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# Streptococcus pyogenes phage 6180.4

>M28_Spy0842 hypothetical protein
MLDSYIKRIVIHQFSPNDTELLLSDRLVSITPRIDEYFRKKLAKVFSDEA
KRGQFEANNTFFTTIGDDLLETSVTIAQLWKEAFVISEDQKTNDLVFVQF
DKDGEPFFAFLRIALKEQFAHLSDNYEHPFTVTQNNLPSPTQTPDEALVI
NLKSGQYYLIEKRVKHNGSFANYFSEHLLKVTPEQSVKKSIKMIEQTAQK
IAEHFNQDDFTFQSKMKSTLFKQLEADDVLSPEKLADQLFDDNLTARLTF
VDQVKDVIPEPIKISDIDHSRQIKKLENQKLSLSNGIELTVPNAIYQDAE
AVEFLLNDDGTYSILIKNIEDIKTK
>M28_Spy1347 two-component sensor kinase
MMSVKTLGRYVTNHFKQGFLINRLMKLYSLLIVSFFTLAAIGLSSYSISS
TYKRVDAEAQMRLEETLGRLQLQNDITLRVLDQLVGRSEDYHNLYQYMTL
TPNQYFSNVFEDWEKGKDTVLFSEEVRRLFDLYPDVTSMTLLLEDSSAYL
YADRVIKTGRLLYSKPEKVTGNVLVRSIRNPESGDVTGRLYLTFDKPPTL
VETQQDHYLATFAFDYYGRKLFHQGGRRFPHLEAEVKKAIKADRAADLSN
LSKAYRMQYNRSGDLLAYVAVRKSYLLAEAVRTVFVYGLVSLLLAWLLLQ
LLFRVFRNYIQQVSEITDTVEMVAAGDLSLTIDNSHMELELYHISEAINQ
MLASIKAYIDEVYVLEVEQRDAQMRALQSQINPHFLYNTLEYIRMYALSC
QQEELADVIYAFASLLRNNISQDKMTTLKEELAFCEKYIYLYQMRYPDSF
AYHVKIDESIADLAIPKFVIQPLVENYFVHGIDYSRHDNALSIKALDETD
HLLIQVLDNGRGISQERLADMEKRLQEHQTTGNSSIGLQNVYLRLFHHFR
DRVSWSMAKEPNGGFIIQIRIRKDV
>M28_Spy1106 GAF domain-containing proteins
MTEAKDSRKKYSNRPRYAIIKGMNKSKKIEQYQLMIAQAKELFANESNAL
ANLSNASALLNMTLPNSVFAGFYLFDGQELILGPFQGRVSCVHIKLGKGV
CGESAQSRRTIIINDVKQHANYISCDAAAMSEIVVPMVKEGHLIGVLDLD
SSLVADYDEVDQEYLEAFVDLFLEKTTFTFNMFGVKN
>M28_Spy0036 protein tyrosine phosphatase
MKKVCFVCLGNICRSPMAEFVMKSIVSSDVMMIESRATSDWEHGNPIHSG
TQSILKTYQINYDITKCSKQITITDFNTFDYIIGMDSDNVKNLKEMSQHQ
WDSKIYLFREGGVPDPWYTNDFEETYQLVRKGCQDWLSRLMSKEY
>M28_Spy0954 histidine-binding protein
MIIKKRTVAILAIASSFFLVACQATKGLKSGDAWGVYQKQKSITVGFDNT
FVPMGYKDESGKCKGFDIDLAKEVFHQYGLKVNFQAINWDMKEAELNNGK
IDVIWNGYSITKERQEKVAFTDSYMRNEQIIVVKKRSDIKTISDMKHKVL
GAQSASSGYDSLLRTPKLLKDFIKNKDANQYETFTQAFIDLKSDRIDGIL
IDKVYANYYLAKEGQLENYRMIPTTFENEAFSVGLRKEDKTLQAKINRAF
RVLYQNGKFQAISEKWFGDDVATANIKS
>M28_Spy1444 PTS system, galactose-specific IIA component
MFPNILFTEARTQPELFDLVASYLEKVGYVTQEYHQALVEREAVFPTGLK
VDLKDGSDILYAAIPHTETKYCLVDQVVYVRNSQALTFKHMINPEEDCLV
TDFFFIINSQNEGQTTILSNLITFFITKGNLSYLASLKDDKQAISNYLIE
KGVFQHD
>M28_Spy1218 two-component sensor kinase
MKRYPLLVQLISYVFVIVIALITTLGLLYYQTSSRNIRQLIERDTRQSIR
QSSQFIDAYIKPLKETTSVLAKNTEIQAFASQIHQENDKQVLQLMKMVLA
TNSDLQAAVLVTKDGRTVSTNSQLTMKTSSDMMAEPWYKAAIDRQAMPVL
TPARQLSLSSKKEWVVSVTQEVVDRAGHNLGVLRLDIAYPTIKASLDQLQ
LGRQGFAFIVNDKHEFVYHPKKSVYSSSKEMAAMKPYLAIQNGYTKDKTS
FVYQKLIPNSQWTLVGVASLDQLHRVQRQIFWSFLGTGLLACLICGFATV
LALRRWIRPIQQLQQVILAIQKGDRQLRAQETGSPELTNLAQQFNALLDQ
IDSLMVAVADKEKAIGQYRLQALASQINPHFLYNTLDTIIWMAEFNDSKR
VVEVTKSLAKYFRLALNQGNEYIRLADELDHVSQYLFIQKQRYGDKLSYE
VQGLDVYADFVIPKLILQPLVENAIYHGIKEVDRKGMIKVTVSDTAQHLV
LTVWDNGKGIEDSSLTNSQSLLARGGVGLKNVDQRLKLHYGEGYHMTIHS
QSDQFTEIQLTLPKMHELMADDTQENE
>M28_Spy0262 ABC transporter substrate-binding protein
MIKKQYLGRATIALASTLVLAACGSSKTAESGNQGSSKEVLFATVGTTAP
FSYEKGGQLTGYDIEVAKAVFKGSDDYRVSFKKTEWSSIFTGLDSGKYQM
GGNNISFTKERSAKYLFSYPIGSTPSVLVVPKDSDIKSFDDIQGHTTQVV
QGTTSVAQLEDFNKKHSDNPVTLKFTNENITQMLTNLSEGKADFKIFDAP
TVNAIIKNQGLDNLKTIELTSTEQPFIYFIFSQDQEKLQSFVNKRIKELT
ADGTLSKLAKEHLGGDYVPSDKELKLPTAN
>M28_Spy1337 transcriptional regulator, AraC family
MVTHMIDSLLLKSLHSLLGLTITVCDQNFSVIREYKSDKTISLFYNHYLI
LSNFSKTQHDFLFHYGSLGELFLVHHIQQYYIIIGPWRSNAIDPLLLKKK
