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# Streptococcus pyogenes phage 6180.4

>M28_Spy0658 5'-nucleotidase
MIYNDYVNLLGDFMKKYFILKSSVLSILTSFTLLVTDVQADQVDVQFLGV
NDFHGALDNTGTAYTPSGKIPNAGTAAQLGAYMDDAEIDFKQANQDGTSI
RVQAGDMVGASPANSALLQDEPTVKVFNKMKFEYGTLGNHEFDEGLDEFN
RIMTGQAPDPESTINDITKQYEHEASHQTIVIANVIDKKTNDIPYGWKPY
AIKDIAINDKIVKIGFIGVATTEIPNLVLKQNYEHYQFLDAAETIAKYAK
ELQEQHVHAIVVLAHIPATSKDGVVDHEMATVMEKVNQIYPEHSIDIIFA
GHNHQYTNGTIGKTRIVQALSQGKAYADVRGTLDTDTNDFMTTPSANVIA
VAPGIKTENSDIKAIINHANDIVKTVTERKIGTATNSSTISKTENIDKES
PVGNLVTTAQLTIAKKTFPTVDFAMTNNGGIRSDLVVKNDRTITWGAAQA
VQPFGNILQVIQMTGQHIYDVLNQQYDENQTYFLQMSGLTYTYTDNDPKN
SDTPFKIVKVYKDNGEEINLTTTYTVVVNDFLYGGGDGFSAFKKAKLIGA
INTDTEAFITYITNLEASGKTVNATIKGVKNYVTSNLESSTKVNSAGKHS
IISKVFRNRDGNIVSSEIISDLLTSTENTNNSLGKKETTTNKNTISSSTL
PITGDNYKMSPIMTILALISLGGLNAFIKKRKS
>M28_Spy1676 NrdI.1
MPQITLVFISLSGNTLSFVKRLSLYLADNYDYHVKQINIKDLKHETFPVK
EEFVAILPTYLEGGNGVDSGEVEILTTPLGEFIAAHGNAQRCLGIIGSGN
KNFNHQYCLTAKQYAKRFGFPLLGDFELRGTPDDISRLAQVIMEASSRHS
SNDTQTLPNS
>M28_Spy1837 hypothetical membrane associated protein
MKNISRKCFMTSVVCIVLGAILLGAGYATGGLQDIKHQTAPKKVIQTFDH
VTALDIDTNFSTITVETGPVKKPTVTYYTHSKFIDPLEIKIENETLHISE
KPRDVIITGGIELIGFGLNKSDRNHNYRTTTITLPKGTSLKELKGSSMPQ
ATISDLTVQDLEFSGGLTLLNTRIKKGKVFGTFNATDSLLANLELKADYS
LSSLTNSSLENGTISLGHGQLTTKNTNLKSVTIQSLSPGGVETEETSLEN
VTFTVTSEQENEETNDNGAIFTAHALTLKGTNTISGGNVAVDITLTDPKT
TAYKTKTEDGKILLGSQLTPAKIGKESTSDVISYVAENKAATGNLTVNLN
KGDITIK
>M28_Spy0193 deoxyuridine 5'-triphosphate nucleotidohydrolase
MTKIRGFELVSSFTNPDLLPKRETTHAAGYDLSVAEAVTIAPGEIKLVPT
GVKAYMQDGEVLYLYDRSSNPRKKGIILINSVGVIDADYYGNEANEGHIF
AQMQNITDHPVTLAVGERIVQGVFMPFLIADGDQARGERTGGFGSTGQ
>M28_Spy1078 phosphorylase, Pnp/Udp family
MDWLIGYGVKEMISTGTCGVLVPIAENRFLVPVKALRDEGTSYHYVAPSC
YIDIDPKMLRPIEKTLSAQGLAYQEVITWSTDGFYRETKEKVAYRQEEGC
SVVEMGCSALAAVAQLRGILWGQLLFTADTLADVEVYDQRNRGADSFSFA
LHLCLEVFNTLEKDGKATDF
>M28_Spy0078 bis(5'-nucleosyl)-tetraphosphatase(asymmetrical)
MTECIFCHQLKANQLLTQSQYFKVVFDIDPIQKGHLLLISKDHYTSLTQL
PKEVRYDLIDLQAALVAKLEQHLPISGVTSVSNDKELMDEGTHFHLHLIP
RLTNDSFWESITINQENWDLTPFLKHL
>M28_Spy0293 xanthosine triphosphate pyrophosphatase
MAETKNKCGACHLMSEKIYEYKDENNWFIGKMTGHNLISGWGVKHTTIKK
IDDLLDGIAATLDWENPKGYDVSVVRYQSPLSLITFIIDMINQETQRKIK
VTPHAGTILLMENAKLLAVYLPEGGVSTATFFATSEQGFGDIILIATRNE
GKTKEFRNLFGQLGYRVENLNDYPELPEVAETGTTFEENARLKAETISRL
TGKMVLADDSGLKVDALGGLPGVWSARFSGPDATDAKNNAKLLHELAMVF
DQKKRSAQFHTTLVVAAPNKDSLVVEAEWPGYIATQPKGENGFGYDPVFI
VGETGRHAAELEADQKNQLSHRGQAVRKLMEVFPAWQAKQS
>M28_Spy0101 deoxyadenosine kinase
MKPSSKQYANDIRRRRMLIVLAGTIGAGKSSLAAALGEHLGTDVFYEAVD
NNPVLDLYYQDPKKYAFLLQIYFLNKRFKSIKEAYQADNNILDRSIFEDE
LFLKLNYKNGNVTKTELDIYQELLANMLEELEGMPKKRPDLLIYIDVSFD
KMLERIEKRGRSFEQVDGNPSLEQYYHQVHGEYPTWYEDYKVSPKMKIDG
NSLDFVQNPQDLATVLKMIDTKLKELHLL
>M28_Spy0833 xanthine permease
MTHSTKQEHSHSQSAVLGLQHVLSMYAGSILVPIMIAGALGYSARELTYL
ISTDIFMCGVATFLQLKLTKHTGVGLPVVLGCAFQSVAPLSIIGAQQGSG
AMFGALIASGIYVILVAGIFSKIARFFPPIVTGSVITVIGLSLVGVAMGN
MGDNVKEPTAQSMMLSLLTIVIILLVQKFTKGFVKSISILIGLVVGTLVS
AMMGLVDTTPVVEASWIHVLTPFYFGMPTFEITSIVMMCIIATVSMVEST
GVYLALSDLTNDQLDEKRLRNGYRSEGIAVFLGGLFNTFPYTGFSQNVGL
VQISGIKTRRPIYYAAGILVVIGLLPKFGAMAQMIPSPVLGGAMLVLFGM
VALQGMQMLNRVDFQKNEYNFIIAAVSISAGLGFNGTNLFASLPETAQMF
LTNGIVIATLTSVVLNLVLNGKDKQDE
>M28_Spy0177 tRNA-specific adenosine deaminase
MELGESFLMPYSLEEQTYFMQEALKEAEKSLQKAEIPIGCVIVKDGEIIG
RGHNAREESNQAIMHAEMMAINEANAHEGNWRLLDTTLFVTIEPCVMCSG
AIGLARIPHVIYGASNQKFGGADSLYQILTDERLNHRVQVERGLLAADCA
