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# Streptococcus pyogenes phage 5005.3

>M5005_Spy1401 PTS system, galactose-specific IIA component
MFPNILFTEARTQPELFDLVASHLEKVGYVTQEYHQALVEREAVFPTGLK
VDLKDGSDILYAAIPHTETKYCLVDQVVYVRNSQALTFKHMINPEEDCLV
TDFFFIINSQNEGQTTILSNLITFFITKGNLSYLASLKDDKQAISNYLIE
KGVFQHD
>M5005_Spy0483 stress-responsive transcriptional regulator
METKFYKQRKNRLVAGVIAGLADKYGWDLALARVLAALLIYGTGFGVLLY
ILLAIFLPYKEDLLEERYGRGPRRRKDADVLNEEEDGWFW
>M5005_Spy1173 phage protein
MATELIFGVGGFILAIVTTYNIFNAKSIKHATDITLLQSEVEHLKIVTRQ
NARRLEEHAEQNKTLITMTEQIKNLTDDVKDLKDMMRGEIK
>M5005_Spy0982 histidine-binding protein
MIIKKRTVAILAIASSFFLVACQATKSLKSGDAWGVYQKQKSITVGFDNT
FVPMGYKDESGRCKGFDIDLAKEVFHQYGLKVNFQAINWDMKEAELNNGK
IDVIWNGYSITKERQDKVAFTDSYMRNEQIIVVKKRSDIKTISDMKHKVL
GAQSASSGYDSLLRTPKLLKDFIKNKDANQYETFTQAFIDLKSDRIDGIL
IDKVYANYYLAKEGQLENYRMIPTTFENEAFSVGLRKEDKTLQAKINRAF
RVLYQNGKFQAISEKWFGDDVATANIKS
>M5005_Spy1021 phage protein
MAKTPQQYWNERQKQLWANLETSERALQTKLSKYYADEAKSLEKEIGAYF
SKYGKDNVIEYRNLLQQLSKADKDLLYRDCERFAKKYPQRADLMPVRTSI
YKLDRLQGLELSIKIQQLEIGAIEEAELTKHLTTAFKKGYQETAKTIGFQ
ADKVSAELFVNNDWTGKGDFSSSIWSNKDKLVDYLTNDFKTAIIRGDSFD
KVVKQMSERFTVRSQSDITRLIMTEGTYVNNQAMMAPFEDSDDFEEYEFV
SVLDSSTSSICRGLDGHKFKLKDRQVGVNFPPMHANCRSTFAMVIPDDYL
ER
>M5005_Spy1418 phage protein
MHFDLLQAGAAAAALMSVFGLWKAVVTPFKKAMEANEFAMAQLKDSLKEL
AYELKNLDRDREITKKIIDRHEERLGRVEDEVIINKERIITLFKKGEEK
>M5005_Spy0999 phage protein
MSTFLTNINLNKNELQNAVVQNLAKEPHEPKSGQFYFDSAANNLKIYNGT
SWVVLDKETAESIVDLINSGKSKIDKSKVDGLEEAINQASMTGQAIATAL
NEDTGGVTVNQNKITGLTDKLAEIATNKASATRESQDALQEAKVYADQKV
AGLVDSASEDYNTFKELETFIKQNAKGLAAISNVAKKFSKTFGDARAKEF
TITHNLKTRDVNVTIRETNFPYAIVYADIKVTDENSILIATGAEVLTQNQ
YTVTITG
>M5005_Spy0236 ABC transporter amino acid-binding protein/amino acid ABC transporter permease protein
MKKLILSCLVALALLFGGMSRAQANQYLRVGMEAAYAPFNWTQDDASNGA
VPIEGTSQYANGYDVQVAKKVAKAMNKELLVVKTSWTGLIPALTSGKIDM
IAAGMSPTKERRNEISFSNSYYTSQPVLVVTANGKYADATSLKDFSGAKV
TAQQGVWHVNLLTQLKGAKLQTPMGDFSQMRQALTSGVIDAYISERPEAM
TAEAADSRLKMITLKKGFAVAESDAAIAVGMKKNDDRMATVNQVLEGFSQ
TDRMALMDDMVTKQPVEKKAEDAKASFLGQMWAIFKGNWKQFLRGTGMTL
LISMVGTITGLFIGLLIGIFRTAPKAKHKVAALGQKLFGWLLTIYIEIFR
GTPMIVQSMVIYYGTAQAFGISIDRTLAAIFIVSINTGAYMSEIVRGGIF
AVDKGQFEAATALGFTHGQTMRKIVLPQVVRNILPATGNEFVINIKDTSV
LNVISVVELYFSGNTVATQTYQYFQTFTIIAIIYFVLTFTVTRILRYIER
RFDADTYTTGANQMQIAEVSNV
>M5005_Spy0706 cystine-binding protein
MKKSVTLLSIGLASLLLAACAPHQSQKSSWDTIKEKGVLKVATPGTYQPT
SFYNDNNELVGYEVDMVKEIGKRLNIKVKFVETGFDQAFTSVDSGRVDIS
LNNFDITPKRQKKYNISTPYKYGVGGMIVRADGSSNMAKKDLSDWKGKKA
AGASGTEYMKVAQKQGAELVTYDNVTGDVYLNDVANGRTDFIPNDYPAQK
LFVDYMLSQNPNLNVKMSDVQYNPTEQGIVMNKKDDSLKKKIDAVIKDMI
KDGSLKKISETYHAGQDLTKPFGKDKKIPVIDTKDVN
>M5005_Spy0446 hypothetical membrane associated protein
MSMMDKTVLYFGLVEISFDVPDFIFQKIKEQNNKIRYYSKSINILGSVKF
INSNQQFIEYDGNGNILVYGRLKYFKEGISLYYIGEYLAECLLIEHSDTL
LIHAAAVYNPLSGHSILLLGDKGAGKTTVAIRLCIEHGYHLIGNDQVIFG
SNSGILLTYAGTSFFKIRRTAVLSDNLLFKLFSKFFNRSLQFNKASWDDK
ISIFPKELGIRTCNFSTEISKIYYIKTDKKEKQIYHSIWSDSLASLYLNE
LLGRHISGQVACFQSDNGKYFSTMPLINYEKNNRVREQIVKGIFAKQKLF
KITAATPAKIAEAIIENVKKNS
>M5005_Spy0036 protein tyrosine phosphatase
MKKVCFVCLGNICRSPMAEFVMKSIVSSDVMMIESRATSDWEHGNPIHSG
TQSILKTYQINYDITKCSKQITITDFNTFDYIIGMDSDNVKNLKEMSQHQ
WDSKIYLFREGGVPDPWYTNDFEETYQLVRKGCQDWLSRLMSKEY
>M5005_Spy1295 hypothetical cytosolic protein
