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# Streptococcus pyogenes phage 5005.3

>M5005_Spy0775 nucleoside diphosphate kinase
MMRVTNPKDALCGTIRENFAQAPGDDGGIFNMVHGSHSRDSARREIAL
>M5005_Spy0023 phosphoribosylformylglycinamidine synthase
MSSYFPVAPLSDLVSYMNKRIFVEKKADFGIKSASLVKELTHNLQLTSLK
ALRIVQVYDVFNLAEDLLARAEKHIFSEQVTDCLLTETEITAELDKVAFF
AIEALPGQFDQRAASSQEALLLFGSDSQVKVNTAQLYLVNKDITEAELEA
VKNYLLNPVDSRFKDITLPLEEQAFSVSDKTIPNLDFFETYQADDFATYK
AEQGLAMEVDDLLFIQNYFKSIGCVPTETELKVLDTYWSDHCRHTTFETE
LKNIDFSASKFQKQLQTTYDKYIAMRDELGRSEKPQTLMDMATIFGRYER
ANGRLDDMEVSDEINACSVEIEVDVDGVKEPWLLMFKNETHNHPTEIEPF
GGAATCIGGAIRDPLSGRSYVYQAMRISGAGDITTPIAETRAGKLPQQVI
SKTAAHGYSSYGNQIGLATTYVREYFHPGFVAKRMELGAVVGAAPKENVV
REKPEAGDVVILLGGKTGRDGVGGATGSSKVQTVESVETAGAEVQKGNAI
EERKIQRLFRDGNVTRLIKKSNDFGAGGVCVAIGELADGLEIDLDKVPLK
YQGLNGTEIAISESQERMSVVVRPNDVDAFIAACNKENIDAVVVATVTEK
PNLVMTWNGEIIVDLERRFLDTNGVRVVVDAKVVDKDLTVPEARTTSAET
LEADTLKVLSDLNHASQKGLQTIFDSSVGRSTVNHPIGGRYQITPTESSV
QKLPVQHGVTTTASVMAQGYNPYIAEWSPYHGAAYAVIEATARLVATGAD
WSRARFSYQEYFERMDKQAERFGQPVSALLGSIEAQIQLGLPSIGGKDSM
SGTFEDLTVPPTLVAFGVTTADSRKVLSPEFKAAGENIYYIPGQAISEDI
DFDLIKDNFSQFEAIQAQHKITAASAAKYGGVLESLALMTFGNRIGASVE
IAELDSSLTAQLGGFVFTSAEEIADAVKIGQTQADFTVTVNGNDLAGASL
LAAFEGKLEEVYPTEFEQTDVLEEVPAVVSDTVIKAKETIEKPVVYIPVF
PGTNSEYDSAKAFEQVGASVNLVPFVTLNEVAIAESVDTMVANIAKANII
FFAGGFSAADEPDGSAKFIVNILLNEKVRAAIDSFIEKGGLIIGICNGFQ
ALVKSGLLPYGNFEEAGETSPTLFYNDANQHVAKMVETRIANTNSPWLAG
VEVGDIHAIPVSHGEGKLVVSASEFAELRDNGQIWSQYVDFDGQPSMDSK
YNPNGSVNAIEGITSKNGQIIGKMGHSERWEDGLFQNIPGNKDQILFASA
VKYFTGK
>M5005_Spy0845 ribose-phosphate pyrophosphokinase
MTERYADKQIKLFSLTSNLPIAEKIAKAAGIPLGKMSSRQFSNGEIMINI
EETVRGDDIYIIQSTSFPVNDNLWELLIMIDACKRASANTVNIVLPYFGY
SRQDRVAKPREPITAKLVANMLTKAGIDRVVTLDLHAVQVQGFFDIPVDN
LFTVPLFAERYSKLGLSGSDVVVVSPKNSGIKRARSLAEYLDSPIAIIDY
AQDDSEREQGYIIGDVSGKKAILIDDILNTGKTFAEAAKILERSGATDTY
AVASHGLFAGGAADVLETAPIKEIIVTDSVKTKNRVPENVTYLSASDLIA
EAIIRIHERRPLSPLFSYQPKGKNNA
>M5005_Spy0027 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
MTKRALISVSDKSGIVDFAKELKNLGWDIISTGGTKVTLDDAGVETIAID
DVTRFPEMMDGRVKTLHPNIHGGLLARRDADSHLQAAKDNNIELIDLVVV
NLYPFKETILRPDITYDLAVENIDIGGPSMLRSAAKNHASVTVVVDPADY
ATVLGELADAGQTTFETRQRLAAKVFRHTAAYDALIAEYFTTQVGEAKPE
KLTITYDLKQAMRYGENPQQDADFYQKALPTDYSIASAKQLNGKELSFNN
IRDADAAIRIIRDFKDRPTVVALKHMNPCGIGQADDIETAWDYTYKADPV
SIFGGIIVLNREVDAATAKKMHPIFLEIIIAPSYSEEALAILTNKKKNLR
ILELPFDAQAASEVEAEYTGVVGGLLVQNQDVVAENPSDWQVVTDRQPTE
QEATALEFAWKAIKYVKSNGIIITNDHMTLGLGAGQTNRVGSVKIAIEQA
KDHLDGAVLASDAFFPFADNIEEIAAAGIKAIIQPGGSVRDQDSIDAANK
HGLTMIFTGVRHFRH
>M5005_Spy0670 nucleoside diphosphate kinase
MIKPYGFKYGLVGEVLRRIERLGFTFERLELRQASSKYLAKHDEALVINL
FILDLKLT
>M5005_Spy0379 uridylate kinase
MRHLEKNRIVVFGAGIGSPYFSTDTTAALRAAEIEADAILMAKNGVDGVY
NADPKKDANAVKFDELTHGEVIKRGLKIMDATASTLSMDNDIDLVVFNMN
EAGNIQRVVFGEHIGTTVSNKVCD
>M5005_Spy0859 xanthine permease
MTHSTKQEHSHSQSAVLGLQHVLSMYAGSILVPIMIAGALGYSARELTYL
ISTDIFMCGVATFLQLKLTKHTGVGLPVVLGCAFQSVAPLSIIGAQQGSG
AKFGALIASGIYVILVAGIFSKIARFFPPIVTGSVITVIGLSLVGVAMGN
MGDNVKEPTAQSMMLSLLTIVIILLVQKFTKGFVKSISILIGLVAGTLVS
AMMGLVDTTPVVEASWIHVPTPFYFGMPTFEITSIVMMCIIATVSMVEST
GVYLALSDLTNDQLDEKRLRNGYRSEGIAVFLGGLFNTFPYTGFSQNVGL
VQISGIKTRRPIYYAAGILVVIGLLPKFGAMAQMIPSPVLGGAMLVLFGM
VALQGMQMLNRVDFQKNEYNFIIAAVSISAGLGFNGTNLFASLPETAQMF
LTNGIVIATLTSVVLNLVLNGKDKQDE
>M5005_Spy0179 tRNA-specific adenosine deaminase
MPYSLEEQTYFMQEALKEAEKSLQKAEIPIGCVIVKDGEIIGRGHNAREE
