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# Tropheryma whipplei str. Twist, twist

>TWT667 unknown
MFTKHAIRQLIRARRISRVNLQNSYICNKEHLGRSLTLARNLQIVTEKAK
CITCYLPIKGEPDTRYFMTSNKHLKVLLPVIIDRQLYWRIWRNAKEHQGP
FGTFHPAGKNLSKHFLDKTDVMLIPAAAVDKRGYRLGWGKGYYDRYLARV
KRSIPVFAVVFDNEIFDEIPINDWDKKLTGVVTEKRILYFSRTHKPQVRT
RSK
>TWT265 amidotransferase
MTVGVLSLQGSFYEHLFILSRLNTDHIQVKTSEDLSRVTRLIIPGGESTA
MLALTQKSGLFDLVRDRIMSGMPVYGTCAGMIMLSTFVEDFPNQKTLSCL
DIAVRRNAFGRQINSFESEVSFLNSKITVPFIRAPKITQIGEGVDVLSRL
ESGDIVAVRQGNVMATAFHPELTGGAAVHEYFLHLGLE
>TWT484 1-deoxyxylulose-5-phosphate synthase
MCTKRQYGLLESIRSPRDLDSFTPHQLDELECQVRDFLIQSVAKTGGHLG
SNLGVVELSIALHRSFRSPEDCIIFDVGHQCYVHKLITGRHDFKALRCKN
GLSGYPSRHESNHDIVENSHASAALSWADGVSRARTLLGNDNYVIAVVGD
GSLTGGMCWEALNNISDDNNRRLVIVVNDNGRSYARTIGGIARFLNAVRA
SKSYLWLRESSEAVFSHMGSPGRRLYQGIRGAIHGFLSRFSSSNKLFSNL
DIRYLGPINGHNRKALEKAFKQAKQYARPIIVHVITEKGHGYPPALEDAL
DCLHTVGVIDPSTGKSASVQGQVRQDTWTGVFGEELLRLAESNTNIVAVT
AAMLHPTGLSMFAEKFPHRVFDVGIAEQHAVASAAGLAYEGLHPVVAIYS
TFMNRAFDQVMMDVALHGAPVTFVLDRAGITGPDGASHHGIWDLSLLRIV
PGIKLYAPRDASTLRNTLALVCSEDCPTAIRFPRGSVCDDLPALRSLDDG
IDVLYGSCDREDIVIVAIGVMAHACVRAAQLLAESGIESTVINPVCFWPL
HRQVLARVSKAKLVVLAEEGAKSPGLGDYIAGRRLLEFVIPGDFQPQGSR
DELLDAIGLNGEHIARKIKARFNQIINCV
>TWT533 aminotransferase
MNTEYLHVLWFNPDTDCEPRFYDVHHPLIPATSDAINRGVGVFETIGILS
GRILNLDEHLERMCTSANRLGLRSIEPDRWRSLILQSAKKIADQERAGLR
VVYARNSNRSYLAWIAAFAVRDPDALSKGIKVITLQRGVRSDAGRLYPWL
LFGAKTVSYAVNMHALEVAQARGADDAIFLSEDGLVLEGTTSNLIAYNKG
AFITPCPRTMSILPGTTQKRLFMLLEAEGKKTLETSVATEALYNSEGVWL
TSSVRMITPVVSVDGNRVRFDPGLTDWLNELLARSAV
>TWT690 dipeptide ABC transporter substrate-binding-like protein
MMGNMDKGLDSQKQETARSCRFEVETNLPTKFGTLRVRGYRDIKNNEHIA
LITKQIKSEDVLLRIHSECITGEVFMSLKCDCHGQLHKALERISAEGGLV
IYMRGHEGRGIGILNKLRAYRLQEQGLDTFDSNVKLGLPVDARDYGPAAE
ILHDLGVRSVRLLSNNPDKQLQLEQSGIRVTGVLPWQVGLGKCNHEYLKV
KRDKMGHKIEL
>TWT008 unknown
MKVVLGMGVCYIYGAGEHFTPPEEVGMHDLVIAADGGLMQLKKHGARIDL
YVGDLDSIESIPINIDRVILPREKDKTDMMQAALIGAERGFRTFCIFGGT
GGRLDHTIGNIQLLAELTNMGYSVFIVGKYDVVTAIRNNEIYFPSHFTGN
ISIFPHSGDASGVYEEGLKYALNNAHIPGTFNGVSNEFVGVKSRVAVESG
MLLVVYERQGGRMHLNISTCAMTAGNQIQKPSG
>TWT731 uroporphyrinogen-III synthase-like protein
MRHSCHHVWITRGGQWAREIAGMLKVRGVTSVVHPVIDCVPVMGYENELQ
KIPFFDWLIVTSSTTAGLLNTPIPQSVKVAAVGRETAESLIRAGHRVSLC
PENDFSSDGLASAIQAHLNFPRRTCDSVISQRILILTSDLSEGFLKSALE
RMGHKVTVLVIYKTVILDIPPMPQLDNITAAFVTSGSIAQGIAKTGLFFD
LPLVCIGHKTAEICQRSGLRVASIARTKNKEGLVQALFELS
>TWT565 pantetheine-phosphate adenylyltransferase
