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# Streptococcus pyogenes MGAS10394, MGAS10394

>M6_Spy0996 unknown phage protein
MAGAVALLSNPVTWGVLLGGAAVIGIGLIADSMYKAQKRTEEWGAAVSET
EATALSNFKKKVDETNASLQMFEAGAGSVKKVTEAFDDLVGSIEKLAQSK
LDKNINLAKKLGLSEETINALKSKTESVVNNVKSMNTQIKAIMEKHNGDM
SQLSSAEKELVLRNQREMIIAQLDLMKFSASEKKALTAALNNELDALNAR
QLEKVSENTVKMLDKENSAYKTKKAELKEILKQFGSDTGKLSAEELAARQ
EVLNRLTELNMQHNLKTKALNDQYLAIQRERVQRLKESGKSQEEIHQGIS
QMASDMAQKLGVSYDDAYRKLAYYTEKSGETLKVLSRNTANATAEVAAAN
AQWDSLFTSDNPQQSLNELLSTAEGWNSFEIMVKNADVEPTGRAALVEML
AAGGQWQNMSLEQKKLVVDGQQAMIEIFDSKELLAQWQVLTPEEKVLLAK
NLTQEPTMSAQQALDSVKQTVPADVNATDKTAGDTQSAQSKIDNVKQKAP
ADVKASDKTRPDVASANRAVNSPKQNSPAVIRAQDNASGVAENVIWSLAR
IPRSVTTTITTFVRKIFGHEKGTDFHPGGLAVVNDQKGALYRELVTLPTG
ESFIPTGRNVILPLPRGSKVLKASRTKQLFPHYANGIGFDDTKIASLTTR
LKFVQDKGTVVVNADPQLAELIKVLKDRDDRNVTNNYTLNATNSSSSEDM
FSQENMRRLLRELAYYTKGEEGRLA
>M6_Spy1747 Sorbitol operon regulator
MKEERRRLLAKVAYLHYIQGKSQTLISKEMNIYRTTVCRMLAKAKEEGIV
RIEIADYDADLFALEEYVRQQYGLEKIDLVPNQVEDTPMDTLTNVAKTAA
EVFRHVVKDGDKIGLSWGATLSCLMDELNPKAMKDVFIYPLAGGPSHINA
KYHVNTLVYRLARIFHGNSAFMNAMVIQEDKHLAKGILQSKYFNDILTSW
DQLDLALVGIGGEPNSLEQSQWRDLLTSSDHDQLKYEKAVGEVCCRFFDQ
AGQPVYTGLQDRTIGISLEQLRRVPKTMAVATGKHKAKAILAALKAGFIN
YLVTDKETMLAVLALDEDIDLNNVLL
>M6_Spy1808 Phage antirepressor protein
MKTRKDNLLRTETWNGYTIRFVEHNGEWWAVLADIAKALDLNPKFIKQRL
GDEVVSNNHVADSLGRQQEMLIVNEFGIYETIFSSRKKEAKTFKLWVFEI
IKQLRQSTGLEGFQVFRMFDKEHQKQAMNRLVNGLEQVKQTDLIKANTIA
NKAVSNKYGLPKMISKSQMTEQMLKDREQLLDDTVELMVIKDKFDLGISV
SNAIYSRATH
>M6_Spy1386 DNA-directed RNA polymerase omega chain
MMLKPSIDTLLDKVPSKYSLVILQAKRAHELEAGATPTQEFKSVKSTLQA
LEEIESGNVVIHPDPSAKREAVRAKIEAERLAKEEEERKIKEQIAKEKEE
EGEKI
>M6_Spy0433 Transcriptional regulator
MKVGKMEKELGKTLRRLRKGKQVSISFLADEYLSKSQISRFERGESEITC
SRLLNLLDKLNITIDEFVSAHSKTHTHFFTLLSQARKCYAEKNVVKLTKL
LKDYAHKDYERTMIKAILFSIDSSIAPSQEELTRLTDYLFKVEQWGYYEI
ILLGNCSRFMNYNTLFLLTKEMVASFAYSEQNKTNKMLVTQLSINCLIIS
IDHSCFEHSRYLINKIDLLLRDELNFYEKTVFLYVHGYYKLKQKEISGEE
DMRQALQIFKYLGEDSLYYSYKEHYRQIVLGGKGDEDWSEADL
>M6_Spy1784 Trehalose operon transcriptional repressor
MTKYERIYKDLETKINKDFYKEGDFLPTEIELSQQYQASRDTVRKALSLL
TKAGLILKKQGRGTQVIKHHQIMFPISELTSYQELVSYSNLDSKTNVIAI
DKLIVDETLSKLTGFSKNSLVWRVTRQRVVEGVASVLDIDYLSKTLVPIM
TREIAEHSIYQYLEKELHLAIDFALKEVTIDQITDRDKILLDLGSDQHVV
SVKSKVYLSNNNQFQFTESRHKLEKFKFLDFARRRPK
>M6_Spy0441 Exoribonuclease II
MMKERIMTYLKEHGKSNVNDLAAALEMAGAKQFPSLIKTISKMESQSLLR
FSDDGSLALRKEREKKKEPTVQGVFRANKAGFGFLHVDENEDDMFIGRND
VGYAIDGDTVEVVVKKPADRLKGTAAEAKIVAIVDRSLKTAVGTFILDDD
KPKYAGYIRSKNQKIQQKIYIKKEPVVLKGTEIIKVDIDKYPTRGHDYFV
ASVRDIVGHQGDVGIDVLEVLESMDIVSEFPAEVLAEANAISEAPTAKDL
IGRVDLRQETTITIDGADAKDLDDAIHIKLLDNGNYELGVHIADVSYYVT
EGSSLDKEAIARGTSVYVTDRVVPMLPERLSNGICSLNPNVDRLTQSALM
EINPQGYVVNYQICQSVIKTTYRMTYSTVNDMIAGDEEALQEFASIADDV
TLMVTLHRILEAMRSKRGALNFDTQEAKVIVNDKGMPVDVVLRQRGIAER
MIESFMLAANECVAEHFAKAKLPFIYRIHEEPKVEKLQQFIDYASTFGIH
IQGTANKISQEALQAFMAKVEGQPGAEVLNMMLLRSMQQARYSEHNHGHY
GLAAEYYTHFTSPIRRYPDLLVHRMVREYNQPSQEKRDHFAQIIPELATS
SSQLERRAIDAERVVEAMKKAEYMAEYVGEEFDGIVSSVVKFGFFVELPN
TIEGLVHITSLPEYYHFNERTLSLQGEKSGKVFKVGQPIRVKLVKADKET
GDIDFEYLPSDFDVVEKIKMSDKASRRDRRKSSKSSKGTKKKEPKEVAKA
KTKGKTKKGSKKPFYKEQAKKKSRKRS
>M6_Spy1589 Transcriptional regulator, Cro/CI family
MTKSTLKELRTTKKMTQQELSHLTGISVRTIARYEKDTKKLRRAKYEKLK
GIAQALAVSVDDIFLGIDSEFMN
>M6_Spy1333 Transcriptional regulator, GntR family
MQIGDRLPTEKELSEQFSVSRITSKRALVELEQEGLITRSRGKGSFVAKK
QVTSPEANKDLLLILPFASDYELGDYAKGIMTSIAETGYRLMVQLASTVR
LDTLSDYAGIIYYPEDVNHSIDFLFYCDHHHIPLVLLDKSLDLFQFPSVV
ADNKGGVYQLTQHLIEQGCDQISFVATGSFGEVSSVRDRYLGYLAAMAET
SLPSWYFPKEKAETSDAYLNRLVKTLSETTATKRGLVVENDWLAIQLIQK
ITQVGLSIPDQVAIVGFDNSQASRLLSPKLSTAAQDFYQMGQEAAKVLLQ
IIHEPDQAVVSCQLPVQVFIRESSH
>M6_Spy1469 Acetyltransferase
MIQQSLVIEEGVPQDAKAVLSLVTAAAKETDFITGVETILEATPQELSDF
LSRSQTSFIDFCLLARLDEKVVGLLNLSGEVLSQGQVEADVFMLVAKTYR
GYGIGQLLLEIALDWAEENPYIESLKLDVQARNTKAIYLYKKYGFRIESM
RKNDIKSKNGDDLDVYHMRKSVSQ
>M6_Spy0460 Transcriptional regulator, TetR family
MATSLITKKKIAKAFKKQLAVKSFDKISVVDIMDQAQIRRQTFYNHFLDK
YELLDWIFETELQEQVTHNLNYISGFQLLDELLFYFERNKTFYAQLFDIK
GQNDFSSYFVDYCQVLMAKIISEYQSQEMSQSDDADYLAFLTHYHARALA
DMIKGYVSQSEPKPCLTYLKQLILTSIH
>M6_Spy1707 Acetyltransferase
MIPIKALKIKVETVMKIIEYKGNYRDDLIFMVLEAKNALRRIPSINPDLL
TIETSYLEKGDCFWLAVNEESRVIGSIAYSSIPKTNEVFLHRLFIKPSLK
HQGIGSQLLTFAEDYLRKIGKSHVRIHLGQPKEQWFESYRFYPKHGYQFY
DDTHLIKKLI
>M6_Spy1648 Lactose phosphotransferase system repressor
MKKKERHEKILDILKVDGFIKVKDIIDEMNISDMTARRDLDTLADKGLLI
RTHGGAQYLDYSSAKDEGHEKTHTEKKVLQTTEKKQIAQRAKNIIKDGET
VFIGPGTTLEHLAVELKNRNIRVITNSLPVFLILHPCTTIDLILIGGECR
EITGAFVGAIAINNLETLTFSKAFVSANAVYNNSIATYSDLEGEVQRVAL
NNAVEKILLVDSTKFESYDFYNFYQLDQVDLIVTDKNVTTNIIEKYKKFS
KIIIADK
>M6_Spy1071 Transcriptional regulator, LytR family
MTKYPMGGLSHHEELRYFYLLRNLSYLSENEKKEFAFLKSKLEIGRAYAP
SKQHYRKSKRQEPYFEDDYYNDYSPNDLLEDDDVNHDSSFVPYGLPIYPK
EDRYLNKKTKLTARRPIDAPQPIDEDDAFLTESVARCALPRSQKRKHKKK
GCMKWFFNILGLLLMTVLMGLGLMFAKGVFDISTNKANYKPAVSQAFDGQ
ETQDGTNILVLGSDQRVTQGSTDARTDTIMVVNVGNHAKKIKMVSFMRDT
LINIPGYSYNDNSYDLKLNSAFNLGEQEDHHGAEYVRRALKHNFDIDIKY
YVMVDFETFAEAIDTLFPNGVKIDAKFATVGGVAVDSVEVPDDLRMKNGV
VPNQTIEVGEQRMDGRTLLNYARFRKDDEGDFGRTVRQQQVMSAVMSQIK
DPTKLFTGSAAIGKIYALTSTNVSFPFVVKNGVSVLGSGKNGVEHVTIPE
NGDWVDEYDMYGGQALYIDFDKYQKTLAKLGLR
>M6_Spy0185 Transcription antitermination protein
MKGNIMLDSFDKGWFVLQTYSGYENKVKENLLQRAQTYNMLDNILRVEIP
TQTVNVEKNGQTKEIEENRFPGYVLVEMVMTDEAWFVVRNTPNVTGFVGS
HGNRSKPTPLLEEEIRAILLSMGQTIDVFDTNIKEGDVVQIIDGAFMGQE
GRVVEIENNKVKLMLNMFGSETVAEVELYQIAEL
>M6_Spy0469 VicR
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLII
LDLMLPELDGLEVAKEIRKTSHVPIIMLSAKDSEFDKVIGLEIGADDYVT
KPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAF
VAKKHGQEVELTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRT
VDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD
>M6_Spy0913 Transcriptional regulator, GntR family
MTTKYQTIISNIEQDIQKQRLKKGDKLPSIRVLSKVYHCSKDTVQRALLE
LKYRHLIYAVPKSGYYVLGNVSIPDNVLNLSLEDYNNMAYEDFRLCLNEA
LSAKGKYLFHYYHKTEGLEELREALLLYLAENSVYSNKDQLLITSGTQQA
LYILSQMPFPNAGKTILLEKPTYHRMEAIVAQLGLPYQTISRHFNGLDLE
LLESLFQTGDIKFFYTISRFSHPLGLSYNTKEKEAIVRLAQRYQVYILED
DYLGDFVKLKEPPIHYYDTHHRIIYLKSFSMSVFPALRIGALVLPSGLKP
HFLTQKSLIDLDTNLLMQKALALYLENGMFQKNLRFIKRYLKQRERQLAL
FLKQNCPDIHYQLTPTHLVIDYTTSDSYRNFTLDKSDRIIITGKKRYLSI
AINQQIQSKLNSLIKNTCGKSN
>M6_Spy0251 Transcriptional regulator, RpiR family
MCFAMPKNHRLITKIEASLEHMTSLEKGIAHFFITTDLTPQELTASEIVK
RLHISQAALTRFAKKCGFTGYRAFAFDYLHSLQESQETFQSIHLELTKRV
LMDYDALINKTYELVNEEKLLNLAKLIDASERVYFFGKGSSGLVAREMKL
RFMRLGLICDAYSDTDGFTWANSLVNENCLVFGFSLSGKTNSVITALHQA
SQRGAKTVLLTTDNQTEFDDSLDIIPVSSTHQLHYGNRVSPQFPLLIMMD
IIYAYVLAIDKPHKEKIFKNTIIDKENNDL
>M6_Spy1459 Hypothetical cytosolic protein
MMSKVKKIPLRKSLVSGEIIAKRDLLRIVKTKDGQVFIDPTGKQNGRGAY
IKLDNQEALMAKKKQVFNRSFSMDIPESFYDDLIAYVDHKIKRRELGLD
>M6_Spy0250 N-acetylmannosamine kinase
MKHYLAIDIGGTAIKYGLISETGDLLEKEEMATEAYKGGPSILEKVKGLV
KTYQDQMDLAGVAISSAGMVNPDEGEIFYAGPQIPNYAGTQFKKEIEETF
GLPCEVENDVNCAGLAEAISGSAKDYPVALCLTIGTGIGGCLLFNSQVFH
GSSHSACEVGYLHLSDGQFQDLASTTALVQEVALAYGDDISQWDGRRIFE
QAKAGDAICIAAISKQVDYLGQGIANICYVVNPNVVVLGGGIMAQKDYLA
DKLKTALDSYLVSSLAKKTQLKFASHGNNAGILGAYYHFKQKNERSCSFI
TLEKIENNLASS
>M6_Spy1180 ATP-dependent RNA helicase
MKFIEFNLSQDIQSAVVTAGFEKASPIQEMTIPLALEGKDVIGQAQTGTG
KTAAFGLPTLNKIRTNENIIQALVIAPTRELAVQSQEELFRFGREKGVKV
RSVYGGSSIEKQIKALKSGAHIVVGTPGRLLDLIKRKALILDHVETLILD
EADEMLNMGFLEDIEAIISRVPADRQTLLFSATMPAPIKQIGVKFMKDPE
HVQIKNKELTNVNVDQYYVRVKEQEKFDTMTRLMDVNQPELSIVFGRTKR
RVDEITRGLKLRGFRAEGIHGDLDQNKRLRVIRDFKNDQIDILVATDVAA
RGLDISGVTHVYNYDITQDPESYVHRIGRTGRAGKSGESITFVSPNEMGY
LSMIENLTKKQMKPLRPATAEEAFQAKKKVALKKIERDFADETIRSNFDK
FKGDAVQLAAEFTPEELALYILSLTVQDPDSLPEVEIAREKPLPFKYVGG
GHGNKNGKGGRGRDNRNRGDRRGGYRGDRNRDERDGDRRRQKRGKRDGHD
GSGNRDFKRKSKRNSKDFFNKEKKSSAKNTGFVIRHKGE
>M6_Spy0164 Transcriptional regulators, LysR family
MNCKKKLFLKEVDFAILLTPTTLDATIADIDILLRDQLCLYMSHKTFQET
FDSNPNISIKALHRQNLVTFDKTFMINHQLTTLFEEANSLPVVKCYSASW
DFLLNCTRYSSYLTILPRPITHFAHIDSLVEVQLTEHPKWEVVLASLKHN
KTSHLKHYIKHTILDYFTNQRF
>M6_Spy0485 Transcriptional regulator
MRFSYNKLWKLLIDKGWTKTKLRQEAGISSSTIAKLGKGENIITDILLEI
CIALDCKIEDIVEIVDNNI
>M6_Spy0472 Ribonuclease III
MKQLEELLSTSFDIQFNDLTLLETAFTHTSYANEHRLLNVSHNERLEFLG
DAVLQLIISEYLFAKYPKKTEGDMSKLRSMIVREESLAGFSRFCSFDAYI
KLGKGEEKSGGRRRDTILGDLFEAFLGALLLDKGIDAVRRFLKQVMIPQV
EKGNFERVKDYKTCLQEFLQTKGDVVIDYQVISEKGPAHAKQFEVSIVVN
GAVLSKGLGKSKKLAEQDAAKNALAQLSEV
>M6_Spy0312 Putative regulatory protein
MRCPKCNYHKSSVVDSRQAEDGNTIRRRRECEQCHTRFTTFERVEELPLL
VIKKDGTREQFSRDKILNGVVQSAQKRPVSSTDIENVISRIEQKVRTTYE
NEVSSTAIGNLVMDELAELDEITYVRFASVYKSFKDVDEIEELLQQITNR
VRGKKKRLNNDETN
>M6_Spy0037 Phage-related DNA helicase
MRLHEYQEYAKTWIVEHPYCGLLLDMGLGKTLTTLSAIDEIQNIFSEDHK
ILIVAPKKVAEETWPTEIGKWHFDFTYSKVLGSEGKRIEALETEADIYLI
NRENVTWLVEYYKTKWPFTFVVIDELSSFKSSKSKRFRALRKVRPKVQRL
VGLTGTPAPNSLIDLWPQIYLMDRGARLETSQTRFKDKYFVPDKRNGLII
YSWALRDGAEAEIYNKIEDICVSMKAKDYLKLPPRTNNVVSVKLSNMKAY
KQLEADLVLEFKNKEISAANSAVLANKLLQMANGAIYDDDKATVAIHDDK
LDALENVVEESQGQPILVFYQYQHDLERLKKRFPQAEELTSVDKWNSGKI
PILLCHPQSAGHGLNLQKGGHIIVWFGLTWSLEYYQQANARLDRQGQTEP
VIVHHIVAENTVDEKVLRILQGKEKNQNALLEAVKAQLGV
>M6_Spy1759 Transcriptional regulator, MutR family
MMNHFGEIFKTFRESRGLRLKDVAKAGISTSQLSRFEKGETDLTISTFML
ILNESNMSIDEFMYAVHDFHRDDTTQDSDGLK
>M6_Spy1886 Chromosome partitioning protein
MFLILSRNSLMTKELLIDLPIEDIVTNPYQPRIQFNQRELQDLATSIKSN
GLIQPIIVRKSDIFGYELVAGERRLKASKMAGLKKIPAIIKKISTLESMQ
QAIVENLQRSNLNAIEEAKAYQLLVEKKHMTHDEIAKYMGKSRPYISNTL
RLLQLPAPIIKAIEEGKISAGHARALLTLSDDKQQLYLTHKIQNEGLSVR
QIEQLVTSTPSSKLSKKTKNIFATSLEKQLAKSLGLSVNMKLTANHSGYL
QISFSNDDELNRIINKLK
>M6_Spy0538 Transcriptional regulator, LacI family
MYAMQRKVTIKDIAELAKTSKTTVSFYLNGKFDKMSEETKNRIKSTIEAT
NYKPSIAARSLNAKSTKLIGVVIGDITNSFSNQIVKGIESKAQEFGYQII
IGNSNYDPSREDELIEKMLNLGVDGFIIQPTSNFRKYSRIIDIKKKKVVF
FDSQLYEHRTNWVKTNNYDAVYDTIQQCIDKGYEHFIMITGNPNLLSTRI
ERASGFIDVLEANHLTHQEMIIDENQTSSEAIAQFLQGSLTKKSLVFVPN
CWALPKVFTAMKSLKFNIPEIGLVGFDNIEWTKFSSPTLTTIIQPAYEEG
EQATKILIDDIEGHSQEAKQQIFDCQVNWQESTF
>M6_Spy0828 DpiA
MNVLIIEDDPMVDFIHRNYLEKLNLFDRIISSDSMKAVQSILTDYAIDLI
LLDIHITDGNGIQFLEKLRAQHIPCEVIIISAANDGNIIRDGFHLGIIDY
LIKPFTFERFQESIQQFVTHREHLANQQLEQAQTDQLKCLTSKKDTKNKQ
LLEKGLSESTFQWIIENIKAFDQPFTIQELASACHLSHVSVRKYIAYLEE
NKQLNSQQIFTKVGRPYRVYW
>M6_Spy1329 Glucokinase
MRHDRLFYYNKGEHLMSLLCLDIGGTSLKFALCHNGQLSQQSSFPTPSSL
EKFYQLLDQEVARYSAYHFSGIAVSAPGAVNKEKGIIEGASAIPYIHHFK
IQEALEERLHYPISIENDANCAALAEATLGAGKGASSLAMLVLGTGVGGS
LVIDGKIYHGAHLFGGEFGFMIMNDRYQTFSQLGTVVNMAKRYSAIVNNG
KDYTGKAVLALAEQGDPLALKERRVFLQSLAIGIFNIQHAFDPQLILIGG
GVSQADFLLSAIEAELDKLYQAVEISDLRPQLAICHFKNEANLLGAAIDF
YQEHKEA
>M6_Spy0024 unknown phage protein
MSDNTVAVEKIKKYLLDNKLKQVDLAVTYNKEPQDVANILAGRKKDPASN
RFVLKVISDLKIR
>M6_Spy0906 Transcriptional regulator, GntR family
MNNRLEECGMLPAYIKIHDAIKKDIDLGIWPIGSRLPSERHLAEHFTVSR
MTLRQAITLLVEEGILERRIGSGTYVASHRVQEKMRGTTSFTEIIRSQGR
QPSSKLLSYQKQLASDTEVKELNLDKTDLVIRMERIRYADSVPLVYEIAS
IPEKFIKTVKRADITEHFFHSLIANGYEIGKSKQTIYAKLASERVASYLE
VAKGHAILALTQVSYFTDGKPFEYVRSQYIGDRFEFYLENN
>M6_Spy1593 Transcriptional regulator, MerR family
MEMSQFYSTGELANLAGVSIRTVQYYDQRGILLSARFGIFH
>M6_Spy1451 Lactose phosphotransferase system repressor
MLKRERLLKITEIVNEQGIVTVNDIIQTLNVSDMTVRRDLDELEKAGKLI
RIHGGAQSITMPNKKERSNIEKQTVQTKEKWELASYATQLVNDGETIFIG
PGTTLECFAEQLKNRQIRIVTNSLPVFNILQDSETIDLILIGGEYRSITG
AFVGSLASQNISSLKFAKAFISCNGIYKNDIATYSETEGEIQKLAFNNSI
EKYLLVDNQKFNAYDFFIFYHLNNIDAVVTDSQITEDVIERYSQFTQLLV
