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# Streptococcus pyogenes M1 GAS, SF370

>SPy0351 hypothetical protein
MKLTLNRILFSGLALSILLTLTGCVGRDAHGNPKGMIWEFLGKPMSYFID
YFANNAGLGYGLAIIIVTIIVRTLILPLGLYQSWKASYQSEKMAFLKPVF
EPINKRIKQANSQEEKMAAQTELMAAQRAHGINPLGGIGCLPLLIQMPFF
SAMYFAAQYTKGVSTSTFMGIDLGSRSLVLTAIIAALYFFQSWLSMMAVS
EEQREQMKTMMYTMPIMMIFMSFSLPAGVGLYWLVGGFFSIIQQLITTYL
LKPRLHKQIKEEYAKNPPKAYQSTSSRKDVTPSQNMEQANLPKKIKSNRN
AGKQRKR
>SPy1438 hypothetical protein-phage associated
MTFLDKIKQGCLDGWTTYKILPSLTAAQTILESGWGKHAPHNALFGIKAD
SSWTGKSFDTKTQEEYQAGVVTDIVDRFRAYDSWTDSIIDHGKFLNDNPR
YQAVIGETDYKKACHAIKDAGYATASGYAELLIQLIEENDLQEWDEEAIV
RKEKQMISSQCREVIEFFINLVNAGVGVDKDGFAGWQCTDVPCYAAKHWF
GVDLWGNAIDLLDSAAAVGWEVHRMPTDANPQTGAFFVQSVPYHQFGHTG
VVIEDSDGYTMRTIEQNIDGNPDALYVGAPARFNTRDFTGVTGWFYPPYQ
GDIVTQPVSTEPQTSDTIVETAKTGTFTLDVAEINIRRWPSLTSEVVGSY
KQGDTISFDSEGYANGYYWISYVGGSGMRNYTAIGITDKDGNIISLWGKL
N
>SPy0127 putative signal peptidase I
MIIKRNDMAPSVKAGDAILFYRLSQTYKVEEAVVYEDSKTSITKVGRIIA
QAGDEVDLTEQGELKINGHIQNEGLTFIKSREANYPYRIADNSYLILNDY
YSQESENYLQDAIAKDAIKGTINTLIRLRNH
>SPy0105 hypothetical protein
MIATGILFSIVILVLSSLQQSQAALTYYRKQQEKLNLALMAVQTRTKEMT
LNGCHITILRTDRYISIHDDEGEVMKIE
>SPy1968 hypothetical protein
MGFPPILMFVVMLGLIWFMQRQQKKQAQERQNQLNAIEKGDEVVTIGGMF
AIVDEVDTTAKKIVLDVDGVFLTFELLAIKRIVTKATTETTLVETEETSV
VNEPAVETVDSTDTDSAIESH
>SPy0128 hypothetical protein
MKLRHLLLTGAALTSFAATTVHGETVVNGAKLTVTKNLDLVNSNALIPNT
DFTFKIEPDTTVNEDGNKFKGVALNTPMTKVTYTNSDKGGSNTKTAEFDF
SEVTFEKPGVYYYKVTEEKIDKVPGVSYDTTSYTVQVHVLWNEEQQKPVA
TYIVGYKEGSKVPIQFKNSLDSTTLTVKKKVSGTGGDRSKDFNFGLTLKA
NQYYKASEKVMIEKTTKGGQAPVQTEASIDQLYHFTLKDGESIKVTNLPV
GVDYVVTEDDYKSEKYTTNVEVSPQDGAVKNIAGNSTEQETSTDKDMTIT
FTNKKDFEVPTGVAMTVAPYIALGIVAVGGALYFVKKKNA
>SPy0104 putative competence protein
MKKPVLAIKAFTLLETLLSLSVMSFIILGLSVPVTKSYQKVEEHLFFSHF
EHLYRHQQKLAILQQKQRVLDISSTKIVTEGNSLTVPKSITVNHPYRLVI
DQMGGNHSLAKIIFDMTDRRFKYQFYLGSGNYQKTSQSLHSP
>SPy0998 conserved hypothetical protein-phage associated
MSRDPTLTLDESNLVIGKDGRVHYTFTASQDNQTVRLASNCLGTAHFNQL
MIERGDKATGYVAPVVVEGSGELTGVFKSLEEMLSSLRSINLELTDTKDS
KLWSKIKLTNRGMLQEYYDGKIKTEIVNSAQGVATRITEETGKKLALINE
SINGIRREYQNADKKLSASYQLGIDGLKATMRSDKIGLQAEIQTTAQGLY