NIMQTFFRQGRERKKIAKHLIKEQSDPFD
>M28_Spy0821 ribose-phosphate pyrophosphokinase
MTERYADKQIKLFSLTSNLPIAEKIAKAAGIPLGKMSSRQFSDGEIMINI
EETVRGDDIYIIQSTSFPVNDNLWELLIMIDACKRASANTVNIVLPYFGY
SRQDRVAKPREPITAKLVANMLTKAGIDRVVTLDLHAVQVQGFFDIPVDN
LFTVPLFAERYSKLGLSGSDVVVVSPKNSGIKRARSLAEYLDSPIAIIDY
AQDDSEREQGYIIGDVSGKKAILIDDILNTGKTFAEAAKILERSGATDTY
AVASHGLFAGGAAEVLETAPIKEIIVTDSVKTKNRVPENVTYLSASDLIA
EAIIRIHERRPLSPLFSYQPKGKNNA
>M28_Spy0650 nucleoside diphosphate kinase
MIKLYGFKYGLVGEVLRRIERLGFTFERLELRQASSKYLAKHDEALVINL
FILDLKLT
>M28_Spy0064 adk, adenylate kinase
MNLLIIGLPGAGKGTQAAKIVEEFGVAHISTGDMFRAAMANQTEMGRLAK
SYIDKGELVPDEVTNGIVKERLAEDDIAEKGFLLDGYPRTIEQAHALDAT
LEELGLRLDGVINIKVDPSCLVERLSGRIINRKTGETFHKVFNPPVDYKE
EDYYQREDDKPETVKRRLDVNMAQGEPILEHYRKLGLVTDIEGNQEITDV
FADVEKALLELK
>M28_Spy0708 apt, adenine phosphoribosyltransferase
MDLTNYIASIKDYPKAGITFRDISPLMADGKAYSYAIREIAQYACDKDID
MVVGPEARGFIIGCPVAVELGIGFAPVRKPGKLPRDVVSADYEKEYGLDT
LTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGIVAGCAFLIEL
EGLNGRHAIRNYDYKVLMQFPG
>M28_Spy0622 carA, carbamoyl-phosphate synthase small chain
MTKRLLILEDGTIFEGEPFGADIDVTGEIVFNTGMTGYQESITDQSYNGQ
ILTFTYPLIGNYGINRDDYESISPTCKGVVVSEVSRLASNWRKQMTLDAF
LKIKGIPGISGIDTRALTKIIRQHGTMKATMADDGDSIQHLKDQLRATVL
PTNTIEQVSTKTAYPAPGIGKNIVLVDFGLKHSILREFSKRQCNITVVPF
NITAEEVLQLNPDGLMLSNGPGNPEDLPEALDMIRGVQGKIPIFGICMGH
QLFSLANGAKTCKMTFGHRGFNHAVREIATGRIDFTSQNHGYAVERSSLP
DTLMVTHEDINDKTVEGVKHRDFPAFSVQFHPDAAPGPHDASYLFDEFLE
MIDSWRCTSK
>M28_Spy0624 carB, carbamoyl-phosphate synthase large chain
MLTLPLLVVFLVSLIMPKRKDIQKIMVIGSGPIIIGQAAEFDYAGTQACL
ALKEEGYKVILVNSNPATIMTDKEIADKVYIEPLTLEFVNRIIRKERPDA
ILPTLGGQTGLNMAMALSKAGILDDLEIELLGTKLSAIDQAEDRDLFKQL
MQELDQPIPESTIVKTVDEAVTFARDIGYPVIVRPAFTLGGTGGGICSSE
EELCEITENGLKLSPVTQCLIERSIAGFKEIEYEVMRDSADNALVVCNME
NFDPVGIHTGDSIVFAPTQTLSDIENQMLRDASLKIIRALKIEGGCNVQL
ALDPYSFKYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMI
NPITGTTYAMFEPTLDYVVAKIPRFPFDKFEHGERQLGTQMKATGEVMAI
GRNLEESLLKACRSLEIGVCHNEMTSLSNISDEELVTKVIKAQDDRLFYL
SEAIRRGYSIEELESLTKIDLFFLDKLLHIVEIEQDLQMHVEHLESLKKA
KRYGFSDQKIAEIWQKDESDIRAMRHSHSLYPVYKMVDTCAAEFDAKTPY
FYSTYELENESVQSNKESILVLGSGPIRIGQGVEFDYATVHSVKAIQKAG
YEAIIMNSNPETVSTDFSVSDKLYFEPLTFEDVMNVIDLEQPKGVIVQFG
GQTAINLAQALSEAGVTILGTQVEDLDRAEDRDLFEKALKELGIPQPQGQ
TATNEEEALEAAKKIGFPVLVRPSYVLGGRAMEIVENKEDLREYIRTAVK
ASPEHPILVDSYIFGKECEVDAISDGKSVLIPGIMEHIERAGVHSGDSMA
VYPPQQLSKQIQETIAEYTKRLAIGLNCIGMMNVQFVIKNEQVYVIEVNP
RASRTVPFLSKVTGIPMAQIATKLILGQTLKDLGYEDGLYPQSQLVHIKA
PVFSFTKLAQVDSLLGPEMKSTGEVMGSDTSLEKALYKAFEANNSHLSEF
GQIVFTIADDSKAEALSLARRFKAIGYQIMATQGTAAYFAEQGLSACLVG
KIGDAANDIPTLVRHGHVQAIVNTVGIKRTADKDGQMIRSSAIEQGVPLF
TALDTAKAMLTVLESRCFNIEAI
>M28_Spy0915 cdd, cytidine deaminase
MGTTDLVSCAVQASEYAYVPYSHFPVGAALKTKDGTIYTGCNIENVSFGL
TNCGERTAIFKAISDGHKELVEIAIYGETMQPVSPCGACRQVMAEFFAPS
SLVTLIAKNGQTVEMTVGDLLPYSFTDLI
>M28_Spy0597 cmk, cytidylate kinase
MKAIKIAIDGPASSGKSTVAKIIAKNLGYTYLDTGAMYRSATYIALTHGY
TGKEVALILEELEKNPISFKKAKDGSQLVFLGDEDVTLAIRQNDVTNNVS
WVSALPEIREELVHQQRRIAQAGGIIMDGRDIGTVVLPDAELKIFLVASV
EERAERRYKENLEKGIESDFETLKEEIAARDYKDSHRKVSPLKAAEDALI
FDTTGVSIDGVVQFIQEKAEKIVDMS
>M28_Spy1535 comEB, ComE operon protein 2
MTNRLSWQDYFMANAELISKRSTCDRAFVGAVLVKDNRIIATGYNGGVSA
TDNCNEAGHYMEDGHCIRTVHAEMNALIQCAKEGISTDGTEIYVTHFPCI
NCTKALLQAGIKKITYKAHYRPHPFAIELMEKKGVAYVQHDVPHIILGGK
EGPNG
>M28_Spy1578 deoC, deoxyribose-phosphate aldolase
MEVKDILKTVDHTLLATTATWPEIQTILDDAMAYETASACIPASYVKKAA