SNQAIMHAEMMAINEANAHEGNWRLLDTTLFVTIEPCVMCSGAIGLARIP
HVIYGASNQKFGGVDSLYQILTDERLNHRVQVERGLLAADCANIMQTFFR
QGRERKKIAKHLIKEQSDPFD
>M5005_Spy0012 hypoxanthine-guanine phosphoribosyltransferase
MLEQDIQKILYSENDIIRKTKKLGEQLTKDYQEKNPLMIGVLKGSVPFMA
ELMKHIDTHVEIDFMVVSSYHGGTSSSGEVKILKDVDTNIEGRDIIIVED
IIDTGRTLKYLRDMFKYRKANTIKIATLFDKPEGRVVKIEADYVCYNIPN
EFIVGFGLDYAENYRNLPYVGVLKEEVYSK
>M5005_Spy0080 bis(5'-nucleosyl)-tetraphosphatase(asymmetrical)
MTECIFCHQLKANQLLTQSQYFKVVFDIDPIQKGHLLLISKDHYTSLTQL
PKEGHYDLIDLQAALVAKLEQHLPISGVTSVSNDKELMDEGTHFHLHLIP
RLTNDSFWEGITINQENWDLTPFLKHL
>M5005_Spy0022 phosphoribosylaminoimidazole-succinocarboxamidesynthase
MKTERKANNQVTNQLIYKGKAKDIYSTKDENVIRTVYKDQATMLNGARKE
TIDGKGALNNQISSLIFEKLNKAGVVTHYIEQISKNEQLNKKVDIIPLEV
VLRNVTAGSFSKRFGVEEGHVLETPIVEFYYKNDDLDDPFINDEHVKFLG
IVNDEEIAYLKGETRRINELLKGWFAQIGLNLIDFKLEFGFDQEGTIILA
DEFSPDNCRLWDKNGNHMDKDVFRRDLGNLTDVYQVVLEKLIAL
>M5005_Spy1690 nrdl.1
MPQITLVFISLSGNTLSFVKRLSLYLADNYDYHVKQINIKDLKHETFPVK
EEFVAILPTYLEGGNGVDSGDVEILTTPLGEFIAAHGNAQRCLGIIGSGN
KNFNHQYCLTAKQYAKRFGFPLLGDFELRGTPDDISRLAQVIMEASSRHS
SNDTQTLPNS
>M5005_Spy0774 nucleoside diphosphate kinase
MIKPYGVKQGEVVGEVLRWIERLRFTFKRFELRQASSKYLAKHDEALVIN
LLILNLKLT
>M5005_Spy0199 deoxyuridine 5'-triphosphate nucleotidohydrolase
MTKIRGFELVSSFTNPDLLPKRETTHAAGYDLSVAEAVTIAPGEIKLVPT
GVKAYMQDGEVLYLYDRSSNPRKKGIILINSVGVIDADYYGNEANEGHIF
AQMQNITDHPVTLAVGERIVQGVFMPFLIADGDQARGERTGGFGSTGQ
>M5005_Spy1609 CTP synthase
MSPYQHGEVYVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLR
KERKGEYLGATVQVIPHITDALKEKIKRAASTTDSDVIITEVGGTVGDIE
SLPFLEALRQMKADVGSENVMYIHTTLLPYLKAAGEMKTKPTQHSVKELR
GLGIQPNMLVIRTEEPVEQGIKNKLAQFCDVNSEAVIESRDVEHLYQIPL
NLQAQSMDQIVCDHLKLNAPQADMTEWSAMVDKVMNLRKTTKIALVGKYV
ELPDAYLSVVEALKHSGYANDTAIDLKWVNANDVTVDNAADLLGDADGII
VPGGFGQRGTEGKIQAIRYARENDVPMLGICLGMQLTCVEFARHVLNMEG
ANSFELEPSTKYPIIDIMRDQIDIEDMGGTLRLGLYPCKLKPGSKAAMAY
NNQEVVQRRHRHRYEFNNKFRPEFEAAGFVFSGVSPDNRLVEIVELKEKK
FFVAAQYHPELQSRPNRPEELYTAFVTAAIKNSN
>M5005_Spy0304 xanthosine triphosphate pyrophosphatase
MSEKIYEYKDENNWFIGKMTGHNLISGWGVKHTTIKKIDDLLDGIAATLD
WENPKGYDVSVVRHQSPLSLITFIIDMINQETQREIKVTPHAGTILLMEN
AKLLAVYLPEGGVSTATFFATSEQGFGDIILIATRNEGKTKEFRNLFGQL
GYRVENLNDYPELPEVAETGTTFEENARLKAETISRLTGKMVLADDSGLK
VDALGGLPGVWSARFSGPDATDAKNNAKLLHELAMVFDQKKRSAQFHTTL
VVAAPNKDSLVVEADWPGYIATQPKGENGFGYDPVFIVGETGHHAAELEA
DQKNQLSHRGQAVRKLMEVFPAWQAKQS
>M5005_Spy0103 deoxyadenosine kinase/deoxyguanosine kinase
MLIVLAGTIGAGKSSLAAALGEHLGTDVFYEAVDNNPVLDLYYQDPKKYA
FLLQIYFLNKRFKSIKEAYQADNNILDRSIFEDELFLKLNYKNGNVTKTE
LDIYQELLANMLEELEGMPKKRPDLLIYIDVSFDKMLERIERRGRSFEQV
DGNPSLEQYYHQVHGEYPTWYEDYEVSPKMKIDGNSLDFVQNPQDLATVL
KMIDTKLKELHLL
>M5005_Spy0377 uridylate kinase
MEPKYQRILIKLSGEALAGEKGVGIDIPTVQAIAKEIAEVHVSGVQIALV
IGGGNL
>M5005_Spy1097 phosphorylase, Pnp/Udp family
MDWLIGYGVKEMISTGTCGVLVPIAENRFLVPVKALRDEGTSYHYVAPSR
YIDIDPKMLRLIEKTLLAQGLAYQEVITWSTDGFYRETKEKVAYRQEEGC
SVVEMECSALAAVAQLRGILWGQLLFTADTLADVEVYDQRNWGADSFSFA
LHLCLEVLNTLEKDGKATDF
>M5005_Spy0678 5'-nucleotidase
MKKYFILKSSVLSILTSFTLLVTDVQADQVDVQFLGVNDFHGALDNTGTA
YTPSGKIPNAGTAAQLGAYMDDAEIDFKQANQDGTSIRVQAGDMVGASPA
NSALLQDEPTVKVFNKMKFEYGTLGNHEFDEGLDEFNRIMTGQAPDPEST
INDITKQYEHEASHQTIVIANVIDKKTKDIPYGWKPYAIKDIAINDKIVK
IGFIGVVTTEIPNLVLKQNYEHYQFLDVAETIAKYAKELQEQHVHAIVVL
AHVPATSKDGVVDHEMATVMEKVNQIYPEHSIDIIFAGHNHQYTNGTIGK
TRIVQALSQGKAYADVRGTLDTDTNDFIKTPSANVVAVAPGIKTENSDIK
AIINHANDIVKTVTERKIGTATNSSTISKTENIDKESPVGNLATTAQLTI
