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# Streptococcus pneumoniae TIGR4, TIGR4; ATCC BAA-334

>SP_0885 hypothetical protein
MNYLVISPYYPQNFQQFTIELANKGITVLGIGQESYEQLDEPLRNSLTEY
FRVDNLENIDEVKRAVAFLFYKHGPIGRIESHNEYWLELDATLREQFNVF
GAKPEDLKKTKYKSEMKKLFKKAGVPVVPGAVIKTEADVDQAVKEIGLPM
IAKPDNGVGAAATFKLETEDDINHFKQEWDHSTLYFFEKFVTSSEICTFD
GLVDKDGKIVFSTTFDYAYTPLDLMIYKMDNSYYVLKDMDPKLRKYGEAI
VKEFGMKERFFHIEFFREGDDYITIEYNNRPAGGFTIDVYNFAHSLDLYR
GYAAIVAGEEFPASDFETQYCLATSRRANAHYVYSEEDLLAKYSQQFKVK
KVMPAAFAELQGDYLYMLTTPSRQEMEQMIADFGQRQE
>SP_1271 putative 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
MIYAGILAGGTGTRMGISNLPKQFLELGDRPILIHTIEKFVLEPSIEKIV
VGVHGDWVSHAEDLVDKYLPLYKERIIITKGGADRNTSIKNIIEAIDAYR
PLTPEDIVVTHDSVRPFITLRMIQDNIQLAQNHDAVDTVVEAVDTIVEST
NGQFITDIPNRAHLYQGQTPQTFRCKDFMDLYGSLSDEEKEILTDACKIF
VIKGKDVALAKGEYSNLKITTVTDLKIAKSMIEKD
>SP_0320 oxidoreductase, short chain dehydrogenase/reductase family
MTNTSFSIEQFSLKGKIALITGASYGIGFAIAKSYAEAGATIVFNDINQD
LVNKGIEAYREVGIQAHGYVCDVTDEDGIQAMVKQIEQEVGVIDILVNNA
GIIRRVPMCEMSAADFRKVIDIDLNAPFIVSKAVIPSMIKKGHGKIINIC
SMMSELGRETVSAYAAAKGGLKMLTRNIASEYGGANIQCNGIGPGYIATP
QTAPLRELQEDGSRHPFDQFIIAKTPAARWGNTEDLMGPAVFLASDASNF
VNGHILYVDGGILAYIGKQPE
>SP_0415 enoyl-CoA hydratase/isomerase family protein
MEHIIYQLEEDLAILTLNRPEVANGFHIPMCEEILEALTLAEENPAVHFI
LINANGKVFSVGGDLVEMKRAVDEDDIPSLTKIAELVNTISYKIKQIAKP
VLMEVDGAVAGAAANMAVAADFCLATDKAKFIQAFVGVGLAPDAGGIHLL
SRSIGVTRAAQLAMTGEALTAEKALEWGLVYRVSEAEKLEKTREQLLKKL
RRASSNSYAAIKKLVWESQFKDWQGYATLELNLQKSLAQTEDFKEGVRAH
SERRRPKFTGK
>SP_1624 acyltransferase family protein
MFYTYLRGLVVLLLWSINGNAHYHNTDKIPNQDENYILVAPHRTWWDPVY
MAFATKPKQFIFMAKKELFTNRIFGWWIRMCGAFPIDRENPSASAIKYPI
NVLKKSDRSLIMFPSGSRHSNDVKGGAALIAKMAKVRIMPVTYTGPMTLK
GLISRERVDMNFGNPIDISDIKKMNDEGIETVANRIQTEFQRLDEETKQW
HNDKKPNPLWWFIRIPALILAIILAILTIIFSFIASFIWNPDKKREELA
>SP_2057 conserved hypothetical protein
MRIKWFSLIRIIGLLLVLLYHFFQTIFPGGFFGVDVFFTFSGFLITALLI
