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# Leptospira interrogans serovar Lai str. 56601, 56601

>LA1539 Orotate phosphoribosyltransferase
MKKRIVSTVLGLAIFAGTSLISNRAEAKGYGEAGCGLGSILISSKGFVQI
FAATSNGTSGNQTFGITSGTSNCTADGIVKLEKAQEMFVTVNYESLEQEM
AIGKGEKLESFAKLLGCDAGSVSRFGKLTKEKYSSLIKQETTPSLLLSAV
KSEVKGDTSLSKNCTL
>LA2598 guanylate kinase
MDIDVQGAKIIKEKLPDKIVTIFILPPNEKEWEKRLRGRGTDSEENILKR
IQNGKLELERQNEFDYKIVNDNLDRALAELENIILKSESKSTTEK
>LA2044 HIT family hydrolase
MCVMEDSNSTQWDEPRKNLFSIHKLDYARGKRPDVDCILCGICRKDPEVP
NLTVAETNFTIVSVNLYPYNPGHLIVFPKRHILSYEELTKEEAMEIHEGT
VKAISILKKLWNVQGFNLGYNLGKNSGGSIPHIHEHIVPRFPNEAGFLDV
LANSRIVIYEPYEMQKEWIRIWKEFS
>LA2600 hypothetical protein
MLLETCREKSMELFAVFAINAVVSVVLYYTITSKVTERIRTHMLGKINEE
IRDFIDELETESLRQVDLMGARILTFKEITSKAEELVKRIEQSTSPDILE
KIQIVDKDSVINNENKRSENLYPLKNGNHTGVSDSVQQGVGHIYKENLDL
TREDAENFPNLQKVSNSKIHTSYIQKLETTSKVVKKEVVSQNKPEILPQG
STSNLVLETIGKGIRKFFGIQEIKTIRSENETSGNDFFPGTRNSTLDISL
DENPFAPISESKLNETSSLVFKDNLKPKEADFGRILQENIVGYQPIKPDS
TKISAEAALLEIGDDSTKIEKVVFLLKRKYTHEEISEVLDLALGEVDIIE
RFRLDRNRRF
>LA3690 hypothetical protein
MHSHFFDYVNSSQFKERTILFLGEFSIGPIYRIDTIEGQKIRQEWISKNL
SYHPKDYYAKDFFSSFLKFTEEVRSIPKENKIAIWKSKNTESYLGLCFAL
SILGDRDQIRVIDLSEANRKILQKNYEIRFAGEVSPEDLERIRKASEKNE
YLSEEMKMNLIKKWQFFSESKDILRIWKDDQVHSIPEDYYDDFIVAYAKK
IGAEKDFYTATKLIGSVLYHSANDLSESHTSCDAFFDYRIRILIKRGVFE
AQDIFKPDLKYKIKLIS
>LA1436 HIT family hydrolase
MYGEFRMTDPNCIFCKIIRKEIPSKVVFENDEILAFYDISPQAPVHIVFI
PKKHIPSLSEIENEDSHLLGNILLQIRDTAKNLGFAENGYRVVNNTGKNG
GQTVFHIHFHLLAERRLHWPPG
>LA1533 conserved hypothetical protein
MITSEKSIEIRDKVAKSTKKAGHLTTRQHPQFIFTLDKVSRQFVWSFLHS
HPFYNSEQVSQRYVEVKKENYYIPPELDGKLLELYLDAVDFASQSYFSYT
EALHPFIQEEYFQIYKARANYPDKWQTPIKKKCLEVARYLLPLGTFTYLY
HSVNGLTLHRYYRLMNSYDVPNEQRAVITEMINQVRAIDPLYADEMDDPV
PLEETTEYRYFDSMFGNGKREFHPETASTFVKEFDLELGERYSKLVSHSS
NGPEILAQSVRSILGIPKSILNDQDAIDLVLNPAKNRHLTSTLNESSMSP
ITRALFNVQYSFQKRISHTADSQDQRHRMVPGGRPVLMSQYAGIPDYITP
FVVQKYPELKEKYDVVHREIFEKLNRFLEAGGSPEHGTYLLPNSFPIRFY
ESGDLLNLHHKWRSRTCYNAQEEIFQASVDELTDVMKVHPQIAKWIKAPC
WIRLQGEVKPYCPEGDHYCGTQVWKRELSEYSRVI
>LA1121 hypothetical protein
MDILLLDDGQKIQSSLIEGSVGTDSLLVPGVYWNRLNLQEKKALRNKLPF
LLRKYSKQIASMKRLHNKAGKIKYNRGVGKMKKLSIRVHSGVWATLGVLA
AAHGVSRCYLFNYMLWLDEQGDFFVKTLNRGVPSFHWTYKMIWKIDRRQN
FISRELQFEPNPMTNQYPYYLKE
>LA0760 adenylate kinase
MKNIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEA
KRYMDAGDLVPDSVVIGIIKDRIREADCKNGFLLDGFPRTVEQAEALDTL
LKNEGKSIDKAINLQVPDAELLKRLLGRAEIEGRADDNEVTIKNRLDNYN
KKTLPLLDFYATRKKLSQVNGVGSLEEVTSLIQKELA
>LA3969 Adenosine deaminase
MKPYADLHNHLYGSITSEFLYELGKSNPSPRWEIFTSSYLQCFGKKISTE
TFFQDYQDPDSFRKFYQFNHRGPFTEFQAKFNLIIALSKFDPAEISLVAT
RVVENQFLQGVTYGEYRLMYSPLETEIGIYEKTLAACEGLALGEQKTGGL
AKGKLVISLHRDGDIFQEYLIYKNIMEKNSLIRNYLVGLDFCYIEEGFPP
KGKRKFFQEVNRDNQAEKNTALAILYHVGESFQDKSILSASRWVLESAEW