AHENKE
>M6_Spy1634 Transcriptional regulatory protein
MKILLIDDHRLFAKSIQLLFQQYDEVDVIDTITSHFNDVTIDLSKYDIIL
LDINLTNISKENGLEIAKELIQSTPHLKVVMLTGYVKSIYRERAKKVGAY
GFVDKNIDPKQLISILKKVDSGKKYFEQIESQDYVESLTDQEIAILNLSK
KGFSIKEIEETLQISRRTVFNHLTHIYSKLLVNNKQEAIYKAEQLGYFMD
F
>M6_Spy0023 Phage transcriptional regulator, Cro/CI family
MFSTFEKIKELAKKQGKSLGQVEEDLNYGRNTLYKIKNSTPNAERLGEIA
NYFNVSTDYLLGRTDNPKIAQDGHTSVAIDLKKDAEETFFFDGHELNDED
IDLITSILETRIKNRK
>M6_Spy1837 Cadmium efflux system accessory protein
MDCVRLGENILKKDNICQVNVINQQNVTTATNYLEKEKVQKSLRILSKFT
DNKQINIIFYLLAVEELCVCDIACLLNLSMASASHHLRKLANQNILDTRR
EGKIIYYFIKDEEIRDFFNQLG
>M6_Spy1560 Portal protein
MYTESFRDSTGKTKTLEFRFHREARMRYQAESLESLLTEKYKLLREMIEH
HDKVQKPRIQELLDYAEGNNHTISEIGRRKDDDMADVRAVHNYGKYISTL
KQGYLVGNPIRVEYIDGTEQQQDLLKDLSVKNNFHQLNRRLVKDLSKVGR
AFELIYRSMDDKTEVVRLDPREVFVIYQNNLEQSSLAGVRYYNKNQLDGT
TKIVELYTDNKILKFEYDGDLTPIGEISSHAFGSVPITEYLNTDDGMGDY
ETELSLIDLYDAAQSDTANYMQDLSDAILAIIGRVSFPGYVDTAEKAIEY
LRKMRKARLLNLEPPVDQDGREGSVDAKYLYKQYDVNGTEAYKTRIVSDI
HKFTNTPDMTDSKFAGQQSGEALKWKVFGLDQERVDMQALFEQSLKRRYK
LIARISQLLKEIDGFDINRLKITFTPNLPKSLQEKIEAFKALGGELSQET
AMAITDIVEDAKKEISLINSESKSRSQLAQKLEETSRLTDRELAHDHQKE
>M6_Spy0474 Transcriptional regulator
MIISIAKIKIGKNFEIFFISGLPFSFYLLYNKKNGIDFCWESGKNMKSKL
GVTLRKVRKGKQISLCFVADEHLSKSQISRFERGESEISCIRLINILDKL
HITLDEFLILHDEDYTNSETFANLVQYIRKQYSSQNINNIACLLSDTSDY
TLNSFEKTMVKSILHTMDSSIIPSDDELLQLTDYLFKVEKWGYYEILLLG
NCVRTINYNSYFLLTKEMLNNYIYSSRNKTNKRIVTQLAINCFILSINKE
EFSNCSYLIDEIKTLLDNELNFYEQTVFLYATGYFEFKRQLETGVEKMKQ
AIQVLDILNEDKLKLHYADHFDKLVNKD
>M6_Spy0226 Transcriptional regulator, MarR family
MSQVIGDLRELIHQIEQISDEIAKKYDVEHLAGPQGYVLVFLAKHQNQEI
FVKDIEKQLRISKSVASHLVKRMVKNGFINVMPSQVDKRYKQVVLAQVGR
DKLPLLRECRKDIEHYFLKEITKEELLTAKKVIEQLKQNMLTYKGDNDA
>M6_Spy0937 CiaR
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILL
DLMLPEKNGFQVLKELREKDIKIPVLIMTAKEGLDDKGHGFELGADDYLT
KPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVEL
LGKEFDLLVYLLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKK
LKGTRFVNRLQTLRSVGYILKNNE
>M6_Spy0319 Acetyltransferase (GNAT) family
MLIRQVQGSDLEVIATIESDNFSPQEATTRAVLEERIRLIPDTFLVALID
QEIVGYIEGPVVTTPILEDSLFHGVTKNPKTGGYIAITSLSIAKHFQQQG
VGTALLAALKDLVVAQQRTGLILTCHDYLISYYEMNGFINQGISESQHGG
TLWYQMIWKL
>M6_Spy0132 DNA-directed RNA polymerase beta' chain
MVDVNRFKSMQITLASPSKVRSWSYGEVKKPETINYRTLKPEREGLFDEV
IFGPTKDWECACGKYKRIRYKGIVCDRCGVEVTRAKVRRERMGHIELKAP
VSHIWYFKGIPSRMGLTLDMSPRALEEVIYFAAYVVIDPKDTPLEPKSLL
TEREYREKLQEYGHGSFVAKMGAEAIQALLKRVDLAAEIAELKEELKSAS
GQKRIKAVRRLDVLDAFNKSGNKPEWMVLNILPVIPPDLRPMVQLDGGRF
AASDLNDLYRRVINRNNRLARLLELNAPGIIVQNEKRMLQEAVDALIDNG
RRGRPITGPGSRPLKSLSHMLKGKQGRFRQNLLGKRVDFSGRSVIAVGPT
LKMYQCGVPREMAIELFKPFVMREIVAKEYAGNVKAAKRMVERGDERIWD
ILEEVIKEHPVLLNRAPTLHRLGIQAFEPVLIDGKALRLHPLVCEAYNAD
FDGDQMAIHVPLSEEAQAEARLLMLAAEHILNPKDGKPVVTPSQDMVLGN
YYLTMEDAGREGEGMIFKDKDEAVMAYRNGYAHLHSRVGIAVDSMPNKPW
KDNQRHKIMVTTVGKILFNDIMPEDLPYLQEPNNANLTEGTPDKYFLEPG
QDIQEVIDGLEINVPFKKKNLGNIIAETFKRFRTTETSAFLDRLKDLGYY
HSTLAGLTVGIADIPVIDNKAEIIDAAHHRVEEINKAFRRGLMTDDDRYV
AVTTTWREAKEALEKRLIETQNPKNPIVMMMDSGARGNISNFSQLAGMRG
LMAAPNGRIMELPILSNFREGLSVLEMFFSTHGARKGMTDTALKTADSGY
LTRRLVDVAQDVIIREDDCGTDRGLLIRAITDGKEVTETLEERLQGRYTR
KSVKHPETGEVLIGADQLITEDMARKIVDAGVEEVTIRSVFTCATRHGVC
RHCYGINLATGDAVEVGEAVGTIAAQSIGEPGTQLTMRTFHTGGVASNTD
ITQGLPRIQEIFEARNPKGEAVITEVKGNVVEIEEDASTRTKKVYVQGKT
GMGEYVVPFTARMKVEVGDEVNRGAALTEGSIQPKRLLEVRDTLSVETYL
LAEVQKVYRSQGVEIGDKHVEVMVRQMLRKVRVMDPGDTDLLPGTLMDIS
DFTDANKDIVISGGIPATSRPVLMGITKASLETNSFLSAASFQETTRVLT
DAAIRGKKDHLLGLKENVIIGKIIPAGTGMARYRNIEPQAMNEIEVIDHT
EVSAEAVFTAEAE
>M6_Spy0918 SIR2 family protein
MSNWTTYPQKNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIGPRFE
TAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSY
LDLKEILETKDYHIITTNADNAFWVAGYDPHNIFHIQGEYGLWQCSQHCH
QQTYKDDTVIRQMIAEQKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVE
DADFHAQKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRVSENP
NALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISATKTIYQKS
>M6_Spy1738 Transcriptional regulator
MEIGETVEFIRHSKNISIKQVCGDYLTRQTYYRFIKNNLDISSKKLLYIL
DNLNVNVDEFLFISNNFKQYKEFIDMDTAKHYFECRNIEGLNHILDSYKD
SKSTKEKNLFALVKVLLATLTEEDCLTERTYLSNYLINIETWSHYETVLF
NNCMFIFESCFIEMVFSKVILNLDKYNTLRYYGNESIRMFVNMLILFIQR
QEYDKASEILAKIEDYQLNDDCLYERCCVSFFDGIIGLINGKEGAEQKCV
QILEIFQLLNCKTIHHMFQTYLEAIKHKLS
>M6_Spy0654 Transcriptional regulators, LysR family
MNIQQLRYVVAIANNGTFREAASKLFVSQPSLSVSIKDLEAELGFQIFNR
TTSGTVLTSQGLVFYEKALEVVKSFDSFEKTFSQADLDQNEFSIASQHYD
FLPPLITAFSQQYDGHRVFRIFESTTIQILDEVAQGNSEIGIIYLNVDNQ
KGLFQRMDKLGLEYVSLIPFTTHIYLSKTHPLANHEALYLNDIQGLPAVR
FTQERDEYLYYSENFVDTSECPRIYNVSDRATLNGILERTNAFATGSGFL
DHRSVNGIKVIPLADHIDNQMIYVKRKDKNLSVAGATFVTILKDYFDKRR
KALT
>M6_Spy0316 SWF/SNF family helicase
MMARLIPGRVRNEGIKLYEQGLVSFQDDNKGILQIEVETYQVQYGADDED
ITCQCDTFHMKHYCKHIAAVEYFLKNDQKGKLFLKQLTNQTKIKETTKKM
TSFGSLFLDSLAMNEDDSVKYRLSALGSRSPFSSDYWWSLKINRLPDDRS
YVIRDIKGFLQLIKKEGFYQIGKNYFEQLSWLQFDPSSQDLIEFLWRLAS
DTDKGDNENIFPNHARHLRLPSGFFEEGIHYLTSLYDFTFEGPSQTYHHL
FVRSLEAEAGLYEFKVEVHRKSIELQIAEKNVQYLFDNDYLLYQDTFYHL
TLKQRKMVQAIRSLPIEADLAKHIHFDLDDHAKLAASLSDFKQIGLVEAP
KSFAIRDFEVTFQFDLLNRDEISCQLMFDYGNYQVSDKASLEALPFASHL
KKEEKINRSLLAFGFSPQFYSKKRLTSAKELYTFFEETVPCFERLGNVAL
STAIQALQVKEMPKIAIKRNQGLLDISFDFSTIIENDIDQAVTALFQNNP
YFVSQTGQLVVFDDETQKVSKSLQELRARQLKNGHLQLDGIRALQVSKLF
EGMTSVHFSKELEELAYHLQHPETFSIKPLPVKAQMRDYQRNGVQWLSML
NHYGFGGILADDMGLGKTLQTLAFLASHLKSDSKVLILSPSSLIYNWFDE
CQKFTPQLDVVVSYGLKQTRDQIIEEGHQITITSYSSFRQDFETYQAFHY
DYLILDEAQVIKNAQTKISHCLRAFNTANCFALSGTPIENKMLEIWSIFQ
IVLPGLLPTKKEFLKLTAEQVSRYIKPFVMRRKKEDVLPELPDLIETNYS
NEMTDEQKAIYLAQLRQMQDQIRNSSDVDISRQKIEILSGITRLRQICDT
PSLFMDYQGESGKLDSLRILLTQIKENGHRALIFSQFRGMLDLAKQEMTA