EEFSKNNEIDLIGFFRRRFYRIVPPVVLMVLVTMPFTFLVRQDYVAGIGG
QIAGVLGFMTNFYELLTGGSYESQFIPHLFVHNWSLAVEVHYYILWGLAV
WFLSKQAKSNGQLKGMVFLLSAVAFLISFFSMFIGSFLVTSYSSVYFSSL
THVYPFFLGSMLATIVGVRQTTSLVKQLDKIWDLRKTLVVFGGGFGFLVL
LTFFVKFTYLFAYLIGFLLASLAALAMILAARVLHEKTHHIQESKIISFL
ADTSYAVYLFHWPFYIIFSQLTSNLLAVLLTLICSYGFASLSFYVLEPWI
AGKNTPIVQTLRPLPYIHAILAAGTGILTIIVCTVTLLAPQVGAFETDLT
VNGLKQAATNIGQTKVMAERADANSLGIADGTMLIGDSVALRANTALQTA
LPGAQINAQVSVTTKTANEIMLNNSQNKFLPKTVVIATGVNNPENYKDDW
DSIVKNLPKGHHMILVTPYEGDKTKETYAIVEKAAAYMRELAEKTPYITI
ADWNQVAKEHPEIWAGTDQVHFGSESSTIEAGAKLYADTIATALQTAQDK
PVKSK
>SP_0489 PAP2 family protein
MRDKQTFLMKGSFALLLFVILGYMVKFYPEMLVNFDQSIQTAIRGDLPDY
LTILFRALTRLIDIPVIITWVVITAFVFYRKRWKIESFFMLGNLALAGLL
IVTFKNIYQRPRPAILHLVEEKGFSFPSGHSLAVTLMVGTLIVILSQRIK
DQVWRKIVQIVLGLYLVSVLVSRVYLGVHYPSDVLASLCVGLGVLFIEFP
FYDKLRFQWRFKGKQK
>SP_0262 phosphatidate cytidylyltransferase
MTQDLQKRTLFAGIALAIFLPILMIGGLLLQIAIGIIAMLAMHELLKMRG
LETMTMEGLLTLFATFALTIPLENYLTFLPVDGNVVAYSVLISIMLGTTV
FSKSYTIEDAVFPLAMSFYVGFGFNALLDARVAGLDKALLALCIVWATDS
GAYLVGMNYGKRKLAPRVSPNKTLEGALGGILGAILVTIILMIVDSTVAL
PYGIYKMSVFAIFFSIAGQFGDLLESSIKRHFGVKDSGKFIPGHGGVLDR
FDSMLLVFPIMHLFGLF
>SP_0793 oxidoreductase, short chain dehydrogenase/reductase family
MTKRVLITGVSSGIGLAQARLFLEKGYQVYGVDQGEKPLLEGDFRFLQRD
LTLDLEPIFDWCPQVDVLCNTAGVLDDYKPLLEQTAQDIQEIFEINYIIP
VELTRYYLTQMLENKKGIIINMCSIASSLAGGGGHAYTSSKHALAGFTKQ
LALDYAEAGIQVFGIAPGAVKTAMTAADFEPGGLADWVASETPIKRWIEP
EEIAELSLFLASGKASAMQGQILTIDGGWSLK
>SP_1408 putative acyl-ACP thioesterase
MGLTYQMKMKIPFDMADMNGHIKLPDVILLSLQVSGMQSIELGVSDKAIL
EEYNLVWIIVEYDIEVVRLPRFAEEITIETEALSYNRLFCYRRFTIYNEA
EQELIHMMATFVLMDRDSRKVHVVEPEIVAPYQSDFDKKLIRGPKYESLE
EPISKDYHVRFYDLDMNGHVNNSKYLDWIFEVMGADFLTHYIPKKINLKY
VKEVRPGGVITSAVERTGLESKHEITSDGVINAQAIITWQEIKKA
>SP_1045 conserved hypothetical protein TIGR00147
MKKAMVIINPTSGGEKALDYKEKLENKAKEYFEYVETKITEKALDATHFA
EEASREQYDAVVVFGGDGTVNEVISGIDERDYIPKLGIIPGGTGNLITKL