AKKTFPTVDFAMTNNGGIRSDLVVKNDRTITWGAAQAVQPFGNILQVIQM
TGQHIYDVLNQQYDENQTYFLQMSGLTYTYTDNDPKNSDTPFKIVKVYKD
NGEEINLTTTYTVVVNDFLYGGGDGFSAFKKAKLIGAINTDTEAFITYIT
NLEASGKTVNATIKGVKNYVTSNLESSTKVNSAGKHSIISKVFRNRDGNT
VSSEVISDLLTSTENTNNSLGKKETTTNKNTISSSTLPITGDNYKMSPIM
TILALISLGGLNAFIKKRKS
>M5005_Spy0065 adk, adenylate kinase
MNLLIMGLPGAGKGTQAAKIVEEFGIAHISTGDMFRAAMANQTEMGRLAK
SYIDKGELVPDEVTNGIVKERLAEDDIAEKGFLLDGYPRTIEQAHALDAT
LEELGLRLDGVINIKVDPSCLVERLSGRIINRKTGETFHKVFNPPVDYKE
EDYYQREDDKPETVKRRLDVNMAQGEPILEHYRKLGLVTDIEGNQEITDV
FADVEKALLELK
>M5005_Spy0728 apt, adenine phosphoribosyltransferase
MDLTNYIASIKDYPKAGITFRDISPLMADGKAYSYAIREIAQYACDKDID
MVVGPEARGFIIGCPVAVELGIGFAPVRKPGKLPRDVVSADYEKEYGLDT
LTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGIVAGCAFLIEL
EGLNGRHAIRNYDYKVLMQFPG
>M5005_Spy0642 carA, carbamoyl-phosphate synthase small chain
MTKRLLILEDGTIFEGEPFGADIDVTGEIVFNTGMTGYQESITDQSYNGQ
ILTFTYPLIGNYGINRDDYESISPTCKGVVVSEVSRLASNWRKQMTLDAF
LKIKGIPGISGIDTRALTKIIRQHGTMKATMADDGDSIQHLKDQLRATVL
PTNTIEQVSTKTAYPAPGIGKNIVLVDFGLKHSILREFSKRQCNITVVPF
NITAEEVLQLNPDGLMLSNGPGNPEDLPEALDMIRGVQGKIPIFGICMGH
QLFSLANGAKTCKMTFGHRGFNHAVREIATGRIDFTSQNHGYAVERSSLP
DTLMVTHEDINDKTVEGVKHRDFPAFSVQFHPDAAPGPHDASYLFDEFLE
MIDSWRCTSK
>M5005_Spy0643 carB, carbamoyl-phosphate synthase large chain
MPKRKDIQKIMVIGSGPIIIGQAAEFDYAGTQACLALKEEGYKVILVNSN
PATIMTDKEIADKVYIEPLTLEFVNRIIRKERPDAILPTLGGQTGLNMAM
ALSKAGILDDLEIELLGTKLSAIDQAEDRDLFKQLMQELDQPIPESTIVK
TVDEAVTFARDIGYPVIVRPAFTLGGTGGGICSSEEELCEITENGLKLSP
VTQCLIERSIAGFKEIEYEVMRDSADNALVVCNMENFDPVGIHTGDSIVF
APTQTLSDIENQMLRDASLKIIRALKIEGGCNVQLALDPYSFKYYVIEVN
PRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMINPITGTTYAMFEPAL
DYVVAKIPRFPFDKFEHGERQLGTQMKATGEVMAIGRNLEESLLKACRSL
EIGVCHNEMTSLSNISDEELVTKVIKAQDDRLFYLSEAIRRGYSIEELES
LTKIDLFFLDKLLHIVEIEQELQMHVDHLESLKKAKRYGFSDQKIAEIWQ
KDESDIRAMRHSHSLYPVYKMVDTCAAEFDAKTPYFYSTYELENESVQSN
KESILVLGSGPIRIGQGVEFDYATVHSVKAIQKAGYEAIIMNSNPETVST
DFSVSDKLYFEPLTFEDVMNVIDLEQPKGVIVQFGGQTAINLAQALSEAG
VTILGTQVEDLDRAEDRDLFEKALKELGIPQPQGQTATNEEEALEAAKKI
GFPVLVRPSYVLGGRAMEIVENKEDLREYIRTAVKASPEHPILVDSYIFG
KECEVDAISDGKSVLIPGIMEHIERAGVHSGDSMAVYPPQQLSKQIQETI
AEYTKRLAIGLNCIGMMNVQFVIKNEQVYVIEVNPRASRTVPFLSKVTGI
PMAQIATKLILGQTLKDLGYEDGLYPQSPLVHIKAPVFSFTKLAQVDSLL
GPEMKSTGEVMGSDTSLEKALYKAFEANNSHLSEFGQIVFTIADDSKAEA
LSLARRFKAIGYQIMATQGTAAYFAEQGLSACLVGKIGDAANDIPTLVRH
GHVQAIVNTVGIKRTADKDGQMIRSSAIEQGVPLFTALDTAKAMLTVLES
RCFNIEAI
>M5005_Spy0943 cdd, cytidine deaminase
MGTTDLVSCAVQASEYAYVPYSHFPVGAALKTKDGTIYTGCNIENVSFGL
TNCGERTAIFKAISDGHKELVEIAIYGETMQPVSPCGACRQVMAEFFDPS
SLVTLIAKNGQTVEMTVGDLLPYSFTDLI
>M5005_Spy0618 cmk, cytidylate kinase
MKAIKIAIDGPASSGKSTVAKIIAKNLGYTYLDTGAMYRSATYIALTHGY
TGKEVALILEELEKNPIFFKKAKDGSQLVFLGDEDVTLAIRQNDVTNNVS
WISALPEIREELVHQQRRIAQAGGIIMDGRDIGTVVLPDAELKIFLVASV
EERAERRYKENLEKGIESDFETLKEEIAARDYKDSHRKVSPLKAAEDALI
FDTTGVSIDGVVQFIQEKAEKIVDMS
>M5005_Spy1548 comEB, comE operon protein 2
MTNRLSWQDYFMANAELISKRSTCDRAFVGAVLVKDNRIIATGYNGGVSA
TDNCNEAGHYMEDGHCIRTVHAEMNALIQCAKEGISTDGTEIYVTHFPCI
NCTKALLQAGITKITYKAHYRPHPFAIELMEKKGVAYVQHDVPQIVLGGD
KEQ
>M5005_Spy1585 deoC, deoxyribose-phosphate aldolase
MEVKDILKTVDHTLLATTATWPEIQTILDDAMAYETASACIPASYVKKAA
EYVSGKLAICTVIGFPNGYSTTAAKVFECQDAIQNGADEIDMVINLTDVK
NGDFDTVEEEIRQIKAKCQDHILKVIVETCQLTKEELIELCGVVTRSGAD
FIKTSTGFSTAGATFEDVEVMAKYVGEGVKIKAAGGISSLEDAKTFIALG
ASRLGTSRIIKIVKNEATKTDSY
>M5005_Spy0699 deoD2, purine nucleoside phosphorylase
MSIHISAKKGDIADKILLPGDPLRAKFIAENFLEDAVCFNEVRNMFGYTG
