTSETLKKTISIGISKFPTDGDTIWKCIKYADTALYEAKNTGRNK
IVEFKKDMFKSGDEF
>Tmden_1488 response regulator receiver domain protein (CheY-like)
MDKDLKILIIENEVYLAQSIATKLSELGHVCEMCTSTRDAIKSNNYDVVL
LSTNINGQDFNPVIETFKKSIIILMVSYISNDTVSKPLSAGAKDYILKPF
MIEELIRKINHYQDYEKLKKRNIAYDRYLTHNFSSISTEHNFENIELPLF
ISSTYQKHADSFAFEYAKKKNLPLHFITLSDSKAMSEIESITENSLIYII
DLQIFKKAERKALYALLENKKAILSSSDKIEDDEFSIIEMKSENNIFDQG
EILPIEEYVKFIVLNYQHKFPDTELSKKLGISRKSLWEKRKKYDIVKKK
>Tmden_0974 CheA signal transduction histidine kinases
MNKHDRVMQIFLNECKEILEEIAPKLLNLEDTPNDKNLINDIFRGIHTLK
GNANSFGFVKLGEFVHHFEDLLSIYRKDESVLDSSEVDLFIRSFDIVGSV
FEYEEDGVDGYPTNYYEILEEIKKALNIKENSKESFEEIVSASSFAHVAQ
ESVIVKKMVEHTQYNLKDIGDKKIYEIKLELDSDIYLRGYNHQIFFRLLE
SLGTLLYSNYIIDENIPTLEEFNTEHSYVKSLYIYLLSDSDEMDILDVFE
FIAQEHEVSLSVVDLKELETLQEKESKEEESQSQETLYVQNGSKEHKSVA
KSSIRVESAKLDELFDSIGELVIAQSYISQNEKIRSINDNELNQYLEMLS
KSTRIIQSKVMSLRMIPIRDTFLKMKRVVRDVSVKTSKEIELILSGEDTE
IDKTMVDKLSEPLIHLLRNSVDHGIEESAHDRVALGKEECGNIYLSAAHK
GSSFVIEIRDDGRGIDTQKILQKAIEKGFAKEGASYTQDEIINFLFCAGF
STANSITDISGRGVGLDAVRQSIEELRGKVTVESELGVGTIFRIILPLTL
AIIDGLTIRVDNEMLIVPTLSVVESFSPIIKDIHYVKGEGEFINYRGEIL
PIVRLNRLLGLNKSKTEFENSTFICIDHERGRYIIQVDELLGRQQVVIKS
LGVLSNNVKEISGAAILGTGQIALILNTEGVRDHLDFEYSA
>Tmden_0416 histidine kinase
MTSYYVYSSFLGFNAAQQLQERLDQNKHLNEALSNIARERGMSAMYLGNK
TRNIHKSLIEQRKIVDEKVEDYLKYARNNKRLHTHTSKSNKEECLACSNV
DSVISAIVKIKSVRPLVDAHAIEFKEMFIDAYGKAQIAFIKQLEQITENQ
IDKEVNQLYSLYIAMVNAKEASGIERGYMAYIISRSSELQRDDLNEWISL
IGKADSINYGGIQNKNLISSLDALFKNEDSLELFGDINSERAAIISISHS
GEYDITSGVWFTMLSEKINIIAQAEDLLLNAMNTRAQKVQEESLQVLIIT
FSVWLIAIILAVLGFVLSNQIAKNIRNLESVLEKVAGDYDSKERKINLHT
AEGTDLAYELLEDIIEQTKMDKISAQEASEAKSMFLANMSHEIRTPLNGI
VGFTELLKDSGLQQEQSEFVDIIEKSSENLLEIINNILDLSKIESNKLEI
ENILFNPIVEFESAVEVYAVRASEKHINLGCFIDPSLEFWLKGDPTKLKE
IIINLLSNAVKFTNNAGFINVNIRKIDSDKSTKTRVRFEIQDSGIGVTSE
QKSKIFEAFSQADTSITRKYGGTGLGLTISSNFVELMGGKLDLESKLAEG
TTFFFTLDFEKAETLHETSKNSFNALSALILSDSEKIKKQDKYLREYLEY
YGVGFKTFNAIEKLELLLKDSDYNLLFVDYDYTSEETLRELSKLPQELVV
LTKSNLMKRVDSLGLNIFKILYEPIHASKIRQILENYTLLNAKIEVAKKS
SCKNFDLSKSKFIADVLVAEDNTINQKLIQRTLEDLGLNVTIANNGLDAF
QKRKDGKFDLIFMDIQMPFLDGVEATAEILEWEADYKQPHVPIVALTANA
LKGDREKFILAGLDEYTTKPLVRAEIITILNMFLADFIVEVNETKS
>Tmden_0914 histidine kinase
MSAISSEELNLLIEQTYKVEKEFSELRASYMHLQDTVEEVVEFLPNAIWI
LDKNGDIFLQNSQAKSLGKLFLLLESKKNDYEVTFNTKSYLVKSSSYKEK
IMLSATDITEQKRKENLAIMGQMAAHLSHEIRNPIGSISLLSSTLKKRVM
PENIAIVEEIQKSVSRIERIIKATLMFSKGVHANKASFMWGELQDALNMS
VGYYGYTKEITFIFPEKNFEINADKDLLEMLFSNFLTNAIDAIELDDNES
GEVEMVYDRDEKFHKFRIYDSGIMIENTKELFEAFKSTKVKGNGLGLVLS
RQIASAHGGSVEFLLGDRKGFEIKLAI
>Tmden_1529 CheW protein
MSDKLKQIIKKQNQKDTNQEHVDNVVQLVGFVIGDEEYAVPILSIQEIIK
PFPWTRVPQVPKYVVGVFNMRGAVIPLIDLRLKFGLSPKKHNEETRFIVM
RDGDDVAGFVIDRLTMAIRIKKSNIGPAPDTASGDNTVIDGVGKQEDRII
TILKVKKLLQRDF
>Tmden_0512 cyclic nucleotide-binding domain (cNMP-BD) protein
MKTNPLEIEFFGKIDKNFEKEFYSCAKTIKYRKGDSPFSVDNLLSYFYIV
LDGRIKTYQLNFENAKEQILFIYKRGDMFDVVSLLDGKAHEVIYEVMEDC
RVLQFPVQKIREWLESDLAFKNMFYTYLASSIRYTENLAVELSLYEVKDR
LMNLLLENLNPNARFRYKVLHNLSNSEISNMLGTVRHVVERAIKQLKDEK
IIKSGRKNITVINVHKLLEKSTKMLHK
>Tmden_0259 histidine kinase
MRDKSYALTYAYIYTILVAIILLTPLFIYTSYIKKIQDIKNEYELKNRAH
LIVKLMQEHNSEKDYFEYPRFKTFKSGLYDSRLQEIFSLIQEPIKHFREG
YHIDGSRAYYVMVLPEERYFGAKYIVVENQLSYYEVYEKALLILLSIVTC
IFLLSILFLDRFAKPFKEVNKKLDEFIKDSIHEINTPLAIINVNVDLYGR
KYGKNKYMQRIKASTKVLSNIYNDMEYLTKNNKLEIKREKIDIKKFLDER
IEYFSEIALMKNISILSDMKNEVFINMDVKQLQRIVDNNISNAIKYSYEQ
NIIEVNTDINEEGEYLLSFRDYGIGIDNVERIFERYYRESRQVGGFGIGL
NIVGAIIKKENIDVSVESELKKGTTFTYKFPKNLISIKN
>Tmden_1757 Lytic transglycosylase, catalytic
MNKYMKRGSVALFAISFFAFGWMTHALYNDAYKMIKESTLKKIKKSGALN
VVLLNAPSTYYIGSDGPKGFEYDLLESYANHLGVKLNITTANTIKEALEL
SKNPDIHITSASLTKTPEREKEFNFGPSYFEAQEQVVCNKSLLLDGRFPS
DADSLSGLRVVVGDSTSYSETIESLKKEGFDINATYTAEYSTEELISQVD
THEIDCTIIDSNIYALNQRYFKNIVLAFDISNRRQQAWILTPDSKMLKND
MYSWLNTVNQSGEMARLKDHYYSYVLFFDYYDTVMFYKRIKTRLPKYESY
FKEAAVKYEIPYSALAALSYQESHWNPNAVSYTGVRGLMMLTQDTASMLG
VKNRIDPQESIFGGAKHLDQMIKSVHADVTGEDRLKFALAAYNVGLGHVA
DAQKLAQQLGLNQNSWADLKKVLPMLSQKKYYRTLKHGYARGNEAVKYVD
AIYDYRDILQKNDVEVSLTTK
>Tmden_1780 diguanylate cyclase (GGDEF domain)
MEKILVVEDNKTLAKLIAKKINLELGFEVEVAYNFLEAKLFLKRYSYFLT
LIDLNLPDSPNGEIVDYVLESGNRVIVLSGNIDKTFRANILKKNIIDYVN
KGGVNDINFIINTIARLKKNQNHKILLVDDSMVFRKQMTHMLENMFFKVI
TVAHGEEALGILDNVPDISLVLTDYHMPVMDGLELTTEIRKKYTKNDLTI
ITISGDNDEDTTAMFLKIGANDYIKKPFSKEEFSCRINNSIEALENIHAI
TNNANRDFLTGLYNRRYFFNNMYPYFEKALTNGNHFAIAMIDIDFFKKIN
DTYGHEMGDKTINKLADILRANTSQDDIVARFGGEEFCIVLKNKTPQQAL
SHFENLREKVENSFLSLGDEEKITFTISIGVLLSPEDTLDESINQADMLL
YNAKQNGRNRIEHN
>Tmden_1511 diguanylate cyclase (GGDEF domain)
MNFIDTLKLRSKLFSIFIILSISLLLIGIMGAININSMKKKFDALYFGSF
VPVNELNIILQTYHDNLGTAYKAKEMKIPLDEIRSEIKLSVERIENEWKS
YKSHFKRDEEIAYVEYVSGEIKNTNDFFLNIYTALDSADDIKNLPFDKIE
KRVTDVHKVIKKLINYEIDLAKYERKNFLLIYDSSLYKIGTFLLIIIFGV
MVISYYVLKSIQSDQNALEIASKKLKIANKRLESASYTDSLTSLHNRRYF
NMVYEREIKRAKRNYTYITFMMLDIDYFKQYNDTYGHVKGDVALKSVASV
FKELLKRPGDFVFRLGGEEFGILLTDTSEVNTITTAQNICNAVKELKIEH
EASKIDTFLTISIGVACCVADSALDEEVLINKADEMLYSAKEGGRNRYSV
TTHVSVATPLKLEEIA
>Tmden_0027 hypothetical protein
MAGVHFGFNNFKQLLDLTIGLVQRIDENRAESFTILYCDFSALDHSIVKS
SLEHILRNSDAIVNDKADYFFVLPYTDKYGAEIVKKMFIEFFAADLKTYM
VSYPIDGENSEDLVFRIRDYATLYHKNDLNCLDSFNRY
>Tmden_1603 putative signal transduction protein
MITKENINSFIEKIPPSPKVLNEALSLLKMGELVKAAKVAESDLTLKSYL
KSIVNKPIYGFRNEVSDIGQIFGILGVSLSQQSVYNYMVTLLSPNKWSLF
KLNRSLFYELQATLSKRWEAILIHLNIHDDNIYAAISLLPASIIVTEALF
AQKKEDVELLRSTKALDYNTILMRLCGVDLFDICEEIAKKWEMDDSVSAI
VHAASGIKTSENQEINTLGKWMHLLLFYKLSQPEFINAGLNDFVDFKVEY
VSDIYDDFALLMEIE
>Tmden_0248 histidine kinase
MQFIFRLLFITLATLSSLYSEQLQKVSLQLQWFDQFQFAGYYVAKEKGFY
EDAGLDVSLLKFENSILPIKSILSGSATYGVGRSNLIIEKSNGKSVVLLA
SILQSSASVFVTTKDSNISTVKDFVGKRIMLSDDVVSDLGLRAMINKKNV
PTGNIVVQKNSFDINDLINHKTDLMAAYLSNEPFLLEQKGVKYTIFDPKD
YGLDVYSDILFTSQEEMNNNPQRVEAFTQASLKGWRYAFENIEETVALIL
EKYNSQNKSKEALLYEAAVLKKLAYANGAELGQLDMTKIEKIYDYYSSMG
LIEKKIDFKSFVYQVKKPQISFSEQEREFILKHPEILLSDVQWEPFSSIS
GGNNSGVFKEYYDEIQKVSGLKFSFVQIGNAENFQLVLDALKEKKIDMID
GTGKTDARGEYALFAGPFMQVSLGIASLRDNPYTTLNSLESKKIAMASGG
TAMEFIYQHFKNAKIYETESVDKALSLLSHRKIDAVIDNLAVVDYGILRY
NNSNLLTTQIDDYDFKIYALIRSDYPLLQSIMQKSIEYIRSQEEIKINNT
IINDALYRVPKQVSLSIAQKQYLSEKKEITMCVDPEWEPFESIDEKGVHQ
GIAADLIRLVSERTGVAIKLIKTATWEESLELSKTNKCDILSFLNQTPQR
EQWLIFSDTLLSDPNVIITREDHPYVVNLSEVHNETVALPQGTMLEERLR
KDFPSLKIISAKTEEESMSMVSQKKADMTIRSLIVSANAIRKEGLFNLKI
AGQPNNYENIFSIGVLKSEPILISILNKGIHSITDEEKEQIVNKHTAIVL
QKESDEKVLKAAFYGTIFLLMVLALISLWNTLLRKKVKQEVTKNIEIKEQ
LFQKSKQAEIGNLIAGISHQWREPLSKLSSINLITIAKLKNGIPIDNETM
LKQSDEIEKTIDFMSVTMQNFLMFYKKSTTKINFSALKSIEASLSIIETK
LIDNSVTMEINGDEGILLYGIENEWMQVWLNLINNSIAIFIERKIATSKI
TINVTNEKITFCDNGGGMNMEQKHHGLGINMCHDIVSKYEKTFHLQNFEN
GICATILLMNIKTKS
>Tmden_0380 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains)
MYSLNSKFLKIIPILFLIIGTGKIIYIYFETKEKEADFAKKEAEVLNSYV
IENRNYYQNLFLNGTIDINQKTLSALPAYSSYHISKAFSQNNPLKITLST
VSDRARNSKNSADRDELEAINFFKANSNEDYYFNSKNPNFYQYATVLKIT
PVCLKCHGAKNDAPSYIQQSYENSYDYNLGEVRGIVSIKIPKKELSNYFF
KGFFKSALYDLILFLLLFIAIIYLIRFSKKVNETLEKKIEQKTLEFKSSL
FQDRLTKLPNRLKLIEDIELSMDKKHRHLALVNIDAFKDINDLYGYAIGD
EILIQVSQRIRNFCTDLGSIYKLPNDEFAIFVTDKFDEDNFHKTIKTLLE
TINETKFSIDEQSIFISFSCGISSNKDPLLIKANTALQAAKSTAKSVVIY
