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# Neisseria meningitidis MC58, MC58

>NMB0639 conserved hypothetical protein
MSEKPEKIVLASGNAGKLEEFGNLFKPYSITVLPQSAFGIPECPEPYPTF
VENALAKARHAAKYSGLPALADDSGICAAALNGAPGIHSARYAGDNPKSD
TANNLKLAAELVGKADKSCCYVCVLVFVRHKDDPRPIIAEGVWHGQWNDT
PLGQNGFGYDPYFYLPEHGKTAAELDTEVKNRESHRAQALAELLRKLAL
>NMB0849 putative deoxycytidine triphosphate deaminase
MSIKSDKWIRRMSEEFGMIDPFEPNQIKEADGKRIISYGTSSYGYDIRCA
NEFKIFTNINSTIVDPKNFDPKNFVTVEDDCCIIPPNSFALARTVEYFRI
PRNVLTVCLGKSTYARCGIIVNVTPFEPEWEGYVTLEFSNTTPLPAKIYA
GEGVAQVLFFESDEICETSYKDRNGKYMGQTGVTLPKA
>NMB1619 conserved hypothetical protein
MTAQPCPICTAQNEDVLLQTPNLRVIAVHNDSGSPAFCRVIWRKHIAEMT
DLSAAERGELMEMVYKVEAAMRQVFRPAKINLASLGNVVPHLHWHIIARF
ENDASFPAPIWANPVRKHGMTLPQDWTEQLKKLL
>NMB2047 putative hypoxanthine-guanine phosphoribosyltransferase
MTDLETKRLETQAMLENADLLFDQGQCRAALQKVADEITRDLGGKYPLLL
PVMGGAVVFTGQLLPLLRFPLDFDYVHVSRYGDKLEGGAFNWKRMPDAEQ
IRGRHVVVLDDILDEGHTMSAIQAKLLEMGAASCRAAVFANKLIDKPKPI
RADYVGLDVPNRYVFGYGMDAAGCWRNLGEIYALGGK
>NMB0930 xanthine/uracil permease family protein
MSGQLGKGADAPDLVYGLEDRPPFGNALLSAVTHLLAIFVPMITPALIVG
GALELPVEMTAYLVSMAMVASGVGTYLQVNRFGPVGSGMLSIQSVNFSFV
TVMIALGAGMKEGGLTKDAMISTLLGVSFVGAFLVCFSAWLLPYLKKVIT
PTVSGVVVMLIGLSLVHVGITDFGGGFGAKADGTFGSMENLGLASLVLLI
VLVFNCMKNPLLRMSGIAVGLIAGYIVALFLGKVDFSALQNLPLVTLPVP
FKYGFAFDWHAFIVAGAIFLLSVFEAVGDLTATAMVSDQPIEGEEYTKRL
RGGVLADGLVSVIATALGSLPLTTFAQNNGVIQMTGVASRHVGKYIAVIL
VLLGLFPVVGRAFTTIPSPVLGGAMVLMFGLIAIAGVRILVSHGIRRREA
VIAATSVGLGLGVAFEPEVFKNLPVLFQNSISAGGITAVLLNLVLPEDKT
EAAVKFDTDHLEH
>NMB0823 adk, adenylate kinase
MKALLLGAPGAGKGTQAQFITAAFGIPQISTGDMLRAAIKAGTPLGLEAK
KIIDEGGLVRDDIIIGMVKERIAQDDCKNGFLFDGFPRTLAQAEAMVEAG
VDLDAVVEIDVPDSVIVDRMSGRRVHLASGRTYHVTYNPPKVEGKDDVTG
EDLIQRDDDKEETVKKRLAVYHEQTEVLVDFYSKLEGEHAPKYIKVDGTQ
AVEAVKAEVLGALGK
>NMB1662 apt, adenine phosphoribosyltransferase
MLVHPEAMSVGALADKIRKIENWPQKGILFHDITPVLQSAEYFRLLVDLL
VYRYMDQKIDIVAGLDARGFIIGAALAYQLNVGFVPIRKKGKLPFETVSQ
SYALEYGEAAVEIHTDAVKLGSRVLLVDDLIATGGTMLAGLELIRKLGGE
IVEAAAILEFTDLQGGKNIRASGAPLFTLLQNEGCMKG
>NMB1849 carA, carbamoyl-phosphate synthase, small subunit
MSTPALLVLADGSVFHGTSIGYEGSTSGEVVFNTSMTGYQEILTDPSYCK
QIVTLTYPHIGNTGTNAEDEESRSVYAAGLIIRDLPLLHSNFRASESLHD
YLVRNKTVAIADIDTRRLTTLLREKGAQGGAILTGADATIEKAQELIAAF
GSMVGKDLAKEVSCTETYEWTEGEWALGKGFVTPDEQPYHVVAYDFGVKT
NILRMLASRGCRLTVVPAQTSAEDVLALNPDGVFLSNGPGDPEPCTYAIK