TYKGHRVSVMGTGMGMPSISIYARELIVDYGVKTLIRVGTAGAIDPEVHV
RELVLAQAAATNSNIIRNDFPEFDFPQIADFGLLDKAYHIAREMGVTTHV
GNVLSSDVFYTNMPERNMALGKLGVKAIEMEAAALYYLAAQHHVKALGIM
TISDNLNDPTEDTTAEERQTTFTDMMKVGLETLIAND
>M5005_Spy0927 fhs.1, formate--tetrahydrofolate ligase
MKSDIEIAQSVALQPITDIVKKVGIDGDDIELYGKYKAKLSFEKMKAVEA
NEPGKLILVTAINPTPAGEGKSTMSIGLADALNQMGKKTMLALREPSLGP
VMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLQQ
GNDLGIDPRRIIWKRVLDLNDRALRQVIVGLGSPVNGVPREDGFDITVAS
EIMAILCLATDLKDLKKRLADIVVAYTYDRKPVYVRDLKVEGALTLILKD
AIKPNLVQTIYGTPALIHGGPFANIAHGCNSVLATSTALRLADYTVTEAG
FGADLGAEKFLNIKVPNLPKAPDAIVIVATLRALKMHGGVAKSDLAAENC
EAVRLGFANLKRHVENMRQFKVPVVVAINEFVADTEAEIATLKALCEEIK
VPVELASVWANGAEGGLALAKTVVRVIDQEAADYKRLYSDEDTLEEKVIN
IVTQIYGGKAVQFGPKAKTQLKQFAEFGWDKLPVCMAKTQYSFSDNPSLL
GAPTDFDITIREFVPKTGAGFIVGLTGDVMTMPGLPKVPAAMAMDVAENG
TALGLF
>M5005_Spy1774 fhs.2, formate--tetrahydrofolate ligase
MVLSDIEIANSVTMEPISKVADQLGIDKEALCLYGKYKAKIDARQLVALK
NKPDGKLILVTAISPTPAGEGKTTTSVGLVDALSAIGKKAVIALREPSLG
PVFGVKGGAAGGGHAQVVPMEDINLHFTGDFHAIGVANNLLAALIDNHIH
HGNSLGIDSRRITWKRVVDMNDRQLRHIVDGLQGKVNGIPREDGYDITVA
SEIMAILCLSENISDLKARLEKIIIGYNYQGEPVTAKDLKAGGALAALLK
DAIHPNLVQTLEHTPALIHGGPFANIAHGCNSVLATKLALKYGDYAVTEA
GFGADLGAEKFIDIKCRMSGLRPAAVVLVATIRALKMHGGVPKADLATEN
VQAVVDGLPNLDKHLANIQDVYGLPVVVAINKFPLDTDAELQAVYDACDK
RGVDVVISDVWANGGAGGRELAEKVVTLAEQDNQFRFVYEEDDSIETKLT
KIVTKVYGGKGINLSSAAKRELADLERLGFGNYPICMAKTQYSFSDDAKK
LGAPTDFTVTISNLKVSAGAGFIVALTGAIMTMPGLPKVPASETIDIDEE
GNITGLF
>M5005_Spy1701 flaR, DNA topology modulation protein flar-related protein
MKIAIIGHSGSGKSTLARFLGQHYHCEVFHLDQLHFSSNWQERSDHDMIA
DLSTCLLKQDLIIEGNYANCLYEERMSEADYIIYVNFSRFHCVYRAFKRY
LNYRGKTRPDMADNCQEKFDVAFVKWILLDGRSRNQLKKYQSVVQKYSHK
TIVLTNQKQLSHYMNTIN
>M5005_Spy1341 gmk, guanylate kinase
MSERGLLIVFSGPSGVGKGTVRQEIFSTPDHKFEYSVSMTTRPQRPGEVD
GVDYFFRTREEFEELIKTGQMLEYAEYVGNYYGTPLTYVNETLDKGIDVF
LEIEVQGALQVKSKVPDGVFVFLTPPDLDELEDRLVGRGTDSQEVIAQRI
ERAKEEIALMREYDYAVVNDEVALAAERVKRIIETEHFRVERVIGRYDKM
IKITKNSFKAK
>M5005_Spy0919 guaA, GMP synthase (glutamine-hydrolyzing)
MTEISILNDVQKIIVLDYGSQYNQLIARRIREFGVFSELKSHKITAQELR
EINPIGIVLSGGPNSVYADNAFGIDPEIFELGIPILGICYGMQLITHKLG
GKVVPAGQAGNREYGQSTLHLRETSKLFSGTPQEQLVLMSHGDAVTEIPE
GFHLVGDSNDCPYAAIENTEKNLYGIQFHPEVRHSVYGNDILKNFAISIC
GARGDWSMDNFIDMEIAKIRETVGDRKVLLGLSGGVDSSVVGVLLQKAIG
DQLTCIFVDHGLLRKDEGDQVMGMLGGKFGLNIIRVDASKRFLDLLADVE
DPEKKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDIIESGTETAQTI
KSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGIALGMPEEIVWRQPFPG
PGLAIRVMGAITEEKLETVRESDAILREEIAKAGLDRDVWQYFTVNTGVR
SVGVMGDGRTYDYTIAIRAITSIDGMTADFAQLPWDVLKKISTRIVNEVD
HVNRIVYDITSKPPATVEWE
>M5005_Spy0857 guaC, GMP reductase
MFNDIPVFDYEDIQLIPNKCIITSRSQADTSVTLGKYQFKLPVIPANMQT
IIDETIAEQLAKEGYFYIMHRFDEDSRKPFIKRMHEQGLIASISVGVKAC
EYEFVTSLKEDAPEFITIDIAHGHANSVIDMIKHIKTELPETFVIAGNVG
TPEAVRELENAGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKA
ARKPIIADGGIRTHGDIAKSIRFGASMVMIGSLFAGHFESPGKTVEVDGE
TFKEYYGSASEYQKGEHKNVEGKKILLPTKGHLSDTLTEMQQDLQSSISY
AGGKDLDSLRHVDYVIVKNSIWNGDSI
>M5005_Spy1472 hit, bis(5'-nucleosyl)-tetraphosphatase(asymmetrical)
MENCIFCSIIQGDIPSSKVYEDEQVLAFLDISQTTKGHTLVIPKQHVRNL
LEMTAETASHLFARIPKIARAIQSATGATAMNIINNNEALAGQTVFHAHV
HLVPRYNEEDGISIQYTTHEPDFPVLEKLARQINQEVSS
>M5005_Spy1793 nrdD, anaerobic ribonucleoside-triphosphate reductase
MVSLEEDKVTVQPDIKVIKRDGRLVNFDSTKIYSALLKASMKVTRMSPLV
EAKLEAISDRIIAEIIERFPTNIKIYEIQNIVEHKLLAANEYAIAKEYIN