LGLTSYQMTGSTPANERQEMTRAFNNGSKDAFLISLKAGGVGINLTGADT
VILIDLWWNPAVEMQAISRAYRIGQKENVEVYRLITRGTIEEKILELQES
KRNLVTTVLDGNESRASMSIEEIKEILGLNTH
>M6_Spy0617 RNA polymerase sigma factor rpoD
MTKQKEITTFNVQVAEFIRHHKKEGTAIDDDVTEKLVIPFALDADQIDDL
LERLTDGGISITDKEGNPSSKYIVEEPKPEELTDEELIGSNSAKVNDPVR
MYLKEIGVVPLLTSEEEKELAVAVAKGDLMAKQRLAEANLRLVVSIAKRY
VGRGMQFLDLIQEGNMGLMKAVDKFDYSKGFKFSTYATWWIRQAITRAIA
DQARTIRIPVHMVETINKLVREQRNLLQELGQDPTPEQIAERMEMTPDKV
REILKIAQEPVSLETPIGEEDDSHLGDFIEDEVIENPVDYTTRVVLREQL
DEVLDTLTDREENVLRLRFGLDDGKMRTLEDVGKVFNVTRERIRQIEAKA
LRKLRHPSRSKQLRDFIED
>M6_Spy1021 Phage transcriptional regulator, Cro/CI family
MTKMTLRALRVNYSLSAKEVAQELGIHQQTLLKYEIDSTDIPFSLLNELA
NYYNIDVNNIFLGKKFALKQIFKNNRLQN
>M6_Spy1533 Sucrose operon repressor
MVSKLTDVAALAGVSPTTVSRVINKKGYLSQKTVNKVNKAMRELGYKPNN
LARSLQGKSTQLIGLIFPNISNIFYAELIEHLEIELFKQGYKTIICNSEH
NPVKEREYLEMLAANQVDGIISSSHNLGIEDYERVEAPIVAFDRNLAPNI
PVISSDNFEGGKLAAQTLQKHGCQNIVMITGNDNSDSPTGLRQLGFNYQL
KRSAEIIKLPNNLSPVRREMEIKSILATRKPDGLFVSDDLTAILIMKVAK
QLHITIPEDMKVIGYDGTTFIQQYVPQLATIRQPIDEIAKLSVEILIKKI
KKEKTSKDYILPITLLPGASI
>M6_Spy1076 Cytosolic protein containing multiple CBS domains
MIIIMSKHQDILDYLEKLAIGKKVSVRSISNHLKVSDGTAYRAIKEAENR
GIVETKPRSGTVRIEKKGRVRIDRLTYSEIARISDSEVLAGHAGLGHEFS
RFSIGAMTQQNIRRYLVKGGLLIVGDRETIQLLALENHNAILVTGGFPVS
KRVIEMANNQRIPVMVTHYDTFTVATMINHALSNIRIKTDLKTVEQVMIP
ITDYGYLCENSSVEEFNTLIKKTRQVRFPVLDYKRKVIGVVSMRDVVDQL
PTTKLTKVMSKNPITARPNTSLANISQKMIFEDLNMLPVTDEENNLLGMI
TRRQAMENLPNHQPNNPYTYSEQILSNLEETVDYYQVVVEPTMIDSAGNM
SNGVISEFLKEISIRALTKKHQKNIIIEQMMVYFLHAIQIEDELKIYPKI
ITENRRSSTIDIEIFVDDQVIAKAIITTKIN
>M6_Spy1846 Transcriptional regulator, PadR family
MYFPVSATLIEFLILAIVEKNDSYGYDISQTIKLVANIKESTLYPILKKL
EKAGFLTTYSQEHQGRKRKYYAVTSSGRAQLIFLKKEWQSYKFALDGIIE
GSLRHDKD
>M6_Spy0119 DNA-directed RNA polymerase alpha chain
MIEFEKPIITKIDENKDYGRFVIEPLERGYGTTLGNSLRRVLLSSLPGAA
VTSIKIDGVLHEFDTIPGVREDVMQIILNVKGLAVKSYVEDEKIIELEVE
GPAEVTAGDILTDSDIELVNPDHYLFTIAEGHSLRATMTVAKKRGYVPAE
GNKKDDAPVGTLAVDSIYTPVKKVNYQVEPARVGSNDGFDKLTIEIMTNG
TIIPEDALGLSARVLIEHLNLFTDLTEVAKATEVMKETEKVNDEKVLDRT
IEELDLSVRSYNCLKRAGINTVFDLTEKSEPEMMKVRNLGRKSLEEVKVK
LADLGLGLKNDK
>M6_Spy0970 Transcriptional regulator, DeoR family
MVYDDIMLLTKREEQLLKALLNYGKLSIDNMGDILKVSRRTVYRVLNELT
DSLESLNISIIKEDQKYYLTGELEELRAFSSQDNFSKNERLNLITYYLLI
ANQEITNEFLQEKLAVSNVTIIQDIAIVEKRLADFNILLIFSNDGYQIHQ
IN
>M6_Spy0679 Fructose repressor
MAKITEENYVSLEDLMQLLNSSESTIRRDLGELEQEGRLHRVHGGAELFH
SLQEELSNQEKSVKNSHIKKTIAQRASQFIYDNDVIFIDAGTTTEFLLPF
LQAKNLTVVTNSIHHAARLVELSIETIIVGGYVKQTTDASIGNVALEQIR
QMNFDKAFLGMNGIDDSYLTTPDMEEAVIKKAVLSNAKLAYILVDGTKIG
QVSFVKVAPINDVTIITLGGSASILKQIKEKAKVIEL
>M6_Spy1494 Heat-inducible transcription repressor
MITQRQNDILNLIVELFTQTHEPVGSKALQRTIDSSSATIRNDMAKLEKL
GLLEKAHTSSGRMPSPAGFKYFVEHSLRLDSIDEQDIYHVIKTFDFEAFK
LEDMLQKASHILAEMTGYTSVILDVEPARQRLTGFDVVQLSNHDALAVMT
LDESKPVTVQFAIPRNFLTRDLIAFKAIVEERLLDSSVIDIHYKLRTEIP
QIVQKYFVTTDNVLQLFDYVFSELFLETVFVAGKVNSLTYSDLSTYQFLD
NEQQVAISLRQSLKEGEMASVQVADSQEAALADVSVLTHKFLIPYRGFGL
LSLIGPIDMDYRRSVSLVNIIGKVLAAKLGDYYRYLNSNHYEVH
>M6_Spy1592 Transcriptional regulator, MerR family
MGFSIEQIRKVLAEENAAQVLELLLVDHIATAKEDLAAKEQQVDIAVKIL
DRLRKQDPQSLDFLMDISLSMKNQKAWKKLQWKMGISIFLAIVSYVGLIL
LSNYLQKFWLVYVAMGLFLPGFSWLVIYFRKQFIYLCPHCHQKFEPSFNE
FALAGHTPRTRKLTCSHCHQKSYCLELAKEDTVSRG
>M6_Spy1656 Transcriptional regulator, Cro/CI family
MKNLKLKAARAGKDLSQQALADLVGVSRQTIAAVEKGDYNPTINLCIAIC
RVLDKTLDDLFWEADDSR
>M6_Spy1460 N utilization substance protein A
MPSFTSKVDNIMSKEMLEAFRILEEEKHIDKADIIDAVTESLKSAYKRRY
GQSESCVIEFNEKTADFQVFTVREVVEEVFDSRLEISLKDALAISSAYEL
GDKIRFEESVNEFGRVAAQSAKQTIMEKMRRQMREVMFNEYKEHEGEIMT
GTVERFDQRFIYVNLGSLEAQLSHQDQIPGETFKSHDRIDVYVYKVENNP
KGVNVFVSRSHPEFIKRIMEQEIPEVFDGTVEIMSVSREAGDRTKVAVRS
HNPNVDAIGTIVGRGGSNIKKVISKFHPKRVDAKTGLEIPVEENIDVIQW
VDDPAEFIYNAIAPAEVDMVLFDDEDLKRATVVVPDSKLSLAIGRRGQNV
RLAAHLTGYRIDIKSASEYDRLEAEKEAATVVEEPVVDDVMTAEEV
>M6_Spy1249 Arginine repressor
MLPRHIRSLRNMKKSERLELIKKMVLTHPIETQHDLLRLLAEHGLELTQA
TISRDMNEIGIVKIPSGSGRYIYGLSQDSGKKIVQGPRSIKSTILAVSDK
TKGLEQHLYLKVVPGNSKLIKRYLLADFSKAIFSLIADDDSLLLIAKSPS
EADMIRQEILLWMQGIT
>M6_Spy0888 Transcriptional regulator, GntR family
MNPIIEAVKQNLDLSRNIPLKIAFYNALKKTIILRQIPVGSRINEKEFSI
ALNISRTPIRYALGLLSEEHLVEHIPKKGIIVKGVSIKDACEIFEIRKAL
ETLATVQAMHLMTEEDFKVMHNLLEDCETFIAEDDTNRILDNFNAFNNLI
YSYSQMVRLKEIVTELQAYLVYFRKISISSVERRKRALSEHWMIYRGMKN
KDHEQITLITHEHLNSSLEFILKEMRPEQND
>M6_Spy1505 Transcription pleiotropic repressor
MQKRVSFVIMKAQIIQRKRKKMPNLLEKTRKITSILQRSVDSLETELPYN
TMASRLADIIDCNACIINGGGTLLGYAMKYKTNTDRVEEFFEAKQFPDTY
VKAASRVYDTEANLSVENELTIFPVESKDTYPGGLTTIAPIYGGGMRLGS
LIIWRNDNEFSDDDLILVEISSTVVGIQLLNLQTENLEDTIRKQTAVNMA
INTLSYSEMKAVAAILGELDGNEGRLTASVIADRIGITRSVIVNALRKLE
SAGIIESRSLGMKGTYLKVINEGIFAKLKEF
>M6_Spy0506 stress-responsive transcriptional regulator
METKFYKQRKNRLVAGVIAGLADKYGWDLALARVLAALLIYGTGFGVLLY
ILLAIFLPYKEDLLEERYGRGPRRRKDADVLNEEEDGWFW
>M6_Spy0556 ATP-dependent helicase, DinG family
MFCFIDIACYNRLTMTQKKLRKYAVVDLEATGAGPNASIIQVGIVIIQGN
KIIDSYETDVNPHESLDEHIVHLTGITDKQLAKAPDFGQVAHHIYQLIED
CIFVAHNVKFDANLLAEALFLEGYELTIPRVDTVELAQLFFPRFEKYNLS
HLSRQLNIDLAEAHTAIADARATAILFLRLLQKIESLPIECLESLLVYSD
SLLFETAMVIQEGLAKAKPYDPNKYIKIRQILLPKGSKALKPYQISKSFP
INMALLGLEERPKQTQFAQLIDEDYHQGVASFIEAQTGIGKTYGYLLPLL
AKEDQNQIIVSVPTKLLQDQLMAGEVAAIQEQFHIACHSLKGPANYLKLD
SFADSLDQNDQNRLVNRYKMQLLVWLLETKTGDLDEIKQKQRFAAYFEQL
KHDGDIKQSSEFYDYDFWRVSYEKAKTARLLITNHAYFLHRVQDDKDFTR
NKVLVFDEAQKLMLQLDQLSRHQLNLTVFLQTIQAKLSNPLPLLEKRLLE
SLSFELGQVSSDYYQNKEHQLAHDWSRIAGYAKELTGADYQELQAFFATS
DGDYWLSSEKQEEKRVTYLNSASKAFIHFQQLLPETVKTYFVSATLTISS
EVTLADLLGFEEYLYHVIEKDKKQDQLVLVDQEAPIVTEVSDQIYVEAIA
KRIESLKQEGYPILVLFNSKKHLLLVSDYLDQWQVSHLAQEKNGTAYNIK