EYVSGKLAICTVIGFPNGYSTTAAKVFECQDAIQNGADEIDMVINLTDVK
NGDFDTVEEEIRQIKAACQDHILKVIVETCQLTKEELIELCGVVTRSGAD
FIKTSTGFSTAGATFEDVEVMAKYVGEGVKIKAAGGISSLEDAKTFIALG
ASRLGTSRIIKIVKNEATKTDSY
>M28_Spy0679 deoD2, purine nucleoside phosphorylase
MRRQFPIFTLFFVAFNILIMSIHISAKKGDIADKILLPGDPLRAKFIAEN
FLEDAVCFNEVRNMFGYTGTYKGRRVSVMGTGMGMPSISIYARELIVDYG
VKTLIRVGTAGAIDPEVHVRELVLAQAAATNSNIIRNDFPEFDFPQIADF
GLLDKAYHIAREMGVTTHVGNVLSSDVFYTNMPERNMALGKLGVKAIEME
AAALYYLAAQHHVKALGIMTISDNLNDPTEDTTAEERQTTFTDMMKVALE
TLIAND
>M28_Spy0899 fhs.1, formate--tetrahydrofolate ligase
MKSDIEIAQSVALQPITDIVKKVGIDGDDIELYGKYKAKLSFEKMKAVEA
NEPGKLLLVTAINPTPAGEGKSTMSIGLADALNQMGKKTMLALREPSLGP
VMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLQQ
GNDLGIDPRRIIWKRVLDLNDRALRQVIVGLGSPVNGVPREDGFDITVAS
EIMAILCLATDLKDLKKRLADIVVAYTYDRKPVYVRDLKVEGALTLILKD
AIKPNLVQTIYGTPALIHGGPFANIAHGCNSVLATSTALRLADYTVTEAG
FGADLGAEKFLNIKVPNLPKAPDAIVIVATLRALKMHGGVAKSDLAAENC
EAVRLGFANLKRHVENMRQFKVPVVVAINEFVADTEAEIATLKALCEEIK
VPVELASVWANGAEGGLALAKTVVRVIDQEAADYKRLYSDEDTLEEKVIN
IVTQIYGGKAVQFGPKAKTQLKQFTEFGWDKLPVCMAKTQYSFSDNPSLL
GAPTDFDITIREFVPKTGAGFIVGLTGDVMTMPGLPKVPAAMAMDVAENG
TALGLF
>M28_Spy1758 fhs.2, formate--tetrahydrofolate ligase
MVLSDIEIANSVTMEPISKVANQLGIDEEALCLYGKYKAKIDARQLVALK
DKPDGKLILVTAISPTPAGEGKTTTSVGLVDALSAIGKKAVIALREPSLG
PVFGVKGGAAGGGHAQVVPMEDINLHFTGDFHAIGVANNLLAALIDNHIH
HGNSLGIDSRRITWKRVVDMNDRQLRHIVDGLQGKVNGVPREDGYDITVA
SEIMAILCLSENISDLKARLEKIIIGYNYQGEPVTAKDLKAGGALAALLK
DAIHPNLVQTLEHTPALIHGGPFANIAHGCNSVLATKLALKYGDYAVTEA
GFGADLGAEKFIDIKCRMSGLRPAAVVLVATIRALKMHGGVPKANLATEN
VQAVVDGLPNLDKHLANIQDVYGLPVVVAINKFPLDTDAELQAVYDACDK
RGVDVVISDVWANGGAGGRELAEKVVALAEQDNQFCFVYEEDDSIETKLT
KIVTKVYGGKGIRLTPAAKRELADLERLGFGNYPICMAKTQYSFSDDAKK
LGAPTDFTVTISNLKVSAGAGFIVALTGAIMTMPGLPKVPASETIDIDEE
GNITGLF
>M28_Spy1686 flaR, DNA topology modulation protein flar-related protein
MKIAIIGHSGSGKSTLARFLGQHYHCEVVHLDQLHFSSNWQERSDHDMIA
DLSTCLLKQDWIIEGNYANCLYEERMSEANHIIYVNFSRFHCVYRAFKRY
LNYRGKTRPDMADNCQEKFDVAFVKWILLDGRSRNQLKKYQSVIQKYPHK
TIVLTNQKQLNHYMNTIN
>M28_Spy1382 gmk, guanylate kinase
MSERGLLIVFSGPSGVGKGTVRQEIFSTPDHKFEYSVSMTTRPQRPGEVD
GVDYFFRTREEFEELIKTGQMLEYAEYVGNYYGTPLTYVNETLDKGIDVF
LEIEVQGALQVKSKVPDGVFVFLTPPDLDELEDRLVGRGTDSQEVIAQRI
ERAKEEIALMREYDYAVVNDEVALAAERVKRIIETEHFRVERVIGRYDKM
IKITKNPFKAK
>M28_Spy0891 guaA, glutamine-hydrolyzing GMP synthase
MTEISILNDVQKIIVLDYGSQYNQLIARRIREFGVFSELKSHKITAQELR
EINPIGIVLSGGPNSVYADNAFGIDPEIFELGIPILGICYGMQLITHKLG
GKVVPAGQAGNREYGQSTLHLRETSKLFSGTPQEQLVLMSHGDAVTEIPE
GFHLVGDSNDCPYAAIENTEKNLYGIQFHPEVRHSVYGNDILKNFAISIC
GARGDWSMDNFIDMEIAKIRETVGDRKVLLGLSGGVDSSVVGVLLQKAIG
DQLTCIFVDHGLLRKDEGDQVMGMLGGKFGLNIIRVDASKRFLDLLADVE
DPEKKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDIIESGTETAQTI
KSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGIALGMPEEIVWRQPFPG
PGLAIRVMGAITEEKLETVRESDAILREEIAKAGLDRDVWQYFTVNTGVR
SVGVMGDGRTYDYTIAIRAITSIDGMTADFAQLPWDVLKKISTRIVNEVD
HVNRIVYDITSKPPATVEWE
>M28_Spy0831 guaC, GMP reductase
MLKEEKLMFNDIPVFDYEDIQLIPNKCIITSRSQADTSVTLGKYQFKLPV
IPANMQTIIDETIAERLAKEGYFYIMHRFDEDSRKPFIKRMHEQGLIASI
SVGVKACEYEFVTSLKEDAPEFITIDIAHGHANSVIDMIKHIKTELPETF
VIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKVKTGFGTGGWQLAA
LRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMVMIGSLFAGHIESPGK
TVEVDGETFKEYYGSASEYQKGEHKNVEGKKILLPTKGHLSDTLTEMQQD
LQSSISYAGGKDLDSLRHVDYVIVKNSIWNGDSI
>M28_Spy1461 hit, bis(5'-nucleosyl)-tetraphosphatase(asymmetrical)
MENCIFCSIIQGDIPSSKVYEDEQVLAFLDISQTTKGHTLVIPKQHVRNL
