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# Streptococcus pneumoniae TIGR4, TIGR4; ATCC BAA-334

>SP_0175 6,7-dimethyl-8-ribityllumazine synthase
MNTYEGNLVANNIKIGIVVARFNEFITSKLLSGALDNLKRENVNEKDIEV
AWVPGAFEIPLIASKMAKSKKYDAIICLGAVIRGNTSHYDYVCSEVSKGI
AQISLNSEIPVMFGVLTTDTIEQAIERAGTKAGNKGSECAQGAIEMVNLI
RTLDA
>SP_1598 putative phosphomethylpyrimidine kinase
MKNNRILALSGNDIFSGGGLSADLATYTLNGLHGFVAVTCLTALTEKGFE
VFPTDDTIFQHELDSLRDVEFGGIKIGLLPTVSVAEKALDFIKQRPGVPV
VLDPVLVCKETHDVAVSELCQELIRFFPYVSVITPNLPEAELLSGQEIKT
LEDMKTAAQKLHDLGAPAVIIKGGNRLSQDKAVDVFYDGQTFTILENPVI
QGQNAGAGCTFASSIASHLVKGDKLLPAVESSKAFVYRAIAQADQYGVRQ
YEANKNN
>SP_0971 putative kinase
MGKIIGITGGIASGKSTVTNFLRQQGFQVVDADAVVHQLQKPGGRLFEAL
VQHFGQEIILENGELNRPLLASLIFSNPDEREWSKQIQGEIIREELATLR
EQLAQTEEIFFMDIPLLFEQDYSDWFAETWLVYVDRDAQVERLMKRDQLS
KDEAESRLAAQWPLEKKKDLASQVLDNNGNQNQLLNQVHILLEGGRQDDR
D
>SP_1859 putative transporter
MMHTYLQKKIENIKTTLGEMSGGYRRMVAAMADLGFSGTMKAIWDDLFAH
RSFAQWIYLLVLGSFPLWLELVYEHRIVDWIGMICSLTGIICVIFVSEGR
ASNYLFGLINSVIYLILALQKGFYGEVLTTLYFTVMQPIGLLVWIYQAQF
KKEKQEFVARKLDGKGWTKYLSISVLWWLAFGFIYQSIGANRPYRDSITD
ATNGVGQILMTAVYREQWIFWAATNVFSIYLWWGESLQIQGKYLIYLINS
LVGWYQWSKAAKQNTDLLN
>SP_0289 dihydropteroate synthase
MSSKANHAKTVICGIINVTPDSFSDGGQFFALEQALQQARKLIAEGASML
DIGGESTRPGSSYVEIEEEIQRVVPVIKAIRKESDVLISIDTWKSQVAEA
ALAAGADLVNDITGLMGDEKMAYVVAEARAKVVIMFNPVMARPQHPSSLI
FPHFGFGQTFTEKELADFETLPIEDLMVAFFERALARAAEAGIAPENILL
DPGIGFGLTKKENLLLLRDLDKLHQKGYPIFLGVSRKRFVINILEENGFE
VNPETELGFRNRDTASAHVTSIAARQGVEVVRVHDVASHRMAVEIASAIR
LADEAENLDLKQYK
>SP_1230 conserved hypothetical protein
MKILVTSGGTSEAIDSVRSITNHSTGHLGKIITETLLSAGYEVCLITTKR
ALKPEPHPNLSIREITNTKDLLIEMQERVQDYQVLIHSMAVSDYTPVYMT
GLEEVQASSNLKEFLSKQNHQAKISSTDEVQVLFLKKTPKIISLVKEWNP
TIHLIGFKLLVDVTEDHLVDIARKSLIKNQADLIIANDLTQISADQHRAI
FVEKNQLQTVQTKEEIAELLLEKIQAYHS
>SP_1231 flavoprotein
MANILLAVTGSIASYKSADLVSSLKKQGHQVTVLMTQAATEFIQPLTLQV
LSQNPVHLDVMKEPYPDQVNHIELGKKADLFIVVPATANTIAKLAHGFAD
NMVTSTALALPSHIPKLIAPAMNTKMYDHPVTQNNLKTLETYGYQLIAPK
ESLLACGDHGRGALADLTIILERIKETIDEKTL
>SP_0724 putative hydroxyethylthiazole kinase
MQEFTNPFPIGSSSLIHCITNEISCEMLANGILALGCKPVMADDSREVLD
FTKQSQALFINLGHLSAEKEKAIRMAASYANQSSLPMVVDAVGVTTSSIR
KSLVKDLLDYRPTVLKGNMSEIRSLVGLKHHGVGVDASAKDQETEDLLQV
LKDWCQTYPGMSFLVTGPKDLVVSKNQVAVLGNGCTELDWITGTGDLVGA
LTAVFLSQGKTGFEASCLAVSYLNIAAEKIVVQGMGLEEFRYQVLNQLSL
LRRDENWLDTIKGEVYE
>SP_1421 conserved hypothetical protein
MYPDDSLTLHTDLYQINMMQVYFDQGIHNKKAVFEVYFRQQPFKNGYAVF