AVQKLIESGKPIFGICLGHQLISLAIGAKTLKMRFSHHGANHPVQDLDSG
KVVITSQNHGFAVDADTLPANARITHKSLFDNTLQGIELTDKPVFCFQGH
PEASPGPQDVGYLFDKFIGNMKAAKRA
>NMB1855 carB, carbamoyl-phosphate synthase, large subunit
MPKRTDLKSILIIGAGPIVIGQACEFDYSGAQACKALREEGYKVILVNSN
PATIMTDPEMADVTYIEPIMWQTVEKIIAKERPDAILPTMGGQTALNCAL
DLARNGVLAKYNVELIGATEDAIDKAEDRGRFKEAMEKIGLSCPKSFVCH
TMNEALAAQEQVGFPTLIRPSFTMGGSGGGIAYNKDEFLAICERGFDASP
THELLIEQSVLGWKEYEMEVVRDKNDNCIIICSIENFDPMGVHTGDSITV
APAQTLTDKEYQIMRNASLAVLREIGVDTGGSNVQFAVNPANGEMIVIEM
NPRVSRSSALASKATGFPIAKVAAKLAVGFTLDELRNDITGGKTPASFEP
SIDYVVTKIPRFAFEKFPAADDRLTTQMKSVGEVMAMGRTIQESFQKALR
GLETGLCGFNPRSEDKAEIRRELANPGPERMLFVADAFRAGFTLEEIHEI
CAIDPWFLAQIEDLMKEEKAVSDGILSDLDFAALRRLKRKGFSDKRLAQL
LNVSEKEVREHRYALKLHPVYKRVDTCAAEFATETAYLYSTYEEECESRP
SDRKKVMILGGGPNRIGQGIEFDYCCVHAALALRESGFETIMVNCNPETV
STDFDTSDRLYFEPLTLEDVLEIVRTENPWGVIVHYGGQTPLKLANALVE
NGVNIIGTSADSIDAAEDRERFQKVLNDLGLRQPPNRIAHNEEEALVKAE
EIGYPLVVRPSYVLGGRAMQVVHSAEELQKYMREAVQVSEDSPVLLDFFL
NNAIEVDVDCVSDGKDVVIGGIMQHVEQAGIHSGDSGCSLPPYSLSEEIQ
DEIRRQTKAMAYALGVVGLMNVQFAVQDGVVFVLEVNPRASRTVPFVSKA
TGVPLAKVGARCMAGISLKEQGVEKEVVPDFYAVKEAVFPFIKFPGVDTI
LGPEMRSTGEVMGVGASFGEAYYKAQLGAGERLNPTGKIFLSVREEDKER
VIKTAKNFQVLGYGICATRGTAQYLTEHGLIVQTINKVPEGRPHIGDALK
NGEIALVVNTVSSDPQSVSDSHIIRQSALQQRVPQYTTTAGGEAMSEGAK
SRDHLGVYSVQELHGRLKNRN
>NMB1300 cmk, cytidylate kinase
MNRQKVIAIDGPGASGKGTVAARVAAALGYDYLDTGALYRLTALYAQKQG
VGWHDEENVSELAKKLPAVFSGSRILLGGEDVSDGIRTEAIGMGASAVAQ
LPKVRAALLQRQRDFLTEKGLVADGRDTGSVVFPQAELKIFLTAESKIRA
ERRAKQIGIPCEGLAFERILSDIEARDEADRNRKVAPLKQQPDALLLDTS
RLTIEETVKKVLDWYREV
>NMB2067 cytX, probable hydroxymethylpyrimidine transporter CytX
MSGNASSPSSSSAIGLIWFGAAVSIAEISTGTLLAPLGWQRGLAALLLGH
AVGGALFFAAAYIGALTGRSSMESVRLSFGKRGSVLFSVANMLQLAGWTA
VMIYAGATVSSALGKVLWDGESFVWWALANGALIVLWLVFGARKTGGLKT
VSMLLMLLAVLWLSAEVFSTAGSTAAQVSDGMSFGTAVELSAVMPLSWLP
LAADYTRHARRPFAATLTATLAYTLTGCWMYALGLAAALFTGETDVAKIL
LGAGLGAAGILAVVLSTVTTTFLDAYSAGASANNISARFAETPVAVGVTL
IGTVLAVMLPVTEYENFLLLIGSVFAPMAAVLIADFFVLKRREEIEGFDF
AGLVLWLAGFILYRFLLSSGWESSIGLTAPVMSAVAIATVSVRLFFKKTQ
SLQRNPS
>NMB0893 dut, deoxyuridine 5`-triphosphate nucleotidohydrolase
MNIEVEMKVLDERMADVVPVYATEGSAGLDLRACLDEEVVLQPGETFLVP
TGLAIYLANPAYAAVLLPRSGLGHKHGIVLGNLVGLIDSDYQGELKVSLW
NRSSEPFTVKPFERIAQMVVVPIVQAGFKRVEEFVGSSRGEGGFGSTGSH
>NMB1839 fhs, formate--tetrahydrofolate ligase
MSFKTDAEIAQSSTMRPIGEIAAKLGLNADNIEPYGHYKAKINPAEAFKL