KRFDQGEQTILLGLGSFWEGVDFIQADRMITLIARLPFDNPEDFFVKKMS
HYLLEKGKNPFRDYFLPMTILRLKQAIGRTMRRQDQKSVVIILDRRLLTK
SYGQVILEGLGQEFLISQQNFHDCLVETDCFLI
>M6_Spy0504 transcription accessory protein
MENNNNHNIAEALSVSLHQIEQVLALTAQGNTIPFIARYRKEVTGNLDEV
VIKSIIDMDKSLTTLNERKATILAKIEEQGKLTDQLRTSIEATEKLADLE
ELYLPYKEKRRTKATIAREAGLFPLARLILQNAQNLETAAEPFVTEGFAS
PQEALAGAVDILVEAMSEDAKLRSWTYNEIWQYSRLVSTLKDEQLDEKKV
FQIYYDFSDQVSNMQGYRTLALNRGEKLGILKVSFEHNLEKMQRFFSVRF
KETNPYIEEVINQTIKKKIVPAMERRVRSELSDAAEDGAIHIFSENLRHL
LLVSPLKGKMVLGFDPAFRTGAKLAIVDQTGKLLTTQVIYPVAPASQTKI
QAAKETLTQLIETYQIDIIAIGNGTASRESEAFVADVLKDFPNTSYVIVN
ESGASVYSASELARHEFPDLTVEKRSAISIARRLQDPLAELVKIDPKSIG
VGQYQHDVSQKKLSENLGFVVDTVVNQVGVNVNTASPSLLAHVSGLNKTI
SENIVKYREENGALTSRADIKKVPRLGAKAFEQAAGFLRIPGAKNILDNT
GVHPESYPAVKELFKVLDIQDLDDAAKATLAAVQVPQMAETLAIGQETLK
DIIADLLKPGRDLRDDFEAPILRQDILDLKDLEIGQKLEGTVRNVVDFGA
FVDIGVHEDGLIHISEMSKTFVNHPSQVVSVGDLVTVWVSKIDLDRHKVN
LSLLPPRDTH
>M6_Spy0131 DNA-directed RNA polymerase beta chain
MAGHEVRYGKHRTRRSFSRIKEVLDLPNLIEIQTDSFQDFLDSGLKEVFE
DVLPISNFTDTMELEFVGYEFKEPKYTLEEARIHDASYSAPIFVTFRLVN
KETGEIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKV
DKNGKVGYGSTVIPNRGAWLELETDSKDIAYTRIDRTRKIPFTTLVRALG
FSGDDEIVDIFGESDLVRNTIEKDIHKNPSDSRTDEALKEIYERLRPGEP
KTADSSRSLLIARFFDARRYDLAAVGRYKVNKKLNIKTRLLNQIIAENLV
DAETGEILVEAGTEMTRSVIESIEEHLDGDLNKFVYTPNDYAVVTEPVVL
QKFKVVSPIDPDRVVTIVGNANPDDKVRALTPADILAEMSYFLNLAEGLG
KVDDIDHLGNRRIRAVGELLANQFRIGLARMERNVRERMSVQDNDVLTPQ
QIINIRPVTAAVKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTR
DRAGYEVRDVHYTHYGRMCPIETPEGPNIGLINNLSSFGHLNKYGFIQTP
YRKVDRATGRVTNEIVWLTADEEDEYTVAQANSKLNEDGTFAEEIVMGRH
QGNNQEFSASVVDFVDVSPKQVVAVATACIPFLENDDSNRALMGANMQRQ
AVPLIDPKAPYVGTGMEYQAAHDSGAAVIAQHNGKVVFSDAEKVEIRRQD
GSLDVYHITKFRRSNSGTAYNQRTLVKVGDIVEKGDFIADGPSMENGEMA
LGQNPVVAYMTWEGYNFEDAVIMSERLVKEDVYTSVHLEEFESETRDTKL
GPEEITREIPNVGEEALKDLDEMGIIRIGAEVKEGDILVGKVTPKGEKDL
SAEERLLHAIFGDKSREVRDTSLRVPHGGDGIVRDVKIFTRANGDELQSG
VNMLVRVYIAQKRKIKVGDKMAGRHGNKGVVSRIVPVEDMPYLPDGTPVD
IMLNPLGVPSRMNIGQVMELHLGMAARNLGIHIATPVFDGASSEDLWDTV
REAGMDSDAKTVLYDGRTGEPFDNRVSVGVMYMIKLHHMVDDKLHARSVG
PYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNVLQEILTYKSDDVT
GRLKAYEAITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDNEVEL
RDLDEGEDDDIMHVDDLEKAREKQAQETQEVSETTDEK
>M6_Spy0321 Transcription elongation factor
MFVFLIRSKKKREKTIMAEKTYPMTLTEKEQLEKELEELKLVRRPEIVER
IKIARSYGDLSENSEYDAAKDEQAFVEGQISTLETKIRYAEIIDSDAVAK
DEVAIGKTVIVQEVGTTDKDTYHIVGAAGADIFSGKISNESPIAQALIGK
KTGDKVRIESPAATYDVEIISVEKTN
>M6_Spy0451 Catabolite control protein A
MNTDDTITIYDVAREAGVSMATVSRVVNGNKNVKENTRKKVLEVIDRLDY
RPNAVARGLASKKTTTVGVVIPNIANSYFSILAKGIDDIAAMYKYNIVLA
SSDEDDDKEVNVVNTLFAKQVDGIIFMGHHLTEKIRAEFSRSRTPVVLAG
TVDLDHQLPSVNIDYRAAVSNVVDILAENHKCIAFVSGPLIDDINGKVRL
AGYKEGLKHNKLDFKEGLVFEANYSYKEGFELAQRVINSGATAAYVAEDE
LAAGLLNGLFEAGKRVPEDFEIITSNDSPVVQYTRPNLSSISQPVYDLGA
VSMRMLTKIMNKEELEEKEILLNHGIKKRGTTK
>M6_Spy0237 FasA
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQE
RGDHQLYFLDIEIGEYTRCGLELAAAIRQKDPNAVIVFVTTHSEFAPISF
KYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQT
RLKLPYKDILYFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCH
RSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFERWEALR
>M6_Spy1748 Transcriptional regulator, DeoR family
MMNRLERIIQLVSQKKKIDVNSLSEQLEVSKVTIRKDLDKLESKGLLRRE
HGYAVLNSGDDLNVRLSYNYNIKRRIAEKAAELVQDNDTIMIESGSTCAL
LAEVLCQNKRNIKVITNSCFIANYIRQYSSCQIILLGGYYQPNSEVTVGP
LLKEMISLFHVNRVFVGTDGFNKDLGFMGKDMMRSEGVRYMADAAEEVVI
LTDSSKFSKTSLVHQLSLADVNRVITDQALDKQTQELLSASGLVLDFVS
>M6_Spy1106 Transcriptional regulator, Cro/CI family
MKEMAMEVILKNRLKELRARDGINQTEMAKLAGVSRQTISLIERNEYTPS
VIIAMKIAKVFQEPVEEVFRLVEVEE
>M6_Spy0564 Transcriptional regulator, GntR family
MNKMPKEQPLYLQIVDDLEVKIKKSMTANDKLLSERELSDLYGVSHITIR
LALKELELRGLIYKKQGKGTYVSGIKEPATDLSSTYSFTEQMKKMGKMPK
TEFLSFEQYQVTPYLSGLLEIDVDTDVFELERLRIADDMPLMFERSYIPA
QPFQGLSIADLKRKALYDIFAKDYQETIRLAEEEFYASIALDYEAGLLGI
KKGDPVLHIIRKTYDDKNILIELTFSIARADQFRYRVQHHPNG
>M6_Spy1441 Transcriptional regulator, TetR family
MMTDKALSKRSLQNLTQFNKETRRIARESMEIALLNLLETKPLGDITISE
LVTKAGVSRNAFYRNYTSKEAIIEQLLVGVIRRIFRGLKQFDIKTQAYQA
WLYLFTEAKKEAQLLKMIFKHHLHHLLTRLVTKRLKAYQKLKDKKQSHYK
RLFWSNAIVSVLTNWISDDMIVPAEEMAAMGLPLLT
>M6_Spy1018 unknown phage protein
MKKKLDKILIDKGMSKKELSEKTGISYNTIMNIGKKDISFNKMKKIADDL
GVSLDEFR
>M6_Spy0083 Transcriptional regulator
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKV
IFIAKALNVSVGYLTDGADLELPKRYKELKYLILRTPTYMDDGKLQVREE
QFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQI
KTKVRFRQNDLILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQF
ELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMAKIQDWNRMPI
LKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDV
KSY
>M6_Spy0718 Transcriptional regulators, LysR family
MRIQQLHYIIKIVECGSMNEAAKQLFITQPSLSNAVKDLEMEMGITIFNR
NPKGITLTKDGVEFLSYARQIIEQTSLLEDRYKNHNTGRELFSVSSQHYA
FVVNAFVSLLKRTDMTRYELFLRETRTWEIIDDVKNFRSEIGVLFINDYN
RDVLTKLFDDNHLTASPLFKAQPHIFVSKSNPLATKSLLSMDDLRDFPYL
SYDQGIHNSFYFSEEMMSQMPHNKSIVVSDRATLFNLMIGLDGYTVASGI
LNSNLNGDQIVAIPLDVPDEIDIVFIKHEKANLSKMGERFIEYLLEEVTF
D
>M6_Spy1489 Transcriptional regulator, MarR family
MTVKVLLLGGICLEYDKINHYLVDIFNRILVIEEMSLKTSQFNDVSLKEM
HTIEIIGKYDQVTPSDIARELMVTLGTVTTSLNKLEAKGYIARTRSRSDR
RVVYLSLTKRGRLLDRLHAKFHKNMVGHVIADMSDEEMQALVRGLGNLHQ
FLEDLV
>M6_Spy0903 Phage transcriptional repressor
MFSGHQLKTARLSKGITQSELGGLLHVNKMTISNWEKGKNIPNEKHLNAL
LHLFNVTSDYFDPNYKLLTPYNQLTISNKEKVIGYSERLLNHQIDKKSKD
LIDKPSQLYAYRVYESLSAGTGYSYFGDGNFDVVFYDEQLEYDFASWVFG
DSMEPTYLNGEVVLIKQNSFDYDGAIYAVEWDGQTYIKKVFREDEGLRLV
SLNKKYSDKFAPYSEEPRIIGKIIANFRPLEI
>M6_Spy1512 ATP-dependent DNA helicase
MILTAPMSNLKGFGPKSAEKFQKLDIYTVEDLLLYYPFRYEDFKSKSVFD