GAHRLGHAIALGLHPSEKMKDEITEPRSERLDQLQLYYDRKEELDSYFEV
PSREKIGNEIDSLKHKETVKFNISPSFLEECIGFQNYCISKIKQTNAIIE
SCPSSNEYIGMVVNPESHPILRFAKNDMKFTISTDDPGIFGTSIKEEFSK
AAKIGLSTEVLETVRRNSFLFTSEILSGKKSSSEFEVLESF
>LA4168 Nucleoside diphosphate kinase
MSRTFIMIKPDGVKNKHVGNILSRIEKEGFKILGLKYLKLSLEDAKQFYK
VHSARPFYNDLCNYMSSGPIVAAALERDNAVLHWREVIGATDPKEAAAGT
IRALYAESKEANAVHGSDSDDNAALEISFFFKGNELF
>LA3783 Adenosine deaminase
MALTFQEILDRIRIIDRDVTELNRLKSRLPADRPYSSSLQISFDKQINEL
LNERVGLMELEVLDPPSWILGVPTTGISQETPVPLKGLFPSGDLSKEKPD
DQDVINFLRELPKTEIHLHLEACVNKDTMKRLMAKNGINVTDEEFEAKFN
FKDLNSFIQVFFFIQSLVKEPSDFSFFIESLAEYMRANNILYTEVFFAPS
KFIQNGLDFEEMIDFLVNRIREEKENDGIVIRLLVDVSRSFGPENAMKNL
DRVLKLRHPEVIGIGLGGAELMGPARDYQGVFQKAREAGLRVVAHSGEDD
GPWAIWEAVELLKAERIGHGTSAIQDPELVKYLRENHIPIEICVTSNVFT
GKYVRKEQNHPVRYYYDQGLPLSINTDDPEIFNVNLTYEYYKLWRFLDFS
LDEIVDLIRQGVFASFHPNKESLWAEMEKNIHLVKTRYGLKR
>LA1959 probable glutamine amidotransferase
MRSLIVRFKDCEGPGILLNSLKKRNYKITYHNAYDLRVKPLPDAHLVFDL
IVLLGGPQSVTDHSLADFFEPWLNLVRYAKSIPNCKVIGICLGSQIISKA
LGGEVKRGENGPEVGFYDVQVQEPHFLFDGISSFPAFHLHEDVFSIPEGT
KRLLKSEKYSNQMFSFEDRIFGIQCHLETTASMLSIWQKAHSDFIRSAGW
IPGPETEFLRSQMEKVGGSIFEKILDHSTGFETNHRALLSSQAMTAKSG
>LA0311 probable chlorohydrolase
MEYELVNACIVTKDRWISNGSIVIKDGIIASVNAGGPPAGKRIRLNLNGL
YVYPGLINGHDHLLSTYLPRVAPSKPYLNWLPWDNDLKSSIVFSERQQLD
PEQLYLLGSYKNLISGVTSVQDHIPHFVQDPFIETMPVRILNRFTLSHSI
CTYSLDWGDGPEEEYAKALKQDIPYITCIAEGFDSESRDSLKNLYQLGCL
GEHTVLVHGIVLSESDITLIAQKKSHLVWCPEANLFLYERTTDIKDVLKH
GVNVCLGTDSSICGSLNLLEEIKNARKFYQTEYGEDLSPKTLFEMVTSNP
AKAFRIEKQLGSIEVGKIADLTILTRNFEDPYLNLCESNLNSIRLVLRDG
LPVYGDISLKSFFEESGVRVEKISIENAEKYLVASPGKLLESLVVSLGYK
KDLAFFPVQKEFDNFE
>LA0072 probable dCTP deaminase dcd
MILTGKEIQKRIGNDIVITPYSEKQLNPNSYNLRLHEELLVYTELPLDMK
KPNPAEKLVIPESGLLLKPGILYLGRTLESTETHNLVPMLEGRSSIGRLG
MLVHVTAGFGDVGFKGFWTLEISVIQPLIVYPGVEVCQIFYHTLEGQITE
YTSGKYQANRGIQTSMLYKDFEK
>LA3606 unknown protein
MSAKGISKDLIGTKLDHYEFDVERGKIREFCQAIGETNPIYFDVEAAKKA
GYEDTPAPPTYPTVIQFWGYPKIWQDMENMGVDTSRILHLKEKYTYLKPI
YPGRVSSQGECINVTVGKMDTMTFKTTIKNAKGETIVEQEMSIFIRKPEA
>LA2182 hypothetical protein
MCYYNWIFIRSLFRFLLYKIRISKIITDFIYYLVLTMSDCTICNFHQSCD
SSEILARFGEFSVRHSEQEKKLKGYLYIEPRSHWTSYLDWSQESFLDFGK
ALEFATNWIYKNHSPVKIYTVTVSEMVPHMHFHLIPRYSDDLKGIDYIKL
SLQGKLLEDQSIRDL
>LA1119 Deoxyuridine 5'-triphosphate nucleotidohydrolase
MKIFVQKLRPNAELPLLQTKQAAGYDIHACLDSKLVLEPGNVGLVPTGLS
FAIPQEFHFEIRPRSGFSTKNRILIPNSPGTIDSDYRGELMIPLLNLGDS
SFIIEHGMRIAQLLIRKTWYADWELVSEFADRTERGANGFGSTGH
>LA2274 Deoxyguanosinetriphosphate triphosphohydrolase
MYFSRDDLLQKETETLAPYAISNANNGGRIYEEEEHSYRLPFQRDRDRIL
HSSAFKRLQYKTQVFIFSVGENYRNRMTHTLEVAGLSRTIASALGLNSLL
SESIALAHDLGHTPFGHAGQEILSGLMKDYGGFEHNKQSLRIVTSIEKKY
PNFPGLNLCRETLKGLMKHGADYDSSVILLERKENGPSLEGMIADLSDEI
AYTNHDIEDGWEMGYLHLGDLLENPFWKEVYEECKDQYKEVGEKILIRTS