YRTQRDFARSQATDINFSIDKLINKDQTVVNENANKDSDVFNTQRDLTAG
IVGKSIGLKMLPSHVANAHQKGDIHYHDLDYSPYTPMTNCCLIDFKGMLA
NGFKIGNAEVESPKSIQTATAQISQIIANVASSQYGGCTADRIDEFLAPY
AELNFKKHMADAKKWIVETKRESYAFEKTQKDIYDAMQSLEYEINTLFTS
NGQTPFTSLGFGLGTSWFEHEIQKAILTIRINGLGSEHRTAIFPKLIFTV
KRGLNLEPDSPNYDIKTLALECATKRMYPDMLSYDKIIDLTGSFKSPMGC
RSFLQGWKDENGQDVTSGRMNLGVVTLNLPRIAMESNGDMDKFWELFNER
MLISKDALIYRVERVTEAKPANAPILYQYGAFGKRLEKTGNVNDLFKNRR
ATVSLGYIGLYEVASVFYGGQWEGNPDAKAFTLSIVKAMKQACEDWSDEY
GYHFSVYSTPSESLTDRFCRLDTEKFGIVTDITDKEYYTNSFHYDVRKSP
TPFEKLDFEKDYPEAGASGGFIHYCEYPVLQQNPKALEAVWDYAYDRVGY
LGTNTPIDKCYNCQFEGDFTPTERGFTCPNCGNNDPKTVDVVKRTCGYLG
NPQARPMVNGRHKEISARVKHMNGSTIKYPGL
>M5005_Spy0349 nrdE.1, ribonucleoside-diphosphate reductase alpha chain
MSQTNASYLSLNALTRFKKPDGSYHFDSDKEAVRRYLEEHVSPNQMAFNS
LEDKLAYLINEGYYEQAIFDAYPNDLIKEAFHYAYQQGYRFLNLMGAMKF
YQSYALKTLDGKQYLETFEDRAVMNALFLADGDQTFVFDVIDAILHRRFQ
PATPTFLNAGKKRRGEYISCYLLRVEDNMESISRAISTSLQLSKRGGGVA
LCLTNLREIGAPIKGIENQATGIVPVMKLLEDSFSYANQLGQRQGAGAVY
LHAHHPEVLTFLDTKRENADEKIRIKSLALGLVIPDITFQLAKENKDMAL
FSPYDIKRAYGKDMSDISITEEYDKLLANPAIKKTYISARKFFQLIAELH
FESGYPYLLFDDTVNKRNPHAKKGRIVMSNLCSEIAQVSTPSTFKEDLSF
ETIGEDICCNLGSINIAQAMADAPHFEQLITTSIRALDRVSRVSDLNCAP
SVETGNAANHAVGLGAMNLHGFLATNHIYYDTKEAVDFTDLFFHAMAYYA
FKASCQLAKEKGAFAGFSLSTYSDGTYFAKYLQEDAKPQTAKVATLLQDY
GFTLPTVADWQALVADIKQFGLANAHLLAVAPTGSISYLSSCTPSLQPVV
APVEVRKEGSLGRIYVPAYQIDQANYAYYERGAYEVGPKAIIDVVAAAQK
HVDQAISLTLFMTDQATTRDLNRSYIQAFKQNCASIYYVRVRQDVLAGSE
QYDEDSLVTAPGASDETTTECQSCMI
>M5005_Spy1123 nrdE.2, ribonucleoside-diphosphate reductase alpha chain
MSLKDLGDISYFRLNNEINRPVNGKIPLHKDKEALKAFSAENVLPNTMSF
TSITEKIEYLISNDYIESAFIQKYRPEFITELDSIIKSENFRFKSFMAAY
KFYQQYALKTNDGEHYLENLEDRVLFNALYFADGQEDLAKDLAVEMINQR
YQPATPSFLNAGRSRRGELVSCFLIQVTDDMNSIGRSINSALQLSRIGGG
VGITLSNLREAGAPIKGYAGAASGVVPVMKLFEDSFSYSNQLGQRQGAGV
VYLNVFHPDIIAFLSTKKENADEKVRVKTLSLGITVPDKFYELARKNEDM
YLFSPYNVEKEYGIPFNYLDITNMYDELVANPKITKTKIKARDLETEISK
LQQESGYPYIINIDTANKANPIDGKIIMSNLCSEILQVQTPSLINDAQEF
VEMGTDISCNLGSTNILNMMTSPDFGRSIKTMTRALTFVTDSSSIEAVPT
IKHGNSQAHTFGLGAMGLHSYLAQHHIEYGSPESIEFTDIYFMLLNYWTL
VESNNIARERQTTFVGFENSKYANGSYFDKYVTGHFVPKSDLVKDLFKDH
FIPQASDWEALRDAVQKDGLYHQNRLAVAPNGSISYINDCSASIHPITQR
IEERQEKKIGKIYYPANGLSTDTIPYYTSAYDMDMRKVIDVYAAATEHVD
QGLSLTLFLRSELPMELYEWKTQSKQTTRDLSILRNYAFNKGIKSIYYIR
TFTDDGEEVGANQCESCVI
>M5005_Spy0347 nrdF.1, ribonucleoside-diphosphate reductase beta chain
MTQHYYERSQSPIEYALSETQKQLRSINWNYLNDDKDLEVWNRVTQNFWL
PEKVPVSNDLNSWRSLGEDWQQLITRTYTGLTLLDTVQATVGDVAQIQHS
QTDHEQVIYTNFAFMVGIHARSYGTIFSTLCSSEQIEEAHEWVVSTQSLQ
DRARVLIPYYTGDDPLKSKVAAAMMPGFLLYGGFYLPFYLSARGKMPNTS
DIIRLILRDKVIHNYYSGYKYQQKVARLSPEKQAEMKAFVFDLLYELIDL
EKAYLRELYAGFDLAEDAIRFSLYNAGKFLQNLGYESPFTDEETRVSPEV
FAQLSARADENHDFFSGNGSSYVMGITEETTDDDWEF
>M5005_Spy1124 nrdF.2, ribonucleoside-diphosphate reductase beta chain
MTTYYEAINWNEIEDVIDKSTWEKLTEQFWLDTRIPLSNDLDDWRKLSLQ
EKDLVGKVFGGLTLLDTMQSETGVEAIRADVRTPHEEAVLNNIQFMESVH
AKSYSSIFSTLNTKKEIEEIFEWTNNNEFLQEKARIINDIYANGDALQKK
VASTYLETFLFYSGFFTPLYYLGNNKLANVAEIIKLIIRDESVHGTYIGY
KFQLGFNELPEDEQENFRDWMYDLLYQLYENEEKYTKTLYDGVGWTEEVM
TFLRYNANKALMNLGQDPLFPDTANDVNPIVMNGISTGTSNHDFFSQVGN
GYLLGSVEAMSDDDYNYGL
>M5005_Spy0348 nrdI, hypothetical protein
MAELIIVYFSSKSNNTHRFVQKLGLPAQRIPVDNRPLEVSTHYLLIVPTY
AAGGSDAKGAVSKQVIRFLNNPNNRKHCKGVISSGNTNFGDTFALAGPII
SQKLQVPLLHQFELLGTATDVKKVQAIFARLKHHTHDKQKQTNNLITERT
HPCHKPMRHTSH
>M5005_Spy1586 nupC, nucleoside permease