LEINQDIDGAIDELDFDLTNKIDIGKANDNYFGYIFSIGSLPEAIHNVEI
EDKTKFGILTYAVNTMKSVMTDQVFNIKVETENGNYVGEASHVLVLLTNY
FADKKIFEENKDGYANILILKDASIFSKLSVIPDLLKGDVVANDNIEYIK
ARNIKISSDSELESDVDGDKSDNLPVEIKVLAQRVEVFSKPKED
>SP_1726 3-hydroxy-3-methylglutaryl-CoA reductase
MKISWNGFSKKSYQERLELLKAQALLSPERQASLEKDEQMSVTVADQLSE
NVVGTFSLPYSLVPEVLVNGQEYTVPYVTEEPSVVAAASYASKIIKRAGG
FTAQVHQRQMIGQVALYQVANPKLAQEKIASKKAELLELANQAYPSIVKR
GGGARDLHVEQIKGEPDFLVVYIHVDTQEAMGANMLNTMLEALKPVLEEL
SQGQSLMGILSNYATDSLVTASCRIAFRYLSRQKDQGREIAEKIALASQF
AQADPYRAATHNKGIFNGIDAILIATGNDWRAIEAGAHAFASRDGRYQGL
SCWTLDLEREELVGEMTLPMPVATKGGSIGLNPRVVLSHDLLGNPSAREL
AQIIVSIGLAQNFAALKALVSTGIQQGHMKLQAKSLALLAGASESEVAPL
VERLISDKTFNLETAQRYLENLRS
>SP_1916 PAP2 family protein
MKNYQEWYRNISSRLTSCPILLFLLRSFNRLMTVAMPLVYLILLVTTYLQ
LGLGQQVGVYVLIPASGFVALSLFRKKINHPRPYETWDICPLLDKDSSGR
SMPSRHVFSATIISMACLHASLPIGLVCLIFSALLGLVRVLGGVHYPKDV
LVGYACGLVWGFLFFLF
>SP_0427 accA, acetyl-CoA carboxylase, carboxyl transferase, alpha subunit
MNIAKIVREAREQSRLTTLDFATGIFDEFIQLHGDRSFRDDGAVVGGIGW
LGDQAVTVVGIQKGKSLQDNLKRNFGQPHPEGYRKALRLMKQAEKFGRPV
VTFINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGG
ALALAVADRVWMLENSIYAILSPEGFASILWKDGTRAMEAAELMKITSHE
LLEMDVVDKVISEIGLSSKELIKSVKKELQTELARLSQKPLEELLEERYQ
RFRKY
>SP_0423 accB, acetyl-CoA carboxylase, bitoin carboxyl carrier protein
MNLNDIKDLMTQFDQSSLREFSYKNGTDELQFSKNEARPVPEVATQVAPA
PVLATPSPVAPTSAPAETVAEEVPAPAEASVATEGNLVESPLVGVVYLAA
GPDKPAFVTVGDSVKKGQTLVIIEAMKVMNEIPAPKDGVVTEILVSNEEM
VEFGKGLVRIK
>SP_0425 accC, acetyl-CoA carboxylase, biotin carboxylase
MFRKILIANRGEIAVRIIRAARELGIATVAVYSTADKEALHTLLADEAVC
IGPGKATESYLNINAVLSAAVLTEAEAIHPGFGFLSENSKFATMCEEVGI
KFIGPSGHVMDMMGDKINARAQMIKAGVPVIPGSDGEVHNSEEALIVAEK
IGYPVMLKASAGGGGKGIRKVEKPDDLVSAFETASSEAKANYGNGAMYIE
RVIYPARHIEVQILGDEHGHVIHLGERDCSLQRNNQKVLEESPSIAIGKT
LRHEIGAAAVRAAEFVGYENAGTIEFLLDEASSNFYFMEMNTRVQVEHPV
TEFVSGVDIVKEQICIAAGQPLSVKQEDIVLRGHAIECRINAENPAFNFA
PSPGKITNLYLPSGGVGLRVDSAVYPGYTIPPYYDSMIAKIIVHGENRFD