AGLERIVNYLEDLRFSDSDIAYLESLGYHGAFLDYLRNFKLELTVRSAQE
GDLVFANEPIVQVEGPLAQCQLVETALLNIVNYQTLVATKAARIRSVIED
EPLMEFGTRRAQEMDAAIWGTRAAVIGGANGTSNVRAGKLFDIPVLGTHA
HALVQVYGNDYEAFKAYAATHKNCVFLVDTYDTLRIGVPAAIQVARELGD
QINFMGVRIDSGDIAYISKKVRQQLDEAGFTEAKIYASNDLDENTILNLK
MQKAKIDVWGVGTKLITAYDQPALGAVYKIVAIEDETGQMRNTIKLSNNA
EKVSTPGKKQVWRITSREKGKSEGDYITYDGVDISDMTEIKMFHPTYTYI
KKTVRNFDAVPLLVDIFKEGILVYNLPSLTDIQDYARKEFDKLWDEYKRV
LNPQHYPVDLARDVWQDKMDLIDKMRKEALGEGEEE
>SP_1409 putative oxygen-independent coproporphyrinogen III oxidase
MQKKPTSAYVHIPFCTQICYYCDFSKVFIKNQPVDSYLEHLLEEFRSYDI
EKLSTLYIGGGTPTALSAPQLEVLLNGLTKNLDLSVLEELTIEANPGDLD
ADKIAVLKNSAVNRVSLGVQTFDDKMLKKIGRSHLEKDIYENIDRLKLAG
FDNISIDLIYALPGQTMEQVKENVAKAIGLDIPHMSLYSLILENHTVFMN
RMRRGKLPLPKEELEAEMFEYIIAELERAGFEHYEISNFSKPGFESRHNL
MYWDNAEYYGIGAGASGYVNGVRYKNHGPIRHYLSAVEEGNACITEDHLS
QKEQMEEEMFLGLRKKSGVSMARFEEKFGQSFAGLYGEIVRDLVQQGLMQ
IEGDHVRMTKRGLFLGDTVAERFILE
>SP_1746 conserved hypothetical protein
MSYQDYINCSREALLEKMAELLPEKRLTHCLGVERAAMELAQRFGVDVEK
ASLAGLLHDYAKKLSDQEFLVLIDRYQLDPDLKNWGNNVWHGMVGIYKIQ
EDLDLHDSEILRAIEIHTVGAGQMTDLDKVIYVADYIEHNRAFPGVDVAR
EIASLSLNKAVAYETARTVEYLAHQGFPIYPQTLETYNAFVHYLKED
>SP_1160 putative lipoate-protein ligase
MKYIINHSNDTAFNIALEEYAFKHLLDEDQIFLLWINKPSIIVGRHQNTI
EEINRDYVRENGIEVVRRISGGGAVYHDLNNLNYTIISKEDENKAFDFKS
FSTPVINTLAQLGVKAEFTGRNDLEIDGKKFCGNAQAYINGRIMHHGCLL
FDVDLSVLANALKVSKDKFESKGVKSVRARVTNIINELPKKITVEKFRDL
LLEYMKKEYPEMTEYVFSEEELAEINRIKDTKFGTWDWNYGKSPEFNVRR
GIKFTSGKVEVFANVTESKIQDIKIYGDFFGIEDVAAVEDVLRGVKYERE
DVLKALKTIDITRYFAGISREEIAEAVVG
>SP_0165 flavoprotein
MDKKNLLVLVTGSVGASNVDTYLYYIKKFYNVKVILSENSKKFISKELIS
YFCDKVYDEIFVEEVVPHVFLPYESDLLLILPATANVIGKIANGIADDLV
TATVLNFNKKIIFCPNMNSTMWDNHIVQRNVSILKELGHIFLFESKKTYE
VGLRKAIDSTCSMLQPQSLVKELIKLENIVLEEGH
>SP_0197 putative dihydrofolate synthetase
MFEVEEWLHSRIGLNFRSGLGRMQQAVDLLGNPEQSYPIIHVTGTNGKGS
TIAFMRELFMGHGKKVATFTSPHIVSINDRICINGQPIADADFIRLTDQV
KEMEKTLLQTPAQLSFFELLTLVAFLYFREQEVDLVLLEVGIGGLLDTTN
VVTGEFAVITSIGLDHQETLGDSLEAIAEQKAGIFKAGKKAVIAKLPPEA
RLACQKKAESLAVNLYQAGQDFLMLNGDFSSSLLNLSQLNIGLEGVYQQE
NAALALQTFLLFMRERKEAVDEQAVRKALEQTHWAGRLERIRPQIYLDGA
HNLPALTRLAEFIKEKEQEGYRPQILFGSLKRKDYQGMLGYLTEKLPQVE
LKVTGFDYQGALDERDVTGYDIVSSYREFISDFEERADAQDLLFVTGSLY
FISEVRGYLLDREQIN
>SP_1110 macrolide-efflux protein
MIITIPIKNQKDIGTPSDSVVVLGYFDGIHKGHQELFRVANKAARKDLLP
IVVMTFNESPKIALEPYHPDLFLHILNPAERERKLKREGVEELYLLDFSS
QFASLTAQEFFATYIKAMNAKIIVAGFDYTFGSDKKTAEDLKNYFDGEVI
