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# Nitrosomonas europaea ATCC 19718, ATCC 19718

>NE0047 Cytidine and deoxycytidylate deaminase zinc-binding region
MNDALHIGLPPFLVQANNEPRVLAAPEARMGYVLELVRANIAADGGPFAA
AVFERDSGLLIAAGTNRVVPGRCSAAHAEILALSLAQAKLDTHDLSADGL
PACELVTSAEPCVMCFGAVIWSGVRSLVCAARSDDVEAIGFDEGPRPENW
MGGLEARGITVTTGLLRDAACALLREYNACNGVIYNARCGVHK
>NE1826 Phosphoribosyl transferase
MSYDSLMVFTGTANPKLAHDVVKYLNINLGRANVGRFSDGEVMVEILENV
RGNDVFVLQSTCTPTNDSLMEILVIVDALKRASASRVTAAIPYFGYARQD
RRTRSARVPITAKVVANMLTSVGVDRVLTMDLHSDQIQGFFDIPVDNVYG
MPILLGDIWKHDYQNLIVVSPDVGGVVRARHLAKRLECDLAIIDKRRPKP
NESKVMNIIGDVRGRTCVIIDDMVDTANTLCEAASALKREGAASVIAYST
HAVLSGKAVERVQTSDLDKLVVTDTIPLREDASKCNRIHQLSVASLLGES
MLRISNESSLSSLFIE
>NE0437 Cytidine and deoxycytidylate deaminase zinc-binding region
MKIQGVRVPVQTEDEYFMRQALDLARVAGAAGEVPVGAVMVRESRIVGCG
HNCPVTTVDPTAHAEIRALRDAASRVGNYRLPGCTLYVTLEPCVMCIGAM
FHARITRLVYAANDPKTGVCGSLLDLPADTRLNHHLMVSQGVLADEAGTL
LKQFFIAKRGIKERNTS
>NE0071 Deoxynucleoside kinase
MNLERCRYIVVEGPIGAGKTSLARNMATRLNYSLMLEQPEANPFLEKFYG
DMSRHTLSTQLFFLIQRMQQLQSMERENVFSRSVISDFLFEKDRLFADVT
LSEPEHGLYRQIREHMPLNAPRPDLVIYLQAAPEILIRRIRQRGNALEQR
ISEDYLRRLTERYMRFFYEYDQAPVMIVNSEHIDLAHNLADLDMLLARID
QMRSAREYFNVGAS
>NE0585 conserved hypothetical protein
MKPVAILRFFPIEGPGYFATFLNHHHIPWQLICLDEGTPPPKNMNKYSGL
VLMGGPMSVHDDLPWIGSVLSLIRQATSTDIPVLGHCLGGQLLSTALGGV
VTNNPIKELGWGRVDVTSSSIAHDWFGTDLTEFDAFHWHGETFSIPANAV
RLLSSPYCPNQAFALGIHLGLQCHIEMTAEMVKIWCEANAAELVQSRESP
AVSSSEEIQANLDDRIAALQSIADRLYKKWIKALKN
>NE1158 NUDIX hydrolase
MKFCSQCGGEVILRIPEGDTLPRYICPKCHTIHYQNPKVIVGCIPEWENK
VLLCKRAIAPYRGKWTLPAGFMENNETLVQGAARETLEEANARVEIRELY
AVYSLPHISQVYMLFRAKLLDLDFFPGIESLEVRLFGEQEIPWNDIAFRV
IHDPLKRYMEERHHGQPAFHLGIINKPQAGSNSNE
>NE1792 hypothetical protein
MKVLLLCESGPLGLKVLYCLKGMNAFVQTAGPRGARILKYSRYTDGHSEV
QFWQDGLPSVKTQQLLRERVQGENFDIILPSDMGSAAFLAATKKAYPDLP
CFPCSDQVILDTLHNKWSFAQTCAKYRLPIPPTILLTSSDQLDTSTLDPV
GFPLIVKPLEAESSHGVVRLDNLQALRTYIEQDSHYAQLPLIVQSYIPGR
DIDISILAANDRILCNTVQSWLEDGVLEFTQHPEMHAIATRLVQAFHYEG
LAHFDMRIDARDGKLYVIECNPRAWYTISASMWQGLNFIEMGIHYTKTGT
LPKISEKSGEGRYCLAGSLWKQLLLPHKGWKNLSVGSVRGFVQAITDPVP
HLYSKLT
>NE1951 Fumarate lyase:Adenylosuccinate lyase
MEISTLLALSPLDGRYQQKVAALRPFFSEYALIRNRIHVEIEWFKALGNT
PALTGASSLSTGAVVQLDQLVENFSVTDAEAVKSIETRTNHDVKAVEYWL
KEKLTGDQETAAISEFVHFACTSEDINNLSHGLMLKHSRDQVMLPALDEV
IKRLAVLARDLADLPMLARTHGQAATPTTMGKEMANFVYRLRGARERLAA
VVITGKINGAVGNYNAHMIAFPDFDWESFARSFVEKLGLSFNPYTTQIEP
HDTMAELFDAHVRINTILLDLNRDIWGYVSLGYFRQKTRADEVGSSTMPH