LEMTAETASHLFARIPKIARAIQLATGATAMNIINNNEALAGQTVFHAHV
HLVPRYNEKDGISIQYTTHEPNFPVLEKLARQINQEVSS
>M28_Spy0012 hpt, hypoxanthine-guanine phosphoribosyltransferase
MLEQDIQKILYSENDIIRKTKKLGEQLTKDYQEKNPLMIGVLKGSVPFMA
ELMKHIDTHVEIDFMVVSSYHGGTSSSGEVKILKDVDTNIEGRDIIIVED
IIDTGRTLKYLRDMFKYRKANTIKIATLFDKPEGRVVKIEADYVCYNIPN
EFIVGFGLDYAENYRNLPYVGVLKEEVYSK
>M28_Spy1777 nrdD, anaerobic ribonucleoside-triphosphate reductase
MVSLEEDKVTVQPDIKVIKRDGRLVNFDSTKIYSALLKASMKVTRMSPLV
EAKLEAISDRIIAEIIERFPTNIKIYEIQNIVEHKLLAANEYAIAKEYIN
YRTQRDFARSQATDINFSIDKLINKDQTVVNENANKDSDVFNTQRDLTAG
IVGKSIGLKMLPSHVANAHQKGDIHYHDLDYSPYTPMTNCCLIDFKGMLA
NGFKIGNAEVESPKSIQTATAQISQIIANVASSQYGGCTADRIDEFLAPY
AELNFKKHMADAKKWIVETKRESYAFEKTQKDIYDAMQSLEYEINTLFTS
NGQTPFTSLGFGLGTSWFEREIQKAILTIRINGLGSEHRTAIFPKLIFTV
KRGLNLEPDSPNYDIKTLALECATKRMYPDMLSYDKIIDLTGSFKSPMGC
RSFLQGWKDENGQDVTSGRMNLGVVTLNLPRIAMESNGDMDKFWELFNER
MLISKDALIYRVERVTEAKPANAPILYQYGAFGKRLEKTGNVNDLFKNRR
ATVSLGYIGLYEVASVFYGGQWEGNPDAKAFTLSIIKAMKQACEDWSDEY
GYHFSVYSTPSESLTDRFCRLDTEKFGIVTDITDKEYYTNSFHYDVRKSP
TPFEKLDFEKDYPEAGASGGFIHYCEYPVLQQNPKALEAVWDYAYDRVGY
LGTNTPIDKCYNCQFEGDFTPTERGFTCPNCGNNDPKTVDVVKRTCGYLG
NPQARPMVNGRHKEISARVKHMNGSTIKYPGL
>M28_Spy0336 nrdE.1, ribonucleoside-diphosphate reductase alpha chain
MSQTNASYLSLNALTRFKKPDGSYHFDSDKEAVRRYLEEHVSPNQMAFNS
LEDKLAYLINEGYYEQAIFDAYPNDLIKEAFHYAYQQGYRFLNLMGAMKF
YQSYALKTLDGKQYLETFEDRAVMNALFLADGDQTFVFDVIDAILHRRFQ
PATPTFLNAGKKRRGEYISCYLLRVEDNMESISRAISTSLQLSKRGGGVA
LCLTNLREIGAPIKGIENQATGIVPVMKLLEDSFSYANQLGQRQGAGAVY
LHAHHPEVLTFLDTKRENADEKIRIKSLALGLVIPDITFQLAKENKDMAL
FSPYDIKRAYGKDMSDISITEEYDKLLANPAIKKTYISARKFFQLIAELH
FESGYPYLLFDDTVNKRNPHAKKGRIVMSNLCSEIAQVSTPSTFKEDLSF
ETIGEDICCNLGSINIAQAMADAPHFEQLITTSIRALDRVSRVSDLNCAP
SVETGNAANHAVGLGAMNLHGFLATNHIYYDTKEAVDFTDLFFHAMAYYA
FKASCQLAKEKGAFAGFSLSTYADGTYFAKYLQEDAKPQTAKVATLLQDY
GFTLPTVADWQALVADIKQFGLANAHLLAVAPTGSISYLSSCTPSLQPVV
APVEVRKEGSLGRIYVPAYQIDQANYAYYERGAYEVGPKAIIDVVAAAQK
HVDQAISLTLFMTDQATTRDLNRSYIQAFKQNCASIYYVRVRQDVLAGSE
QYDEDSLVTAPGASDETTTECQSCMI
>M28_Spy1116 nrdE.2, ribonucleoside-diphosphate reductase alpha chain
MSLKDIGDISYFRLNNEINRPVNGKIPLHKDKEALKAFFAENVLPNTMSF
TSITEKIEYLISNDYIESAFIQKYRPEFITELDSIIKSENFRFKSFMAAY
KFYQQYALKTNDGEHYLENLEDRVLFNALYFADGQEDLAKDLAVEMINQR
YQPATPSFLNAGRSRRGELVSCFLIQVTDDMNSIGRSINSALQLSRIGGG
VGITLSNLREAGAPIKGYAGAASGVVPVMKLFEDSFSYSNQLGQRQGAGV
VYLNVFHPDIIAFLSTKKENADEKVRVKTLSLGITVPDKFYELARKNEDM
YLFSPYNVEKEYGIPFNYLDITNMYDELVANPKITKTKIKARDLETEISK
LQQESGYPYIINIDTANKANPIDGKIIMSNLCSEILQVQTPSLINDAQEF
VEMGTDISCNLGSTNILNMMTSPDFGRSIKTMTRALTFVTDSSSIEAVPT
IKHGNSQAHTFGLGAMGLHSYLAQHHIEYGSPESIEFTDIYFMLLNYWTL
VESNNIARERQTTFVGFENSKYANGSYFDKYVTGHFVPKSDLVKSLFKDH
FIPQASDWEALRDAVQKDGLYHQNRLAVAPNGSISYINDCSASIHPITQR
IEERQEKKIGKIYYPANGLSTDTIPYYTSAYDMDMRKVIDVYAAATEHVD
QGLSLTLFLRSELPMELYEWKTQSKQTTRDLSILRNYAFNKGIKSIYYIR
TFTDDGEEVGANQCESCVI
>M28_Spy0334 nrdF.1, ribonucleoside-diphosphate reductase beta chain
MTQHYYERSQSPIEYALSETQKQLRSINWNYLNDDKDLEVWNRVTQNFWL
PEKVPVSNDLNSWRSLGEDWQQLITRTYTGLTLLDTVQATVGDVAQIQHS
QTDHEQVIYTNFAFMVGIHARSYGTIFSTLCSSEQIEEAHEWVVSTQSLQ
DRSRVLIPYYTGDDPLKSKVAAAMMPGFLLYGGFYLPFYLSARGKMPNTS
DIIRLILRDKVIHNYYSGYKYQQKVARLSPEKQAEMKAFVFDLLYELIDL
EKAYLRELYAGFDLAEDAIRFSLYNAGKFLQNLGYDSPFTDEETRISPEV
FAQLSARADENHDFFSGNGSSYVMGITEETTDDDWEF
>M28_Spy1118 nrdF.2, ribonucleoside-diphosphate reductase beta chain
MTTYYEAINWNEIEDVIDKSTWEKLTEQFWLDTRIPLSNDLDDWRKLSLQ
EKDLVGKVFGGLTLLDTMQSETGVEAIRADVRTPHEEAVLNNIQFMESVH