MSNRIAVVPGTFDPVTRGHMDILTRTSRIFNTLYVLVANNPDKTPLLPMH
DRVDLVGQALEEYGFPRSEPKCDSESDRNGPIVKIHRFEKGLLVDCCKQL
GATVIVRGLISADAHREASMAYANRNMSGIETVFILPDPPLSVVSSSMVR
QLIALGGDISPYVPACVTRFFGTHSG
>TWT585 unknown
MLLRQRARIMILNRILMLDCHTQNHAEKQSHTENMNKTAALVAALIVFSA
VIAALASQVLSELGYSVFVPSYTFVFACLALALIQIILAIRIKLVLVKGK
RAINPAFAYRILALARSYILAGSLFFGFFSGTALYFVRGGFIPEKFYLLI
PPAIASLIVIIAGVISRFLLRIPKDHGAVANLE
>TWT689 dipeptide ABC transporter substrate-binding-like protein
MRHIPDALNALRAGRPVVVLDDKNRENEADVIMAAQFATQEWVAWIIRHT
SGFLCVPLSNQRADKLQLPSMVAANEDRFKTAYTISVDAADAAITTGISA
ADRSLTIRTLAARDSSAKHLVRPGHILPLRARDGGLLERRGHTEAAIELM
RQAQLEPVAVIAELVSDTGELLRGRALDEFIRKNNLVLVEISQIIEYMKM
SDLKDISMNLNRDCL
>TWT623 unknown
MGGAGLLTDQYELSMVNAARISGIAAKECVFEVYSRALPPGRPFGVFAGL
ERLLEKIENFSFADDEITWLREKNIVDNETLDWLRGYSFSGSISGHKEGE
IFFPNTPVLTVRAPFAEAVVLETLILSCINFDSAIASAAAQLVYRAKNKP
VYEMGSRRTNEQAAVAAARAAYIAGFAATSNLAAGKIWDIPTVGTMGHAF
ILAHKTESEAFYAQLKQGGGNNITLLIDTYDIQEAIDSAVTVAGKNLAAV
RIDSGNLPEVVHDVRRKLDLAGATETKIILTGDLDEASIRLVSTAPVDAL
GVGTSLVTAGGFPSAGFVHKPVACREKNRWRMLSKKSKNKVSTGGQKNVQ
RVLDKNKKIIKEQVLVFDPDNPPVTTYDTNVLQITSEHIRHGKRVAINST
NEIRAYHKSVINQIPEEVFNLEGKINTERISWHSVQGHRLEA
>TWT264 pyridoxine biosynthesis enzyme-like protein
MGLDNLKVGLAQMLKGGVIMDVVTPDQAKIAEDAGAVAVMALEKIPSDIR
ASGGVSRMSDPGLIERVMDSVSIPVMAKVRIGHFAEAQILQSLKVDYIDE
SEVLSVADSSYHIDKRKFTVPFVCGATNLGEALRRISEGASMIRSKGEAG
TGDIAQATKHIRAILSEISALTQAREDELPARARKLGAPIDLVRETARLG
RLPVVLFTAGGIATPADSSLVMQLGSDGVFVGSGIFKSEDPKAYAAAIVQ
ATAQYDDADLLARVSRNLGQAMPGVSNLDVRFSNRGV
>TWT024 birA, biotin acetyl-CoA carboxylase ligase
MFPCVFLDTVGSTNLYLLELLKAKDLDDFFAVFTTNQTAGRGRMARSWEC
KKGIALSVFLKHNLPGAYINWLPLVIGLAVVKAVNKMLEDATLPHRADIK
WPNDVLINGKKLSGILIETPSDGNGLIVGIGLNVAVAPIATSICLRQVGL
QASPKEVVSALLAEMHTIYQQLIALAAKDISFKDSECFGEIMRLCSTINK
TVRVTGTKTFVGVAQGLDSLGRLVIRHSGDTSIVSAGDIEHLRAIDSL
>TWT147 coaA, pantothenate kinase
MGIEVFKKDITKTYTEMLKDIRKRVRERGKVGKSFIIGITGSVAAGKSTL
ASDLAKMLDGISVEVISTDGYLYPNKILEQKGLMLKKGFPESYDTAHLAS
LVKNIKAGAKTIGIRQYAHPIHDVTGVIKTVNKPEILIIEGLNVMRHPVK
TVVDLGIYIEAPKRSVFKWYVKRFFELRAQHEKNTYFRKYANLPRRQCIK
MLKQVWRDVNRKNFTENILPVKHTADFIVYKNPRHKMILYRNEASSSGFP
V
>TWT294 coaE, dephospho-CoA kinase
MVMQLFALTGGIAAGKSCVAGLLSEFGLRVVSADSLVEVLYRTDVRLIEE
IKGRFLCNDEKSLSELVFSDSRARRVLNQLTHQRVNSLALDYFWQLRNEP
VVIYEIPILESTSPFVGFAPGECGVFASGKIQHSGVLFVHSDCESRIDRL
MKRNNLNRIQALQRIHSQTPYMPQYSLRAGDLLRTGGSLRTGDLSHDFRE
ERAPHKGVKVYSVHTSGVSKTLCMIQNTSDFSHLRQCVASVFQIMKTIDR
SV
>TWT361 dfp, flavoprotein
MMQNAIGRIFLGVCGSISAYKSVYLARLFVKEGYDVRVGFTNGASQFVAG