KDSLNAKEQITKNMDALLILKEAIAKNQITPYFQPIYNTRSKKIEKYEAL
ARIVREDGSVIAPFAFLDIAIKSKLYPEITKAMILKSFEFFKDKEYEFSI
NLSILDIQNQEVLKFILSKLREFPEPQRVVFEILESHKIENYQEMKSFIK
EVKKYGSKIAIDDFGSGYSNFSQVFELNVDCLKIDASLVKYITTDESSRV
IIKTIVNFASNLGLKTIAEFVEDRESLEILEKMGIDFIQGYYIGKPSNKL
CENFSV
>Tmden_1531 response regulator receiver (CheY-like) modulated CheW protein
MNIDNSLKVGSNEMELVDFRIFKQEEDRVYEGIYGINVSKVREIIKLPKL
TELPGTPEFIEGIFDLRSIVIPVVNLAKWMKIKQPQAMEKNSRVIITEFN
NVLIGFIVHEAKRIRRISWSDIEPASFMSNSASIEGSKITGVTKIEGDNV
LLILDLESVVQDLGLYEPDTQFNNTEIESFSGLALVLDDSSTARKIVKEA
LVNMGFDVLEAIDGEEGLEKLDELYELYGDKISKNLKIIVSDVEMPRMDG
FHFAANVKEDARFSTIPIVFNSSISDHFSEDRGVEAGGEAYLVKFKASSF
YNEVARIVRAHMK
>Tmden_0020 diguanylate cyclase (GGDEF domain)
MNSLKSISINISIPLFISLALGSLVFYEQKIPKVLFSIVPYLFYAITVAI
LWVSWHFNRNRFIFIILPLLLIYVGFIYLGGKRATDLFLYVSMLYPLHLL
LFLSLKERGLFSIWGVLKIAFFVVEIAVVLYFVFYPNNDIIALLKTKIFT
TSFYPIEDITVVIAAFVITVMAMLLIFNRSVLYNSSFLIILLTFYIGFYF
IRTPHVKELLLLSIGIIIFILLIRESYRLAFYDELTALPGRRALIEDMAK
LGMKYSFAMIDIDHFKKFNDTYGHDTGDEVLKMVASKLAEVGGGGKAYRY
GGEEFVVLFPSRELDESYKSTDILREIISKSPFVVRNKQSSKTIYINISS
GVVQKTSQDKDPFAVMKRADNALYKAKKAGRNQVVKA
>Tmden_0968 response regulator receiver domain protein (CheY-like)
MSIVKELKDFAKNLSVIIVEDDKALNEELVGVTELFFKRVFFAYNGVEAL
SIYKNNNIDIVITDITMPKMDGVVLSRNLKQINPNQDIVVISAHRDIEYL
VKLVDIGIKQLIYKPFDHQELLYRLLRVCEDKVLSNKMDEYKEDCSSLLN
TTTVANNSIQNKKAIYKNQNRTILHLNSEMEQDIEYLLELRDDLENLVNE
LHYGVEVSVINGISSVLSKIYTLLSQIGATTKISVVIFELANFLESINFE
LLSDEQKSKLEMMEFIYDDIAKFVDLIFVKREVQDTSYLEDSLRSSLSQL
KQSVFNDFLVEEEFELF
>Tmden_1199 putative signal transduction protein
MNNDILAQIDSLPPLPQTVIHIEEFKNKEDKNPADLAKILGKDPLILSTL
LKVSNSAMFGFKKKIETPQMAVSLLGVNFTISLALGSAIKNLIETSLEPY
GADSNKFLETASQAIIMASKWASEIDIELRDRLLLPTFLLETGKFIIARI
IKEKGLSDEFYADVKDAVDIASVEKRYIGASTSMITAAIFEKWGLSEALV
NDIRYVDEPSHPENKSLLVSQIVHTVNRVCNIVHPFKEESIKSAIEYATS
LSLKPAELEQIIADIKEKQ
>Tmden_0983 methyl-accepting chemotaxis sensory transducer
MLSSISIKLKMALIVIIPVFVILISLGMDSYRSYNEVAILSQIQEMVSFT
QKSSSLVHNLQKERGASAGFISSKGEVFSSELNSIRRDTDEKYDELKKFY
SSMNKETHSSALQDKMSKAMQSLLELQSIRESVSSLGVVVGIPVAYYTKV
NNSFISSIEEIAKISHNAQMNNMISSFVNFLASKERAGLERAVLSSTFSR
DNFADGFYEKFITLLSEQNTYMNKFLFSAPQDMIEFYTQTMSATEIQEVE
KMRKVALSKPNGGFDIDATYWFKTITSKINLLKSVEDKFSAQLESNVVAL
KRSASNYLMLSLLVNSLIVLFIVGFSFYVSNNLVSRIKRFKDEIDEIITT
KDFSKHLTQNGNDEISFIQESVNHLADVVNQSMQEAKLSLEDSQKHYMEN
EKQLEANRLTLGLTELLNRGAIDGASEVQSGILETMEALNQINKKNAQTE
EVVANVQESTHKMSSSLSNISQKMNSSKENADQLNSSVIEISNVIALIKD
ISDQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQRATNEVELN
INLLKQNSSSMQEFSEQMNVEVSTSVEVLELFMSSLNSLVTSAQQIQHSN
KEVSNAMFINLAKLDHIVFKFTGYDAVFKDDRNFKFSEHTACRFGKWYIG
DAKEIFGKTTSYAKIDPIHKVVHDRVRSVPAYIEDGAVKNSTKIILAFSE
AENASKDLFKILNTMAHEIK
>Tmden_0637 response regulator receiver domain protein (CheY-like)
MKIAIVEDDINMRKSLEIAMSDYKEFEIITFKNAKDALKGINESFHLVIT
DINMPGMDGIEFVKELDGKFEVIIMTGNATLQRAIESIHLGVKDFLLKPF
DVDTLIAAIKREDKIQKVKKIVHAEQKNVNNSGFYGTSKALESALHIASK
AAKTDATILLLGQSGVGKEVFASFIHEHSPRSKKPFIAINMAAIPDNLIE
SELFGFEKGAFTDASEAKAGQFELANGGTLFLDEIAEMPYGVQAKLLRAL
QEKEVRRLGSSKSIKIDIRVIAATNADLEQKIHNGTFREDLYYRLNTIPI
IIAPLAERKEEILAIAQKILEQNCVKYGFELKSFSDESKKQLLAYNWPGN
IRELISVVERAVILSDANEIAPEGLFLSSRRFTK
>Tmden_0837 two component transcriptional regulator, winged helix family
MNIESITAIIKFKIDIKSESYLSSKKLLANTKQLSILLVEDHDDLRENTK
EILKKFFDTVDGSKNGEDALKKYKEFHKNELKYYDIVLSDIQMPRLNGVD
LVENIYAINSDQIIIILSAFDNSKYLLPLINLGIEQFIKKPIDYQDLMKV
LLKTTKKIILKNEQKNSFQTPSLIKLAGLCTFDKETNILLVDNDMVTLTK
YEIIFLQILTDNIGKIYSNDDITKQYDLLNETLDIINIRKLVSKLRKKIS
FNCIESVYGIGYRIVPHFN
>Tmden_0970 response regulator receiver domain protein (CheY-like)
MLKKVVFVDDSKAVLASVELAVEELVANGSISFDTYSNPAEFLEKVTSGS
VDYDLLFTDINMPQMSGLELSKKLKDIASIRQKPILALTTENSTEIKQTG
KDIGIAGWVVKPFSNDKIVLAIKKVLGI
>Tmden_1034 response regulator receiver domain protein (CheY-like)
MKILIVDDSKIARMGVIKSLKVVQPDAELIQATNGLEAVEFYEKENPDVV
FLDLTMPVMDGYEALKRIREIDKEAQVIVVSADIQSEAKLRVLVAGAKNM
YPKPINVDIMVQIFEQDLLL
>Tmden_1938 quorum-sensing autoinducer 2 (AI-2), LuxS
MPLLDSFKVDHTIMPAPAVRRAKGMKTPSGDDITVFDLRFVAPNKEILSS
EGIHTLEHLFAGFMRDHLNSKDVEIIDISPMGCRTGFYMSLIGSPDEQRV
ADAWSASMQDILGVKEQKDIPELNVYQCGTYKMHSLEDAKEIASKVLERR
IGVMDNDALALDESKIG
>Tmden_0417 putative PAS/PAC sensor protein
MNKIVPNDKEYIFQGKVAICQTDLEGNITFVNRKFCEISGYSVDELNKKN
INMLKHPDTNPSIYEKMCSTLKGALVYNDMLKIIRKDGSYYWVDIEVTNI
VDKQERISGYISISKPSARKNIQYEMN
>Tmden_1171 transcriptional regulators, TraR/DksA family
MQESELKYFKEILESRKEQIIKNIRGVNEELSQLSSLELKDEGDHASVDN
SSMIESAIVHQQEQELREINVTLGKIATGDYGICEMCEDPIGFQRLKVKP
HAIYCIDCREIVEKSR
>Tmden_0885 histidine kinase
MQNIALSISSKIISSYMHSEELHVEAVDGYEIALYSIDKEPIAGEFSGVK
FVQGFYEDGEFDYFVDLTPQLHHGVKYLVLKSKNANEQILKLIKNTLFIA
IFSVILVVVVGYFLTKMFLKPIQNERIKFDKFIKDSTHELNTPITAILMS
IDRLKKENIDEKILSRVQISAKRVQKIYSDLTYLLMDNKSQETKKLNIKS
MIESELTLYEDLASKKSLTIEKELEDLFFSIDEVSAQRLFSNLLSNAIKY
NKHGGVIEIKLKNGELIISNSGIGIKKELQDKIFDRFYRANDYEGGFGIG
LDIVKRVCSRYSIDIKISSKESSKTTIKLKF
>Tmden_0463 histidine kinase
MFKINGFFTSGWFFDESECELKNRYQMINIGILLSASGLVYGIIGNYIRG
TDGFIPLELALLCTNIMMFFALRMYRNFFEFFAITMTLQYTFLFLFLIYV
GEPSDLKHLWIFTYPIILLYFQKTIHALYWLGFMLVMLIIAPLQGFVSTN
YSMYQVTYLSFVLAVVSIIIYFYKKKIDEAKNTILEQQNMLKNFNSELER
QVKDKTTELIKLNESLGIKVEQKLEELRKKDQILELQSKQAVMGEMISMI
AHQWRQPLSNITLQIANLQLKHMLDKERRCRDVDDALTNISNTIIYLSDT
IDDFQTYFCPNKKMDTIEIHELFQRAVNFSQSRVQDNDIKISINKEIKIS
ITVYINELIQVILNILNNAIDAHNEVKPKNPSIIMDATDDDENISLLITD
NAGGIDDEHMSHLFEPYYSTKGKNGTGLGLYMSKMIVEKQFNGEIDVQTS
SVGSTFIIKIPKNIK
>Tmden_0909 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains)
MPKTLKNFIFSINIVLLSSLFIVVLLFTSYLHTKLAQENAIKHSNIVSNQ
IFSSMYQVMKKGWSREDLNEFMYSIEENFDDSYSVNIYRGDKIKELFGEV
EEKQKDDLAASVMKSGKKFTSSDMGKLRNILPLIAKTECLSCHVNAKEGD
TLGVIDVEQDFVEIIKETFLNYVYFFLIVLPIFILGAYISSRYTTSKITD
SLKLFNAKVEGINSLNDFKEFDPTEIDLRFDEVNAIIINVNELAKKLRTI
AVDKDLLEFEVQLLDKFIITSEVVRDWRDFINELLIDINKVMQTYTLMTI
FRIGDDQFEVDIFWHGIPDLDVKEKFEEYVRVSVESSNHFLGYTDYTIRH
NISEYKMHIDIKDYEKFAHRTKSLFLDTPKIGGIVGLSVQSEMASDPIKH
IVIDSILTTMANLVGSVKAINKYTNDLEYYAAHDPLTSLFNQRVFIDFLE
YEIKRAESHNYEFALMVIDCDNFKPINDKYGHAFGDQFLQEFSRVLFESK
RNEDILSRYGGDEFTLILPECGLECALAVAHKIARAIEDFKLLTADGNYT
GVTVSIGISIYPEHAKTQKELFLIADGMMYKAKEDGKNSIRVPSGDDIIS
VVKEQKAKSVLLMDAVANNRIVPYFQPIQTTASGKNEIHELLMRIEVDGR
VVSAYEFIEVAESMSIINRMDLMVIENAFIKIKQENYSGILFINLSPKSL
VVGNYADAITKLIKEYDISKDNIVFEITERETVKNFSLLEKFVINLKMAG
YKFAIDDFGSGFSSFHYIKKFPIDYLKIDGEFIININKDKKDRAFVNSIL
TLAKELNVKTVAEYVEDEEIVKTLREMGVDYLQGFHIGRPQKSFTIRD
>Tmden_0808 CopG-like DNA-binding
MEKKLTMRVPKELEDTLNKICATNNTSKSEYVRNIIVEHLNESKKEEGKI
IKRLEKMEQNMNENFDKSNERIIKILTRILLYALANFHLLKLKIRNDLSE
NMTQETKDKTISVYVSEAKKLTNNHEVDSLQPKNNKTFFDNVIEK
>Tmden_1243 PAS/PAC sensor signal transduction histidine kinase
MLKQYKEAIENSNIISKTDVDGIITFVNSEFCKISGYTKEELIGKNHNIV
RHPDVHPFKFELLWQTISQKRVYKDTVKNLAKDGSTFYVNTTIIPILDEN
KNIAEYVAIRYDVTKEILLREELLKKEAEYEELNRSLEKRVAEQTKELKE
LNQTLEERVREEIEKNEEKQRVMFWQSRHASLGQMLANIAHQWRQPLTEL
SLAMFNIKKAMQNENGAEASKFYNESKHIIKNMSQTIDDFTNFFSPDKEL
HYFNIKDSITEAVLLLENVLSEQMISLKKELIDIKILGITNELTQVIVNL
INNSKDAFIHNGILLREISIRIKKKSDFALIEFEDNAGGIAKENIEKIFE
PYFTTKHKSRGTGLGLFMSRMICEQGLGASLDVVSKKHTTIFSIKIPLDE
DEK
>Tmden_1927 histidine kinase
MGNSLELIIKNFNITEQVLSDRKNIGLYIESLSSLIVDKFYDYLLSNADF