KVNPIDFENSEGNLGIANALLKHLSEKLPVSRWQRDLTDSTVLRNMGVAL
GHTLLAYDSCLKGLGKLQADPARLSEDLQNAWEVLAEPIQTVMRRYGVAN
PYEQLKALTRGKTGIDRTTLQQFIEQLDIPAAERDRLLQLTPWGYIGLAA
HLARDIGD
>NE0176 conserved hypothetical protein
MSVEIFNGTMQKFGAPDTVICQFQYWSVLLRPAQLTLGALVLVAHEPVQS
FSALSSTSFAELQIVTGKIDTALKKAFQYDKLNYLMLMMVDPDVHFHVIP
RYAQAREFAGKTFLDAGWPGVPDFSRINETDKEMNQQIIEHLISCWECS
>NE0623 dUTPase:dCTP Deaminase
MSIKSDKWIRRMAAEYNMIEPFEPNQIKQRNGESIVSYGTSSYGYDIRCS
DEFKLFTNLNSTIVDPKRFDSNSFVDVKGDICIIPPNSFALARTVEYFRI
PRNVLTICLGKSTYARCGIIVNVTPFEPEWEGYVTLEFSNTTPLPAKIYA
NEGVAQVIFFESDEVCETSYKDRNGKYQFQQGVTLPKI
>NE1167 Purine and other phosphorylases, family 1
MSRTGIVIAMRSEAACITSQRNLPFDQAVPIDDHLVIRMCGMGPVAARRA
AIDLYDQENVAGLISFGIAGALDDALQPGDLVSPESVQTKQSYSTDSAWR
TRIERSLPAHLNIIRRPVAASDELVSTADEKYALAARSGACAVDMESGAI
AAVASEKGVPFVVIRVISDPVQFSPPAALMDVLHPDGRVKPIALLAYLLN
GSLKLGELLRFGSDAQIAFKTLKQVVQATRHELGRQVSGTCQGISD
>NE0277 Ham1 family
MNKIVIASNNAGKLAEISRLLAPLGIEVVTQSSLGVTEADEPHMTFVENA
LAKARHASLATGLPALADDSGICVSALRGDPGVFSARYAGEPRSDERNNR
KLVEALHGQSDRRAYYYCVIVLLRHGQDPQPVIIEDTWRGEIIAEPIGQG
GFGYDPHFFLPELGKTAAELSIEEKNRISHRGKALARLVQMLSENETVPV
VPV
>NE1754 Purine and other phosphorylases family 2
MLAIIGGRSMNKLAGLEVTHRQVMRTPYGEPSGALIFGTIGTREIVFLSR
HGHGLTIPPHAVNYRANIWVLSTLKIKTIIAVASVGGIRKDMGPGKIVVP
DQIIDYTHSREATFHGRSNGTIIHTDFTQPYCSQTRTSLLQAARDAGESV
IDGGVYAATQGPRFETAAEINRLERDGADLVGMTGMPEAILARELGISYA
TIAAVANHAAGRGESIQAIPLQAAHLALENAMGSVRNILEHLVRNYDD
>NE1933 adk, Adenylate kinase
MPICLTRLLATAFHRLSAAHTTAGCSPSPTILKEANIRIILLGAPGAGKG
TQASFIRECFSIPQISTGDILRNAVKAGTELGMMAKKIMESGGLVPDEII
IDLVRKRIEEPDCANGFLFDGFPRTIPQADALRTANVHIDHVIEIDVPDA
EIIKRLSGRRVHPPSGRIYHIEFNPPAVADRDDVTGEALVLREDDREETV
RKRLQVYHEQTRPLVGYYFEWANSGDPNAPGYIKIAGTGNVEAIQENIIA
ALKQTK
>NE0181 apt, Phosphoribosyl transferase
MSIKSRIRTIPHYPHEGIMFRDITTLLKDPAGLRSTIDGIVQRYQTEKID
KVVGIESRGFIIAAPVAYALSAGFVPVRKQGKLPAETIGCDYQLEYGYDK
VEIHVDAIDKGDRVLLIDDLIATGGTMEAAIKLVQEAGGEVIECCFVIDL
PDIGGSRRLRQQGHRLFSLCSFED
>NE1662 carA, carA; carbamoyl-phosphate synthase (small chain) protein
MSNRPRAVLVLADGTVFHGDSIGAEGITIGEVAFNTAMTGYQEILTDPSY
CRQIVTLTYPHIGNTGVNDEDIESTTASRIIHAAGLVVRDLSLVTSSWRS
RHTLPDFLKQHGVPAIAGVDTRKLTRILRTKGAQAGCIMTGHIDETEALR
QAQAFPGLTGMDLARVVSCSQPWEFSEGAWSPETGYQAAGESRCRVAVLD
FGVKRAILRKLVEHGCHVTVYPAQTRIDEILAARPDGVLLSNGPGDPEAC
DYAIDMARALLASKIPVFGICLGHQIIALAIGARTIKMKFGHHGANHPVL
DVDSGRVMITSQNHGFAVDVDTLPANVRVTHHSLFDGSLQGFELTDHPVL
CFQGHPEASPGPQDVNYLFSRFISRIVKNKQSA