MQFIYSIIGILLVLGIVYAISFNRKSVSLSLIGKALIVQFIIALILVRIP
LGQQIVSVVSTGVTSVINCGQAGLNFVFGSLADSGAKTGFIFAIQTLGNI
VFLSALVSLLYYVGILGFVVKWIGKGVGKIMKSSEVESFVAVANMFLGQT
DSPILVSKYLGRMTDSEIMVVLVSGMGSMSVSILGGYIALGIPMEYLLIA
STMVPIGSILIAKILLPQTEPVQKIDDIKMDNKGNNANVIDAIAEGASTG
AQMAFSIGASLIAFVGLVSLINMMLSGLGIRLEQIFSYVFAPFGFLMGFD
HKNILLEGNLLGSKLILNEFVSFQQLGHLIKSLDYRTALVATISLCGFAN
LSSLGICVSGIAVLCPEKRSTLARLVFRAMIGGIAVSMLSAFIVGIVTLF
>M5005_Spy0365 pfs, 5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase
MKIGIIAAMEEELSLLLANLLDAQEHQVLSKTYYTGRFGKHELILVQSGV
GKVMSAMTVAILVEHFKAQAIINTGSAGAVASHLAIGDVVVADRLVYHDV
DATAFGYAYGQMAGQPLYYDCDPQFVAIFKQVLKHEKTNGQVGLIATGDS
FVAGQDKIDQIKTAFSDVLAVEMEGAAIAQAAHTAGKPFIVVRAMSDTAA
HDANITFDQFIIEAGKRSAQTLMTFLENLPV
>M5005_Spy0018 prsA.2, ribose-phosphate pyrophosphokinase
MSYSDLKLFALSSNKELAEKVASAMGIQLGKSTVRQFSDGEIQVNIEESI
RGHHVFILQSTSSPVNDNLMEILIMVDALKRASAEKISVVMPYYGYARQD
RKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGA
PLIADYFDRHGLVGEDVVVVSPDHGGVTRARKLAQFLQTPIAIIDKRRSV
DKMNTSEVMNIIGNVSGKKCILIDDMIDTAGTICHAADALAEAGATAVYA
SCTHPVLSGPALDNIQRSAIEKLIVLDTIYLPKERLIDKIEQISIADLVA
EAIIRIHEKRPLSPLFEMGN
>M5005_Spy0698 punA, purine nucleoside phosphorylase
MSLMTKINETKDFLVTKGIETPEFGLILGSGLGELAEEVENAIVIDYADI
PNWGKSTVVGHAGKLVYGDLAGRKVLALQGRFHFYEGNPLEVVTFPVRVM
KALGCEGVLVTNAAGGIGYGPGTLMAITDHINMTGNNPLIGENLDEFGPR
FPDMSDAYTKVYRNKAHEVAEKMNIKLEDGVYMGLTGPTYETPAEIRAFK
VLGADAVGMSTVPEVIVAAHSGLKVLGISAITNFAAGFQSELNHEEVVEV
TQHIKEDFKGLVKAILAEL
>M5005_Spy0136 purA, adenylosuccinate synthetase
MTSVVVVGTQWGDEGKGKITDFLSADAEVIARYQGGDNAGHTIVIDGKKF
KLHLIPSGIFFPQKISVIGNGVVVNPKSLVKELAYLHDEGVTTDNLRISD
RAHVILPYHIQLDQLQEDAKGDNKIGTTIKGIGPAYMDKAARVGIRIADL
LDKDIFAERLRINLAEKNRLFEKMYDSTPLGFDAIFEEYYAYGQEIKQYV
TDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIG
SGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDEVGERIREVGHEYGTTT
GRPRRVGWFDSVVMRHSRRVSGITNLSLNSIDVLSGLDTVKICVAYDLDG
KRIDYYPASLEQLKRCKPIYEELPGWQEDITGVRSLDELPENARNYVRRV
GELVGVRISTFSVGPGREQTNILESVWASI
>M5005_Spy0033 purB, adenylosuccinate lyase
MLERYSRPEMAAIWTEENKYHAWLEVEILADEAWAELGEIPKEDVAKIRE
KADFDIDRILEIEQDTRHDVVAFTRAVSETLGEERKWVHYGLTSTDVVDT
AYGYLYKQANDIIRRDLENFTNIVADKAREHKMTIMMGRTHGVHAEPTTF
GLKLATWYSEMKRNIERFEHAAAGVEAGKISGAVGNFANIPPFVEEYVCD
KLGIRPQEISTQVLPRDLHAEYFAVLASIATSIERMATEIRGLQKSEQRE
VEEFFAKGQKGSSAMPHKRNPIGSENMTGLARVIRGHMVTAYENVSLWHE
RDISHSSAERIITPDTTILIDYMLNRFGNIVKNLTVFPENMMRNMESTFG
LIYSQRVMLKLIEKGMTREEAYDLVQPKTAYSWDNQVDFKPLLEEDTKVT
SCLTQEEIDELFNPIYYTKRVDDIFKRLGI
>M5005_Spy0029 purD, phosphoribosylamine--glycine ligase
MFQLLITNTLCKKANVYDIISNYNTKEVDVLKLLVVGSGGREHAIAKKLL
ASKGVDQVFVAPGNDGMTLDGLDLVNIVVSEHSRLIAFAKENEISWAFIG
PDDALAAGIVDDFNSAGLRAFGPTKAAAELEWSKDFAKEIMVKYNVPTAA
YGTFSDFEKAKAYIEEQGAPIVVKADGLALGKGVVVAETVEQAVEAAQEM
LLDNKFGDSGARVVIEEFLDGEEFSLFAFANGDKFYIMPTAQDHKRAFDG
DKGPNTGGMGAYAPVPHLPQSVVDTAVEMIVRPVLEGMVAEGRPYLGVLY
VGLILTADGPKVIEFNSRFGDPETQIILPRLTSDFAQNIDDIMMGIEPYI
TWQKDGVTLGVVVASEGYPFDYEKGVPLPEKTDGDIITYYAGVKFSENSE
LLLSNGGRVYMLVTTEDSVKAGQDKIYTQLAQQDTTGLFYRNDIGSKAIR
E
>M5005_Spy0030 purE, phosphoribosylaminoimidazole carboxylase catalytic subunit
MLKHLVALTWVRLRNQRFRTYLIFFYGKFRQVETPLCILIMKTPIISIIM
GSKSDWATMQKTAEVLDNFGIAYEKKVVSAHRTPDLMFKHAEEARGRGIK
IIIAGAGGAAHLPGMVAAKTTLPVIGVPVKSRALSGLDLLYSIVQMPGGV
PVATMAIGEAGATNAALTALRILSIEDQNLADALAHFHEEQGKIAEESSG
ELI
>M5005_Spy0024 purF, amidophosphoribosyltransferase
MTYEVKSLNEECGVFGIWGHPQAAQVTYFGLHSLQHRGQEGAGIVSNDNG