MAKQKNRKKALKLEMKRNGLLKKAGQVFDKAVESVETAVDKTISAGKNLV
EKGSQTVENLTASKERLTLDEFAGQPVVAGIRSDLVETLYAEGIHSAQAF
KEWTEKDLLALKGIGPATVKKLVENGASFKK
>M5005_Spy1281 two-component response regulator
MYSLLIVEDEYLVRQGIRSLVDFSQFKIDRVNEAENGQLAWDLFQKEPYD
IVLTDINMPKLNGIQLAELIKQESPQTHLVFLTGYDDFNYALSALKLGAD
DYLLKPFSKADVEDMLGKLRKKLELSKKTETIQELVEQPQKEVSAIAMAI
HERLADSDLTLKSLAQQLGFSPNYLSVLIKKELGMPFQDYLVQERLKKAK
LLLLTSNLKIYEIAEQVGFEDMNYFSQRFKQLVGVTPSQYKKGGQA
>M5005_Spy0784 two-component sensor kinase
MRGEQVEEHFKKQLQDDISRHFSYQSLMLSLLLIGLFIIFSLAPQQLGLY
RDINATATRYHRLISKQEALLDDLGKNSLLPFLNKNLSTADLSKHYFHLR
HSSQTSPELLLFSPSQDLLFASNPHLGNVFSKSVYIQEVLRATHPPKTLF
KVAMDSEDGHYLMIIKPMIDQNQLKGYAFLVMSGKDFLHPTKTLTSELVI
ADKLDNTFTFSNREFIASSLDKINSQYLHHYFVFQDNRAFITRKVALQGG
LWLYMYRPLIPMVSVMLFSLISSAVIFVILQRKSSGLANRIAAKNSRAIN
QMVRDMSAISRQEKRRIDLESQDEFQYLSDQINQMVERLQQLHDKTLDLE
TQKLLFEKRMLEAQFNPHFLYNTLETILITSHYDSALTEKIVIQLTKLLR
YSLTDSSKPVLLKDDLSVIESYLVINQVRFEELQYSINLSPDLDSLEVPK
LFLLPLIENAIKYGLKERHDVKINIACYYQDDHIIFSVRDNGSGIDAHHQ
KVIREQLEAGESHHGLINSYRRLKYHFSEVSLVFDQGDKQFNVSYHVKE
>M5005_Spy1306 two-component sensor kinase
MSVKTLGRYVTNHFKQGFLINRLMKLYSLLIVSFFTLAAIGLSSYSISST
YKRVDAEAQMRLEETLGRLQSQNDITLRVLDQLVGRSEDYHNLYQYMTLT
PNQYFSNVFEDWEKGKDTVLFSEEVRRLFDLYPDVTSMTLLLEDSSAYLY
ADKVIKTGRLLYSKPEKVTGNVLVRSIRNPESGDVTGRLYLTFDKPPTLV
ETQQDHYLATFAFDYYGRKLFHQGGRRFPHLEAEVKKAIKADRAADLSNL
SKAYRMQYNRSGDLLAYVAVRKSYLLAEAVRTVFVYGLVSLLLAWLLLQL
LFRVFRNYIQQVSEITDTVEMVAAGDLSLTIDNSHMELELYHISEAINQM
LASIKAYIDEVYVLEVEQRDAQMRALQSQINPHFLYNTLEYIRMYALSCQ
QEELADVIYAFASLLRNNISQDKMTTLKEELAFCEKYIYLYQMRYPDSFA
YHVKIDESVADLAIPKFVIQPLVENYFVHGIDYSRHDNALSIKALDETDY
LLIQVLDNGRGISQERLADMEKRLQEHQTTGNSSIGLQNVYLRLFHHFRD
RVSWSMAKEPNGGFIIQIRIRKDA
>M5005_Spy0150 PTS system, 3-keto-L-gulonate specific IIA component
MNLKQAFIDNNSIRLGLSADTWQEAVQLAVQPLIDSKAVTSAYYDAIIAS
TEKYGPYYVLMPGMAMPHAEAGLGVNRNAFALVTLTKPVTFSDGKEVSVL
LTLAATDPSIHTTVAIPQIVALFELDNAIERLVACQSPKEVLEMVEESKD
SPYLEGMDLNA
>M5005_Spy1514 universal stress protein family
MSLKYKRILVAIDGSYESELAFNKGVNVVLRNDATLLLVHVIDTRALQSV
ATFDTYIYEKLEQEAKDVLDNFEKQAQIAGITNIKQIIEFGNPKNLLAHD
IPDRENADLIMVGATGLNTFERLLIGSSSEYIMRHAKIDLLVVRDSTKTL
>M5005_Spy1280 two-component sensor kinase
MKRYPLLVQLISYVFVIVIALITTLGLLYYQTSSRNIRQLIERDTRQSIR
QSSQFIDAYIKPLKETTSVLAKNTEIQAFASQIHQENDKQVLQLMKMVLA
TNSDLQAAVLVTKDGRTVSTNSQLTMKTSSDMMAEPWYKAAIDRQAMPIL
TPARQLSLSSKKEWVVSVTQEVVDRAGHNLGVLRLDIAYPTIKASLDQLQ
LGRQGFAFIVNDKHEFVYHPKKSVYSSSKEMAAMKPYLAIQNGYTKDKTS
FVYQKLIPNSQWTLVGVASLDQLHRVQRQIFWSFLGTGLLACLICGFATV
LVLRRWIRPIQQLQQVILAIQKGDRQLRAQETGSPELTDLAQQFNALLDQ
IDSLMVAVADKEKAIGQYRLQALASQINPHFLYNTLDTIIWMAEFNDSKR
VVEVTKSLAKYFRLALNQGNEYIRLADELDHVSQYLFIQKQRYGDKLSYE
VQGLDVYADFVIPKLILQPLVENAIYHGIKEVDRKGMIKVTVSDTAQHLM
LTVWDNGKGIEDSSLTNSQSLLARGGVGLKNVDQRLKLHYGEGYHMTIHS
QSDQFTEIQLSLPKMHELMADDTQENE
>M5005_Spy1837 phosphoesterase, DHH family protein
MKKFRFETIHLIMMGLILFGLLALCVSIMQSKILILLAIFLVLLFVVALL
WYQKEAYQLSDLAHIELLNEQTEDNLKTLLDNMPVGVVQFDQETNAVEWY
NPYAELIFTTEEGFIQNGLIQQIITEKRREDISQTFEVSGNKYTSYIDVS
SGIFYFFDSFVGNRQLADASMLRPVVGIISVDNYDDITDDLSDADTSKIN
SFVANFIDEFMESKRIFYRRVNMDRYYFFTDFKTLNDLMDNKFSVLEEFR
KEAQDAQRPLTLSIGISFGEENHSQIGQVALENLNIALVRGGDQIVIREN
ADHTNPIYFGGGSVSTVKRSRTRTRAMMTAISDRIKMVDNVFIVGHRKLD
MDALGSAVGMQFFAGNIIENSFAVYNPDEMSPDIERAIERLQADGKTRLI
SVSQAMGLVTPRSLLVMVDHSKISLTLSKEFYEQFQNVIVVDHHRRDDDF
PDNAILTFIESGASSAAELVTELIQFQNAKKCLNKIQASVLMAGIMLDTK