IVPPVEDEKGKISSTRIRQAILDGNVKEAGKLLGAPLPSRGMVVHGNARG
RTIGYPTANLVLLDRTYMPADGVYVVDVEIQRQKYRAMASVGKNVTFDGE
EARFEVNIFDFNQDIYGETVMVYWLDRIRDMTKFDSVDQLVDQLKADEEV
TRNWS
>SP_2095 5-formyltetrahydrofolate cyclo-ligase family protein
MKSELRKQVLHEMKAISQEQKQAIDQALTERLLQHPFYQEAKVIATYLSF
SHEFQTQELIEQALKDGKKVLIPKTYPKGRMDFVVYDPQQLVKTFFALLE
LQGDLEVVDASQIDLIHVPGLAFTTKGYRIGYGGGYYDRYLEHFSGRTLS
TIYPCQIQDFIPENHDIPVQEVLIDEGNL
>SP_0695 HesA/MoeB/ThiF family protein
MYGVRKLIVADYDIIEPSNLNRQILYTESDVGKEKINVLSEKIHKYNSDV
QVVPISIKVSSVEELEKIVAEYGSIDFIVKAIDTPIDIIKIVNQFAVSHK
ISYISGGFNGCYLIIDNIYIPTIGSCFGCRNINKDINKYTLSDKTKWPTT
PEMPAILGGIMTNLIIKIFLGCYNEILIDNAYVYNMRNHALSQEKYVLEN
GECPICKKIIK
>SP_1470 putative thiamine biosynthesis protein ApbE
MTLRSHSERLMGTTITISLVDEQADIFLQKSFDLLKELEYRFNANSQESE
LMEINYQAGIAPVTVHPDLFELISLGLEHSLALSSHLNISIGPLIQTWRI
GFSDAKVAQPQEIESVLPLINPHGIELDSSTSTVFLKQKGMKIDLGCLAK
GYSADKVAQFLRKEGVTSALINLGGNILTIGKNQARGDNPWQIGIQDPAN
PRGNHLMTIPVVNKSVVTSGIYERHLTVDGQDYHHIFDSQTGYPVETELA
SLTIISDKSVDGEIWTTRLFGERPASILWQVESLEGIEVILIDKEGHLSC
SSGIPTL
>SP_1468 pyridoxine biosynthesis protein
MTENRYELNKNLAQMLKGGVIMDVQNPEQARIAEAAGAAAVMALERIPAD
IRAAGGVSRMSDPKMIKEIQEAVSIPVMAKVRIGHFVEAQILEAIEIDYI
DESEVLSPADDRFHVDKKEFQVPFVCGAKDLGEALRRIAEGASMIRTKGE
PGTGDIVQAVRHMRMMNQEIRRIQNLREDELYVAAKDLQVPVELVQYVHE
HGKLPVVNFAAGGVATPADAALMMQLGAEGVFVGSGIFKSGDPVKRASAI
VKAVTNFRNPQILAQISEDLGEAMVGINENEIQILMAERGK
>SP_2067 hypothetical protein
MSCSIDLLKHRYLKNIKENPELFVGIELEYPVASLEGDATDVEVMKDLFH
YLVSTLDLTVAKVDDFGNLIQLVDPISQDAILFEVSYTTIEFAFGKAETI
QEVENRFNNYMNVIQRKLAESNHAIVGCGIHPNWDKNENCPVAYPRYQML
MDYLNLSRNIIKSDLHHFPEYGTFICGSQVQLDISKTNYLRVINAFTQIE
AAKAYLFANSEFSGADWDTKISRDIFWEESMHGIYPENVGVNARLLNDET
DFFDYLNHSAIFTAERDGQTYYFYPIQAGDYLATSEIQAFALNGDEVIIY
PQEKDFETHRSYQYQDLTTRGTVEFRSVCTQPLDRTFASAAFHLGLLVNL
DKLEAYLETAPFFKVFGYDYKSLRRQFSKKNLTDEEETTIIEFSKDLLLL
AEEGLVVRNKEEMTYLQPLREELSL
>SP_0665 chorismate binding enzyme
MHRKTVIDFRTLGERYTFTQPIKELKTRNVEEVADLLAQVESYQEQGYYV
VGYVSYEAAPAFEEKLAVHKDPLLGEYLLYFTVHDIVETSPIPLTYEDID
LPSNWQEVTSAADYEKAIAQIHHHLRQGDTYQVNYTVQLKQKLNANPFAI
YNRMVVEQEAGYNAYVEHDEMTVISMSPELFFEQNDRELTTRPMKGTTQR
GVTDQEDLEQASWLEQDPKNRSENMMIVDLLRNDMNRISEVGSEHVERLC
QVEQYSTVWQMTSTIKSQLREDVDLVEIFRSLFPCGSITGAPKIATMEII
KDLEPQPRGVYCGTIGLLLPNGRRIFNVAIRTIQLHKGQAIYGVGGGITW
DSTWESEYREVHQKAAVLYRKQARFQLITTGKISQKQLMFEEQHLERLRK
ASRYFAFPFDAEDLGHKIEEECQDCEANRDYRLRISLSKSGEIEVNRQVL
TPLSTSFCQAQVCLQEAALNQSFTYFKTTHRPHLSLGEQEKIYHNKSGEL