IRTLTNFLVSDLIQNIAHRLEKKQIKSTEDLALLWKQDFRIASFSKEVDL
KFRELKSFLYEKLYRHEDLIRMSDYGKKIIESLFDYFLKHPEKIPDTYKE
RIEEESLYRVISDYVAGMTDRYAEKIYQSLP
>LA0300 MutT/nudix family protein
MKYCSSCGSSVTYKIPEGDNRSRHVCDQCGTIHYQNPKIIVGSIPIWENR
ILLCRRAIEPRKGFWTLPAGFLENRETVEEGAIRETKEEANAEINILGLQ
SVYSIPHISQIYMFFLANLVNGKFSVSSESEEIKLFSIEEIPWEELAFTS
VSFALRKYVDSSVKNSLHLGNTRDRKNLPKES
>LA1053 hypothetical protein
MNGIWDPKKLNVNCNGRDVSGMSQSDGFFKIEPVTKEYILSQVGIKGDWN
ISEIYDGRVKLSIALMGDSPENEFFFAMGEERLPCVFTIKDKSDGGMLGF
SAQGRVWERPNIEKGKEYKDKTWVFLLPDYKGVLTA
>LA2087 GMP synthase
MKLLGGVVERSGTGEYGPASLQLHGTNGNSILKNFVGGEQVWMNHADEVV
KLPEGFSKIAFSKDCGYAVVANSSKKIFGIQFHAEVSHSEKGSVLLDNFI
QICGVSKTWGIDQFLKEKIKEIQETVKQEQKIFMLVSGGVDSTVSYLLLC
KALGAERVLGFLIDTGFMRKDEVVSLQKKLTFQNIHLTVRDESSLFYKSL
KDKSDPEEKRKIVGNLFLEARDRAVKDLDLEYGDWLLGQGTIYPDTIESG
GTKHSHTIKTHHNRVEAIQKLIEQGKVIEPIRDLYKDEVRDLGVLLGLES
EWVGRHPFPGPGLVVRMLAVEKKGTDKDQLEIDSYLSTQDGLSGKILPIA
SVGVKGDRRSYANCVVLNDIETDWNTLDRVATHLSNRFSFINRVVLLPFE
SDLKKWNFQFTGMQLDKKCSDLLREADFTVESVIRKLGLYNKIWQMPVVL
LPIGEKENEKSIVLRPVESQEAMTANFFRMERSVLQEIKIEVLKIPEIRY
LFFDLTNKPPGTIEWE
>LA0227 conserved hypothetical protein
MIFISVALFAEAKPLIENLGLNILRNKTVFPIYQNENHALVISGTGKIYS
AMSVVFLLNEFKDQISDSSWILNFGVCGARKDISEIGKSFLIHKITDEGS
FKNVYPDILFHSPIPESALRTFDKPIFDDVVSELPNTLVDMEAFGFFTAS
RKFFSSDKIRVVKIVSDNLNKLEYSKIKNIPKMISFRIQNSLSDILSILS
IPVFQKNNIQLLAEETSTLLQICEVLRLSETERIQLKDWMIGYKMRTGNS
PDLGLSILKNSNGFLKPGQTKVKTRELGKKGLYALKQFYQS
>LA4295 Hypoxanthine-guanine phosphoribosyltransferase
MKKINSDILHPRFSREDISQKVKSLALQISEDYKKLNPIFICVLKGGVYF
FTDLTREIPFSVEINFVQARSYSGTVSTGKIELLKDIDIDLSDRHVIIVE
DILDTGFTLQYLVRHIFTRNPASLEIVTLLLKERKDTLEFPVKYIGWRIP
DEFLVGYGLDFDGRYRNLPDIHVLEPGEPQFPV
>LA2519 hypothetical protein
MRKFNGTEFYSFLFKSGCTMIEKIIEDFKDSVKESVKSVRIPLEVHSKTG
NYSAEIGGWEGTSMSLNLERFNLDSVGEPATLEVKIPFWKDPILLHGTIT
EKKIVRSRSQDRMTDNVLLFESDAIGLVKKFLPKFPLDLKEWKLLEFSKK
AVLHSYFPKNLRMWELI
>LA1994 hypothetical protein
MEMSNLCSEVKKDFHKLENRFDVSYSTLRNKIDVLIDSLAIRFINDVPRK
KRIPG
>LA0404 Predicted HD family protein
MKIQWFHYENEGYYLSVKNLNEPIESLNPLYLRITHFNQNIDKIIGFILD
RYLQYLDIGPLRECIFSILRETLMNAIKANQKRMVFKEAGLDIKDPDQYL
IGMERFKEELISKKDLYADLLEQNGLYVLITFGFNQNSFLLKVSNNVGIL
PEEDQRIQERISKARSYNDLSEVFENHGDESEGAGLGLAMSLLMLKNEGI
EGDSYRIKSEEGITSAYIKIPFEFKKRNINLQKTGDIFAELDTLPTFPDN
INQIMSLINKPDSSIQNITELVSRDVSLSTNILKLANSASFSQRARVEDL
EDAIKVIGLSELNNILLSLGTKKILEEKYNEFEAIWERSSLSAFICRRLG
ERMGWKKQTITVLVCAALLHDVGRVILLSIDPNVSAKISEILGNRLYPSP
LTLEEAALGISHTTLGGMICEKWNFSDTIRVAAEMHHRPLLVKREFQDTV
FAIYLSDMIIDISSGISDYSMIQSAVLQHFGFKKEEEFVEFMDKTLLEYK
NFP
>LA2761 Exopolyphosphatase
MVQEKPLAAIDLGTNSFHMIIVRVRTNGTFEAIAREKESVRLGNRLQENG
PIDPESFRRGIDCLKRFKILAENAGAEIRAVATSALREASNQEDFLENAY
QEAGISIDVVSGYEEARLIYFGILQGIPVFDRKIMMIDIGGGSTEILVGH
RGNILFSKSFKLGAIRLSEKFFKEETLSNSDVRKCRLYIEEMLLPFRKIL
RDLKPDLVVGSSGTIQSIAGMILASRGETEEISLNNFSFTSSEFKKIRNL