NFSTRVTSRTFDVASYLRSKGSDSVEIQNISATDFEEYKQINEIILQGER
LGDSIIVAAGEKNHLYSNVIASKAADTILSMAHVEASFVLVETASHKIAI
SARSRSKINVQRVMEKLGGGGHFNLAACQLTDISLPQAKYLLLKTINMTM
KETGEVES
>M5005_Spy1266 ATP-dependent protease La
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGK
EDKRKGAYQFVAVGISRASLAQLLYAWLTPFTEISTAEDTTGGYSDADFL
RINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHL
ADTVTGVNGKQFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIK
LKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMFTLDIYDQITK
EDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVD
KEIKKVNPNAISNYEEAKRAAKRLKTKMKIVPVTTVQEALVYLRK
>M5005_Spy0596 arginine-binding protein
MNFKKIRFGFLLCLLLYPLAACNKSEQLNHYERIKKTRKLVVAVSPDYAP
FEFKALVNGKDTIVGADVQLAQAIADELDVDLELSPMSFDNVLSSLQTGK
ADLAISGISHTKERAKVYDFSIPYYQAENAIVMRASDAKVTKNISDLNGK
KVAAQKGSIEEGLVKIQLPKANLISLTAMGEAINELKAGQVYAVTLEAPV
AAGFLAQHKDLALAPFSLKTSDGDAKAVALPKNSGDLTKAVNKVIAKLDE
QERYKSFIAETIALTKNTMK
>M5005_Spy0680 two-component response regulator
MKILLAEDEWQMSNVLTTAMTHQGYDVDVVFNGQEAIDKAKDNAYDIMIL
DIMMPIKSGIEALKEIRASGNCSHIIMLTAMAEINDRVTGLDAGADDYLT
KPFSLKELLARLRSMERRVESFTPQVLQFAGVTLNINEQELSAGNAIRLA
SKEGKLMAFLMLNQGKYLDTKTLYQHVWSDQEDYDTSIVWVYISYLRQKL
LAIQANVIIAGDKDTSYCLLEK
>M5005_Spy1113 GAF domain-containing proteins
MNKSKKIEQYQLMIAQAKELFANESNALANLSNASALLNMTLPNSVFTGF
YLFDGQELILGPFQGRVSCVHIKLGKGVCGESAQSRRTIIINDVKQHANY
ISCDAAAMSEIVVPMVKEGHLIGVLDLDSSLVADYDEVDQEYLEAFVDLF
LEKTTFTFNMFGVKN
>M5005_Spy1276 transcription regulator, crp family
MIRREDYQYLRKLNDFRYFSIEQFDKIVGQMEFRKAKKDHILFFEGDKRD
KLFLVTSGYFKVEQSDQSGTFMYTDFIRHGTIFPYGGLFTDDYYHFSVVA
MTDVTYFYFPVDLFEDYSLENRLQMKHLYSKMSKLLELHELRVRNLITSS
ASSRVIQSLAILLVEMGKDSDTLPFQLTTTDIAQISGTTRETVSHVLRDL
KKQELITIKGKYLTYLDKDYFLQYTK
>M5005_Spy0785 two-component response regulator
MYKLVIIEDEHIIRKWLRYAIDYKALDILVIGEAKDGKEGAVLIKESQPD
IVLTDINMPIMTAFDMFEVTKDQTYAKIILSGYADFPNARSAIHYGVLEF
LTKPIEKAALWECLQTIIAKIEKQKGSNQKTDACVYIPLPQMTDQIPEVV
KDILEWVHAHFQDKISTSRLAHDLGYSESYIYQNIKKHLQMPLSDYINQY
RINQAIQLMQQEPDLMVYEIAQAVGIYDYRYFDRVFKKYLGQTVKAFKEE
HFMKDTDRSKPC
>M5005_Spy1305 two-component response regulator
MYKVLLVDDEYMILQGLTMIIDWQALGFEVVQTARSGKEALAYLTQYPVD
VMISDVTMPGMTGLDLIEAAKTYHPQLQTLILSGYQEFSYVQKAMELETK
GYLLKPVDKAELQAKMKQFKDWLDAQQAESIRQEAYHDSLLTLWLTDELS
EKEFQQLSQGLPAAALTGFTVLYLDCQEWQAAIDAYFEREGQPFYLKKEE
DKKVYLAVLLGKTDQAKAFTYDLQKRFSRNMHQLILGETVDDWENVYESY
NQVLKSLFYNCEVSPIRAKDKSKIELPESRLQFFAFNKALMIGDEPTILS
KLEAIFDEMKTLNFSPEDVKHVSFLLFSDIYRQFPILDKMTYLSMVKTIH
DSQSIDCILRELKKVLDVTNQNNSPEKRYSDLVSETIDCIRKEYHQELTL
KAIADRLHVNGVYLGQCFKNETERSFTQYLNHVRIQKAQQLLLYTNQSIN
EIAYETGYNTNHYFIKMFKKLNGLSPKEFRDRYKDNYQAIKGDQ
>M5005_Spy0868 hypothetical protein
MLDSYIKRIVIHQFSPNDTELLLSDRLVSITPRIDEYFRKKLAKVFSDEA
KRGQFEANNTFFTTIGDDLLETSVTIAQLWKEAFVISEDQKTNDLVFVQF
DKDGEPFFAFLRIALKEQFAHLSDNYEHPFTVTQNNLPSPTQTPDEALVI
NLKSGQYYLIEKRVKHNGSFANYFSEHLLKVTPEQSVKKSIKMIEQTAQK
IAEHFNQDDFTFQSKMKSTLFKQLEADDVLSPEKLADQLFDDNLTARLTF
VDQVKDVIPEPIKISDIEHSRQIKKLENQKLSLSNGIELTVPNAIYQDAE
AVEFLLNDDGTYSILIKNIEDIKTK
>M5005_Spy1416 phage-associated cell wall hydrolase
MTFLDNIKQGCLDGWTKYKILPSLTAAQAILESGWGKHAPHNALFGIKAD
ASWTGKSFNTKTQEEYQPGIVTDIVDRFRAYDSWTDSIIDHGKFLNDNPR
YQSVVGETDYKKACHAIKDAGYATASGYAELLIQLIEENDLQKWDKEILT
NQKEVTMTTANEIVKYCVDLANSGMGVDKDGAYGTQCCDLPCFIVKNWFG
IDLWGNAIDLLNSASAQGLEVIYNAPGVNPKASDLFVMEVAGSPYGHTGA
VIEDSDGYTIKTVEQNIDGNWDSLQVGGPARFNTRDFTGVVGWIRLPVDH