LTETQINASEQDYFIDRLSQLPFFSLSQIRELLIVTNYCLTGVVKDKLSE
PLHYYTKGWSNSFDLDKIKQFSKQNMSSYKYQYHFENNILKAVKSGSEFL
LKETVEHFSNSIVPIISGDELRSEKNYSIIIYDRLSQATIQAGLDIETAY
RARDRFIKETESTISLNEVLKLRDTAILFYTQQVDSLKRHLETPHSQTIV
AVIRYLENNLNRFIKTEEIAKECHMSESKLRKLFKQEKHITIQQYFINLK
IEAAKQLLDENKKVEEVSNLLGFSTSSNFSRTFKKIVGISPLEYKQKLKT
I
>M28_Spy0660 two-component response regulator
MKILLAEDEWQMSNVLTTAMTHQGYDVDVVFNGQEAIDKAKDNAYDIMIL
DIMMPIKSGIEALKEIRASGNCSHIIMLTAMAEINDRVTGLDAGADDYLT
KPFSLKELLARLRSMERRVESFTPQVLQFAGVTLNINEQELSAGNAIRLA
SKEGKLMAFLMLNQGKYLDTKTLYQHVWSDQEDYDTSIVWVYISYLRQKL
LAIQANVIIAGDKDTSYCLLEK
>M28_Spy1503 universal stress protein family
MDRFQNDSKKSIMKKRIKAILVKLLKEDSSMSLKYKRILVAIDGSYESEL
AFNKGVNVALRNDATLLLVHVIDTRALQSVATFDTYIYEKLEQEAKDVLD
DFEKQAQIAGITNIKQIIEFGNPKNLLAHDIPDRENADLIMVGATGLNTF
ERLLIGSSSEYIMRHAKIDLLVVRDSTKTL
>M28_Spy1219 two-component response regulator
MYSLLIVEDEYLVRQGIRSLVDFSQFKIDRVNEAENGQLAWDLFQKEPYD
IVLTDINMPKLNGIQLAELIKQESPQTHLVFLTGYDDFNYALSALKLGAD
DYLLKPFSKADVEDMLGKLQQKLDLSKKTETIQELVEQPQKEVSAIAMAI
HERLADSDLTLKSLAQQLGFSPNYLSVLIKKDLGMPFQDYLVQERLKKAK
LLLLTSNLKIYEIAEQVGFEDMNYFSQRFKQLVGVTPSQYKKGGQA
>M28_Spy0762 two-component response regulator
MYKLVIIEDEHIIRKWLRYAIDYKALDILVIGEAKDGKEGAVLIKESQPD
IVLTDINMPIMTAFDMFEATKDQTYAKIILSGYADFPNARSAIHYGVLEF
LTKPIEKAALWECLQTIIAKIEKQKGSNQKTDACVYIPLPQMTDQIPEVV
KDILEWVHAHFQDKISTSRLAHDLGYSESYIYQNIKKHLQMPLSDYINQY
RINQAIQLMQQEPDLMVYEIAQAVGIYDYRYFDRVFKKYLGQTVKAFKEE
HFMKDTDRSKPC
>M28_Spy1869 phosphoesterase, DHH family protein
MEALYFRAFLWYNVCLRGYKMKKFRFETIHLIMMGLILFGLLALCVSIMQ
SKILILLAIFLVLLFVVALLWYQKEAYHLSDLAHIELLNEQTEDNLKTLL
DNMPVGVVQFDQETNAVEWYNPYAELIFTTEEGFIQNSLIQQIITEKRRE
DISQTFEVSGNKYTSYIDVSSGIFYFFDSFVGNRQLADASMLRPVVGIIS
VDNYDDITDDLSDADTSKINSFVANFIDEFMESKRIFYRRVNMDRYYFFT
DFKTLNDLMDNKFSVLEEFRKEAQDAQRPLTLSIGISFGEENHSQIGQVA
LENLNIALVRGGDQIVIRENADHTNPIYFGGGSVSTVKRSRTRTRAMMTA
ISDRIKMVDNVFIVGHRKLDMDALGSAVGMQFFAGNIIENSFAVYNPDEM
SPDIERAIERLQADGKTRLISVSQAMGLVTPRSLLVMVDHSKISLTLSKE
FYEQFQNVIVVDHHRRDDDFPDNAILTFIESGASSAAELVTELIQFQNAK
KRLNKIQASVLMAGIMLDTKNFSTRVTSRTFDVASYLRSKGSDSVEIQNI
SATDFEEYKQINEIILQGERLGDSIIVAAGEKNHLYSNVIASKAADTILS
MAHVEASFVLVETASHKIAISARSRSKINVQRVMEKLGGGGHFNLAACQL
TDISLPQAKHLLLKTINMTMKETGEVES
>M28_Spy1204 ATP-dependent protease La
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGK
EDKRKGAYQFVAVGISRASLAQLLYAWLTPFTEISTAEDTTGGYSDTDFL
RINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHL
ADTVTGVNGKQFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIK
LKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMFTLDIYDQITK
EDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVD
KEIKKVNPNAISNYEEAKRAAKRLKTKMKIVPVTTVQEALVYLRK
>M28_Spy0230 ABC transporter amino acid-binding protein
MKQETYMKKLILSCLVALALLFGGMSRAQANQYLRVGMEAAYAPFNWTQD
DASNGAVPIEGTSQYANGYDVQVAKKVAKAMNKELLVVKTSWTGLIPALT
SGKIDMIAAGMSPTKERRNEISFSNSYYTSQPVLVVTANGKYADATSLKD
FSGAKVTAQQGVWHVNLLTQLKGAKLQTPMGDFSQMRQALTSGVIDAYIS
ERPEAMTAEAADSRLKMITLKKGFAVAESDAAIAVGMKKNDDRMATVNQV
LEGFSQTDRMALMDDMVTKQPVEKKAEDAKASFLGQMWAILKGNWKQFLR
GTGMTLLISMVGTITGLFIGLLIGIFRTAPKAKHKVAALGQKLFGWLLTI
YIEIFRGTPMIVQSMVIYYGTAQAFGISIDRTLAAIFIVSINTGAYMSEI
VRGGIFAVDKGQFEAATALGFTHGQTMRKIVLPQVVRNILPATGNEFVIN
IKDTSVLNVISVVELYFSGNTVATQTYQYFQTFTIIAIIYFVLTFTVTRI
LRHIERRFDADTYTTGANQMQIAEVSNV