ILEADTSKKRSKIPGLDSKRADIIVGGTLILEEIFDLANVSALTVSEFAL
REGIVYDTIRKWEHFENTEHSKHLDDIRQTAVHNFMKSFSRDEEFSKHVA
ELSLQIFDQLKSLHKLGQEQRELLEAASLLHEIGQSISHSAYHKHSYYMI
RNSEMLLGFTFLEIEIIALTARYHRKNTPKVKHREFNKLAEKNQTLVCQL
SAILRISSALNRNRGGLVSSVICKIEKNQIRFILESSKGYDPSLEIWAAE
EQKVAFEETFGYSVEFVTGT
>LA1259 Cytidylate kinase
MTKLLGLRLLFLVLKSYSRVVSMNENVIALDGPAGSGKSTVARQIAEKIG
FNYLDTGAFYRALTLYLFRLYQTSPNNRFEEWVKTSEAERSLSQIRIVCE
FSAGNENRILLDGEDVSLAIRTPEITREIKHIANRRIYRDFVNKELHSLA
KLHKLIMDGRDIGTEVFPDAKFKFYLTASSKVRAERRFLQLQEQGIFADR
NEIEKEIILRDKSDMEREIAPLYQAKDAILIDTDILSKNSVISKILEILD
Q
>LA4248 probable Methylthioadenosine phosphorylase
MSYNVRAAIIGGTGLYSLEGMELIEEIFPDTPWGKPSDKIKIGKYKGKLI
AFLPRHGIGHFLSPPEVPNHANICALKQLGVEEIVAFSSVGSLREEIKPL
DFVLPSQIIDRTRFRNSTYFGNGVVAHAPFAEPFSPNLSKRIAQTAKKIG
LEIHLDKTLVCMEGPLFSTKAESHLYRSWGADIINMTVLPEAKLAREAEI
AYQMICMSTDYDCWREGEESVTVEMVIANLTKNAETAKKLLSELIHVLGN
GDDLSLKNSTRYSIITAPEKRNSETVKKLRVLFPEYF
>LB176 adenine phosphoribosyltransferase
MSIVKSKIRTIPDYPKPGILFRDITSLLLDPEGLALTIGTFVNRYQGKGI
TKVAGIEARGFLTGAPLAFQLGVGFIPIRKKGKLPSETVSEEYDLEYGKD
VIEVHKDSIQPGDKILLMDDLIATGGTMIAAVKLLKKLGAEIYEAGVIID
LPDLGGRKKLQEELKVPVFSICEFEGH
>LA0806 thymidylate kinase
MNSDKNVLLDRYMYSTAAYQSGDDLSPEMILKKNLNRNFKIPDLLFYLDL
SPSIALERLNRRKEGKERFETLAQLEKIRSAYEKILPKDTIRIDGNKNQN
QIVQECLEIFLTNIKSKS
>LA3666 Xanthosine triphosphate pyrophosphatase
MKRQLALGTNNLNKVKEVSSILMELGIQILTPKDLKVSFNPEETGSTFKE
NALIKAKELFYLTKIPSIADDSGICVSALKDEPGVYSARFGGPELNDEGR
ALLLLEKLKGNQNRKAYYACAIAYVDESTEQSFEGRCEGLISEEYDRIGI
YGFGYDPIFIFPPLQKPFSQIQEETKNSVSHRKKALDELLKFLKTKP
>LA3512 unknown protein
MYIAKIQVVLKESVLDPQGSTVKKVLSEVGEKSVQDVRVGKYIELKIDAP
SEEVARKDVERLCDKILVNHIIETYSMNIQKI
>LA1239 carA, Carbamoyl-phosphate synthase small chain
MMKAFLVLDNGTIFEGESFGYETESVGEIVFNTSMAGYQEILTDPSYCNQ
IITLTYPMIGNYGIHPDNMESSKIQASGLIVKEYVDLPSNFKSEKTLSQF
LKEYKIPAIQGIDTRKLTRFIRTNGSPNGGIFVASEYSPSFLEKVKSFPG
IINADLAKVVTTSSKYIFGTHTGKKFKLAVYDYGVKTNILRLLDANGFAV
TVYPAKTPSEEIMKEGTDAFFLSNGPGDPAPLDYAIASTQKIMEKRYPLF
GICLGHQIIGLSLGKKTEKMKFGHRGGNQPVKNLETGQVEITSQNHGFAV
IDDQKQDEPISFLNLNDHTVEGILKSGYPLLTVQYHPESAPGPNDSRYLF
QKFYDLVEKTKKG
>LA0727 carB, carbamoyl-phosphate synthase, large subunit
MPRREDIRSVLILGSGPIVIGQACEFDYSGTQAAKALKEKGIRVILLNSN
PATIMTDPDLADATYVEPMTVPVVQKILEKEKPDAILPTVGGQTALNLAL
ACNSAGILEKYNVELIGAKVDAIKKAEDRELFKKAMEKIGVRVPASGLAN
NLKDAVEIKNKLGLPLIVRPAFTLGGTGGGIAYTEETFEEVVSKGLKASP
ISQVLLEESVLGWKEFELEVMRDLADNVVIICSIENIDPMGVHTGDSITV
APQQTLSDKEYQNLRDMSIAIIREIGVETGGSNIQFAVNPTNGDVIVIEM
NPRVSRSSALASKATGFPIAKIAALLSIGYTLDEIKNDITRVTPASFEPS
IDYVVTKVPRFAFEKFPGTDDTLGVQMKAVGEAMAIGRTFKESFQKALRS
LEIDRYGFGSDGYFQELLYSRSLNNDQRKEWIDSHLKRPNDKRIFYVKLA
FDEGYTVDQIHDLCKIDRWFLWQMEGLLKLEKEYSEKGNSILYKMKQVGF
SNRQLSFLKNKKQILDLLDGNLRVDLKKTEIQNLLKLSEEEIEVELGSKK
ILPVYKRIDTCAGEFEAYTPYFYSSYDEEDESDVTNAKSVMILGGGPNRI
