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# Tropheryma whipplei str. Twist, twist

>TWT594 unknown
MNSVNRCAVSKGDRSFANISFNTVPYLAVRIVYSVSHTIYSYANPSLKAR
VLLYTQSQSNVSITPILYGSFSISTYVLVDTTGATSGSTGLPKGLSFTSG
TITGSIDIRPHVRLNCVCAPEWILLTSSTSKKR
>TWT331 undecaprenyl pyrophosphate synthetase
MGGKMLRSVSELIYKVYARYLLGQINLNNLPGHVALIVDGNRRWARKEKR
DRISDGHRAGAGKAVDFLHWCDELDINIVTLYLLSNDNLKNRNRQELNDL
VQVICDLIAQVSKRWKVNHVGSCENLPELLGNSLEGVKSSTKTNRYSERS
MTVNLAIGYSGRAEITEAVRKIVNTYPIGDLPEKITEEVISANLYTGGLS
DPDLIIRTSGEQRLSDFMPWQSTHSEFYFLEALGPDLRKVDFLRAIRDFS
IRRRSFGA
>TWT721 unknown
MTQKVEFPPRHVTEEKLMEFARAVHTQNKIYHSTAAATSSGYPGLVAVPT
FGAVWVGQILEYIISSDLNIDYSHIVHGEQHFLYKRPIFAGDILRPILRI
KRDRAFGNARQIVLEVTLLSEGSNDDVLVMTITLIVRGKA
>TWT484 1-deoxyxylulose-5-phosphate synthase
MCTKRQYGLLESIRSPRDLDSFTPHQLDELECQVRDFLIQSVAKTGGHLG
SNLGVVELSIALHRSFRSPEDCIIFDVGHQCYVHKLITGRHDFKALRCKN
GLSGYPSRHESNHDIVENSHASAALSWADGVSRARTLLGNDNYVIAVVGD
GSLTGGMCWEALNNISDDNNRRLVIVVNDNGRSYARTIGGIARFLNAVRA
SKSYLWLRESSEAVFSHMGSPGRRLYQGIRGAIHGFLSRFSSSNKLFSNL
DIRYLGPINGHNRKALEKAFKQAKQYARPIIVHVITEKGHGYPPALEDAL
DCLHTVGVIDPSTGKSASVQGQVRQDTWTGVFGEELLRLAESNTNIVAVT
AAMLHPTGLSMFAEKFPHRVFDVGIAEQHAVASAAGLAYEGLHPVVAIYS
TFMNRAFDQVMMDVALHGAPVTFVLDRAGITGPDGASHHGIWDLSLLRIV
PGIKLYAPRDASTLRNTLALVCSEDCPTAIRFPRGSVCDDLPALRSLDDG
IDVLYGSCDREDIVIVAIGVMAHACVRAAQLLAESGIESTVINPVCFWPL
HRQVLARVSKAKLVVLAEEGAKSPGLGDYIAGRRLLEFVIPGDFQPQGSR
DELLDAIGLNGEHIARKIKARFNQIINCV
>TWT066 unknown
MGLLVLIILSDACISLLAFVDCVLREREKIQVLSRSLWLVTVLLVPFVGA
LLWLTIGRGWGKVFSKPEHGEGGS
>TWT093 unknown
MWEKIADLRRSLTLSGVFFVYFTRKVFSYRLGLSSRMFILGICVLLYGTV
LIYRLSLLAPVFYDFVTLIGAAESIINLFMAFLFAKILFLRSGGLMNFTM
QLPLKNKERTMALTICEILIVFMGFTILYSPEAIVSTWKTGQPAYLLVNG
LMPGFITYILCSLIYNLSVRIFILFNLSRLSHIGGIIVTIFAFLGLLIFV
GQSVQSLLPAPGQSIKQAYDHLQTDVFLIFNVFFWLFQHYGLLTSILAFL
ISLIILFPALIISIPSKYPDVHRFIKFPVPFINSTLWPFIAVFIRRIEWW
VAVVVSILSIPLGGFVLILLNLHLLALFSAGIYMFSMSRAIRLLPGYRLS
ATRETLYMFAAQALCICPFLMLVQLALYIASFASGTIVPHDPINLSVILM
FGVILPTFIGILFVHNEDNPVQAFAGYFVVSIIAMVTYLAISVTGQIFLL
ILFTEAIVAIPLTILAVQAVRKSERYA
>TWT321 putative exidoreductase