>M28_Spy1812 phage protein
MSKKNAIRKLKEFHRWQRIANSLDLTYTELYQFDIEYHPTRRKHLEISRE
CALEELDAIRYAINQLSKVEYRQILIECYLISEEKTQQDIMEELNRSQSW
YYESKKRALLEFVEFYRDGALKNNVRL
>M28_Spy1064 transcription antiterminator, BglG family
MLSKKELAIITFLIHHKEQFVSSATLAEVIGMSDRTVRKYLKELISSLPE
HGAHIISKQGRGYCLEIDHSMAFDIFWQESVTSKKRLADVTQVEESVDRE
DYVLHKFFFEDAVQDFEELCQELYISRTTLKHVLAGIKERIIPYQLELEI
THQHIQIRGKEEDIRHFIMDYFFVTSFDNTLSTMVGNTFLEGINFAEIMI
IVLDECRDAKLKLSDFVMNNLVLHIALMVQRIRSGCPLELFSIPIAIRQS
DEYQVALRILYRVEEVMGIRFPKEEANYIALHLKVKHSVGKHWQDDNTDE
KLQDHLKACIAKISQLTGMTLETDTNLFQGLLAHMMPLTTRLENHIQLTN
PLTEEIKSQYPEIFTLTKQTFSDLLVCQKNDVSDDEWAYISLHLMAAIER
YSNRHKLRVLVVCATGYGSAMMLKNRLEKEFEGRLRIVDVISYYEITEER
LKTVDLIISSISLANLMFLTPVITVSVFLSNQDIETIRQFIGEQEGIKKE
VSLPSQMSLAKAEQLLTGVFSPNRFLYLDEKISKEDLLLRMIACLDEAGT
ETFVEDFYHQMVLRENYSPVIYGEVLAFPHPANPMTYSEQVVVAICREPL
EWDKAHQAVHFVFLLSPSKGHNHRLKYVSPGLASFVNQVELQQALLEEPN
YSKFMTVFTPLIHD
>M28_Spy0575 arginine-binding protein
MTKRNKYTMNFKKIRFGFLLCLLLYPLAACNKSEQLNHYERIKKTRKLVV
AVSPDYAPFEFKALVNGKDTIVGADVQLAQAIADELDVDLELSPMSFDNV
LSSLQTGKADLAISGISHTKERAKVYDFSIPYYQAENAIVMRASDAKVTK
NISDLNGKKVAAQKGSIEEGLVKIQLPKANLISLTAMGEAINELKAGQVY
AVTLEAPVAAGFLAQHKDLALAPFSLKTSDGDAKAVALPKNSGDLTKAVN
KVIAKLDEQERYKSFIAETIALTKNTMK
>M28_Spy0390 hypothetical protein
MHRLPNRLIPEEDNNKLSRVAKEVVTEPRLNNPFLLPKKVLSLEDDAAIL
NHLEEDRNVNKLFLEPVAAEAKREINFHPSDQQVTAKVKESSDFHQKQHQ
TGITYGDDTLADLTHHLLHSDGVIPSLNDKSA
>M28_Spy1228 phage protein
MIDFVQIGAFCGAALSILGVWGFIVNPFKKAMEANEFAMAQLKDSIKELA
YELKNLDRDREITKKIIDRHEERLGRVEDEVIINKERIVTLFKKGEEK
>M28_Spy0148 PTS system, 3-keto-L-gulonate specific IIA component
MNLKQAFIDNNSIRLGLSADTWQEAVQLAVQPLIDSKAVTSAYYDAIIAS
TEKYGPYYVLMPGMAMPHAEAGLGVNHNAFALITLTKPVTFSDGKEVSVL
LTLAATDPSIHTTVAIPQIVALFELDNAIERLVACQSPKEVLEMVEESKN
SPYLEGLDLDS
>M28_Spy0661 two component system histidine kinase
MFIRKIGGDMFNRIRIRFIMIASIAIFIILSSIVGIINTARCYQSQQEIN
RILHLISSNKGKLPGTTESSKRLGTKLSEDSLSQFRYYSVIFNANGHLLS
SNTANISALDREEAQYFARLFAKSGEEKGSYRHQDSVYSYLITQLPNEEK
LVVILDTTFYFRSVGDLLAVSVMLAFGGFIFFVVLVSLFSGMVIKPFVQN
YEKQRRFITNAGHELKTPLAIISANNELVELMTGESEWTKSTSDQVKRLT
GLINQMITLARLEEQPDVVLHMVDFSAIAQDAAEDFKSLVLKDGKRFDLT
IQPNIMIKAEEKSLFELVTILVDNANKYCDPKGLVKVSLTTIGRRRKRAK
LEVSNTYLEGKSIDYSRFFERFYREDESHNSKEKGYGIGLSMAESMVKLF
KGTITVNYKNDAIVFTVVI
>M28_Spy1616 sensory transduction protein kinase
MIRIKNITKSKFFGTAIILLQQLIALLILVYNRENLSLLFSEKVALVMTL
IDTAFIWLATILRQKQGDIFKRIISIISLTIWQYLVSVLTRGTPLFLSSG
LQIILLYCYTVEITNLILYGHKQFKDKLDKGLLIIIFVSITSLFVNSILF
NFLFLMVFTILHLYPLLVIVLYYRSFRQQISVVRRSLILFSLLLLVILGS
ELYGEMLDVNQAFNNLGWYLFPLIMSVIYYFKTIHDKLSFVTQRWLGDYK
ARIELLFLLLILCWIVLMKVLVKDFLLFFIVVDASTLFCLVVISCIFYYL
KDSKQNFDYENRRLNYFMKSEENMRVEFSNYLHDDVLQNIIAIKNLLSLE
NSNITHGFIVNELNDLVSGIRDEMDTYYPIVPANQTMKENIQSLFDDIVK
SRKSNTLLYFNCSDNMVVPSPYGDIVYRFIKELINNAIKYGDGKDIRLSL
TIQSDIIIIEESNQVVEKVHSISYGRGLKSFQETLAAFDGDLELQMDTKQ
FTIRILLPIDWKLCYEDFIN
>M28_Spy1214 transcription regulator, crp family
MIRREDYQYLRKLNDFRYFSIEQFDKIVGQMEFRKAKKDHILFFEGDKRD
KLFLVTSGYFKVEQSDQSGTFMYTDFIRHGTIFPYGGLFTDDYYHFSVVA
MTDVTYFYFPVDLFEDYSLENRLQMKHLYSKMSKLLELHELRVRNLITSS
ASSRVIQSLAILLVEMGKDSDTLPFQLTTTDIAQISGTTRETVSHVLRDL
KKQELITIKGKYLTYLDKDYFLQYTK
>M28_Spy0434 hypothetical membrane associated protein
MFMMDKTVLYFGLVEISFDVPDFIFQKIKEQNNKIRYYSKSINILGSVKF