GQGIEFDYCCCQASYALQDLGIESIMINSNPETVSTDYDTSDRLYFEPLT
LEDVYRIYQNEKPEGVIIQFGGQTPLKLAKDLEKKGVKILGTSPDSIDRA
EDRKRFVEVLEKLKLNSPESGIATSMEEAREIAHKIGYPVLVRPSYVLGG
RAMLIINEEKELDRYMEKAEEISKDRPLLIDSFLEDAIEVDVDALCDGKE
VFVTGIMEHIEEAGIHSGDSACVLPPQTLSKNMMDEIRKATVNLALELQV
KGLINIQYAVKNEILYIIEVNPRASRTVPFVSKALGHPIVKYATRIMMGE
SLKSLPLPKEMEFSQVSVKEVVLPFNKFPGVDTILGPEMRSTGEVMGIAS
TAGEAFLKSQYMAGDELPSQGTVFVSINDKTKAELLSYIKDLSELGFNLI
ATSGTHKFLSDNGILSSKINKVYDGIFPTALDYIRENKIHLIINTPLSRV
TRDDSFTIRQAAIRFKVPCLTTSNAAKALIKGMVEMKNKGFTIHSLQEIH
AMPKIL
>LA4330 codA, cytosine deaminase
MSKSPSDQNLSGKKSDSDQKKVKTEFLISKNIESDSITFQLSTKEDSVIR
TDNKILSDFLNKLENLVTRDREEIPSFTRIYHKEKLISETFNEVEKKSDS
SFHSEILCIRNAKEKLKTRYLADCMLITSLEPCLMCAGTILLSRIPKVVY
LLPAKQGEGISSLSIEMIYSRNFFPELFCIPTEISKNAFKSFFKVRRKKF
N
>LA2360 nrdA, Ribonucleoside-diphosphate reductase alpha chain
MLWSKKKFMKMNRHFTVPQNGESSTIQWTKRNSKITNPDGSKVFEANDIL
VPEDWSQVAVDILAQKYFRRKGVPKYLKKVQEDGIPEWLQKSIPDTEKLE
SLKPEDRFGGETSALEVFHRLAGCWTYWGYKYKYFSDEESAKIFYDEIVY
MLATQMAAPNSPQWFNTGLNWAYGIDGKSQGHYYVDPSTGKLVKSTSAYE
HPQPHACFIQSVDDDLVNEGGIMDLWVREARLFKYGSGTGTNFSNLRGEN
EPLSGGGKSSGLMSFLKIGDRAAGAIKSGGTTRRAAKMVCLDVDHPDIEN
FIDWKVTEEKKVASLVTGSMLNNRHLNAIMSACYEMEGEDRFNPKKNSSL
KKTIQDAKKVLIPDNYIKRVIDLARQGYKEILFEELTTDWQSDAYNTVSG
QNSNNSIRLTNEFMAAVEQDQPWNLYFRTEKEKAKVEGRKAKPSQTLRAR
ELWEKISYAAWASADPGTQYHTTINEWHTCPEDGPINASNPCSEYMFLDN
TACNLASANLQKFVNLETLNFDVEGFRYLCKLWTIILEISVTMAQFPSKE
IAELSYKFRTLGLGYANLGSVLMVLGIPYDSQQAMAITGAISSIMHMTAY
ATSAEMAKEQGPFVGYAKNQKHMLRVIRNHRRAAYNAPSGDYEGLTITPI
GINPAFCPSYMLKAAQEDADLALSLGEKYGFRNAQVTVIAPTGTIGLVMD
CDTTGIEPDFTLVKFKKLAGGGYFKIINQSVPYGLKKLGYSPSEIEAIVN
YCKGHATLNGAPVINTQALKEKGFTNEILEKVEASLPLAFDINFAFNKFN
LGENFLTKNLGISKEIFDSPGFSLLEHLGFTKEDINKANDYVCGTMTIEN
APFLKEKDYPVFDCANKCGKYGKRFLSYESHIRIMAAAQPFISGAISKTI
NLPEEAVIEDIKNAYFLSWKMMIKANALYRDGSKLSQPLNSVLELLNGIE
IDDQEEIREATISKDPVQIAEKIVTKYISHRRKLPSRRAGYTQKAIVGGH
KVYLRTGEYEDGQIGEIFIDMHKEGAAFRSLMNAFAISVSLGLQHGVPLE
EYVDAFTFFKFEPNGIVSGNKHIKMSTSVIDYIFRELAITYLGRYDLGQV
APEDLRGDEIGSKRATAESNGQEKETLSSMTAVIEPTPKKEVETISYSQM
ISKEKPSSSPSGISLLEEVKLAKIKGYTGDSCSECGSFEMVRNGSCLKCM
SCGSTTGCS
>LA3822 prsA, Ribose-phosphate pyrophosphokinase
MNGDIAVFAGNSNKQIAEEICTHLGIQSGKINLKKFSDGEISVKIEDNVR
GKEVFIVQSTSAPANDHLMELILIMDALRRASVSSISVVIPYYGYGRQDR
KVEPRVPISARVVADLIEVVGLDRILTMDLHADQIQGFFRVPVDNLHFAP
VLAEYVNTKKIDDLVIVSPDSGGAERARAFGKKVNGSLAIIDKRRPKANV
SEVMNVIGEIEGKNCILLDDMIDTAGTICKAADALLKHGAKSVYCAATHG
VLSGEAVDRINSTQFSEVVLANTIAIPESKKINKLKSLSVAPLFANAIQR
IHTNQSVSTLFD
>LA1110 purA, adenylosuccinate synthetase
MPASLVVGTQWGDEGKAKVIDFLSKDTDIIVRYQGGANAGHTVVVHGKKY
VFHLVPSGVIYDQTICVIGNGVVLDPLFFIEECDRLQKEGFPVFDKLLLS
DACHLLFPYHSQIDSARETTLSQEHKIGTTKKGIGICYADKMMRTGLRVG
DLLDTSYQTRLKHLVDEKNRELDKLYGMPPVSYNDINEGLKFFLSKVKKN
IINTAYYLDTELKKGKRVLLEGAQGTGLDVDFGTYPYVTSSNPTTGGALI
GTGIPFQHLKHVIGITKAYTTRVGEGPFPTELLGEAGEKLRQKGGEFGAT