AHQTVDTAPQNSDTIVETPKSGTFTLDVVEINIRRWPSLASEVVGSYKQG
DTVSFDSEGYANGYYWISYLGGSGMRNYMAIGITDKDGNIISLWGKLN
>M5005_Spy1574 universal stress protein family
MALFLVGTIGLSTFRYMTIGLTSEYRLCHVKIDLLIVRANKKCYNTMK
>M5005_Spy0270 ABC transporter substrate-binding protein
MIKKQYLGRATIALASTLVLAACGSSKTAESGNQGSSKEVLFATVGTTAP
FSYEKGGQLTGYDIEVAKAVFKGSDDYKVSFKKTEWSSIFTGLDSGKYQM
GGNNISFTKERSAKYLFSYPIGSTPSVLVVPKDSDIKSFDDIQGHTTQVV
QGTTSVAQLEDFNKKHSDNPVTLKFTNENITQMLTNLSEGKADFKIFDAP
TVNAIIKNQGLDNLKTIELTSTEQPFIYFIFSQDQEKLQSFVNKRIKELT
ADGTLSKLAKEHLGGDYVPSDKELKLPTAN
>M5005_Spy0681 two-component system histidine kinase
MFNRIRIRFIMIASIAIFIILSSIVGIINTARCYQSQQEINRILHLISSN
KGKLPGTTESSKRLGTKLSEDSLSQFRYYSVIFNANGHLLSSNTANISAL
DREEAQYFARLFAKSGEEKGSYRHQDSVYSYLITQLPNEEKLVVILDTTF
YFRSVGDLLAVSVMLAFGGFIFFVVLVSLFSGMVIKPFVQNYEKQRRFIT
NAGHELKTPLAIISANNELVELMTGESEWTKSTSDQVKRLTGLINQMITL
ARLEEQPDVVLHMVDFSAIAQDAAEDFKSLVLKDGKRFDLTIQPNIMIKA
EEKSLFELVTILVDNANKYCDPKGLVKVSLTTIGRRRKRAKLEVSNTYLE
GKSIDYSRFFERFYREDESHNSKEKGYGIGLSMAESMVKLFKGTITVNYK
NDAIVFTVVI
>M5005_Spy1626 sensory transduction protein kinase
MIRIKNITKSKFFGTAIILLQQLIALLILVYNRENLSLLFSEKVALVMTL
IDTAFIWLATILRQKQGDIFKRIISIISLTIWQYLVSVLTRGTPLFLSSG
LQIILLYCYTVEITNLILYGHKQFKDKLDKGLLIIIFVSITSLFVNRILF
NFLFLMVFTILHLYPLLVIVLYYRSFRQQISVVRRSLILFSLLLLVILGS
ELYGEMLDVNQAFNNLGWYLFPLIMSVIYYFKTIHDKLSFVTQRWLGDYK
ARIELLFLLLILCWIVLMKVLVKDFLLFFIVVDASTLFCLVVISCIFYYL
ENSKQNFDYENRRLNYFMKSEENMRVEFSNYLHDDVLQNIIAIKNLFSLE
NSNITHGFIVNELNDLVSGIRDEMDTYHPIVPANQTMKENIQSLFDDIVK
SRKSNTLLYFNCSDNMVVPSPYGDIVYRFIKELINNAIKYGDGKDIRLSL
TIQSDIIIIEESNQVVEKVHSINYGRGLKSFQETLAAFDGDLELQMDTKQ
FTIRILLPIDWKLCYEDFIN
>M5005_Spy0981 cfa, cAMP factor
MKPKHLLCLSTVVAGLALFSTMTHSVLADDASNPDTILMNNNQANFQRDA
LVQKLDEGHQQLEAIKHEAKGTDIETTVNKAIDAVDHMKSSIRFNTETIY
DFSSIGARVEALSDAIKAIVFSTTQLTHKVEKAHTDMGFAITKLVIRIID
PFASVDAIKAQVQEIKALEEKVINYPDLQPTDRATIYTKAKLNKAIWNTR
LERDKKVLGIKPFDVYNRLNKAITHAVGVQLNPTTTVQQVDDEVIAVQDA
LETALKS
>M5005_Spy0947 ciaH, sensor protein
MNKLKKEILSDNYNHFFHFFAVFTGIFVIMTIIILQIMRFGVYSSVDSSL
VSVSNNASSYANRTMARISSFYFDTENNIIKALPDSDSSKLLGTPAANTD
IILFSANGTILNAFDAFSNYQNFHLDKRRLGSIETTSLMNFYGQEEKYHT
ITVGVHIKNYPAVAYMMAVVNVEQLDRANERYERIIIIVMSVFWLISILA
SIYLAKWSRKPILESYEKQKMFVENASHELRTPLAVLQNRLESLFRKPNE
TILENSEHLASSLDEVRNMRILTTNLLNLARRDDGINPQWTHLDTDFFNA
IFENYELVAKEYGKIFYFQNQVNRSLRMDKALLKQLITILFDNAIKYTDK
NGIIEIIVKTTDKNLLISVIDNGPGITDEEKKKIFDRFYRVDKARTRQTG
GFGLGLALAQQIVMSLKGNITVKDNDPKGSIFEVKL
>M5005_Spy0948 ciaR, transcriptional regulatory protein
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILL
DLMLPEKNGFQVLKELREKDIKIPVLIMTAKEGLDDKGHGFELGADDYLT
KPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVEL
LGKEFDLLVYLLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKK
LKGTCFVNRLQTLRSVGYILKNNE
>M5005_Spy0282 covR, response regulator
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLI
LLDLMLPEMDGFEVTRRLQTEKTTYIMMMTARDSIMDVVAGLDRGADDYI
VKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGD
DEISLTKREYDLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIR
YLRGKIDIPGKESYIQTVRGMGYVIREK
>M5005_Spy0283 covS, transmembrane histidine kinase
MKKEKQSVFQAVNIVRVRLSEVDSNFTLENLAEVLYKNDKTHLRIDDRKG
SRVIRSERDITNTLDANQDIYVYNIDKQMIFTTDNEESSPGLHGPIGRVY
HDHIEDQYRGFSMTQKVYSNRTGKFVGYVQVFHDLGNYYVIRARLLFWLL
VVELFGTSLAYLIILITTRRFLKPLHNLHEVMRNISENPNNLNLRSDISS