AKSYSSIFSTLNTKKEIEEIFEWTNNNEFLQEKARIINNIYANGDALQKK
VASTYLETFLFYSGFFTPLYYLGNNKLANVAEIIKLIIRDESVHGTYIGY
KFQLGFNELPEDEQENFRDWMYDLLYQLYENEEKYTKTLYDGVGWTEEVM
TFLRYNANKALMNLGQDPLFPDTANDVNPIVMNGISTGTSNHDFFSQVGN
GYLLGSVEAMSDDDYNYGL
>M28_Spy0335 nrdI, hypothetical protein
MAELIIVYFSSKSNNTHRFVQKLGLPAQRIPVDNRPLEVSTHYLLIVPTY
AAGGSDAKGAVPKQVIRFLNNPNNRKHCKGVISSGNTNFGDTFALAGPII
SQKLQVPLLHQFELLGTATDVKKVQAIFARLKHHTHDKQKQINNLITERT
HPCHKPMRHTSH
>M28_Spy1579 nupC, nucleoside permease
MEVIMQFIYSIIGILLVLGIVYAISFNRKSVSLSLIGKALIVQFIIALIL
VRIPLGQQIVSVVSTGVTSVINCGQAGLNFVFGSLADSGAKTGFIFAIQT
LGNIVFLSALVSLLYYVGILGFVVKWIGKGVGKIMKSSEVESFVAVANMF
LGQTDSPILVSKYLGRMTDSEIMVVLVSGMGSMSVSILGGYIALGIPMEY
LLIASTMVPIGSILIAKILLPQTEPVQKIDDIKMDNKGNNANVIDAIAEG
ASTGAQMAFSIGASLIAFVGLVSLINMMLSGLGIRLEQIFSYVFAPFGFL
MGFDHKNILLEGNLLGSKLILNEFVSFQQLGHLIKSLDYRTALVATISLC
GFANLSSLGICVSGIAVLCPEKRSTLARLVFRAMIGGIAVSMLSAFIVGI
VTLF
>M28_Spy0354 pfs, 5'-methylthioadenosine nucleosidase
MKIGIIAAMEEELSLLLANLLDAQEHQVLSKTYYTGRFGKHELILVQSGV
GKVMSAMTVAILVEHFKAQAIINTGSAGAVASHLAIGDVVVADRLVYHDV
DATAFGYAYGQMAGQPLYYDCDPQFVAIFKQVLKHEKTNGQVGLIATGDS
FVAGQDKIDQIKTAFSDVLAVEMEGAAIAQAAHTAGKPFIVVRAMSDTAA
HDANITFDQFIIEAGKRSAQILMTFLENLPV
>M28_Spy0018 prsA, ribose-phosphate pyrophosphokinase
MEEKMSYSDLKLFALSSNKELAEKVASAMDLQLGKSTVRQFSDGEIQVNI
EESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRASAEKISVVMPYYGY
ARQDRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDH
LMGAPLIADYFDRHGLVGEDVVVVSPDHGGVTRARKLAQFLQTPIAIIDK
RRSVDKMNTSEVMNIIGNVSGKKCILIDDMIDTAGTICHAADALAEAGAT
AVYASCTHPVLSGPALDNIQRSAIEKLIVLDTIYLPKERLIDKIEQISIA
DLVAEAIIRIHEKRPLSPLFEMGN
>M28_Spy0678 punA, purine nucleoside phosphorylase
MSLMTKINETKDFLVAKGIEAPEFGLILGSGLGELAEEVENPVVIDYADI
PNWGKSTVVGHAGKLVYGDLAGRKVLALQGRFHFYEGNPLEVVTFPVRVM
KALGCEGVLVTNAAGGIGYGPGTLMAITDHINMTGNNPLIGENLDEFGPR
FPDMSDAYTKVYRNKAHEVAEKMNIKLEDGVYMGLTGPTYETPAEIRAFK
VLGADAVGMSTVPEVIVAAHSGLKVLGISAITNFAAGFQSELNHEEVVEV
TEHIKEDFKGLVKAILAEL
>M28_Spy0134 purA, adenylosuccinate synthetase
MTSVVVVGTQWGDEGKGKITDFLSADAEVIARYQGGDNAGHTIVIDGKKF
KLHLIPSGIFFPQKISVIGNGVVVNPKSLVKELAYLHDEGVTTDNLRISD
RAHVILPYHIQLDQLQEDAKGDNKIGTTIKGIGPAYMDKAARVGIRIADL
LDKDIFAERLRINLAEKNRLFEKMYDSTPLDFDAIFEEYYAYGQEIKQYV
TDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIG
SGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDEVGERIREVGHEYGTTT
GRPRRVGWFDSVVMRHSRRVSGITNLSLNSIDVLSGLDTVKICVAYDLDG
KRIDYYPASLEQLKRCKPIYEELPGWQEDITGVRSLDELPENARNYVRRV
GELVGVRISTFSVGPGREQTNILESVWASI
>M28_Spy0033 purB, adenylosuccinate lyase
MIERYSRPEMAAIWTEENKYRAWLEVEILADEAWAELGEIPKEDVAKIRE
KADFDIDRILEIEQETRHDVVAFTRAVSETLGEERKWVHYGLTSTDVVDT
AYGYLYKQANDIIRRDLENFTNIVADKAREHKMTIMMGRTHGVHAEPTTF
GLKLATWYSEMKRNIERFEHAAAGVEAGKISGAVGNFANIPPFVEEYVCD
KLGIRPQEISTQVLPRDLHAEYFAVLASIATSIERMATEIRGLQKSEQRE
VEEFFAKGQKGSSAMPHKRNPIGSENMTGLARVIRGHMVTAYENVSLWHE
RDISHSSAERIITPDTTILIDYMLNRFGNIVKNLTVFPENMMRNMESTFG
LIYSQRVMLKLIEKGMTREEAYDLVQPKTAYSWDNQVDFKPLLEEDTKVT
SCLTQEELDELFNPIYYTKRVDDIFKRLGI
>M28_Spy0022 purC, phosphoribosylaminoimidazole-succinocarboxamidesynthase
MKTERKANNQVTNQLIYKGKAKDIYSTKDENVIRTVYKDQATMLNGARKE
TIDGKGALNNQISSLIFEKLNKAGVVTHYIEQISKNEQLNKKVDIIPLEV
VLRNVIAGSFSKRFGVEEGRVLETPIVEFYYKNDDLNDPFINDEHVKFLG
IVNDEEIAYLKGETRRINELLKGWFAQIGLNLIDFKLEFGFDQEGTIILA
DEFSPDNCRLWDKNGNHMDKDVFRRDLGNLTDVYQVVLEKLIAL
>M28_Spy0029 purD, phosphoribosylamine--glycine ligase
MANRVFLISRIVVYYHIFTMFQLLITNTLCKKANVYDIISNYNTKEVDVL
KLLVVGSGGREHAIAKKLLASKGVDQVFVAPGNDGMTLDGLDLVNIVVSE