EPFRVFTGHHVLNFPCDDQSHIDISQSHIDISRWADAIVVAPATANILAA
ARAGLASDIVTQTILSSHAPVLFVPSMHTAMWENPATRDNVNCLLERGYH
VLGPVTGDLSSGDWGIGRMVDPCEIVQYVSRSLLNHQTGKLSGKKFLITA
GGTRQPIDPVRYIGNRSSGKQAIAIAKEAQKRSAEVILIAANVEAVTLPT
GMRVITVVTAEEMRKALSDNIDTSDVVIMAAAVSDFQPREVASQKIKSND
GWTLQLISTDDLLRELASNKSRPRVLVGFSAETEESANFRIDIARQKLLS
KGCDYMVVNQVGFDVGFDVSDNEVSLIDDKQVFFTARGSKDYIAKRILDF
LSERVIVTYIDPLDRSL
>TWT058 fepC, iron ABC transporter ATP-binding protein
MYLAGRICFIYLSGEQMITVDKLSFSYGKNKVLHDISIEIKRGSFIAIIG
ANGCGKSTFLRSIAGLNRFEGDILLDKQHIRRLKPKNLAKHIAFLPQQVN
LPEGLTIADLVSRGRYPHQSILHRWTKTDEEVVKESLQAVQASHISQRAI
EAVSGGQRQRALIAMVLAQQTRILLLDEPTTFLDIAYQYEILELLASLNR
ESKTIICSLHDLNQAARYASHLFVMGEGRIIASGEPKKVITENLIENAFG
LKSRIIDDPESNTPMIIPRKSENLKRL
>TWT476 folC, folylpolyglutamate synthase
MSEFYRQIMSRAGEALPQPRLDGTKLALSYLSNPQECAPVIHITGTNGKT
TVSRMIACILTSLGLRVGLFTSPHITALEERIQIDMNPVQGHILEKHWFD
IQFQLRLADAHLEKKNCPPLTFFECMTVLAFSCFADTPVDVMVLEVGMGG
AWDATNVVDARVCVFTPIDFDHTGRLGSRLEEIARTKAGIIKPGSFVVAA
EQHQVVQECLEDYFASINIGCQSYDTELPDKIRFFGQDFDCDYKPVAGGQ
ILDLRGLYGECNEVFLPLFGGYQAKNAALSLAAVESFFGRVEHDIALEAF
SNITSPGRLQIISKNPVVLLDAAHNPHAAKHLAIALDEFFSFGKIVFILA
FLSDKDIEGIIRNLMSFLHGSLRVTSDSVGYSESESTRFSNPRVTFVITQ
STHPRAVAADVAFSIAKRVVANEGLIVCESANDAFQYSTRLNPDAIVVSG
SISILSSFIPR
>TWT634 folD, methylenetetrahydrofolate dehydrogenase NADP+
MVAKVLDGLAVSAGIFERLHRACCELENNGVCPKLATVLVGNNPASRSYV
LSKHRDCKNIGIQSTLIELPANTSEKELISKVEILNASSDVSGIIVQLPL
PESIDQNKVIEAINPDKDADGLHPLNLGYLVTGKQGIVPCTPAGIVKLLE
AHRITLEGKTIAVIGRGTTVGRPLGILLSGKGVNATVINIHSRSRNISGL
SRIADVVVACAGVKHIVEPSWIKPGAVVVDVGINQSGVSSSGKMILTGDV
HPLTKNIASYISPVVGGVGPMTRAMLMSNVINLSERDFRKRLYAS
>TWT587 folE, GTP cyclohydrolase I
MTKLCRFESGSAQSAVANLLSALGQDVGRLKETPSIASSGLESLISGSET
NPADCLVDLIPNTQKGIVILRDIPFRSICEHHLLPFVGTANLLYEPGKFL
AGLGNLTSLVRCAARRLSIQERVTDQIADAIYTGLCARRVLVSLAARHTC
ILDEAGNTEVTTFAHRGIGDADIISFMTIIR
>TWT586 folPXK, dihydropteroate synthase/dihydroneopterin aldolase/2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase fusion protein
MMNMSYTPDPFPPPNVMGILNITDDSFSDGGLFLDPSAAITQGRKLFAEG
ASIIDVGGESTRPGAERISVEEEKKRVLPVVRELLSEGIHVSLDTMNADT
AKEGLSMGVAIINDVSAGKADPDMLRVIADAGCKYIAMHWRGHSMFMDSL
AHYDDVVSDVLRELKFDIERITAAGVKSDQIILDPGFGFSKTSDHNWQLF
RNLDCFVKLGFPVLIGLSRKRFLSRVFKGHDFSPKDSKNVGGLDNREILA
RDLPSGILSAIAITRGAWGVRVHDVASAHTALRTLQLAQYGSVYQAHKRA
ANTGIDTAIPGQGNTDDTTASSNHTNNSETGASLKSGVSQVRNMIAPPVI
KIRSLRVYAYHGVYRSERDYGQQFIIDADIQLKHFPEDKIDSTLDYDSLT
GKFVQYATASSVNLIETLADHLAKIAVLDPMVEWVSLSITKPNPPLAYMK