>NE1661 carB, Carbamoyl-phosphate synthase:Methylglyoxal synthase-like domain
MPKRTDLKSILIIGAGPIVIGQACEFDYSGVQACRALREEGYRVILINSN
PATIMTDPELTDATYIEPITWQAVEKIIEIERPDALLPTMGGQTALNCAL
DLVRHGVLEKYGVVLIGASREAIDKAEDREKFKQAMTRIGLQSARSAMAH
SMEEAMQAQAMIGYPAIIRPSFTLGGSGGGIAYNREEFIEICERGLEASP
TRELLIEESVIGWKEYEMEVIRDKQDNCIIVCAIENVDPMGVHTGDSITV
APAQTLTDKEYQRMRDASIAVLREIGVETGGSNVQFAINPENGNMLVIEM
NPRVSRSSALASKATGFPIAKVAAKLAIGYTLNELGNDIAGGIIPASFEP
TIDYVVTKVPRFAFEKFPQANDRLTTQMKSVGEVMAIGRTFQESLQKALR
GLESGVDGLDEKTTDIEIIKAELGHPGPERLWYIADAFRCNIPFDEIHAL
TRIDSWFLVQIEDLIRQEQALSERRLEILDRRELYHLKRCGFSDQRLAAL
LGTSQDKVRARRHEQGVRPVYKRVDTCAAEFDTHTAYMYSTYEEECESRP
TDNKKIMVLGGGPNRIGQGIEFDYCCVHAALALREDGYETIMVNCNPETV
STDYDVSDRLYFEPLTLEDVLEIAAVEKPAGVIVQYGGQTPLKLARALET
NGVPIIGTSPDMIDCAEDRERFQAMLQGLGLKQPSNFTARTAETALAAAD
KIGYPLVVRPSYVLGGRAMEIVHEARDLERYIQEAVKVSNDSPVLLDHYL
NNAIEVDVDAISDGKAVLIGGIMEHIEQAGVHSGDSACSLPPFSLSASLQ
EELRRQTEAMAYALNVNGLMNIQFAIQDDTVYVLEVNPRASRTAPFVSKA
TGLQLAKIAARCMVGRTLADQGVTKEVYPSHFSVKEAVFPFAKFSGVDTI
LGPEMKSTGEVMGVGKNFAEAFVKSQLAAGVQLPVSGNVLISVRDSDKLE
AVSIAIKLVELGFSLYATRGTARTLQQAGLPVIAVNKVAEGRPHIVDMIK
NGEIVLIINTVANKRSAVRDSYSIRRVALQARITYYTTIAGARAACAGMA
SRQELQVYRLQNLAI
>NE1963 cmk, Cytidylate kinase
MDKQNVPVITLDGPSASGKGTIARLVSQALGFHYLDSGALYRLVALAAMK
RNTDVSDEHSMVDIARHLNVSFRDSSIWLEGKDVSDEVRAEACGEYASRI
AQYSALRVELLGYQRDFRKSPGLVTDGRDMGSVIFPDATLKIYLTASEEE
RALRRHKQLMEKGINASIADLIQALRARDERDSSRSTSPLQQCEDACLLD
TTGLSIDQVVSRVLNMYAEARKA
>NE1982 dgt, HD domain:Metal dependent phosphohydrolase HD domain
MRSNLAPYAVSDTNSRGRRIHEELPAGRSQFQRDRDRVIHSTAFRRLEYK
TQVFVNHEGDLFRTRLTHSLEVAQIGRSIARNLNLNEELVEAITLSHDLG
HTPFGHAGQDALNDCMKTYGGFEHNLQSLRVVDVLEERYATFNGLNLCFE
TREGILKRVPKSKAAALDELGTRFLHGHSASLEAQLANLADEIAYNNHDV
DDGLRSGLITLAQLEEIEIFARHLHQVKQHYPDITGRRLIHETVRGMINT
LVVDLTVQSGTRIRDASPDSPDSVREKPVLIGFSDTIKRQQQELKRFLHK
NLYKHYQVMRMSNKARHTIEKLFTTFETEPALLPYEYQQKFQEYGHQAIA
DYIAGMTDRYAIREYQRLFAITEN
>NE1462 dut, dUTPase
MKQVDIKLLDPRLQDVFPGYATPGSAGLDLRACIDERMEIHPGETLLIPS
GIAIHLADPGFAAMVLPRSGLGHKHGIVLGNLVGLIDSDYQGQILVSCWN
RGQAGFTLDPMERIAQLVIVPVVQAGFNVVENFQPSQRGEQGFGSTGKC
>NE2254 gmk, Guanylate kinase
MSCLFVISAPSGAGKTSVIRTLLQTDINLTLSISYTTRPPRRDEKNGHDY
FFVDHATFKDMQARGEFLESAEVHGNLYGTSRKWIEETMAAEQDVLLEID
CQGAQQIRTVYPQAASIFILPPSMEALKQRLEQRGQDENKVIERRLAAAR
SEISHVNRFDYVVVNHELETAARDVASIVQAERLKTIRQLVRQRSLIAEF
S
>NE0094 guaA, guaA; GMP synthetase
MHSAILILDFGSQYTRLIARRIRETNVYCELHPFDVSPQFIREFAPIGII
LSGGPASTFTEDAPRVPQIVFELGVPVLGICYGMQAMAAQLGGEVEDAQT
REFGYAELLTAPCKLFHGIQDRINSDGKPALDVWMSHGDRVNKLPPGFTA