MTDLGLIVFDSDVLRDKNVLITGGSRGIGAKTAYFLAQGGAQVSIVYRNG
AARADKVLHEIESGTGIKGCAVRADITTDQDVLRRFLKEKVEKLDILILN
ASGGMESGMPGDYPMRLNRDAQLNTVETCLPFMPAGSRVVFVTSHQAHFI
TTCQTLPEYEKVALSKRAGEDALVQKMKDIPYIGFVVVSGDMIVGTVTAM
LINRLYPGALDERRNKTGKLYDVSEFAAEVARAAIDPIPEGNIKFVGDIS
TFLTDTEG
>TWT720 unknown
MLDLFKMPLGSQIFSDTKLVSRDDLVRYAAASGDFNPIHYRDDFARAVGL
PGVICHGMLTMALAIAPLMTQLGTDVSRLSSYGVRFSKPVPVPVGKNPLD
EQSVGALLSIKAFLRKREDSKAIIELIVSLDDETVLTKAFAEISLKI
>TWT507 acyltransferase family protein
MKETRLPSRFWVFTFLINPLVRLLFRYTLRGNVPLRGPVIIVANHNSELD
PILFAIAIWRMGRKPYFMAKRQLFSVPALGACLRFLRQIPVTRPSDTPCG
DMTENTHAPSLLTAIRRLRAGGVIVLYPEGSVTRHPELWLDSFNPGFVHL
ASLTGTPIICAAQWGAQKTLPYGKKLPKFGLRNAYSVVFCAPVHIPRKKL
SDEEIKRFSNLMKEKINTALAAIRLSDETGFMRHERGWVAQ
>TWT252 acp, acyl carrier protein
MSLSREKVLESIAQIVHDETGIDKGSVQLDKAFVDDLDIDSISMMTIVVN
AEEKYGIEIPDDKVRELRTVGDAVDFIIAAKA
>TWT020 bccA, biotin carboxylase
MKKITRLLIANRGEIAVRVIRACRDKAIASIAIYSDQDRDAVHTQLADEA
YCLEGETAAETYLNIEKILDIAKLSRADGIHPGYGFLAESPEFAEAVSSA
GITWVGPRAGVIALLADKLSARKIAEQVGVPVPPGGEHVVSCASEVHNFA
DKYGLPIAIKAAYGGGGLGMKVVKQKKNIDELFASAQREAQAAFGNKECF
IEKYIDRPRHVETQCLADLFGNVQVVSTRDCSVQRRHQKLIEEAPAYTLT
DKQEETLITASKAVMKAAEYSGAGTCEFLIDQDGKIFFLEVNARLQVEHP
VTEEITGIDLVLEQINIAEGKLLKNLETPVYKGHSLEFRINAEDANSGFM
PRHGKVVKFEPPGGLGIRIDSGIKAGDTIGAAFDSLLCKLIVTGNNRECA
LARARRALDEFVIDGVTTLIPFHRNILNQPDFINGGMYTGWVENEYSKLV
NKQTDASTVPDIQDTLSVSKNLREIIVEVNRKQIRVRLPSPIGEYPTERQ
KPPGRRVGHNFRQKTQEKNPDSIFSPMQAVVVKVNVTEGQSVKKDDLLIV
LEAMKMEQPIVAPRDGVVEKINAHTGETVPSGHELLRLKKV
>TWT445 cdsA, phosphatidate cytidylyltransferase
MNEAAMLRYFFMLKQRVQARTGRDLVLAIGVGLILGGLLLISLFVFLHLF
VLVCILVGVTCLAEIFTATHTRGIFIVRPFLTLSTVVLPVLAFFFASWFL
PSIAFFMLTILLAQFFLRARFSLHSLFIFLYIPITVSLFAFIAAHPTGRL
WVFFMLVTVIASDTFSYVFGTLFGRHLLAPRISPNKTWEGLMGGFFSSLF
FGTLTGILLLHKSLLFSATAASILFLFAILGDLAESYIKRRLGVKDMSGI
LPGHGGMLDRVDSMLLNIFPILLLVHMNFV
>TWT064 cls, cardiolipin synthetase
MKPYLFILAALLLADLVIRIGCLFVVPRNRRPNSANAWLLTIFFLPFIGW
FLFLIIGSYKLPKSRREKQALINQLVANALSDHAVLDNVDLQWLPSLVKL
NRNLGSMPMVAGTRVHILTDTSVIMEQMVSAIDSAKSSVHVEFYIFSLDE
FTQGFFTSLENATARGVKVRVLYDHIATLRVPGYLNMKSRLKRNGIEFYP