PQKQGRLILVTAINPTPAGEGKTTVTIGLADALRHIGKDAVIALREPSLG
PVFGVKGGAAGGGYAQVLPMEDINLHFTGDFHAIGAANNLLAAMLDNHIY
QGNELNIDPKRVLWRRVVDMNDRQLRNIIDGMGKPVDGVMRPDGFDITVA
SEVMAVFCLAKDISDLKERLGNILVAYAKDGSPVYAKDLKANGAMAALLK
DAIKPNLVQTIEGTPAFVHGGPFANIAHGCNSVTATRLAKHLADYAVTEA
GFGADLGAEKFCDIKCRLAGLKPDAAVVVATVRALKYNGGVERANLGEEN
LDALEKGLPNLLKHISNLKNVFGLPVVVALNRFVSDADAELAMIEKACAE
HGVEVSLTEVWGKGGAGGADLARKVVNAIESQTNNFGFAYDVELGIKDKI
RAIAQKVYGAEDVDFSAEASAEIASLEKLGLDKMPICMAKTQYSLSDNAK
LLGCPEDFRIAVRGITVSAGAGFIVALCGNMMKMPGLPKVPAAEKIDVDA
EGVIHGLF
>NMB1661 gmk, guanylate kinase
MSAYRKGNIFIISAASGTGKTTLVSRLLANHNGLRVSVSHTTRPPREGEA
NGVHYHFVSKEEFESLIAQEAFLEYADVFGNYYGTGAEGVNALAAAGYDV
ILEIDVQGAAQVRDALPEAVGIFILPPSFDVLAARLNGRGTDSREVIQRR
LSKARHEIEQSVLFDFVVVNDDLARAEEDLRHIVNACRLKRSRQLGFIAD
LLENS
>NMB1920 guaA, GMP synthase
MTQDKILILDFGSQVTQLIARRVREAHVYCELHSFDMPLDEIKAFNPKGI
ILSGGPNSVYESDYQADTGIFDLGIPVLGICYGMQFMAHHLGGEVQPGNQ
REFGYAQVKTIDSELTRGIQDGEPNTLDVWMSHGDKVSKLPDGFAVIGNT
PSCPIAMMENAEKQFYGIQFHPEVTHTKQGRALLNRFVLDICGAQPGWTM
PNYIEEAVAKIREQVGSDEVILGLSGGVDSSVAAALIHRAIGDQLTCVFV
DHGLLRLNESKMVMDMFARNLGVKVIHVDAEGQFMAKLAGVTDPEKKRKI
IGAEFIEVFDAEEKKLTNAKWLAQGTIYPDVIESAGAKTKKAHAIKSHHN
VGGLPENMKLKLLEPLRDLFKDEVRELGVALGLPREMVYRHPFPGPGLGV
RILGEVKKEYADLLRQADDIFIQELRNTTDENGTSWYDLTSQAFAVFLPV
KSVGVMGDGRTYDYVIALRAVITSDFMTAHWAELPYSLLGKVSNRIINEV
KGINRVVYDVSGKPPATIEWE
>NMB0602 hitA, hitA protein
MDNCIFCKIAAKDIPAQTVYEDGEMVCFKDINPAAPVHLLLIPKVHFDSL
AHAAPEHQMLLGKMMLKVPEIAKAAGLADGFKTLINTGKGGGQEVFHLHI
HIMGTPV
>NMB1307 ndk, nucleoside diphosphate kinase
MAIERTISIIKPDAVGKNVIGKIYSRFEENGLKIVAAKMKQLTLKEAQEF
YAVHKDRPFYAGLVEFMTGGPVMIQVLEGENAVLKNRELMGATNPSEAAE
GTIRADFATSVSINAVHGSDSVENAALEIAYFFSQTEICPR
>NMB1291 nrdA, ribonucleoside-diphosphate reductase, alpha subunit
MNTPTDLKVTKRDGRLEAIDLDKIHRVVTWAADGLENVSVSQVELKSHIQ
FYNGIRTDDIHETIIKAAADLISEDTPDYQYLAARLAIFHLRKIAYGEYE
PPHLYDHVKKLTDAGKYDRHILEDYSREEFDELNAYIDHERDMSFSYAAV
KQLEGKYLVQNRVTRQIYETPQFLYVLVAMCLFSKYPKEARLGYVKRFYD
AVSTFKVSLPTPIMSGVRTPTRQFSSCVLIECDDSLDSINATTSAIVKYV
SQRAGIGINAGRIRGLDSEIRGGEARHTGCIPFFKMFQAAVKSCSQGGVR
GGAATLFYPLWHIEAESLLVLKNNRGVEDNRIRQLDYGVQINRLLYTRLI
KGGNITLFSPNEVPGLYEAFFADQDEFERLYTKYEQDPDIRKRIIPAADL
FSTLMQERAGTGRIYIQNVDHCNTHSPFDPRVAPVHQSNLCMEIALPTKP
LDNINDPNGEIALCTLSAFNLGALNSLDELEGLADLTVRALDALLDYQGY
PVEAARTSTMGRRSLGIGVINYAYYLAKNGVRYSDGSALGLTHRTFEAIQ
YYLLKASANLAKEYGACTLFNQTVYSQGKLPIDTYKKDLDAVCGEPLHYD
WESLRAEIVKYGLRNSTLTALMPSETSSQIANATNGIEPPRGLVTVKASK