LETSIGNLVLKIAGKLYTPPIRLGILPGIYRQHLLETGQVEEKVLTLADL
TQAEAIYGCNAVRGLYELSLEEN
>SP_1035 iron-compound ABC transporter, ATP-binding protein
MKGLWSNNLTCGYDEKIILENINIKIPEEKISVIIGSNGCGKSTLIKTLS
RLIKPLEGEVLLDNKSINSYKEKDLAKHIAILPQSPIIPESITVADLVSR
GRFPYRKPFKSLGKDDLEIINRSMVKANVEDLANNLVEELSGGQRQRVWI
ALALAQDTSILLLDEPTTYLDISYQIELLDLLTDLNQKYKTTICMILHDI
NLTARYADYLFAIKEGKLVAEGKPEDILNDKLVKDIFNLEAKIIRDPISN
SPLMIPIGKHHVNS
>SP_1747 conserved hypothetical protein
MTIELLTPFTKVELEPEIKEKKRKQVGILGGNFNPVHNAHLIVADQVRQQ
LGLDQVLLMPEYQPPHVDKKETIPEHHRLKMLELAIEGIDGLVIETIELE
RKGISYTYDTMKILTEKNPDTDYYFIIGADMVDYLPKWYRIDELVDMVQF
VGVQRPRYKVGTSYPVIWVDVPLMDISSSMVRDFLAQGRKPNFLLPQPVL
DYIEKEGLY
>SP_1934 hypothetical protein
MTSRVFIDADCISVFLWVGTEHLLEKLYLGKIVIPQEVYDEINIPTIPHL
KSRIDQLVAKGSAEIVSIDIGTEEYALYRDLTRNHDSNKIIGKGEGASIS
LAKKHNGILGSNNLRDVKSYVEEFSLEYMTTGDILIEAFKA
>SP_1982 thiamine pyrophosphokinase
MSLREKSMSEYKLSENNWTRVAVFAGGNRGHYRTDFDAFVGVDRGSLWVL
EEDLPLALAVGDFDSVTEEERQVIQKGAQYFVQARPEKDDTDLELALLTI
FEQNPQAQVTIFGALGGRIDHMLANVFLPSNPKLAPYMHQIEIEDGQNLI
TYCPEGISQLEPRSDYDYLAFMPVRDSQLTILGAKYELTEENFFFKKVYA
SNEYIDREVSVTCPDGYVVVLHSKDRR
>SP_2019 ABC transporter, ATP-binding protein, truncation
MKGKEYENRTVSFAISSKGEKMKVENISYRVDHRKLFDNISFDTSSSDVT
LITGKNGTGKSTLL
>SP_1467 conserved hypothetical protein
MKIGILALQGAFAEHAKVLDQLGVESVELRNLDDFQQDQSDLSGLILPGG
ESTTMGKLLRDQNMLLPIREAILSGLPVFGTCAGLILLAKEITSQKESHL
GTMDMVVERNAYGRQLGSFYTEAECKGVGKIPMTFIRGPIISSVGEGVEI
LATVNNQIVAAQEKNMLVSSFHPELTDDVRLHQYFINMCKEKS
>SP_1900 birA, BirA bifunctional protein
MKSYQAVYQILSKETDYISGEKIAEKLSLSRTAIWKAIKRLEQEGIEIDS
IKNRGYKLMNGDLILPEILEENLPIKVSFKPETKSTQLDAKEAIDLGHEA
NTLYLASYQTAGRGRFQRSFYSPQGGIYMTLHLKPNLPYDKLPSYTLLVA
GAVYKAIKNLTLIDVDIKWVNDIYLNNHKIGGILTEAMTSVETGLVTDII
IGVGINFTIKDFPQELKEKAASLFKATAPITRNELIIEIWRAFFETPAEE
LLYLYKKQSFILGKEVTFTLEQKDYKGLAKDISENGKLLVQCDNGKEIWL
NSGEISLNSWK
>SP_0839 coaA, pantothenate kinase
MTNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISLQDVTDI
YLPLAHLIQIYKRTKEDLAFSKGIFLQRESKSQPFIIGVSGSVAVGKSTT
SRLLQILLSRTFTDATVELVTTDGFLYPNQTLIEQGILNRKGFPESYDME
ALLNFLDRIKNGQDVDIPVYSHEVYDIVPEEKQSVKAADFVIVEGINVFQ
NPQNDRLYITDFFDFSIYVDAGVDDIESWYLDRFLKMLSLAQNDPDSYYY
RFTQMPIGEVESFAHQVWISINLTNLQNYIEPTRNRAEVILHKSKNHEID
EIYLKK
>SP_1968 coaD, phosphopantetheine adenylyltransferase
MSDKIGLFTGSFDPMTNGHLDIIERASRLFDKLYVGIFFNPHKQGFLPLE
NRKRGLEKAVKHLGNVKVVSSHDKLVVDVAKRLGATCLVRGLRNASDLQY
EASFDYYNHQLSSDIETIYLHSRPEHLYISSSGVRELLKFGQDIACYVPE