AKLIDPKDIPMLKRVRAQFIVSLFNDDFDDLLFNKIKQVYKDSPVRPNTY
LIASSFEIIMQSIIDIASVNHQLQRGLKTIYKFLHIAEFIMQKEFLDDSA
QKTTTSKNSLINALESLYEMLSIHKSKHELLLECYEKNIIDTSNIIELPS
NDVLLCRFHETTSAIKNLVLDMDYFGVDISIIDELHRKYHQNVSDLYSAI
DKNLPKNEQQAYLNNTAQTSQELFEQINKPFEKVSSLTFLVVNGGMRFIQ
QYGYILNETKFIPFDKAQEMCDFIKNILKESLQESLLWAIDSYSVTTKED
ERSSDISERIVFNNATIFITLNIKKIPYSSFIFDILHIFLEILKITLINR
EKEHKLTIFADKAESANRSKDMFLANMSHELRTPLNAIIGFSQILQTREE
IPQNMRSYIEKISIAGNNLLNLVNTILDFAKLEAGKISYHPRMTLLSDIA
KEISIIISPLAEAKNITLTMPADISLALFIDAQLMKQSLINILSNAIKFT
PNDGEVIFSITFDKQRNQYVLSICDNGVGMDKESISQLFTPFTQIDNHLQ
TASKGTGLGLVITKKIVEDLHGGKIWVESSVGEGSCFYIAVPIQTELTKI
EIFASKNSDNEKLLIVEDSEEYVKILVEKLLPYYNITVTNSINKAKELLE
KNEYDKMILDFFLIDGICSEVLFFMENKEIQTPVYVISAEDDFKIVEHLR
ESSNIMGVFNKRDTVLICDTIKGES
>Tmden_0934 Histidine kinase internal region
MYSVALHIKTEDWLYILAIGIVFAMVLSSLGYGLFEFSLLDGAIFGVILG
FSITIFSLIFVSNMNKIILPNVKEFYWLPLSILFSFLSGFLGTYFGVYVA
QNINIEIIPAFKNTLSTISVAIGILTYIIGALLYRFVKMRNQKDVIDKEY
VQSRLRSLETQLNPHFLFNALNSIAELIHQDPQKAEMAVLKLSSFLRNSM
NETALLNLGDEISNLSDYVELENIRFSQKIKLHVQRDIPACKVPKFSLQL
LVENAIKHGFKNLNVDLNIWISFDERTKTLIVRNDGDKMKSTKFGVGLNN
LKQRIELLCGGSIKVANSEEVTFLIILGDCSENINR
>Tmden_1641 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains)
MVKKRELAIFFLLFVLGLFLAYTYNDITKAKETIFETIEKHEIEQISLVL
QNIQKDIHTNYQIKDKDDLISVFKEQNNRERYEQILSIMLSSDVKYSYIL
YKDDTNKFRFLLDASKTDKANFNQKFDIDSKEYEIIYDLKEPQIIKQKNV
ENLYVTYLYPIISNGVVVGFFNIDFTTDIKMIILESIKPLEAFFTILTIF
IFIFMGVTLIQIFHYFMTKKKIFTDPLTGTFNRNYLDEIEHVLNLEKYSV
AMLDLDKFKIINDTYGHKTGDYVLSHVSTLFKNSIRESDILVRYGGEEFL
LLINKRDKTEPKTNICERIRSNVAKENFSYDGHDIKVTVSIGVHKHPALE
KNLQEAIKIADKMLYEAKSSGRNKIVIYDEKLNSLSLSSSSSKHLSFVKE
ALEEDRVTCYYQPIYNHHTGEIFKYEALVRIIAKDGKVIPPMSFMPHIKL
TNMHYKLTQRVLSTVFEKFKDNKSLVSININFSDLINPDIEESIVKALKS
NHHLASRVTFEILESDEIENIELFKQKIHLLHSLKAKVSIDDFGSGYSNF
KSVIDIEANFLKIDGSLIKNIDVNGKDFKVVKSIVHFAAQSNMQTIAEFV
HSKEVYEKLLLLDIDYMQGYYISKPEAHLILKDELFKTVS
>Tmden_1652 putative PAS/PAC sensor protein
MKEYVLKNDDFLVSQTDSKGIILFANDDFCKVAGYPLEELVGKPHNVVRH
RDMPKAAFKDLWENVKSGKVWSGYVKNMTKDGGFYWVYATVYPMYDAIRK
EQTYLSCRRKPSTQEIQEAEMLYKTLK
>Tmden_1880 two component transcriptional regulator, winged helix family
MQAIHKKLHSLTLLIAEDDESTLKWLSRVLSIYFKEVRVAKDAMEALELF
EQTPSDVIISDIQMPQVDGLHLLQKISLLSPSTTRVVMTAYNTPEYINRA
VESNVDFYLKKPIDIDEFLVAIASSRAKVDEQVFFLNEGYMYDYKQKLVK
KDEQSIKLTKKEVLLLELLLKNRKSIVSIEQIEHSVWEESVSDDAIRMVV
VGIRKKLYQGVIENVKGLGYRVE
>Tmden_1990 histidine kinase
MSKLLDTSEAILIAPNIYWVGMHLKNDPFQCHPYLIKNGDESILIDPGSM
IEFDETVRKVKTLMDMKDIKYIILHHQDPDLAAAVPEIEKLINRDDLLIV
THSRMSLLVKHYLIKSNYYEIDKMDHKLVTSSGFRLDFLTTPYCHSPGAF
VSYEPTSKTLFSGDIFGGIEESWDFYADETYFLKAKLFHQEYMPSKDIFN
YALAKIEKLDIELIAPQHGSIIEKKYINKLIQDMRELDCGLYIEEKYNRE
LIDTIKELQQKEIALKERDLLIFEQSKRAEIGEMIGNIAHQWRQPLAIVN
TSIAILQEKNRASSLSKEELFEKLEKIEKRIIYMSETIEDFMSYYSPDKE
KSWFKICDAIERSLDITNLQKSNTHVKVNLLITNEYKIFGLINELVQVLV
SIISNINDIIKIKNLTDVKITISIYKDDNYIVISIADNCGGIEDINLKKI
FDPYFTTKHKSIGTGLGLHIAKMIVEDNMQGYLSAKNLYNEKNEKIGAEF
TIKVKNED
>Tmden_1939 CheB methylesterase
MLENSQLERVILIGASTGGPGQIEKIIKALPKLKHTTIIIAQHMALDFIA
SFVKRLGEHSSNSIHIIENALRLRAGEIYICQGITTIHSTNVGLEFHLTC
SKEYKYNPDINALFSSFAPFVKSYKTLGIILTGIGDDGVSGCKELSLMGA
RTITQTQESAIVDGMPLRARQSIESIEIDDTNGIKNKIMEFCN
>Tmden_0738 diguanylate cyclase (GGDEF domain)
MQQANKKLLQIISNETKNSIKDMDVVTPAIYTEIFSKFALSHDTDITQES
KIAENLLSQKITLLTNLQESTSNNAKKLSENTDKALLAIKEKNESTLKDI
FKETQELQREIERLKKSVYKDELTNVHNRKWLHDYCLEDDSQNFKESGTL
VITDLNYFKIINDTYGHIIGDKVLIYIAGQLKKTKESVVRYGGDEFIVIF
NDSTSTEDVSSIMNKIREDVIKKSLFVKESSFKVSFSFGSCRFNKGDLLS
DVIESADNNMYQDKLEIKKRVTGI
>Tmden_0975 MCP methyltransferase, CheR-type
MNVAAYEITKSEFKELSEFVYKEVGIHLAEHKIMLVRSRLSKRLRELNLR
SFKEYLAYLNEDGSGEETIMLINEISTNVTSFFREQSQWDFLEQEVKVFE
AAKKRTLRIYSAACSSGQEPYTIAMFLLSTLKNPQDWDIKILATDISENI
LLKAMEGCYSAQDIGALPKSMLLKFFDKKNIMTKQGNELFYEIKPFVKSM
ITFRSFNLVYGNYSKIPQSFDMIFCRNVMIYFDKETKEGVVKNLSSKILK
GGYFFIGHSESLVTMKDGVLKLEKPSIYKKQ
>Tmden_1881 PAS/PAC sensor signal transduction histidine kinase
MMKKLDILKNMPKSIVLKSDGKVVLGVYGGKKSLKKLKYQKLKDIFDAKA
YKRVKKLKKKKSKSCNISWDGREYEVYFNSNIFYFYDITSYFEVESKLKQ
SLGELTSKKEELQAVFDLAANGISILDRNGMFLYANKFFQNMMEYTMEEL
YSHSCISLSSAEYAAPSKTAVEKAIEFGSFEKFKKVCVTKSGIHINASMS
LAYLQSRDEIIMITSDITEDIMYQDKLKKQVEIEVAKRTQQHEIMCHQSR
LAAMGEMIDSIAHQWRQPLNSLGIIVQGLRHISSQKNIDVKFLKEIEAEM
MQKLNYMSQTIDDFSVFFRITKQKESFNLLQSIEDAIRLIEIQLKNYTIA
IEITKDESLDLSILGFANEFRQVILNMINNAMMAIVSRSVQNGKIGILIK
RVKENFQIEIVDNGGGISKEDMPKIFNPYFTTKDKGSGIGLYMSKVIIES
HMNGLLRVKNTKDGAKFTIMLKKGY
>Tmden_1924 response regulator receiver (CheY-like) modulated metal dependent phosphohydrolase
MNTITVLAVDDEPFNLDLIELAFMDTENMNLIKAINGQDALDKLQHINAN
VILLDLRMPVMDGFAMLEKIKKDPIYSKIPVIIVTANSEEKNRALALGAN
DFLAKPVDTVELKLRTLNYTKLHKSQVALEELNKNLDKLVIQRTAQLHVA
LKLAQETEYEVSLRLGMASEYRDLETGMHIKRISHYSALLGKLSGMDEEQ
ERLLLYSSPLHDIGKIGIPDAILLKHGKLDDKEFKLMKEHTTIGGLMLKD
GERYPIIKAGQIIAQQHHEKYDGSGYPLGLKGEEIHIYARIVSIVDVFDA
LSSKRIYKDAFPLEKTIEIMKDGARTHFDPILLNLFIDNLDKFLEIRDSF
TDVDETPHLINLIEEYR
>Tmden_0715 diguanylate cyclase (GGDEF domain)
MQDLYEEKKTKSFNFFLLIAAIPIAGVIIIFSIMAKNRQDKIEFTKLELC
GIEVIAEIQKSVLDIQKIRALTSIENPNSDTLKKLEIKKEDILKGMNLIE
SKLSKIDDSITLKKELLSFIKFIKDSKLDSLNFDELTQIVENLTSYSSRI
SYHSKLILDENLDIFVLVNNVVFLFVELIEHNGQIRGVAVNTTNGNIDFN
QRHKIIMRLDKIDDKLKKLDLNLFLLGEVAYANKLKESYEDMKEAQRVII
DFTNNELLRDDAIAVDSNGIYEQITKNIDSVIALYEINLNLLRENLEKKL
KENQKSLIFIAIFGFLSIMFVIIINRIFYLNNRKYIDKIEELTITDGMTS
LYNRRYFDEIFDNYLRSNQRTKQVPVFIIMDIDHFKEYNDTYGHQAGDVA
IKIVSKVMKTFLKRATDMAFRLGGEEFGILCSGINAIEALHLAHDIRKGI
ENEKIEHKSSKVNEYLTISIGIIVIEEGKINSTKEIYRCADKALYKAKEN
GRNQAVLYDAKMFCDD
>Tmden_0987 response regulator receiver domain protein (CheY-like)
MDKEQVKKLRAICRDISVLYVEDDISISAQLEKLLRKIFNNVEVEKNGLS
GVQSYTKNRQDIVITDISMPVMDGIEMCKRIKLINSEQNILVTSAHNDAE
YLVKLIDIGVDKFITKPIDMGSFLSNISKIAISIYREKRETVLESRIKAQ
QNLQKELLNGIIFPLAYFDEGEIVYANSSFKKQFFTEIDAGDFSRFRLGY
LFENKKYVSMSNSELVQEISNSDDKTYLVMDVNKKIVKKYSISVTKFQNA
KGCLLSFVNLNALNEEINRFSEQVDYFPKRESFSQALLEPKKSTKENYEI
FCVGLKNTKGFIDKYGGAKMHSIFNSLAKSLKKEFSAEVQSKELSIYLFE
TNRYIFLVEKNLDNSAIDKRLSDFGKKYNYAFGSGLPLELSFIKENIKNT
QSIGDILENTEGMLYTLSTI
>Tmden_0989 methyl-accepting chemotaxis sensory transducer
MFNNISIKLKMVLMLIVPITVILVFLGIDGYKNYNEVKLLKQIEEMVAFS
QKSSSLVHNLQKERGASAGFIGSKGEKFSSELQDIRKDTDATHEELSKFY
SSMNKIDYAASLQSKMEKAVANLSKLKEIRDGVSSLGVAVGVPVTYYTNV
NNDFISSIEEIAKMSSNAQMNNLTNAFVNFLASKERAGLERAVLSSTFSR
DNFAEGFYEKLIGLLNAQDIFMNKFLFLAPEELIGFYNQTMGAPEVKEVD
RMRKIALSNPNGGFGIDATYWFATITLKINLLKKVEDEISLHLKNSISEL
QDNALRSMIIGIVLSFVILAFVAGFSFIISNGLTSRIERFKQEIDEIVSS
KDFSKKITSCAADEIGFIQQSANHLACVANTAIEEAKISLQKTQEHSAES
EKRLEANNLTLALTELLNEGAVSGVGSVQEGLSNNMNALVEINDKNARTE
IIVEEVKNSTDEMVHSLSNISQKMNSSKENADQLNSSVIEISNVIALIKD
ISDQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQRATNEVELN
INLLKQNSSSMQEFSEQMSVEVSTSLEKLDHFNGSLHDLVDGAKDIQLAN
KKISNELFITLAKLDHIAFKLSGYGAVFKDDHNFKFSDHMNCRFGKWYLA
AGKEAFANTSSYPKVDPIHKVVHDRVRSVPDYIQDGVLKNASKIISSFVE
AEKSSKELFGVLDDMAEEIK
>Tmden_1555 putative CheA signal transduction histidine kinases
MKNCLIHYPSELISKFSKGNVSGAITGNILVPLIIVFSFNNIIPAAQLYI
WFALHVSVFLARIIFRKKISSHLYVYSSLISFSSVLYALFAWMSFTYGDD
IYLLLAGMIVASVAAASMISLVSIFHIFVLFVTIQMVGLIVVFLLNGQNI
FYLSVLLVVVFLFFILLNGYKQFSILKEEIKLKKQVHDLLDNAGQGFLSF
DENLKCQSSYSQECKRIFGIEDIEGLDISNLLFSGNSLNGEIFIDGISRA