INSNQQLIEYDGNGNILVYGRLKYFKEGISLYYIGEYLAECLLIEHSDTL
LIHAAAVYNPLSGHSILLLGDKGAGKTTVAIRLCIEHGYHLIGNDQVIFG
SNSGILLTYAGTSFFKIRRTAVLSDNLLFKLFSKFFNRSLQFNKASWDDK
ISIFPKELGIRTCNFSTEISKIYYIKTDKKEKQIYHSIWSDSLASLYLNE
LLGRHISGQVACFQSDNGKYFSTMPLINYEKNNRVREQIVKGIFAKQKLF
KITAATPAKIAEAIIENVKKNS
>M28_Spy0761 two-component sensor kinase
MRGEQVEEHFKKQLQDDISRHFSYQSLMLSLLLIGLFIIFSLAPQQLGLY
RDINATATRYHRLISKQEALLDDLGKNSLLPFLNKNLSTADLSKHYFHLR
HSSQTSPELLLFSPSQDLLFASNPHLGNVFSKSVYIQEVLRAAHPPKTLF
KVAMDSEDGHYLMIIKPMIDQNQLKGYAFLVMSGKDFLHPTKTLTSELVI
ADKLDNTFTFSNREFIASSLDKINSQYLHHYFVFQDNRAFITRKVALQGG
LWLYMYRPLIPMVSVMLFSLISSAVIFVILQRKSSGLANRIAAKNSRAIN
QMVRDMSAISRQEKRRIDLESQDEFQYLSDQINQMVERLQQLHDKTLDLE
TQKLLFEKRMLEAQFNPHFLYNTLETILITSHYDSALTEKIVIQLTKLLR
YSLTDSSKPVLLKDDLSVIESYLVINQVRFEELQYSINLSPDLDSLAVPK
LFLLPLIENAIKYGLKERHDVKINIACYYQDDHIIFSVRDNGSGIDAHHQ
KVIREQLEAGESHHGLINSYRRLKYHFSEVSLVFDQGDKQFNVSYHVKE
>M28_Spy1562 universal stress protein family
MALFLVGTIGLSTFRYMTIGLTSEYRLCHVKIDLLIVRANKKCYNTMK
>M28_Spy0852 hypothetical protein
MLKKCLTIVKHRLKESRSTMTKKNHGVFWGLLLGSAAASIAYLSLSSSKK
DQLLKDSAKKIDDLNAYLQDKSKQVLDAVSEKVQESKDAVEVYGGIAAET
VEEKWQDTKDAVEVYGGIATETVEESLGQVKEKVEGIGEATSQTIQSKME
KLTSDKTDADDEK
>M28_Spy0992 phage protein
MNKRIKKKRKLETAVVMLVAENAIQAKALRNQNKQIAELRAIIQQNVQAI
NREFVTAKNTILDNQLAIKLIGDDVGHIKQNYKRKWRK
>M28_Spy1299 hypothetical cytosolic protein
MAKQKNRKKALKLEMKRNGLLKKAGQVFDKAVESVETAVDKTISAGKNLV
EKGSQTVENLTASKERLTLDEFAGQPVVAGIRSDLVETLYAEGIHSAQAF
KEWTEKDLLALKGIGPATVKKLVENGASFKK
>M28_Spy0995 phage protein
MTTRKSKYWRDRIKKEMDAKEADDISLEQSMKQLHDYHFRNIEKEIESFY
QRYADKEKIDLSEARKRASELDISAYQKKAKELIAKAEKLRKEGRTVTKA
DFTHQENADMAIYNLAMKTNALELLRLNIDLEMQELANGEHKLTKKFLDE
GYRKEVEFQAGLLGLSVASQANVKNLADAVINANFKGAKWSDNIWDRQDK
LRSIISQSVQSAILKGKNGLTIARDIRREFDVSASYAKRLAITEHARVQM
EVGRLSMAENGFAMFDILPEPKACDVCKDIAKHGPYHLDKWRIGENSPPF
HPYCRCAVVGLDKKQEEKVNDKSEKFENITPNLMPLFSKFASKITDLQRK
IVYSADLADTGYIRTPHAFDINNTLRNKGYNYLNVDDKLITDTLDSVISI
NSTPKNIKVYRFDDFELLGSINEQNNNIFDSGNFMDKLNQGGLSYTNDGY
TSASYDVKKNVMGYRPIKTEIKVPKGSHVYLTDNEEESEIILPRGTKYDI
INAKINEYEEIEITMEIRKE
>M28_Spy1346 two-component response regulator
MYKVLLVDDEYMILQGLTMIIDWQALGFDVVSTARSGQEALAYLTQYPVD
VMISDVTMPGMTGLDLIEAAKTNHPQLQTLILSGYQEFSYVQKAMELETK
GYLLKPVDKAELQAKMKQFKDWLDAQQAESIRQETYHDSLLTLWLTDELS
EKEFHQLSQDLPEHALTGFTVLYVECSEWIEEMEAYFKQEEQPCYLKKEE
DKKIYLAILLGRAQQAKAFTSNLQKQFSENIQQIILGETVDDWENVYESY
NQVRQSLFYNSQMSQPTDKGNSKLEMPESRLQFFAFNKALMIGDEPTILA
KLEAIFHEMKALNFSPEDVKHVSFLLFSDIYRQFPILDKMTYLSMVKTIH
NSQSIDRILRELKKVLDVTNQNNSPEKRYSDLVSETIDCIRKEYHQELTL
KAIADRLHVNGVYLGQCFKNETERSFTQYLNHVRIQKAQQLLLYTNQSIN
EIAYETGYNTNHYFIKMFKKLNGLSPKEFRDRYKDNYQAIKGDQ
>M28_Spy0464 stress-responsive transcriptional regulator PspC
METKFYKQRKNRLVAGVIAGLADKYGWDLALARVLAALLIYGTGFGVLLY
ILLAIFLPYKEDLLEERYGRGPRRRKDADVLNEEEDGWFW
>M28_Spy0112 transcriptional regulator, AraC family
MVIFDLKYVQTLHSLSQLPISVMSQDKALIQVYGNDDYLLCYYQFLKHLA
IPQAAQDVIFYEGLFEESFMIFPLCHYIIAIGPFYPYSLNKDYQEQLANN
FLKHSSHRSKEELLSYMALVPHFPINNVRNLLIAIDAFFDTQFETTCQQT
IHQLLQHSKQMTADPDIIHRLKHISKASSQLPPVLEHLNHIMDLVKLGNP
QLLKQEINRIPLSSITSSSISALRAEKNLTVIYLTRLLEFSFVENTDVAK
HYSLVKYYMALNEEASDLLKVLRIRCAAIIHFSESLTNKSISDKRQMYNS
VLHYVDSHLYSKLKVSDIAKRLYVSESHLRSVFKKYSNVSLQHYILSTKI
KEAQLLLKRGIPVGEVAKSLYFYDTTHFHKIFKKYTGISSKDYLAKYRDN
I