IASNAATPFAAMADETRNFYGVQFHPEVTHTRQGKAILDHFVHDICSAGY
DWNMPDYVEEAIGRIRARVGNDKVVLGLSGGVDSSVAAALIHRAIGDQLV
CVFVDNGLLRLNEAKQIMETFSRNLAVNVIYIDAGRQFLEQLKGITDPEQ
KRRTIGREFVEIFQQEAEKIENAKWLAQGTIYPDVIESAGSHTKKAGVIK
SHHNVGGLPETLHLKLLEPLRELFKDEVRELGLALGLPHDLVFRHPFPGP
GLGVRILGEVKYEYTELLRQADAIFIEELRNAGWYEKTSQAFAVFLPIKS
VGVMGDNRSYEYVVALRAVQTEDFMTAHWAELPYTLLSRISNRIINEIRG
INRVVYDISGKPPATIEWE
>NE0640 hitA, HIT (Histidine triad) family
MEDCLFCKIVRGEIPATKIHEDEDTLVFLDIHPAAPVHLLVVPKQHIGSL
SEVDASHQQLLGKMLWLAPRLAASQGCTDGFRTIINTGRVGGQEVFHLHL
HVIGGKDRLPAMVHHD
>NE0144 ndk, Nucleoside diphosphate kinase
MAVERTLSIIKPDAVAKNVIGQIYARFEAAGLKVVAARMAHLSRVEAENF
YAIHRERPFFKDLVEFMISGPVMIQVLEGENAIARNRELMGATDPRKAEK
GTIRADFAESIDANAVHGSDAPETAVVEIACFFPSLEIHSR
>NE2423 nrdA, Ribonucleotide reductase large subunit
MQLATDLPSSSPVQQKNFLEEMTDLPATRQNYSQYKIIRRNGAVVAFEPG
KISIALTKAFIAVRGGQSAASSSMREIVAQLTGEVVHALTRRRPEGGTFH
IEDIQDQVELALMRSGDHDIARAYVLYREERARERARQQSAQPASGQVAV
LHVVENGQKIPLDPAQLMARIESACQNLGNTVDAALIVKSMLKDLYDGVP
AEEVRKSAILSARALIEKEPAYSFVTARLLLDNIRYEVLGEEVAHEAMQS
RYAEYFPEFVRKGIEAGLLDERLGQFDLARLSEALAADRDLQFGYLGLQT
LYDRYFLHVSERRIELPQIFFMRVAMGLALNEIDREARAIEFYHLLSKFD
FMSSTPTLFNSGTRRSQLSSCYLSTVPDSLDGIYEAIKENALLSKFAGGL
GNDWTPVRAMGARIKGTNGKSQGVVPFLKVVSDTAVAVNQGGKRKGAVCA
YLETWHLDIEEFLELRKNTGDDRRRTHDMNTAVWVPDLFMKRMQEDQEWT
LFSPSDTPDLHDKFGRAFEEAYIAYEEQAAQGRLTLFKRIPARQLWRKML
TMLFETGHPWITFKDPCNIRSPQNHVGVVHSSNLCTEITLNTSEKEIAVC
NLGSVNLLAHIVDGKLDQARLKQTVTTAMRMLDNVIDINFYAVAKARNAN
FRHRPVGLGIMGFQDCLHKLGISYASPEAVEFADRSMEAVAYHTYWASTE
LAEERGTYATYRGSLWDRGILPQDTLELLREERGGHVEIDTSSTQDWDAL
RDRIRQYGMRNSNCLAIAPTATISNIIGVSASIEPTYQNLYVKSNLSGEF
TVVNQWLVNDLKKQDLWDEVMIADLKHYDGAVSKIDRVPENLRNLYATAF
EVDPRWLVEAASRRQKWIDQAQSLNLYMAGASGKKMDELYRLAWLRGLKT
TYYLRALGATTAEKSTVHTGTLNAVPAQHEAHAGNLAHSAPQQCAIDNPE
CEACQ
>NE2422 nrdB, Ribonucleotide reductase
MLTFEDEVFQPGNILAGTSAQAGMANKMIAERQVLDEEIPAEDHRRVSVE
DKRIINCKADVNQLVPFKYKWAWEKYLSACANHWMPQEINMTRDIALWKD
PNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHITNPECRQYLLRQ
AFEEAIHTHAYQYIVESIGLDEGEIFNAYHEIGSIRDKDEFLIPFIDTLT
DPSFRTGTLETDQQLLKSLIVFACIMEGLFFYVGFVQILALGRQNKMTGA
AEQYQYILRDESMHCNFGIDVINQIKLENPHLWTREFREEISALMRKAVE
LEYRYAEDTMPRGVLGLNAPMFKEYLRFIINRRSHQIGLDPLFPEAGNPF
PWMSEMIDLKKEKNFFETRVIEYQTGGVLSWD
>NE1745 ppx, Ppx/GppA phosphatase
MHEYSTLAAVDLGSNSFHLQVARIAEKQLYLLDSLKEMVQLAAGLSDDQI
LDEASQNRALACLERFGQRLRGFPHHAVRVVGTNSLRVARNAADFLRKAE
NALGFPIEIIAGHEEARLIYLGVVHSLPISDNHLLVVDIGGGSTELIIGN
RLKSNKLESLPVGCINHSLHFFPDGKITKGSLKQAELAARTEIQAIAAEF