QSNTAACHAMHKPDTRGDYAKEHTNLTGLQLSCTVRKVRSESVTRVYIGI
GANVGNCLDNVQRAIKDIADHPMIELVSLGRLFRTTAVVGESLDESLPVF
LNTAIAIDTALSMQDLLALMLCIEKKLGRTRHSRTRHSLSSAQDAHQADS
TSDNPNQLHYPCAGRQGIQQPLHSSTLAHTQDGFVNRHIDLDILLAEGVQ
ITEHGLCIPHPRLSKRAFALLPLESIDPDLHIPGHGPITDLIHGLPEDQI
SSVATLRDSGYELFRHSITRLNNCSAHNKAYVTPSAGQNYDSEQDFDAGL
SHTESRGKTEPHGKYE
>TWT054 grcC, probable heptaprenyl diphosphate synthase component II
MLVSGIFLSDILDPSGSLSDDISPALDRVEDLLLETVGDCHEIVSHLLVS
GGKRARPLLVLLTSCMGSGINDAVIRAAAGIELIHLGSLYHDDVMDNAYI
RHGSITAHRLWGKSAAILAGDFLFAKAGVLGLNLDKRAIAVQTEAFQRMI
SGQLSETLGISDSLDPLEAYIEVSRGKTGSLIAASAQVGAILGDASPSTL
EPLRDFGESIGVAFQLVDDVIDLSGKSGKTPGSDIRAGVMSLPILLLSNA
AKDDRDSAVLLEEIERVRRHSGACGSDDYSSEMNAVLAHLRKHDVTARTL
EIARTWGDKAKHALKKLPECAPRDALLAFVETVVSREF
>TWT736 hemA, glutamyl-tRNA reductase (GLUTR)
MLLCVSANHKKTSFTVLEQLARVSPDFASELVEAEDIDGAAILSTCNRFE
VYIDAIQKGDQDDVCKTGLLVQNRIGELCNISPSTIIEQTSFLAGCEVSR
HLFSVATGLESMIIGETEIAGQVKRALTYAQKCRTTSPELERLFQRASAV
NRHIRQSTKINEVGQSLVSLSLDLASSRIGDWSGVRAIIVGTGKYASKAL
ALLKERGVVDISVYSPSGHVNNICNTEGVRNIFNLQTALSGCDLVVGCSS
VDKPVITKQDIETAQASGSRTSRVRPVGRPSTDLTAIEASNRSRHVLIDL
GLPRNFDPAISDLPTADLIDLDMLRVHAPFDNLAAEKMAHELAIESSSQF
VNDCKQHEATPVIVSFRNYLESLTQTSLRRTDNCKHAQHALKHFVNSLIH
IPLTRCKQLAANGESHKFAESMEILFDVKTDCTEGTQYQSSCGKSFD
>TWT730 hemB, porphobilinogen synthase
MGLMFQKIRTRRLRLSEAMRRLASEHVLVPHKLVLPIFVGEGLQPRPIPS
MPGVVQHSIDSFKRELQKAACAKLGGVMLFGIPDSRSEGAEDAFRPDGIL
NKACSIAVREVGDSLLIQTDLCLDEFTQHGHCGVVSKDGSIDNDATLEMY
AEMALAQAAAGSQMLGLSGCMDGQTGFVREVLDSNGNHDVSLVAYSAKYA
SALYGPFRHATNSPFSGSRKTYQLNPANLREAIRKIEVDISEGADALIVK
PAGYYLDVLRCASEISRIPVMAYQVSGEYAMIKSAAAWTDTKQLVIESLL
SIHRAGADAILTYWALDAASWLSETF
>TWT732 hemC, porphobilinogen deaminase
MYPLRIGTRSSLLATAQTAQVQKTMRDVFLLDTQQVLIQTGSVRRRDGSF
VAALRTALLEGECDLAVHSLKDIPIAPHEGTLITAVLPREDPCDVLCARK
DLTLTTLPSGAKVGTASARRRAQILNFRPDLDVVSLRGNIDKRLIHLDTL
DAIVLSAAGLKRIDREDAITESFDIHDWPTAAGQGSLAIEVCRAQLDDPQ
NRVAVTYRLDNPMARVTTTAERGVLSLLQADCFSPIAVHAVYTANDKSLG
LHAKVFSRDGKIFCESIRFARLVKQLTDTNQNHTKNSGSDDIGNALEVAM
TLAKTVVDELLSKNAREILKQ
>TWT735 hemE, uroporphyrinogen decarboxylase
MTGASGVEGTRIPLHSLSCRPSAGRSAGSFVNTGIMEAFRGTRPGCLPVW
FMRQAGRSLPEYRAVRGTNTLLEACLNPDLACEITLQPVRRYSVDAAILF
SDIVVPLKLAGVGVDILPGTGPVLNNPIDTPDRVNTLLAKTADSIDFGII
AEITRHTVSVLNGIPLIGFAGAPYTLACYMVEGGPSKTHMKARAMMHGDK
KTWQKVMMLAARLSGQFLAAQITSGAQAVQIFDSWAGSLSRKDYVDNVAP
FSKMTIDLACGIDGNSDLSKTGKSLWPRVPVLHFAANAGHLLTAIRDIGV
SVMSVDYTKPLDEASELLDDSMPLQGNIDPAMLFAPWEVLKRHVLDIVQR
ASRAPSHVLNLGHGVPPDASCDQLARIVDLAHSMV
>TWT729 hemL, glutamate-1-semialdehyde 2,1-aminomutase