DGILKQVVPEFETLKNAYETLWQLPGNEGYLKLVGVMQKFVDQSISANTA
YDPGKFEGGKVSMKQMLKDLLTAYKYGVKTLYYHNTRDGADDTQTDIQDD
GCAGGACKI
>NMB1288 nrdB, ribonucleoside-diphosphate reductase, beta subunit
MSCEHLTMSYSTFPKTKNDALNEPMFFGQPVNVARYDQQKYEVFEKLIEK
QLSFFWRPEEIDVSRDRIDYANLPEHEKHIFISNLKYQTLLDSIQGRSPN
VALLPLVSIPELETWIETWSFSETIHSRSYTHIIRNIVNDPSVVFDDIVE
NEYITARAEDIACYYDDLIEYTQYYNLLGEGVHNVGGKPVTVSLRGLKKK
LYLCLMCVNVLEAIRFYVSFACSFAFAERELMEGNAKIIKLIARDEALHL
TGTQHMLNLMRSGVDDSEMAEIAAELQDECFQLFKKAAEQEKEWAAYLFK
DGSMIGLNKEILSQYVEYITNLRMQAVGLPAGFEGANQNPIPWINAWLSS
DNVQVAPQEVEISSYLIGQIDSEVNTDDLGDFEL
>NMB0767 pfs, 5-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase
MSLKTVAVIGAMEQEIELLREMMENVKAVSFGRFSAYEGELAGKRMVLAL
SGIGKVNAAVATAWIIREFAADCVINTGSAGGLGKGLKVGDVVIGTETAH
HDVDVTAFGYAWGQVPQLPARFASDGILIEAAKRAARTFEGAAVEQGLIV
SGDRFVHSSEGVAEIRKHFPEVKAVEMEAAAIAQTCHQLETPFVIIRAVS
DSADEKADISFDEFLKTAAANSAKMVAEIVKSL
>NMB1467 ppx, exopolyphosphatase
MTTTPANVLASVDLGSNSFRLQICENNNGQLKVIDSFKQMVRFAAGLDEQ
KNLSAASQEQALDCLAKFGERLRGFRPEQVRAVATNTFRVAKNIADFLPK
AEAALGFPIEIIAGREEARLIYTGVIHTLPPGGGKMLVIDIGGGSTEFVI
GSTLNPDITESLPLGCVTYSLRFFQNKITAKDFQSAISAARNEIQRISKN
MRREGWDFAVGTSGSAKSIRDVLAAEMPQEADITYKGMRALAERIIEAGS
VKKAKFENLKPERIEVFAGGLAVMMAAFEEMKLDRMTVTEAALRDGVFYD
LIGRGLNEDMRGQTVAEFQHRYHVSLNQAKRTAETAQTFMDSLCHAKNVT
VQELALWQQYLGRAAALHEIGLDIAHTGYHKHSAYILENADMPGFSRKEQ
TILAQLVIGHRGDMKKMSGIIGTNEMLWYAVLSLRLAALFCRSRQDLSFP
KNMQLRTDTESCGFILRIDREWLERHPLIADALEYESVQWQKINMPFKVE
AV
>NMB0875 prsA, ribose-phosphate pyrophosphokinase
MAAYDSLMVFTGNANPELAQRVVRHLDISLGNASVSKFSDGEVAVELLEN
VRGRDVFILQPTCAPTNDNLMEILTMADALKRASAGRITTAIPYFGYARQ
DRRPRSVRVPISAKLVANMLYSAGIDRVLTVDLHADQIQGFFDIPVDNIY
ATPILLNDIKQQRIENLTVVSPDIGGVVRARAVAKSLNADLAIIDKRRPK
ANVAEVMNIIGDIQGRTCLIVDDMIDTANTLCKAAVALKERGAERVLAYA
SHAVFSGEAVSRIASSEIDQVVVTDTIPLSEAAKNCDRIRQVTIAGLLAE
TVRRISNEESVSYLFNEEVMTGSMLLP
>NMB0815 purA, adenylosuccinate synthetase
MAMAKNVVVIGAQWGDEGKGKIVDWLAEEAGGVVRFQGGHNAGHTLVVGG
KKTILRLIPSGILHESLDCFIGSGVVVSPEALLGEIDELNAAGVKNVEGR
LKIAPTCPLILPYHIALDQAREASRGKGKIGTTGRGIGPAYEDKVARRAI
RAADLLHPEKLREKLDAVLAYYNVQLQHLHNAEPVKAEDVMAVIEKVAPR
IAPMITDVSRVLNEKNKNGEKLLFEGAQGALLDIDYGTYPFVTSSNCLAG
AASAGAGVGPQMLDYVLGIVKAYTTRVGSGPFPTELFDEVGVGLAERGHE
FGSVTGRARRCGWFDAAALKRSIQINGISGMCITKLDVMDGVETINICVG
YELPDGGKTDILPCGSDAVETCKPIYETMPGWRESTFGVKDYGALPENAK
AYLKRIEEVCGAPVAIVSTGPDREETIVLHHPFA
>NMB0284 purB, adenylosuccinate lyase