>M28_Spy0972 phage protein
MIDFVQIGAFCGAALSILGVWGFIVNPFKKAMEANEFAMAQLKDSIKELA
YELKNLDREREITKKIIDRHEERLGRVEDEVIINKERIITLFKKGEEK
>M28_Spy0686 cystine-binding protein
MLYYSYLNKGVTMKKSVTLLSIGLASLLLAACAPHKSQKSSWETIKEKGV
LKVATPGTYQPTSFYNDNNELVGYEVDMVKEIGKRLNIKVKFVETGFDQA
FTSVDSGRVDISLNNFDITPKRQKKYNISTPYKYGVGGMIVRADGSSNMA
KKDLSDWKGKKAAGASGTEYMKVAQKQGAELVTYDNVTGDVYLNDVANGR
TDFIPNDYPAQKLFVDYMLSQNPNLNVKMSDAQYNPTEQGIVMNKKDDSL
KKKIDAVIKDMIKDGSLKKISETYYAGQDLTKPFGKDKKIPIIDTKDVN
>M28_Spy1336 R28 protein
MFRRSKNNSYDTSQTKQRFSIKKFKFGAASVLIGLSFLGGVTQGNLNIFE
ESIVAASTIPGSAATLNTSITKNIQNGNAYIDLYDVKNGLIDPQNLIVLN
PSSYSANYYIKQGAKYYSNPSEITTTGSATITFNILDETGNPHKKADGQI
DIVSVNLTIYDSTALRNRIDEVINNANDPKWSDGSRDEVLTGLEKIKKDI
DNNPKTQIDIDNKINEVNEIEKLLVVSLPDKIKYSPEAKHRTVEQHAELD
AKDSIANTDELPSNSTYNWKNGHKPDTSTSGEKDGIVEVHYPDGTVDDVN
VKVTVTSKKTDNTAPTLTVTPEQQTVKVDEDITFTVTVEDENEVELGLDD
LKAKYENDIIGARVKIKYLTKEPNKKVMEVTIMKATLADKGAITFTAKDK
AGNQAEPKTVTINVLPLKDSNEPKGKDQTVKVGETPKAEDSIGNLSDLPK
GTTVAFEAPVDTATPGDKPAKVVVTYPDGSKDTVDVTVKVVDPRTDADKN
DPAGKDQTVKVGETPKAEDSIGNLSDLPKGTTVAFEAPVDTATPGDKPAK
VVVTYPDGSKDTVDVTVKVVDPRTDADKNDPAGKDQTVKVGETPKAEDSI
GNLSDLPKGTTVAFEAPVDTATPGDKPAKVVVTYPDGSKDTVDVTVKVVD
PRTDADKNDPAGKDQTVKVGETPKAEDSIGNLSDLPKGTTVAFEAPVDTA
TPGDKPAKVVVTYPDGSKDTVDVTVKVVDPRTDADKNDPAGKDQTVKVGE
TPKAEDSIGNLSDLPKGTTVAFEAPVDTATPGDKPAKVVVTYPDGSKDTV
DVTVKVVDPRTDADKNDPAGKDQTVKVGETPKAEDSIGNLSDLPKGTTVA
FEAPVDTATPGDKPAKVVVTYPDGSKDTVDVTVKVVDPRTDADKNDPAGK
DQTVKVGETPKAEDSIGNLSDLPKGTTVAFEAPVDTATPGDKPAKVVVTY
PDGSKDTVDVTVKVVDPRTDADKNDPAGKDQTVKVGETPKAEDSIGNLSD
LPKGTTVAFEAPVDTATPGDKPAKVVVTYPDGSKDTVDVTVKVVDPRTDA
DKNDPAGKDQTVKVGETPKAEDSIGNLSDLPKGTTVAFEAPVDTATPGDK
PAKVVVTYPDGSKDTVDVTVKVVDPRTDADKNDPAGKDQTVKVGETPKAE
DSIGNLSDLPKGTTVAFEAPVDTATPGDKPAKVVVTYPDGSKDTVDVTVK
VVDPRTDADKNDPAGKDQTVKVGETPKAEDSIGNLSDLPKGTTVAFEAPV
DTATPGDKPAKVVVTYPDGSKDTVDVTVKVVDPRTDADKNDPAGKDQTVK
VGETPKAEDSIGNLSDLPKGTTVAFEAPVDTATPGDKPAKVVVTYPDGSK
DTVDVTVKVVDPRTDADKNDPAGKDQTVKVGETPKAEDSIGNLSDLPKGT
TVAFETPVDTATPGDKPAKVVVTYPDGSKDTVDVTVKVVDPRTDADKNDP
AGKNQQVKGKGNKLPATGENATPFFNVAALTIISSVGLLSVSKKKED
>M28_Spy1652 transcription antiterminator, BglG family
MSPIAVKNDYGQLDSICLENENASFYTDIIGGDDMLSHELIRNYQLFSKY
KGHSLEAFESILKTSKRHILADIAKINDTLSLYQLPLIALDRQLVYPPDL
TEKDLLNRMLPTLDDYLFQDERLDMIIIYIMMAKEFISINHLESLLRLSR
NSVIADLNLVRDRVQAFQVTLAYNRQDGYFFEGEPLALRRLLESAVSSLL
QVTSGPWVFSYLLHELGLPDQTKVMAATLEELSRENHLTFISEKLRDLIY
FFCLLAHRPFSRNVRAEVVDTFPLASPAVETMVDQLLVNFPSLTEEKYLV
QSRLLGCIQGDLELVFQQPIYDIMEEIINSVAVNTGLSITDTPELRQNLY
SHLLPAYYRLYYDINLTNPLKEQIKQDYESLFYLVKRSLSPLEKQLGKPV
NEDEIAYFTIHFGRWLQAPKKRPSNQLVALSVCPNGISSSLMLEATLKEL
FPQLQFIRIHQLDKIKLLDPASFDLIFSTVAFDCVKPVYVTQALMGPVEK
MMLKKMVCDDFHLPLSEQFALDDLLSIIHKHTTITNKEGLVSDLSRYLFG
NHLTIEKGGLGLLDLLTADFIRQADAVSDWQEAIRLAAQPLLEHQMIETS
YIDGMIDSVNELGAYIVLAPKVAVPHAAPEKGTRQLGMSLLQLKEPVSFD
LKQEGDPDKQVQLIFVLSAVDSSSHLKALQELSLILDDDEHIEQLIEAKN
TEEIMSLISHMIEKGDESHD
>M28_Spy0953 cfa, cAMP factor
MKPKHLLCLSTVVAGLALFSTMTHSVLADDASNPDTILMNNNQANLQRDA
LVQKLDEGHQQLEAIKHEAKGTDIEATVNKAIDAVDHMKSSIRFNTETIY
DFSSIGARVEALSDAIKAIVFSTTQLTHKVEKAHTDMGFAITKLVIRIID
PFASVDAIKAQVQEIKALEEKVINYPDLQPTDRATIYTKAKLNKAIWNTR
LERDKKVLGIKSFDVYNRLNKAITHAVGVQLNPTTTVQQVDDEVIAVQNA
LETALKS
>M28_Spy0919 ciaH, sensor protein
MNKLKKEILSDNYNHFFHFFAVFTGIFVIMTIIILQIMRFGVYSSVDSSL