KLYGYRNVGLLSEVFKNQSELDNLTGNAAIGHVRYATAGSADIRNIQPFL
YKFHDGQFALCHNGNLTNAISLRKELEKQGAIFNASSDTEILMHLIRRSH
NSSFMGKVKEALNTVKGGFAYLLMTENKLIAALDPNAFRPLSIGQMQNGA
WVISSETCAFEVVGAKWVRDVEPGEVILIDDRGIQCDRYTDETQLAICSM
EYVYFARPDSTIHGVNVHTARKNMGKRLAQEFKQDADIVIGVPNSSLSAA
MGFAEESGLPNEMGLVKNQYTQRTFIQPTQELREQGVRMKLSAVSGVVKG
KRVVMIDDSIVRGTTSRRIVGLLREAGASEVHVAIASPELKYPCFYGIDI
QTRRELISANHSVDEVCDIIGADSLTYLSLDGLIESIGLETKAPNGGLCV
AYFDGHYPTPLYDYEEEYLRSLEEKTSFYIQKVK
>M5005_Spy0031 purK, phosphoribosylaminoimidazole carboxylase ATPase subunit
MVNSFKTIGIIGGGQLGQMMAIAAIYMGHKVITLDPASDSPASRVSEVIV
APYDDVEALGQLAARCDVLTYEFENVDADGLDAVVSACQLPQGTDLLRIS
QNRIVEKDFLANKAGVTVAPYKVVTSSLDLGGLDLTKTYVLKTETGGYDG
HGQKIIRSAEDLPEAQQLANSAQCVLEEFVNFDLEISVIVSGNGKDVTVF
PVQENIHRNNILSKTIVPARISDQLADKAKKTAVQIAKKLQLSGTLCVEM
FTTADDIIVNEIAPRPHNSGRYSIEACDFSQFDTHILGVLGAPLPQIQLH
APAVMLNVLGQHVQQATDYVAKNPSAHLHMYGKLEAKHNRKMGHVTVFAK
DADEVKEF
>M5005_Spy0025 purM, phosphoribosylformylglycinamidine cyclo-ligase
MSEKNAYAKSGVDVEAGYEVVERIKKHVARTERAGVMGALGGFGGMFDLS
KTGVKEPVLVSGTDGVGTKLMLAIKYDKHDTIGQDCVAMCVNDIIAAGAE
PLYFLDYIATGKNNPVKLEEVVSGVAEGCVQAGAALIGGETAEMPGMYGQ
DDYDLAGFAVGVAEKSQIIDGSKVKEGDILLGLASSGIHSNGYSLVRRVF
ADYTGKELLPELEGKQLKDVLLEPTRIYVKAALPLIKEELVKGIGHITGG
GFIENIPRMFADDLAAEIDEDKVPVLPIFKALEKYGDIKHEEMFEIFNMG
VGLMLAVSPENVNRVKELLDEPVYEIGRIIKKADASVVIK
>M5005_Spy0026 purN, phosphoribosylglycinamide formyltransferase
MKIAVFASGNGSNFQVIAEQFPVSFVFSDHRDAYVLERAQNLAIPSFAFE
LKEFENKVAYEQAIVDLLDKHEIDLVCLAGYMKIVGETLLLAYERRIINI
HPAYLPEFPGAHGIEDAWEAGVDQSGVTIHWVDSGVDTGQVIQQVRVPRL
ADDSLESFETRIHETEYQLYPAVLDSLGVERKVI
>M5005_Spy0228 purR, pur operon repressor
MKLRRSERMVVISNYLINNPYKLTSLNTFATKYEAAKSSISEDIAIIKKA
FEEANIGDIDTLTGASGGVIFTPSISETEARTIVEDLCQRLSESDRILPG
GYIYLSDLLSTPKILQNIGRIIANAFKGEKIDAVMTVATKGVPLANAVAN
ILSVPFVIVRRDLKITEGSTVSVNYASASSDRIEKMFLSKRSLKPNSRVL
IVDDFLKGGGTITGMISLLTEFDSTLVGVAVFAENAQSEREQMTFKSLLK
VSEIDVKNNNVVVEVGNIFDKWKKEREWT
>M5005_Spy0641 pyrB, aspartate carbamoyltransferase
MSVVNNRVALTNLVSMEALTTEEVLGLINRGSEYKAGKVVISDHQKDLVA
NLFFENSTRTHKSFEVAEKKLGLTVLDFNADASAVNKGESLYDTVLTMSA
LGTDICVIRHPEDDYYKELVESPTITASIVNGGDGSGQHPSQCLLDLLTI
YEEFGRFEGLKIAIAGDLTHSRVAKSNMQILKRLGAELYFYGPEEWYSEA
FNAYGTYIAIDQIIKELDVLMLLRVQHERHDGHQSFSKEGYHQAFGLTQE
RYQQLKDSAIIMHPAPVNRDVEIADSLVEAPKARIVSQMANGVFVRMAII
EAILNGRNKNS
>M5005_Spy0709 pyrC, dihydroorotase
MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLI
VAPGLVDIHVHFREPGQTHKEDIHTGALAAAAGGVTTVVMMANTNPVISD
VETLQEVLASAAKEKIHIYTNASVTQAFNGKDVTDFKALLEAGAVSFSDD
GIPLESSKVLKEAFDLANANQTFISLHEEDPQLNGVLGFNEGIAEEHFHF
CGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVVAFAQQLGAKV
TAEVSPQHFSTTEDLLLIAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVI
ATDHAPHHKDEKAVDDMTKAPSGMTGLETSLSLGLTHLVEPGHLTLMSLL
EKMTLNPALLYGFDAGYLAENGPADLVIFADKQERLITENFASKASNSPF
IGNKLKGVVKYTIADGEVVYPN
>M5005_Spy1165 pyrD, dihydroorotate dehydrogenase
MVSTATQIGHFSFDNCLMNAAGVYCMTKEELMEVEKSQAASFVTKTGTLE
VRPGNPEPRYADTRLGSINSMGLPNNGFRYYLDFVSDLAKTGQHKPHFLS
VVGLSPTETETILKAIMASDYEGLVELNLSCPNVPGKPQIAYDFETTDQL
LENIFTYYTKPLGIKLPPYFDIVHFDQAAAIFNKYPLSFVNCVNSIGNGL
VIKDEQVLIKPKNGFGGIGGDYIKPTALANVHAFYKRLKPSIHIIGTGGV
KTGRDAFEHILCGASMVQIGTALHQEGPAIFERVTKELKTIMVEKGYQSL
DDFRGNLRYKD
>M5005_Spy0704 pyrE, orotate phosphoribosyltransferase
MTLASQIATQLLDIKAVYLKPEDPFTWASGIKSPIYTDNRVTLSYPKTRD
LIENGFVETIKAHFPEVEVIAGTATAGIPHGAIIADKMTLPFAYIRSKPK
DHGAGNQIEGRVLKGQKMVIIEDLISTGGSVLDAAAAASREGADVLGVVA
