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# Vibrio vulnificus CMCP6, CMCP6

>VV10566 Carbamoylphosphate synthase small subunit
MSKSALLVLEDGTVFRGVSIGADGISVGEVVFNTSMTGYQEILTDPSYSQ
QIVTLTYPHIGNTGTTSEDEESSSIHAQGLVIRDLPLIASNFRSEQSLSD
YLKSQNIVGIADIDTRKLTRILREKGAQNGCIVAGNNLDEALALAKAKEF
PGLKGMDLAKEVTTKEAYQWKQGSWTLEGGLPEAKDDSELPYHVVAYDFG
AKRNILRMLVDRGCRLTVVPAETSAEDVLALNPDGVFLSNGPGDPAPCTY
AIEATKVFLENGLPVFGICLGHQILALASGAKTVKMKFGHHGANHPVKDL
DRNVVMITSQNHGFAADEATLPDNLRATHVSLFDGSLQGIHRTDKPAFSF
QGHPEASPGPHDAAPLFDHFIELIKQHSA
>VV11465 Aspartate carbamoyltransferase, catalytic chain
MTNSLYKKHIISIPELSRAELELIVKTAGQLKAEPNPELIKNKVVASCFF
EPSTRTRLSFETAIQRIGGDVIGFDDGGNTSLAKKGETLSDSVQVISNYV
DAFVMRHPQEGAARLASEFSNGVPVINAGDGANQHPTQTLLDLFTISETQ
GRLDNLNVAFVGDLKYGRTVHSLTQALAKFNNIRFFFVAPDALAMPDYIL
EDLDEAGISYSLHTDMETVIPELDILYMTRVQKERFDESEYAHIKSAYIL
TAALLEGARENLKVLHPLPRVDEITTDVDKTPHAYYFQQAGNGVYAREAL
LALVLNESL
>VV13041 Ribonucleotide reductase, alpha subunit
MNQQLTVTKRDGRKENIDLEKLHRVITWAAEGLDNVSVSQVELRAHIQFY
DGITTSDIHETIIKSAADLISEETPDYQYLAARLAVFHLRKKAYGQYEPP
TLYDHVARLVDMGKYDKHILEDYTKAELDELDAYLDHKRDLDFSYAAVKQ
LEGKYFVQNRVSGQIYESAQFLYILVAACLFAKYPKETRLDYVKRFYDAT
STFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATASSIVRYVSQ
RAGIGINAGRIRALGSEIRGGEAFHTGCIPFYKYFQTAVKCCSQGGVRGG
AATVFYPMWHGEARSLMVLKNNRGVEENRVRHMDYGVQLNKLMYQRLVEG
GNITLFSPSDVPGLYDAFFENQAEFERLYVKYENDPSIKKETVKALEMFT
LLMQERASTGRIYIQNVDHCNTHSPFDAEVAPVRQSNLCLEIALPTKPLA
NVEDDSGEIALCTLSAFNLGAINTLDDLKELSELVVRALDALLDYQDYPL
PAAYKSTMNRRTLGVGVINYAYYLAKHGVKYSDGSANGLTHRTFEAIQYY
LLKASVELAKEQGKCPLFHETNYAKGLMPIDTYKKDIDLICDEPLHYDWD
ALRAEIMEHGLRNSTLTALMPSETSSQISNATNGIEPPRGYVSVKASKDG
ILKQVVPDFIELKNNYELLWNIGSNDGYLHLVGIMQKFVDQAISANTNYD
PARYESGKVPMKKLLQDLLTAYKFGVKTLYYHNTRDGAKDEQKDAVQPQD
DDCAGGGCKI
>VV11054 Phosphoribosylaminoimidazole carboxylase, catalytic subunit
MKVGIIMGSKSDWPTMKLAAEMLDRFGVEYETKVVSAHRTPHLLAEYAST
AKERGLKVIIAGAGGAAHLPGMAAAFTSLPVLGVPVQSRALSGLDSLYSI
VQMPKGIAVGTLAIGEAGAANAGLLAAQILGTHDENIMAKVEAFRSEQTE
SVLANPNPAED
>VV12977 Orotidine-5'-phosphate decarboxylase
MIDQKVIVALDYDNQADALAFVDRIDPASCRLKVGKEMFTLFGPDFVREL
HKRGFSVFLDLKFHDIPNTCSKAVRAAAELGVWMVNVHASGGERMMTASR
EILEPYGKDRPLLIGVTVLTSMEQSDLAGIGLDVAPQEHVIRLATLTKNS
GLDGVVCSAQESSLLKNELGKEFKLVTPGIRPLGSEQGDQRRIMTPLEAV
QAGSDYLVIGRPITQAVDPAAVLQAINTSLTK
>VV10340 Phosphoribosylformylglycinamidine (FGAM) synthase, synthase domain
MRILRGSPALSEFRVNKLLELCREQDLPVTGIYAEFMHFADLTSELDAEA
LEKLEKLLTYGPTIEEHEPQGLLLLVTPRPGTISPWSSKATDIAQNCGLN
AVKRLERGTAYYVESSSELSSVQIDIVKSIIHDRMMEAVFGDLEAAAALF
SVAQPAPMTQVDILSGGRLALEEANVSLGLALAEDEIDYLVENFTKLGRN
PNDIELMMFAQANSEHCRHKIFNADWTIDGVEQPKSLFKMIKNTFETTPD
HVLSAYKDNAAVMTGSKVGRFFPDPETRQYNYHHEDAHILMKVETHNHPT
AISPWPGASTGSGGEIRDEGATGIGGKPKAGLVGFTTSNLRIPGFEQPWE
TDFGKPGRIVNALDIMLEGPLGGAAFNNEFGRPNLLGYFRTYEEKVTSHA
GEEVRGYHKPIMIAGGMGNIRDEHVQKKEIPVGASLIVLGGPAMNIGLGG
GAASSMASGQSAEDLDFASVQRENPEMERRCQEVIDRCWQLGDNNPIAFI
HDVGAGGISNALPELVNDGERGGKFQLRDVPNDEPGMSPLEIWCNESQER
YVLAVAPENMAAFDAICKRERAPYAVVGVATEERHLTLEDAHFDNTPIDM
PMDILLGKPPKMHREATTLKVDSPAMTRDGIELNEAVDRVLRLPTVAEKT
FLITIGDRTVTGLVARDQMVGPWQVPVANCAVTAASYDTYHGEAMSMGER
TPVALLDFGASARLAVGESLTNIAATDIGDIKRIKLSANWMSPAGHPGED
AGLYEAVKAVGEELCPALGLTIPVGKDSMSMKTKWNENGEEKEVTSPLSL
IITAFARVEDVRKTITPQLRTDKGETSLVLVDLGNGKNRLGATALAQVYK
QLGDKPADVDNAEQLKGFFDAMQALVRQDKLLAYHDKGDGGLLVTLAEMA
FAGHCGVNANIAALGDDVLAALFNEELGAVVQVKNDELDSVLSTLAANGL
EACSHVIGAIDASDNFVIRSGDAVILERSRTDLRVIWAETTHKMQALRDN
PACADQEFEAKKDNSDPGLNVSLSFDVNEDIAAPYIAKGAKPKMAILREQ
GVNSHVEMAAAFDRAGFEATDIHMSDILTGQAVLDEYHGLVACGGFSYGD
VLGAGEGWAKSVLFNAQAREQFQAFFNRENTFSLGVCNGCQMLSNLKELI
PGADLWPRFVRNESERFEARFSLVEVQKSDSVFFDGMAGSRMPIAVSHGE
GRVEVRDAQHLAAIEASGTVAVRFVDNLGNPTQQYPNNPNGSPNAITGLT
TKDGRVTIMMPHPERVFRTVANSWAPEGWGENGAWMRMFQNARKNLG
>VV10850 Guanylate kinase
MGKGTLYIVSAPSGAGKSSLISAMLEKNPTYAMKVSVSHTTRGMRPGEQD
GVHYHFVEKEHFEDLITKGEFLEYAEVFGNYYGTSRVWIENTLDKGIDVF
LDIDWQGARQIREQMPHAKSIFILPPSNGELERRLNTRGQDSEAVIAKRM
AEAKSEISHYNEYDYVIINDDFDTALMDFKAIIRAERLKQDKQAAKYSGM
LDALLAE
>VV21641 Nucleoside permease
MNILLSLLGVAALIGCAFLLSESRRSINWKTVFRALLLQVGFAALVLYFP
WGQAALAGLSNAVSGLLGFADEGIAFLFGDLASSGFIFAVRVLPIIIFFS
ALISALYYLGIMQKVIQVIGGGIQKFLGTSKAESLVATGNIFLSQGESPL
LIRPFLSSMTRSELFAVMAGGMASVAGSVLGGYAGLGVELKYLIAASFMA
APGSLLMAKIIVPERATPSDYTNIELDKSDQSNVIDALASGAMGGMKVAV
AVGTMLIAFVSVIAMVNTGLENLGELFGFTGVTLQAIFGYLFSPLAWLIG
IPSNEVLAAGSYIGQKIVMNEFVAFIDFVEHKSLLSEHSQVIITFALCGF