CASEDEDIKEMFLSLLPKEEIIGDKSIKIEYKNLKKNRYMVILSDITNTK
GLTSKLENQYQIQKMIVAIASDKNDFIELKDDFEQFTNNISNVSNTNSLT
IIRDILRELHTFKGIFAQKEMLHITAYILEVEKKIRNLCAGEDIISTLIK
ADLHSVFEEDLTIIRSILGDGFLTSPKSINVDIDSIDDIESSLIALKKTL
SANEQKNLNNTLTKVQRLKHESLKHMLNPFVSHIKQLSSALEKEIYPLEI
KGDEKIKIDSKFKPFIKSLVHLFNNCADHGIEDIETRAMLNKDEVGTIKC
SFEIVSNMLIIQISDDGGGIDTKELSLTAINKALKTKEELELMSQEDKCK
LIFTDKLSTKEDISMVSGVGIGMGVIKENLEKLDAKYTIENIPQSGVTFT
FYIPLNINRDEDISNEKKIENICDNILTQIEVFLKNSLKLEIKSIKQITD
VSIDKSYAQIDLYDTFDGNVIMLFSDEIIEFMSSALIPKNFDKTDIAWMS
KELPSEVLNTIVGLSLQYFDKSLKDVKMTPPLYLDNTDLTKALKDAKNKF
IQEIETSSGKIVYIVFEKEKP
>Tmden_0587 conserved hypothetical protein
MKFEVIQNEYSALLKEIQSYFKNSQNSIHKARNEIKIIDFKQKSLVIKSF
KVPHLINRVVYTFFRDSKAKKSYENSVKIAQFVPKPIGFVELKKSGLLHE
SYFVSENFEYDFTIREPLLESVFLDREKIFKAFAEFTFKLHVEGIFHLDY
SPGNILIKKESDGYIFKIVDINRMEFKPLNLDKRLKNFSKLWAKDEDLKI
IIKEYARLYKSDEERSIKIALQYSQAHKNRKNRKKRLRGEAVVD
>Tmden_0044 putative PAS/PAC sensor protein
MIREMKEDDFIVSKTDLKGRITYCNQIFMEMAEYSEEELLGKPHSIIRHP
DMPKAVFRYLWETIPKKEEVFAYVINKTKNNNAYWVYANITATLDESGNI
VDYYSVRRKPNPKALEIIIPLYKKMVEVEKSGGVDASFKILTDILADKGM
VYDELIISLQNQ
>Tmden_1672 response regulator receiver domain protein (CheY-like)
MKLLVVDDSSTMRRIIKNTLQRLGHKDIFEGGDGVEGWGVLDTNPEIDML
ITDWNMPEMNGLELVKKVRADARFKDLPIIMVTTEGGKAEVITALKAGVN
NYIVKPFTPQVLKEKLGAVMGIDV
>Tmden_1036 diguanylate cyclase (GGDEF domain) with PAS/PAC sensor
MIEIRYPDVLLDSLENGHMIIDEHFVVSYWNRWLAINTQINKEDILGKNL
QEFYPDINYKVLYRKIKTALTIGTPTFYDTNSSKKFISINRNKVTTSSLK
LMQQQVTISPYIISESRVMISIYDISELFEAKLLIKKEMNKVNKLNEKLE
ADRDIIDKNIMVMKTSANGFIKDVSSFFCDSFNISKDELIGKNVSIFKSD
DISDIVYRNLIETLKNKKPWNGELKYKTSKNQEKWLQSRVVPILDLHGEV
HELNAVYHDITNEKLLAELYITDSLTKLYNRAYFDETINMIVKHQRKADS
DFILVLVDIDHFKLINDTYGHQVGDEVLVAIAKTLKGSLRDNDLIARWGG
EEFVIMLKNITLNEAKTIIEKVRVNIQNSIIRDNIKVTASFGLTKYIINE
DSKEIFKRADDALYEAKKDGRNRVVVR
>Tmden_1058 response regulator receiver domain protein (CheY-like)
MSNIDLVQLTQETKKLSAMVVEDEKVANELLSSTFKNFFSDVRSCFNGKE
ALETYLKSAPDVVFVDIIMTEMDGIELSRKIREINPTQIIIVISASNDIE
KISESIEVGVNSFIQKPIDTKKIIELLTSVVAMVAKKKKIETKTFSISLP
LDLYEIVNENAKAESISKNAVIIRALRSFYE
>Tmden_2101 response regulator receiver (CheY-like) modulated diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)
MNILNKLTLLYKYDDGDICNSLMPYLSKLFEVVYKANDLDDLLKISKENR
VDVILFEIAKEDKPTISTLDLIHKESIAKGIIILAKEESITSLQKAIEIH
AHSYILNKKENLQTILKSIKSLSIKIDKELKESLIYDKLNKQFYELTRQY
EIINKNIFLSYSDLDGNITDVTKAYLDFTGYCKEELIGKNHSVLKHVDLK
KSYVEDLWSTISKNIIWRGEFQNIKKDGTLFWIKVVIEPLYDENGIKIGY
CAIKEDITDKKRVEMLSVTDMLTSLFNRRYFSEILVKELGRAKRNMLNFC
LIIVDVDYFKQYNDFYGHQAGDNVLRKIAECLSISSGRGNDFAFRIGGEE
FAIITSNMDDDDVMNYVENIRLSIENLKINHEKSKVSDYVTASFGVMNFS
PSIELLSSDDVYNIADKNLYEAKKDGRNRVVFYKNKIDKNLSCSIDKLTK
LPDKAALFEAVHELEDRAMLMIISLNDFTHLKEQYDNKLLDNIIIEKSKD
LRRTILDKETFLFRLSTNEFAILVTRQSQFEKYLSIMEYAILQNRVCEMV
YKDVEYKIVINYTIGIAYGKKKLLNMANMALIKASSTTKGFYVYCGEIEQ
KEIRKQMLDKLKIYKEALDNDKIIPYFQPIVDVNSGKIFKYEALARLIDE
SGNIVTPYMFLDAVKEDKTWEYFTRQMLHKVFDIYSKNSVNLSINLTYEN
IASPSLIAYIKNRLDLFGGQRITFEIVESEDIKNYNLVEEFILFVKSYGC
KIAIDDFGSGYSNFTNIVRLNTDYIKLDGTIIENLAKDKNVELMAISLIN
FAKKAGIKTIAEFVSSKEIALHVKELGIDFVQGYEYGKPELAEYYGLKS
>Tmden_0415 response regulator receiver domain protein (CheY-like)
MSKELVILTVDDDLINLKLLKSMLMKNPDIKEIIEAQNGADAVAHIKSRD
DISLVLLDIIMPIMNGLEVLRVVRSDKNIEQIPIIVLTTDETKKTEALEL
GANSFLVKPIRSNELSEKMRALLV
>Tmden_0208 response regulator receiver domain protein (CheY-like)
MSSDVDTSLLDCLSSLTLLCVEDNKTTQLIYHSIFKNITKRVIFADNGKD
GFEIFKTQKIDIIITDYEMPNLNGIEMTKLIRELDKDIPIILVSAVQEID
IIVEALKLNVNNFLKKPIILTEVIQAVEKVSKILIADNYLREKREKKLKE
LETKGKYNSLQEELAFAKELNIIRNDFYYQMHENSSIALIDFFYKPLDVL
SGDSYSAREIDKNMQLYFIIDGMGKGLSASLSSMLLTSYLNHLIDKRVNN
FDFKSLINSAVEYIKPVLLEDEAMSADFMLIDYKNSKLHYAKFAMPSSLL
QTTNGKIVKIKSNNAPLSKYIKKIKISSFNISNILKFLFYSDGVVENSIR
EKDKTYANYLQSDFLASFTKDELREKILWRIDKQEDDMTFIFINRFNLMK
YISNVQNVFDTSLDAIEKANEWYGDFWSCTSSDYKLIYNAGVVFNELFMN
AYEHGNLGLDAQMKHKLINDDNYFATLEKLEKTCNKKISVCINIIEYNSN
KYVTTAIRDEGAGFDTQILSDIFRNRKNFNGRGVYISRQASLGIYYNTKG
TSVLFLHKLESEKA
>Tmden_1453 cyclic nucleotide-binding domain (cNMP-BD) protein
MSILDQRKLIESIHPFELLSSNAMDGLMKKIDIAYYPNQTLLVSPTISSI
AFYIIIKGSVTEYIDEEIHNVYGAGDSFDADALIYGKTKAKFVVDEDLIC
YEIKKEDFLDLMQDKEIQGYFLQDFITRHKQLKDYDTQSELSPFLISRVS
DIFLHTACIVEEDETIYNALIKQEKLQSKVILVKEQKSYSIVTDTDLRKK
LLLGDNDLSKKISSISSKKIISIDINDFLFNALLMMTHNAIKRVVVVDGE
KIVGILEQLDLLSYFASHSHLVAVQIDKAQNIDDLKALGHDFKSLIITLR
AKGVKVRYITKLIATLNDKIYNKLFEMCVEPSLREKCALIVMGSEGREEQ
TLKSDQDNALIIQNSVDVELFHEPMMRLNGYLLELGFPKCSGDVMVSNEF
WRKNSSAYKDLITKWTYDMSDESVKNMSIFLDAKCIAGDCSLLDELKEYL
HSSFHSRDDVLAHIAKAVLSFETPLSLFSGFVLQKERKDKLDLKKGGIFA
LVHGIRTLCLQYEIKETNTVERIKELNNIGVVDKTFATELIESFDTLSSI
RLKAMLEAKNIDEANYINPLNLEKNQRDLLKDSFKVINKFKKFMSFHFHL
NMVV
>Tmden_0884 two component transcriptional regulator, winged helix family
MKILLLEDDVILSEILYEHLSEKGYDVSSAYDGEDAYEKIINSRFDFMLF
DVNVPLLNGFELLRLLGEQHVNIPTIFITSLDSAHDLKRGFDLGCDDYLK
KPFDLVELDARINHLLRVHNLNSLHVVIDAKSYLDKLTYELVKGEQRVKL
SKKDFEIIEYFLSHRERIISHDELAANIWLDSETPSDSTLRTYIKNIRIY
LGKDFITTIKGVGYRVNI
>Tmden_0929 adenylate/guanylate cyclase
MKKSLAQLFVALLIAFMSTLAYMYTSEFYLPFENKIKDLMFKARGEIVGD
KEIIIIDIDEKSLKELGQWPWSRDVVSKLLQNLAEYEVGIVGLDIVFAEP
DNSSPKKVFQKLGLSTQGVVDYDALLAETIAQTPTIVGYVFALSNDGIAP
ESSPKSNAIIVEQNRPKSSSLVKPYRTILNIEAIQESAYSSGYFNTIPDN
DGVVRSIPLVMEYDGILYPSLSLEMVRIMLDEKKITIVYDDNGASHVELG
ETMIPTDFFARMQINYRGKQNSYRYISAVDVYNKTEDASHIAGKIALLGT
SAAGLMDLRSTPFDSVFAGVEVHANAIDNIINADFIAKPIWSVGVDMASF
SILALLTFAILLLPSAVLSFISLVFINAIIIGVHYYFMVYEGAILHTFLL
LVSVNALFVLGQAINYFLEIRQKEMIKGKFASKVSSAVMDDLLSVEGDIF
AGKEREISIFFSDVRGFTNLSEAMGDPRSLIHLMNAYMDPMTDIVIKSKG
TVDKFIGDAIMAYWNAPNEVENHADVAVSAALDQLHALRELNEQIRLNPE
FKNAVLMSDKKGIPIIDIGIGINTGVAIVGEMGSSSRSDYTVIGDPINLG
SRLESLCKYYSSKLNISNFTKEQLKGSYIFRFLDLVTVKGKSVPIEIWQI
HDYDDALETPLYNVTKEELEEELKIYHHAIALYKDTKFSEALEIFETLDA
NENKTNKTIYSIYIERCHHYIEMPPINFNGVFEHTSKG
>Tmden_0836 diguanylate cyclase (GGDEF domain)
MHYYLNLKNIFLLLALSLTYIILGVMSIQFVTMPSGIAIAWFPNSLLLAL
FLMKNIKEWKYYIPFFIVAEIVADYQVFTLIQALQFSFINLFETMFGAYI
IKKLSSNDGAGFTNTKYVLLFFLIGLTLMPAMSALFGAIVYHTQIDTQTT
FFEFWRIWFFGDSIGILLLTPIMVLLKENYKSLKNYDFNIQNISIALLSI
YLAIVLFSFTDINFMLPTTPLLFVLLLLWIVYKQGVLPGMIMALLITSIA
IYYTSSGLGPFSIFGLKGTTIYLQEFIAILVITTLFFGVLHQEINESKAK
LEELNKNLENMVKEKTKSLMEANQKLNNLASKDSLTNIFNRRIIDEFISK
ETIKSKRYNNSLALIMIDIDHFKEVNDKYGHQVGDEVILSLVDIISKNIR
ESDIFGRWGGEEFIILLPETNLNQATIVAQNIRKKVQEYRFDKVGQKTIS
LGVSEFNSNDDSTVFIKRVDDALYKAKATGRNRVVSL
>Tmden_0531 two component transcriptional regulator, winged helix family
MKNYLIQIIEDDSSVKKLLEITFREHNLNYISCDNKKNAMMLFLTHSSDL
LLVDLGLPDGDGKEFIREIREISKVTIVVLSARDDEKEIVAALDAGADDY
ITKPFSVNELLARIRANLRRSISGENISSKITCAELEMDIASRDIFFKNE
QLKLTPIEFELLKYFLLNANKTLTHKQILKEVWGVGYQSEMQYLRTYVNT
LRKKIEQNSTRPTYIKTESGIGYRFCCNN
>Tmden_2088 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)
MSDKTYKLVDILNLHPSKVAVEERLNLALNFFESTNEGILIANREGLIKF
VNRAFCEITGYTQEEAIGKKPNILKSGIHDIAFYKSMRESLEKNGYWKGE
IWDKRKNGEIYPQILSISKNKNSKFSENYYMSVFTDISDIKKSEKKVYYN
ANYDSLTKLPNRTYFNKELEAILKEADKENYQVALYFIDIDKFKEVNDTH
GHNVGDKMLINVSKRLLNSIRENDVIARIGGDEFVLIAKNIKSEENVKQL
ASNLKKKIKEPMEVDNQIFHVGLSIGVAIYPQHGISSEELLKNADIAMYE
VKKSTRDGFKIYDKLMSTKIAMAISIQKDIRKALEEDMFIVYYQPVIDMH
TNSIIGAEALVRWNHPQKGILEPESFLQYVLSGDVGREFGCMVFSEILTD