MLPIQPFKLKYQRPDLRNHRKLLVIDDAIAFVGSLNIIDPFYNTRGRKKM
FWQDAMLRLEGPVISGISAVFVSDWYAETGQLLRDYRIVKTSSGDSFTEN
RTQSNSVDRSCPSTNNVLCQVVPSGPGFEGENNLQLFLMLLYASQKRVAI
TSPYFVPDEAMTLAIASATKRGVSVELFLSENHDQKIVYHAQCSYYEQLL
RSGVKIWLYRAPNFLHSKYVTVDDDVAVFGSSNFDMRSFNLNMEMSLLLY
SKEFVAKLQAVEQENRANSSLLTLDEWMHRGKMDRLKDNLARLTSALQ
>TWT089 dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase
MQRVIIVGSTGSIGTQAIDFILKNRDSFLVVGLAASTQTSLLREQAQVLG
TKNTAQGASEAAELIEATEADVVLNAITGAAGLLSTYATLKTGKRLALAN
KESLIMGGKYFLDMTTFKGQITPVDSEHSAIAQAMKSGKFSEVNKLILTA
SGGPFYDRESLEGITLKDALDHPTWNMGPMISINSATMFNKGLEIIEAHL
LFGIPYSQIDVVIHPQSIVHSMVEYKDGSVIAQASVADMTLPIGYALSWP
NRALNAVRPLEWGARQRWDFLPPTENSMRSINLARRAGEAGGVYPAVLNA
SNECAVEAFMAGKISFARIIHVTETVFNLYTKQHTNRESAKNPIEVILEE
DARTRELAKTVIENMSAD
>TWT254 fabD, malonyl CoA-acyl carrier protein transacylase
MASICDTTPEECAAAGNAVITCPGQGAQKSGLLNEWLDLPGSLEFFQAQS
DFLKIDLIKHGTISDTDILRDTRIAQPLIVALGIFVIRTLQQKAKIIQSM
PEEGLNGANPTERIMRCVGLAGHSVGEITAAFGAGVLTEKNAMRLVKHRA
NQMYKSTQIFDTGMVAVLGQSENLEEYITQRYKLFPANYNCPGQIVFAGL
RENLDVLLANPPEKIKVIPLQVAGAFHTRFMRPAVQNLKKLKFVTDKSFA
KDPDKRIWTNYDGSEIFSGSEYVQLLIDQIARPVRWDLCQKNFENIDYLI
ELPPAGTLTGLARRSLPKVKGIPINTIDDLEEASCCFLL
>TWT313 fabG, 3-oxoacyl-[acyl-carrier protein] reductase
MSSKRTVFITGGNRGIGRAIAEKFKSFNYNVAIGVRQPEAFKDAGCLAVE
CDVTVSSSLTKAFKEVEERFGFVDVAIANAGIIRDTLVLRMKEDDFQHIL
DTNLTGAWRLAKLASRSMMRNKFGRIVFISSVSAGMGGIGQTNYSASKAG
MIGLARALTRELASFGITVNVVAPGIVQTDMVSSIPDNLREELIQRVPIR
RIGLPEEVANAVFWLSSDEASYVSGVVLPVDGGLSMGF
>TWT253 fabH, 3-oxoacyl-[acyl-carrier-protein] synthase III
MNSPQQEPSQASQGGVFRKSRGFLSIQLMTLKKLPAVFFCRILPRVRYSK
IVSLGAYRGERDVYNDELIGPINSSDEWIRRRTGIISRKRALSGTTVVDM
AYAASKEALNDAQMRPEDIDLILVATITHFGHTPSVAAHVGFRIGVQDAI
LLDINAACAGFSYAIFQADLMIKSGVASRALVIGVDKLSEFIDPLDRTIS
FLLADGAGAAILVGSTSMGIGKTVCGGNPGQLESVGLTGSTTDVKSGSAW
PTLRQEGSSIFRWAVWQMAKVAKQILDINQVQPGDLNAFIPHQANIRIID
ELAKQIGLEENVLIAQDICKTGNTSSASIPLAMHSLIKGNPSLSGELALQ
IGFGAGLVYAGQTVVMP
>TWT348 ispDF, IspD
MAVGLLLLAAGVGSRLSSSLPKAFVSVGGLDLIQWCLKNLGQLRTALEVV
VTVPKGFVELCERNVLQSLGTLEKIKIVTGGATRQDSVGLGIRYFSARIT
KLLVHDVARAFTPPEIYLSVIKQLETSKAVIPVIAIVDSIKKVNMQDAYR