QRYDNEIRKLSAKITTTSSGTTEAYESKLDGLRAEFTHSNQGMRVELESK
ISGLQSTQQATARQISQEISNREGAVSRVQQGLDSYQRRLQSAEGNYNSL
RETVAGYERRISNQDNTISSNFTQLKSLINQSVTLGKIQSLLRQSGDSIM
LAIKDKIPQSKMSGSDIISAINLNSRGVQIAGKNIALDGNTTVNGAFGAK
LGEFIKLRADQIIGGTIDANKINVINLKASSIVGLDANFIKARISYAITD
LLEGKVIKARNGAMTIDLQSGQINHYTNESAMRRIDSSTASQFIKMTKSG
FISEIGNMQAAMTVIGSNSDGSENHENKTFGGIRIWNGKSSYQSTSFVEL
VGNRVAIYGNKNRSPWLFDSTTSGYAYLIPQNDRGIKHVIGRADRKIDQI
HVGDIYVQGERVAMMLKDLALKIGYIGTGGWANRIG
>SPy1728 putative ABC transporter (permease)
MKALFLKRRQDFQKQQNKYLRYVLNDHFVLVLMFLLGFAMVQYGQLLNHF
PTNHLPIQVCLGILIPLLLSMGSIATYLEEADQHFLLPKEEEVISYIKQA
ERLSFLLWGTLQTAVLLFLYPIFRRLGLSLFIFIILVLILLALKRVVLSR
KTRYFLRGNRLDWAKAVAFESNRKQSILKFYSLFTTVKGISTKVKERTYL
NPLLKLVKQTPSNLWLSLYARAFLRSSDYLGLFLRLMLLSSLSVFFIHNL
YLSVSLALIFNYLVVFQLLSLYYHYDYHYMTSLYPENSRSKKKNMLSFLR
GLSFLMLIVNMLCCSSAPKALILIVGMVFIACIYLPYKLKKIID
>SPy0710 conserved hypothetical protein, phage associated
MTFLDKIKQGCLDGWAKYKILPSLTAAQAILESGWGKHAPHNALFGIKAD
SSWTGKSFDTKTQEEYQAGVVTDIVDRFRAYDSWDESIADHGQFLVDNPR
YEAVIGETDYKKACYAIKAAGYATASSYVELLIQLIEENDLQSWDREALK
NNKEETMTTANEIVQYCVNLANSGMGVDKDGAHGTQCCDLPCFVAKNWFG
VDLWGNAIDLLDSASAQGWEVHRMPTEANPKAGATFVQSVPYHQFGHTGI
VIEDSDGYTMRTVEQNIDGNPDALYVGAPARFNTRDFTGVIGWFYPPYQG
DTVTQPVSTEPQTSDTIVETAKTGTFTLDVAEINIRRWPSLASEVVGIYK
QGDTVSFDSEGYANGYYWISYVGGSGMRNYLGIGQTDKDGNRISLWGKLN
>SPy1532 hypothetical protein
MIAFFSICSGILLTHLFYCLLLYFPDNGQEQLSKQTVIVCDQLTFAKRVF
RQFQNHFITSQKIFFSLEIGLIIILWASMVHWVSASYCYLLLFSLLFSLF
DWRSQEYPFILWLFSFVSLLLFYSINYLSLILLLLGLLAHLRPFSIGAGD
FFYLASLALVLDLTSLIWLIQLASLAGITACLLLGIKRIPFIPYLSFGLF
WIVLLEHF
>SPy1764 putative N-acetyl-muramidase
MRKRLKFPYFLTLLACFLLLIVCPLLSSQRIASADKEVRVNYSQKQFITK
MGKEVKPLAKYYGIRPSILIAQILLETHDGKTLLASKYHNLFSKKATPGQ
VAITLKSPKQTNQNVRYAIYKDDASAIRDYLRMLRQGKEVDKRLYRNLAT
EKGYKAPAKSLQKYLHYTDKTYARRLIQVIESNDLTNYD
>SPy0502 hypothetical protein
MYNLLLTILLVLSGLLEIAIFMQPQKNPSSNVFDSSGSEALFERTKARGF
EAFMQRFTAVLVFFWLAIALVLAILSSK
>SPy0247 conserved hypothetical protein
MRKVLRVKKNIKIARIVPLVLLLVACGRGEVTAQSSSGWDQLVYLFARAI
QWLSFDGSIGVGIILFTLTIRLMLMPLFNMQIKSSQKMQDIQPELRELQR
KYAGKDTQTRMKLAEESQALYKKYGVNPYASLLPLLIQMPVMIALFQALT
RVSFLKTGTFLWVELAQHDHLYLLPVLAAVFTFLSTWLTNLAAKEKNVMM
TVMIYVMPLMIFFMGFNLASGVVLYWTVSNAFQVVQLLLLNNPFKIIAER