MINPIASLSPLDGRYAQSVEALRPIFSEYGLMKARVKVELNWLKALAAEP
KIAEVPPFSAETLAEIDTVIENFSLEDAAAVKAIEATTNHDVKAIEYWLK
KRFAEVPEVAAVSEFIHFACTSEDINNLSHALMLQEAREAVLLPKLAEII
EKLTAMAHDLAAVPMMSRTHGQPATPTTLGKETANVVYRLQRQFKNLQAQ
EFLGKINGAVGNYNAHMVAYPDVDWETHCRNFVEISLGLTFNPYTIQIEP
HDYMAEFFQTLSRINTILIDFNRDVWGYISLGYFKQKVKAGEVGSSTMPH
KVNPIDFENSEGNLGMANAVLGFLSEKLPISRWQRDLTDSTVLRNMGVGV
GYAVLGFAAHLRGLNKLEPNPAALAADLDATWELLAEPIQTVMRRYGVAN
PYEKLKDLTRGKGGITPEVLKGFIGLLEIPAEAKAKLLELTPALYVGKAE
ALAKRI
>NMB0757 purC, phosphoribosylaminoimidazole-succinocarboxamidesynthase
MSEIGLVKIYFGKVRDLYEIDDKRMLMVASDRLSAFDVILDDPIPSKGEI
LTQISNFWFKKLAHIMPNHFTGQTVYDVLPENEAKALEKRAVVAKKLTPV
KVEAIVRGYLAGSGWKDYQKTGSVCGIQLPEGMQEAQQLPEVIFTPSTKA
AVGDHDENISFEECGRIIGKELAEEVRAKAVRLYTEAAEYAKSRGIIICD
TKFEFGLDENGTLTLMDEVLTPDSSRFWPADQYKVGTNPPSFDKQFVRDW
LEQSGWNKKAPAPKVPADVIQKTVEKYREALTLLTQD
>NMB2151 purD, phosphoribosylamine--glycine ligase
MKLLVIGNGGREHALAWKLAQSPKVETVFVAPGNAGTAIEPKLQNIDLTA
HQDLIEFCRKENIVFTVVGPEAPLAAGIVDDFRAAGLKIFGPTQYAAQLE
SSKDFAKAFMAKYNIPTAQYQTFENADAAHDYVNQKGAPIVIKADGLAAG
KGVIVAMTLDEAHAAIDDMLLDNKMGNAGARVVIEDFLQGEEASFIVMVD
GNNVLPMATSQDHKRLLDGDKGLNTGGMGAYSPAPVVTPVVYERAMNEII
LPTVAGMKAEGHEFTGFLYAGLMIDQSGAPYTIEFNCRFGDPETQPIMSR
LNSDLSDLVEAAIDGKLDSVTAEWSPQTAVGVVLAAQNYPETPKKGDIIS
GLDAANQIGKVFHAGTTANEKGDVLTNGGRVLCVVGLGDNVAQAKAKAYG
ALEKISFDGMQYRKDIADKAINR
>NMB1439 purE, phosphoribosylaminoimidazole carboxylase, catalytic subunit
MIQIGIIMGSNSDWPVMRQAAQFLEEFGVEYEARVVSAHRTPDLMFQYAE
TARARGIKAIIAGAGGAAHLPGMVAAKTTVPVLGVPVPSKYLRGEDSLLS
IVQMPKGVPVATFAIGEAGAANAALFAVSMLANETPELAQKLADFRAKQE
QAVLNMELEQI
>NMB0690 purF, amidophosphoribosyltransferase
MCGVLGLVSHEPVNQLLYDGLQMLQHRGQDAAGIATAEGGTFHMHKGKGM
VREVFRTRNMRDLTGNAGIAHVRYPTAGNAGSSAEAQPFYVSSPFGIVLA
HNGNLTNTAELYENVCNKHLRHVNTSSDSEVLLNVFAHELRREVSKNADP
HRLNADNIFNAVAQVHRLVRGAYGVIAMIAGYGMLAFRDPYGIRPLVLGS
QTDSEGRKSYAVASESVAFNALTYDLERDIRPGEAVFVGFDGTMIARQCS
DRAKLSPCLFEYVYFARPDSVIDGVSVYQSRLDMGVSLAEKIKRELPVDG
IDVVMPIPDTSRPSAMELAVHLDKPYREGLIKNRYIGRTFIMPGQATRKK
SVRQKLSPMETEFAGKSVLLVDDSIVRGTTSREIVEMVRAAGARKVYIAS
AAPEVRYPNVYGIDMPTREELIANGRSAAEIAAEIGADGIVFQDLGDLEA
VVKALNPKIESFDSSCFNGIYQTGDIDDAYLDRLSAEKSGCGGLKIHPSR
MEHSISISDAGDEE
>NMB0983 purH, phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
MSSIKRALISLSDKTGAVEFAQTLHKLGVEILSTGGTAKLLADAGVPVIE
VADYTGFPEMLDGRVKTLHPKIHGGILGRRDLDEHVAKMEEHGIGNIDLV
CVNLYLFAATIAKPNCTLEDAIENIDIGGPTMVRSAAKNWKHVAIVTDTA