HSRLIAFAKENEISWAFIGPDDALAAGIVDDFNSAGLRAFGPTKAAAELE
WSKDFAKEIMVKYNVPTAAYGTFSDFEKAKAYIEEQGVPIVVKADGLALG
KGVVVAETVEQAVEAAQEMLLDNKFGDSGARVVIEEFLDGEEFSLFAFVN
GDKFYIMPTAQDHKRAFDGDKGPNTGGMGAYAPVPHLPQSVVDTAVETIV
RPVLEGMVAEGRPYLGVLYVGLILTADGPKVIEFNSRFGDPETQIILPRL
TSDFAQNIDDIMMGIEPYITWQKDGVTLGVVVASEGYPLDYEKGVPLPEK
TDGDIITYYAGAKFVENSELLLSNGGRVYMLVTTEDSVKAGQDKIYTQLA
QQDTTGLFYRNDIGSKAIRE
>M28_Spy0030 purE, phosphoribosylaminoimidazole carboxylase catalytic subunit
MLKHLVALTWVRLRNQRFRTYRIFFYGNFRQVETPLCILIMKTPIISIIM
GSKSDWATMQKTAEVLDNFGIAYEKKVVSAHRTPDLMFKHAEEARGRGIK
IIIAGAGGAAHLPGMVAAKTTLPVIGVPVKSRALSGLDSLYSIVQMPGGV
PVATMAIGEAGATNAALTALRILSIEDQNLADALAHFHEEQGKIAEESSG
ELI
>M28_Spy0024 purF, amidophosphoribosyltransferase
MCEKLSIFALLDSLCIEVKMTYEVKSLNEECGVFGIWGHPQAAQVTYFGL
HSLQHRGQEGAGIVSNDNGKLYGYRNVGLLSEVFKNQSELDNLTGNAAIG
HVRYATAGSADIRNIQPFLYKFHDGQFALCHNGNLTNAISLRKELEKQGA
IFNASSDTEILMHLIRRSHNSSFMGKVKEALNTVKGGFAYLLMTENKLIA
ALDPNAFRPLSIGQMQNGAWVISSETCAFEVVGAKWVRDVEPGEVILIDD
RGIQCDRYTDETQLAICSMEYVYFARPDSTIHGVNVHTARKNMGKRLAQE
FKQDADIVIGVPNSSLSAAMGFAEESGLPNEMGLVKNQYTQRTFIQPTQE
LREQGVRMKLSAVSGVVKGKRVVMIDDSIVRGTTSRRIVGLLREAGASEV
HVAIASPELKYPCFYGIDIQTRRELISANHAADEVCDIIGADSLTYLSLD
GLIESIGLETKAPNGGLCVAYFDGHYPTPLYDYEEEYLRSLEEKTSFYIQ
KVK
>M28_Spy0027 purH, phosphoribosylaminoimidazolecarboxamideformyltransferase
MTKRALISVSDKSGIVDFAKELKNLGWDIISTGGTKVALDNAGVETIAID
DVTGFPEMMDGRVKTLHPNIHGGLLARRDADSHLQAAKDNNIELIDLVVV
NLYPFKETILRPDITYDLAVENIDIGGPSMLRSAAKNHASVTVVVDPADY
ATVLGELADAGQTTFETRQRLAAKVFRHTAAYDALIAEYFTTQVGEAKPE
KLTITYDLKQAMRYGENPQQDADFYQKALPTDYSIASAKQLNGKELSFNN
IRDADAAIRIIRDFKDRPTVVVLKHMNPCGIGQADDIETAWDYAYEADPV
SIFGGIVVLNREVDAATAKKMHPIFLEIIIAPSYSEEALAILTNKKKNLR
ILELPFDAQAASEVEAEYTGVVGGLLVQNQDVVAENPSDWQVVTDRQPTE
QEATALEFAWKAIKYVKSNGIIITNDHMTLGLGAGQTNRVGSVKIAIEQA
KDHLDGAVLASDAFFPFADNIEEIAAAGIKAIIQPGGSVRDQDSIDAANK
HGLTMIFTGVRHFRH
>M28_Spy0031 purK, phosphoribosylaminoimidazole carboxylase ATPase subunit
MRNKEKSQRSQVVNSFKTIGIIGGGQLGQMMAIAAIYMGYKVITLDPASD
CPASRVSEVIVAPYDDVEALGQLAARCDVLTYEFENIDADGLDAVVSACQ
LPQGTDLLRISQNRIFEKDFLANKAGVTVAPYKVVTSSLDLGGLDFTKTY
VLKTATGGYDGHGQKVIRSAEDLPEAQQLANSAQCVLEEFVNFDLEISVI
VSGNGEDVTVFPVQENIHCNNILSKTIVPARISDQLADKAKKMAVQIAKK
LQLSGTLCVEMFATADDIIVNEIAPRPHNSGHYSIEACDFSQFDTHILGV
LGAPLPTIHLHAPAVMLNVLGQHVQQAIDYVAQNPSAHLHMYGKLEAKHN
RKMGHVTVFSDLPDEVEEF
>M28_Spy0023 purL, phosphoribosylformylglycinamidine synthase
MSSYFPVAPLSDLVSYMNKRIFVEKKADFGIKSASLVKELTHNLQLTSLK
ALRIVQVYDVFNLAEDLLARAEKHIFSEQVTDCLLTETEITAELDKVAFF
AIESLPGQFDQRAVSSQEALLLFGSDSQVKVNTAQLYLVNKDIAEAELEA
VKNYLLNPVDSRFKDITLPLEEQAFSVSDKTIPNLDFFETYKADDFTAYK
VEQGLAMEVDDLLFIQDYFKSIGRVPTETELKVLDTYWSDHCRHTTFETE
LKNIDFSASKFQKQLQTTYDKYIAMRDELGRSEKPQTLMDMATIFGRYER
ANGRLDDMEVSDEINACSVEIEVDVDGVKEPWLLMFKNETHNHPTEIEPF
GGAATCIGGAIRDPLSGRSYVYQAMRISGAGDITTPIAETRAGKLPQQVI
SKTAAHGYSSYGNQIGLATTYVREYFHPGFVAKRMELGAVVGAAPKENVV
REKPEAGDVVILLGGKTGRDGVGGATGSSKVQTVESVETAGAEVQKGNAI
EERKIQRLFRAGNVTRLIKKSNDFGAGGVCVAIGELADGLEIDLDKVPLK
YQGLNGTEIAISESQERMSVVVRPSDVDAFIAACNKENIDAVVVATVTEK
PNLVMTWNDETIVDLERRFLDTNGVRVVVDAKVVDKDLTVPEARITSAET
LEADTLKVLSDLNHASQKGLQTIFDSSVGRSTVNHPIGGRYQITPTESSV
QKLPVQHGVTTTASVMAQGYNAYIAEWSPYHGAAYAVIEATARLVATGAD
WSRARFSYQEYFERMDKQAERFGQPVSALLGSIEAQIQLGLPSIGGKDSM
SGTFEDLTVPPTLVAFGVTTADSRKILSPEFKAAGENIYYIPGQAISEDI
DFDLIKANFSQFEAIQTQHKITAASAVKYGGVLESFALMTFGNRIGASVE
IAELDSSLTAQLGGFVFTSAEEIADAVKIGQTQADFTVTVNGNDLAGASL
LAAFEGKLEEVYPTEFEQTDVLEEVPAVVSDTVIKAKETIEKPVVYIPVF