MRTNFEWFEEAKRFIPGGVNSPVRAYAAVGGTPRFLAKAQGAYVTDIEGR
EYVDLVSSWGPLILGHAHPKVIDAVINTAHRGMSYGAPTTLEVELAELVC
NRICNAQGIKPVERLRLVSTGTESCMTAIRLARCFTGRDLIVKFSGHYHG
HADPFLIDAGSGLVGHPSSGGVPESVAKNTLVVPYNDLAVLEYLFEAYPN
QIACIITEACPANMGVIPPDPGFNARVADLGHSHGALIIFDEVITGFRVG
SGGFWALETSLASQQPTQAVSEGSVSDSAYSAYVPDLFTFAKVLGGGLPI
GAIGGRAEIMDLLSPSGPVYQAGTLSGNPLATAAGLATLRLADSNIYEHM
NRVARALINEIQSAFHDAGVPCTVQSAGNLFGISFSAIAPRDFTQATSQE
HWRYSNFFHSMLNSGVLLPPSVYEAWFVSAAFDDRAIERVVNALPDAVRA
AGSAPARPKGFEPPTF
>TWT733 hemZ, ferrochelatase
MIRRSAVSRVVAEGSAIASDSGFALGASQYDAVVLLSFGGPEGPEDVVPF
LKKVTSGRGVPDERLYEVAEHYNHFSGISPINDCNRRLRGALEKELFSRG
IRIPVLWANRNWQPQLEEVLREAYDRGFRAFLTLFTSAYSCYSSCRQYRE
DIAHAVERAGLSGRIIVDKLRQFFDHPGFVLPFIEGIQDCLEQVKERGFK
VSRTAILFSTHSIPELDAAFSGPEDAHFGKYGAYVSQHKAVVEVIMSRLR
VTDPDLQNYQLVYQSRSGDPSTPWLEPDINDAIRVLRGCEAVLIVPLGFI
SDHMEVLWDLDNESMQTARECGLFAIRTPTPGTHPLYISGMVDLIVERLE
GVPRSARPAMTDLGPWFDVCQPGCCKNSRSGFKPAYGGVAP
>TWT217 idsA, geranylgeranyl pyrophosphate synthase
MSVFHVSVFPTRKVPCHCQDKFGCFMTLLEMVNTKISRFILNNKTSKHTE
SMYDYLQDFTFGGKRLRAKLCFTGAECIGPIPENLFELISDIAVAIELFH
AAALVHDDLIDKSDSRRGLPAVHKRFAKFHEENSFVKCKENFGTASAILA
GDMLLVWSSRFFYSALNNLLNTTAKQASDFHLDTMNILWHEMQNEVVIGQ
YMDVLHEHRWRQLSVQEALDISKEIMIKKSGKYSVQVPLCLGANTNGATI
EHLEVLKRFSLPIGLAFQMRNDIDGAFANDKITGKPSSDLSSAKHTMLIG
LARIHSTKHGRIRLEEILGQADNEEEIRAIVTESGALREAENLIKKWTDQ
AMEIIKEARLHSMGKEKLIKIASWLSQAT
>TWT205 ilvB, acetolactate synthase large subunit
MVRISGAQAVIKSLEELGIDLVFGIPGGAILEVYNSLFSSSIRHILVRHE
QGAGHAAEGYACSSGKLGVCLATSGPGATNLVTAIADAYMDSVPILAITG
QVYSHLLGSDAFQESDIIGITMPITKHAFSVKRATEIPAAIFAGAKIATT
GRPGPVLIDITKDAQQDEFDFMWPPKSIDLSGYSVAQNIPDTLAQFADGF
FDMLSGSIRPVIYAGGGTVRSGASEELIRFAEGFGIPVVTTLTARGVLPD
SNRLNLGMPGMHGTVAAILALQKSDLLIALGTRFDDRVTGRLDSFAQNAR
VVHVDIDPAEIGKNRRPDLFVIGDVKEVLGYINSHSENKTTGDLTAWWRS
LEKMRQIYPLVFPQKSSDGNLSPGYVIKRLGELSGPDAIYATGVGQHQMW
ASQAISFSRPNSFLTSGGAGTMGYAVPAAMGAKAANPEKIVWAIDGDGCF
QMTNQELATCSVNGLPIKVAVINNRSLGMVRQWQGLFYNKRYSQTDLNTG
DAYIPDFCKLAESYSCASCRVSSVDEVDNAIEFALAINDRPVVIDFVVCK
DSMVWPMVPQGLGNSHLKYLQDVSPVWHDNE
>TWT207 ilvC, ketol-acid reductoisomerase
MSEIGTRVYTECDADLSLIQNVLVAVIGYGSQGHAQALNLRDSGVNVVIG
LKENSASRKSAQDSGFEVLLPQEAAKKAQLISLLVPDPAQRDVYESAIKH
NLSEGDALLFSHGFNIRYGYITPPDGVDVLMVAPKGPGHMVRREYLDNRG
TPAVFAIEKDASGRCFDLALSYAKGIGALRAGAIQTTFTEETETDLFGEQ
AVLCGGLEQLIQYGYETLVEAGYQPEVAYFEVLHELKLIIDLIVEGGLSK
SRWSISDTAEYGSYVSGPRVIDKHVKENMKKILGEIRSGEFANRFIKDQD
SGANEFTQLREIAARHPIEEVGARLRALFSWSK
>TWT208 ilvE, branched-chain amino acid aminotransferase