EVARGPGEPFHTKSVLHLDRREFFSAQTPQGFDRALLEAAHERSVASNEQ
FADDSVMVAQIEKDITLINGHEASFKVTNPCDLQRAEFAASSLLSKSNVS
PVNISQPPISALSMPLPLIGVGIDFHKFILDESPLFLACLEWKNYRRLQG
HSDGDVVAHACTTALLSAANMGDIGSVFGVDLAATKDASGAYFLESTNRL
LATNGFCVLNIAVQVISNTPRLADRRVEAEHAISDCLSGARISLSSVTTD
GMGFLGRGEGIGAIAVAQIYHR
>TWT605 ispE, 4-diphosphocytidyl-2-C-methyl-D-erythritolkinase
MMIKKITRVSVPGKINPILLVGPKRPDGYHGLFTVYLGISLYEHINITLD
DSYNRSREMKTDGGNTWRASHSKPLNTANTMGEPFSHSEYSVHADQSEFY
LNELTEHSGQDNPCMNTSRLNTNRYGHPVVHPCPKIHCICTQSNIAAIGS
DCTGCVDIAQACKMLRGGLGCTQDPCVKNPHTQCFTDVSNHAMRNVLPLN
VSNTEQFPIQIEYANGRNPVLNPMDDLAMRAALLLSKDIDLQNTHILPST
RISIEKNIPVAAGLAGGSADAAAVLLGINSAWQTNYSRCDLLGKAGALGA
DVPFLIWGGAAYGSGTGSCVTFFETQTLYWVLCFSKHPLSTRKVFQELDR
QRSGAGCNHHPVFSNPAECAEMLKKAIKRGPEALAALLHNDLTSAAKMLM
PEIAERIKAAERCPGILRAIISGSGPTLALLAEDAEAANRACSILKDTGV
ICKAVSSPAYSSIYWQT
>TWT186 ispG, 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
MSIDLGLPKVREVLSPRRKTRRIKLGKVFVGGDSPILVQSMTTTQTTNID
ATLQQIAELTAAGCDIVRVAVPSRDDAQVLHIIAKKSQIPVIADIHFQPN
YVYAAIDAGCAAVRVNPGNIRKFDDQIGKIAEKAKAAGVSIRIGVNAGSL
DPRLLEKYGRPTAQALVDSAVWEAGLFEEYDFHDFKISVKHHDPVTMVKA
YRLLAERGDWPLHLGVTEAGPAFQGTIKSSTAFAVLLAEGIGDTIRVSLS
APPVEEVKVGLEILRSLGLRERRLEIVSCPSCGRAQVDVYRLAEEVTKGL
EKLTVPLRVAVMGCIVNGPGEAREADLGVASGNGKGQIFVRGQVIKTVPE
SEIVPTLLEEANRLAGEMPFSSGSPTIAIV
>TWT642 ispH1, IspH protein 1
MHHTGLGSGVAKRVLLASPRGYCAGVDRAVIAVEKALERHGPPVYVRKQI
VHNVHVVGSLEKRGAIFVDQVDQIPPGAVTIFSAHGVSPAVVHSANERGL
QVIDATCPLVTKVHREVIRFSKAGYFILLIGHSGHEEVEGTSGHAPDRVL
IVNSPDEADTIDVPHTDKLVWLSQTTLSVDETLETVKRLRLRFPHIQDPP
SDDICYATQNRQAAVKKIAPLSDLVIVVGSANSSNSVRLVEVALENGAKA
AVRLDYADELDPALLDKVDVVGVTSGASVPEILVRDLLEVLARAGYTKVE
SVQTAVEDLVFSLPKGLRESRK
>TWT251 kasA, 3-oxoacyl-[acyl-carrier-protein] synthase
MSRQVVVTGLGVCCPLGIGTELAWQALLDGESGVRTLPDRCTKGFDLPVT
FAGLVPDGVEDLLARTEVNRLDRAGQISLIAARQAVEDAGDIKQNPERTA
VSWGTGIGCINTVLSAWDRLAEKGPGRVLPMTVPMLMPNAPAVAVGMKMQ
ARAGIHTSVSACAASTESIAVGFDMIRSNKADVVIAGGSESAINPLTISA
FASLSALSTYSGNPEHASRPFSKNRDGFVVSEGAAVLILEEKTRARARGA
KIYAEISGALFNSDAHHITAPEPDGKMATTAMRNTLKMSGLSPEDITYVN
AHATATILGDISEYKALLALFEDHLANVYVSATKASTGHLLGGAGALEAV