TGRPRRCGWFDVEMLKHSVRINGITSIALTKIDILSDYDTIPVATGYKLN
GKTLDCFPSQGLDKVEVIYEEFPGWKSDISGICEFQKLPEKCKNYISALE
KWIGVKINLVSTGPDRKDTIHGDSF
>LA3080 purB, adenylosuccinate lyase
MIDRYSNPEISKIWELENKFEIWKEIEILACEIRMKRGEVPQEDFQEIKS
KAKFNVDEILEIESKVHHDVIAFLTNMNSYIGPAGRHVHYGLTSSDIGDT
ALCVQMVQAMDLILKKTDSLIEVVREKAIQYKNLPCIGRSHGIHAEPMTL
GLKFALFFEELNRNRKRMAEARNEIAVGKLSGAVGTYSNIDPEIETYVCE
KMGLRVDPIATQVVSRDRHAFYLSVLGVTASSLDRMATEIRLLQKTEGRE
VEEPFSAGQKGSSAMPHKRNPVICERISGLSRVIRANVNVGLQDVALWHE
RDISHSSAERVVLPDSTIALEYILDKMLFVIKNLHVYPDAIERTLGVTRG
LVFSQKVLLALIEKGKIIREEAYLIVQEHAMAVWASQSETLKSRLEKDDR
VSKVLTQKDLDDIFKIEPYLEKVGLIYKRLGLE
>LA3513 purC, Phosphoribosylaminoimidazole-succinocarboxamidesynthase
MNPSYKGKVRDIYDLGDKLILSSSDRISAFDVVFPQLVPDKGKVLNRISV
SWFEFFKDVPNHILETDVKYFPIPFQNHPDLEGRSVLVKKCKRIDYECVV
RGYISGSGWKEYKNDGTLAGIKLPSGFKESQKLPEPVFTPAVKNDQGHDE
NISEKEMENRIGKELFNILKEKSISIFLRASEVVDKAGIILCDTKFEFGI
LDGQVILIDELLTPDSSRYWSTDTYSVGISPPSLDKQILRNYLETTSWNK
MPPAPNLPAELIQELREKYQKIEDLILSCTSQKSK
>LA3764 purD, Phosphoribosylamine--glycine ligase
MQVKLKVLLIGSGGRESAIAFYLRKSVLLSELKVFPGNGGFPDQELLPPD
SFQVLDKNSVQSFLKQNPFDLIVVGPEDPLVAGFADWAAELNIPVFGPDS
FCAQVEGSKDFAKSLMTEAKIPTAEYKTFSEYSDSLKYLESKSIPIVIKA
DGLAAGKGVTVATSKEMAQTALKEIFKDKKFGSSGNQVVIEEFMEGQEAS
IFAISDGDSYFLLPAAQDHKRAFDGDQGPNTGGMGAYCPAPVISESILQK
VKEQIFDPMFDLFRKKGHPYRGLLYAGLMISPNGEPKVVEFNCRFGDPET
QCVLAMLDGDLLELLYRASTGKIKGVQAAVKKGAAVVVVLAAQGYPDFYE
KNIPLNLPETSGQNVHLFHAGTLKKDGKVFSSGGRILGIVAQGADLKSSV
DQAYSFLEKIQAPKTFYRKDIGYRAL
>LA1463 purE, Phosphoribosylaminoimidazole carboxylase catalytic subunit
MNTKVAIIMGSHSDWETMKEAEIILKEFGVSIHKEIVSAHRSPELMLEFS
KSAKEKGYSVIIAGAGGAAHLPGMVASMTTLPVLGVPIQSKTLNGLDSLL
SIVQMPGGVPVGTLAIGTAGAKNAGLLAVRILALQDPILSEKLERYRNQI
REDALSKNKDLL
>LA4092 purF, Amidophosphoribosyltransferase
MSRIPDKSRIRRQAQDDKPKEECAIFGIFNSSEASNFTYLGLYSMQHRGQ
ESSGIVSSDGEHLYRYAGMGLVAHIFTETKLKELQGNAAIGHNRYSTTGA
SFLRNAQPLRVESHLGAVSLAHNGNLVNSWELRSQLEKEGSIFQTTIDSE
VIVHLMARSGETDFLSALSSALKKVRGAYSLVILTKTQLIAVRDPNGFRP
LVMGRREDGSIVFASETCAFDITDTKYERDVEPGEMIVVDKNGMNSYYPF
PKASPSLCIFEYIYFARPDSSIFGESVYKVRKNLGRFLARELPVPADVVI
PVPDSANIAALGYAEESGISYQSGLIRSHYIGRTFIEPDQKIRDFGAKIK
YNVVRNVVEGKRVIVVDDSIMRGTTSRKIIKMIRNAGAKEIHLRVSAPPT
ISPCYYGIDIPTHNELIAATHTIEEIRKYLRVDSIAYLSVESMNRAVMDH
KGGGFCNACFTAQYPVEFQSELGNQKSLFKEYQVEERVVY
>LA2283 purH, IMP cyclohydrolase
MIQIKRALISVSDKSGLVEFAKFLNQNGVEIISTGGTLKLLKDNGIAAIA
IDDYTGFPEILDGRVKTLHPKVHGGLLGVISNPAHKQKMEELKIPKIDLV
VVNLYPFLKTVSKPEVQLEEAIENIDIGGPSMIRSAAKNYKHTLVLTDPN
DYKKIQNLISSSGISEEISASYMRKAFSHTAMYDAAISSWFYKQSGEVFP
DVLNLSFIKKQKLRYGENPHQAASFYEPLFTKSDFSPLQGKELSFNNMLD
FDAAFHISSLLPENTVCIIKHLNPCGIAYADNPLEAFQLARRTDPISAFG
GVIGIKGQVNGELATSITENFVEGVIAQKFTQEALEVFSKKPNIRLIEIQ
DFKEALDELDLRPIHHGLLIQDRDYTTITEKDLKVVTKKQPSPDDIRGLM
FAWSCVRFIKSNAIVYTEENATLGIGAGQMSRVDSVQLGANKALNVGLSV