DFPAIAAELEANNGALSDKTRFNLSRKAFSHTAQYDGMISNYLTSLSDDV
LSGTPEIAGFPGRFNQSWIKVQDMRYGENPHQRAAFYRDIDPAAGSLAAY
KQLQGKELSYNNIADADAAWEAVKSFDVPACVIVKHANPCGVAIASNTLD
AYKLAYATDTTSAFGGIIAFNREVDGATVKQITDNQFMEVLMAPKFTAEA
LEIAAAKKNVRVLEVPLEAGANRFELKRVGGGLLVQTPDIHRISRADLKV
VSKRQPTEQEWNDLLFVWNVAKYVKSNAIVFGKGGQTYGIGAGQMSRVDS
TRIAARKAQDAGLDLNGACAASDAFFPFRDGVDVIAEQGIKAIIHPAGSM
RDQEVFDAADEHGIAMVVTGIRHFRH
>NMB1019 purK, phosphoribosylaminoimidazole carboxylase, ATPase subunit
MKNISLSPPAMLGILGGGQLGRMFTVAAKTMGYKVTVLDPDPDAPAAEFA
DRHLCAPFNDQAALDELAKCAAVTTEFENVNADAMRFLAKHTNVSPSGDC
VAIAQNRIQEKAWIRKAGLQTAPYQVVCKAEDITEASAQFLPGILKTATL
GYDGKGQIRVKTLDELKAAFAEHGGVDCVLEKMVDLRSEISVIVCRLNND
NVQTFDPAENIHENGILAYSIVPARLSADVQQQARQMAQRLADELDYVGV
LAVEMFVVGDTHELVVNEIAPRPHNSGHHTIDACAADQFQQQVRIMCNLP
PADTKLLSSCCMANILGDVWQEDGGEPDWLPLQSHPNAHLHLYGKKTAHK
GRKMGHFTVLTTDSDTAFQEAKKLHQSL
>NMB1996 purL, phosphoribosylformylglycinamidine synthase
MSVVLPLRGVTALSDFRVEKLLQKAAALGLPEVKLSSEFWYFVGSEKALD
AATVEKLQALLAAQSVEQTPKAREGLHLFLVTPRLGTISPWASKATNIAE
NCGLAGIERIERGMAVWLEGRLNDEQKQQWAALLHDRMTESVLPDFQTAS
KLFHHLESETFSGVDVLGGGKEALVKANTEMGLALSADEIDYLVENYQAL
QRNPSDVELMMFAQANSEHCRHKIFNADFILNGEKQPKSLFGMIRDTHNA
HPEGTVVAYKDNSSVIEGAKIERFYPNAAENQGYRFHEEDTHIIMKVETH
NHPTAIAPFAGAATGAGGEIRDEGATGKGSRPKAGLTGFTVSNLNIPDLK
QPWEQDYGKPEHISSPLDIMIEGPIGGAAFNNEFGRPNLLGYFRTFEEKF
DGQVRGYHKPIMIAGGLGSIQAQQTHKDEIPEGALLIQLGGPGMLIGLGG
GAASSMDTGTNDASLDFNSVQRGNPEIERRAQEVIDRCWQLGGKNPIISI
HDVGAGGLSNAFPELVNDARRGAVFKLREVPLEEHGLNPLQIWCNESQER
YVLSILEKDLDAFRAICERERCPFAVVGTATDDGHLKVRDDLFANNPVDL
PLNVLLGKLPKTTRTDKTVAPSKKPFHAGDIDITEAAYRVLRLPAVAAKN
FLITIGDRSVGGLTHRDQMVGKYQTPVADCAVTMMGFNTYRGEAMSMGEK
PTVALFDAPASGRMCVGEAITNIAAVNIGDIGNIKLSANWMAACGNEGED
EKLYRTVEAVSKACQALDLSIPVGKDSLSMKTVWQDGEEKKSVVSPLSLI
ISAFAPVKDVRKTVTPELKNVEDSVLLFVDLGFGKARMGGSAFGQVYNNM
SGDAPDLDDTGRLKAFYSVIQQLVAENKLLAYHDRSDGGLFAVLVEMAFA
GRCGLDIDLNLLLAQTFITNHTALSQSLRTEEVKALAEWQETIARTLFNE
ELGAVIQVRKQDVADIINLFYQQQLHHNVFEIGTLTDENTLIIRDGQTHL
ISDNLIKLQQTWQETSHQIQRLRDNPACADSEFALIGDNERSALFADVKF
DVNEDIAAPFINSGAKPKIAILREQGVNGQIEMAAAFTRAGFDAYDVHMS
DLMAGRIHLADFKMLAACGGFSYGDVLGAGEGWAKSILFHPALRDQFAAF
FADPDTLTLGVCNGCQMVSNLAEIIPGTAGWPKFKRNLSEQFEARLSMVH
VPKSASLILNEMQGSSLPVVVSHGEGRADFALHGGNISADLGIALQYIDG
QNQVTQTYPLNPNGSPQGIAGVTNADGRITIMMPHPERVYRAAQMSWKPE
GWTELSGWYRLFAGARKALG
>NMB1252 purM, phosphoribosylformylglycinamidine cyclo-ligase