LVDGEKAVITGLVVTPANVQYYGFKRNRLSFKLRQGEAVLNVSFFNQPYL
ADKIELGQEVAVFGKWDATKSAITGMKVLAQVEDDMQPVYRVAQGISQST
LIKAIKSAFEIDAHLELKENLPATLLEKYRLMGRSQACLAMHFPKDITEY
KQALRRIKFEELFYFQMNLQVLKAENRSETNGLPILYSKHAMETKISSLP
FILTNAQKRSLDDILSDMSSGAHMNRLLQGDVGSGKTVIASLSMYAAYTA
GFQSALMVPTEILAEQHYISLQELFPDLSIAILTSGMKAAVKRTVLAAIA
NGSVDMIVGTHALIQDSVQYHKLGLVITDEQHRFGVKQRRIFREKGENPD
VLMMTATPIPRTLAITAFGEMDVSVIDELPAGRKPIMTRWVKHEQLGTVL
EWVKGELQKDAQVYVISPLIEESEALDLKNAVALHAELSTYFEGIAKVAL
VHGRMKNDEKDAIMQDFKDKKSHILVSTTVIEVGVNVPNATIMIIMDADR
FGLSQLHQLRGRVGRGHKQSYAVLVANPKTDSGKKRMTIMTETTDGFVLA
ESDLKMRGSGEIFGTRQSGIPEFQVADIVEDYPILEEARKVSAAIVSDPN
WIYEKQWQLVAKNIRKKEVYD
>M6_Spy1389 Transcriptional regulators, LysR family
MIDLAIAIKNHLCHNGINTIGKKTNRQGDNHLDIKQIRYFIAIVENHFNL
SQAAELLYVSQPTLSMMINDFEKRENVKLFKRKRGRIIGLTYLGDNYYKD
AQKVLGLYDDMFLKLHDHSKGLKGSINIGIPPLILSVVFSEVMPKLILEN
PGIQFNVKEIGAYQLKNELLVGNVDVAVLLSPTGIADNLVETYEIQRSEL
SVCLSPRHRLASKKVIQWEDLTDEQLALFDPSFMVHHLVLEACERHQVRP
NIILTSSSWDFMLNSTKINHNVLTICPKPITELYQLKDIKCIPMERPISW
RVVLTRLRKKSYSEIEAYIMDDLLQSFFK
>M6_Spy1850 Transcriptional regulator, TetR family
MVNRKENTKQAILKAMVMLLKTESFDDITTVKLSKRAGISRSSFYTHYKD
KYEMIDYYQQTFFHKLEYIFEKKYQNKEQAFLEVFEFLQREQLLSSLLSA
NGTKEIQAFIINKVRLLITTDLQDKFSTEELSQTEKEYQSIYLAHAFFGV
CQSWIAKGKKESPQEMTQFVLKMLTST
>M6_Spy1590 Transcriptional regulator
MSAKKTFFASNLKYLRLKKNMEQLELANLLGRKSSSSISEWEKGNILQSL
VY
>M6_Spy0737 Phage transcriptional repressor
MYLKVFFCILLKNIVFIPLEVYNIVRHIIVKEQKMANLSDNIKYFRKQNK
LTQKELAKKLKIAPTAISAWEVGRNKPLMDNIEQMTSIFGIPKSKLLGDE
IYKIQETASPELIPSTLQKITATSSQLEHSRQLIVLDTAETLLNQQKEIK
NNEDTVVELFSYNYYDQPASAGTGQYLNDVQVETIELPVDYDADFVIPVY
GDSMGPEYHSEDYVFVKLSVDLSDGDIGVFEYYGDAYIKQLLINAEGAFL
HSFNSKYDDIPIDRDSDFRIIGEVIGSYSEK
>M6_Spy0201 Transcription antiterminator, BglG family
MMILDKKSYDLLSYLLKLETPETVMAISHALNQSRRKVYYQLDKINQALP
KGVDQIISYPRLGILLTADQKAACRLLLEEVTDYNYVMKSDERRRLSSIY
IAVSTERVTIDKLMQINDVSRNTILNDLTELREELEDKQYKIQLHATKAR
GYYFGCHPMALIQYLYKLLVDVYQGGNTSFIDIFNRKLSEIQGLSVYFSK
DILTYFHEYLFLSQASLGKTINTQDSQFMLQILPFMLLSYRNMRLDSETK
SALKQEFHLIWKRKEYHIAQDLARELYHNFKLHLDDIEVSMVAMLMLSFR
KDQDHHVESQDYDDMRATISHFIDQLESRYQLHFTHKQDLLKQLTTHCKA
LVYRKAYGIFLVNPLTDHIKEKYEELFAMTQSCATILEQDWTISLTDDDI
AYLTIHLGGELRHNNTEQEKTKLVIVSDDGIGIQKLLFKQCQRYLANGQI
EAVFTTEQYQSVYDLLAVDMIVATTDTLKTKIPMLIVNPILSDDDIIKLI
RFSKQGRLSEHSRFSTELTKAIEAVVKDESDRYALVSKIEKLIHRELL
>M6_Spy1468 Transcriptional regulator, LytR family
MKIGKKIVLMFTAIVLTTVLALGVYLTSAYTFSTGELSKTFKDFSTSSKK
SDAIKQTRAFSILLMGVDTGSSERASKWEGNSDSMILVTVNPKTKKTTMT
SLERDTLTTLSGPKNNEMNGVEAKLNAAYAAGGAQMAIMTVQDLLNITID
NYVQINMQGLIDLVNAVGGITVTNEFDFPISIAENEPEYQATVAPGTHKI
NGEQALVYARMRYDDPEGDYGRQKRQREVIQKVLKKILALDSISSYRKIL
SAVSSNMQTNIEISSRTIPSLLGYRDALRTIKTYQLKGEDATLSDGGSYQ
IVTSNHLLEIQNRIRTELGLHKVSQLKTNATVYENLYGSTKSQTVNNNYD
SSGQAPSYSDSHSSYANYSSGVDTGSSYQSTSTDQDSTASSHTPTTPSSS
SDALAADESSSSGSGSLVPPANINPQT
>M6_Spy1031 Transcriptional regulator, LacI family
MYNGNEIHDKPMIRFIFGKYSNEVNMVTIKDVAQKAGVNPSTVSRVLKDN
RSISMKTKEKVRKAMADLGYVPNVAAQILASGLTHNIGLVFPPITTSDRL
SEPFFMEILSTITNEAKESHFTVSIATGISLVDLIEQVKLMHLQKRVDGF
IILYSDQDDPVKKYLMTNNLPFVIVGAPQGDTNKTTYIDNDNQLMAKTAV
EHLYQKGHHNILFITDDLLSEVTSERYLGYLKGCFKRSLKTKPMLLFDRK
DPVSVEILMETISSFKATALVVVGDVLAIRMVQLLSFYDIKVPDDMSIIT
FNNSNYAKLIHPYLTTFDINVENLGKMSFKQLLDIINSNEQNLSQTIFVP
FSLKQRESVRDISH
>M6_Spy0498 Transcription antiterminator, BglG family
MLIKRVLNHNSAISTNHQGLDILLMGKGIAFGKKVGDSIELNAIETSFVL
KNSDNMNRFTELFITVPQEVVACSERIINLGKIKLGKTLDEILYINLTDH
IHSAIERHEQGMLIHNPLRWEIQRYYPDEYSLGVKALELIERNLGVTLAI
DEAAFIAMHFVNASLDTPFKEPHRLTEIVSYIEQKIKTDFKTELDDTSID
YYRFMTHIKLFAQRVLSEMSYDDDDAELLLVVKTKYPKEYRCVLDISEEI
KKRYNYHLNSSELLYLTVHVKRLVKHLKET
>M6_Spy1679 Transcriptional regulator, MarR family
MTYRIKRGNQMSHLDKNTALKAMVVFRKAQRTLDAFGADIFKKADLTATQ
FSVLEVLYTKGCMRINHLIDSLLATSGNMTVVLNNMERNGWISKCKDKTD
KRAYVVTLTDKGTRLIEAVLPKHVARVEEAFAVLTEKEQLCLIELLKKFK
QL
>M6_Spy0335 ScpB
MTYLSQIEALLFVAGEEGLSLRHLASMLSLTPTALQQQLEKLSQKYEKDQ
HSSLCLIETANTYRLVTKEGFAELLRAYAKTPMNQSLSRASLEVLSIVAY
KQPITRIEIDDIRGVNSSGALSKLLAFDLIREAGKKDVVGRPHLYATTDY
FLDYMGINHLDELIEVSAVEPADEEIALFRTQD
>M6_Spy1411 ATP-dependent RNA helicase
MSFKDYHFKQYVQQALEEIGFVNPTEVQQRLIPIVNSGRDLVGESKTGSG
KTHTFLLPIFEKLDEAKAEVQVVITAPSRELATQIFDACKQIAKHSQEEI
RLANYVGGTDKLRQIEKLKGSQPHIVIGTPGRIYDLVKSGDLAIHKATTF
VVDEADMTMDMGFLDTVDKIAASLPKSVQILVFSATIPQKLQPFLKKYLT
NPVIEQIKTKTVIADTIDNWLVSTKGRDKNGQLLEILKTMQPYMAMLFVN
TKERADDLHAFLTANGLKVAKIHGGIPPRERKRIMNQVKKLDFEYIVATD
LAARGIDIEGVSHVINDAIPQDLSFFVHRVGRTGRNGMAGTAITLYQPSD
DSDIKELEKMGIAFTPKVLKNGEFQDTYDRDRRQNREKAYQKLDTEMIGL
VKKKKKKVKPGYKKKIQWAVDEKRRKERRAENRAKGRAERKAKKQHF
>M6_Spy0391 Iron-dependent repressor
MTPNKEDYLKCIYEIGEQETKITNKMVAEKMHVSAPAVSEMIKKMISQGW
IVKDKAKGYLLKDKGYALVANLYRKHRLIEVFLIHQLGYNTQEVHQEAEV
LEHTVSDTFIDRLDKILDFPDFCPHGGTIPRYGQPLVEMNTTTLNTITEL
GRFRLSRIHDHFDLIQYLETHHLNINTELTLTQIDTFAKTYTICYGDKEL
VIPENIAKQLYVTAL
>M6_Spy1600 Transcriptional regulator, GntR family
MSTNDLTKKLKKLKHVQVYNTIFQLIQDGTYSPGMQLPSEPELARQLNVS
RMTLRKSLALLQEDHLIKNIRGKGNFILKTPETKYHQGFEYLQHPIYASL
SSDITKVELEYRIEVPTVAITASLKQETPVVIIVDRWYHSQNKAIAYSLS
FIPIEVISKYAINLNQEEPLLTFLEEKIYDSGKASHSCNQIGYTKTGNYT
ATKYTLSENSAFILIQETLYNGKDILVSTKHYVPADLFDLKVQSQSCQSD
TH
>M6_Spy1534 N utilization substance protein B
MMRISWMTNSFQNSRRDLRERAFQALFNIETGAELLAASQFAYGYDKVTG
EDAQVLELPIFLLSLVTGVNNHKEELDNLISTHLKKGWSLERLTLTDKTL
LRLGLFEIKYFDETPDRVALNEIIEVAKKYSDETSAKFINGLLSQYVSEA
PSANKS
>M6_Spy1285 Ribose operon repressor
MLGNISDSEALEEEYVHVLLQSNAAGIITTHDFTKRYPTLAIPVVVVDRV
DQETQYGVFSDNRAGGLLAAQTVWQAGAKEVLLIRGPLDNAENINERFEA
SFSYLQKQDVTMYVCDSQNFDFENIQLEASSNLKCYPTIDSIIAPSDIHA
IAYIHELHSQGKKFPQDVQIIGYDDILMSQFIYPSLSTIHQSSYLMGRYA
AELVYTIASQLTVKANRIKLPVHYVERETIRKR
>M6_Spy0165 Transcriptional regulators, LysR family