LKHINETLPKSKLQISVNISKYQLSNSTFCFDFLNIFERNFINADQLELE
IIETEIMQNREMIKKNVEELSLCGFNIAFDNFGTGYSSLSYLRDIKVDKL
KIDKSFVKNMLENEKDLNIVKSIIDIGKLFDLKVQAQGVETKEQYIKLKE
IGCHFSQGFYHSQPLCVDDFMGYYNKI
>Tmden_1366 histidine kinase
MLGLYLSSTLLLIATLFGSYYFYKQDELMHLEEDTLKEYSSKLQEKLFDV
HENGDDKYMYPRFKEFESAIYDIDKNLIFSTIDSKIETLDNKLYFKEAKT
YYVSSMNPHYLGAAFMVVQKNTKSLNILNDLIATAIFVIILTFITSYFLV
RAVLKPLRDNLRLLDNFIKETTHELNTPITTIMANIETLESKNCDEKSLK
KLLRIKSAAATISNLYEDLVYLLLNHKISSQNEELNLSQILHNRVSYFSF
MTNAKKLNIIVDIDDDVTFFADKKKIEKLIDNILSNAIKYTNKATTITIV
LKPSYLLISDEGNGMSQKEISVIFQRYKRFDKTQGGFGIGYSIIKSIIDE
YNIDINIESKLQKGTKVTLKW
>Tmden_0965 Cache sensor signal transduction histidine kinase
MQKNISLKSLIYKSYLSSALVPVFAIELVLLLLYFGVTFFISQKSQDILL
DEAKLALNEIASREAGHIDMLFSEVKRDMAILKRDHERFFTLNECSSQKV
KAEFGRHKNGALYKLVDNGGSSIYAPKDFDATPKNLKKIECSEFIDPLMK
SIVDTNPIITQAYINTYDKINRLYPFMSDAATQYGAELDATSYNFYYLAD
ANYNPKRKDVWTSAYLDPAGQGWMISIIAPIYNGNFLEGVSGLDVTIDSL
IKNVLSLDIPWSGSAFLIDKDGTIIAMPKRIEELFSIKELKGHTYTSTIS
TTIEKPKEFNLLKNSKEMESFFKKATPIDKFTIKGANYIISQKIIPQTNW
RLMVVVDEFIIYRPIMEFKSQAQIIGYVVIALMIFFYLIFFIYLMRKSNA
ISEYIAKPINELSTLTSNLGTKPNTQLRETGNIEEIYKLVQNFNTLSNEL
DDRTNAYIESQMREKMKEKEALSAYREGLLESAGGYLHNVGNSLAILDSK
LFVLKSSASSLQKSELGFNKVIEMVQNSHAKGEEKVSMEVFLEAFKEALS
DDITSEILDVVDGIERVKNHASEMIKDQQDRLANRDGSENYVYSFSLNKM
LSELIEDYSLEFFRFNISIKVHENDEVVVQIMKYRLQSGVANVIKNAIES
ISLSKNSGNGIIDITIKREKNMVLLIVQDNGCGVARDDIDKIFGFGYTTK
KGGSGFGLHTLNNFLNSIGGTINITNNESENGATLMMEIPINE
>Tmden_0043 methyl-accepting chemotaxis sensory transducer
MHDEIIKALKDAAAGKLSARITRIPNDNSKESAFAWSINDALDQFEAFMR
DVQTSIESAANGKTHRSTDPHGLHGIFRTTSQKLQLAISSISLGHETKIK
SKLSNDFSVLGGGVSGGLEIIQHDIAIAQNGSDEISKVSEKTALLSERSL
ENVKDISQKLATLVDSISSSHDVIINLGQRTRDISNVVGLIKDIADQTNL
LALNAAIEAARAGEHGRGFAVVADEVRKLAERTQKATQEIEINISTLQQE
SNEMISSSENISEIATESNNVISEFEKTFEELNSYANKSSEISTAINNQL
FTSLVKVDHIIFKSNAYSTLLSSNTVNTFIGHKDCRMGKWYTGLGADKFG
HTKTFKEIDSVHANVHDYAIKNYEFVKAKTVLKGENPNIIIKNFTEMEKS
SDLLFKKLDEMVQEYTKSGAK
>Tmden_1010 signal transduction histidine kinase
MRTVFFIFLITFHLFATTSIAQKSAQLGLTQEEKQWLIDNPRILVGMDPN
YAPYEWIDKNGNHIGVVVDYIHELEKILDVRFEILKNKSWDELLTLAQKG
ELDMLTSTVKTPERSKYLTFSEPYHIAPTIIVDNKKGAFIGSLKQLSNKR
VVVEKGYFMGEFIKNKYPKIQLVLASSTKEALEMVTDDRADAYVGDANIV
DFVMRKNDFSTLRFSGQTEYVSYQAFALTKGNEPLAPILTKAMATTPKEE
FDAIFYHWLSIDNSTNVKTLVKYALLLLVILAVVGYWIYLLRREIKYRKL
AEKKLKASETLYRELTEDVTDVIWKANSNHILTYISPSVEEKLGFKPEEL
VGRHVFEMFTPEGVAIVMERIKQRQENQEQAVHDVHSIFEVQHKCKDGSF
IWGEVVSKAVYDKNRNIIGYHGISRDTTMRKEMEREKELLYQELDHRVKN
NLQVISSIVSLHSCQEDISKSLEDIHNTISAISLAHDKLHQDELHKTLEI
KHYVSALLDNLLASSVLKIQKEIDSTQIYLGASHSITLGIIINEFVSNSI
KYAFQSISSPKITLTITQDKEFINVLISDNGIGFKGKKQSSGIGMDIIKT
LAKSRFKTDVIFFDNNGTSLTFKIPL
>Tmden_0317 two component transcriptional regulator, winged helix family
MRILVVEDDEKIASFIKKGLQEESYSVDVTSNGYEAIYLVETNSYDIVLL
DLMIHGLGGIDVCKNIRGKNIATPIIMLTARDAIKDKVEGLDCGANDYLT
KPFSFEELLARIRSKLRTTSTLSSTIAIADLTINTARREVKRGDKKINLT
AKEYALLEYLARNSKKLLSETIIKENLSDMAEVSMSNIVNVYIYRLRNKI
DKDYEPKLIHTVRGLGYMLSEKDV
>Tmden_1951 response regulator receiver domain protein (CheY-like)
MNQTKVLIIEDNRLSALKIKKLLKSSGFEVCGIVSNASDAMEIIKLCRVD
GIIIDMETKFKLNGIEIVSFIHKTENIPTIVVTKHHNYQILKEASKIHFI
GYIVKPYLDSQLLKEVKLISIRLGLITPPQMTSLT
>Tmden_0979 histidine kinase
MIKNIIKSRYLKTVPTLLFGGWILFALFFSIEAKGLRDSFQEEIDMAAKQ
RMFTQKILLESHKVYMHDNSSSKNTLLRIYTQMRENTYFLHEKYFRHDEK
LIGIKSEVEKLLSSVEQFMESNNRENFDALQTSAEITFERVSEVVDIVKE
NFAARQKRLIILNLFFLLSSISMTFLFVRYMFFPAAKLAANSQDELMMLN
KELELKVEERTLSLQRSHNYIDSLLQASDEAQIVVNNAFRVIDLNSNAKN
IFANISKGIELSKLLEDVKQKKEIFTFISFLSDYDANLKSDKVFFYNRKY
YKMRYKMLNLSTFIITLYDITHEIQELKRRDAIYNSQQSIVVVTNGKNIK
NINTIFFSEFGFANLEDFKSKHSCICELFRQKNGCEYLTREMEGMTWNNY
MRQKSKESYQVLMINKDGIEKIYNVKSSGNLFSEDDYEDEEVIVFNDITE
LEEKNRILVMQSKDAAIGEMMSMIAHQWRQPLSVQSTILSRIRVMREMDM
LDDTSFDSALDKLNMQISYMSKTIDDFREFFKDSDYLESIEVQDIVYSAK
NLVEVILNSKNISFEVDFRVDREMKVETMLSKISQVFLNIYKNAIDQIGS
KNIEDGQIRVNVYTQEDELIIEVCDNALGVDESIIDKIFEPYYSTKSKNG
TGLGLYMSKKIVQESLGGKLSVKNVDKGACFIISLKI
>Tmden_0282 response regulator receiver domain protein (CheY-like)
MKNIVIIDDESDILNMLERHLSRDSEYKVKTFSNPINAIASLPKDTDLIL
LDIMMPQMNGLDALPKLLEVNPKTKVLMMIAYSTLDKVLNAHRYGATDYV
MKPFASLDVLSKKIKEVLRKN
>Tmden_0967 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)
MKTIDIFPWSNHFNTEIKIIDEQHKKLVIILNRLATHIAYSDTDDDLNDI
FDELIDYTSYHFETEEAIWHKYLPNDELDASHKVVHKTFVDTVLRLKNEQ
NRESLSELAQEALGFLASWLASHILETDRHMAYIVFAIEDGLDIASAKKY
ANERMSGSTRLLIDIILSIYSTLSSNTLDLMRELKMRENLKEKLIYQEHY
QRALIDNFPFLVWLKDEKSRFLALNQPMAKACGFDLPEEVVGKTDYDIWP
KELAKSYRKDDANVLASGESKTVEEPIVTKDGVIWSETYKSPVKVDGKVI
GTVGFSRNITSRKELEKNLLQERDLFKHYLNTVEAIIVSLDKEGHINLIN
RKGCEILGYSEEELIGKLWFDFCLEQPEGMKIIYPLFLKIVSGGLEGSEY
FENKIVSKSKKKYLIAWHNAYLLDDDKNIIGTLSSGEDITLLKEQQKHLE
HIAHYDTLTSLPNRTLLSDRLKQAMLQTQRDKLFSAVIYLDLDGFKEVND
TYGHNHGDILLKVLSSRIKQILRDVDTIARLGGDEFVIVLYDIKNKEDCF
PMLNRILSTIAKPVKSKEITMQVSASAGVSFYSYEDIIDADQLLRQADQA
MYQAKLSGKNRFHIFDVQLDKHIRSHHESLEAIEVAIKNREFVMYYQPKV
NMRSGKILGLEALVRWEHPLHGLLSPAHFLPTIENHKLSVELGNLIINTV
MGQIQKWKQEGHNLVVSINISPMQIQEANFTAKIINLLKNYPEVKTSDFE
FEILESSALEDINHVSRIMRECNKIGISFLLDDFGTGYSSLTYLKNLPAK
QLKIDQTFVRDMLEDTDDMAILEGIIGLANAFRRDVISEGVENIEQGNML
LRLGCEEAQGYFIAKPMPSQEVMKWINQWTPPAQWQNIVKIPRDDMPLLY
AITEHKIWIKDVMAYLKTDTVKYPKLDYKECRFGTWLYTQGVQRYGKKDG
FKEVVSQHKKVHENINEIIKQHKSQTLKNIDASIEEIKNYHNDFLKVFNK
LIIV
>Tmden_0966 multi-sensor signal transduction histidine kinase
MSSFKIFAIDDEIHILDFYKNILKQKESKAKNFFDSLESKEEIKDEFDLY
TFETPKEYLMALQECYENEDKVAVSIIDMRLPQMHGLEVAKRAREIDENM
NIIIVTAFADFSVDEILGRIEKNVYYLHKPFRHDELLVLVTTGVRNYQTN
CSFSEVMNDIAIDATQDGFWDWNPITNEVYYSPKWKQMLGYSEEEITNTL
EEWSSRVHPDDIQDVMQTLKIHLEKKNDYYISEHRIRAKNGNYVWILDRG
KASFDADAKPIRVTGFHSDITKRKELEEQLLSGNKELESKLETIINSQMK
LENTNAQLEERLMQEIQKSKEQENMLLKHVRQAAMGEMISMIAHQWRQPI
STISIVADNILMGMMLGDETKEDTEEGLSVIKKQVVHLSQTIDDFRSFFA
PNKSKEHTFIKDAIDSALSIIEANLKNSNIKIIKMLEDTKAINIYKNEMI
QVFLNILKNANDALLYAEIENPTITIRSYEDESGITVSIMDNGDGIKEEI
IDKIFESYFTTKNEKNGTGLGLYMVKTIVEQRCQGTIIAKNSDDGGAEFV
IRFTFF
>Tmden_1358 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains)
MNIPNRTKRNTLMLALFILLSSSLIAYLFLNYQLKKSINSEFERVVESTH
RLFEINLKDEKEYLDISLDELLLSDGLSKAVANGDYKAIDSIVSPYYKKL
KQSKKAVNILTFRSEDGITLYRAHKPEFFGDKVSQQRKLIADTNFFKRSF
DGFEVGKFEMTYRVTRPIFYNEKYVGNLELGISPEYFLHELNAVFKTELG
IAIDKKLLDIFSNKEEKGTVAIDDRYVLIDNKQNLKKYFMDENRSESLYK
VSMNISLKNHLSESLGHLIVGFDIRDIAEKNTNFIYMLFFMIALMMFILV
GILHFGFNKILKHFSKQVYKDHLTNLKNRYALDDALTSQKSKVLILSNIK
EFSLLNELYGVHVGNETLIQVAHAFKEFAQEHSFEVYRISSDEYVLLKND
ENFDEDSYSKLTEELHCKINSLNIVIHGVDEIISIEIYSGIAHDHAHSLE
DAQMALKKAKKNSLSYMIYSKNVDTKESSQTILNIKKTIKHALEHKNVVP
FFQPITDKNGTIVKYEALVRIVEFDNGKKNILSPAEFLDISMKSGSYIKI
AKEMLEQSFSIFASRSEKISVNFLPNDFLNPSIMEALIIGIEKFESPNRV
VVEITEQEGVENFERLLHVVKKLRDIGILIAIDDFGSGYANYAHILQIKP
DYLKIDGSLIKDILEDNESRILVQSIVRFAKELGITTVAEYVETKEIFEL
LKSYGVDEFQGYYFGRPTDLIGV
>Tmden_0964 two component transcriptional regulator, winged helix family
MENILDENIYSPEIDLYEFKEQVIELRKYTKEINILIAEDYIVLQQSLFK
IFTPLFKEVGIASDGAEGLELYKKKVANGEKYEIILSDIAMPNMNGVEMT
KKIREIDDEQIIFIFSAYQDSEYLLELINLDIRRFLTKPISLETLFHELL
ITCRAIYGKKDLSNKITLRSNVYYYTSERELYIDEIAVKLSNYERLILEF
LLSKINSTVSNIEIINYLYFNGVDVELENVRKIVYKLRKKLSNDLIENIH
AIGYRIKQ
>Tmden_0981 methyl-accepting chemotaxis sensory transducer