PGTNSEYDSAKAFEQVGASVNLVPFVTLNEVAIAESVDTMVANIAKANII
FFAGGFSAADEPDGSAKFIVNILLNEKVRAAIDSFIEKGGLIIGICNGFQ
ALVKSGLLPYGNFEEAGETSPTLFYNDANQHVAKMVETRIANTNSPWLAG
VEVGDIHAIPVSHGEGKFVVSASEFAELRDNGQIWSQYVDFDGQPSMDSK
YNPNGSVNAIEGITSKNGQIIGKMGHSERWEDGLFQNIPGNKDQTLFASA
VKYFTGK
>M28_Spy0025 purM, phosphoribosylformylglycinamidine cyclo-ligase
MSEKNAYAKSGVDVEAGYEVVERIKKHVARTERAGVMGALGGFGGMFDLS
KTGVREPVLVSGTDGVGTKLMLAIKYDKHDTIGQDCVAMCVNDIIAAGAE
PLYFLDYVATGKNNPVKFEEVVSGVAEGCVQAGAALIGGETAEMPGMYGE
DDYDLAGFAVGVAEKSQLIDGSKVKEGDILLGLASSGIHSNGYSLVRRVF
ADYTGKELLPELEGKQLKDVLLEPTRIYVRAALPLIKEELINGIGHITGG
GFIENVPRMFADDLAAEIDEDKVPVLPIFKALEKYGDIKHEEMFEIFNMG
VGLMLAVSPENVNRVKELLDEPVYEIGRIIKKADDSVVIK
>M28_Spy0026 purN, phosphoribosylglycinamide formyltransferase
MKIAVFASGNGSNFQVIAEQFPVSFVFSDHRDAYVLERAQNLAIPSFAFE
LKEFENKAAYEQAIVDLLDKHEIDLVCLTGYMKIVGETLLLAYEGRIINI
HPAYLPEFPGAHGIEDAWEAGVDQSGVTIHWVDSGVDTGQVIQQVRVPRL
ADDSLESFETRIHETEYQLYPAVLDSLGVERKVI
>M28_Spy0222 purR, pur operon repressor
MKLRRSERMVVISNYLINNPYKLTSLNTFATKYEAAKSSISEDIAIIKKA
FEEANIGDIDTLTGASGGVIFTPSISETEARTIVEDLCQRLSESDRILPG
GYIYLSDLLSTPKILQNIGRIIANAFKGEKIDAVMTVATKGVPLANAVAN
ILSVPFVIVRRDLKITEGSTVSVNYASASSDRIEKMFLSKRSLKPNSRVL
IVDDFLKGGGTITGMISLLTEFDSTLVGVAVFAENAQSEREQMTFKSLLK
VSEIDVKNNNVVVEVGNIFDKWKKEREWT
>M28_Spy0621 pyrB, aspartate carbamoyltransferase
MLLDHLHSHQSLVIKGIIMSVVNNRVALTNLVSMEALTTEEVLGLINRGS
EYKAGKVVISDHQKDLVANLFFENSTRTHKSFEVAEKKLGLTVLDFNADA
SAVNKGESLYDTVLTMSALGTDICVIRHPEDDYYKELVESPTITASIVNG
GDGSGQHPSQCLLDLLTIYEEFGRFEGLKIAIAGDLTHSRVAKSNMQILK
RLGAELYFYGPEEWYSEAFNAYGTYIAIDQIIKELDVLMLLRVQHERHDG
HQSFSKEGYHQAFGLTQERYQQLKDSAIIMHPAPVNRDVEIADSLVEAPK
ARIVSQMANGVFVRMAIIEAILNGRNKNS
>M28_Spy0689 pyrC, dihydroorotase
MLLIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLI
VAPGLVDIHVHFREPGQTHKEDIHTGALAAASGGVTTVVMMANTNPVISD
VETLQEVLASAAKEKIHIYTNASVTQAFNGKDVTDFKALLEAGAVSFSDD
GIPLESSKVLKEAFDLANANQTFISLHEEDPQLNGVLGFNEGIAEEHFHF
CGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVVAFAQQLGAKV
TAEVSPQHFSTTEDLLLIVGTSAKMNPPLRTQRDRLAVIEGLKSGVITVI
ATDHAPHHKDEKAVDDMTKAPSGMTGLETSLSLGLTHLVEPGHLTLMSLL
EKMTLNPALLYGFDAGYLAENGPADLVIFADKQERLITENFASKASNSPF
IGNKLKGVVKYTIADGEVVYPN
>M28_Spy1159 pyrD, dihydroorotate dehydrogenase
MEEIMVSTATQIGHFSFDNCLMNAAGVYCMTKEELMEVEKSQAASFVTKT
GTLEVRPGNPEPRYADTRLGSINSMGLPNNGFRYYLDFVSDLAKTGQHKP
HFLSVVGLSPTETETILKAIMASDYEGLVELNLSCPNVPGKPQIAYDFET
TDQLLENIFTYYTKPLGIKLPPYFDIVHFDQAAAIFNKYPLSFVNCVNSI
GNGLVIEDEQVLIKPKNGFGGIGGDYIKPTALANVHAFYKRLKPSIHIIG
TGGVKTGRDAFEHILCGASMVQIGTALHQEGPAIFERVTKELKTIMVEKG
YQSLDDFRGNLRYKD
>M28_Spy0684 pyrE, orotate phosphoribosyltransferase
MTLGSQIATQLLDIKAVYLKPEDPFTWASGIKSPIYTDNRVTLSYPKTRD
LIENGFVETIRAHFPEVEVIAGTATAGIPHGAIIADKMTLPFAYIRSKPK
DHGAGNQIEGRVLKGQKMVIIEDLISTGGSVLDAAAAASLEGADVLGVVA
IFTYELPKASQNFKEAGIKLITLSNYTELIAVAKLQGYITNDGLHLLKKF
KEDQVNWQQ
>M28_Spy0683 pyrF, orotidine 5'-phosphate decarboxylase
MKEERPIIALDFSSFEETKAFLDLFPAEEKLYVKIGMELYYAQGPDIVRS
IKSLGHNVFLDLKLHDIPNTVRAAMAVLKELDIDMATVHAAGGVEMLKAA
REGLGQGPTLIAVTQLTSTSEDQMRGDQNIQTSLLESVLHYSKGAAKAQL
DGVVCSAQEVEAIKAVTPTGFTCLTPGIRPKGSNIGDQKRVMTPNQARRI
GSDYIVVGRPITQAKDPVAAYQAIKAEWAG
>M28_Spy1599 pyrG, CTP synthase
MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGT
MSPYQHGEVYVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLR
KERKGEYLGATVQVIPHITDALKEKIKRAASTTDSDVIITEVGGTVGDIE
SLPFLEALRQMKADVGSENVMYIHTTLLPYLKAAGEMKTKPTQHSVKELR
GLGIQPNMLVIRTEEPVEQGIKNKLAQFCDVNSEAVIESRNVEHLYQIPL