SSSHWQKAYGSSGTARALAHILTLNGYNNGNNEEVITLAGLEKLREFLLK
TGDIKKLEITGLNPARKAIIAGGFAIMSAVFTELNIDHMAIATGALREGV
LYDMLGRFHKEDTREISVQEFMQRYRVDPVQAARIESLAVTLGKQLLADH
PDTEKVEDALKLLSWAARLHEIGISVAHTGYHKHSAYILDNADIPGFSKM
EQSQLSQLVLSHHGSLVKTRDFLSQPVNFARSIALRIATIFYRSRTHINL
PDMTLSMNGKRCTLLIPQAWLERNPLTGTLLNNETETWAKVDIDFRIENR
VDGRRTKSGAA
>NE1281 purA, Adenylosuccinate synthetase
MARNVVVIGTQWGDEGKGKIVDWLTDRATGVVRFQGGHNAGHTLVVGGEK
TVLHLIPSGILRENVTCYIGNGVVLSPGALLEEVDMLEQAGVDVSGRLRI
SETCPLILPYHIAVDGARELAKGMEKIGTTGRGIGPAYEDKVARRAIRLQ
DLFRPERLACKLKEVLDYHNFLLKNYYHAATVDYHQVLDDCQIKAERIRP
MVADVPKLLFEASQADNNLLFEGAQGALLDIDHGTYPFVTSSNCIAGAAS
VGSGVGPQMLNYVLGITKAYTTRVGSGPFPTELSDATGEHLAQRGNEFGS
TTGRPRRCGWFDAVAARRSIQINGVSGLCITKLDVLDGLETLRIGVGYKS
KQSGEMYDALPFGADDLAAAEPVYEELPGWQERTAGIRNFDQLPQAAQNY
LKRMEEVCQTPISMISTGPDRTETIVFHHPFG
>NE0866 purC, SAICAR synthetase
MATAALFETSITSLPLLHRGKVRDIYAVDENHLLIIQTDRVSAFDVILPT
PIPEKGKILTKISRFWFDKLAHIIPNHLTDITPESVVSSREQDQVSDRAF
IVRKLKPLPVEAIVRGYISGSGWKDYQRSGTICGIALPAGLREADKIPDG
AIFTPSTKAEAGSHDENISYSVCEQLLGVSLAAAVSRHSIALYTAAADYA
LTRSIIIADTKFEFGLDEANQLYLIDEALTPDSSRFWPAESYRPGKTPPS
YDKQFIRDWLEQINWNKTPPAPPIPEEVLVQTIEKYQAACRVLTQ
>NE0877 purD, Phosphoribosylglycinamide synthetase
MRLLVIGSGGREHAIAWKLSQSPLIEKIFVAPGNAGTVLEAKLENVPMTS
IPDLVTFARQEKIDLTVVGPEVPLTEGIVDTFQASGLRIFGPTRKGARLE
GSKSFAKAFMLSHGIPTAACETFDDAAAAHRYIDQHSLPVVIKADGLAAG
KGVVVAQTLSEAHAAVDAMLVDNRLGTAGAHILIEDYLEGEEASFIVLSD
GKNVLPLATSQDHKRLRDNDEGPNTGGMGAYSPAPVITPELHDRIMQKVI
MPVIQGMTQQSQPYVGFLYAGLMISPQGEVRVLEFNCRLGDPETQTIMLR
LKSDLFILLEHAVDGTLDQTNIEWDQRVALCVVMAAQGYPDNPRKNDIIH
GLDSVMAAQHHSDEFHIFHAGTALNSTDSTEILTFGGRVLGVTALGGDIR
QAQSRAYAIAADIHFDGCQMRRDIGSRGLAQGSGGKPG
>NE0868 purE, purE; phosphoribosylaminoimidazole carboxylase catalytic subunit protein
MDHPVVSIVMGSSSDWQVMRHAASVLKNFCIPHETMIISAHRTPDRMFEY
AETAHDRGIRCIIAGAGGAAHLPGMIAAKTTLPVLGVPVTSKHLQGVDSL
LSIVQMPKGVPVATFAIGEAGAANAALFAAAILAGGDISLAEKLDQFRKD
QAASVAAMTLPESCT
>NE0699 purF, Glutamine amidotransferase class-II:Phosphoribosyl transferase
MCGILGVVARSPANQLLYDGLLMLQHRGQDAAGIVTAQGNSFHMHKGLGL
VRDVFRTRDMRALPGYMGIGHVRYPTAGSSTSPAEAQPFYVNSPFGIVLA
HNGNLTNAETLNQELFLADRRHVNTHSDSEVLLNVLAHELQERAVGYQLD
LAEIFSAVAGVHERCQGAYAVIAMIAGYGLLAFRDPYGIRPLVFGSVETD
AGTEYMVASESVALDTLGFRLIRDVAPGEAIFIDMEGHFYSHQCAALPSL
NPCIFEYVYLARPDSMLDGISVYETRLNMGINLADKISTSMQHLDIDVVI
PIPESSRPSAMQLANRLGISFREGFVKNRYVGRTFIMPGQQQRRKSVRQK
LNAIEIEFRGKNILLVDDSIVRGTTSREIVQMAREAGANKVYFASAAPPV
RFPNVYGIDMPTRQELIATDRTDEEICREIGADYLVYQNLDALRQAITQI