ANIGSIAIQLGSIGVMAPERRSDVANMGLKAVAAGTLANLMSACLAGIFI
SL
>VV11902 Xanthine/uracil permease
MKNALQGAQMLFVAFGALVLVPLLTGLDPNVALFGAGVGTLLFQLITKRS
VPIFLASSFAFIAPIMFGIQTWGIGATMGGLMAAGLVYVALGAMIKVRGV
GFIHKILPPVVVGPVIMVIGLGLAPTAVNMAVGKTGDGAVQLVNGDAAII
ISAVSLFTTIALSVFAKGFLKLVPIVGGILAGYSVSLFYGVVDFTPVAQA
AWLAMPNFTTPEFNINAILFMIPVAIAPAVEHVGDMLAISNVTGKNYLKK
PGLHRTIAGDGVATIAASMVGAPPNTTYSEVTGAVMLTKAYNPVIMTWAA
ITAIVLALVGKLGATLQTIPVPVMGGIMILLFGSIATVGLNTLIKNHVDL
HKSRNLVIVAVTLVFGIGGMAFGIGEFSLQGVSLCGIVAIILNLILPHDM
GENHVVDNAQMEEEVQN
>VV11053 Phosphoribosylaminoimidazole carboxylase, ATPase subunit
MHVLVLGAGQLARMMSLAGAPLNIQISAYDVTTGDVVHPLTLHLLGHGLE
QAIEYVDVITAEFEHIPHDVLAICQASGKFLPSSEAIKAGGDRRLEKALL
DHAGVRNANYYVIETREDFNKAIEHVGIPMVLKSALGGYDGKGQWRLKDA
AQIETLWQEMAACIAATPTQAIVAEEFVPFQREVSLIGARGKEGQIEVYP
LAENIHVNGVLSLSTAIDSPDLQEQAKHMFTAVAETLNYVGVLALEFFDV
DGQLLVNEIAPRVHNSGHWTQQGAETCQFENHLRAVCGLPLGSTKLVRET
SMINILGEDTLPASVMAMDGCHIHWYGKEKRAGRKMGHINVCGDYSGELQ
RRLCALANVLDEKAFPAVHEFAKKWQA
>VV13042 Ribonucleotide reductase, beta subunit
MAYSTFNQTKNDQLKEPMFLGQSVNVARYDQQKFEIFEKLIEKQLSFFWR
PEEVDVSSDRIDYNKLPDHEKHIFISNLKYQTLLDSIQGRSPNVALLPLV
SLPELETWIETWSFSETIHSRSYTHIIRNIVNDPSVVFDDIVENEHILKR
AKDIAHYYDDLIQLTNDYHRFGEGEHVVNGETIKVSLYELKKKLYLCLMS
VNALEAIRFYVSFACSFAFAERELMEGNAKIIKLIARDEALHLNGTQHMI
NLLRNGQDDFSFMQIAEEAKQQCFDLFKEAAEQEKEWAEYLFKDGSMIGL
NKDILCQYVEYITNIRMQAVGLPVAYPNATSNPIPWINAWLSSDNVQVAP
QEAEISSYLVGQIDNEVHSDDFEGFEL
>VV21364 Purine nucleoside phosphorylase
MTFDPVNQALETIYSYKPNYQPKVAFILGSGLGVIADELDDKIVIPYQEL
EGFPVSTVEGHSGELVLGKLFGIDVICMKGRGHYYEHQTMKVMTNPVRTF
KRLGCEFLLVTNAAGSLRPERIDVGSLVVFNDHINTMPESPMTGPNDDAY
GPRFFSLANAYDKSLRSEALTVAEAEGIHLNQGVFVSYTGPNFETAAEIR
MMQIIGGDVVGMSVVPEVISAAHCGLPVLALCAITNMAEGLSDVTLSHAQ
TLACAKLAEADFIKLIKAFIKSHFATS
>VV13025 Uridine kinase
MSEKSQCVIVGIAGASASGKSLIASTIYNELRAKVGDHQIGVITEDCYYN
DQSHLSMEERVKTNYDHPNALDHDLLCEHLEKLMKGESVEVPEYSYTEHT
RTENTTTMTPKKVIILEGILLLTDPRLRDLMHATVFMDTPLDICLLRRVK
RDVEERGRTMESVLKQYQKTVRPMFMQFIEPSKQYADIIVPRGGKNRIAI
DVLKAHIAKLLKA
>VV12797 Phosphoribosylaminoimidazolesuccinocarboxamidesynthase
MSLADQVLAVNDDLPIRTDKPVHSGKVRSVYWLTEEDSARLIKEKGYNVA
PDAPLAIMVISDRISAFDCIWHGEHGLNGVPGKGAALNAISNHWFGLFKE
NGLADSHILDIPHPFVWIVQKAKPVKIEAICRKYITGSMWRAYEKGEREF
CGIQLPEGLEKDKALPDLLMTPSTKGILKGIPGVPEADDVNITRQNIADN
FAAFNFSSADDIALYEKLLKDGFGVISEALANVGQIFVDTKFEFGYVTDA
AGNEKLIYMDEVGTPDSSRIWDAQEYQAGKIVENSKEGFRQFLLNYFPDP
DILLNKDRMPEREALARDNELPEEALMAVSRTYINIAEKITGSAIVLSDN
PKQEIIDILGREYGLID
>VV10565 Carbamoylphosphate synthase large subunit
MPKRTDIQSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVILVNSN
PATIMTDPDMADATYIEPIQWEVVRKIIEKERPDAVLPTMGGQTALNCAL
ALEKHGVLAEFGVEMIGATADAIDKAEDRSRFDKAMKSIGLECPRADTAK
TMEEAYKVLDMVGFPCIIRPSFTMGGTGGGIAYNKEEFEEICRRGLDLSP
TNELLIDESLIGWKEYEMEVVRDKADNCIIVCSIENFDPMGIHTGDSITV
APAQTLTDKEYQLMRNASLAVLREIGVETGGSNVQFGINPKDGRMVIIEM
NPRVSRSSALASKATGFPIAKIAAKLAVGFTLDELQNDITGGATPASFEP
TIDYVVTKIPRFNFEKFAGANDRLTTQMKSVGEVMAIGRNQQESLHKALR
GLEVGATGFDEMVDLDSPDALTKIRHELKEAGAERIWYIADAFRAGMSVD
GVFNLTNIDRWFLVQIEEIVKLEEQVKAGGFAGLTQDVLRQMKRKGFSDA
RLSKLLGVAESEIRRLRDQFDIHPVYKRVDTCAAEFSSDTAYMYSSYDDE
CEANPTDKEKIMVLGGGPNRIGQGIEFDYCCVHASLALREDGYETIMVNC
NPETVSTDYDTSDRLYFEPVTLEDVLAIARVEKPKGVIVQYGGQTPLKLA
RALEAAGVPIIGTSPDAIDRAEDRERFQQAVDRLGLLQPENATVTTMEQA
VEKSREIGFPLVVRPSYVLGGRAMEIVYDEQDLRRYFNEAVSVSNESPVL
LDRFLDDAIEVDIDAICDGERVVIGGIMEHIEQAGVHSGDSACSLPAYTL
SQEIQDKMREQVEKLAFELGVRGLMNTQFAVKDNEVYLIEVNPRAARTVP
FVSKATGAPLAKIAARVMAGQSLESQGFTKEIIPPYYSVKEVVLPFNKFP
GVDPLLGPEMRSTGEVMGVGATFAEAYAKAELGCGNVYPEGGRALLSVRE
GDKQRVVDLASKLLKLGYKLDATHGTAVILGEAGINPRLVNKVHEGRPHI
LDRIKNNEYTYIVNTAAGRQAIEDSKVLRRGALAEKVNYTTTLNAAFATC
MSHTADAKASVTSVQELHAQVQASLKA
>VV12379 Cytidine deaminase
MQLQGFTMKSRFENALASAPESLSRHLAPIILAADFDASLSTVQFDELLK
QTGMTDNQLRVALLPFAAAYSYAPISEFYVGAIVRGLSGALYFGANMEFD
GVQLGQTVHAEQSAISHAWMKGEQGLSDITINFSPCGHCRQFMNELSSAK
ELKIQLPEREEKKLHDYLPDSFGPSDLGIESALMSQVHHGFATEDDDALM
QRAVEAMNRSHAPYTHNLSGVALQTESGRVYLGAYAENAAFNPSLPPLQV
ALIQLLLAGERFENIQSAALVESHKGKISHLACTQSTLEALNPDIPVSYL
SL
>VV20788 Purine-cytosine permease
MAADNNFSLGPVPNSARKGVASLTMVMLGLTFFSASMWTGGSLGTGLSFN
DFFLAVLIGNLILGIYTSFLGYIGASTGLSTHLLARFSFGSKGSWLPSAL
LGGTQVGWFGVGVAMFAIPVNKATGIDTNTLIVISGLLMTATVYFGISAL
MVLSAIAVPAIALLGGYSVVEAVNSVGGVAELQKVQPAQPLDFSVALAMV
VGSFISAGTLTADFVRFGRKPKGAVMVTMVAFFIGNSLMFIFGAAGAAVT
GQSDISEVMIAQGLLIPAIIVLGLNIWTTNDNALYASGLGFSNITGLPSK
YISMVNGLVGTLCALWLYNNFVGWLTFLSLAIPPIGGVIIADFFINRKRY