ALMKMQRALYELEIEGVQTNADFQLDLISDRNVIAGDYDTSFLMETFLPK
YQEKE
>SP_0426 accD, acetyl-CoA carboxylase, carboxyl transferase, beta subunit
MALFSKKDKYIRINPNRSVREKPQAKPEVPDELFSQCPGCKHTIYQKDLG
SERICPHCSYTFRISAQERLALTIDMGTFKELFTGIESKDPLHFPGYQKK
LASMREKTGLHEAVVTGTALIKGQTVALGIMDSNFIMASMGTVVGEKITR
LFEYATVEKLPVVLFTASGGARMQEGIMSLMQMAKISAAVKRHSNAGLFY
LTILTDPTTGGVTASFAMEGDIILAEPQSLVGFAGRRVIENTVRESLPED
FQKAEFLLEHGFVDAIVKRRDLPDTIASLVRLHGGSPR
>SP_0418 acpP, acyl carrier protein
MAVFEKVQEIIVEELGKDASEVTLESTFDDLDADSLDLFQVISEIEDAFD
IQIEAENDLKTVGDLVAYVEEQAK
>SP_1699 acpS, holo-(acyl-carrier protein) synthase
MIVGHGIDIEELASIESAVTRHEGFAKRVLTAQEMERFTSLKGRRQIEYL
AGRWSAKEAFSKAMGTGISKLGFQDLEVLNNERGAPYFSQAPFSGKIWLS
ISHTDQFVTASVILEENHES
>SP_0199 cls, cardiolipin synthetase
MAPILWITVLILLSIITIISIVNRNTTPENKVTWLLVAFVPVFGPLLYLM
FGERRLSKKEIKQLKKLGSMHFQEANSQLLKEKLKESDKAAYGVIKSLLS
MDTNADIYDQTASTFFPNGEAMWKKMVEDLKKAEKFIFLEYYIIEEGLMW
NRILDILEQKVAQGVEVKMLYDDIGCMATLTGDYAHRLRQLGIEAHKFNK
VIPRLTVAYNNRDHRKILIVDGQIAYTGGVNLADEYINHVERFGYWKDSG
IRLDGLAVKALTRLFLTTWYINRGEISDFDQYHLENHSIPSDGLTIPYGS
GPKPIFRAQVGKKVYQSLINQATESVYITTPYLIIDYDLTETIKNAAMRG
VDVRIITPYIPDKKFIQLVTRGAYPDLLSAGVRIYEYSPGFIHSKQMLVD
EDFAVVGTINLDYRSLVHHYENAVLLYKTPSIREIARDFRNIFADSQEVY
PHSIKTSWYQKLVKEIAQLFAPIL
>SP_2174 dltC, D-alanyl carrier protein
MDIKSEVIEIIDELFMEDVSDMMDEDLFDAGVLDSMGTVELIVEIENRFD
IRVPVTEFGRDDWNTANKIIAGIVELQNA
>SP_0420 fabD, malonyl CoA-acyl carrier protein transacylase
MTKTAFLFAGQGAQYLGMGRDFYDQYPIVKETIDRASQVLGYDLRYLIDT
EEDKLNQTRYTQPAILATSVAIYRLLQEKGYQPDMVAGLSLGEYSALVAS
GALDFEDAVALVAKRGAYMEEAAPADSGKMVAVLNTPVEVIEEACQKASE
LGVVTPANYNTPAQIVIAGEVVAVDRAVELLQEAGAKRLIPLKVSGPFHT
ALLEPASQKLAETLAQVSFSDFTCPLVGNTEAAVMQKEDIAQLLTRQVKE
PVRFYESIGVMQEAGISNFIEIGPGKVLSGFVKKIDQTAHLAHVEDQASL
VALLEK
>SP_0422 fabF, 3-oxoacyl-(acyl-carrier-protein) synthase II
MKLNRVVVTGYGVTSPIGNTPEEFWNSLATGKIGIGGITKFDHSDFDVHN
AAEIQDFPFDKYFVKKDTNRFDNYSLYALYAAQEAVNHANLDVEALNRDR