MSTSLSYRDAGVDIDAGDQLVENIKPFAKRTMRPEVLGDLGGFGALVEIG
KKYQNPVLVSGTDGVGTKLKLAFDWDKHDTVGIDLVAMSVNDILVQGAEP
LFFLDYFACGKLDVPRATDVIKGIAQGCEESGCALIGGETAEMPGMYPVG
EYDLAGFAVGVVEKENVITGRSIGVGDVVLGLASNGAHSNGYSLIRKIIE
RDNPDLDAEFDNGKTLREAVIAPTRLYVKPILAALEKFTIKGMAHITGGG
ITENVPRVLPENTVAQIDAKSWELPKLFQWLQKAGNVETQEMYRTFNCGI
GMVVIVAAEDADAVQGLLGEQGETVYRLGLIRERQGDEHQTQVA
>NMB1566 purN, phosphoribosylglycinamide formyltransferase
MKNIVILISGRGSNMQAIVNAAIHNVRIAAVLSNSETAAGLQWAAERGIP
TDSLNHKNFTSRLAFDTAMMEKIDAYQPDLVVLAGFMRILTPEFCARYEG
RLMNIHPSILPSFTGLHTHERALEAGCRVAGCTIHFVTAELDCGPIVSQG
VVPILDGDTADDIAARVLAVEHKLYPKAVADFAAGRLIIEGNRVRNSENA
DAARFLTA
>NMB0106 pyrB, aspartate carbamoyltransferase, catalytic subunit
MPNPLYRQHIISISDLSREQLECLLQTALKLKAHPRGDLLEGKLIGSCFF
EPSTRTRLSFETAVQRLGGKVIGFSDGANTSAKKGETLADTARIISGYTD
AIIQRHPKDGAARVAAEFSRVPVINAGDGTNQHPSQTLLDLVTIYETQGR
LDKLKIAMAGDLKYGRTVHSLCQALKRWNCEFAFVSPPSLAMPDYITEEL
DEAGCRYRILGSLEEAAEWADILYMTRVQRERFDEQEFAKIQGKFNLEAS
MLARAKPNLRVLHPLPRVDEIHPDVDATPHAYYFEQATNGVYARMAILSL
VLNEEV
>NMB0682 pyrC, dihydroorotase
MQTLTIIRPDDMHLHLRDGDALKAVAPYTARQMGRAVIMPNLKPPVVSVA
DALAYKARIMAALPEGSAFEPLMTLYLTDNATPELVREAKAAGIVAFKLY
PAGATTNSDSGVTDLFKLIPVLEEMAKQGILFLVHGEVTDPEIDIFDREA
AFIGRVMKPVLAQVPNLKVVFEHITTAEAARLVLEAGDNVAATVTPQHLL
LNRNDLLVGGVRPHHFCLPVLKRETHRQALVAAVTGEKAHKFFLGTDSAP
HAKSAKENACGCAGMFSAMTAIELYAEVFEKAGALDKLEAFASKNGARFY
GIPENTDTITLVKQSQTVPASVPYGDGELVPMRAGGEIGWTVQY
>NMB0221 pyrD, dihydroorotate dehydrogenase
MYPLARRILFALDAEKAHHFTLDALYTVYKLGLIPVTDNRTKPVKLMGMD
LPNPVGLAAGLDKNGEYIDALGALGFGFIEIGTVTPNPQPGNPQPRLFRV
PEHQGIINRMGFNNHGIDTMIRNIEKSKFSGVLGINIGKNAVTPIENAAD
DYLICLEKAYAHASYITVNISSPNTKNLRALQGGDELSALLEALKNKQAQ
LASVHGKYVPLAVKIAPDLDEAQIEDIAHVVKSVEMDGIIATNTTIDKSS
LGSHPLAGEQGGLSGLPVHEKSNRVLKLLADHIDGKLPIIGVGGIMEGED
SADKIRLGATAVQVYSGLIYKGPALVKECLKALAR
>NMB1874 pyrE, orotate phosphoribosyltransferase
MTDFRQDFLKFSLAQNVLKFGEFTTKAGRRSPYFFNAGLFNDGLSTLQLA
KFYAQSIIESGIRFDMLFGPAYKGIILAAATAMMLAEKGVNVPFAYNRKE
AKDHGEGGVLVGAPLKGRVLIIDDVISAGTSVRESIKLIEAEGATPAGVA
IALDRMEKGTGELSAVQEVEKQYGLPVAPIASLNDLFILLQNNPEFGQFL
EPVRAYRRQYGVE
>NMB0824 pyrF, orotidine 5`-phosphate decarboxylase
MNPLISDFQTPQQRTPVIVALDFSNEKDTLGFVRNLDPTLCQIKIGKELF
TATGRNLAESLINQGFKLFLDLKYHDIPHTVAQACKVAADMGVWMVDMHA
SGGRRMMEAAAEAVAGYGTKPLLIGVTVLTSMEQSDLAEIGLNTAPEEQV
IRLAKLAQSSGLDGVVCSAQEAAPLRRELGQDFVLVTPGIRLDVAGNNDD
QRRIMTPAEALAAGSTYLVMGRPVTQAADPVAVLREVNRVANLEAN
>NMB1554 pyrG, CTP synthase