SNFAAAEFQTVNWAGIIAVAIGVVAGHFLPGVVPVNAVLGGTISYLILNP
ILNKKRLAELPA
>VV10856 Xanthine/uracil permease protein
MTTPNPTRKTDLIYQLNDRPPLPQTLFAALQHLLAMFVAVITPSLIICQA
LGVSAEQTNTIISMSLFASGISSFIQIRTFGPIGSGLLSVQGTSFNFLGP
IIGAGLALKAGGASVESMMAAIFGTILVASFAEILLSRVLEYARRIITPL
VSGIVVTLIGLTLIQVGLVSMGGGYAALGDGTFGSLDKLALAGTVLGLIV
LLNRAKNPYVRVASIVIAMLVGYVMAYFMGMVDTRQASSSALIALPIPMQ
FGLSFDWSLFIPLVLIFLITALEAIGDITATSEVSGEPVKGPVYMKRIKG
GVLADGLNSALAAVFNSFPNSTFSQNNGVILLTGVASRYVGYFIAGMLVL
LGLFPGVAGFVQLIPEPVLGGATIVMFGTIAAAGVRIISRVDLDRRAILI
MALSFSMGLGIAQKPEILQFMPEFIKSIFSSGVAAGGITAIVLNLLLPEK
LQGEEEEKAHEPATVKR
>VV10516 Thymidylate synthase
MKQYLELCRRIVDEGHWVENERTGKRCLTVINADLTYDVANNQFPLVTTR
KSFWKAAVAELLGYIRGYDNAEDFRKLGTKTWDANANLNDAWLNNPYRKG
EDDMGRVYGVQGRAWAKPDGGHIDQLRKIVDDLTRGVDDRGEILNFYNPG
EFHMGCLRPCMYSHHFSLLGDTLYLNSTQRSCDVPLGLNFNMVQVYVFLA
IMAQITGKKPGQAFHKIVNAHIYEDQLALMRDVQLKREPLQAPTFHINPE
IKSLEDLETWVTLDDFWVEGYEHHDPIQYPFSV
>VV11901 Uracil phosphoribosyltransferase
MDMKVVEVKHPLVKHKIGLMREGDISTKRFRELATEVGSLLTYEATSDFE
TEKVTIEGWNGPVEVDQIKGKKVTVVPILRAGLGMMDGVLEHMPSARISV
VGIYRDEETLEPIPYFNKLASNMEERIALVVDPMLATGGSMIATIDLLKE
KGCQQIKVWVVVSAPKSN
>VV10430 Nucleoside diphosphate kinase
MALERTFSIIKPDAVERNLIGEIYHRIEKAGLRIIAAKMVHLNDEQASGF
YAEHEGKEFFPALKEFMTSGPIMVQVLEGENAIARYRELMGKTNPEEAAC
GTIRADYALSMRHNSVHGSDSPASAAREIAFFFPESEICPR
>VV12472 Adenylate kinase
MKRINVIGTSGSGKSTFSRQLASKLKYPYLEMDAIFWKPNWQESTDEEFY
ANLTESLSGEHWVLDGNYSRTAEIKWARADTIIWVDYSFSRTLFQAVKRA
LTRIVTKQELWGKTGNVESFKKSFLSKDSIILWTLKTYKTNRIRYTELLN
DPRYSHIKFVRVTSPKKARVFIDELRT
>VV20768 Adenylosuccinate synthase
MTSIVVVGANWGDEGKGRIVDFLAENAAASVRFQGGNNAGHTVVNHFGTF
KLHQLPSGVFNPGCLAVLGPGMVISPALLTQELAEVEQSGVKVNLCISDR
ATLCLPLHALEDTLEEQRLGDKAYGSTRQGIAPAYGDRVMKKGILLGWLK
QPEVLVERLQFMLDWKLPQLRALYPEFKFEQTAQEMADWLLEVSAPWRDA
ICNVSVPLKALQAEKQNLLFEAQLGAGRDLVYGEYPWTTSSNVVSAYAGI
GSGLPALRPERVIAVAKAFSSSVGTGTLITAMEEQDAFREAANEFGATTG
RPRDMGYFDAVATQNGVELQAATEIALTKLDCLTGLDDLKICVAYQGDHS
ENPIWPQTAALAPVYEKMPSWSEDITACRRFEDLPQAAQQYVLRIEELMG
VPVSMVSVGPGREQMILR
>VV21131 Dihydroorotase
MFTLLKNADLYAPNHVGNVDILVGQGKILAIEPQLNLHGLEAVTQIDCHH
KMVTPGLIDQHLHLTGGGGEAGFASRTPQVTLSHLIQAGSTTVVGVLGTD
GISRSPRDLYAKAAALTEEGITAFMHTGSYEVPTQTITSSIRDDITFLPS
VLGVKIAIADHRCSFPSLHELARIASDIRIAALLAKKRGLLHMHMGALKD
AFAPIFELIQMGIPIYHFSPTHVARTAPLFEQAIEFAKMGGYIDVTSGGT
LYTSPQEAILHALEQGVAPSHITISSDGNGSLPKFDAQGNIIGLTAASVD
GNLKLLPMLIDCGISPEVAFSMLSANVADSLGIRKGRIQVGMDADLCIFN
QDFSLNSVLAKGQTMLLNHELLVTGNFE
>VV11299 Adenylosuccinate synthase
MANNVVVLGTQWGDEGKGKIVDLLTEDAKYVVRYQGGHNAGHTLVIDGVK
TVLHLIPSGILRDNVKCVIGNGVVLSPEALIKEMKPLEERGIPVRERLFI
SEACPLILPYHVAMDQAREIARGKKAIGTTGRGIGPAYEDKVARRGLRVG
DLFDMEAFAEKLKEVMEFHNFQLVNFYKAEAVSYEEVLEQARGYAELLTS
MVIDVTDELDAARKRGDKIMFEGAQGTLLDIDHGTYPYVTSSNTTAGGVA
AGSGFGPRYLGYILGIAKAYCTRVGAGPFPTELYDGQEKQDPVGKHLGTV
GHEFGATTGRLRRTGWFDAVAMRRAIQINSVSGFCLTKLDVLDGLKELKI
CTGYQMEDGSVLEVSPMAAEAFEKVTPIYETMPGWSENTFGAKSLEDLPQ
AAINYIKRIEELTGVPVDIISTGPDRNETIVKVHPFES
>VV13002 Thymidylate kinase
MKQAKFIVIEGLEGAGKSTAIQTVLDTLRQAGINEIAQTREPGGTPLAEK
MRALVKEEHPGEHLHDMTELLLLYAARVQLVENVIKPALHEGKWVVGDRH
DLSSQAYQGGGRQIDATLMKNLRDTALGEFKPAFTLYMDIDPKVGLERAR
GRGELDRIEKMDISFFERTRQRYLELAKSDASIVTINAEQSIEQVANDIR
SALNLWLEQLQD
>VV20237 5'-nucleotidase/2',3'-cyclic phosphodiesterase
MKKEKVTMIKTNKPVTLKLAHINDTHSYFEPTSLQLKIQLQEAQIEPYVS
AGGFARIATRAQQIKQEAERQNKGFLFVHAGDCFQGTLYFSLFKGKANAD
LLNSMGIDAMALGNHELDMGNEPVAQFVRRIDFPLLAGNWNLSAESDEKT
LKISDADNIRSFDTETRTATYIIKEINGEPVALFGLSLDKMADIANPDPD
TPFENAVETATATVRLLQSLGINKIILLSHLGYEGDIELASKVSGIALIV
GGHSHRLQGDFSAIGLGKDDDYGLKINDTYVVQAGFHALTMGHCEIEFAA
DGSVKRFVGRNELLIGRRMFLDPGLNQQSDEDWYNQAADFIDGQCNVVVC
KKDPDIQHLMQNKYIPRVRELQKTIIAHTDRALRHVRIPDEVGPSELAPM
VAASFVHALNKRQRQVQFAIHNAGGVRNSLNSGDVSVADVAGKLLPFAVP
IGCYDVQGKTIAAALEGAINNATNNGVEGTGSGSYPYTYGLSYRYCPQNP
AGHRIEALQICLDGRWQPVSPLQWYRGCSSAYTMKGKEGYEAIRQMKGEG
WVSNLSMADCFIEYLSDLPNVLNQQDRARHV
>VV20216 Formyltetrahydrofolate synthetase
MTKGKTINGFEREEGFDISAASELMAILALSKNLQDMRERIGKVVLAYNL
DSEPVSAEQLQVAGAMTVTLKEAIKPTLMQTLEGVPTLIHAGPFANIAHG
NSSIIADEIALKLSSYVVTEAGFGSDMGLEKACNIKSSTSHKAPDCVVIV
ATLRGLKANSGLYDLKPGMPLPDALFQPDRAALESGFSNLKWHIDNAQKY
GLPVVVAINQFPQDSAEELGQLKLWIQQLPLNVRVAISEGFAKGGKGMEA
VAREVIEACDAPANFRPLYRAEQTLEEKIITVCTKGYGCGEVQFSDTAKQ
QLALYQTLGFGELAVCMAKTPLSISSDSSLKGAPSGFTIMVREVRLCAGA
GFVYALTGNVMTMPGLPDIPAFMALDIDENGDIVGLS
>VV10128 Nucleoside permease
MNSLLGVVAILLFAWLLSTNRKNIRLKTVGLAFALQVAFALLVLYVPAGK