NLQAQSMDQIVCDHLKLNAPQADMTEWSAMVDKVMNLRKTTKIALVGKYV
ELPDAYLSVVEALKHSGYANDTAIDLKWVNANDVTVDNAADLLGDADGII
VPGGFGQRGTEGKIQAIRYARENDVPMLGICLGMQLTCVEFARHVLNMEG
ANSFELEPSTKYPIIDIMRDQIDIEDMGGTLRLGLYPCKLKPGSKAAMAY
NNQEVVQRRHRHRYEFNNKFRPEFEAAGFVFSGVSPDNRLVEIVELKEKK
FFVAAQYHPELQSRPNRPEELYTAFVTAAIKNSN
>M28_Spy0365 pyrH, uridylate kinase
MEPKYQRILIKLSGEALAGEKGVGIDIPTVQAIAKEIAEVHVSGVQIALV
IGGGNLWRGEPAADAGMDRVQADYTGMLGTVMNALVMADSLQHYGVDTRV
QTAIPMQNVAEPYIRGRALRHLEKNRIVVFGAGIGSPYFSTDTTAALRAA
EIEADAILMAKNGVDGVYNADPKKDANAVKFDELTHGEVIKRGLKIMDAT
ASTLSMDNDIDLVVFNMNEAGNIQRVVFGEHIGTTVSNKVCD
>M28_Spy0620 pyrP, uracil permease
MKDVIYDVEEVPKAGMLVGLSFQHLFAMFGATVLVPILVGIDPSVALLSS
GLGTLAHLSVTKFKIPAYMGSSFAYIAAMQLLMKTNGIGAVAQGAMTGGL
VYLIVALIVKVIGNDWIDKILPPIVVGPIVMVIGLSLASTAVNDVMLKNG
NYNLTYLVIGLVTLLSVIFFNIYGKGIVAIVPLLLGLLVGYVVALLVGVL
TGQEIVDFTNVAQAKWFSIPSVEIPFLTYGVKFYPSAILTMAPIAFVTMT
EHFGHIMVLNSLTKRDYFKDPGLEKTLTGDGFAQIIAGFLGAPPVTSYGE
NIGVMALNKIFSVYVIAGAAVIAALLSFIGKVSALIQSIPTPVIGGISVA
LFGVIASSGLKILIESKVDMDNKKNLLIASVILVSGIGGLMLQVNGLQIS
GVAFSTLLGIILYQVLPEK
>M28_Spy0619 pyrR, PyrR
MKTKEIVDDVTMKRAITRITYEIIERNKQLDNVVLAGIKTRGVFLARRIQ
ERLHQLEGLDLPIGELDIKPFRDDMRVEEDTTLMSVDITGKDVILIDDVL
YTGRTIRAAIDNLVSLGRPARVSLAVLVDRGHRELPIRADYVGKNIPTSS
VEEIVVEVVEVDGRDRVSIIDPT
>M28_Spy0897 rnhB, anaerobic ribonucleoside-triphosphate reductase
MKRDDLMQIIKRDGHVADFDPDKIYQAIIKAARTVYVIDDTWRQNLTHVT
KKVVIDLEEAHVERPTINMVQSLVENRLMDAGYITIAEHYISYRLQRDLE
RNGYGDKIVVHLRFEQIK
>M28_Spy0836 tdk2, thymidine kinase
MAQLYYKYGTMNSGKTIEILKVAHNYEEQGKPVVIMTSALDTRDGFGIVS
SRIGMRREAIPISNDMDIFTFIAQLEEKPYCVLIDESQFLSKQNVYDLAR
VVDELNVPVMAFGLKNDFQNNLFEGSKHLLLLADKIDEIKTICQYCSKKA
TMVLRTENGKPVYEGDQIQIGGNETYIPVCRKHYFNPEI
>M28_Spy0668 thyA, thymidylate synthase
MLTERLLEMTKADQIFKANIQKIINEGSLSEQARPKYKDGRTAHSKYITG
AFAEYDLAKGEFPITTLRPIPIKSAIKELFWIYQDQSNSLDVLEAKYNVH
YWNEWEVDQTRTIGQRYGAVVKKHDIISKILKQLAENPWNRRNVISLWDY
EAFEETKGLLPCAFQIMFDVRRVGEDLYLDASLTQRSNDILVAHHINAMQ
YVALQMMIAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLKRQPVASQPK
LVLNVPDGTNFFDIKPDDFELQNYDPVKPQLHFDLAI
>M28_Spy0319 tmk, thymidylate kinase
MTVTSLIRTDRIGPKIEHCKDMPVLFSSFFDKIELLKSEGNKMITGKLIT
VEGPDGAGKTTVLEQLIPLLKQKVAQEILTTREPGGVAISEYIRELILDI
NHTTMDPKTELLLYIAARRQHLVEKVLPALEAGQLVFIDRFIDSSVAYQG
AGRGLIKADIQWLNEFATDGLEPDLTLYFDVPSEIGLARINANQQREVNR
LDLETIEIHQRVRKGYLALAKEHPKRIVTIDATKPLKEVVSVALEHVLAL
LLA
>M28_Spy1109 udk, uridine kinase
MEFKMLKKPIIIGVTGGSGGGKTSVSRAILDSFPNARIAMIQHDSYYKDQ
SHMSFEERVKTNYDHPLAFDTDFMIQQLKELLAGRPVDIPIYDYKKHTRS
NTTFRQDPQDVIIVEGILVLEDERLRDLMDIKLFVDTDDDIRIIRRIKRD
MMERGRSLESIIDQYTSVVKPMYHQFIEPSKRYADIVIPEGVSNVVAIDV
INSKIASILGEV
>M28_Spy1580 udp, uridine phosphorylase
MQNYSGEVGLQYHLQIRPGDVGRYVIMPGDPKRCAKIAEHFDNAVLVADS
REYVTYTGTLNGEKVSVTSTGIGGPSASIAMEELKLCGADTFIRVGTCGG
IDLDVKGGDIVIATGAIRMEGTSKEYAPIEFPAVADLEVTNALVNAAKKL
GYTSHAGVVQCKDAFYGQHEPERMPVSYELLNKWEAWKRLGTKASEMESA
ALFVAASHLGVRCGSDFLVVGNQERNALGMDNPMAHDTEAAIQVAVEALR
TLIENDKSQ
>M28_Spy0316 upp, uracil phosphoribosyltransferase
MGKCQVISHPLIQHKLSILRRQTTSTKDFRELVNEIAMLMGYEVSRDLPL
EDVDIQTPVSKTVQKQLAGKKLAIVPILRAGIGMVDGLLSLVPAAKVGHI
GMYRNEETLEPVEYLVKLPEDINQRQIFLVDPMLATGGSAILAVDSLKKR
GAANIKFVCLVAAPEGVKKLQEAHPDIDIFTAALDDHLNEHGYIVPGLGD
AGDRLFGTK
>M28_Spy0832 xpt, xanthine phosphoribosyltransferase
MQLLEERILTDGNILGENILKVDNFLTHQVDYRLMKAIGKVFAQKYAEAG
ITKVVTIEASGIAPAVYAAEAMDVPMIFAKKHKNITMTEGILTAEVYSFT
KQVTSTVSIAGKFLSKEDKVLIIDDFLANGQAAKGLIEIIGQAGAQVVGV
GIVIEKSFQDGRRLIEDMGIEVTSLARIKNFENGNLNFLEADA