MNISSLAYFIEIVNCDFNLTKAAQKSHISQPALSSYIKTIEKEEGVVLFQ
RQKGRLVGLTSVGERFFENAKVVIASHEQLMADLRSESKKYKGEISIGIP
QLISGIVFSELIPKLIEENPEVKFHIVETGAYELQKKTVSKRSRFCDFIN
THYTRCYYC
>M6_Spy1841 Transcriptional regulator
MLSKSLQVPLEQLIAEDIPKMTLIIKDEEIKQCDRNTHIMLFGTLLIAIS
IYPIMSWLGWWGYGPVAILWLIIMRSALRIERFKKTYDVQTYR
>M6_Spy0957 Transcriptional regulator, TetR family
MTKRHTETKAYVKTALITLLTEQSFETLTVSDLTKKAGINRGTFYLHYTD
KFDMMNHFKNDTLDDLYRLLNQAEIYTDTRQVLNQTLSYLIEHREFITAL
ATISYLKFPQLIKDFCYQFLTTITGFQDIVTNQYHIPYPYALEVYLASIE
SIISYWIANGYQETTEEVADIILKAVTLDN
>M6_Spy0862 Phosphinothricin N-acetyltransferase
MLRPLSKTDCPMLQEINAKALGYLVSLDLLERQYERLIEDCHHYFLAYAD
KDTNQLLGYVHAERYETLYASDGLNLLGLAVLPAYQRRGIGSALLRALES
QAKQEGIAFIRLNSASHRKEAHAFYQNLDYADDKTQLRFIKNLQGDDNDF
>M6_Spy1161 Phage transcriptional repressor
MFSHGRLKQRRLEIKLSQTAIANQLNVHRSAYHNWENGRNTPNQKNLTAL
AAILDVPVTYFESEYNIVNNYLQLSPDNQLKAEEYVEELLLSQQTSNVIP
LFSVQVLSDIQLSAGLGEGFFDEFETETIYSDEEQYGYDIAAWIEGDSME
PVYKSGEVALIRSNGFDYDGAVYALSWNDSVYIKKLYRDEDGFRMVSLNK
DYPEKFIPYEDEPRIVGLVVGHFMPVEGV
>M6_Spy1295 Acetyltransferase
MTDKFDANDETRTVYAVVYDNDQPVSTGQFLAETKIEARLTRIVTLADYC
GCGYGAKVTEALETYTRREGFYQLTIHSELTAQTFYENLGYQTYGSKYLE
DGEYCQSLVKTILKWEKNMDIAMLIAIVGGLLGCYLYLTKNNEPKD
>M6_Spy1694 GTP pyrophosphokinase
MRNEMAKIMNVTGEEVIALAATYMTKTDVAFVAKALAYATAAHFYQVRKS
GEPYIVHPIQVAGILADLHLDAVTVACGFLHDVVEDTDITLDEIEADFGH
DARDIVDGVTKLGKVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRL
HNMRTLKHLRKDKQERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLN
ETEFYKISHMMKEKRREREALVEAIVSKVKTYTTQQGLFGDVYGRPKHIY
SIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRF
KDYIAAPKANGYQSIHTTVYGPKGPIEIQIRTKDMHQVAEYGVAAHWAYK
KGVRGKINQAEQAVGMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIY
VFTPTGAVQELPKESGPIDFAYAIHTQIGEKATGAKVNGRMVPLTAKLKT
GDVVEIITNANSFGPSRDWVKLVKTNKARNKIRQFFKNQDKELSVNKGRD
LLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFGDISPIS
VFNKLTEKERREEERAKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQ
GASGLLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHNIKSQDGYQER
LIEVEWDLDNSSKDYQAEIDIYGLNRSGLLNDVLQILSNSTKSISTVNAQ
PTKDMKFANIHVSFGIPNLTHLTTVVEKIKAVPDVYSVKRTNG
>M6_Spy1286 Ribose operon repressor
MKNPHKLILQGGKAMVTIKQVAEEAGVSRSTVSRYISQKGYVSDDARHKI
KAAIAKLHYTPNVLAQSLKTKKIN
>M6_Spy1149 Phage-related DNA helicase
MKLTLHNYQVVAKDFIIGHPYAAVILDMGMGKTATTLSAVNELMFDRFEV
TKVLVIAPLRVANTVWSDEIEQWSELRNLRYSKIVGTPKQRKVALQKDAD
IYIVNRENLPWLVEQCSPYFKWDMVVIDELSSFKSWQSKRFKAFMTMRPY
MKRVVGLTGTPSSNGLMDLFAEFKVIDGGERLGRFIGEFRSRYFEEGRRN
GNIVYEYIPMDYAECQIQDKISDITISMKALDYLDMPELISTKKLVRMSE
KEKEKYIQFKKEYVLSELDGLEVTAANAASLMNKLVQLSNGAVYSDDHTV
VPLHEQKLDALEDILESANGEPVLVAYWFKHDLARITGRLEKLKVTSRVL
KTEEDIREWNKGNVPVGLIHPAGAGHGLNLQKGGHHLVWFGLTWSLELYQ
QTNARLWRQGQEAETVVIQHIVTEGTIDEEILKALGNKDAQQERLIEAVK
AQVGGTDG
>M6_Spy1091 ATP-dependent RNA helicase
MNIETIVKGRRMITKFPPQWQEKLDQVAFTHLTPIQEQAFQPIVDGKNFL
GISPTGTGKTLAYVFPSLLALTPKKSQQLLILAPNTELAGQIFEVTKDWA
QSLGLTAQLFISGTSQKRQIERLKKGPEILIGTPGRIFELIKLKKIKMMS
VNTIVLDEYDELLGDSQYDFVQKISHYVPRDHQMVYMSATNKVDQTSLAP
NTFCIDLSEQTNDAIQHFYLMVDKRERTDLLRKFANIPHFRALVFFNSLS
DLGATEERLQYNGAAAVSLASDINVKFRKTILEKFKSHQLSLLLATDLVA
RGIDIDNLDYVIHFDVARDKENYTHRAGRTGRMGKSGIVITFVSHPEDLK
KLKKFAKVSEISLKNQQLHFIN
>M6_Spy1807 HTH DNA-binding protein
MKNNLRVILARQRKKISDVHEATGVSKTTLTALYYERTENPDSKTLLKIA
KCLNVTLDELLTVED
>M6_Spy1024 Phage transcriptional repressor
MARGRGKLTPQDEEYKKIISAKINSLLLENNLKQGHLADALEIPRSSFNE
YVKGNSLPNPGNVQKIADYFGLMKSDIDPRFAPRKKNHELKIPTSPLVKK
ITTTVVELNVPRKQKVLDFATEQLKEQKNKITSIEKKLYEYKVYEKLSAG
TGYGYFGDGNYDTVFYDEELDYDFASWVFGDSMEPTYVNGEVVLIKQTGF
DYEGGIYAVEWDGQTYIKKVYREKDGLRLVSLNKKYNDKFAPFSEGPRII
GEIVGNFMPKEY
>M6_Spy1806 Transcriptional regulator, Cro/CI family
MIKTNFAVLMAERGLKIADVYEDTGISKTTLMALSENTGKGVQFDTVDKL
CNYLGIELKDFFVYSPYIWKAYNKEDYEYKEEGDNLIAINLKSTHSERVY
ILKLFFFSPKHIDSPTDDTTVKLWVRLSLDEDSGNYGYNEFYDFISSLPI
SFQTHFYNDVIEVLKKHYLNSGAVISAYRYDFHPDKEYLSEIVLNKNDKV
IVSFFDSYGNSHAPKAIQIDKLIKVD
>M6_Spy1764 Cold shock protein
MYMAQGTVKWFNAEKGFGFISTENGQDVFAHFSAIQTSGFKTLEEGQKVA
FDVEEGQRGPQAVNITKLA
>M6_Spy0993 Hyaluronoglucosaminidase
MRLHKKKETDNKIAKLESIKADKDTVYLKAESKKELDKKMNLTGGTMTGQ
LQFKPNSHIKHSSSTGGAINIDMSKSAGAAMVMYTNKDTTDGPLMILRSD
KDTFDQSAQFVDYSGKTNAVNIVMRQPSTPNFSSALNITSANEGGSAMQI
RGIERALGTLKITHENPNVDAKYDENAAALSIDIVGKRGASGNGTAAQGI
FINSSAGTTGKMLRIRNKNKDKFYVNPDGGFHSYADSIVDGNLTVKDPTS
GKHAATKDYVDKKFDELKKLIQKTD
>M6_Spy1608 Transcriptional regulator, MerR family
MKEKELRRSMAVFPIGTVMTLTDLSARQIRYYEDQGLIKPERTQGNRRMF
SLNDMDRLLEIKDFLSEGLNIAAIKREYVERQGKLMQKQKALTDADVRRI
LHDEMLTQSGFSTPSQHIGNFRI
>M6_Spy1529 Fructokinase
MGKLYGSIEAGGTKFVCAVGDEEFTVVDKTQFPTTTPEETIARTIAYFKA
FEADLAGMTIGSFGPIDIDPSSETYGYITTTPKSGWANVDLLGQLSAAFK
IPFDVTTDVNSSAYGEVLARPGVESLVYYTIGTGIGAGAIQHGHFIGGLG
HTEAGHTYVMPHPDDMAKGFLGVCPFHKGCLEGMAAGPSIEARTGVRGER
LDQEADVWDIQAFYIAQAALQATMLYRPQVIVFGGGVMAQEHMVLRVHDK
FTTLLSGYLPVPDLTDYIVTPAVADNGSATLGNFALAKLAAQGK
>M6_Spy0766 Fibronectin-binding protein
MWYNEEIRIQKGETMSFDGFFLHHLTNELKENLLYGRIQKVNQPFERELV
LTIRNHRKNYKLLLSAHPVFGRLQITQADFQNPQVPNTFTMIMRKYLQGA
VIEQLEQIDNDRIIEIKVSNKNEIGDAIQATLIIEIMGKHSNIILVDRAE
NKIIESIKHVGFSQNSYRTILPGSTYIEPPKTAAVNPFTITDVPLFEILQ
TQELTVKSLQQHFQGLGRDTAKELAELLTTDRLKRFREFFARPTQANLTT
ASFAPVLFSDSHATFETLSDMLDHFYQDKAERDRINQQASDLIHRVQTEL
DKNRNKLSKQEAELLATENAELFRQKGELLTTYLSLVPNNQDSVILDNYY
TGEKIEIALDKALTPNQNAQRYFKKYQKLKEAVKHLSGLIADTKQSITYF
ESVDYNLSQASIDDIEDIREELYQAGFLKSRQRDKRHKRKKPEQYLASDG
KTILMVGRNNLQNEELTFKMAKKGELWFHAKDIPGSHVIIKDNLDPSDEV
KTDAAELAAYYSKARLSNLVQVDMIEAKKLHKPSGAKPGFVTYTGQKTLR
VTPDQAKILSMKLS
>M6_Spy0991 unknown phage protein
MQLTIKNKDLNTLYRVLDKIKITNMRANRGRAKLLAKVEGKLSEYAKDEV
DIIDQYVAKNDDGKWITDDKGNPKIEDTSKLAELNDFLDELASEPVVIKG
GEYSKRFIDFLEYLAESEDEFTSEEIIIIDNILEQFEESKGE