NALNGVTGAVSNLINYGQEGIAFLFGGLATGGFTFAINVLGIIIFFSALI
SGLYHIGLMPKVINLIGGALQKLLGTGRAESLSATANIFVGMIEAPLVVK
PYLKHMSDSQFFAVMTCGLASVAGGTLVGYASLGVELNYLIAAAFMSAPA
GLLMAKILMPETEAQAEDVQMENVEMPKATNVVEAMADGAMSGLRIAVAV
GATLLAFVSVIALLNGLLGWVGSWFGISLSFELILGYLFAPVAWLLGIPW
HEAITAGSLIGNKIVVNEFVAFIQLMQVKQDLSAHSQAIVTFALCGFANI
STMAMLIGGLGSLVPEKRSFISKYGFRAITAGVLANLMSASIAGVILSL
>VV11578 CTP synthase
MTTNYIFVTGGVVSSLGKGIAAASLAAILEARGLKVTMMKLDPYINVDPG
TMSPTQHGEVFVTEDGAETDLDLGHYERFIRTKMTKRNNFTAGRVYSDVL
AKERRGDYLGATIQVIPHITNDIKDRVINGSQGHDVAIVEVGGTVGDIES
LPFMEAIRQLAVEIGRERAMFMHLTLVPYLAAAGEVKTKPTQHSVKELLS
IGIQPDILVCRSDRMIPANERKKIALFCNVPEKAVISMKDVDSIYKIPQL
IKSQGLDDLVCARFGINAPEADLSEWEQVIYEEANPTGEVTIGMVGKYIE
LPDAYKSVNEALKHAGLKNRLSVNIKYVDSQDVETKGVEVLQGLDAILVP
GGFGDRGIEGKILAAKYARENKVPYLGICLGMQVALIEYARNVAGMEGAH
STEFNKDTKYPVVGLITEWVDSEGNVEERTESSNLGGTMRLGSQLCHLAK
GTKARELYGSDTIHERHRHRYEVNNNLRPQIEKAGLKVSGLSADKKLVEM
IENPNHPWFVAAQFHPEFTSTPRDGHPLFSGFIKAAGENARGELK
>VV11464 Aspartate carbamoyltransferase, regulatory subunit
MNKETKLQVEAIKNGTVIDHIPAQVGIKVLKLFDMHNSSQRVTIGLNLPS
SALGNKDLLKIENVFINEEQASKLALYAPHATVNQIEDYQVVKKLALELP
EFVSDVFECPNTNCITHNEPVASNFRVFEKKGDVRLKCKYCEKVFSREIV
TER
>VV12064 Uridine phosphorylase
MSQAVFHLGVTEADLNGATLAIIPGDPARVQKIAEEMENPVFLASHREYT
LYRAELDGKPVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPH
VNVGDMIVTTGSVRLDGASLHFAPMEFPAVADFDVATAMKAAAQESGATV
HTGVTASSDTFYPGQERYDTFTGRVVSRFQGSMKEWQDMGVLNFEMESAT
LLTMCASSGLRAGCVAGVIINRTQKEIPDHATLKETEARSIKVVVESARK
ML
>VV12378 Phosphoribosylglycinamide formyltransferase 2
MFGTATRESATRVLLLGSGELGKEVAIECQRLGLEVIACDRYPDAPAMQV
AHRSYVFDMLDASELEKVIAAEQPAFVVPEIEAIATDKLVELEEQGLNVV
PSAKATKLTMNREGIRRLAAEELGLTTSPYRFADNYQQFVEAVEAVSIPC
VVKPVMSSSGKGQSVIKSPADIEKAWQYAQEGGRTGAGRVIVEGFIDFDY
EITLLTVRAVDGVHFCAPIGHRQEDGDYRESWQPQQMSENAIKAAEYTAE
QVVNALGGYGIFGVELFVKGDKVIFNEVSPRPHDTGLVTLISQEMSEFAL
HVRAFTGMPVNKIVQYGPSASAVILGNGQSENLRFDGMSDALEQPQTQLR
LFGKPDINGRRRLGVVLTRRSSTEKAVDAAIESAKKIKIIY
>VV12907 Thymidine kinase
MYFYYSAMNAGKSTTLLQSSFNYQERGMTPVIFTAALDDRYGIGKVSSRI
GLQAEAQLFKADTNLYQEIAALNEVEKRHCILVDECQFLSKEQVYQLTEV
VDKLHIPVLCYGLRTDFLGELFEGSKYLLSWADKLVELKTICHCGRKANM
VIRTDEHGKAIKEGDQVAIGGNDRYVSVCRQHYKEALGK
>VV10465 Exopolyphosphatase
MVVAKVVDEDLQLISRHKQRVHLADGLDMEMNLSHSAMERGLECLAMFAE
RLQGFEPENVRIAATHTLRQARNAHLFLQRAKQVLPFPIEIIPGEEEARL
IYLGVAHTQLEVSSKLVVDIGGGSTEMIIGKDFEPELLNSKQMGCVSFTS
RYFANGKMTKKNFNKAMVACEQKLESIASQYRKKGWEIAYGSSGSIKAIR
EVLVGIGFEDGLITQARLNTLMDMLCSFETIDDIQLPGLTDERKPVFAAG
VAILSAIIQTLKISEMHYSDGALREGLLYEMEARFARSDLRMRTTENLAK
KHLVDLEHAARVKGLAIELLEQAHKPLGIKRESELATLLEWAALLHEVGL
SISLRGFHRHSAYILQHTNMPGFNSEQQLLLAFLTRYQRKSLKLTELPDF
HLYSREQVINLIRILRLAILINGQRNDDPLPEFHLQVKENHWTLQGKETD
WQENNKLLSADLQSEQERWQQVNWQLELD
>VV10728 2`,3`-cyclic-nucleotide 2`-phosphodiesterase
MKVAVKPLSLAVLSSMLVMAGPAMAETIKLRIIETTDIHTNVMDYDYYKD
KPSQQIGLTRAATLVKQARGEVVNSVLVDNGDLIQGSPMGDYMAAKGIKA
GEVHPVYKAMNQLSYDVGNIGNHEFNYGLEFLAETINDADFPYVSANVFD
KKTGKHYFKPYIIKDHTFKDVNGEEHTIKVGYIGFVPPQIMVWDKKNLEG
KVFAKDIKETAEELVPQMKKEGADVIVAIPHSGVSSDPYKIGAENSVYYL
SEVDGIDAIAFGHSHAVFPGKGFDNIQGVDNQAGTINGVAAVMPGRWGSH
VGIIDLELQQKQGKWTVVKGQTEARPIFDKTTKKPLVDADAAMVKALEAD
HKGTREFVNQPIGKANDVMYSFLALVQDDPTVQIVNLAQKDYVERFIQGD
PDLAGLPVLSAAAPFKAGGRKNDPANFTEVESGQLTFRNAADLYLYPNTL
VAMKVTGHEVKEWLECSAGQFKQIDVSSTAPQSLIDWDGFRTYNFDVIDG
VNYQIDVTKPAKYDGDCKVINADSERVIGLTYQGKPIDVKQTFIIATNNY
RAYSNKFPGTGSEFVAFDSPDENRTVVANYISRVSQEKGEVTPSADNNWT
FAPIKSDKALDIRFETSPSDKAAQFIKEKGIYPMKQIATDDVGFAVYQLD
LQK
>VV10146 Diadenosine tetraphosphate hydrolase
MSFELHPQLAKDTTVIGHFPLCVALLHKDNAVPWVILVPKRANLKELHHL
PMQEQQQFLLESQAVSQALEATFRPDKLNLGALGNMVPQLHIHHIARFKD
DVAWPGPVWGNTNGEFRTEEEQNELLVRIKNVLSLSSIFQKA
>VV10014 dGTP triphosphohydrolase
MESTLSLTIRSQWLERHDDEHKIRRDDHRSPFQRDRARILHSAAFRRLQA
KTQVHGNSLEDFHRTRLTHSLEAAQLGTGIVAQIKKKQPEYRDLLPTDSL
IDALCLAHDIGHPPYGHGGEVALNYMMRDHGGFEGNAQTFRIVTQLEPYT
EHFGMNLSRRTLLGLIKYPAFISQTRAASQPAPVSHQRQIKAKQWSPAKG
IYDCDKALFDWVLAPLSETDKQQLNAMRDCPHDALSHRKTRYKSLDCSIM
ELADDIAYGVHDLEDAIVLGLVTRSQWQEGAASQLADCGDPWFEKHISSI
GEMLFSGQHHQRKDAIGGMVNALLTSIDVKPVDGEFESPLLAFNAYLDIG
MEKALSILKHFVSQYVIQIPQVQIVEYKGQQIIMDLFEALSADPQRLLPL
PTRHRWELAETDTSKMRVIADYISSMTDGHAQRLHQQLFSSHH
>VV12067 HIT family hydrolase
MHTTLAHTYPVKQRRYGVHMAEETIFSKIIRKEIPAQILFQDDLVTAFRD
INPRAPKHILIIPNKLIPTVNDVEADDEAMMGRMFTVAKQLAKEEGIAEE
GYRLIVNCNAHGGQEVYHIHMHLVGGKPLGPMLLG
>VV12373 ADP-ribose pyrophosphatase
MIVTIDMICLKLGEKGLEVLLIKRTNPERPQHGMWSIPGGFVFEHDLSQE