FGVIVASGIGGIKEIEDQVLRLHEKGPKRVKPMTLPKALPNMASGNVAMR
FGANGVCKSINTACSSSNDAIGDAFRSIKFGFQDVMLVGGTEASITPFAI
AGFQALTALSTTEDPTRASIPFDKDRNGFVMGEGSGMLVLESLEHAEKRG
ATILAEVVGYGNTCDAYHMTSPHPEGQGAIKAIKLALEEAEISPEQVAYV
NAHGTSTPANEKGESGAIVAVLGKEVPVSSTKSFTGHLLGAAGAVEAIVT
IEAMRHNFVPMTAGTSEVSDYIEANVVYGQGLEKEIPYAISNTFGFGGHN
AVLAFKRWENR
>SP_0421 fabG, 3-oxoacyl-[acyl-carrier protein] reductase
MKLEHKNIFITGSSRGIGLAIAHKFAQAGANIVLNSRGAISEELLAEFSN
YGIKVVPISGDVSDFADAKRMIDQAIAELGSVDVLVNNAGITQDTLMLKM
TEADFEKVLKVNLTGAFNMTQSVLKPMMKAREGAIINMSSVVGLMGNIGQ
ANYAASKAGLIGFTKSVAREVASRNIRVNVIAPGMIESDMTAILSDKIKE
ATLAQIPMKEFGQAEQVADLTVFLAGQDYLTGQVVAIDGGLSM
>SP_0417 fabH, 3-oxoacyl-(acyl-carrier-protein) synthase III
MAFAKISQVAHYVPEQVVTNHDLAQIMDTNDEWISSRTGIRQRHISRTES
TSDLATEVAKKLMAKAGITGEELDFIILATITPDSMMPSTAARVQANIGA
NKAFAFDLTAACSGFVFALSTAEKFIASGRFQKGLVIGSETLSKAVDWSD
RSTAVLFGDGAGGVLLEASEQEHFLAESLNSDGSRSECLTYGHSGLHSPF
SDQESADSFLKMDGRTVFDFAIRDVAKSIKQTIDESPIEVTDLDYLLLHQ
ANDRILDKMARKIGVDRAKLPANMMEYGNTSAASIPILLSECVEQGLIPL
DGSQTVLLSGFGGGLTWGTLILTI
>SP_0424 fabZ, (3R)-hydroxymyristoyl-(acyl-carrier-protein)dehy dratase
MIDIQGIKEALPHRYPMLLVDRVLEVSEDTIVAIKNVTINEPFFNGHFPQ
YPVMPGVVIMEALAQTAGVLELSKPENKGKLVFYAGMDKVKFKKQVVPGD
QLVMTATFVKRRGTIAVVEAKAEVDGKLAASGTLTFAIGN
>SP_0382 mvaD, diphosphomevalonate decarboxylase
MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYTETTLSP
LPANVTADEFYINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPT
AAGLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPL
GAWDKDSGEIYPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFD
DWVRQSEKDYQDMLIYLKENDFAKIGELTEKNALAMHATTKTASPAFSYL
TDASYEAMAFVRQLREKGEACYFTMDAGPNVKVFCQEKDLEHLSEIFGHR
YRLIVSKTKDLSQDDCC
>SP_0381 mvaK1, mevalonate kinase
MTKKVGVGQAHSKIILIGEHAVVYGYPAISLPLLEVEVTCKVVPAESPWR
LYEEDTLSMAVYASLEYLNITEACIRCEIDSAIPEKRGMGSSAAISIAAI
RAVFDYYQADLPHDVLEILVNRAEMIAHMNPSGLDAKTCLSDQPIRFIKN
VGFTELEMDLSAYLVIADTGVYGHTREAIQVVQNKGKDALPFLHALGELT