MSAKNYKKTLLVNPISQDELQKRLSAPGFGSVFSEHMVSADWHRDLGWHD
YRVEPYGPISLAPSAMVFHYGQEIFEGLKIFRHSQDSSVRAFRPLENAKR
FQKSSERIALPVLPVEDFLQSLREWVMVDGRWVPNAPSCVYARPFMIATE
EALGLRATCSARYTLICCPVGDLFGQIRPIRVRVSSKYSRASRGGTGSVK
FGGNYAASILPQVEAGNDGFDQVLFLDSASYKNIEELSASNIFFVLSSKT
LITPSLGGTILPGVTRDSIIRIAEDLGFVVEQRQISLDEVTHLFSQDKVT
EMFCCGTAASVTPIGSVSFDGGTLGSGQAGPVTMLLREYLRDIQFGNRPD
KYNWMVNLEDT
>TWT464 lipA, lipoic acid synthase
MQNMNDSGNSSKVNVRPPSAGLGAPSPGKRKMLRLEVRNSQVPIERKPSW
IRARATIGTEYRKVQERVKKQNLRTVCQEAGCPNIYECWEDREATFLIGG
SQCTRRCDFCQIDTGKPAELDLDEPKRVGQSVAQMKLRYATVTGVARDDL
PDGGVWLYAETIREIHKQCPGSGVEILIPDFNGKPELLQQIFEAQPEVYA
HNIETVPRIFRRIRPAFRYDRSLDVISQGQKAGMITKSNLILGMGETGEE
VTQALRDLKSAGCDIVTITQYLRPSPRHLPVARWVKPQEFIEYKEQAKEI
GFSGVLAGPLVRSSYRAGKLWAQSVKAKMVEIPERVRKLINEIEMQETSF
RQAV
>TWT463 lipB, lipoate-protein ligase B
MHSNLPGYWLVYSIRVLAIECIRLAPEYLPFEEGWRMQQELHKKITESQT
NKNRQASMIFCEHEPVYTAGARTRSWEMPQNEKVIRVGRGGKITWHGPGQ
LVGYPILSLGATPDVLRYVRQIEEGLINALQSVGINGFRIAGRSGVWVRN
GVSDEKVAAIGVRVQKNVTLHGFALNCSNDLAPFEKIVPCGISDAGVTTI
SRILKRTITPKEILDSVFNSICSALEYINTCRGNV
>TWT070 menA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase
MALEKRRRKKKRSLILPWLLASRPATLIVSLSAVSLGWGAALLTVTGRKA
SLLLVALAALTAVLLQIGANYINDYGDGIRGADSNRSHASRRLTASGANP
FSVLTTGLSFLIAAAGSGLIAVILTQRWQLILVGVFSIAAAYLYTAGPFP
YAYFGLGELSVFIFFGPVTVIGTVFLLSGIVTLSSFLVAVVAGSWSAAIL
LMNNLRDHESDMQSNKRTFSVLFGVLIARIVCIALIAVPYIVVAILLIEL
PFIGYVFLTLLLSAPIVIILATAVTSKEFAIAFRLGIICLIPFAIFFTWG
LAS
>TWT110 menB, naphthoate synthase
MGESKGAPTFDTLQHVLLSELFDPDLWVAHEGFEACDVTYHTAPGVARIA
FNRPEIRNAFRPETVDQLYAALDHARVSDKIGAVLLTGNGPSPRDGIRAF
CAGGDQKTRRRDGYAYSDSHRSSRMHILEVQRLIRFMPKPVIALVNGWAA
GGGHSLHVVCDLSIASLEHAKFKQTDATVASFDSGFGSAYFARQVGQKFA
REVCFLAAEYDAKTALEKGAVNAVVAHEYLEQTGYEWARRILEQSPTSIR
MFKYALNAVDDGLVGQQIFAGEATRLAYATDESKEGRDAFLEKRRPDWSS
FPWSF
>TWT068 menD, 2-oxoglutarate decarboxylase
MTCASGIAFCLLNLLAERGVRDIVVAPGARSQALALAAVALERAGLVRLT
VRIDERVAAFTAFGMAKALDSPAVVITTSGSAVANLYPAVVEASHSFVPL
IVITADRPRELHGKRSNQTMNQEKFFSHWVRFFCHIEQDVPGERVIDSAL
QAALGVSSLRGAGPGPVHINVAFDNPLSCAHAVQPGDNKGSALKHKKVLR
SKRETLVLRKDDPPTVIIAGTGSGRRPADIACATGWPLVAEISSGSRFGP
FLIKNYRNWLTENSLDIRRAIVFGHPTLSSEIPTFLTKRSIDTIVVAPFG
REFYNPSGTARPVANVLVDEDSFSGIPLGAAKFASASAGCISQDVISSDR
PRGHRVTRQQLVSEIWNITKEDEILFFGSSQLIRVADSILPGKRVTVFAN
RGLSGIDGNLSTAAGIAIATNRTTRVLVGDLTGVHDIGALLIPLMEAKYR
LQIVIGNDFGGGIFDTLEVHATPSDYKRVLYVPCRVDFRLVSHAFGWKYT
FCPDPNSLRKALKSRIFPHLLEVHLAV
>TWT052 menF, isochorismate synthase
MNRVTTRVTMLPIEVEITRIGNMDRSDFKRQYIRKVLSWDFVYCTHSTMM