GGQPADADFDSARRRICRQKIHTYPHYISEPMVDGNPKRDPHGWSVTIAH
YALLNQTNIEQIQNCGLCDQQLAWFALESVLQGEVALAFDHADLIRLAWT
KLRAAIEYTSVVLFALEKEFLVSDIIHAYAKFGVDVNRMTIKRRLIDTGV
IVSANKIASTNKGKGGKPAQVYSLADKHVTYFQTCLR
>VV11303 Cytosine deaminase
MQTKEQTFAIHHESLTIAANYTDACSKENRMLKRNVIAAAIAGMSLFSSM
SYAAQPADLMITDAMILTMNKDKVVYQNGTVVVKENKIIAVGDADVAKQY
QAKQVLDVDGDIVMPGLINTHTHVSMTVFRSLGDDVPDRLHRYIFPLEAK
LVSRDMVRIGANLGNVEMLKGGVTTYADMYYFEDEVAKTVDQIGMRAVLG
QSVIQFPVADAKNADEGIQYALNFIDQYQDHPRITPAFAPHAPYTNTTET
LQKIAKLSLEKNVPVLIHLAESTREQEKIAERSNGLSPVQYMHQIGALNA
NLVGAHMILVDDKDIELVKQADMGVAHNMSANIKSAKGVAPALKMYDENV
RIGLGTDGPMSGNTLSTIDEFNQVAKVHKLVNHDRAAMPPLKVIDMATMG
AAKALHMEDKIGSLEVGKLADIIVIDTKAPNMVPVYNPYSALVYSANSGN
VRHAIVDGKLIMQERQINTVNEEQIRQEALAFTDIVRKTVLDSGEEIR
>VV20789 Cytosine deaminase
MTTLLIKNATLKGQEGLQQILIEDGQFTRIENNNVELNYTGDVLDAEGGM
AVAPFCEPHIHLDTTQTAGEPSWNISGTLFEGIERWAERKETLSIEDVKS
RAKQTLKWQIANGVQHVRTHVDVSDPTLIALKAMVEVREEMKEWVDIQIV
AFPQEGILSYPNGKELLEEAVQLGADVIGAIPHFEFTREYGIESLHYVFE
LAQKYDRLIDVHCDEIDDEQSRFVETLAALAHKFNMGHKVTASHTTAMGS
YNGAYASRLFRLLRMSGINFVANPLVNIHLQGRFDDYPKRRGVTRVKEML
NANINVCFGHDDVFDPWYPLGTANMLQVLHMGLHVCQVMGYDQINTSLDL
ISTNSARTLNIQDKHGIEAGKPGSLLILPAENGFDAVRRQVPVRYSVRHG
KVIAETQPATTHIHLGEREQVTFQR
>VV11227 AICAR transformylase/IMP cyclohydrolase PurH
MNNARPIRRALISVSDKTGIVEFAQALAERGVDILSTGGTARLLAEQGIA
VTEVSDYTGFPEMMDGRVKTLHPKVHGGVLGRRGQDDEVMAKHGINPIDM
VVVNLYPFAETVAKEGCTLADAVENIDIGGPTMVRSAAKNHKDVTIVVNA
SDYHRVITEMDANDTSLTLETRFDLAIAAFEHTAAYDGMIANYFGTMVPS
YGENKEGDEESKFPRTFNQQFIKKQDMRYGENSHQAAAFYVEANPQEASV
ATARQIQGKALSYNNIADTDAALECVKEFNEPACVIVKHANPCGVALGKD
ILEAYNRAYQTDPTSAFGGIIAFNQELDAETATAIVERQFVEVIIAPSVS
AEAMEVVAAKKNVRLLECGEWTTKTTGFDVKRVNGGLLVQDRDQGMVSLD
DLKVVSKRQPTEEELKDALFCWKVAKYVKSNAIVYSKGDMTIGVGAGQMS
RVYSAKIAGIKAADEGLQVEGCVMASDAFFPFRDGIDAAAEAGIKCVIQP
GGSMRDDEVIAAADEHGMAMIFTGMRHFRH
>VV11842 Carbamoylphosphate synthase large subunit
MRILITGARAPVALEWAAMCIKHGHDVILTDSLAQPLGAFLRGIEHYVKT
ASPRFSFPTYQQQILNLLTQQRIDMVIPTCEEVFYLAHIAQQCPRVHFFL
PNSTLLRSLHNKFTVFDQLRNLPEISLPKTRLVTDKHDIKINADSVLKPV
YSRFGGEVIRDITRQSISTLTMSTQHPWVQQEKIHGAPICNYAIFEHGQM
RAHQAYLPKNCVNGSAASAFQPIVDDRLEAFMTAFGHRHHYHGQVSFDFI
QTNDELYIIECNPRATSGLHLLSPQCTHLFPELAFSFPTKPQLHHLGAVS
LIARGGLSFFKANTWQDWLSGVNVMRQHDLPIRYQMLSVFELLQIARKNK
VKFAAASTVDIEWNGEEIP
>VV10940 Guanosine-5'-triphosphate,3'-diphosphatepyrophos phatase
MSQAGNSPLYAAIDLGSNSFHMLVVRHIDGSVQTMAKIKRKVRLAAGLDE
HNALSKEAMQRGWDCLSLFAERLQDIPAEHIRIVGTATLRTATNVDLFLQ
KANQILGHPIEVISGEEEAATIYKGVAHTSGGSGRRLVVDIGGASTELII
GEGFEAKALTSLKMGCVTWLENFFKDRQLSARNFEAAIEGAKQTLLPILE
QYKSLGWDVCVGASGTVQALQEIMLAQGMDEVITHAKLKRLQKQAMLADH
LEELEIEGLTLERALVFPSGLSILIAIFELLEIDAMTLAGGALREGLAYE
MMSELRQDDIRARTIGSIQSRYQLDSQYGQQVANLALKLLQQVGDVMWIP
EPQGAMLLETTAKLHEIGLTIDFKKGGEHSAYLMQHLDLPGFTRAQKFLM
GEIARRYREGLTSLPEQHALSGNSGKRLLRLLRLAVILSHRRQPSLEPEV
TLSAEGDKLTLAIDAQWLENNPLTAAELELEANRQTDIGWPLVIESR
>VV20909 Thymidylate kinase
MLGEDIVKNIFDTLKINKKILLPEVIIFVKADIETINNRIEARGGTVQWY
GDAVTQNNSVESAYHKVFKWFDIPIVEVDTSEKYGRSVEENYLLMKEQVE
HVLSGGSNFYSF
>VV11401 Thymidylate kinase
MTITELRNLYREKQLVEAIIEPSIQEGAWVVEFRHARGGFVLLTDSHGEE
CQYQDLDEASKSAMAVGFQQVRVETR
>VV12956 Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA
MISLEAYQDLLDPINHFLQCETPSEWVEEAKKPENLPTILIDHLLCELKA
GQSAMYLIRKYAVDKESSHTLLDWFKPYENFAYRGIGSIETLKGKSNISK
AIMAKSDSPYSQELIDKMVLLIKEELHHFYQVLEIICARGIEYENVTASR
YAKGLLSHMKTHEPETLIDKLIIGGYIEARSCERFAKLAPHMDDDIAKFY
VSLLRSEARHYQDYLTLAEQIAGKDISERVAYFGQIEAQLICSKDDDFKF
HSGVPTR
>VV11636 Hypoxanthine phosphoribosyltransferase
MESSRDVRILKDLDDDIKGKDVLIVEDIIDTGNTLNKIKEILSLREPKSI
EICTLLDKPSRREVPVPVKWIGFEIPDEFVVGVGIDYAQKYRHLPFIGKV
VPQE
>VV11520 Xanthosine triphosphate pyrophosphatase
MLKNNENTMKKIVLATGNQGKVREMADLLADFGFDVVAQSEFNVSEVAET
GTTFIENAIIKARHAAKETGLAAIADDSGLEVDFLQGAPGIYSARYAGEK
ASDQENLEKLLTAMEGVPEAQRTARFHCVLVLMRHENDPTPIVCHGKWEG
RILTQAHGDNGFGYDPIFFVPEDNCASAELEPVRKKQLSHRGKALKQLFA
TLREQPLV
>VV11899 Folate-dependent phosphoribosylglycinamide formyltransferase PurN
MKKIVVLISGSGSNLQAILEACECDTSRAKVCAVFSNKADAYGLERAKQF
SVPAHYIDPKAFTDRESFDRELMKAIDEYQPDIVVLAGYMRILSGEFVRH
YLGKMVNIHPSLLPKYPGLHTHQRAIDAGDSEHGTSVHFVTEELDGGPVI
LQAKVPVFAEDDAQSLAERVLTQEHSIYPLVVKWMAEERLVMQQGVAYLD
GQPLGSAGYAAE
>VV21373 Uridine phosphorylase
MSKQPHLCVDETQVAERVIVCGEPDRANRIAALLENAELVAENREYRLFN
GEFQGKAITVCSTGIGAPSMIIAVEELKQCGAKYIIRVGSAGAMQPNIAL
GELIVAEGAVRDEGGSKAYIDAAYPAYASFSLLKGLDGYLQTQAVPYHMG
VVRSHDSFYTDDEETLCQYWNKKGILGADMETSALFTVGRLRGLHVASVL