GDEIEELSVIFDNMLDKLETHTKLQSRFISDVSHELRTPVAIIKGHIGLL
QRWGKDDSDILEESLTATAHEADRMAIMINDMLDMVRVQGSFEGHQNDMT
VLEDSIETVVGNFRVLREDFIFTWQSENPKTIARIYKNHFEQALMILIDN
AVKYSRKEKKIAINLSVTGKQEAIVRVQDKGEGISKEDIEHIFERFYRTD
KSRNRTSTQAGLGIGLSILKQIVDGYHLQMKVESELNEGSVFILHIPLAQ
SKES
>M5005_Spy0830 dpiA, transcriptional regulatory protein
MNVLIIEDDPMVDFIHRNYLEKLNLFDRIISSDSMKAVQSILTDYAIDLI
LLDIHITDGNGIQFLEKWRTQHIPCEVIIISAANDGNIIRDGFHLGIIDY
LIKPFTFERFQESIQQFVTHREHLANQQLEQAQIDQLKCLTSKKDTKNKQ
LLEKGLSESTFQWIMENIKVFDQPFTIQELASACHLSHVSVRKYIAYLEE
NKQLNSQQIFTKVGRPYRVYW
>M5005_Spy0831 dpiB, sensor kinase
MKKPLRLWASLSLILVSMIVVTTSLFYGIMLHDTHQSIKNQETHLLTSTG
KMLASHQAIKELLLNNQPNAKTTAYTNSIASIYNLDYVVVMNMKGIRLTH
PNPKNIGKPFQGGDEEAVLAGKKVISTAKGTLGKSLRYLVPVFDGDKQIG
AIAVGIKLTTLNDVALTSKRNYTLSLLLCLLISLLVTSFISFRLKRQLHQ
LEPSEIYQLFEERNAMLDQIEAAVFVVDKAGILQLCNQAGQKLIARKCQL
GKPTGNSFNYLFPDFPKLSLQEGHEQLFRYGEEDYLLAISPICVKNDHRG
HIIFMREAVKAIDTLDQLAYTTAYASALQAQTHKFMNQLHVIYGLVDIAY
YDQLKIYLDSILEPENEILTSLSVLVKEPLLASFLIGEQEKYQELNVHLK
IDVLSEIPHSATKNQLNNGLMIYRFIHTNLLTTLRPKSLVLSIQHDQNHL
ISHYTLTDNWIDLERVQPIFDLPYFQQLLTDTNSQFHQHQTVTELQFSVT
TPYVGGQHERFNH
>M5005_Spy0206 fasA, response regulator
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQE
RGDHQLYFLDIEIGEYTRCGLELAAAIRQKDPNAVIVFVTTHSEFAPISF
KYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQT
RLKLPYKDILYFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCH
RSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFERWEALR
>M5005_Spy0204 fasB, sensory transduction protein kinase
MANSEYMFLLLSIIVYYMTKIYIFSFLSDITLPVWKQLTILALALFFNQF
PYLSPLLIDPLLFLVVLRQETKQLFSLKALFLAVAPSVLVDLLSRFMGTI
VIPYLFLSSGIYLGHIIFDLLAYLLIFPSFAIINYMIGKDYKMICQSGYS
KRSHNFYQTLLIFVLVYYVDIFVILGFTDPFLHFHHSLFVPTPYKLLFLM
FILLLVYLLSYFNHSSKEYLKNELRREQQAYMTNLEIYGKHLEKLYRDVR
AFQSDYLSRIERLGQAIKSESITQIQDIYAQTVHEANDYWDDKHYNISKL
RKINISSIKSLLSAKIISAEKSGIDLNVEVPDNIKETYIPELDLLLLMSI
FCDNAIEAALEAQQPHMSIAYFLLGDYQMFVVTNTTKKKVDINKIFEEGY
SSKGSERGIGLSNAQRILKKYPYLSLRTKSFDKEFSQTLTMPKEEVDR
>M5005_Spy0205 fasC, sensory transduction protein kinase
MMVIYSMALFYATIFINSWVIFAKVSAIKLSWKRVSIIGISFVIANMIFD
KVILIDQLFFIIVSLLSAPKKKLFEHMFNGFFTILIVELLFRVIGSFFLP
AVLGFSIGQINNNLKLLELCYLFVLPIFYLFSYIFSIDLSLIRFISEDKM
KKWVFWMNTAMFSYYFFAHFLVTVQSGFLALYFQYRSILVFIYLAIFIWV
IVKLDRFAKDQLSQKLTQAQNERIAYLENYNQSIEQLYREIRTVKHDSEN
ILISLKDSIDSGDIDLITRVYDTVIQQSATSMMRTNYEISSLDNIKEAVI
RSIMNSKLLEAQYLGIELYIEIPDVIDHLPIKLIDLIVLFTGLVDNAIET
AKGSRRPFLSIAYFKQDNKQLFIIENSTKTNRVDIAKRFDAQQQNSAHFL
TVLDSYPQITLSTKSDHYRLRQLLEMR
>M5005_Spy0662 fruA, PTS system, fructose-specific IIABC component
MKIQDLLRKDIMILDLQAISKEVAIDEMITKLVEKDIVHDFDVFKKSIMT
REEQTSTGLGDGIAMPHSKNIVVDKPAVLFAKSNKGVDYKALDGQPTDLF
FMIAAPQGANDTHLAALAELSQYLLKDGFADKLRAAATPEAVIAVFDEAS
TAKEEVVAPTSGQDFIVAVTACPTGIAHTYMAEEALKKQAAEMGVAIKVE
TNGASGVANRLTAEDIQRAKGVIVAADKAVEMDRFDGKQFIARPVADGIK
KSQELISLILNNEGNTYHAKNGKSETAVSTEKTSLGGAFYKHLMGGVSQM
LPFVIGGGIMIALAFLLDNMLGVPNDQLGSLGSYHEIAAIFMNIGGAAFS
FMLPVLAGYIAYSIAEKPGLVAGFVAGAIASNGLAFGKVPFAAGGEVSLG
LTGVPSGFLGALVGGFLAGGVILALRKLLAGLPRSLEGVKSILLYPLLGV
LVTGFLMLFVNIPMAAINTALNDFLQGLSGSSAVLMGLLVGGMMAVDMGG
PVNKAAYVFGTGTLAATVANGGSVVMAAVMAGGMVPPLAVFVATLLFKDK
FTKEERESGLTNIVMGLSFITEGAIPFGAADPARAIPSFIAGSALTGALV
GLAGIKLMAPHGGIFVIALTSNPILYLVFVVIGALVSGILFGALRKKA
>M5005_Spy1076 glnH, transporter
MTHKIKVLLLAIMSIFLTCNIASAETIAIVSDTAYAPFEFKDSDQIYKGI