MFKNLSIYKKMNYFIVMVSSFVFIAALSIYFAMSHIASKYDHLHNNSMMG
ELSTLKIEKNLNYVSRLSRDIMLGGNFDKNIKKLKSTIDEIELLFNDLHK
TIEIDSSRKLLHEAKESTMLFLNSSYNMMKSLSANEIKYEKENVYAAYSQ
ELTPYANASRESFQKLLDLKADELERDSNELGVELNFFKYLVLVAGIIVG
VAVFVLAIAIRKSIISGINEFTLLIGHVAKGDFSHKQNSTNEKDTELGIM
GKELSSLITHTQNLISEINETITEASKGVFEHKISSVGMDGEFVKAIQSV
SMSIEFMKLQHEKSQRDIFNAKISTKSVNVSESLSLIISDLNGNVEDLKI
ITSATKDASSLANESREDISDVVNELNALSQRVTINNESVLEIAQRTNEI
TSVIELITDIADQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTH
KATGEISISIKSLQQDMHEIQESSSNMKETVDKSTNKINEFEETLIKLSE
NSLKMVNYSYGMENSIFIVLAKLEHILYKSRVYNSIISLHKMLDAQDTHE
CELGVWYGGEGRKRFSSTNSYKLIATPHEVVHKNANLNLAFIDKDSEKNT
LKNSQKIIDNFDVMESASLEMFALLDKILQESSSV
>Tmden_0139 hypothetical protein
MQEEEILGDTVEYLDEELQKAIAAVENIAARVYEGTLDAYEGFVQTEEYN
KKIVDIGNKLKEKGIDITKIAEYQ
>Tmden_1928 putative signal transduction protein
MSKIAIPDSFPNLPSSIKKIQKMFSSNEINIHSLITALKEEPLLCANILK
LVNSPYYGLKSSVASIESAVTLLGVTVLRGIIMATILKKSFPLDLSVYNI
SAQEFDKICILRTRFLKVWLKDEDFDIQTLSSVAFLMESGKIITSYEIIK
NQLSSAFIELSQKNSILEAEKELFDANSYEIASLLFEQWEFEESFIKLIS
NIPNPSTREQKILHVLSVAISVEGVLEEKNIGLAIELINEYGFDKEKFMK
ALEALREESL
>Tmden_1530 CheA signal transduction histidine kinases
MDEFQEILQDFLVESFELIEQLDQDLVELETRPDDLELLNRIFRVAHTVK
GASSFLNFDVLTHLTHHMEDVLNRARHGELVILPAIMDVILESIDLMKAL
LHTIRDTSADSGIDVSGCVSRLDKCAKGETNIEVPQTTISTPKATQSEPK
EVKKEVVVETQESDELDYDNMDADELEAEIERLLKQRQEEDKIKREQKAT
NEDGATSETNGTEDEYVPVAKAPAVVTPARRPSSLGDDSDSNDDARAASP
AKKQSNVEQTIRVDVKRLDHLMNLIGELVLAKNRLIKINDDVEERYEGES
FLEELNQVVSIVSIVTTDLQIAVMKTRMLPIGKVFNKFPRMIRDLSRELN
KKIELEISGEDTELDKSIVEEIGDPLVHIIRNSCDHGVEMPKIRLEQGKS
ETGTIKLKAYNEGNQIVIQIDDDGKGLDVDMLKRKSLERGLITEKEADNM
SDKEAFALIFKPGFSTATVVTNVSGRGVGMDVVKTNIEKVNGIIDIDSEL
GIGTSMKLKIPLTLAIIQALLVGVQEEHYAIPLASVLETVRISKDEVYTV
EGRSVMRLREDVLSLVHIGDIFEVERILDSSEYAYVVVLGLGASKLGLIV
DTLVGQEEIVIKSLGEFLKGIEGIAGATIRGDGGVTLIVDVVAIMDMAKH
VKASAIIDSTSDAAMLTLEKTKASDYKIMIVDDSKTDRTIMRKALEPLGV
TLVEAGDGQEALAILKQGDHNFDAMLVDIEMPRMDGYSLAIEIKKYNRYK
NLPLIAVTSRTGKSDRMRGVESGMVEYITKPYSADYLMSVVQRNINFRSE
FLK
>Tmden_1394 transcriptional regulator, Fis family
MDAKNIATSASWAQAFKTATLLKTLSVNALVIGEIGVGKKTLASYILPEA
PVFDASDYDALLIALESVDSVIIANLENSPNIKKILELIIINNIRVIATA
SSSFKNDIIDKIFSIKLDIPSLRERPEDVAFLINRYINEATSLFGLSKTL
NINDIKPDLSRNSYSLKKQIMIQYLLQNINENELMNIIENYFFEKLGSNS
DYKNFLHIYEVPLIKAGLHKFKSQLQLSDKLGLNRNTLRKKISENSKYL
>Tmden_1312 putative transcriptional regulator, Crp/Fnr family
MRIHLKNTLLFQNVDEDTIKKIESFTTDHKVSKDNIVFYEGDEPKYLYLL
VKGVIKLYKTSSSHKEIVLKYFHENELIGEVANFENIPYPATAKAYSDVE
FLKVDFEKLKEVIFLNPSLAFNIQTSLIKKIKNLENIISTNLVLDSKERV
AKYIYSHSDDFFETKNIEIAEILGVSPETLSRILKFFKDNGIINIKKKYI
DKETLSNYF
>Tmden_1653 methyl-accepting chemotaxis sensory transducer
MSNKTKNIIVTLAFGALIASLFLVDSTLVHVAIATLGFIVILVTNIKTLS
SSNTNLLNQKRLELIELMEFKRNKVKIDDTTTNEAEKNFNKIVTTYQASV
LEDTRVAGEMVLLTDKVAKGHYSCRIVSDSKTPYVHILRNSLNNMLNSSE
QNLDIAINTLQKFSQGLFATRSDIHVEAKMADLLNNINQLGQALQDMEAK
NSDSQKTIIESSKKLNDTISTITNSTIKDLKRMIGDAVNRIHNVAQKEDD
MVENLQTLVTNANETKTILATIGDIAEQTNLLALNAAIEAARAGEHGRGF
AVVADEVRKLAERTQKSLAETSATTNVLIQSISESSDALNRNAREVNDIS
SEVSLISNKMDEIIHTLSNLSK
>Tmden_1496 methyl-accepting chemotaxis sensory transducer
MFKNLSIHKKMNYFIAMVTVSVFSAAISIFIAMGYVDSQYEHLHENSMIG
GLTTLKIEKNLNYVSRLSRDIMLGGDYEKNLANLEKTLHNIEDGFNSLEI
LMAKDDSLNMVKEAKTSTMLFLNNTLKMMKSLDAQDIKDNKTQIYANYSE
ELTPFANTSRDSFKKLVEFKSKELEDASSSLAKVLNVFKYLALVAGIAVG
LIVLILATIIRKSITSGINNFTSLISYVAKGDFSHKGSENDRNTELGIMG
HELSKLIEHTQNLIHEINTTITDASKGIFSHKISSDGMSGEFVDAIESVE
KSIEFMKTQHAKAQRDVFNSKISTKSVNVSESLSLIISDLSSNINDLKTI
TSATKEASESAMNSKNDILNITRELNALTEQVNTNNHSILEITNQANEIT
SVIQLITDIADQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTHK
ATGEISVSIKSLQQDMNEIQTSSEMMKATVEDSTQKMNGFESALIELSNN
SLKMVDYSYGMENSIFIVLAKLEHILYKSRVYNSIVSLKKMFEQQDTHQC
ALGIWYDDEGKRRFAETSSFNKLSTPHEIVHKNANANLFYLDQRADEETL
KNSQNIINNFDNMEKASEELFALLDTMLQESK
>Tmden_0982 response regulator receiver sensor signal transduction histidine kinase
MYNILMVDDMEINLMLLEAIITTNFKHNIYKAKTVKDALEIVENSDIDIV
LSDIEMPLLSGYDFLRELKSKEKTKNIPFVFISSVEKSDTSQIKAYEAGA
IGFISKPINSKLLVSKLSSYFKIVDLCKEIKSTKTFVSLEKETRFSSMSE
MIHMIAHQWRQPLATLSSININVKAKKTLGVLSSQNIDESIEKVENIIDY
LNKTIDDFMDFLKDNEKKKNIFLGKLLSSPQKLLESYIDKSKCSIKIEYK
DGLNEFSELFLLESKLNQVLLNMIKNSIDEFISKDILNPLIKVTCGVDDI
NLYIEVADNGGGIEKSMMDRIFQPYFSTKNKNATGIGLYMSKLIITKLFY
GSISAKNIDEGASFKIAIPRDILKLNI
>Tmden_1270 diguanylate cyclase (GGDEF domain)
MYNATYFSVDYTIMQKSDLKALVEQIYENLLERIDGEEEASKEQVVSYLR
DAIDIVTNINDRDLDTIEHAKESFKNSYKEIVKESLNSYKNTNDKFGELT
KLNKDTIEKCNEQHIDLNALSEKFNDIHTHMSDEVRKANLVITELHQKVK
ILEETSNLDPLTKVFNRRSLSSYLQEVCSNKSLPYDDLHVMMLDIDNFKS
INDKYGHIAGDKILIFISNILRKTLRDGDKIFRYGGEEFTIVINRNSDDQ
CEQIANRLLHLISSNNLIYMGERISVTASIGVTKLKEHDTPDSLLSRADK
ALYVSKKSGKNMVSKDCN
>Tmden_0750 histidine kinase
MKSLLFLILFGSLIHANVFYIGDEKIDKASLFEVSTTYIDENSSKNIEDI
KKCEFQELKQNNFKAKKHRIWINFSLHNTSESEKEIYLENSKPGIDVVDV
YMYKDDVLLKIIELGDLRDKKDRELQTRKSAFILKLEPQSKYDFFVMHES
YGSISTIWSIQIRQYFEEMRSIENGVWGLVSGVIITLCLYNLMLFFATRE
LAFLSYVGMSLSLLVYQLNINGVLYQFLGNVNLQYLNNLSWFIGFLSLVF
SILFPLQFFKPSKKTFIFKYLVFMLFVYMSITLLYAFAFEYPELRYYTKY
TDIAAFMLIPSLIGTSIWALKKKLSGAIFYLFGQVVYLSALLYVFMITIG
YFKMFESIWLLLPIGITFDALFLLLALFAKLQEINKEKKENEELIISQAR
FTAMGQTIANMTHQWKTPISQLGSQIFLLEATHEIDKTNFATIWAQTLPK
MKESIVYLKDTINDIYNFYSSPLQKEKFSFKDEIESLLRILHDEITSNKI
SLIKDIDDLNYYSYRSSFLNVLMIILENSIYQLTHFKDKDRVIKISLKKL
EHKIKIDIEDNGGGLKQSDLKKLFDSYFSSKKGAGSGVGLVLAKKLLDER
LKGTIEAKKHSCRHSF
>Tmden_0749 two component transcriptional regulator, winged helix family
MEGIVLVEFKNFCVLYAEDDLEVQANISKILSLLFLKVHVASDGEEALEL
FKKNNIHIIITDYEMPRVDGYKFILKIREMSQTIPIVVLSSHTQKEKLMN
CIPLKLIEYLEKPIIYEKLLQTLKKCVKEIKNSADVEVMIGEDIFYNIES
NHIQKNAKTLKLTALEMRAFEYMFSKKNILVSNEELGFYVYDSHDYSVGA
IKNIIYRLRKKLGREFMQNHKDIGYILKSL
>Tmden_0006 GTP-binding protein TypA
MQKIRNIAVIAHVDHGKTTLVDGLLEQSGTYGAHEQHDERAMDSNALEKE
RGITILSKNTAIRYKDYKINIIDTPGHADFGGEVERVLKMVDGVLVLVDA
YEGVMPQTKFVVKKMLALGKKPIVVINKIDKPSADPERVVDEMFDLFAAM
DATEDQLDFPIIYAAARDGIAKLDMSHPDGNFECIFETILSQIPEPVGDK
ENSTQAQVFTLDYDNYVGKIGISRIFNGVIRKGDNIMLAKADGEMVKGKI
SKLIGFHGLNRMEIQEAEAGDIVAFAGLETVDVGDTICDSKNPMPLDPMH
IEEPTLTVVFSVNDSPLAGQEGKHVTSNKLKDRLEAEMTTNVAMKLEVVG
EGKFKVSGRGELQITILAENMRRENFEFGVSRPEVIVKEIEGIKCEPFEH
LVIDVPEEFSGAVIEKLGKRKAEMKSMIPMGQGFQRIEFEIPARALIGFR
GQFLTDTKGEGIMNHSFLEFRPYSGSVESRTYGALISMENGETLAYSLFN
IQDRGVLFIGPQTKVYEGMIVGEHSRSNDLVVNPIKGKAQSNVRSSGADE
AIKLIPFRDMSLERALEWIEDDELLEITPKSIRIRKKYLSENERKRYSRK
>Tmden_0827 response regulator receiver domain protein (CheY-like)
MITRNLNILSGYNVLYLEDDDSLLHQTKDMLSDFVKNVFAVKTSKEALEV
IKKERVDVIISDILLENENGIDFLRELKENQDIHIPTILTTAHTDTKYLL
DAIKLKVENYIVKPINLKELLNTLHDIVLPLTQEKEIQKNSNVIRTISAI
TDSKQVEVIKCILDDLNEQNEFIASYSDIMQKISISKPTLIKLFKELSEK
KILVKSAHKTYKFNESALDVI
>Tmden_0617 multi-sensor hybrid histidine kinase
MEKKIPNLVKNLDILKESKDIILKQWISYDSPQRILTLHDIDTKKFVNNY
ANGVFDYFMDVVAGTVHIGDCPIMREFIIYLKDKEIKAEELFDLCSHFRR
SMIDFTYDANINSKNIFEEISFMFDQNFQGILKYYTDTIYKKEQEIDRHV
KLLSEYQKALDESAIISKTDKNGKITYVNDKYVKISGYSAESLIGSYHSI
VKHQDMPDEYFKDLWFQLENMGIFRGTIKNNKKNGDYFYIDVTIVKITDP
YDNTTEYISIANDVTTLIDARLEAQKASQAKEYFLSNMSHEIRTPLNAIL
GFVNLLIDQDLSKQHRKYLEIILNSGENLLSIINDILDFSKLRSGEFTIE
PRIFSIHNEISHTLELFVASANLKEITITSFIDPVIPKELYADSLRIKQI
LSNFLSNAIKFTRVGGHIHVEATCKNRTLRVSVQDNGIGIAAGDISNIFT