SILEEIRNEKKD
>SP_1571 folA, dihydrofolate reductase
MTKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTF
DGMGRRLLPKRETLILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYII
GGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAK
DEKNPYDFTIQYRKRKEV
>SP_0290 folC, dihydrofolate synthetase
MKEIENNQWIANYRTDQPHFGLERMVELLALRGNPHLKLKVLHIGGTNGK
GSTIAFLKKMLEKLGLRVGVFSSPYLIHYTDQISINGESISEARLEALMA
DYQSLLEGEAVANLQGTTEFEIITALAYDYFASEQVDVAIMEVGMGGLLD
STNVCQPILTGITTIGLDHVALLGDTLEVIAEQKAGIIKQGMPLVTGRIA
PEALAVIDRIAEGKDAPRLAYGTDYQVRHQESVVTGEVFDYTSAVRQGRF
QTSLLGLYQIENAGMAIALLDTFCQEDGRELASNDFLGQALEETSWPGRL
EIVSRDPLMILDGAHNPHAIKALLVTLQERFADYHKEILFTCIKTKALED
MLDLLGAMPVTELTLTHFADSRATDENVLKEAAKSRNLSYQDWHDFLEQN
LTDKKEEKQTVRIVTGSLYFLSQVRAYLMERKNENGYTKD
>SP_0825 folD, methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase
MTQIIDGKALAAKLQGQLAEKTAKLKEETGLVPGLVVILVGDNPASQVYV
RNKERSALAAGFRSEVVRVPETITQEELLDLIAKYNQDPAWHGILVQLPL
PKHIDEEAVLLAIDPEKDVDGFHPLNMGRLWSGHPVMIPSTPAGIMEMFH
EYGIDLEGKNAVVIGRSNIVGKPMAQLLLAKNATVTLTHSRTHNLSKVAA
KADILVVAIGRAKFVTADFVKPGAVVIDVGMNRDENGKLCGDVDYEAVAP
LASHITPVPGGVGPMTITMLMEQTYQAALRTLDRK
>SP_0291 folE, GTP cyclohydrolase I
MDTQKIEAAVKMIIEAVGEDANREGLQETPARVARMYQEIFSGLGQTAEE
HLSKSFEIIDDNMVVEKDIFFHTMCEHHFLPFYGRAHIAYIPDGRVAGLS
KLARTVEVYSKKPQIQERLNIEVADALMDYLGAKGAFVVIEAEHMCMSMR
GVRKPGTATLTTVARGLFETDKDLRDQAYRLMGL
>SP_1009 hemH, ferrochelatase
MKKAILMMTFGSPEEIIFEGVADFFTNIRRGVRPQDHEIQTLYDNYVRIG
GTPLQKITRQEVALVEARLGSEYSVYFANKFSSPFIPDVIGQMEADGIEQ
CICLILEPHYSFYSVMGYEKFLESKQIQFLVIKDWYQEEALLNYWADEIA
KILKEEVKQDSFKVIFSAHSVPIFALDFGDPYIDQIFENSKLVAEKLGLS
SEQYTNTWQSESDIGIPWIKPDVLEYLREQTEHPDHYIFVPISFISEHIE
VLFDNDVECYDLCQEFGVNYHRPPMPNTDSRLIDALVNTVRVNENQEFKE
FLPEEETFDELVPSDETKNILAESQDLQMPEFVKKLIEKKGRENVKMPYL
IKKMLEKAGKLPKE
>SP_0445 ilvB, acetolactate synthase, large subunit, biosynthetic type
MEKISLESPKTGSDLVLETLRDLGVDTIFGYPGGAVLPFYDAIYNFKGIR
HILGRHEQGCLHEAEGYAKSTGKLGVAVVTSGPGATNAITGIADAMSDSV
PLLVFTGQVARAGIGKDAFQEADIVGITMPITKYNYQVRETADIPRIITE
AVHIATTGRPGPVVIDLPKDISALETDFIYSPEVNLPSYQPTLEPNDMQI
KKILKQLSKAKKPVLLAGGGISYAEAATELNEFAERYQIPVVTSLLGQGT
IATSHPLFLGMGGMHGSFAANIAMTEADFMISIGSRFDDRLTGNPKTFAK
NAKVAHIDIDPAEIGKIISADIPVVGDAKKALQMLLAEPTVHNNTEKWIE
KVTKDKNRVRSYDKKERVVQPQAVIERIGELTNGDAIVVTDVGQHQMWTA
QYYPYQNERQLVTSGGLGTMGFGIPAAIGAKIANPDKEVVLFVGDGGFQM
TNQELAILNIYKVPIKVVMLNNHSLGMVRQWQESFYEGRTSESVFDTLPD
FQLMAQAYGIKNYKFDNPETLAQDLEVITEDVPMLIEVDISRKEQVLPMV
PAGKSNHEMLGVQFHA