QRLANEEKERRLRERRARKKAMKRK
>SPy0395 clpP, putative ATP-dependent protease proteolytic subunit
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLD
AQDNTKDIYLYVNTPGGSVSAGLAIVDTMNFIKADVQTIVMGMAASMGTV
IASSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRHRL
EKILAQNAGKTIKQIHKDAERDYWMSAEETLAYGFIDEIMENNELK
>SPy0101 comYA, putative ABC transporter subunit ComYA
MVQALAKAILAKAEQVHAQDIYILPRADQYDLFLRIGDERRLVDVYQSDR
MAPLISHFKFVAGMIVGEKRRCQVGSCDYKLSKDKQLSLRLSSVGDYRGQ
ESLVIRLLHHQNKSVHYWFDGLTKVANQVGGRGLYLFAGPVGSGKTTLMY
QLISNYHQEAQVISIEDPVEIKNHQILQLQVNDDIGMTYDNLIKLSLRHR
PDILVIGEIRDSQTARAVIRASLTGAMVFSTVHAKSISGVYARLLELGVT
KAELSNCLALIAYQRLLNGGALIDSTQNEFEYYSSSNWNQQIDQLLEAGH
LNPKQAKLEKII
>SPy0102 comYB, putative competence protein, ABC transporter subunit
MEESLLKGQGLADMLSGLGFSDAILTQISLADRHGNIETTLVAIQHYLNQ
MARIRRKTVEVITYPLILLLFLFVMMLGLRRYLVPQLETQNQITYFLNHF
PAFFIGFCSGLILLFGMVWLRWRSQSRLKLYSRLSRYPFLGKLLKQYLTS
YYAREWGTLIGQGLDLMTILDIMAIEKSSLMKELAEDIRMSLLEGQAFHI
KVATYPFFKKELSLMIEYGEIKSKLGAELEIYAQESWEQFFSQLYQVTQL
IQPAIFLVVAVTIVMIYAAILLPIYQNMGGIF
>SPy0103 comYC, putative competence protein
MINQWNNLRHKKLKGFTLLEMLLVILVISVLMLLFVPNLSKQKDRVTETG
NAAVVKLVENQAELYELSQGSKPSLSQLKADGSITEKQEKAYQDYYDKHK
NEKARLSN
>SPy0106 comYD, putative competence protein
MSKQLSNIKAFTLLEALIALLVISGSLLVYQGLTRTLLKHSHYLARHDQD
NWLLFSHQLREELSGARFYKVADNKLYVEKGKKVLAFGQFKSHDFRKSAS
NGKGYQPMLFGISRSHIHIEQSQICITLKWKSGLERTFYYAFQD
>SPy1200 ffh, putative signal recognition particle
MAFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVK
TFIKRVRERAIGHEIIDTLDPTQQILKIVNEELTSILGSETAEIDKSPKI
PTIIMMVGLQGAGKTTFAGKLANKLIKEENARPLMIAADIYRPAAIDQLK
TLGQQINVPVFDMGTDHSAVDIVRKGLEQARENHNDYVLIDTAGRLQIDE
KLMGELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQLSITGVVLTK
IDGDTRGGAALSVREITGKPIKFTGIGEKITDIETFHPDRMSSRILGMGD
LLTLIEKASQEYDEKKSLELAEKMRENTFDFNDFIEQLDQVQNMGPMEDL
LKMIPGMAGNPALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRR
RIAAGSGNSFVDNKFIKDFNQAKSMMQGVMSGDMSKMMKDMGINPNNLPK
NMPAGMPDMSSLEGMMGQGGMPDLSGLGGDMDMSQLFGKGFKGKIGQFAM
KQAMKRQANKLKKAKKKRK
>SPy0569 ftsY, putative signal recognition particle (docking protein)
MGLFDRLFGKKETPKVAEEKLEENLLTETTQKEELSEKANEQDKIEAVQQ
EDVSSEGAGSVENGPEAASVNALVEEETGDNSNHPSEDTNEFAADKTDLK