NNVVRYQQDVKEGVSQYVNDDDAMMAGEKRASLAALTALSCQ
>VV10143 Formyltetrahydrofolate hydrolase
MEKKTLLTHCSDAPGLISKITNICYKHQLNIIHNNEFVDNSSGHFFMRTE
LEGYFNDHTFLADLDQALPQGAKRKLVSSERKRIVILVTKEAHCLGDILM
KNYDGSLDVDIAAVVGNYDKLQSLTEKFDIPYHHVCHEGLDRESHEQKML
EVIGQYQPDYLVLAKYMRVLTPGFVEKYHHKIINIHHSFLPAFIGAKPYQ
QAFDRGVKIIGATAHFVTNDLDEGPIIKQDVIPVDHNFSAQDMAQAGRDV
EKNVLSKALNKVLNDHVFVYGNKTVIL
>VV11726 Thymidine phosphorylase
MYLPQEIIRKKRDGEALTADEINFFIQGVANNTVSEGQIAAFAMTIFFNE
MTMPERIALTCAMRDSGMVIDWSHMNFGGPIVDKHSTGGVGDVTSLMLGP
MVAACGGFVPMISGRGLGHTGGTLDKLEAIPGYNITPSNDVFGQVTKEAG
VAIIGQTGDLAPADKRVYATRDITATVDNISLITASILSKKLAAGLESLV
MDVKVGSGAFMPTYEASEELAKSIVAVANGAGTKTTAILTDMNQVLASSA
GNAVEVREAVRFLKGEYRNPRLLEVTMASCAEMLVLGKLAENTEDARAKL
MEVLDNGKAAECFGKMVAGLGGPVDFMDNYDNYLDKAEIIKPVYAKETGV
VSAMDTRAIGMAVVAMGGGRRVATDSIDYAVGFDQFIRLGEIASSEKPLA
MIHARNEAQWQEAANALQAAIKVGGEYTPTPDVYRQIRQEDI
>VV11723 Nucleoside permease
MSLVGMAVLLGIALLLSDNRKAINLRTVAGAFAIQFIIGGFVLYVPWGRD
LLAGFSAGVQNVIDYGKDGTGFLFGSLVNFSVDGIGFIFAFQVLPTLIFF
SALISVLYYIGVMQWVIKILGGGLQKALGTSRAESMSAAANIFVGQTEAP
LVVRPFVPKMTQSELFAVMCGGLASVAGGVLAGYASMGVPLEYLVAASFM
AAPGGLLFAKIIKPEVDTPNESLEDNIDGGDDKPANVIDAAAGGASVGLQ
LALNVGAMLLAFVGLIALVNGILGGVGGWFGMENLTLELILGLVVRAASI
PNRCSMG
>VV11861 Uridylate kinase
MTTNPKPAYQRILLKLSGEALQGSEGFGIDPTVLDRMAQEVKELVELGVQ
VGVVIGGGNLFRGAGLAQAGMNRVVGDHMGMLATVMNGLAMRDALHRAYV
NARVMSAIPLNGVCDDYNWADAIRELRQGRVVIFAAGTGNPFFTTDSAAC
LRGIEIEADVVLKATKVDGVFTADPVANPDAELYDKLSYTDVLEKELKVM
DLAAFTLARDHKMPIRVFNMNKPGALRRVVMGEAEGTLITA
>VV20531 Deoxycytidylate deaminase
MISKWAKRFYQMAELVASWSKDPSTQVGAVITKQNRIVSVGFNGYPHGVS
DSVDTDERELKYLKTLHAEENAILFSKRDLDGCEIWVTHFPCPNCAAKII
QTGISRVHCPEQSEDFLSRWGDKIAVSQDMFNQAGVEVNWLPVNELGEEG
VR
>VV11226 Phosphoribosylamine-glycine ligase
MNVLIIGSGGREHALGWKAAQNPNVETIFVAPGNAGTALEPKLENVNIAV
EDIAGLVAFAKEKAIELTIVGPEVPLVLGVVDAFYEAGLPIFGPTQAAAQ
LEGSKAFTKDFLARHQIPTAAYANFTDIEPALAYVREQGAPIVVKADGLA
AGKGVIVAMTLEEAEEAIKDMLAGNAFGEAGSRVVIEEFLDGEEASFIVM
VDGENVLPMATSQDHKRVGDKDTGPNTGGMGAYSPAPVVTPEIHNRVMQE
VIFPTVRGMAAEGNPYTGFLYAGLMIDKDGTPKVIEYNCRFGDPETQPIM
MRMESDLVELCLAAIDKKLDQVESKWDPRASIGIVLAAGGYPAAYNKGDV
ISGLPQVEIEGEKVFHAGTENKEGDIVTNGGRVLCATALGNSVSEAQQRA
YELAKQIRWEGMFHRNDIGYRAIAREQQK
>VV12771 5'-nucleotidase/2',3'-cyclic phosphodiesterase
MPWDYAADKLNMSGSLSQIATKVKAIRQEQNNVILVDAGDTIQGNFVETF
KEEPIDPMMLGFNEMNYDVWVLGNHEFDFGLNVLNRSLTQFKGTSLAGNI
QRPDGNPFLPGYTIIERGGIKIGVIGMDTPMTQVFAEGTNRLEGMTFTNP
TLEVKKIVKQIEGKVDAIVLVAHMGLDNENDIADTGVTDIANGNPELDAI
VAGHMHTRIDKAVVNGVIITEPDKYGRALSRIDLQFEEQNGQFTLINKDS
YTYKIKGVDSDDKMESLYEPYHKRLREMANREVAQLTGVNLVPENDIRGI
PQVHVQDSGISALFQEASFFYAPQANVIALQIDNDNAKLDVGPIKAKDIA
YNYQYAGGEITVYQMTGKELKQYMEWSAGYFNSVQAGDVTYSFNPERRAS
KYSTNDFFAGVTYTIDLTQQAGQRITDLKFADGKPVLDDSEIRLGMNSYR
MGHLTKKGGVLEGQTFPVLFDTEAKYGEEQGTIRNLTIRYLTEQKQGQYV
GQPMQRWKLSGLQGFEKEGAIVKQLINEGKIDVPASEDGRYTNIASINVK
ALVFTNPQAKNEAITSRLAKIEEANPTEKQHLKRELILIEALNP
>VV20629 IMP dehydrogenase/GMP reductase
MSSKSAMDKHSGGVAGYRAAEGKTVLLPYRGSVHGTIQDILGGVRSTCTY
VGAAELRELTKRTTFIRVLEQENNVFGKEK
>VV20892 Diadenosine tetraphosphate hydrolase
MATEQTCIICQIQQNKLTHFLIAEQDGFKAVLDKYPIAEGHILILSPSHA
SHLEQLSDSEYATLFQFARDIGQQMSHVYDGVCDYNVIINNGQYSGQHIP
HVHLHLIPRKKGDSVHFYWRLLTRFINPLSPMNTLARLKRVHQKWQQRIS
IVDSSKS
>VV21540 Purine-nucleoside phosphorylase
MATPHINAQPGDFAETVLMPGDPLRAKYIAETFLEDVKQVCDVRNMFGFT
GTYKGKKVSVMGHGMGIPSACIYVHELIAEYGVKNVIRVGSCGAVRDDVN
LMDVVIGMGASTDSKVNRIRFNDHDFAALADYGLLEEAVKQARAQNVPVK
VGNVFSADLFYTPEADIFEKMEKLGILGVDMEAAGIYGVAADLKAKALTI
LTVSDHIIRGEKLSSEDRQKSFNDMMKVALETAINL
>VV20217 Formyltetrahydrofolate synthetase
MLSDIDICRTTPLKPIEQIAAKAGLLADEFETHGLYKAKVSARCVKRLAE
QQDGKLVLVTAITPTPLGEGKTVTTIGLAQGLQSLNQSVMACIRQPSMGP
VFGVKGGAAGGGYSQVAPMDELNLHLTGDIHAVTAAHNLAAAAIDARIYH
EQRAGYQAFEARTGLPALRIDPDRVVWKRVMDHNDRALRKVRVGINDEGQ
DHQRI
>VV11725 Deoxyribose-phosphate aldolase
MSDLKAAALRALKLMDLTTLNDDDTDAKVIALCHDAKTPVGNTAAICIYP
RFIPIAKKTLREQGTPEVRIATVTNFPYGNDDIEIAVAETKAAVAYGADE
VDVVFPYRALMAGDEKVGFELVKQCKEACGDILLKVIIETGELKEEALIK
KASQICIEAGADFIKTSTGKVPVNATPEYARMMLEVIRDMGVAEKVGFKP
AGGVRTAEDAAAYLAMADDILGSEWADNMHYRFGASSLLTNLLNTLEVTD
QVADPAAY
>VV11728 Purine-nucleoside phosphorylase
MATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDVVQVCDVRNMYGFT
GTYKGRKVSVMGHGMGIPSCSIYATELIKDYGVKKIIRVGSCGAVSTDIK
VRDVVIGMGACTDSKVNRIRFKGHDFAAIADYKMVKAAEEAAKARGIDVK
VGNLFSAELFYTPDPEMFDVMDKYGIVGVEMEAAGIYGVAAEYGAKALTI
CTVSDHIKTGEQTTSEERQNTFNDMMIVALDSVLLGDAE