IFTYELPKASQNFKEAGIKLITLSNYTELIAVAKLQGYITNDGLHLLKKF
KEDQVNWQQ
>M5005_Spy0703 pyrF, orotidine 5'-phosphate decarboxylase
MKEERPIIALDFSSFEETKAFLDLFPAEEKLYVKIGMELYYVQGPDIVRY
IKSLGHNVFLDLKLHDIPNTVRAAMAVLKELDIDMATVHAAGGVEMLKAA
REGLGQGPTLIAVTQLTSTSEDQMRGDQNIQTSLLESVLHYSKGAAKAQL
DGAVCSAQEVEAIKAVTPTGFTCLTPGIRPKGSNIGDQKRVMTPNQARRI
GSDYIVVGRPITQAKDPVAAYQAIKAEWAG
>M5005_Spy1610 pyrG, CTP synthase
MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGR
>M5005_Spy0378 pyrH, uridylate kinase
MLLVEAISDVESLQQTTGMDRVQADYTGMLGTVMNALVMADSLQHYGVDT
RVQTAIPMQNVAEPYIADVPCAI
>M5005_Spy0640 pyrP, uracil permease
MKDVIYDVEEVPKAGMLVGLSFQHLFAMFGATVLVPILVGIDPSVALLSS
GLGTLAHLSVTKFKIPAYMGSSFAYIAAMQLLMKTNGIGAVAQGAMTGGL
VYLIVALIVKAIGNDWIDNILPPIVVGPIVMVIGLSLASTAVNDVMLKNG
NYNLTYLVIGLVTLLSVIFFNIYGKGIVAIVPLLLGLLVGYVVALLVGVL
TGQEIVDFTNVAQAKWFSIPSVEIPFLTYGVKFYPSAILTMAPIAFVTMT
EHFGHIMVLNSLTKRDYFKDPGLEKTLTGDGFAQIIAGFLGAPPVTSYGE
NIGVMALNKIFSVYVIAGAAVIAALLSFIGKVSALIQSIPTPVIGGISVA
LFGVIASSGLKILIESKVDMDNKKNLLIASVILVSGIGGLMLQVNGLQIS
GVAFSTLLGIILYQVLPEK
>M5005_Spy0639 pyrR, pyrR bifunctional protein
MKTKEIVDDVTMKRAITRITYEIIERNKQLDNVVLAGIKTRGVFLARRIQ
ERLHQLEGLDLPIGELDIKPFRDDMRVEEDTTLMSVDITGKDVILIDDVL
YTGRTIRAAIDNLVSLGRPARVSLAVLVDRGHRELPIRADYVGKNIPTSS
VEEIVVEVVEVDGRDRVSIIDPT
>M5005_Spy0925 rnhB, anaerobic ribonucleoside-triphosphate reductase
MKRDDLMQIIKRDGHVADFDPDKIYQAIIKAARTVYVIDDTWRQNLTHVT
KKVVIDLEEAHVERPTINMVQSLVENRLMDAGYITIAEHYISYRLQRDLE
RNGYGDKIVVHLRFEQIK
>M5005_Spy0862 tdk2, thymidine kinase
MAQLYYKYGTMNSGKTIEILKVAHNYEEQGKPVVIMTSALDTRDGFGIVS
SRIGMRREAIPISNDMDIFTFIAQLEEKPYCVLIDESQFLSKQNVYDLAR
VVDELNVPVMAFGLKNDFQNNLFEGSKHLLLLADKIDEIKTICQYCSKKA
TMVLRTENGKPVYEGDQIQIGGNETYIPVCRKHYFNPDI
>M5005_Spy0688 thyA, thymidylate synthase
MTKADQIFKANIQKIINEGSLSEQARPKYKDGRTAHSKYITGAFAEYDLA
KGEFPITTLRPIPIKSAIKELFWIYQDQSNSLDVLEAKYNVHYWNEWEVD
QTRTIGQRYGAVVKKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKG
LLPCAFQIMFDVRRVGEDLYLDASLTQRSNDILVAHHINAMQYVALQMMI
AKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLKRQPVASQPKLVLNVPDR
TNFFDIKPDDFELQNYDPVKPQLHFDLAI
>M5005_Spy0330 tmk, thymidylate kinase
MITGKLITVEGPDGAGKTTVLEQLIPLLKQKVAQDILTTREPGGVAISEH
IRELILDINHTAMDPKTELLLYIAARRQHLVEKVLPALEAGQLVFIDRFI
DSSVAYQGAGRGLIKADIQWLNEFATDGLEPDLTLYFDVPSEIGLARINA
NQQREVNRLDLETIEIHQRVRKGYLALAKEHPKRIVTIDATKPLKEVVSV
ALEHVLALLLA
>M5005_Spy1116 udk, uridine kinase
MLKKPIIIGVTGGSGGGKTSVSRAILDSFPNARIAMIQHDSYYKDQSHMS
FEERVKTNYDHPLAFDTDFMIQQLKELLAGRPVDIPIYDYKKHTRSNTTF
RQDPQDVIIVEGILVLEDERLRDLMDIKLFVDTDDDIRIIRRIKRDMMER
GRSLESIIDQYTSVVKPMYHQFIEPSKRYADIVIPEGVSNVVAIDVINSK
IASILGEV
>M5005_Spy1587 udp, uridine phosphorylase
MQNYSGEVGLQYHLQIRPGDVGRYVIMPGDPKRCAKIAEHFDNAVLVADS
REYVTYTGTLNGEKVSVTSTGIGGPSASIAMEELKLCGADTFIRVGTCGG
IDLDVKGGDIVIATGAIRMEGTSKEYAPIEFPAVADLEVTNALVNAAKKL
GYTSHAGVVQCKDAFYGQHEPERMPVSYELLNKWEAWKRLGTKASEMESA
ALFVAASHLGVRCGSDFLVVGNQERNALGMDNPMAHDTEAAIQVAVEALR
TLIENDKSQ
>M5005_Spy0327 upp, uracil phosphoribosyltransferase
MGKCQVISHPLIQHKLSILRRQTTSTKDFRELVNEIAMLMGYEVSRDLPL
EDVDIQTPVSKTVQKQLAGKKLAIVPILRAGIGMVDGLLSLVPAAKVGHI
GMYRNEETLEPVEYLVKLPEDINQRQIFLVDPMLATGGSAILAVDSLKKR
GAANIKFVCLVAAPEGVKKLQEAHPDIDIFTAALDDHLNEHGYIVPGLGD
AGDRLFGTK
>M5005_Spy0858 xpt, xanthine phosphoribosyltransferase
MQLLEERILTDGNILGENILKVDNFLTHQVDYRLMKAIGKVFAQKYAEAG
ITKVVTIEASGIAPAVYAAEAMDVPMIFAKKHKNITMTEGILTAEVYSFT
KQVTSTVSIAGKFLSKEDKVLIIDDFLANGQAAKGLIEIIGQAGAQVVGV
GIVIEKSFQDGRRLIEDMGIEVTSLARIKNFENGNLNFLEADA