VGSYVASDAFFPFRDGIDALAKAGAKAIIQPGGSVRDEEVIQAADEHGLI
MVFTGMRHFRH
>LA1462 purK, Phosphoribosylaminoimidazole carboxylase ATPase subunit
MNNSRMLLPGSRLGVMGSGQLARMFCLEAIPFGYEISVYSPEKNSPAAGA
GAKEYISTYEDEKALTFFLENIDGLTFEFENIPEIALTTIENFSKRTGLI
VRPSPNCVRISQNRWKEKTSFQKAGIPTVKFYPVLTEEDKKSVLSKTNFP
CILKTNTMGYDGRGQIRCITEQELSLVFSNLNKPDHIVEEFFQFTSEASV
IMARFEDGKILNFRPSKNVHKNHILDLTFYPGNFPDSIETKLVNYAKKLA
ETIDYVGVFGIEFFIRGDEILCNEFAPRPHNSGHFSQNSGTISQFSLQLR
TLCNLPSPKTILANPVSMKNILGEDYKPGSTLWNKTLENPYYHLHLYGKT
EIRNGRKMGHWNYSGPNIESAFLNWD
>LA1323 purL, Phosphoribosylformylglycinamidine synthase II
MEKDVVSLEDALEHGLTKEEFQKIQEILGRIPNSTELGIFSAMWSEHCSY
KNSILKLKTLPTTSDKLLAKAGEENAGAMDIGDGLAVVFKIESHNHPTAV
EPYQGAATGVGGIMRDIFTMGARPIVSLNSLRFGNPDEPKNKYLLSRAVK
GIGDYGNSLGIAVSGGELFIDECFSKNPLVNAMTVGIVRHDQMASATTGG
QIGNSVYIVGATTGRDGIHGASFASKDLSKESESKRSAVQVGDPFMEKLL
MEASLEAIQKGLLVGIQDMGAAGISCATSEMSAKGKTGMKIDLDLVPFRE
TGMNAYEAMLSESQERMLVVPKKGKESELVSIFEKWNLNAVKIGEVTADG
MIEIYMGGKLKAKIPAESLVLGGGAPRYERETKRPSYLDAVKTWKPDEIP
DVTKGANSKEILLKILSSWNVCSRKPITEQYDSEVGLVKLIGPGLDGGLS
AIPGTNKALATATDCNSRYTYLDPYKGAEFAVCEAARNVYVTGATPYGVT
NNLNFANPYIPENYYIFSECIRGMGDACRFLGLPVTGGNVSFYNESPEGP
IFPTPTIGMVGILENKEKLIFNFPKEIGVELAVLGNFRPSLGGSEYLKKI
HGQINGSIPELDIKEELELCKLILSLNESRILKSAKDLSLGGIAVALSKT
VLFSGLGIESDLTSLRRNRLDLTLFGESSTAVLVGFDSLSKEDIRKQTEA
YGLKFYPIGKTNSSGILEIKDAEIKISFQELSGPYEKGLEAVFAL
>LA2935 purM, Phosphoribosylformylglycinamidine cyclo-ligase
MPDFQVSPVFFCVQGISIFSIYSKKESGLIGMEEKITYKNAGVDTEKGRE
FIQKIKRNVESTHGPRVIGGLGGFAGAYDVSVLKKYKHPILLSGTDGVGT
KIELARLLKIYNTIGIDLVAMCVNDILVCGGEPLFFLDYIACGKLDPEKM
DQIVSGIVQGCKMSNASLLGGETAEHPGTMKEDEFDLAGFVVGAVEKDSM
IDGSTIRSGDKILGLESSGPHSNGFSLIRKLLLKEGKYLPTDPQQVKFLK
DYALKPTRIYVSSILKLLQQVSVKGMVHITGGGYQENVPRILPQGTQSKF
FKEKIPSGYFFEKIKKDHKIEELELFATFNMGIGYMVIVSEENAELAKKI
MESSGEVVHEIGEIVSGNKEEVQFV
>LA2282 purN, Phosphoribosylglycinamide formyltransferase
MATLFTKPKKKIVFLASGRGSNLRAVLQNIKVGKIRGIAQTLICDHPDAK
ALEVAQEFELTSQVLNFSSFSNKSEYHTKLLQLLLEIKPDLIVTAGYMRI
LKSPIIQTFSNRIINIHPSLLPAFPGLNAQKQALEYGVKIAGCTAHFVDE
GIDSGPIILQGVVKIEEGMTERDLTLEILKEEHKILPLAVQYFCEDRLTI
QNRKVKIG
>LA3511 purQ, phosphoribosylformyl glycinamidine synthetase
MKIAVITFPGSNCDSDIYRVLKDQYNAEVDRIWHRDGLDKKYELVILPGG
FSYGDYLRSGAMAGFSPVMKSVKEHVDKGGKLFGICNGFQILTEAEYLPG
ALIRNKTLKYICKTVILTKGSAGNPVTASMDVRKELKIPIAHADGCYYAT
SDVLKQLEDEDRILFRYSGENPNGSLDSIAGITSKNFKIVGMMPHPERAM
NPITGEMDGKVVLDLILGS
>LA4266 purT, Phosphoribosylglycinamide formyltransferase 2
MKKKILLLGSGELGKEFVIAAQRLGQYVIAVDSYDDAPAMQVAHEKEIIN
MLDGNLLDQIIAKHKPDLIVPEIEAIKTERFYEYEKQGYQVVPSAKAANF
TMNRKSIRDLAAKDLKLLTAKYAYASSIDELIKATEILGFPCVVKPLMSS
SGKGQSVIQSREEISKAWEASQTKGRAGAAEIIVEEFIPFESEITLLTVT
QKNGKTLFCPPIGHRQERGDYQESWQPAAISEVQLKEAQRMADAVTKELT
GFGIWGVEFFLTEDKVYFSELSPRPHDTGMVTLAGTQNFNEFELHLRAIL
GIPILEITLERKGASAVILASTENKTPEISGLDIASGMSESDFRIFGKPI