DPQIRHFETSCFDGRYIAGNITQEYLCRIESQRNNPGLSQGERTTQLDLA
LLSTD
>NE0876 purH, probable phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclodydrolase transmembrane protein
MSIKQALISVSDKTGIVELAAALHQFNITILSTGGTARLLQESGIPVIEV
SDYTGFPEMLDGRVKTLHPKVHAGILARMDLPEHRQVMEQAQIPAIDLVV
VNLYPFTQTITRPDCSFEEAIENIDIGGPTMIRAAAKNFQRVAVVTDPQD
YGPLLEQIRANDGSIDHDYRFQLAQKAFSHTARYDGAISNYLTALEPLSS
QRKRFPDQLNLSFTLAQPLRYGENPHQQAAFYRDTTNVPGSLADYDQLQG
KELSYNNIADTDAAWACVRTFDKPACVIIKHANPCGVAIADTALAAYKKA
FTTDPVSAFGGIIAINRAVEADLAKAVLQQFVEVIIAPEFSPEARHLLAD
KPNIRVLTVPLDKHNNVYDLKRVDGGLLVQTPDDLDITVDQLQVVTRIKP
TREQIEDCLFAWRVAKFVKSNTIVFCANGQTLGIGAGQMSRVDSARIASI
KAQQANLDLHGSVVASDAFFPFRDGLDVLAQAGAGVVIQPGGSIRDEEVI
AAADEQGVAMVFTGVRHFRH
>NE0867 purK, phosphoribosylaminoimidazole carboxylase, ATPase subunit; ATP-grasp domain
MYIKPGSMLGLLGGGQLGRMFAMAAQQMGYRVTVLDPAAESPAGSIAERH
LQADYLNDQALDELGSTCAAVTIEFENVPAQALRYLARRCVVSPDAESVS
IAQNRIREKQFLAENGFPVGPFTVVHDGQDLPRIDVSLFPGILKSSQSGY
DGKGQMRIEHADILSEALTALGNKPCVLEKRLSLAHEISVVLARDNLDQI
TFFPVPENHHERGILDTSIIPATLSDEIVGKARAVARQVATRLNYVGILC
VEFFVLGDGQILVNEIAPRPHNSGHYSLNACVTSQFEQQVRMLCGLPHGS
TKLVQEAAVMTNILGDLWKNGEPDWNSILQHPQTKLHLYGKRAAKPGRKM
GHFTVLADTVEEALQQTARIRQDLQF
>NE0019 purL, AIR synthase related protein
MLQFCGRNALSPFRLERLLHSIQAIVPQISGITANYRYFCQVQRDLTQEE
TNRLRQLLDVDETEAQPFPDSKLLLVVPRPGTISPWSSKATDIAHCCGLN
GIERLERGISFELRCQVTLLPAQLSRIEACIHDRMTEVVLHSLAEATLLF
HHSEPGMLNEIDLTGRGIDALLQANREMGLALSSDEIDYLLDYFTRIQRD
PTDVELMMFAQANSEHCRHKIFNADWIIDGVQQPHSLFGMIRHTHQSHPQ
HTIVAYSDNAAILEGEIIERFYPGKNDQYGYAPELTHWLAKVETHNHPTA
ISPFPGAATGVGGEIRDEGATGSGAKPKAGLTGFSVSNLRIPEAIQPWET
NAYGKPGHIASALDIMLTAPIGGAAFNNEFGRPNLAGYFRTYEVEINGRM
RGYHKPIMLAGGIGQISALHTAKEPFPEGTLLIHLGGPGMAIGLGGGAAS
SMDAGTNEEALDFNSVQRGNAEIQRRAQEVIDRCWQLARSGQPNPILAIH
DVGAGGLSNALPELVHDAGRGGRFDLRAVPSDEPGMSPMQIWCNEAQERY
VLAIRPESLSLFQAICERERCPFAVVGEALAELQLIVTDERSSTHPADMP
LPVLLGKPPKMVRDVKRIHPDPALLDKTGMQLQEAARRVLRLPAVANKSF
LITIGDRSVGGQTARDQMVGPWQVPVADVAVTTMGFQTYSGEAFALGERT
PLAVINAASSARMAVGEAVTNLAAAAIAGLGTVRLSANWMAAAGHPGEDV
ALYDAVHAVAMELCPALGISIPVGKDSLSMKTAWHDDQPKEVVAPLSLII
SAFATVSDVRKTLTPQLRTDKGETKLILIDLGNGKNRLGGSALAQVYTQS
GDDTPDLESPEKLNAFFDAIQTLNGSGLLLAYHDRSDGGLFVTLCEMAFA
GHCGITLALDSLISLSAEPDDDRDGQVLSTLFNEELGAVIQIEARHHDAV
MTILADAGLGHISHTIGSPNRQDDITLMVDGGIVFQEKCVALQRIWSETS
FRMQKLRDHPECAQQEFDQILDVDDPGLHAQLTFSLTESVASAPAILASR
PAVAILREQGVNGHVEMAAAFDRAGFDAVDVHMSDILSGRVKLAEYKGLI
AGGGFSYGDVLGAGRGWAQSILFNARARDEFATFFARTDTFALGVCNGCQ
MMSHLQAIIPGTAHWPRFGRNRSEQFEARFVMVRIGTSPSLFFDGMAGSR