>SP_0447 ilvC, ketol-acid reductoisomerase
MEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGRDVIIGVRPGKSF
DKAKEDGFDTYTVAEATKLADVIMILAPDEIQQELYEAEIAPNLEAGNAV
GFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTYEEGFGVPALYAVY
QDATGNAKNIAMDWCKGVGAARVGLLETTYKEETEEDLFGEQAVLCGGLT
ALIEAGFEVLTEAGYAPELAYFEVLHEMKLIVDLIYEGGFKKMRQSISNT
AEYGDYVSGPRVITEQVKENMKAVLADIQNGKFANDFVNDYKAGRPKLTA
YREQAANLEIEKVGAELRKAMPFVGKNDDDAFKIYN
>SP_0856 ilvE, branched-chain amino acid aminotransferase
MTVTIDWENLGFSYMKLPYRYLAHFKNGQWDQGELTEDATLHISESSPSL
HYGQQAFEGLKAYRTKDGSVQLFRPDENAKRLQRTCDRLLMPQVPTDMFV
EACKAVVRANEEYVPPYGTGGTLYLRPLLIGVGDIIGVKPAEEYIFTIFA
MPVGNYFKGGLVPTNFLIQDEYDRAAPNGTGAAKVGGNYAASLLPGKMAK
SRHFSDVIYLDPSTHTKIEEVGSANFFGITADNEFVTPLSPSILPSITKY
SLLYLAEHRLGLTPIEGDVPIDNLDRFVEAGACGTAAVISPIGGIQHGDD
FHVFYSETEVGPVTRKLYNELTGIQFGDIEAPEGWIVKVD
>SP_1205 ispA, geranyltranstransferase
MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRPFLLLEV
LEALQVTIKPAHAQVATALEMIHTGSLIHDDLPAMDDDDYRRGRLTNHKK
FGEAMAILAGDALFLDSYALIAQADLPSQIKVDLIANLSLASGSLGMVAG
QVLDMEGEHQHLSLEELQTIHANKTGKLLAYPFQAAAIIAELSPEMQVKL
KTVGELIGLAFQVRDDVLDVTASFEEIGKTPQKDLQAEKSTYPALLGLEE
SIAFCNQTLDQANEKLEEIAQQLPFETESIVSVVESLRING
>SP_0762 metK, S-adenosylmethionine synthetase
MSERKLFTSESVSEGHPDKIADQISDAILDAILAKDPEAHVAAETAVYTG
SVHVFGEISTNAYVDINRVVRDTIAEIGYTNTEYGFSAETVGVHPSLVEQ
SPDIAQGVNEALEVRGNADQDPLDLIGAGDQGLMFGFAVDETEELMPLPI
ALSHKLVRRLAELRKSGEISYLRPDAKSQVTVEYDENDRPVRVDTVVIST
QHDPEATNEQIHQDVIDKVIKEVIPSSYLDDKTKFFINPTGRFVIGGPQG
DSGLTGRKIIVDTYGGYSRHGGGAFSGKDATKVDRSASYAARYIAKNIVA
ADLAKKAEVQLAYAIGVAQPVSVRIDTFGTGTVAESQLEKAARQIFDLRP
AGIIQMLDLKRPIYRQTSAYGHMGRTDIDLPWERLDKVDALKEAVK
>SP_2016 nadC, nicotinate-nucleotide pyrophosphorylase
MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKE
AGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRS
LLTCERVALNFLQHLSGIASMTAAYVEALGDDCIKVFDTRKTTPNLRLFE
KYAVRVGGGYNHRFNLSDAILLKDNHIAAVGSVQKAIAQARAYAPFVKMV
EVEVESLAAAEEAAAAGADIIMLDNMSLEQIEQAITLIAGRSRIECSGNI
DMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV
>SP_1420 nadE, NH(3)-dependent NAD(+) synthetase
MSLQETIIQELGVKPVIDAQEEIRRSIDFLKRYLKKHPFLKTFVLGISGG
QDSTLAGRLAQLAMEELRAETGDDSYKFIAVRLPYGVQADEADAQKALAF
IQPDVSLVVNIKESADAMTAAVEATGSPVSDFNKGNIKARCRMIAQYALA
GSHSGAVIGTDHAAENITGFFTKFGDGGADILPLYRLNKRQGKQLLQKLG
AEPALYEKIPTADLEEDKPGLADEVALGVTYAEIDDYLEGKTISPEAQAT
IENWWHKGQHKRHLPITVFDDFWE
>SP_0963 pyrK, dihydroorotate dehydrogenase, electron transfer subunit