AFTQAGGAEVEHMVGTGLGLSICNQLSKHMNGSVHVVSELGQGSTFWVQL
PVEIHDNSCQIFNDLEEIKKYKKVFYAKNMKHDYRSASFLQYSNIFGMDI
EVVDNTQCEHDLVIFLEEDVDKEFKDKIANSNKKYIALTNRPSDIYETYP
HVSTICFPLYCSKIKTAFDELIYPDETPQHRKEKGKKFRGHVLIAEDNEA
NQELIKILLIKYGLTYDLAANGLEAFNLYKANNYDLILMDEQMPIMDGNE
AIKAILAYEDENKLRHTPISALTANVIKGAKERGLSSGYDSFLGKPIVIK
ELERVFSNYLRSSKSVVLNKKTAVQNSSIKGLDLQKLTQELMLSESELLM
LATLFIKKMSKQIPEMQEAILTRDYQKMVLIAHSIKGSSGNFRLEEVQED
STEFEKMAKKEDSNYNYEEAFEKIKKRLLEIKIV
>Tmden_1941 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)
MKLKLKSKLLFLSVVPILFITFLSFMLLSDIIKNRQNLELTKQYILEAEV
ISKVIHFMQIERGTTTGMIANKKIDDKDTNLQHVKALCDRAVLDAKSTLD
VCDFCHNSQALGTLEDIKNRNNIKLLSLSIPDAKAYYTQQIESLLLFVKK
IPSLMNDKEHRNYLQAHSYLASAKEALGQIRATLMEVYSNKQLSEGSLLS
LIKFLEIYNLDCENFKTIASKDILAIHARHFRGEAVEKTLDMIHSIIRDR
NDINFSLVEPSYWFKQSTISINALRDVERELFESVTELINEKLKLTFYKI
LLITSFLLTTIITLASIMVLIVRKIISSTNSLEQNYDESISLLEQYRAAV
DRSFIVSKTDPKGIITYVNSEFCKISGFSKDELIGKSHNFIRHPQMKDNT
FKEMWHTIKELKKPWRGEVINLKKDGSYYWVKAIINPILDKNGEIVEYIA
IRSDITEIKNALTTDALTGYDNRTKLSEDIKELKDLSLAILNLDNFRQLN
DFYGHQFGNLVIISIANKIYNFISKDKKLKFYRLQGDEFVVVGVEYDKEK
FISKTKEILLLIKERFSMKNEEILLSCSCGISFEDNEHILSGANMALKTA
KKSSIDLLVYDDSLSLNQQYENNMIVTKKISDALKNDNIITYYQPIINNK
DENKEPKKYECLVRMRDGDKILSPYFFLDIAKQTKQYFGITKAVVFQAFE
MFKDKEAQFSINLSINDILDEEMSKYILMMLDRYEVGNRVIFEILESEYI
ENFEELLIFITKIKKYKCKIAIDDFGTGYSNFGYLIKLKPDLLKIDGSLI
RNIDKDKNARLIVSTIVEFSHKLGMKIVAEFVENKEIFEIVKTLGIDYSQ
GYYFSEPKESL
>Tmden_0796 response regulator receiver domain protein (CheY-like)
MQNFLSENYIEIVVFILFLGLSIIYLILRVKKNKQNKETTNIIREEIEKK
VDVKPMLSRKKRELIKHQKITRDDFSIFTGVKILIAEDNIINQKVIIGLL
STSGIDIKVANDGQETLDMLEINSDFSIIFMDVHMPILDGFQATKLIRKN
PKYEHIPIIALSGDTDAADIKNMLDVGMDAHVEKPLNIDALYDILYIYTT
AQESKNTILYKNNEALKEFDIALGLEICSGDKEFYIEILHDFISTYSNSA
MLIQELISNSNGSNAKKILLDISGVAANIGASKLHEIAIELKDSISNPAN
LEYITKLKKYKRSLQHTCKAINEYIKQN
>Tmden_1336 diguanylate cyclase (GGDEF domain)
MRKIKKLLYIYRSLSLLKKFLLAPALGLLLVLPFYIFAFFSMNNINNSVK
EFNKELNPLQETAYKNIFLLEKAVNDINSAIAAKEIEWIDSAEIHIEEIR
ENLHKFFQSSYQKDAQEAIKALDAYYKVARDVSQKIIETDNNYRNIESDT
KKVIENYKALDTSLKNIKLKIKQDIATSVNFIYESTTFLLLNGNLIFLVW
FILSTLIIVIVYRDIKYKINTIVKDSKEIASGDVDFEKRLCIVSYDELGQ
IIKSINVFINKLHKSHEELSEAKKELERLYITDQLTGVYNRVKIDEIIDI
ELKKQKRYGYVCSVIMIDIDLFKLVNDTYGHLAGDLTLKEFSALLKSNVR
DTDNVGRWGGEEFIIVSPQTDQDGALSLANHLRSKIEEFTFTTVGKKTAS
FGVASCSEDDDIQSLIDNADKALYRAKNSGRNKVVTHNA
>Tmden_0544 putative signal transduction protein
MTDEILKKIKQLPPLPESAMQIEAVYQDPDSTFNDMVKILEKDPLLTADI
LKAANSPLYGFSREINTINQAVGLFGMGTVRGFALASIVKKSFVLDLSPY
NIDGDMFSALSKKQHALVTSWCLRKEAKLLGILSPAAFLVEIGKVLIAQQ
IISSNSQEKFKEVLNSLGDVEAAEREVTGVDTPEVSATIFEHWRFETGLV
ETIRNCLNPENAKDDIKKAVQILQVARRAVQINGSITEESIASAKELILK
YNLDMESFEKALENI
>Tmden_1520 putative PAS/PAC sensor protein
MEYNESEFLIETKVPSDEVIISRTDLKGNITYANELFCEISGYTLEELLT
KSHNVVRHPDMPHSIYKDLWQTLKDEKQWVGVVKNLRKDRGFYWVKAIVS
GVYKDGELVEYKSLRAPISYGEKLQHQKLYDKIRKENGEKSRRVVYE
>Tmden_0258 two component transcriptional regulator, winged helix family
MRVLLLEDEFSLRISIKEFLEDIDYSVDDFADGLEAHDAIYAKSYDLLLL
DINVPSMSGFELLQSIRKDGIKIPAIFLTSMTELQGLKEGYRKGCCDYIR
KPFDLLELELRIKQAIRSYYLDNSDMVELGEGFVYDMLKGKLTKDDKEIV
LRKIEKDLLEMLIKNKNSVVSMQMFQDEVWGDYVEPSAIRVQINNLKQKL
SETIIHNRRGLGYIIER
>Tmden_0218 diguanylate cyclase (GGDEF domain)
MMIDGYIPTILIVDDKATNIAILSDLLKDDYKIKVANSGQRALSLVREKE
KPDLILLDIEMPQMSGYDVCKALKSSAETIDIPIIFVTAKNSSEDEEYGL
NLGAIDYIKKPFHSGIIKIRIKNHLTLKLKSKKLEELSMCDSLTGISNRR
YFDEILEQKYREIIREPKNLSIIMIDIDYFKLYNDNYGHWMGDECLTKVA
IALKKAIKRPTDVLARYGGEEFVVLLKGVDKDGAKQVAQSLIDSISNLNL
AHNFSPVSKIVTISAGVAIKEVDEDISKEDLIKKADAELYRAKNSGRNKF
CAGF
>Tmden_0826 histidine kinase
MKIRKILLAIEKISFSYKTSILMFIIIGGMISIIVLSQISIYTIKNDFDV
LFEKRTKPILKLEAIKDAYLINIQESILDVHNQNIDLEDSYDVIILGEQI
IKDNWAKYLKINFSDEYEVSFITKTIKKLFTIGNQNQNKILQRSIISNIS
EKIKRMDILVSEILVELKNPQSQNIKTLIQKVNFEVNAISIYLTNLTNYD
LNMAISEKRDTQNIFNTLSMILNISIIFVFVFSIVLSVMIIIHFRKLHFR
LKDAVNEKTKELLKLNQSLERRIANEVANSRKKDLIMFQQARLASLGEMI
ANIAHQWRQPLASLMMIIQGFETKMELGKLTPEILKQKVDDATLLGENMS
KTIEDFQNFFKPSRDKEMFSLKRCIEHSFELSKYLLEKEKIEFFLNIKDD
EQIYGFYNELSHVFLNIISNSKDALSDKEYKRLIEVVVKKSKNKIRVNIV
DNGGGIDEDILPHIFEPYYTTKYKSSGTGIGLYMSQQIVEKQMNGKIECK
NIYYKIQDENFQKCTIFSITIPLKDENDN
>Tmden_1559 two component transcriptional regulator, winged helix family
MSAKIVVVEDEEDILELIEYNLAKEGYEVIGFLNTKNLQQLLYEERIDLL
LMDRNLPNVEGSEFISLLREKGFTTPVIYLSAKSLDSEIEEGFLRGGDDY
ITKPFNMRELLLRIKALLRRTTRNVEDTILSHRDLVLENRERTLKIDGKN
VDITKLEFELLSEFIFNKNIVLDREYLLEHVWDGAEDYQYQTVNVAINRL
KEKIDPDKTKEYIQAVRGVGYKLC
>Tmden_0528 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)
MINNHNDDSFAFYGINSDSIVDQSNIDIETIKSLIRNLNEAQEIAQIGHW
KLNINTNELFWSDETYRIFGLKPKEVKPSYENFFTFVHEDDRSLVNDAYI
KSLEDKSPYSIIHRIITKDKKLKYVEERCVHKLDESGNVVKSIGTVHDIT
ERVEHEKELEIASNVFKYSSDGIVITDKNNNIVSVNKSFEKLTGYSKEEI
IGKNPKLLSSGWGDEEFYKNMWSSLLSNDLWRDELWDRKKDGSLYAIEQT
IICVRDKNQDIVNYIGMSRDITEAKNKEEKIHQLAFYDFLTKLPNAKLFQ
QEVEAYIKSTHYNNETFAILFLDLDNFKWVNDSLGHQIGDLLLIEIAAKL
KEIISQDSIISRLGGDEFVILAPYENLLTISQLANTILCSVKDPIKVQNR
EVNVSWSIGISLYPQNGENYNDLLKNADAAMYESKNRGKNTFRYFNDMMN
QDAMYRLELDTKLRYAITNNSFFLNYQPKYSFEHGKTIGVEALIRWIDKD
LGFIAPDKFIPIAEESSYINEIGSWVMKQALNDLKIINSKLSSPISISIN
VSGKQLEHESFYDEARTLLKESGIEPSLVEFEITETSIMQNIDHVVDILK
KIKMLGVKISIDDFGTGYSSMSYLKKLPIDTLKIDREFIKELEIDEDSKS
IVNAIIALAKSFKLTTVAEGVENEEQKLILDGLNCDMTQGYLYSRPLSLD
DLLAFLS
>Tmden_1759 two component transcriptional regulator, winged helix family
MKKILMIEDDLELAEILTEYLQQFGFDVVTEDDPFKAVSILKLEPFDLVI
LDLTLPGMDGLEVCEAIRERQDIPIIISSARSDVTDKVKALELGADDYIP
KPYDPRELEARIHSVLRRYEAKSQQKEESKSDFKCDMSSMMITYRGRNID
LTNAEFGILSYMIAKQGLVVSREDLIHNVNAINEDSSNKSIDVMVGRIRN
KLGDKSLIESVRGVGYKLLK
>Tmden_1932 methyl-accepting chemotaxis sensory transducer
MKKMSIKMQVILLVIASLAVLALISTSIASSKSKEALLSENLSQLSKGRD
LKKGQIEDFFQSRVKDIEVLSRSKDLAELASSLIRVHNELEVKGEDDYPA
KNQMALAEIAPHETYFQAYMKDYGYSDIFVVCAKHGHVMYTGAKKSDNGA
NLTHGSLKDSSLGMAYKEALKNNRPTFIDMKPYAPSNNEPSMFLSTPVKV
NGEVKAVLIFQISNSAISKVMSYREEGSAATQDDYLVGADKLMRSDSFLR
KDTHSVKASFANPSTGSGDTQASRNALEGKTGNVTSTGFDGSSVIFSYSS
IQIGEDLKWAIISRIGEEEVIASANEIRNTLIIDSLLLLVVIIIISIYVI
NVSLVKPIERFKTSLLTIGDNKNLTIKVDENAPLELSQMAHSFNTLILTL
RDLIETSKQSASENASISHELSTTAMGVGESVEKSVSIIDDATKKANSIK
DEISQAIHDAQESKKGILQANENLDMARAEIVSLSKKVGESAQLEVELSD
RMQTLSHEANEVKNVLEIISDIADQTNLLALNAAIEAARAGEHGRGFAVV
ADEVRKLAERTQRSLTEINATINVIVQSIVDVSGQMSSNSEEVQALAQSA
SDVEDKINNSVAIVENAVRASDKTVSDFEKTGKNVEYIVSQVTQINEISS
KNARNVEEIAAAAEHLNSMTDELHGKLEEFRT
>Tmden_0616 two component transcriptional regulator, winged helix family
MEKHTIIIVEDDEITALNLKLSLQKQDYKILAICDNAADAIEKIKEHKPH
IIIIDISLQEGSDGITLGRKIRQNYSIPFIYLTSYSDDDIITEAIKTEPY
GYIVKPFDPSSLHATIQMAVFKYEMECKRFEEMSASKIDEKSVEKLLYSK
SELDSGTVLFGSLYSIDIAKKEIFYNNQKLKLTKKESAILLLLVAKLGNV
INFDQAINYVWKESGATENSIRTLVWRLRSKLPTDIIKNASGIGYYIEK
>Tmden_0220 diguanylate cyclase (GGDEF domain)
MIKFNKYALIGTIFILSLFSSFYFIDVFSEKNMELQKQILIKQAQTHFKD
QVNTRVWNASYGGVYAIPKEGQKPNPYLRDNILKVDENLTLIKINPAWMS
RQLSEISNIDGFHFRITSLKLINPDNKATPFEERALKYFDETNEKEYYEI
DKESNFNYMGALITTEYCLPCHKHQGYSLGDVRGGISVSLDSKEYFEVTS
SIKTSIILLKIFVVIFLFTIFSLIFKQLRYNQQLQTEVKRRTKEIESTKH
LLQEIIDTDSSFIVLTDDKEIIYANETILNFTGYHSIEEFKKNNEYIFDV
FEKIEDNSNFMQTCNDGIHWIEYLIKEQNSKNLKVCIKKDGKYRYFKPYA
KEIKTDDKVLYLITFDEITNEYVKIKELEHMASTDALTKLFNRTKLNDVL