DVDIINEVAKRQSWDFSMSFPGFDAAVNAVQSGQASALMAGTTITNARKK
VFHFSEPYYDTKIVIATRKANAIKKYSDLKGKTVGVKNGTAAQAFLNNYK
KKYDYTVKTFDTGDLMYNSLSAGSIAAVMDDEAVIQYAISQNQDIAINMK
GEPIGSFGFAVKKGSGYDYLVNDFNTALKAMKADGTYQAIMTKWLGTDDK
ATTSQATGNPSAKATPTKDSYKIVSDSSFAPFEFQNGKGKYVGIDIELIK
AIAKQQGFKIEIANPGFDAALNAVQSSQADGVIAGATITDARKAIFDFSD
PYYTSNIILAVKAGKNIKNYEDLDRKTVGAKNGTSSYSWLKENAPKYGYN
VKAFDDGSSMYDSLNSGSVDAIMDDEAVLKYAISQGRRFETPLEGISTGE
VGFAVKKGTNPELIEMFNNGLAALKKSGQYDDIIDKYLDSKKAATPSEKG
ADESTISGLLSNNYKQLLAGLGTTLSLTLISFAIAIIIGIIFGMMAVSPT
KSLRLISTVFVDVVRGIPLMIVAAFIFWGVPNLIESMTGHQSPINDFLAA
TIALSLNGGAYIAEIVRGGIEAVPAGQMEASRSLGLSYGTTMRKVILPQA
VKLMLPNFINQFVISLKDTTIVSAIGLVELFQTGKIIIARNYQSFRMYAI
LAIIYLIMITLLTRLAKRLEKRLN
>M5005_Spy1724 ihk, two component system histidine kinase
MRLIKKTFLVINGLIIVVVTSILLVLYFAMPIYYTKVKDKEVKCEFDQTS
KQIKGKTVTEIRDILTKKINKDNIWYSLVDSDNQLLYPSLQLLDGVSESK
DSQNVNIVTTFDNSYSNVKVMSQKVTLRDGKKMTLLGQSSLQPVTDASKV
LLDLYPSLLIFSVTVGSIVAYLYSRTSSRRILSMSQTAKKMVNLEPNLTC
TIHGKDEIAMLASDINRLYASLSTSIKSLQKEYEKASDSEREKSEFLRMT
SHELKTPITSVIGMIDGMLYNVGDFADRDKYLRKCRDVLEGQAQLVQSIL
SLSKIETLASQNQELFSLKSSLEEEMEVFLVLSELKHLKVTINLEEQFVK
ANKVYLLKAIKNIIDNAFHYTKSGGQVMIQLKDNQLVIKNEAETLLTQQQ
MKQLFQPFYRPDYSRNRKDGGTGLGLFITHQILDQHHLAYRFVVLDQRWM
VFTIDFPSHHDD
>M5005_Spy1725 irr, two-component response regulator
MFKILVVEDDDTISQVICEFLKANNYDPDCVFDGQAALDKWQTTSYDLII
LDIMLPSLSGLEVLKTIRKTSDVPIIMLTALDDEYTQLVSFNHLISDYVT
KPFSPLILIKRIENVLRVSTPDEKRQIGDLLVDETEHSVYWQGTLVKLTK
KEYDIIDYLAKRHQKIVTRDQLMDDIWGYSELDTRVLDNHIKNLRKKMTG
IPLKTITGMGYLLGERE
>M5005_Spy1683 lrp, leucine rich protein
MELKDYFPEMQVGPHPLGDKDWMSIKEGDQYVHFPKSCLSEKERLLLEVG
LGQCEVLQPLGSPWQRYLLDHQGNPPQLYETSQFIYLNHQQALPDDLVEL
LQQMIAGLEVILPISATQTAFLCRQAISIKVLRWLEDLLPTLESDFGLAL
TMFVGNAWYQVAAGTLRECFEEECQLLTAYLRQQSGRKLLTFSGLMLWSL
LSHHTFLALTRQFHQFLSPQSDMADVVHALWSEHGNLVQTAQRLYIHRNS
LQYKLDKFAQQSGLHLKQLDDLAFAHLFLLKY
>M5005_Spy1349 luxS, autoinducer-2 production protein
MTKEVIVESFELDHTIVKAPYVRLISEEFGPKGDRITNFDVRLVQPNQNS
IETAGLHTIEHLLAKLIRQRIDGMIDCSPFGCRTGFHLIMWGKHSSTDIA
KVIKSSLEEIATGITWEDVPGTTLESCGNYKDHSLFAAKEWAQLIIDQGI
SDDPFSRHVI
>M5005_Spy0239 mecA, negative regulator of genetic competence
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDL
PDNFKDSGMLSFRVTPRKDRLDVFVTKSEINKDINLEDLAEFGDMSQMTP
EDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTN
HESEPLDYVHYVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILL
DVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLMLDGAVEQLQKI
ELG
>M5005_Spy0386 phoH, phoH protein
MQEYSIDITLTHPDDVLALFGSNERHLKLIEAHLGVIVHARTERVQVIGD
DEEAVELARLTIKALLVLVGRGMVVNTSDVVTALSMAESHQIDQFMALYE
EEIIKDNYGKAIRVKTLGQKTYVDSVKRHDVVFGVGPAGTGKTFLAVTLA
VTALKRGQVKRIILTRPAVEAGESLGFLPGDLKEKVDPYLRPVYDALYHI
LGKEQTTRLMERDVIEIAPLAYMRGRTLDDAFVILDEAQNTTIMQMKMFL
TRLGFNSKMIVNGDTSQIDLPRNVKSGLIDATQKLQGIKQIDFVYFSAKD
VVRHPVVADIIKAYETSSEEMKDLLKPKASDVEADYQPGLTKYPVIGQEH
>M5005_Spy1336 pppL, protein phosphatase 2C
MKISLKTDIGQKRSNNQDFINKFDNKKGITLVILADGMGGHRAGNIASEM
TVTDLGREWVKTDFTELSQIRDWLFETIQSENQRIYDLGQSEDFKGMGTT
VEAVALVESSAIYAHIGDSRIGLVHDGHYTLLTSDHSLVNELVKAGQITE
EEAASHPQRNIITQSIGQASPVEPDLGVRVLEPGDYLVINSDGLTNMISN
DEIVTILGSKVSLDEKNQEMIDLANLRGGLDNITIALVHNESEDVE
>M5005_Spy0229 prgA, surface exclusion protein
MDLEQTKPNQVKQKIALTSTIALLSASVGVSHQVKADDRASGETKASNTH
DDSLPKPETIQEAKATIDAVEKTLSQQKAELTELATALTKTTAEINHLKE
QQDNEQKALTSAQEIYTNTLASSEETLLAQGAEHQRELTATETELHNAQA