LPVTVAHGEGLAVFRDAEQLLAAHPYVALQFVDNRGTLTETYPLNPNGSP
AGITGMTSADGRVTILMPHPERVFRTVQHSWHPDDWPEDSPWMKMFRNAR
KWVD
>NE0088 purM, purM; phosphoribosylformylglycinamidine cyclo-ligase (airS) protein
MTASNPANPDKNPISYRSSGVDIDAGNRLVERIKPFARRTMRPEALGGIG
GFGALFEVPGKYRQPVLVSGTDGVGTKLKLAFQYARHATIGIDLVAMSVN
DILVQGAEPLFFLDYFACGKLDVEIATQVVQGIAHGCEDAGCALIGGETA
EMPGMYPEGEYDLAGFAVGVVEKDRIIDGSGIRENDIVLGIASSGPHSNG
FSLIRKILDLNTVQSDTRLGETSLIDALLTPTRIYVKSLLTLMAELPVKG
LAHITGGGLLENIPRVLPDGVMAHIDSSTWVRPSLFDWLQQHGNVAREEM
LRVFNCGIGMVVVIAPEHAQTAIEILHNAGETVWQIGEIRPRQSETLPIV
IA
>NE0087 purN, purN; phosphoribosylglycinamide formyltransferase protein
MKSVVILISGRGSNMQAILEAGLPVAAVISNNPAAEGLMFAQTRGIPTQV
IDHRTFPDRKAFDAALAETIDTYQPDLVVLAGFMRILSEAFVDHYQGRLV
NIHPSLLPAFPGLDTHTRALQEGVKIHGCTVHFVTSQLDHGPIIAQAAIP
VLTDDTPTMLATRVLAQEHRIYPQAVRWFLQGQLTLVENRVEIKTTSDSQ
EVLYSPGIEP
>NE1665 pyrB, pyrB; aspartate carbamoyltransferase (catalytic chain) protein
MGVHPQLNKNGELQHLLTTEGLPAVILRHILDTAESFTGVTERDVKKIPL
LRGKSVFNLFFEPSTRTRTTFEIAAKRLSADVINLNMAVSSQTKGETLLD
TVDNLSAMHADMFIVRHNQSGAAHLIARHVRPEIHVINAGDGWHAHPTQA
LLDMFTIRRYKQDFHALRVAIIGDILHSRVARSQIHALTTLGVPEIRVIA
PKTLLPAKVERLGVHVYHNMVQGLQDVDVLMMLRLQHERMESAHLPSTEE
YFKYYGLTPEKLALARSDAIVMHPGPMNRGVEIDSEVADGTQSVILPQVN
FGIAVRMAVMSILAGN
>NE0727 pyrC, Dihydroorotase homodimeric type
MNDTADKLTFTRPDDWHLHLRDGNAMRSVLPDTARRFARAIIMPNLKPPI
VTTEQAAAYRVRILSALPAELAGRFEPLMTLYLTDTTSPEEITRAQASGI
VQGIKLYPAGATTHSDAGVTDIARCEATLEKMEELDMPLLVHGEVVDPAV
DVFDREKIFIDRVLTPLLQRFPGLRVVFEHITTREAVEFVQTAPNRIAAT
ITAHHLMLNRNALFTGGLRPHHYCLPVLKREIHRQALLEAATSGHSRFFL
GTDSAPHPVRDKESACGCAGIYSAHAAIEFYAEVFEQAGRLDRLEAFTSF
HGPDFYGLPRNTDRISLIRESWQIPEQVELGEEKLIPLRAGEHARWKLA
>NE2221 pyrD, pyrD; dihydroorotate dehydrogenase oxidoreductase protein
MMYNLLRPLLFLLDPETAHTVTLDTLNLLKRTGLLPDRTIDCTPVRVMEL
DFPNPVGLAAGLDKNGTCISALASLGFGFIEVGTITPRPQVGNPRPRLFR
IPQAEAIINRMGFNNVGVDKLIENVQQSGYRGILGINIGKNADTPLQNAI
DDYLICLRKVYLHASYVTVNISSPNTQQLRQLQNETELEHLLGALKAEQT
RLSDLHGRYTPLAIKIAPDLESEQITVIASLLMKHRMDAVIATNTTTARE
GVEHLPRGNEKGGLSGAPLTERSTTVIRQLANHLQHAIPIIGAGGIMSAR
DAQLKIEAGASLVQIYSGLIYRGPDLVTKTVSLLCSRTTHAG
>NE1734 pyrE, Phosphoribosyl transferase:Orotate phosphoribosyltransferase
MSDFQWRFIDFALQYDVLRFGNFRTKAGRPSPYFFNAGLFNDGFALKQLG
QFYAQAILASGIRFDALFGPAYKGIPLVSTIAIALAEAGHNHPFSFNRKE
IKDHGEGGDIVGAPLAGRILIVDDVVSAGLSVGESITLIHAAGATPCGIM
VALDRMEKGKSECSTLQEIKNKYDIPVISLITLDDIIAYLHTRQDLVHHI
PAIETYRTFYGAKVPDTVNHTGRSTSV
>NE1959 pyrF, Orotidine 5'-phosphate decarboxylase