EKEMALSRTVPSPLSVIFLDIDYFKAVNDTYGHDAGDRVLINIANIITSS
IRAGDIAARWGGEEFMIILQATPVSEASVLGEKLRARVEGHLFETVGKIT
ISLGVTEYINAESEESFIKRVDEALYEAKERGRNKIIIK
>Tmden_0978 response regulator receiver (CheY-like) modulated CheB methylesterase
MAIRVLIVDDSATARTVLKDVLSKDSEIEVIATAPDAYVARDKIVQLKPD
VICLDVEMPRMDGISFLKKIMKYFPTPVLMVSSLTQDGAQVTFDALEAGA
IDYVAKPHSNIYDGIDEIQKELIQKVKMVASSNLSARIEAAKAKTSTLEY
KPKATYSLAQTTNKLIAIGASTGGTVALAELIARFTKDTPGVVVVQHMPS
GFTNSFAQRLNSLCEVEVKEAEDGDIIGRGRVLVAPGDLHMVVRRDGGNY
RVKLGTGEKISGHRPSVDVLFNSVASHVGSNAIGVLLTGMGSDGAKGMLK
MKTSGASTIAQDEKSSIVWGMPKVAYEIGAVDFVEPLSNIDVKIASLLSE
RK
>Tmden_0886 metal dependent phosphohydrolase
MKIIKTKLDYSHSYIQFDINTISVDQIVPFDIYIKKDNDYVIIIEAGTYI
SETLWSKLKNHEALYISTSDEDKQILSCKSLRYYIRHNRENHQKRVALLY
DVTSKLFNVFIKSQDNKIDPDCTELIIKSIIFLIKYDEYFIKNTMTYLRD
EDLLEYHSLHVAIYSLALGHALKYSEIQLIKLGVAALLHDIGLKKIDTNI
ITKEAKLSAQESQAVQKHCNYSVEIIKQNKILDPYIIDAIMHHHERYDGT
GYPNQLTKENISDFAAIIGICDVFDALTSHRPHRKSLSSFEALKLMMKDS
EMINQFNQKYLLISLKMLSKGHT
>Tmden_1925 response regulator receiver domain protein (CheY-like)
MKFLLVEDEEFNLIVLEEMIKISYPDAKIVLTNNGQEAYEMLQTNSFDLI
LSDINMPIMDGYALIKKIKNELLLTTPTVAVTAFAIQGDKEKLLMSGFDY
YISKPIDMAELHKVLKVSLLD
>Tmden_0664 two component transcriptional regulator, winged helix family
MISPKYSLIGHKFMRILIIEDEVTLNKMLAEGLKEFGYQSDVVETLKDGE
YYLDIRNYDLVLMDWMLPDGNSIDIIGDIKTKTPKTVVVVLSARDDNESE
IEALKSGADDYIRKPFDFDVLVARLEARLRFGGSNIIEIQDLIINPEEEK
ITYKEVEIELKGKPFEVLTHLARHRDQIVSKEQLLDAIWEEPELVTPNVI
EVAINQIRQKMDKPLGITTIETVRRRGYRFCFPKEIN
>Tmden_0613 diguanylate cyclase (GGDEF domain)
MSKYNFYKFFTLYFILFGIAISVLGSFVSYALQVKDINFDMAKKANEIFE
IKTDSILKPFIENMDNTVISLVSNNTIKEFLKTRDEHAKNELEQIFLAVS
SSQSIITQARLICKDGKELIRVEKDNNNDTNIIVEKSKLQDKSDTYYFQK
VSQMKEERLWHSKIDLNIEHGKIEIPYKPTIRLAMPIITNGEFSGMVIVN
VLVENLFLAIGKSSAFEHYIVDKENNYILHANDKFSFNKYKNIKRSLNED
FENGLEAKGVYTFALDNILKNEDKATLVFKTKKSYENSLFKKELNTIIII
LIANIILSFIVAIYISKTPTNLQAALVKAHEKLNEFASIVDKYVITATTK
PDSTILSVSSAFESSSGYTKSELIGKKMNIINNPQQDKKIFLELWSTILK
GEVWSGIMKNRTKKGDIYWLEQNVVPTLDKDKKIESFVSVGVDITAKVEL
ERLASIDKLTGAYNRRMIDEFMKKEIFLHVRDSKNLSLIMADIDHFKLVN
DTYGHQAGDAVLSDVGRIISSTIRKSDIFGRYGGEEFIVICPNTSSQQAL
ILAQKIREEIENFHFAEVGHKTISLGVATLIANDEVENIIKRADDALYIA
KKEGRNRVVLG
>Tmden_0930 metal dependent phosphohydrolase
MDTIKVLGAQGGRSKDSFTTSIMVTKNTVIDAGNIMQALDRDAKNINKIF
FSHSHLDHIVDSAFLIDNSFATREEPLYLYGLPQTIKALKKHLFNSEIWP
DFSEINLINTKTPSVVYVELELYKKYELEEGVSLTPLEANHTVECCGYLI
EGKKGSILFSGDTFKNPKLWDIINSNESIKALIIDVSFPNKLTKIAQHSK
HLTPHFLREELELLKRKDVKIYINHLKPFYHEEIIEELFEIGISRDRVLN
DSEEICFKNGLIKRVSMQYTTEQKIQKLNKIGTALSAETNIDALLEIIVT
EAKILSNADAGTLYILEDKHLHFKVAQTDSLGIKMGGISGAITWPPLPLY
LQDSTPNNKMVAATCALSDIVINIPDVYEAEGFSFDGTRKFDEGTGYRSK
SMLVIPLKNHESEIIGVLQLLNKYDDNNETIAFDKEDEELTLSLASQAAI
AITNTTLIQGLETLLEAFLQSIIFAIGKKSPYTAGHIERMVKLTVMIAEA
IDKDKGVFSAKSFSAQELKQINFAALMHDIGKLATPEQVVDKSTKLETIF
DRIEVVKGRIEIIKKALEIELLNQKITLLQSGKTLHVELESEFSKKTDLL
DSYFEVIQKSNRGTEFTNDEQIAIIQNIASQNWEIDGKSYLILTENEAYN
LSVQKGTLTSQERAIINEHAKISIDILNKLPFPKKYKEIPQISGNHHEKI
NGKGYPLGLSGDEISFEARILAVADVFEALTASDRPYKKGNPLSSAMKIL
YFMAKDDDLDRDIVKFFYNSGLYLQYAKKLLPKESIDEVTTDFSSL
>Tmden_0986 multi-sensor signal transduction histidine kinase
MRDYERLKSITILYVEDSKFLSKMTAYSIRDYFNKIYIAHDGQEGLRLLR
EHNAEIDIVVTDLIMPILDGKQMIKQIREGGCSVPIIVTTGYDEYMEREK
MLEFSIGAFLSKPIDKHKLLDSIDDTIDALFIKRELATKKAMIDNDIIYS
ESDKNGIIRYVSKPFERISGYSKEELLGNTHAILKSKETSESTYKEMWKN
LSSYKQWQGEITNRKKDGSLYSVNMIISPMYFRNKLIGYSATSLDTTELK
RTSAELQAKSKHAALGEMIAMIAHQWRQPITSIGMIANNLQFDMLMDELD
INVLEENLKIIDSHVKHLSSTIDVFKNFLQESKTKESIVMQNIIKEALLV
LREDARDTKIKYDVDEKCASIEFDTFKDELVQAIINIIINSKDALIQNNI
EEPKIKIICAKDSDFITISISDNGGGIDDDVLPKIFTPYFSTKNEKNGTG
LGLYMTKTIVEENLDGELSVSNIDNGAIFTIKLPYKS
>Tmden_2035 diguanylate cyclase (GGDEF domain)
MAGPLRSRINRNNTTAKPLAAVTDKSVAVEPEGELELYSKEVLNALIKDG
LPPTPNNFALYFDRLLEDKSQSARAHIASMLELEESNDAENSIMIEQSLK
QGFSYIKNILSITANLYKNMALMTKILEKRKEDLEASGDIKEAKNIATSL
GFDIIKLNEIIKKQSSSIKCMYDDTAKIIKNVENETIFDNQYGVYNKRYL
MSKIEQEISLIMKFKHKSSLIMIELSRDLKASVANEKAVMLMTKTIARLL
LKTSRRSDIVTHYGNGVFVMLLKHTDIESAKKASERLCELVSNSNFFLAD
REIQLKISVGITDITEDSSVEEIIVSSMDGIEKAYENPKLDYAVLLRKT
>Tmden_1558 histidine kinase
MLKIHQIFIIKFLLLLAGTLFITSLISYLALKSSIIEHNKNHLKHAIEIL
DIELSKIDNLDKYVSDIHKKTSLRATIIDDKGAVLAESNANRTDMDNHAQ
RFEIIQSSTKEYAYTIRYSNTVGADFLYVAKKIVYKNREVYIRLSMSLAQ
IMEDFYSLWIKLLFVFLSILVIALFVSRKMSKKVVYDIEQITNYLDEISN
KNYKAIIKTKYFYEFLQISLLLKNLVKKLSKNEKKKSKYMAKLRLINRQK
NDILSAISHEFKNPIASIMGYAQTIQDDNNMSKSVRDKFLDKISSNGEKI
SKMLDRLTLSVKLENEELEIHKSEFNLKILCDEVASSLELKYKDRQISLH
VDSLTLFSDKTMLELVVVNLVDNALKYSSSDVLIEFKDGKLLVKDSGVGI
KEDELQNVTKKFYRVDKNSWNNSMGLGLTMVDYVLKFLGSSLEIESKFGH
GSTFGFSVEKMLKS
>Tmden_0719 metal dependent phosphohydrolase
MSQVDIGQIKKIDTVDLAIKYLFAQIPPSQALQKALDYSTLAHVNQFRKS
GEPYIIHPILVASIVSSITNDESMAIAALLHDVVEDTEVDIEEIKDVFGA
DVAHLVEGLTKIDSIRDTELVSSNSNEKLVVSALSFRKMLLASIKDVRVL
VVKLCDRLHNMLTLESLSAQKQQRIAEETLVVYAPIAHRLGISFLKNLLE
DLSFSTLFKEEKEQIDSYLEVHYHAIEMKLIEFKEAIEKVLVQNGFCEDD
FEILSRVKHKYSIYLKMQRKGVGIEEILDLLALRILTKDPVKCYSILGLI
HLHFQPLSSRFKDYIAVPKDNGYRTIHTTVFYKTAIFEVQIRTYEMHETA
ELGVAAHWKYKSGGNDAIKLDWLHNLGYQNESIEEFYDLIKNDLYSEDIS
VFSPKGEVFTLPRGAVVLDFAYAIHTHVGNHAKSALVNKAKTSLINELHN
GDIVKIDVDENIITRCSWLDAVKTSKAKTNMRYNCNARVRDVDSKSSINI
VATAMNLNSSVIEAWFEKNSCDKRATIATDIEHLRDVVQRYIAEIEKNSR
IKGFLSRRRFKLKPYSFRGLEIYSTSNINDVVFDYCCHPKNGDEIMAFLE
KNKAHVHHKMCSSATKKLDEKEAMVFVRWEKLNIYNYNMIVSLHSGVGTL
AEFLNFLAKLKIDINQIELGKNKSESTRYCEIGFESKEADINALRAKIEQ
KIKVIHFIRTDDAYR
>Tmden_0969 response regulator receiver domain protein (CheY-like)
MNIFKELKEFAKELTLLIVEDDTALNAELYELSKLFFLDVKTAYDGAKAL
EIYKKGSIDIVLSDITMPVMNGVELCKKIKVLNQDQAIIVLSAHNEVEYF
VELIDIGIRQFIHKPFKDEEFLYRLLKVCENVFLNKFYKENEEHVVSQKS
QHVAIEAESKTIDKILAPKQLSSKKFLTDLQNNSSLWSVIEEDIVTLIEI
NDDFEIYINYIFEGNLSSGLLLKISELLKKMQTILSQIDFMRQMAGLILD
LSTFLKEIDLDSLDSEQKNKFKMVEFIYDDISRFIQTVFVYKDTIDVFYL
QDSLKSSIEQFKKSILNSPIQEEEFELF
>Tmden_1626 hypothetical protein
MKDDDFILEEDSNMPQEGDLIFDKDNEKLEEPKKPPKKYTPNKGSTSPPV
GESIVNTQSLQELLSELSFISIQIQKDTDELKKFEGMGKVISNLESIKNK
EINIDVAPLISKIESEINLISQDLKTKAAQIKNDFDFSELDEIKKSLQDV
NNNVKKAKSHQIFWVALFAFGMGMSAPYVAPYLNVTLPFLGEVAKKEIKI
VEKQVIVEKPIYVEKPFYVEKEVKEPCVNTNNLGIFDNPNGDKSLIYLKN
LGEVTQKKDGIYYIPLKAIAKNPKN
>Tmden_1035 CheC, inhibitor of MCP methylation
MNLQFNEDQLDALREFMNVSIGAATASMANLLNAFGTMHIPKIEVCNSDE
LAVKIQESIDIRSMYFVTKQLFTGKFGGECMFVISEDSSINLGRHLYSIE
NPSFDDINDAVIELTNILTSTIVSRLTQELNTQVQFFVPSLQFLDPSSIV
DEEDVAEYSKIIIISTILDFQDQQIIGNIYILTKDEAIESLKVLIDKKIE
EIYG
>Tmden_0209 methyl-accepting chemotaxis sensory transducer
MSIKYKLNLITAIVVSFALIIIAIATLKAIDDKENISKSQSLNTLSQKLS
LLIHETQKERGASAGFIGSHGKQFGDILPNQRASTTKEYESLKVYIQSLD
LDFFPKELKDEISAFNEKMSQIEQIRSKVTELSIGSKEVVTYYTEMNSKI
LNITSLSAKLANSAELVKALSAYNNFLKSKERAGVERAVLSSTFAADKFS
DGAFAKWITLVAEQDAFLDSFLSMATQSSKDLYKQKINSPVIAEVNKMRE
IAKLRANEGSLGVDSVIWFSTITKKIDILKEIDDELAKQNTLLLEELKAA
SIQKATISIGSYLAFAIAIFIIIFIISRGVNRSVRSSLEKIDCVSSNLDL
TCDIIVEGNDEISRISKALNVMIIAFKESVYQAKDVSATTSSESKVLNSI
VEQLTKNGIVADKKITVINTLVTEVGQRLDAIEESSITVTEDLNITYSVL
DTFVNQLHLVVEAIEHGSNRQQELVQKVYSLTEQAKNIKDVLAIISDIAD
QTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQKSLSEISANVNL
ITQNVIEISEETQVTSENMGNIANSAQELISSSEQTKENLSVTNAKSSDV
MYQSTYIATKTKELIHNMDEIIELSKKNTEHRNLVDEAATKLLSDANRLQ
NELSKFKI