MKVVAQEEIAPAIFELVLEGEMVEAMRAGQFLHLRVPDDAHLLRRPISIS
SIDKANKQCHLIYRIDGAGTAIFSTLSQGDTLDVMGPQGNGFDLSDLDEQ
NQVLLVGGGIGVPPLLEVAKELHERGVKVVTVLGFANKDAVILKTELAQY
GQVFVTTDDGSYGIKGNVSVVINDLDSQFDAVYSCGAPGMMKYINQTFDD
HPRAYLSLESRMACGMGACYACVLKVPENETVSQRVCEDGPVFRTGTVVL
>SP_0176 ribAB, 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
MEYRKIQEALEALQKGRLVLVIDDKDRENEGDLICSAQAATTENVNFMAT
YAKGLICMPMSESLANQLMLSPMVENNTDNHKTAFTVSIDYKETTTGISA
EERGLTARMCVAEDITPSDFRRPGHMFPLIAKKGGVLERNGHTEATVDLL
KLAGLKECGLCCEIMNHDGKMMRTDDLIQFSKKHNIPLITIKELQEYRKV
YDQLVERVSTVNMPTRYGNFKAISYIDKLNGEHHLALIMGNIEDEANVLC
RVHSECLTGDVLGSLRCDCGQQFDKAMKMIVENGSGVLLYLRQEGRGIGL
INKLKAYHLQDQGMDTLDANLALGFEGDLREYHIGAKMLKDLGLQSLHLL
TNNPDKVEQLEKYGITISSRISIEIEANPYDSFYLETKKNRMGHILNMEE
K
>SP_0178 ribD, riboflavin biosynthesis protein RibD
MSDSKYMKLAIKLAQKGAGYVNPNPMVGAVIVKDNHIIGQGYHEFFGGPH
AERNALKNCRESPVGATLYVTLEPCCHFGKTPPCIDAIIDSGITRVVIGS
LDCNPIVSGKGVKILEENNLQVTVGILENECLNLIKSFRKYITQHVPYVF
MKYAMSMDGKIATKTNQSKWITEEEARKHVHQLRHHVSAIMVGVNTVIQD
DPLLTCRLEEGKNPIRIICDTHLRTPLTSKIVKTANDIKTYIATSSEDKN
KMKLYQNHGCEILSIKKKGNHIDLSSLMQHLGNMQIDSLVLEGGSLMNWS
ALEQQIVDELKIYIAPKVFGGSAKFPVGGEGISLPNDAIRLKPYAFSQIG
NDYLIESEVIYPCSQE
>SP_0177 ribE, riboflavin synthase, alpha subunit
MFTGIIEEIGKVERIQKDSRNCKLSIKASKILTDIHLGDSIAVNGICLTV
THFNHQSFTVDVMNETWSRTALTLLKHGSEVNLERALSVNGRLGGHVVTG
HIDGTGKISSIKKDDNAVWYQINTQKEILDLIVEKGSITIDGISLTVAKV
SKVNFSVSVIPHTLEQTILKSKQVGSTVNLENDILGKYVQKLMDNSPKSE
ISKELLYQNGF
>SP_0730 spxB, pyruvate oxidase
MTQGKITASAAMLNVLKTWGVDTIYGIPSGTLSSLMDALAEDKDIRFLQV
RHEETGALAAVMQAKFGGSIGVAVGSGGPGATHLINGVYDAAMDNTPFLA
ILGSRPVNELNMDAFQELNQNPMYNGIAVYNKRVAYAEQLPKVIDEACRA
AVSKKGPAVVEIPVNFGFQEIDENSYYGSGSYERSFIAPALNEVEIDKAV
EILNNAERPVIYAGFGGVKAGEVITELSRKIKAPIITTGKNFEAFEWNYE
GLTGSAYRVGWKPANEVVFEADTVLFLGSNFPFAEVYEAFKNTEKFIQVD
IDPYKLGKRHALDASILGDAGQAAKAILDKVNPVESTPWWRANVKNNQNW
RDYMNKLEGKTEGELQLYQVYNAINKHADQDAIYSIDVGNTTQTSTRHLH
MTPKNMWRTSPLFATMGIALPGGIAAKKDNPDRQVWNIMGDGAFNMCYPD
VITNVQYDLPVINLVFSNAEYGFIKNKYEDTNKHLFGVDFTNADYAKIAE
AQGAVGFTVDRIEDIDAVVAEAVKLNKEGKTVVIDARITQHRPLPVEVLE
LDPKLHSEEAIKAFKEKYEAEELVPFRLFLEEEGLQSRAIK
>SP_0292 sulD, bifunctional folate synthesis protein
MDQLQIKDLEMFAYHGLFPSEKELGQKFVVSAILSYDMTKAATDLDLTAS
VHYGELCQQWTTWFQETSEDLIETVAYKLVERTFEFYPLVQEMKLELKKP
WAPVHLSLDTCSVTIHRRKQRAFIALGSNMGDKQANLKQAIDKLRARGIH
ILKESSVLATEPWGGVEQDSFANQVVEVETWLPAQDLLETLLAIESELGR
VREVHWGPRLIDLDLLFVEDQILYTDDLILPHPYIAERLFVLESLQEIAP