VSVSNNASSYANRTMARISSFYFDTENNIIKALPDSDSSKLLGTPAANTD
IILFSANGTILNAFDAFSNYQNFHLDKRRLGSIETTSLMNFYGQEEKYHT
ITVRVHIKNYPAVAYMMAVVNVEQLDRANERYERIIIIVMSVFWLISILA
SIYLAKWSRKPILESYEKQKMFVENASHELRTPLAVLQNRLESLFRKPNE
TILENSEHLASSLDEVRNMRILTTNLLNLARRDDGINPQWTHLDTDFFNA
IFENYELVAKEYGKIFYFQNQVNRSLRMDKALLKQLITILFDNAIKYTDK
NGIIEIIVKTTDKNLLISVIDNGPGITDEEKKKIFDRFYRVDKARTRQTG
GFGLGLALAQQIVMSLKGNITVKDNDPKGSIFEVKL
>M28_Spy0920 ciaR, transcriptional regulatory protein
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILL
DLMLPEKNGFQVLKELREKDIKIPVLIMTAKEGLDDKGHGFELGADDYLT
KPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVEL
LGKEFDLLVYLLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKK
LKGTRFVNRLQTLRSVGYILKNNE
>M28_Spy0274 covR, response regulator
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLI
LLDLMLPEMDGFEVTRRLQTEKTTYIMMMTARDSIMDVVAGLDRGADDYI
VKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGD
DEISLTKREYDLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIR
YLRGKIDIPGKESYIQTVRGMGYVIREK
>M28_Spy0275 covS, CsrS
MENQKQKQKKYKNSLPKRLSNIFFVLFFCIFSAFTLIAYSSTNYFLLKKE
KQSVFQAVNIVRVRLSEVDSNFTLENLAEVLYKNDKTHLRIDDRKGSRVI
RSERDITNTLDANQDIYVYNIDKQMIFTTDNEESSPGLHGPIGRVYHDHI
EDQYRGFSMTQKVYSNRTGKFVGYVQVFHDLGNYYVIRARLLFWLLVVEL
FGTSLAYLIILITTRRFLKPLHNLHGVMRNISENPNNLNLRSDISSGDEI
EELSVIFDNMLDKLETHTKLQSRFISDVSHELRTPVAIIKGHIGLLQRWG
KDDSDILEESLTATAHEADRMAIMINDMLDMIRVQGSFEGHQNDMTVLED
SIETVVGNFRVLREDFIFTWQSENPKTIARIYKNHFEQALMILIDNAVKY
SRKEKKIAINLSVTGKQEAIVRVQDKGEGISKEDIEHIFERFYRTDKSRN
RTSTQAGLGIGLSILKQIVDGYHLQMKVESELNEGSVFILHIPLAQSKES
>M28_Spy0807 dpiA, transcriptional regulatory protein
MNVLIIEDDPMVDFIHRNYLEKLNLFDRIISSDSMKAVQSILTDYAIDLI
LLDIHITDGNGIQFLEKWRAQHIPCEVIIISAANDGNIIRDGFHLGIIDY
LIKPFTFERFQESIQQFVTHREHLANQQLEQAQIDQLKCLTSKKDTKNKQ
LLEKGLSESTFQWIIENIKAFDQPFTIQELASACHLSHVSVRKYIAYLEE
NKQLNSQQIFTKVGRPYRVYW
>M28_Spy0808 dpiB, sensor kinase
MKKPLRLWASLSLILVSMIVVTTSLFYGIMLHDTHQSIKNQETHLLTSTG
KMLASHQAIKELLLNNQPNAKTTAYTNSIASIYNLDYVVVMNMKGIRLTR
PNPKNIGKPFQGGDEEAVLAGKKVISTAKGTLGKSLRYLVPVFDGDKQIG
AIAVGIKLTTLNDVALTSKRNYTLSLFLCLLISLLVTSFISFRLKRQLHQ
LEPSEIYQLFEERNAMLDQIEAAVFVVDKTGILQLCNQAGQELIARKCQL
GKPTGNSFNHLFPDFPKLSLQEGHEQLFRYGEEDYLLAISPICVKNDHRG
HIIFMREAVKAIDTLDQLAYTTAYASALQAQTHKFMNQLHVIYGLVDIAY
YDQLKIYLDSILEPENEILTSLSVLVKEPLLASFLIGEQEKYQELNVHLK
IDVLSEIPHSVTKNQLNNGLMIYRFIHTNLLTTLRPKSLVLSIQHDQNHL
ISHYTLTDNWIDLERVQPIFDLPYFQQLLTDTNSQFHQHQTVTELQFSVT
TPYVGWQHERFNH
>M28_Spy0200 fasA, response regulator
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQE
RGDHQLYFLDIEIGEYTRCGLELAAAIRQKDPNAVIVFVTTHSEFAPISF
KYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQT
RLKLPYKDILYFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCH
RSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFERWEALR
>M28_Spy0198 fasB, sensory transduction protein kinase
MANSEYMFLLLSIIVYYMTKIYIFSFLSDITLPVWKQLTILALALFFNQF
PYLSPLLIDPLLFLVVLRQETKQLFSLKALFLAVAPSVLVDLLSRFMGTI
VIPYLFLSSGIYLGHIIFDLLAYLLIFPSFAIINYMIGKDYKMICQSGYS
KRSHNFYQTLLIFVLVYYVDIFVILGFTDPFLHFHHSLFVPTPYKLLFLM
FILLLVYLLSYFNHSSKEYLKNELRREQQAYMTNLETYGKHLEKLYRDVR
AFQSDYLSRIERLGQAIKSESITQIQDIYAQTVHEANDYWDDKHYNISKL
RKINISSIKSLLSAKIISAEKSGIDLNVEVPDNIKETYIPELDLLLLMSI
FCDNAIEAALEAQQPHMSIAYFLLDDYQMFVVTNTTKKKVDINKIFEEGY
SSKGSERGIGLSNAQRILKKYPYLSLRTKSFDKEFSQTLTMPKEEVDR