VSELSQSTASEPKDLVDQPVVEQFPTKQAQADASNDSANEEAVDTSKEQS
SSQQVMEDYYRRKAALEKSLQEKAAATVPVMPEEVPQENQASTSAEASQN
KATHDTIPETDQEKYKRSLKKTRTGFSARLNSFFANFRRVDEEFFEDLEE
MLILSDVGVHVATTLTEELRYEAKLENAKKPDALKRVIVEKLVDIYEKDG
RYNEAINYQDGLTVMLFVGVNGVGKTTSIGKLAYRYKQEGKKVMLVAADT
FRAGAVAQLVEWGRRVDVPVITGPEKADPASVVFDGMEKAVAKGVDILLI
DTAGRLQNKENLMAELEKMGRIIKRVLPDAPHETLLALDASTGQNALSQA
KEFSKITPLTGLILTKIDGTAKGGVVLAIRQELDIPVKFIGFGEKVDDIG
EFHSEDFMKGLLEGIL
>SPy1032 hylA, extracellular hyaluronate lyase
MNTYFCTHHKQLLLYSNLFLSFAMMGQGTAIYADTLTSNSEPNNTYFQTQ
TLTTTDSEKKVVQPQQKDYYTELLDQWNSIIAGNDAYDKTNPDMVTFHNK
AEKDAQNIIKSYQGPDHENRTYLWEHAKDYSASANITKTYRNIEKIAKQI
TNPESCYYQDSKAIAIVKDGMAFMYEHAYNLDRENHQTTGKENKENWWVY
EIGTPRAINNTLSLMYPYFTQEEILKYTAPIEKFVPDPTRFRVRAANFSP
FEANSGNLIDMGRVKLISGILRKDDLEISDTIKAIEKVFTLVDEGNGFYQ
DGSLIDHVVTNAQSPLYKKGIAYTGAYGNVLIDGLSQLIPIIQKTKSPIK
ADKMATIYHWINHSFFPIIVRGEMMDMTRGRSISRFNAQSHVAGIEALRA
ILRIADMSEEPHRLALKTRIKTLVTQGNAFYNVYDNLKTYHDIKLMKELL
SDTSVPVQKLDSYVASFNSMDKLALYNNKHDFAFGLSMFSNRTQNYEAMN
NENLHGWFTSDGMFYLYNNDLGHYSENYWATVNPYRLPGTTETEQKPLEG
TPENIKTNYQQVGMTGLSDDAFVASKKLNNTSALAAMTFTNWNKSLTLNK
GWFILGNKIIFVGSNIKNQSSHKAYTTIEQRKENQKYPYCSYVNNQPVDL
NNQLVDFTNTKSIFLESDDPAQNIGYYFFKPTTLSISKALQTGKWQNIKA
DDKSPEAIKEVSNTFITIMQNHTQDGDRYAYMMLPNMTRQEFETYISKLD
IDLLENNDKLAAVYDHDSQQMHVIHYGKKATMFSNHNLSHQGFYSFPHPV
RQNQQ
>SPy0826 lsp, putative prolipoprotein signal peptidase
MKKRLFVLSLILLVALDQLSKFWIVSHIALGEVKPFIPGIVSLTYLQNNG
AAFSILQDQQWFFVVITVLVIGYAIYYLATHPHLNIWKQLALLLIISGGI
GNFIDRLRLAYVIDMIHLDFVDFAIFNVADSYLTVGVILLLICLWKEEDY
GN
>SPy0856 mur1.1, putative peptidoglycan hydrolase
MKVKKRRRRAKSSVNRLVLGLVLLNLIVSMWTLKLGNQRLAPYADHETLT
FVRKISHAAQSVAQKKQLYSSVMMAQAILESNNGKSQLSQKPYYNFFGIK
GSYKERSVIFPTLEDDGQGNLYQIDAAFRSYGSLTACFLDYARVLNDPLY
DKTHKKFWSHYQDATATLTGTYATDTTYHTKLNELIEWYQLTNFDGLMK
>SPy0857 mur1.2, putative peptidoglycan hydrolase
MTKKKGKLVLISLFVLAACLGAYSAMRQSHKTSNVSAETIASSSTRHFID
EIGPTASTIGQERDLYASVMIAQAILESSNGKSSLSQAPYYNFFGIKGAY
NGSSVTMSTWEDDGNGNTYTIDQAFRAYPSIADSLNDYADLLSSSTYIGA
RKSNTLSYQDATAALTGLYATDTSYNLKLNNIIATYGLTAYDVANSSAQE
TGLATSGYVWNEYRRNYTDAETLAVDEAWAKRMTY
>SPy1805 secA, putative preprotein translocase binding subunit (ATPase)
MANILRKVIENDKGELRKLEKIAKKVESYADQMASLSDRDLQGKTLEFKE