>M6_Spy0697 Two-component response regulator
MKILLAEDEWQMSNVLTTAMTHQGYDVDVVFNGQEAIDKAKDNAYDIMIL
DIMMPIKSGIEALKEIRASGNCSHIIMLTAMAEINDRVTGLDAGADDYLT
KPFSLKELLARLRSMERRVESFTPQVLQFAGVTLNINEQELSAGNAIRLA
SKEGKLMAFLMLNQGKYLDTKTLYQHVWSDQEDYDTSIVWVYISYLRQKL
LAIQANVIIAGDKDTSYCLLEK
>M6_Spy1378 Two-component response regulator yvqC
MTMSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALAL
KPDVLVMDLVMPELGGVEATLEVLKKWKEAKVLVLTSYLDNEKIYPVIDA
GAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEEL
TAREYDILHLLAKGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQA
VVYAFRHHLVPQDDN
>M6_Spy0673 Transcriptional regulator, TetR family
MSDMTKDRQIKKTKTAIYSAFLALLQKKEYSKITVRDMIALANVGRSTFY
AHYESKEMLLKELCEELFHHLFRQKRNVTFEDYLVHILKHFEQNKDSIAT
LLLSNDPYFLLRFKNELEHDVYPNLRCKYIDKTTIPEVFLKQFVLSSFIE
TLKWWLHQRQRMSANELLKYYLELIK
>M6_Spy1278 Glucokinase
MSQKLLGIDLGGTTIKFGILTAAGEVQEKWAIETNILEGGKHIVPDIVAS
IKHRLDLYGLSSADFVGIGMGSPGAVDRDTNTVTGAFNLNWKETQEVGSV
VEKELGIPFAIDNDANVAALGERWVGAGENNPDVVFMTLGTGVGGGIIAD
GNLIHGVAGAGGEIGHMIVEPENGFACTCGSHGCLETVASATGVVKVARL
LAEAYEGDSAIKAAIDNGEGVTSKDIFMAAEAGDSFADSVVEKVGYYLGL
ASANISNILNPDSVVIGGGVSAAGEFLRSRIEKYFVTFTFPQVRYSTKIK
IAELGNDAGIIGAASLARQFITK
>M6_Spy1785 Transcriptional regulator, MarR family
MLKKRPACPVETTLSVIRNKWKLLILRDLLKGTLRFGQLKSSIGSVSQKV
LTAQLRAMEAHREVYAEVPPRVEYSLTETGLSLAPVIEAMSDWDQTYQEK
HADLFEEG
>M6_Spy0125 Transcriptional regulator, MarR family
MGTLEKKLDNLVNTILLKAENQHELLFGACQSDVKLTNTQEHILMLLSQQ
RLTNTDLAKALNISQAAVTKAIKSLVKQDMLAGTKDTVDARVTYFELTEL
AKPIASEHTHHHDETLNVYNRLLQKFSAKELEIVDKFVTVFAEELEG
>M6_Spy1763 CtsR
MPTKNTSDSIEEYIKELLAKSGIAEIKRSMLADSFQVVPSQINYVIKTRF
TESRGYEVESKRGGGGYIRIAKVHFSDKHHLIGNLMATIEDCISEQVFTD
SIQLLFDEHLLTEREGNIILAVASDDVLGTDGSTIRARMLYRLLQRIDRK
GSN
>M6_Spy0310 Response regulator CsrR
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLI
LLDLMLPEMDGFEVTRRLQTEKTTYIMMMTARDSIMDVVAGLDRGADDYI
VKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGD
DEISLTKREYDLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIR
YLRGKIDIPGKESYIQTVRGMGYVIREK
>M6_Spy1725 Two-component response regulator
MFKILVVEDDDTISQVICEFLKANNYDPDCVFDGQAALDKWQTTSYDLII
LDIMLPSLSGLEVLKTIRKTSDVPIIMLTALDDEYTQLVSFNHLISDYVT
KPFSPLILIKRIENVLRVSTPDEKRQIGDLLVDETEHSVYWQGTLVKLTK
KEYDIIDYLAKRHQKIVTRDQLMDDIWGYSELDTRVLDNHIKNLRKKMTG
IPLKTITGMGYLLGERE
>M6_Spy0006 Transcription-repair coupling factor
MDILELFSQNKKVQSWHSGLTTLGRQLVMGLSGSSKALAIASAYLDDQKK
IVVVTSTQNEVEKLASDLSSLLDEELVFQFFADDVAAAEFIFASMDKALS
RIETLQFLRNPKSQGVLIVSLSSLRTLLPNPDVFTKSQIQLTVGEDYDSD
TLTKQLMTIGYQKVSQVISPGEFSRRGDILDIYEITQELPYRLEFFGDDI
DSIRQFYPETQKSFEQLEGIFINPASDLIFEASDFQRGIEQLEKALQTAQ
DDKKSYLEDVLAVSKNGFKHKDIRKFQSLFYEKEWSLLDYIPKGTPIFFD
DFQKLVDKNARFDLEIANLLTEDLQQGKALSNLNYFADNYRELRHYKPAT
FFSNFHKGLGNIKFDQMHQLTQYAMQEFFNQFPLLIDEIKRYQKNQTTVI
VQVESQYAYERLEKSFQDYQFRLPLVSANQIVSRESQIVIGAISSGFYFA
DEKLALITEHEIYHKKIKRRARRSNISNAERLKDYNELAVGDYVVHNVHG
IGRFLGIETIQIQGIHRDYVTIQYQNSDRISLPIDQIGSLSKYVSADGKE
PKINKLNDGRFQKTKQKVARQVEDIADDLLKLYAERSQQKGFSFSPDDDL
QRAFDDDFAFVETEDQLRSIKEIKADMESMQPMDRLLVGDVGFGKTEVAM
RAAFKAVNDHKQVAVLVPTTVLAQQHYENFKARFENYPVEVDVLSRFRSK
KEQAETLERVQKGQIDIIIGTHRLLSKDVVFSDLGLIVIDEEQRFGVKHK
ETLKELKTKVDVLTLTATPIPRTLHMSMLGIRDLSVIETPPTNRYPVQTY
VLENNPGLVREAIIREMDRGGQIFYVYNKVDTIEKKVAELQELVPEASIG
FVHGQMSEIQLENTLIDFINGDYDVLVATTIIETGVDISNVNTLFIENAD
HMGLSTLYQLRGRVGRSNRIAYAYLMYRPDKILTEVSEKRLEAIKGFTEL
GSGFKIAMRDLSIRGAGNILGASQSGFIDSVGFEMYSQLLEQAIASKQGK
TTVRQKGNTEINLQIDAYLPDDYIADERQKIDIYKRIREIQSREDYLNLQ
DELIDRFGEYPDQVAYLLEIALLKHYMDNAFAELVERKNNQVIVRFEVTS
LTYFLTQDYFEALSKTHLKAKISEHQGKIDIVFDVRHQKDYRILEELMLF
GERLSEIKIRKNNSVFK
>M6_Spy0978 Transcriptional regulator, GntR family
MKNGIKLDIPLFFLYHLISTNIYITQKGDQMSWKFDEKSPIYAQIAQHVM
MQIISQEIKSGDQLPTVREYAEIAGVNPNTMQRAFTELEREGMVYSQRTA
GRFVTDDQKLIARKRRELAISELESFITNMTKMGFSHTEIIPVLTSFLKE
DSQ
>M6_Spy1720 trans-acting positive regulator
MYVSKLFTSQQWRELKLISYVTENADAIGVKDKELSKALNISMLTLQTCL
TNMQFMKEVGGITYKNGYITIWYHQHCGLQEVYQKALRHSQSFKLLETLF
FRDFNSLEELAEELFVSLSTLKRLIKKTNAYLTHTFGITILTSPVQVSGD
EHQIRLFYLKYFSEAYKISEWPFGEILNLKNCERLLSLMIKEVDVRVNFT
LFQHLKILSSVNLIRYYKGYSAVYDNKKTSHRFSQLIQSSLETQDLSRLF
YLKFGLYLDETTIAEMFSNHVNDQLEIGYAFDSIKQDSPTGCRKVTNWIH
LLDELEINLNLSVTNKYEVAVILHNTTVLKEEDITANYLFFDYKKSYLNF
YKQEHPHLYKAFVAGVEKLMRSEKEPISTELTNQLIYAFFITWENSFLKV
NQKDEKIRLLVIERSFNSVGNFLKKYIGEFFSITNFNELDALTIDLEEIE
KQYDVIVTDVMVGKSDELEIFFFYKMIPEAIIDKLNVFLNISFADSLPLD
KPIKNPLDFHRKELTLPTPPNKLHAPPSTT
>M6_Spy1826 ArgR
MNKMERQQQIKRIIQAEHIGTQEDIKNHLQKEGIVVTQATLSRDLREIGL
LKLRDEQGKLYYSLSEHVATPFSPEVRFYVLKVDRAGFMLVLHTNLGEAD
VLANLIDNDAIEDILGTIAGADTLLVICRDEEIAKRFEKDLAAGL
>M6_Spy1425 trans-acting positive regulator
MIWLIIFMKLVSNYLKRGSAMKIEDLMDKERRAQYRLLVTLYHAKETLRL
KDLMRLSNLSKVTLLKYIDNLNHLCREQGLACQLLLEKDSLSLKENGQFH
WEDLVALLLKESVAYQILTYMYCHEHFNITNLSVELMVSEATLNRQLAHL
NQLLSEFDLALSQGRQLGSELQWRYFYFELFRHTLTRQGRDALVNQLDAS
HLATLIERLIGQSLSAEALEQLLIWLAISQARMSFQKGYNDHFLRDSDFM
TSNIFFKRLESMLLRYLRRYALEFDAFEAKSLFVFLHAYPLLPIASMKYS
LGFGGPIADHISEALWLLKKAHVIIHQTKEEIIYGLGIFFSKAYFFKGAI
LSQPTNSQYLYQLVGEDKRALLRVIINHLVLQMDQETDFSQQLSDDILAL
LIFSIERHHEPLLVGLALGQNKVEAAIAELAIRRHLGHRRDFQLMPYDHQ
KVYDCLITYQTVCLPRQDLPYYRLKQYSSPYELTALEAFLKDLFQQKNTR
EEELSLSPAAKSSFAHKIV
>M6_Spy1619 DNA-directed RNA polymerase delta chain
MVENDKIRRTALKLDVFAGQEKSELSMIEVARAILEERGRDNEMYFSDLV
NEIQNYLGKSDAGIRHALPFFYTDLNTDGSFIPLGENKWGLRSWYAIDEI
DEEIITLEEDEDGAQKRKKKRVNAFVDGDEDAIDYRDDDPEDEDFTEESA
EVEYDEEDPDDEKSEVESYDSELNEIIPEDDFEEVDINEEDEEDEEDEEP
VL
>M6_Spy1595 Hypothetical cytosolic protein
MVLFLIRIFSDSDKEENMGIEKTVSELADILGVSRQAVNNRVKSLPEEDL
DKNEKGVTVVKRSGLVKLEEIYKKTIFDDEPISEETKQRELLEILVDEKN
TEITRLYEQLKAKDAQLASKDEQMRVKDVQIAEKDKQLDQQQQLTAKAMA
DKETLKLELEEAKAEANQARLQVEEVQAEVGPKKGFLTRLFAK