>M28_Spy0199 fasC, sensory transduction protein kinase
MMVIYSMALFYATIFINSWVIFAKVSAIKLSWKRVSVIGISFVIANMIFD
KVILIDQLFFIIVSLLSAPKKKLFEHMFNGFFTILIVELLFRVIGSFFLP
AVLGFSIGQINNNLKLLELCYLFVLPIFYLFSYIFSIDLSLIRFISEDKM
KKWVFWMNTAMFSYYFFAHFLVTVQSGFLALYFQYRSILVFIYLAIFIWV
IVKLDRFAKDQLSQKLTQAQNERIAYLENYNQSIEQLYREIRTVKHDSEN
ILISLKDSIDSGDIDLITRVYDTVIQQSATSMMRTNYEISSLDNIKEAVI
RSIMNSKLLEAQYLGIELYIEIPDVIDHLPIKLIDLIVLFTGLVDNAIET
AKGSRRPFLSIAYFKQDNKQLFIIENSTKTNRVDIAKRFDAQQQNSAHFL
TVLDSYPQITLSTKSDHYRLRQLLEMR
>M28_Spy0643 fruA, PTS system, fructose-specific IIABC component
MKIQDLLRKDIMILDLQAISKEVAIDEMITKLVEKDIVHDFDVFKKSIMT
REEQTSTGLGDGIAMPHSKNIVVDKPAVLFAKSNKGVDYKALDGQPTDLF
FMIAAPQGANDTHLAALAELSQYLLKDGFADKLRAAATPEAVIAVFDEAS
TAKEEVVAPTSGQDFIVAVTACPTGIAHTYMAEEALKKQAAEMGVAIKVE
TNGASGVANRLTAEDIQRAKGVIVAADKAVEMDRFDGKQFIARPVADGIK
KSQELISLILNNEGNTYHAKNGKSETAVSTEKTSLGGAFYKHLMGGVSQM
LPFVIGGGIMIALAFLLDNMLGVPNDQLGSLGSYHEIAAIFMNIGGAAFS
FMLPVLAGYIAYSIAEKPGLVAGFVAGAIASNGLAFGKVPFAAGGEVSLG
LTGVPSGFLGALVGGFLAGGVILALRKLLAGLPRSLEGVKSILLYPLLGV
LVTGFLMLFVNIPMAAINTALNDFLQGLSGSSAVLMGLLVGGMMAVDMGG
PVNKAAYVFGTGTLAATVANGGSVVMAAVMAGGMVPPLAVFVATLLFKDK
FTKEERESGLTNIVMGLSFITEGAIPFGAADPARAIPSFIAGSALTGALV
GLAGIKLMAPHGGIFVIALTSNPILYLVFVVIGALVSGILFGALRKKA
>M28_Spy1057 glnH, transporter
MTHKIKVLLLAIMSIFLTCNIASAETIAIVSDTAYAPFEFKDSDQIYKGI
DVDIINEVAKRQSWDFSMSFPGFDAAVNAVQSGQASALMAGTTITNARKK
VFHFSEPYYDTKIVIATRKANAIKKYSDLKGKTVGVKNGTAAQAFLNNYK
KKYDYTVKTFDTGDLMYNSLSAGSIAAVMDDEAVIQYAISQNQDIAINMK
GEPIGSFGFAVKKGSGYDYLVNDFNTALKAMKADGTYQAIMTKWLGTDDK
ATTSQATGNPSAKATPIKDSYKIVSDSSFAPFEFQNGKGKYVGIDIELIK
AIAKQQGFKIEIANPGFDAALNAVQSSQADGVIAGATITDARKAIFDFSD
PYYTSNIILAVKAGKNIKNYEDLDRKTVGAKNGTSSYSWLKENAPKYGYN
VKAFDDGSSMYDSLNSGSVDAIMDDEAVLKYAISQGRRFETPLEGISTGE
VGFAVKKGTNPELIEMFNNGLAALKKSGQYDDIIDKYLDSKKAATPSEKG
ADESTISGLLSNNYKQLLAGLGTTLSLTLISFAIAIIIGIIFGMMAVSPT
KSLRLISTVFVDIVRGIPLMIVAAFIFWGVPNLIESMTGHQSPINDFLAA
TIALSLNGGAYIAEIVRGGIEAVPAGQMEASRSLGLSYGTTMRKVILPQA
VKLMLPNFINQFVISLKDTTIVSAIGLVELFQTGKIIIARNYQSFRMYAI
LAIIYLIMITLLTRLAKRLEKRLN
>M28_Spy0736 hylA, hyaluronate lyase precursor
MVYFYLVNQFTFIISFLYRRNLSVNTYFCTHHKQLLLYSNLFLSFAMMGQ
GTAIYADTLTSNSEPNNTYFQTQMLTTTDSEKKVVQPQQKDYYTELLDQW
NSIIAGNDAYDKTNPDMVTFHNKAEKDAQNIIKSYQGPDHENRTYLWEHA
KDYSASANITKTYRNIEKIAKQITNPESCYYQDSKAIAIVKDGMAFMYEH
AYNLDRENHQTTGKENKENWWVYEIGTPRAINNTLSLMYPYFTQEEILKY
TAPIEKFVPDPTRFRVRAANFSPFEANSGNLIDMGRVKLISGILRKDDLE
ISDTIKAIEKVFTLVDEGNGFYQDGSLIDHVVTNAQSPLYKKGIAYTGAY
GNVLIDGLSQLIPIIQKTKSSIEADKMATIYHWINHSFFPIIVRGEMMDM
TRGRSISRFNAQSHVAGIEALRAILRIADMSEEPHRLALKTRIKTLVTQG
NAFYNVYDNLKTYHDIKLMKELLSDTSVPVQKLDSYVASFNSMDKLALYN
NKHDFAFGLSMFSNRTQNYEAMNNENLHGWFTSDGMFYLYNNDLGHYSEN
YWATVNPYRLPGTTETEQKPLEGTPENIKTNYQQVGMTSLSDDAFVASKK
LNNTSALAAMTFTNWNKSLTLNKGWFILGNKIIFVGSNIKNQSSHKAYTT
IEQRKENQKHPYHAYVNNQPVDLNNQLVDFTNTKSIFLESDDSAQNIGYY
FFKPTTLSISKALQTGKWQNIKADDKSPEAIKEVSNTFITIMQNHTQDGD
RYAYMMLPNMTRQEFETYISKLDIDLLENNDKLAAVYDHDSQQMHVIHYE
KKATMFSNHNLSHQGFYSFPHPVKQNQQ
>M28_Spy1708 ihk, two component system histidine kinase
MRLIKKTFLVINGLIIVVVTSILLVLYFAMPIYYTKVKDKEVKREFDQTS
KQIKGKTVTEIRDILTKKINKDNIWYSLVDSDNQLLYPSLQLLDGVSESK
DSQNVNIVTTFDNSYSNVKVMSQKVTLRDGKKMTLLGQSSLQPVTDASKV
LLDLYPSLLMFSVTVGSIVAYLYSRTSSRRILSMSQTAKKMVNLEPNLTC
TIHGKDEIAMLASDINRLYASLSTSIKSLQKEYEKASDSEREKSEFLRMT