>VV20712 IMP dehydrogenase/GMP reductase
MRIEQELKLGFKDVLFRPKRSTLKSRSQVNLTREFTFKHSGRQWSGVPVI
AANMDSVGSFEMAKALSQHGVMTAIHKHYTVQDWADFVKDADSETLNKVM
VSTGTSEADFQKTKDVMALSDELIFICIDIANGYSEHLVQYVQQVRAAFP
DKVISAGNVVTGDMVEELILAGADIVKVGIGPGSVCTTRVKTGVGYPQLS
AIIECADAAHGLGGRIIGDGGCACAGDVAKAFGGGADFVMLGGMLAGHEE
SGGEIVLKDGESYMKFYGMSSKSAMDKHSGGVAGYRAAEGKTVLLPYRGS
VHGTIQDILGGVRSTCTYVGAAELRELTKRTTFIRVLEQENNVFGKEK
>VV10558 Nucleoside phosphorylase
MKVGIIGAMQQEVAILKEAMTNAQTVNKAGCTFYSGQINGVEVVLLQSGI
GKVAAAIGTTILLDEYQPDMVLNTGSAGGFDSSLNLGDVVISTEVRHHDA
DVTAFGYEMGQMAGQPAAFLADEKLMNLAEKALEQMDGQHAVRGLICTGD
AFVCTAERQAFIRQHFPSVIAVEMEASAIAQTCYQFKVPFVVVRAISDVA
DKESPMSFEEFLPLAAKSSSEMVFKMLELLK
>VV11123 Adenylate cyclase
MQAYTEKLIQRLDTLNRQRIERALALMDLQSQQVFHLIPVLLHFNHPAIP
GYFDADVPFGVHGLKLNDIQQQFVDDTELTLGQSLPRAPHAQILGLYTMG
STSSIGQSTSSDLDIWVCIPTQMGHDERESLANKCLLITDWAQMHGVEAN
FFLMDEDRFRSNRSEEMTGDNCGSSQHMLLLDEFYRSAVRLAGQRLLWQI
VPPEMEECYEQYVAELCNGGHINCNEWIDFGQLSRIPAEEYFGSNLWQLY
KSIDSPYKSVLKAILLEAYSWEYPHTQLLSIDSKRRFFAHEPDLYGMDAY
YLMLEKVTRYLERINDHTRLDLVRRCFYLKTHEKLSREPGVGSVAWRREA
LHELTSQWQWSQEVIVELDNRRNWKVEQVKVVHHALLDALMQSYRNLIQF
ARRNDITSAISPQDISILARKLYAAFEVLPGKVTLLNPQISPDLHEPDLS
FIEVREGRINKSGWYLYKQPLIAHRILGQPYLEHHEYLSKLVAWAFFNGL
ITESTRLHAVVREAQLDIDKFYQMVSDLRNTFSLRKRRPTMQALASPCEI
SQLAMFINFENDPTAELSGRSLKVDLKNADIFSFGTEQKCLIGSVDLVYR
NSWHEVRTLHFRGETAMLDALKTVLGKMHQDAIPPESVDVFCYSKNLRGV
MRNMVYQLLAECIDLRLKPVEQEKRRRFKAIRLAAQTFGLFFERRGVSVQ
KLENSVDFYRSISTNKLKGSPLLMLDREDDYHLPPVVDGFASEGLIQFFF
EDTEKGFNIYVLDEANQVEVYHQFSGSKDEMIASVNSFYTAVKDDKHVAS
KCINFNLPQYYQIIHPQEEGQESYIIPYRNDACTQTKMSKAVNV
>VV11724 Nucleoside permease
MSEKTQAIIAFALCGFANLSSIAILLGGLGSLAPARRHDIARMGVKAVAA
GTLSNLMAATIAGFFLSF
>VV11997 Glutamine phosphoribosylpyrophosphate amidotransferase
MCGIVGIVGTTPVNQSIYDALTVLQHRGQDAAGICTIESNRFRLRKANGL
VKDVFEAKHMQRLQGNVGIGHVRYPTAGSSSASEAQPFYVNSPFGISLAH
NGNLTNAHEVRQKLFEKDRRHVNTTSDSEVLLNVLAHEIDTVKGNVTADD
VFRAIANVHRTIRGAYAVTAMIIGHGMIAFRDPHGIRPLCLGKREENGQT
EYMVASESVALDAVGFDFVRDVAPGEAIYATFDGELFTKQCADNPKLNPC
IFEFVYFARPDSFIDKISVYSARVEMGKKLGERIKEEYADLDIDVVIPIP
ETSCDIALQIAQAIDKPYRQGFVKNRYVGRTFIMPGQQLRKKSVRRKLNA
IRSEFKDKNVLLVDDSIVRGTTSEQIIEMARDSGAKKVFIVSAAPEVRFP
NVYGIDMPSATELIAHGRDNETICKLIGADALIFQKLEDLVDAVGLGNLD
ITKFDTSVFNGEYVTGDIDQQYLDFLDSMRNDDAKVQREIQQDLANLELH
NEGA
>VV12521 Nucleoside permease
MTDIIEYISYLIAGILIAPFGFMLFKEFIGKDRKTVTDEVKSTVGDESRK
FLGGRYGDAVVGQFVEFKLIIAIGLPLVLFLGISSLVNSLLKVLFNL
>VV12637 Dihydroorotate dehydrogenase
MLYRLARAGFFQLDAEKAHDLAIQNFKRFTGTPIDLFYRQQLPNRPVECM
GLTFRNPVGLAAGLDKNGECIEAFDAMGFGFVEVGTVTPRAQSGNDKPRL
FRLVGAEGIINRMGFNNLGVDNLIENVKKAKYSCVLGINIGKNKDTPIEK
GAEDYLICMEKVYEYAGYIAVNISSPNTPGLRTLQYGEALDELLVELKRK
QAELEEKHGKYVPLALKIAPDLTDDEISQICQSLINNKIDGVIATNTTLD
RTMVEGMKHAQEAGGLSGRPLQSRSTEVVRLLRKELQGNIPIIGVGGVDS
YVAAKEKMLAGADLVQVYSGFIYHGPGLVRDIVKNL
>VV12983 Cytidylate kinase
MSSQTPVVTVDGPSGAGKGTLCMLLSKKLGFQLLDSGAIYRVLALAAIHH
GVDTESEDALVPLATHLDVQFVAEGDLVKVILEGEDVSKELRKEETGMAA
SKVAALPRVREALLRRQRAFEAAPGLVADGRDMGTVVFPNAKAKIFLDAS
AEERAHRRLKQLQDKGLDVRFDDLLSEIQERDDRDRNRPVAPLRPAEDAL
VLDSTSMSIDEVVEKALQYIESKLAE
>VV11900 Phosphoribosylaminoimidazole synthetase
MSGNNSSLSYKDAGVDIDAGNALVERIKGSVKRTRRPEVMGGIGGFGALC
ELPTKYKQPVLVSGTDGVGTKLRLALDMNKHDTIGIDLVAMCVNDLIVQG
AEPLFFLDYYATGKLDVDVAADVISGIAEGCIQAGCALIGGETAEMPGMY
EGEDYDVAGFCVGVVEKEDIIDGTKVAVGDALIAVGSSGPHSNGYSLVRK
ILEVSGADKNEELAGRTIGEHLLEPTKIYIKSALKMIEQHDIHAISHITG
GGFWENIPRVLPEGTKAVIDGKSWEWPVIFQWLQEKGNVATREMYRTFNC
GVGLIVALPQDQAEAAVALLQQEGEKAWVIGAIAQAEAGEEQVEIN
>VV21596 Dihydroorotase
MVGATMTTLTITRPDDWHVHLRDGEVLADTVRDISRYNGRALIMPNTVPP
VTTSEMALAYRDRIQAHNQTEQFSPLMSLYLTDNTTADEVRKAKASGAVV
AAKLYPAGATTNSDSGVTDVKKIYPVLQAMQEVGMLLLVHGEVTTHDVDI
FDREKTFLDNVLAPIVQDFPDLKIVLEHITTSDAVVFVKNANENVAATIT
AHHLLYNRNHMLVGGIKPHFYCLPILKRNTHQLALISAATSGNKKFFLGT
DSAPHAKGAKESACGCAGSYTAHAAVELYAEVFEQAGKLENLEAFASHNG
PDFYGLPRNQDTITLVKDAWPVPASMPFGGDIVVPIRAGENMEWKVK
>VV12002 Adenine/guanine phosphoribosyltransferase
MTTNTIAQIQASIKSIPDYPKPGILFRDVTSLLEDAQAYQATIQLLVDKY
KDMGFTKVVGTEARGFLFGAPLALQLGVGFVPVRKPGKLPRNTIAQSYEL
EYGVDTLEIHTDAIVEGDKVLVVDDLLATGGTIEATTKLIRQLGGVVEHA
AFVINLPEIGGDKRLEGLGLNVYSICEFEGH
>VV10329 Adenine/guanine phosphoribosyltransferase
MSNKFVITWDAMQTYCRQLAEKQMPADQWKGIWAVSRGGLVPGAILAREL
GIRYVDTICISSYDHDHQRDMTVLKAPEGDGEGYLIVEDLVDSGDTARKL
REMYPKAKLIAVCAKPSGKELLDDYVVDIAQDTWIEQPWDMALAYAEPVN
RKQK
>VV10188 Adenylate kinase
MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAIKAGTELGKQAK
AVIDAGQLVSDEIILGLIKERIAQEDCAKGFLLDGFPRTIPQADGLKEMG
VAVDYVIEFDVADDVIVERMAGRRAHLPSGRTYHVVYNPPKVEGKDDVTG
EDLVVRDDDKEETVRARLGVYHSQTAPLIEYYGKEAAEGNTKYLKFDGTK
QVAQVSADIEKALA
>VV12928 Adenylosuccinate lyase
MELSALTAVSPVDGRYGSKTIALREIFSEYGLLKYRTIVEIRWLQKLAAT
AEIAEVPAFSAEANQFLDDLAANFSEADALRIKEIERTTNHDVKAVEYFL
KEKVADVPELHAVNEFFHFACTSEDINNTSHALMLKEARETVILPEIRNL
IDAIKALAVEYRDIPLLSRTHGQPASPSTMGKEMANVAYRMERQYKQIEN
VEILAKINGAVGNYNAHLSAYPELDWHKFSEEFITESLGVTWNPYTTQIE
PHDYIAELFDAVARFNTILIDFDRDVWGYIALGHFKQKTIAGEIGSSTMP
HKVNPIDFENSEGNLGLANAVFGHLAQKLPISRWQRDLTDSTVLRNLGVG
VGYAIIAYTSTLKGISKLEVSREALLAELDKNWEVLAEPVQTVMRRYGIE
KPYEKLKELTRGKRVDGEAMRNFIDGLELPEHEKARLKEMTPANYIGQAI
ELTDKL
>VV10831 Orotate phosphoribosyltransferase
MKAYQREFIEFALEKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLARLG
RFYAAALADSGIEFDVLFGPAYKGIPIATTTAVALADHHDIDTPYCFNRK
EAKDHGEGGNLVGSALEGRIMLVDDVITAGTAIRESMEIIQANGADLAGV
LVAIDRQEKGKGELSAIQEVERDFACAVISIVSLSDLITFLEEKGDAAEH
LDAVKAYRAQYGI
>VV10418 GMP synthase, PP-ATPase domain/subunit
MTKNIHDQRILILDFGSQYTQLVARRVREIGVYCELWSWDVEEADIREFN
PDGIILSGGPESVTEDNSPRAPQYVFDSGVPVLGVCYGMQTMAEQLGGKV
STSDEREFGYAAVKVSGESAIFKDLEATQDVWMSHGDKVVEIPAGFTKVG
ETDTCPYAAMANEEKKYYGVQFHPEVTHTKNGLQMLENFVLGICGCERLW
TSESIIEDAVARIKEQVGDDEVILGLSGGVDSSVVAMLVHRAIGDKLTCV
FVDNGLLRLNEGQQVMDMFGDKFGLNIIKVDAEERFLKALEGKSDPEEKR
KTIGHVFVDVFDEESKKLKNAKWLAQGTIYPDVIESAASKTGKAHVIKSH
HNVGGLPDDMEMGLVEPLRELFKDEVRKIGLELGLPYEMLYRHPFPGPGL
GVRVLGEIKKEYCDLLRRADAIFIEELHAADLYNKVSQAFTVFLPVRSVG
VMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDFLGKVSNRIINEVNGIS
RVVYDISGKPPATIEWE
>VV10342 Cytosine/adenosine deaminase
MAETHQPFSLQDEVFMRRAIELAAIAESEGEVPVGAVLVKDGEVIAEGWN
QSIGQHDATAHAEIQTLRQAGQSLGNYRLLDTTLYVTLEPCPMCAGALLH
SRVKRIVFGAPDLKAGAAGTVLDLFSSQAAYHYATIEKGLLELECREQLQ
AFFKRRRKEIKALKKEQQTQSDHEDVDEEEK
>VV10248 5'-nucleotidase
MTMKQRLIVKTALSAAILATLAGCATQPTQEWAADTTYKLTVLHTNDHHG
RFWQNKYGEYGMAARKTLIDELRAEIQAEGGSVLLLSGGDINTGVPESDL
QDAEPDFKGMSKIGYDAMALGNHEFDNPLDVLMKQKEWANFPMLSANIYD
KKTGERMFQAYEMFDKQGIKIAVIGLTTEDTAKLGNPEFIGAIDFRDPKE
EAKKLIAELKETEKPDLIFAVTHMGHYEDGKRGINAPGDVALARYLNEGD
LDMIVGGHSQEPVCMEAPNVVKKNFKPADECKPDQQNGTYIVQAHEWGKY
VGRADYEFRNGELRMVSYDLIPVNLKKKVEVDGKSQRVFIESEIKEDTAL
LEFLRPYQEKGQEQLNVKIADTNGKLEGDRNVVRFQQTNLGRLIAVSHME
RAKADFAVMNSGGVRDSIEAGEVTYKDVLTVQPFANILTYTDMTGKEVLD
YLNVVATKPVDSGAYAQFAGISMTVANGKVSNVFIGGKQLRLDETYRFTV
PSYNAAGGDGYPKLTGHPGYVNTGFVDAEVLKEFLEKNSPIDVNKFAPNG
EIVYK
>VV20468 Adenosine deaminase
MNYFDLPKIDLHCHLDGSVRPQTIIDLADEQNLTLPSRDINVIKEMMVAP
ETCPNLDEYLKRFELPGMVMQTAEALERISFELFEDAANENVKYLEVRFG
PLLHQVKGLSLDDIMDSVVRGMKRAEAQYDIHGNYILSILRTMPKDQIKA
VLEAGAKHLNDGIVAFDLAGSEVPGFCHEFVPYAQYAKELGYRITIHAGE
QGAGQNVYDAISLLGAERVGHGIFIHNHPEAYQLVKGEEVALETCPSSNV
QTKAVNSLSEHPIKAFYKDGIAVTINTDNRTVSNTTMTDEVRKVVEAFEL
TEAEYFDIYTISVNNAFTSDAVKQHLLSFAQ
>VV20337 Oxygen-sensitive ribonucleoside-triphosphate reductase
MKPIVIKRDGSRAPFSRDRIQAAVEAAAENVDKEIAIYALNVALAVELQL
KDHDEVHIHEIQTRVENELMQGPYKSLARAYIEYRHDRDIAREKQSTLTR
EIEGLIEESNVDLINENANKDGKVIPTQRDLLAGIVAKHYAKTHILPRDV
VQAHDEGDIHYHDLDYAPFFPMFNCMLIDLKGMLTHGFKMGNAEIDTPKS
ISTATAVTAQIIAQVASHIYGGTTINRIDEILEPYVNASYEKHLKIAQEW
DIHNPEGFAIARTEKECYDAFQSLEYEVNTLHTANGQTPFVTFGFGLGTS
WASKLIQQSILKNRIAGLGKNRKTAVFPKLVFAIKDGLNHKPTDPNYDIK
QLALECASKRMYPDILNYDKVVEITGSFKTPMGCRSFLGTYEENGELIHE
GRNNLGVVSLNLPRIALKANGDEEKFYALLDEKLKLARRALETRISRLEN
VKARVAPILYMEGACGVRLKADQPIADIFKHGRASISLGYIGIHETINAL
FGNQTHVYDDNELREKALNIVKRMKKAVEAWSEETGYGFSLYGTPSENLC
SRFCRIDTKEFGVIEGVTDKGYYTNSFHLDVEKKVNPYDKIDFEMPYPEI
SSGGFICYGEFPNMQKNIEALENVWDYSYSKVPYYGTNTPIDECYECGYT
GEFDCTSKGFTCPKCGNHDSSKVSVTRRVCGYLGSPDARPFNFGKQEEVK
RRVKHL
>VV11635 Hypoxanthine phosphoribosyltransferase
MKHTVEVMISEQTVQERVRELGKQITAHYQGSEDLVLVGLLRGSFVFMAD
LARAIELTHQVDFMTAS
>VV10257 Phosphoribosylpyrophosphate synthetase
MKLFAGNATPELAQRIADRLYISLGDATVSRFSDGEVAVQINENVRGSDV
FIIQSTCAPTNDNLMELVVMIDAMRRASAGRITAVIPYFGYARQDRRVRS
ARVPITAKVVADFLSNVGVDRVLTIDLHAEQIQGFFDVPVDNIFGTPVLL
EDMHARGLEDPVVVSPDLGGVVRARATAKALGDIDIAIVDKRRPRANVSE
VMNLIGDVEGRDCVIVDDMIDTGGTLCKAAEALKERGAKRVFAYATHAVF
SGNAAKNIKNSVLDQVIVTDSITLSKEMAATGKVTQLTLSGMLAEAIRRI
SNEESISAMFN
>VV10302 DNA/RNA endonuclease G
MKNLILLSLLFALPAAAEICGQHLDKGMPSTQPDQVLCRDGYAVGYNYNT
KNADWVAYHITAESVNASYKRSNSFKEDAELPDYARSTLADYSNSGYDRG
HLAPSAAMDFSQQSMQQSFLMSNMSPQLPGFNRVGWRFLEEHVRDLANEY
NELYVVTGPIYQGGENAIGNGVVIPSAFFKVILDPAFNDAIAFVVPHRDV
SGSELANFITTIDEVERLTQLDFFSAVDDSTEASMEAQVWEMWPTSN