DQHSKETALSEQKASISAETTRAQDLVEQVKTSEQNIAKLNAMISNPDAI
TKAAQTANDNTKALSSELEKAKADLENQKAKVKKQLTEELAAQKAALAEK
EAELSRLKSSAPSTQDSIVGNNTMKAPQGYPLEELKKLEASGYIGSASYN
NYYKEHADQIIAKASPGNQLNQYQDIPADRNRFVDPDNLTPEVQNELAQF
AAHMINSVRRQLGLPPVTVTAGSQEFARLLSTSYKKTHGNTRPSFVYGQP
GVSGHYGVGPHDKTIIEDSAGASGLIRNDDNMYENIGAFNDVHTVNGIKR
GIYDSIKYMLFTDHLHGNTYGHAINFLRVDKHNPNAPVYLGFSTSNVGSL
NEHFVMFPESNIANHQRFNKTPIKAVGSTKDYAQRVGTVSDTIAAIKGKV
SSLENRLSAIHQEADIMAAQAKVSQLQGKLASTLKQSDSLNLQVRQLNDT
KGSLRTELLAAKAKQAQLEATRDQSLAKLASLKAALHQTEALAEQAAARV
TALVAKKAHLQYLRDFKLNPNRLQVIRERIDNTKQDLAKTTSSLLNAQEA
LAALQAKQSSLEATIATTEHQLTLLKTLANEKEYRHLDEDIATVPDLQVA
PPLTGVKPLSYSKIDTTPLVQEMVKETKQLLEASARLAAENTSLVAEALV
GQTSEMVASNAIVSKITSSITQPSSKTSYGSGSSTTSNLISDVDESTQRA
LKAGVVMLAAVGLTGFRFRKESK
>M5005_Spy0484 ptsK, hpr(ser) kinase
MVSLFSFSSEKMSICKGLTVDLCYNIEKGEIMTVTVKMLVQKVKLDVVYA
TDNLLSKEITTSDISRPGLEMTGYFDYYAPERLQLFGMKEWSYLTQMTSH
NRYSVLKEMFKKDTPAVVVFRNLAIPKEMVQAAKEEGISLLSSRVSTSRL
AGEMSYFLDASLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKR
GHRLVADDRVDVYAKDEETLWGEPAEILRHLLEIRGVGIIDVMSLYGASA
VKDSSQVQLAIYLENFEAGKVFDRLGNGNEEITFSGVRIPRIRIPVKTGR
NVSVVIEAAAMNHRAKEMGFDATKTFEDRLTQLITKNEVSQ
>M5005_Spy1686 relA, GTPpyrophosphokinase/guanosine-3',5'-bis(diphosp hate)3'-pyrophosphohydrolase
MAKIMNVTGEEVIALAATYMTKADVAFVAKALAYATAAHFYQVRKSGEPY
IVHPIQVAGILADLHLDAVTVACGFLHDVVEDTDITLDEIEADFGHDARD
IVDGVTKLGKVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLHNMR
TLKHLRKDKQERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLNETEF
YKISHMMKEKRREREALVEAIVSKVKTYTTQQGLFGDVYGRPKHIYSIYR
KMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRFKDYI
AAPKANGYQSIHTTVYGPKGPIEIQIRTKDMHQVAEYGVAAHWAYKKGVR
GKVNQAEQAVGMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIYVFTP
TGAVQELPKESGPIDFAYAIHTQIGEKATGAKVNGRMVPLTAKLKTGDVV
EIITNANSFGPSRDWVKLVKTNKARNKIRQFFKNQDKELSVNKGRDLLVS
YFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFGDISPISVFNK
LTEKERREEERAKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQGASG
LLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHNIKSQDGYQERLIEV
EWDLDNSSKDYQAEIDIYGLNRSGLLNDVLQILSNSTKSISTVNAQPTKD
MKFANIHVSFGIPNLTHLTTVVEKIKAVPDVYSVKRTNG
>M5005_Spy1318 rocA, sensory transduction protein kinase
MLEDFLQFLGFIFLDIIEIMLTLKLFSFVSAIPLRLKNIFYLSLSMVLFQ
VVFWAFFPDHFILDVVMLAQFLFFALIALYYGKSIKAKFLMFYAFFPLVS
ISLVKRFIVFFVMPLFGMPYSVVKHNTLLIYSITCFSIFLIYRCIQVFHF
DFSTWRQYFQSHRASKLLVFTNSSMALYYLCVQGIDVMSPSLSGLATTTA
RSIIVLFYFILFLTLLIHLERYVKQNSIEAIVQQKEYRELINYSQHLGLL
YQDIQELRRLLTTVSSRLKIGIEQNDISIVRLTYEGILNAEKNNAKDDRL
DLTCLDKLQVEAIRHIVLAKLIEAKNKKLKVEVSIPNCIATFFLEVVDFT
KLLSFLLDNAIEMSLETKQPCLSIAFLDQNHKLVIVIQSSTKQGQDDSQS
VFAIPALKKRDDWQFDLRNVTTILNRYDYLTISSQIHDGILTQLIEIAKP
D
>M5005_Spy1625 salR, transcriptional regulatory protein
MKILLIDDHRLFAKSIQLLFQQYDEVDVIDTITSHFNDVTIDLSKYDIIL
LDINLANISKENGLEIAKELIQSTPHLKVVMLTGYVKSIYRERAKKVGAY
GFVDKNIDPKQLISILKKVDSGKKYFEQIESQDYVESLTDQEIAILNLSK
KGFSIKEIEETLQISRRTVFNHLTHIYSKLLVNNKQEAIYKAEQLGYFMD
F
>M5005_Spy0351 spyA, c3 family ADP-ribosyltransferase
MLKKRYQLAIVLLLSCFSLIWQTEGLVELFVCEHYERAVCEGTPAYFTFS
DQKGAETLIKKRWGKGLIYPRAEQEAMAAYTCQQAGPINTSLDKAKGELS
QLTPELRDQVAQLDAATHRLVIPWNIVVYRYVYETFLRDIGVSHADLTSY
YRNHQFDPHILCKIKLGTRYTKHSFMSTTALKNGAMTHRPVEVRICVKKG
AKAAFVEPYSAVPSEVELLFPRGCQLEVVGAYVSQDQKKLHIEAYFKGSL
>M5005_Spy0805 srtK, nisin biosynthesis sensor protein