TRPYRRMGVTLSYSTKGEEISSLRKRAVLLASKIKVD
>LA0778 pyrB, Aspartate carbamoyltransferase
MSKGSFFTFCRLMYYNHKNVLDTEQFSKPDLDFLIGKIRVMERLVEQNKA
FGILTGKLLASLFFEASTRTRLSFEAAMERLGGRVISTVGFQFSSISKGE
TLYDTMKMVEAYADIAVIRHPVEGSSRIAAGAVKIPVINAGDGAGQHPTQ
AILDLYTIISEKGTLDGLTVAFIGDLKYGRTIHSLINLLRHYKVRLFLIS
PPELALPESYKKALQGYSLTLEETTDIKAVWDCDVAYVTRIQEERFPDHK
EYERLKDLFKINKELILASKKETTVLHPLPRVNELSTDVDDLPNAAYFRQ
ARYGVVSRMTLLCLSLGQDF
>LA3636 pyrC, Dihydroorotase
MIKKISGRIVTHEKDFLGTVEWDSKTGLILTVLEQKESIPILNSQHQENE
IQFNSLETVIFPGFGDIHIHAREDESGKHTYKEDFVSASAAAVNGGVIHV
ADMPNNPIPPIDENSYSKKRKLADRSNIHITLYAGIGPDTKPLKKSVPYK
VFMGPSIGELFFHNNQTLEDTISSYVGENVSFHCEDPEILEKHQNETFHE
DRRPAEAETTATDFALYLIEKYNLRGKLCHYSTGEGLNKIKFAKQKGVKV
TCEVTPTHLFFDRSMLTPENRHWFQMNPPLRSKEDRERMLEGVKQGWIDY
LATDHAPHSIEEKRKGTSGISQLDTYSLFVTWLVLKAGVELKTVARICAK
NPGDFVNEYLPEKFGKGFGRIEPGYSANFTVLNLKKPKKFLKEEIKSKSG
WSPFENFEFPGSIEAVFFLGKQMK
>LA4290 pyrD, Dihydroorotate dehydrogenase
MINRNKIVLEMFLPHLRQSAYSVFLKPFFLSLDPETAHELAKNFLGIGQK
FPGFLTLMESMTSYQSDRLKTKIAGIEFENPLGMGAGFDKTGELYPFLSR
MGFGHIEVGTITGQKQSGNPKPRVFRYPQDQALVNRMGFNNPGADSAEKI
ISSQKKTKIRGINAGKTKIVPEEKAVEDYVYTLKKLSPYADYAVINISSP
NTPGLRNFQKQENFVSLIQGIRKDLGKNFKIPLFVKFAPDMETKELEALL
ETSLSLKINGVVLTNTTIDKSCLKNYPNVEKEGGLSGTPLKNRSTEFVRI
AYRILKRRIPIIGVGGIDSEKTALEKILAGADLIQIYTGYIYQGPFLPMR
ILKFLDRFLEKQDLKTVSDLVGKEKEIRLDQK
>LA2988 pyrE, Orotate phosphoribosyltransferase 1
MLKKELSMKQELLELIRTHVYRYSEQPFTLASGRKSRHYFNCKEITLVPD
RLELLCKFIVEQHLGESGILLPHAFGGLTMGADPICYGISLEFRKQNKNV
YPLIVRKLSKDHGTKKLVEGSTHLVKQCVVIDDVITTGGSTIQAIRSLRD
CGIEVVQGVCILDRQEGGKDAILAEGVEMFPIFKKSDFGNLEHE
>LB310 pyrF, orotidine-5'-monophosphate decarboxylase
MGGKMNFQSKFLTRSQSLKSLLCVGLDPDFDKLPEIVKRSPEPLVQFCKE
IIDATASYAVAYKPNIAFFEVFGSSGIRQFEKVIGHLKSNYPQIPIVADV
KRGDLDNTARQYAKYYFGDLQVDSLTLSPYMGLDSIRPFLEYQDYLIFWL
CLTSNPDSAQFQKKRFSETGRTLYEEVVYVANLVAISNLGFVVGATSPSE
LETLRTQNPNRIFLIPGFGAQGAKLENLLPVCGRNSLINSSRGIHFASNG
SDFAVRAGQEAEKIHKMMQTHFIGL
>LA2409 pyrG, CTP synthase
MEYTLSRTKFIFVTGGVSSSLGKGVTVAALGCLLESRGYTVSLQKMDPYI
NIDPGTMSPYQHGEVYVTADGAETDLDLGYYERFTHSKLTRKNSVSTGQI
YNTVIQRERKGDYLGRTVQVVPHITNEIRNRMYIVAREENPDFIIVEIGG
TVGDIESIPFLEAIRQMRYEHGSSNVLFVHLTLVPTITAAGEAKTKPTQH
SVKELLGLGIQPDILVCRVSQPMTKEMKNKLSLFCNVKEENVISASDIST
SIYEIPKMYKEEKLDEVVLKTMGMELRESNFSEWDKMVKGLLTTKQTVQI
AVVGKYISLQDAYRSIYESLSHGGIAHDTKVEFIKVDPENLNKDSYVEIL
KKVHGILVPGGFGDRGIEGKILAIQYARTNGIPFLGICLGMQCAVVEYGR
NVLGLKDANSTEIRPDTEHPVISLLEEQNDIEQMGGTMRLGSYPCKVKEN
TLSYSEYKSILIHERHRHRFEFTNRYRKQYEENGMIIAGTSPDDNLVEIV
EIPKHNWFIGVQFHPEFQSKPTLPHPLFAGFIRASVKYSKKG
>LA3296 pyrH, uridylate kinase
MATEAKYNRILIKLSGEALAGEGEFGIDTNKAHSLAEEIKEVHDLGVEIA
LVVGGGNIIRGTNLAKAGIDRATADYMGMLATIQNALALQDACEKKGLYT
RVQSAIEINSIAESYIRRRAVRHLEKRRIVIFAGGTGNPYFTTDTTASLR
AVEVGCDVILKATKVDGVYTADPKKDNGAKRYSQISFMESINRRLKVMDS
TALSLCMENNMSIIVFDIFKRGNLKDLVTGKNIGTLISNSEDIQIDGK