FTVKAVSESIIPPTINCDEQDPDIQLRIQRHPKKLSRPFAATSNSFGFGG
HNAVVAFTPTD
>TWT111 menE, O-succinylbenzoic acid-CoA ligase
MPLMMAWSDSRFLQARPHALRMQQMSQKKGVTHSSKNVGQTGQAFPGASS
MTKALMRGQITLDSVKRVLEDERFAICASEEPLSCGGKIMVDDAVCLVIN
TSGSTASPKRVAFSSSSLMNSARACCSVLGYGQWVLCLPKQYTAGVRVLV
RSILSGTKPIDISEDRFSPENFIHACRRLSCSNTFTALVPTQLSALVRVA
EDDKNVAKVLSGFTGVIVGGQHIARSLLERSRLLGINLFTSYGLTETFGG
CVYNGLPLPGVQIQIIDGRPAIASPSLALGYLKENGQIDETGFFFDRGER
WFHTNDLAVMNRGKLIIHGRIDRVINSGGMKLDLNAIETALRSLDCVEDA
VLLGVKSKKWGQQFCAFIDIGDVTKADRTDCLQKINTLLSTFGRACRSGQ
IKLIHPIPRTFSGKPDRIALQRGLQNNI
>TWT023 pccB, propionyl-CoA carboxylase beta chain
MTDNFDESSRGLEKYRQAYEVAVTLREDSAKEKQHSKGKMTARERIDKLL
DENSFTEIDQFAMHSASGFGIEKNHPYGDSVVTGFGSIDGRKVAVYSQDF
TVFGGSLGEVAGRKIVKTMDLAMSAGIPVIGLLDSGGARIQEGIAALTKY
GEIFKRNVAASGIIPQISIVMGPAAGGACYSPALTDFVIMVDQISYMFIT
GPDVIKAVTGEEVTFEDLGGANMHNATSGVSHYMAHSEDDAIAYARELIG
FLPSNNMSDPPTWPQDIHTEESDLELNSIVPENPNKPYDMQFVIERIVDD
GNFLEIQSAYAKNVIIGFARISGFSIGIVANQPAHMAGALDINASEKAAR
FVRFCDAFSIPILTLVDVPGYLPGTEQEWTGIIRRGAKLLYAYSEATVPM
VTIILRKAYGGAYIVMGSKALGADINLAWPSAEIAVMGAQGAVNILYRND
IKRLVQAGEDANPMKEKLVKEYTDKFANPFIAAQRGYLDAIIEPAQTRIA
IATAFQTIRTKRYKQIDRKHGSIPL
>TWT612 pgsA, CDP-diacylglycerol--glycerol-3-phosphate3-phosph atidyltransferase
MLPNVITCTRIAFAFPLFFLCLDKDFRWLTLCLFLIGMLTDGLDGFIARK
YNSVSKFGALLDPIADKILVASVVLPLCILGEIPWWVFVVIFLREVSVTI
FRLIVAKRKVISANTWGKAKTVVQTLAFSVALLPIFAAPDQMYSSNPSLS
DYVGGLGDSVIFFPPISTGLSFVRTGLIFAAVFITACTGIVYCVAACRLK
H
>TWT214 plsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase
MYFLMKLLLGPLLQLLYRPWSVGWDNIPKKGGAIIASSHMSFIDSIIISH
FSKRKVHFLAKREYFTGRGFKGFLMRCFFRLTNQIAMDRSGGTASEKSLQ
AALDILAKGRLLAIYPEGTRSHDGKLYRGRTGIARLVLKANVPVIPASVF
NTHLAMPRGKYLPRFFRVGVIFGKQLSFERYLGFEGDRFVLRSITDEVMY
EIYSLSGRQYTDAYASNARLK
>TWT286 uppS, undecaprenyl pyrophosphate synthetase
MEIFSVDWTGQTPPHIPRKSLPRHVAVVMDGNGRWANQRNLPRIEGHKAG
ESALIDVVAGAVQVGVPYLSLYVFSTENWLRAPDEVRFLLRFTRDVIARR
RELFAHWGVRVRWSGVPNRLGKVLVKELRDTEEITKKNTAMNLNVCLNYG
SRQEIVNAIKSIVSDVNSGLISAKSVNEKIISRRMYMPDFPDVDLFLRSS
GENRMSNFMLWQSAYAELIFMSKLWPDFRRDDFWAALRAYSGRSRRFGR