MFKKYSIKNRVWRAVVEIVFGVCITVLMIAIISLSFSKLNIVTSHNVGEE
FYIKDKQSIKQLNNYMKTLGLDYVVFDRKTDKAMEGKYLSKEFSLFNEVA
EEKNNLTFNSVHYDLYTNINYNIVIRYNEIPEFSNHYLRNVSYNMLTFYI
LGIGTSISIVVALTRFVKEISLNFKEIKKLANKMGIEVLSENENYSKIIE
FDDILRTLHIKGDNLKSLIEREILEKQDLSFQIAALSHDIKTPLTVLKGN
LELLELTTLNKNQEGYIVSMNNSISVFEGYFNSLISYTRMLSEDRSVKLI
LVEELLSELHFEVDDLLNINNIEFSICNRLIITSFYGDEENLIRALSNLL
VNAIRFMPVLDKKIEVILSESGEQIHFEIWNNGERFSDSTLKKGDKLFYT
EDYSRGNKHYGIGLAFVKGVAIKHGGNLQLNNPARGGASAIISIKKKI
>M5005_Spy0804 srtR, nisin biosynthesis two-component response regulator
MYKILAIDDDKEILKLMKTALEIENYHVITCQEIELPIVFDDFKGYDLIL
LDIMMPNISGTEFCYKIREEVHSPIIFVSALDGDNEIVQALNIGGDDFIV
KPFSLKQFVAKVNSHLKREERAKIKNEAEERVKRSFPPIEIYLEERMLYI
DKQPLFLTYREYEILELLSRHPYKVFTKEEIYEQVYSDEASALFHSISEY
IYQIRMKFSSFGINPIKTIRGIGYKWDV
>M5005_Spy1576 srv, transcription regulator, crp family
MLISLEDTNYTLVKEYLEKSVNHHILQRYIDNHNFPIIEKSYHKYLTFES
LEEDFTYILKDGIVKQSVLSKYGMEFNLRYVTGLEITSVLNTGYSKDMGE
PYNVRIESEKASFYKVRRSAFLKDINEDIELQGYVKDFYHNRLQKSMKKM
QCMLTNGRIGAISTQIYDLMTLFGEELPNGQILINFVITNEELGKFCGIS
TASSVSRILKQLKEKNIIRIDKQHIIITNLDKLKDNIVF
>M5005_Spy1255 typA, GTP-binding protein
MTNLRNDIRNVAIIAHVDHGKTTLVDELLKQSHTLDERKELQERAMDSND
LEKERGITILAKNTAVAYNDVRINIMDTPGHADFGGEVERIMKMVDGVVL
VVDAYEGTMPQTRFVLKKALEQNLIPIVVVNKIDKPSARPAEVVDEVLEL
FIELGADDEQLEFPVVYASAINGTSSLSDDPADQEHTMAPIFDTIIDHIP
APVDNSDEPLQFQVSLLDYNDFVGRIGIGRVFRGTVKVGDQVTLSKLDGT
TKNFRVTKLFGFFGLERREIQEAKAGDLIAVSGMEDIFVGETITPTDCVE
ALPILRIDEPTLQMTFLVNNSPFAGREGKWITSRKVEERLLAELQTDVSL
RVDPTDSPDKWTVSGRGELHLSILIETMRREGYELQVSRPEVIIKEIDGV
KCEPFERVQIDTPEEYQGAIIQSLSERKGDMLDMQMVGNGQTRLIFLIPA
RGLIGYSTEFLSMTRGYGIMNHTFDQYLPVVQGEIGGRHRGALVSIENGK
ATTYSIMRIEERGTIFVNPGTEVYEGMIVGENSRDNDLGVNITTAKQMTN
VRSATKDQTAVIKTPRILTLEESLEFLNDDEYMEVTPESIRLRKQILNKA
ARDKANKKKKSAE
>M5005_Spy0436 vicK, two-component sensor histidine kinase
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRD
LINGRYTDIIDEKADIELMELSDQLNDLSDVFRLTHENLAQEKNRLASIL
AYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYT
YRDLVSKTPVVTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTT
EQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALKEDIAPSFIKV
SLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVK
NQHTGTGKVYEIVRDYPITSVWIEIDNDKMTQVIENILNNAIKYSPDGGK
ITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD
>M5005_Spy0435 vicR, two-component response regulator
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLII
LDLMLPELDGLEVAKEIRKTSHVPIIMLSAKDSEFDKVIGLEIGADDYVT
KPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAF
VAKKHGQEVELTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRT
VDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD
>M5005_Spy1332 yvqC, two-component response regulator
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKP
DVLVMDLVMPELGGVEATLEVLKKWKEAKVLVLTSYLDNEKIYPVIDAGA
KGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTA
REYDILHLLAKGYDNQTIADELFISLKTVKTHVSNILAKLEVGDRTQAVV
YAFRHHLVPQDDN
>M5005_Spy1333 yvqE, two-component sensor protein
MKKRYYALVWLYSTITILSIVFVVMDNLGITFNYLRNHLWQVERLGFSIL
LLIVSVTLLLLLLWIIMDDNSKRNINQNLKYILNNRRLYLDETSEINTNL
SRLSKKMSHLTANMQKKESAYILDSQEVVKQERKRIARDLHDTVSQELFA
SSLILSGISMSLEQLDKTQLQTQLTTVEAMLQNAQNDLRILLLHLRPTEL
ANRTLSEGLHMILKELTDKSDIEVIYKETIAQLPKTMEDNLFRIAQEFIS
NTLKHAKASRIEVYLNQTSTELQLKMIDDGVGFDMDQVRDLSYGLKNIED
RVNDLAGNLHLISQKGKGVSMDIRLPIVKGDDDE