RTQGRVLKINLDSYSAEARFEAAESLINEIHTKIQYTSENLNPIGLIVLF
GFTFSPYSARPSFLAIPEQMFFWSDGVAWKIDATICHNLSEPSRIFKWPK
SISFKMGDFRQEDYKHAITNVVNKLLNADISKVVLARDIIAEIHDDFDPE
AHAIDLDEAIQRLMNTANGTVFVFDGLFGASPEVLLRTDGNSGFEVSILA
GSMSANHPKHVIHNCAASPPYKALDETYLDEKLRLEHSFALNPTLERLST
LMNTAPTVNSYKIRRFTHITHVASFISGTFKPNISPLRALSHIHPTGAIA
GEPRERALEIIKEIEPFDRELYGGAIGWIGQDSSCEFTLPIRCAQLNRGH
IKAFAGCGIVKSSIPQKELEESTLKFKTIIDAIS
>TWT360 metK, S-adenosylmethionine synthetase
MILTSESVTEGHPDKLCDQISDAILDGVICKDKNARAGIETIAGNGVVHV
FGEVSNPDSVDIPGIIRKTILDIGYTSEDAGIDGNTCSIQESITSQSKEI
ADAVNFSLEYRNQQGDLGRNSFSQQGSGDQGSVFGYACRETPEMMPLPIT
IAHKLAYSLAFVRKEKILPYLLPDGKSQVTLGYDSANRPKTLETVVISAQ
HEDSVDLDKLRFDILERVVRPVISATGLDCSKATFLINPAGRFVTGGPSA
DSGLTGRKIVVDTYGCAAKHGGGALSGKDPSKLDRFASYMARWVAKHVVA
ADFAESIEVQISYAIGKAHPVAFNIDTHGTNTIALDKLKRAILKVFDFRP
AAVIDSLDLKRPIYQKTAAYGHFGRDIFTWERICPDKLNALLGAV
>TWT469 nadD, nicotinate-nucleotide adenylyltransferase
MTSTPKTDRGARIGVMGGTFDPIHHGHLVVASEVASRFCLDEVIFVPTGR
PPHKKEVSDPWHRYLMAVIATASNQRFSVSKIDIERTGPTFTVDTLRELR
EQLPSSDLFFITGTDALARIFSWKDADTLWSLAHFVAVSRPGHEVVDIPN
DRISFLEVPAMAISSSNCRERVRSGLPIWYLVPEGVVQYIAKHGLYRSLY
G
>TWT405 nadE, NH(3)-dependent NAD(+) synthetase
MWSRMSRVRVPLSTLSSGSFVCCDISKTLCVKPFIDPEEEISHRVSFLAD
YLRHSRASGYVLGISGGQDSALAGRLCQIAVESVRSIGFDATLWAIRLPY
GQQFDESDAQTAMQFISPDEELSFDIRSATDNLCVDLNRSLGSKISDFNR
GNIKARLRMVVQYAVAAHHDALVVGTDHAAEAVTGFFTKFGDGAADILPL
YGLTKGQGRALLKALGACDSIIEKVPTADLLDDLPCLPDETELGLQYRDI
DAFLEGKPVSEDITMAITERYKSTLHKRMPPITPHSTWWRK
>TWT011 pabA, para-aminobenzoate synthetase component II
MFKVLVIDNHDSFIYTLVNYLQQLGVTTSVVRSDNNCHSVESMLGVHDAA
LISPGPGTPEESGITLSVIRAAYSTSTPLLGVCLGHQALAVAFGGDIGPS
GRIMHGKLVTVRPRPSAIFKDLPTAFTATRYNSLTVTKVPQALRVIARAD
CGEVMALEHRTAPMYGVQFHPESAVSEWGFRILGNWLYISGFNKAPGISR
DLPIVVYNTRVR
>TWT260 panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase
MICMSRKPSPTRRTRIHRFHKGSCGRKLVGLTCYDFSTARVLSDCELDFL
LVGDSASGVIYGYENTGSVCLDEIIYLAAGVVRGAPNSFIIVDLPFGTYE
KSDELAVETAIEVIKRTGASAVKLEGGARMACRISAIVRAGVPVMGHIGF
TPQTINALGGYKIQGRDNADLIYLDAQAVEQAGAFAVVMEMVTEDLAKTI
TSEIKITTIGVGAGRYTDGQLLVINDLIGLSEKKITFAPRYASIDNTVAS
CVKLWRKDVLEGNFPQKDHIPA
>TWT063 panC, pantoate--beta-alanine ligase
MNLKLASSPHELRTCLAGRAFVLVPTMGALHEGHIWLVDMARRCNLPVVV
SIFVNPLQFDDSLDLDTYPRTLEQDLEKLEGKAFAVYSPSVETMYPNGLD
SIRIDPGPIGRILEGAIRPGFFDGILTIVAKLLLQTAPERVFFSKKDAQQ
AFLVRRMVRELAFPVRVEVTGFLRDKFSLPYSSRNRKLGVDAREKAQRLS
QGLLSVVNNGPLTVRDCIDKITDLANSIGVDLGYAQILDENFCEIASDRM
VTRAFHSEACIGLNTPLFLLAARVHGVRVVDNVDLVVV