MNDPRIIVALDFPDQCTALNFAAGLDSTLCRVKVGKELFTLAGPQLVEKL
MKLGFDVFLDLKFHDIPNTVAAACSAASSLGVWMVNVHALGGSKMLLAAR
QALDGKRTRLIAVTLLTSLNQNDLSELGIADTPETMVQRLALLAQRCGLD
GVVCSALEAVSLREVTGEDFCLVTPGIRSFGDGNDDQARIATPAMAIRSG
ASYLVIGRPITRSPDPLGALRRFNDEVASVL
>NE1045 pyrG, Glutamine amidotransferase class-I:CTP synthase
MTKFVFVTGGVVSSLGKGIAAASLAALLETRGIRVTILKLDPYINVDPGT
MNPFQHGEVFVTDDGAETDLDLGHYERFISTKMTRQNNFTTGQIYESVIR
KERRGDYLGGTVQVIPHITDEIKLFIRNGVSDAQVAIVEIGGTVGDIESL
PFLEAIRQMSVQLPHHDTCFIHLTLLPYISSAGELKTKPTQHSVKELREI
GIQPDVLLCRSDRPLPLEERRKIALFTNVREESVISAIDVDNIYKIPALL
HEQMLDEIVCHRLDILARPANLTVWKKLVHALEHPEHEVSIALVGKYVDL
TESYKSLSEALIHAGIHTRCKINIHYIDSENIEQHGTGCLTNMDAILVPG
GFGKRGVEGKIMAISYARNHRIPYLGICLGMQLAVIEFSRNRLQLENAHS
TEFDPDTPYPVLGLITEWRDRCGRVEKRSAQTDLGGTMRLGGQECLLKPH
TLAHKIYGADKVIERHRHRYEVNAEFIPQLEQAGMHISGLSAEGDLCEMI
ELPQSEHPWFVACQFHPEFTSTPRNGHPLFKSYIQAAISFAGQSDRTKLH
SRNVQESVTTDSSN
>NE1716 pyrH, Aspartokinase superfamily
MPVVYKRILLKLSGEALMGDGHYGIDRAVVEHIVVEVAGVLQLGVEVAIV
VGGGNIFRGMKSAGDGMDRVTADYMGMLATTMNALALHDAMRRNGVVSRV
QSALRIDQVVEPYVRGKALRYLDERKVVVFAAGTGNPFFTTDTAAALRGM
EMNANIVLKATKVDGIYTSDPLKNKDAQRFQSLTFDEAISKNLQVMDATA
LTLCRDQKLPINVFSIFKTGALKRVIMGEDEGTSVFV
>NE1666 pyrR, Phosphoribosyl transferase
MQLPDAEQLLTQLIEKIRPDIAGNTAIVGIHTGGAWLARRIHQALEIALP
VGVLDISFYRDDYSKIGLHPQVRPSQLPFDAENSHIILVDDVLYTGRTVR
AAVNELFDYGRPASIDLAVLVDRGGRELPIAARYTGEVLTLPENSMLELR
QSDDGKLSLDLRSLTTG
>NE1664 pyrX, Dihydroorotase:Dihydroorotase multifunctional complex type
MHIHIRNGRLIDPGSGMDRTDDLYLAEGKIVSIGSRPDGFHDDREIEAGG
MIVCPGLVDLSARLREPGLEYMATLESELEAAVAGGVTSLACPPDTDPPL
DEPGLVEMLKHRARNLDQARVYPVGALTQGLKGARLTEMVELHDAGCVAF
SQVDAPIANLHVLMRAMQYAATFGFKVWLRPQDIHLANHGVAHEGEIATR
LGLPAIPVCAETIALASILSLMKETGASVHLCRISSAEGTALVRAAKRQG
LPLTCDVSINHVHLTDMDIGFFDANCHLMPPLRSLADRDALCVGLMDGTI
DAICSDHAPVDEDAKSLPFAQAESGATGLELLLPLTLKWAVENRLSLPEA
LARITFHPARILGIETGQLAIGAVADLCIFDPDANWVVSHTELRSQGKNT
PFLGMELYGRTRFTLIGGRIVYG
>NE0568 thyB, Thymidylate synthase
MYQYLDLMRHVLQYGHKKSDRTGTGTLSVFGYQMRFDLQTGFPLVTTKKC
HVKSIIHELLWFLRGETNIDYLKRNGVSIWDEWADENGDLGPIYGHQWRS
WAASDGTVIDQISQVIQQIKETPDSRRMIVSAWNVGDLDKMKLAPCHVLF
QFYVADGRLSCQLYQRSADIFLGVPFNIASYSLLTLMIAQCCDLQPGEFV
HTFGDAHLYLNHLEQARLQLEREPRALPAMQLNSTVRNIFDFGYEDFTLH
DYDPYPPIKAPVAV
>NE2181 tmk, Thymidylate kinase
MQRGKFITVEGIDGAGKSTHLAWLERFLQDKGLEVVVTREPGGTALGEAL
RQLLLDHRQAMHPETEALLMFAARREHLDKVILPALDRGAWVVSDRFTDA
SFAYQGGGRGVAQSKLDNLEQWVQAELSPDLTVYFDVPVIVGRERLQSTR
VADRFEMESNLFFERVRQAYLQRAEQFPQRIRVVDGSRLLAEVKTAVAEI
VEDFWSDLSDTQFRG