MTKFIFVTGGVVSSLGKGIAAASIAAILESRGLNVTMLKLDPYINVDPGT
MSPFQHGEVFVTDDGAETDLDLGHYERFIDSTMTRRNSFSTGQVYENVIA
KERRGDYLGGTVQVIPHITDEIKRRIHEGAAGYDVAIVEIGGTVGDIESL
PFLEAIRQMRSQLGRNNTLFAHLSYVPYIAAAGEIKTKPTQHTVKEMLSI
GLQPDILICRMDRTMPADERRKIALFCNVEERAIVGSYDVDSIYECPEML
HDQGIDNIITEQLQLNVQQADLTAWKKIVHAIQNPKHTVKIAMVGKYVDL
TESYKSLIEALKHAGIHTETDVQITFVDSENIEKNKGDVSMLKDMDAILV
PGGFGSRGVEGKIAAVRYARENNVPYLGICLGMQIALIEYARDVAGLKGA
NSTEFDLKCAAPVVALIDEWQTADGSVETRDESTDLGGTMRLGAQEVELK
AGSLAAKIYGSGHIRERHRHRYEVNNNYVPTLEQAGLVIGGVSAGRERLV
ETIELPNHPWFFACQFHPEFTSNPRKGHPLFTAFVKAALNNKKA
>NMB2103 pyrH, uridylate kinase
MTQQIKYKRVLLKLSGESLMGSDPFGINHDTIVQTVGEIAEVVKMGVQVG
IVVGGGNIFRGVSAQAGSMDRATADYMGMMATVMNALALKDAFETLGIKA
RVQSALSMQQIAETYARPKAIQYLEEGKVVIFAAGTGNPFFTTDTAAALR
GAEMNCDVMLKATNVDGVYTADPKKDPSATRYETITFDEALLKNLKVMDA
TAFALCRERKLNIVVFGIAKEGSLKRVITGEDEGTLVHC
>NMB0107 pyrI, aspartate carbamoyltransferase, regulatory subunit
METPKLSVEAIEKGTVIDHIPAGRGLTILRQFKLLHYGNAVTVGFNLPSK
TQGSKDIIKIKGVCLDDKAADRLALFAPEAVVNTIDNFKVVQKRHLNLPD
EIAEVFRCPNTNCAGHGEPVKSRFYVKKHNGQTRLKCHYCEKTYSRDSVA
EA
>NMB1709 thyA, thymidylate synthase
MKAYLDLMRHVLDNGTDKSDRTGTGTRSVFGYQMRFDLGKGFPLLTTKKL
HLRSIIHELLWFLKGDTNIKYLKDNNVSIWDEWADENGDLGPVYGYQWRN
WPAPDGRHIDQIANVLEQIKKNPDSRRLIVSAWNPALVDEMALPPCHALF
QFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFV
HTFGDAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLFSFKFEDFELE
GYDPHPHIKAAVSV
>NMB0670 tmk, thymidylate kinase
MKPQFITLDGIDGAGKSTNLAVIKAWFERRGLPVLFTREPGGTPVGEALR
EILLNPETKAGLRAETLMMFAARMQHIEEVILPALSDGIHVVSDRFTDAT
FAYQGGGRGMPSEDIEILEHWVQGGLKPDLTLLLDVPLEVSMARIGQTRE
KDRFEQEQADFFMRVRGVYLDRAAACPERYAVIDSNRNLDEVRNSIEKVL
DGHFGC
>NMB0774 upp, uracil phosphoribosyltransferase
MNVNVINHPLVRHKLTLMREADCSTYKFRTLATELARLMAYEASRDFEIE
KYLIDGWCGQIEGDRIKGKTLTVVPILRAGLGMLDGVLDLIPTAKISVVG
LQRDEETLKPISYFEKFVDSMDERPALIIDPMLATGGSMVATIDLLKAKG
CKNIKALVLVAAPEGVKAVNDAHPDVTIYTAALDSHLNENGYIIPGLGDA
GDKIFGTR
>NMB1315 uraA, uracil permease
MNQLKLAVSGAQILFVAFGAMVLVPLLTGLNPALALLGAGLGTLLFQITT
KRKVPIFLGSSFAFIAPIIYSVGEWGLPSTMFGLFAAGFMYFVFAALIRW
RGLAAVHKLLPPVVIGPVIMVIGLSVAVAASSMAMGQADGKQVIDYTDSL
ILSGFTFAVTAIVSVFGSRMMKLIPILIGVASGYVLALLMGLVDTASIAH
APWFAVPHFETPQINWQAALFMLPVAVAPAIEHIGGIMAIGNVTGKDYTK
DPGLDKTLAGDGLGVCVAGLIGGPPVTTYGEVTGAVMITKNSNPVIMTWA
AVFAVCMAFFGKFNAFLASIPMPVMGGIMLLLFGTIASLGVKTLIDAKVD
LMLPKNLVIVSSVLTTGIGGMTLKLGSFSFAGVGLCAVLAIMLNSLLPDP
KES