RYQKGETLEQLLPEAFAVVREAAKRVLGLFPYRVQIMGGIVLHNGDVPEM
RTGEGKTLTATMPVYLNAIAGEGVHVITVNEYLSTRDATEMGEVYSWLGL
SVGINLAAKSPAEKREAYNCDITYSTNSEVGFDYLRDNMVVRQEDMVQRP
LNFALVDEVDSVLIDEARTPLIVSGAVSSETNQLYIRADMFVKTLTSVDY
VIDVPTKTIGLSDSGIDKAESYFNLSNLYDIENVALTHFIDNALRANYIM
LLDIDYVVSEDGEILIVDQFTGRTMEGRRFSDGLHQAIEAKEGVRIQEES
KTSASITYQNMFRMYKKLAGMTGTAKTEEEEFREVYNMRIIPIPTNRPIA
RIDHTDLLYPTLESKFRAVVEDVKTRHAKGQPILVGTVAVETSDLISRKL
VEAGIPHEVLNAKNHFKEAQIIMNAGQRGAVTIATNMAGRGTDIKLGEGV
RELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMRRF
GSDRIKAFLDRMKLDEEDTVIKSGMLGRQVESAQKRVEGNNYDTRKQVLQ
YDDVMREQREIIYANRRDVITANRDLGPEIKAMIKRTIDRAVDAHARSNR
KDAIDAIVTFARTSLVPEEFISAKELRGLKDDQIKEKLYQRALAIYDQQL
SKLRDQEAIIEFQKVLILMIVDNKWTEHIDALDQLRNAVGLRGYAQNNPV
VEYQAEGFKMFQDMIGAIEFDVTRTMMKAQIHEQERERASQRATTAAPQN
IQSQQSANTDDLPKVERNEACPCGSGKKFKNCHGRKSFS
>SPy0073 secY, putative preprotein translocase
MFLKILKDALKIKTVRNKIFFTIFIILVFRIGTHITVPGVNAKSLEQLSE
LPFLNMLNLVSGNAMRNFSVFSMGVSPYITASIVVQLLQMDILPKFVEWG
KQGEVGRRKLNQATRYISLVLAFAQSIGITAGFNTLSNVALVKTPDIKTY
LLIGALLTTGSVIVTWLGEQITDKGFGNGVSMIIFAGIISSIPSAIATIR
EDYFVNVKASDLHSSYLIVGILIIAVLAIVFFTTYVQQAEYKIPIQYTKL
MQGAPTSSYLPLKVNPAGVIPVIFASSITTIPSTIIPFVQNGRDLPWLNR
LQEIFNYQTPVGMIVYALLIILFSFFYTFVQVNPEKTAENLQKNSSYIPS
VRPGRETEQFMSALLKKLATVGAIFLAFISLAPIAAQQALNLSSSIALGG
TSLLILISTGIEGMKQLEGYLLKRKYVGFMNTAE
>SPy1281 sipC, putative signal peptidase I
MVKRDFIRNILLLLIVIIGAILLRIFVFSTFKVSPETANTYLKSGDLVTI
KKNIQPKYKDFVVYRVGKKDYVSRVIAVEGDSVTYMDDIFYLNNMVESQA
YLEKMKAHYLNHAPFGTLYTDDFTVATITADKYQKVPKGKYLLLNDNRKN
TNDSRRFGLINASQIKGLVTFRVLPLSDFGFVEVE
>SPy1163 smf, putative DNA processing protein (Smf family)
MNHFELYKLKKAGLTNKNILNILDYQKHQEKSLSLRDMAVVSGCKHPSHF
IEAYKQLDIQNLKMEFKQFPSISILDKHYPMALKEIYNPPVLLFFQGNLD
LLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHL
ACLKNGGQTIAIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPGEEALS
YHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGRDIFAVPGNIL
DGKSEGCLQLIKEGATCVTSGMDILSEY
>SPy1842 spi, putative signal peptidase I
MKQFIKEWGPFTLFLILFGLSRLFLWQAVKVDGHSMDPTLAHGERLIVFN
QARIDRFDIVVAQEEENGQKKEIVKRVIGLPGDTISYNDDTLYINGKKTV
EPYLAEYLKQFKNDKLQKTYAYNTLFQQLAETSDAFTTNSEGQTRFEMSV
PKGEYLLLGDDRIVSRDSREVGSFKKENLIGEVKARFWPLNKMTVFN