QQAEVAISQKDAEGLGQILSQAHLHLKEIGVSSPEADFLVETTLSHGALG
AKMSGGGLGGCIIALVTNLTHAQELAERLEEKGAVQTWIESL
>SP_0383 mvaK2, phosphomevalonate kinase
MIAVKTCGKLYWAGEYAILEPGQLALIKDIPIYMRAEIAFSDSYRIYSDM
FDFAVDLRPNPDYSLIQETIALMGDFLAVRGQNLRPFSLEICGKMEREGK
KFGLGSSGSVVVLVVKALLALYDVSVDQELLFKLTSAVLLKRGDNGSMGD
LACIVAEDLVLYQSFDRQKVAAWLEEENLATVLERDWGFSISQVKPTLEC
DFLVGWTKEVAVSSHMVQQIKQNINQNFLTSSKETVTSLVEALEQGKSEK
IIDQVEVASKLLEGLSTDIYTPLLRQLKEASQDLQTVAKSSGAGGGDCGI
ALSFDAQSTKTLKNRWADLGIELLYQERIGHDDKS
>SP_1727 mvaS, hydroxymethylglutaryl-CoA synthase
MNDKTEVNMTIGIDKIGFATSQYVLKLQDLAEARGIDPEKLSKGLLLKEL
SIAPLTEDIVTLAASASDSILTEQERQEVDMVIVATESGIDQSKAAAVFV
HGLLGIQPFARSFEIKEACYGATAALHYAKLHVENSPESKVLVIASDIAK
YGIETPGEPTQGAGSVAMLITQNPRMMAFNNDNVAQTRDIMDFWRPNYST
TPYVNGVYSTQQYLDSLKTTWLEYQKRYQLTLDDFAAVCFHLPYPKLALK
GLKKIMDKSLPQEKKDLLQKHFDQSILYSQKVGNIYTGSLFLGLLSLLEN
TDSLKAGDKIALYSYGSGAVAEFFSGELVEGYEAYLDKDRLNKLNQRTAL
SVADYEKVFFEEVNLDETNSAQFAGYENQDFALVEILDHQRRYSKVEK
>SP_2222 pgsA, CDP-diacylglycerol--glycerol-3-phosphate3-phosph atidyltransferase
MKKEQIPNLLTIGRILFIPIFIFILTIGNSIESHIVAAIIFAVASITDYL
DGYLARKWNVVSNFGKFADPMADKLLVMSAFIMLIELGMAPAWIVAVIIC
RELAVTGLRLLLVETGGTILAAAMPGKIKTFSQMFAIIFLLLHWTLLGQV
LLYVALFFTIYSGYDYFKGSAYVFKGTFGSK
>SP_0037 plsX, fatty acid/phospholipid synthesis protein PlsX
MKKIAVDAMGGDYAPQAIVEGVNQALSDFSDIEVQLYGDEAKIKQYLTAT
ERVSIIHTDEKIDSDDEPTRAIRNKKNASMVLAAKAVKDGEADAVLSAGN
TGALLAAGFFIVGRIKNIDRPGLMSTLPTVDGKGFDMLDLGANAENTAQH
LHQYAVLGSFYAKNVRGIAQPRVGLLNNGTESSKGDPLRKETYELLAADE
SLNFIGNVEARDLMNGVADVVVADGFTGNAVLKSIEGTAMGIMGLLKTAI
TGGGLRAKLGALLLKDSLSGLKKQLNYSDVGGAVLFGVKAPVVKTHGSSD
AKAVYSTIRQIRTMLETDVVAQTAREFSGE
>SP_0261 uppS, undecaprenyl diphosphate synthase
MFGFFKKDKAVEVEVPTQVPAHIGIIMDGNGRWAKKRMQPRVFGHKAGME
ALQTVTKAANKLGVKVITVYAFSTENWTRPDQEVKFIMNLPVEFYDNYVP
ELHANNVKIQMIGETDRLPKQTFEALTKAEELTKNNTGLILNFALNYGGR
AEITQALKLISQDVLDAKINPGDITEELIGNYLFTQHLPKDLRDPDLIIR
TSGELRLSNFLPWQGAYSELYFTDTLWPDFDEAALQEAILAYNRRHRRFG
GV