>TWT688 ribC, riboflavin synthase alpha chain
MFTGLIKNRGVVKDIVRIRGQKSMGAHKNDIAGQITETDSVRKIGVAIPR
QHLVQQPKVGDSVSVNGVCLTVREGHEDVFVFDISQVTADATTINVWDVG
QFVNIEMPLTPSDPIGGHIVQGHVDGVGMIEQIIDNCLRIKIPDSLSLLV
VKSGSIAVDGVSLTVVNVSEQLPSTANVSGNHGKQNCANSWFEINLIPET
LERTTLGGLQVGQFVNLETDVLARHVRRFMSLVNSFS
>TWT392 ribD, 5-amino-6-(5-phosphoribosylamino)uracilreductase
MSKAIQDFISEKYKFPKDDWICANYIQSFSGNLNSDNCTSDSLSNPRDRM
ILHTIREANDAVFVGARTARVENISVKNKPLIVLTNSGNLGGISANRNTI
VIAPKTTETQIRHTIGASVNVIWLDNFGDITRYSQTMGVLIAKAVKSLGF
KRIVCEGGLTLIRMLLSAGAIDELCISIVDKNSTGPRIDTDTLCTPKLTQ
VLVDQEFYKKQRIKSVYTRWVLQNRRGRDEE
>TWT581 ribF, riboflavin kinase
MRVFRSFDCLGRDKRTALTIGKFDGVHLGHRRLLERIVALQNQDTSALVV
TFDRDPKTFFKKDMSFAPLCSLEQKLSLLENCNIPNCLILRFDDELASMS
AEDFVHKVLLEKLNMSSIVIGDGFRFGARGLGDAMLLEKLARELGFYLEV
IPKIQFGKTNISSTLIRKFLSLGQVGNASSCLGRNHVCTGTVVHGKKRGR
ELGFPTANLGKDVSGFIPADGVYIGRIISDRSYPAAVSIGRNPTFGDLEF
SQIEAHALYEDISSLDLYGRRIDVEFIAHLRDTMLYKSIDSLKAAIRSDV
ERCKEYFSTTVG
>TWT687 ribG, diaminohydroxyphosphoribosylaminopyrimidinedeaminase
MYMRSSACTDLFVLAMHRAITIAQHGPVFDRNPQVGCVILDRDYQLISQG
WHMGSGSEHAEIMALRGAKSILSEPYTAVITLEPCSSAGQTGPCVRALLD
AGVKHVVFGVHDPESSGAKVLSEAGVKITYGVLEREVWGLCAKHILPKVR
KTPWVIAKRAQGLDGRMSAPDGSSKWITGPYARGHAHVIRSQVDAIAIGS
NTLCCDNPSLRAFHPAGHLYAKQPKVVIFSGRPRRSNTAGRGSCELGRCV
RGHEVFARDPTILSGKDLKKDMRRLYELGVRSLLLEGGPTLLSSFVREDL
VDEFYIYTAPKLLGGGYGDINIGVESISDSFAFQLNSVTRFGDNNLLIRA
IKPIQCNPDTRTYRTKKHLQD
>TWT691 ribH, riboflavin synthase beta chain
MGKDRNLSLNSPESIQSVIGDTDIKIAVIAAMWHEKIVRGLIDGATREIV
SSGSHAELFRVPGSVELVLACKKLLKTFDAAVALGVILRGETDHNTHIAR
LVLSGITDVMLALEKPIGIGVLTIDTEQQGLDRSSGDYNAGVNAARAVIR
MVRLFR
>TWT386 trpE, anthranilate synthase component I
METIVEEDRGVFWVDYPVDLSEDFADSCFRYLFEALFYDSENCFWLDDAR
PLQNRRRSAIGSGPSVSLRSGSCLDPTDVESFFSKLLDCDPQPWPLGFVG
WIDYEVGACLLGVNYPTQQDAPATGQTNLSSWICCNRAICIDYRMGLLKI
ISFSKNTVDAKEWVNRASTLVEKLLMKGSIDREDYIPQAKSRHLANSKLM
PRNSFASGLQWLHTDQQYLQLIHRVLEKIMRGDVYQICLANRLTIRNSGN
RSPFSAFWALRQKSPTQYCAYIKIGPRHFVSSSPELFLALSDNILVTEPI
KGTRPRGRSPSEDSYLISELKTSEKEKAENLMIVDLMRNDFSKICSSVEV
DYMYRVRTYKGLHQLVSRVSGILRPGRGFFDILCATFPAGSVTGAPKIAA
VKSIYDLERARRGVYSGAFGYISGDGKNICFAMSIRSAVFCNGEVSIGSG
GGVVFDSDPEFELAETKLKVAAMIDAILGR
>TWT053 ubiE, ubiquinone/menaquinone biosynthesis methyltransferase
MGTNIHIDMVIHGKHTAEIRKMFNRVAQAYDRTNLVLSFLQDAHWRRAAC
KMLGVTAGEEVLDVGAGTGASTRTVARTGAAVTGIDISPRMLQIARNRCK
RFQNITWRLTNGDLPFPDKSFDAILMVFCLRNVSNIQGFLCDAARVLKPG
GRLVVCEFSHPRRFVAPFYRLYLRYVLPRLAKLISSDPAAYEYLTESIED
WYEVDELAFMLEQCGFQNTSWKRLSFGAVALHRALRGPE