HFIHPILKQPIRNLYDALKK
>SP_0726 thiD, phosphomethylpyrimidine kinase
MTYLPVALTIAGTDPSGGAGIMADLKSFQARDVYGMAVVTSLVAQNTRGV
QLIEHVSPQMLKAQLESVFSDIPPQAVKTGMLATTEIMEIIQPYLKKLDC
PYVLDPVMVATSGDALIDSNARDYLKTNLLPLATIITPNLPEAEEIVGFS
IHDPEDMQRAGRLILKEFGPQSVVIKGGHLKGGAKDFLFTKNEQFVWESP
RIQTCHTHGTGCTFAAVITAELAKGKSLYQAVDKAKAFITKAIQDAPQLG
HGSGPVNHTTFKD
>SP_0718 thiE-1, thiamine-phosphate pyrophosphorylase
MFHKELLKLYFICGTTTCQGKNLYTVVEEALKGGITLFQFREKGEGALEG
LEKLELAIQIKELCKKYNVPFIVNDDIDLAMEIDADGVHVGQDDIGVDEI
RKLMPDKIIGLSIRNEEEFQQSKVEYVDYVGVGPVFGTQSKDDAGGTIGY
EGLELMRKLLPQMPLVAIGGIQTKHIKDIIKTNMDGVSIISAISYAKNIE
KTVREMSEQ
>SP_0725 thiE-2, thiamine-phosphate pyrophosphorylase
MNREALRLYLVTNRYQDSVESFLAKVETACRSGVTIVQLREKNLTTNQYY
QLAKQVKEITDAYQVPLIIDDRLDVCLAVDAAGLHIGDDELPVSVARKVL
GPEKILGVTAKTVKRALEAEKSGADYLGTGAIFPTTTKENAPITLISTLK
TICQTVAIPVVAIGGLTSENIDQLMGTGIAGVAVVRDLMQAEDIEAKTQA
FLKKLHNILS
>SP_0881 thiI, thiazole biosynthesis protein ThiI
MQYSEIMIRYGELSTKGKNRMRFINKLRNNISDVLSIYTQVKVTADRDRA
HAYLNGADYTAVAESLKQVFGIQNFSPVYKVEKSVEVLKSSVQEIMRDIY
KEGMTFKISSKRSDHNFELDSRELNQTLGGAVFEAIPNVQVQMKSPDINL
QVEIREEAAYLSYETIRGAGGLPVGTSGKGMLMLSGGIDSPVAGYLALKR
GVDIEAVHFASPPYTSPGALKKAQDLTRKLTKFGGNIQFIEVPFTEIQEE
IKAKAPEAYLMTLTRRFMMRITDRIREVRNGLVIINGESLGQVASQTLES
MKAINAVTNTPIIRPVVTMDKLEIIDIAQEIDTFDISIQPFEDCCTIFAP
DRPKTNPKIKNAEQYEARMDVEGLVERAVAGIMITEITPQAEKDEVDDLI
DNLL
>SP_0717 thiM, hydroxyethylthiazole kinase
MTSLKLLKEKAPLVICITNDVVKNFTANGLVALGASPAMSEFPADLEDLL
KYAGGLLINIGTLTDENWKLYQAALKIAEKYNVPAVLDPVACGAGEYRKK
VADDLINNYKLAAIRGNAGEIASLVGIDVASKGVDSAGVDNIDEIALAAN
EKFNIPIVVTGEVDAIAVNGEVVMIHNGSAMMPKVIGTGCLLGAVVASFI
GLEKGQELKSLKTAVLVYNIAGEIAEKRPNGHLPGTFKVEFINALYEITD
EDVKEFKRVK
>SP_1817 trpE, anthranilate synthase component I
MERIIHGDVLSPILAYMRLKGQHKVILESIPRDKETARFSILAYNPVFEI
KFENGVLYQNGQVIDRDPLDFLYEVIHKSQHHSELPFGGGAIGFVGYDMI
SLYEEIGQIPEDTIGTPDMHFFVYESYMVFDHKKEKIHVIEDALYSERSQ
EALEKSLNQVLEELRIPAPNEFEDLDLSPLDFKPHIAPHKFEGMVETARD
LIRNGDMFQCVLSQRFSAEVTGNPFDFYRNLRVTNPSNYLYFYDFGDYQI
IGASPESLVSVKNGIVTTNPIAGTRPRGATDEEDKALATDLLSDEKETAE
HRMLVDLGRNDIGRISETTSVQVTKYMEVELFRYVMHLTSVVKGRLLPEL
TAMDALKATLPAGTVSGAPKIRAMRRIYELETEKRGVYAGAIGYLSATGD
MDLAIAIRTMILKNQRAYVQAGAGIVYDSIAQNEYQETINKAKSMTRIGE
LRP
>SP_1816 trpG, anthranilate synthase component II
MILLIDNYDSFTYNLAQYIGNFAEVQVLRNDDSKLYEEAEKADGLVFSPG
PGWPVDAGKMEDMIRDFAGKKPILGICLGHQAIAEVFGGKLGLAPKVMHG
KQSNINFEAPSVLYQGIEDGRAVMRYHSILIEEMPEDFEVTARSTDDQAI
MGIQHKNLPIYGFQYHPESIGTPDGLSSIRNFIEEVVK