SHELKTPITSVIGMIDGMLYNVGDFADRDKYLRKCRDVLEGQAQLVQSIL
SLSKIETLASQNQELFSLKSSLEEEMEVFLVLSELKHLKVTINLEEQFVK
ANKVYLLKAIKNIIDNAFHYTKSGGQVMIQLKDNQLVIKNEAETLLTQQQ
MKQLFQPFYRPDYSRNRKDGGTGLGLFITHQILDQHHLAYRFVVLDQRWM
VFTIDFPSHHDD
>M28_Spy1709 irr, two-component response regulator
MFKILVVEDDDTISQVICEFLKANNYDPDCVFDGQAALDKWQTTSYDLII
LDIMLPSLSGLEVLKTIRKTSDVPIIMLTALDDEYTQLVSFNHLISDYVT
KPFSPLILIKRIENVLRVSTPDEKRQIGDLLVDETEHSVYWQGTLVKLTK
KEYDIIDYLAKRHQKIVTRDQLMDDIWGYSELDTRVLDNHIKNLRKKMTG
IPLKTITGMGYLLGERE
>M28_Spy1671 lrp, leucine rich protein
MCYNGLKTIMKGMAMELKDYFPEMQVGPHPLGDKEWVSVKEGDQYVHFPK
SCLSEKERLLLEVGLGQCEVLQPLGSPWQRYLLDHQGNPPQLFETSQFIY
LNHQQALPDDLVELLQQMIAGLEVILPISATQTAFLCRQAISIKVLRWLE
DLLPTLESDFGLALTMFVGNAWYQVAAGTLRECFEEECQLLTAYLRQQSG
RKLLTFSGLMLWSLLSHHTFLALTRQFHQSLSPQSDMADVVHALWSEHGN
LVQTAQRLYIHRNSLQYKLDKFAQQSGLHLKQLDDLAFAHLFLLKY
>M28_Spy1390 luxS, autoinducer-2 production protein
MICFLSLFSSTSSHFLTICVMIKCKTKEIEMTKEVIVESFELDHTIVKAP
YVRLISEEFGPKGDRITNFDVRLVQPNQNSIETAGLHTIEHLLAKLIRQR
IDGMIDCSPFGCRTGFHLIMWGKHSSTDIAKVIKSSLEEIATGITWEDVP
GTTLESCGNYKDHSLFAAKEWAQLIIDQGISDDPFSRHVI
>M28_Spy0234 mecA, negative regulator of genetic competence
MRMEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDEL
DLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEINKDINLEDLAEFGDMSQM
TPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPS
TNHESEPLDYVHYVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTI
LLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLMLDGAVEQLQ
KIELG
>M28_Spy0372 phoH, PhoH
MQEYSIDITLTHPDDVLALFGSNERHLKLIEAHLGVIVHARTERVQVIGD
DEEAVELARLTIKALLVLVGRGMVVNTSDVVTALSMAESHQIDQFMALYE
EEIIKDNYGKAIRVKTLGQKTYVDSVKRHDVVFGVGPAGTGKTFLAVTLA
VTALKRGQVKRIILTRPAVEAGESLGFLPGDLKEKVDPYLRPVYDALYHI
LGKEQTTRLMERDVIEIAPLAYMRGRTLDDAFVILDEAQNTTIMQMKMFL
TRLGFNSKMIVNGDTSQIDLPRNVKSGLIDATQKLQGIKQIDFVYFSAKD
VVRHPVVADIIKAYETSSEEMKDLLKPKASDVEADYQPGLTKYPVIGQEH
>M28_Spy1377 pppL, protein phosphatase 2C
MKISLKTDIGQKRSNNQDFINKFDNKKGITLVILADGMGGHRAGNIASEM
TVTDLGREWVKTDFTELSQIRDWLFETIQSENQRIYDLGQSEDFKGMGTT
VEAVALVESSAIYAHIGDSRIGLVHDGHYTLLTSDHSLVNELVKAGQITE
EEAASHPQRNIITQSIGQASPVEPDLGVRVLEPGDYLVINSDGLTNMISN
DEIVTILGSKVSLDEKNQEMIDLANLRGGLDNITIALVHNESEDVE
>M28_Spy0465 ptsK, hpr(ser) kinase
MVSLFSFSSEKMSICKGLTVDLCYNIEKGEIMTVTVKMLVQKVKLDVVYA
TDNLLSKEITTSDISRPGLEMTGYFDYYAPERLQLFGMKEWSYLTQMTSH
NRYSVLKEMFKKDTPAVVVSRNLAIPKEMVQAAKEEGISLLSSRVSTSRL
AGEMSYFLDASLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKR
GHRLVADDRVDVYAKDEETLWGEPAEILRHLLEIRGVGIIDVMSLYGASA
VKDSSQVQLAIYLENFEAGKVFDRLGNGNEEITFSGVRIPRIRIPVKTGR
NVSVVIEAAAMNHRAKEMGFDATKTFEDRLTQLITKNEVSQ
>M28_Spy1674 relA, GTP pyrophosphokinase
MRNEMAKIMNVTGEEVIALAATYMTKTDVAFVAKALAYATAAHFYQVRKS
GEPYIVHPIQVAGILADLHLDAVTVACGFLHDVVEDTDITLDEIEADFGQ
DARDIVDGVTKLGKVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRL
HNMRTLKHLRKDKQERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLN
ETEFYKISHMMKEKRREREALVEAIVSKVKTYTTQQGLFGDVYGRPKHIY
SIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRF
KDYIAAPKANGYQSIHTTVYGPKGPIEIQIRTKDMHQVAEYGVAAHWAYK
KGVRGKVNQAEQAVGMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIY
VFTPTGAVQELPKESGPIDFAYAIHTQIGEKATGAKVNGRMVPLTAKLKT
GDVVEIITNANSFGPSRDWVKLVKTNKARNKIRQFFKNQDKELSVNKGRD
LLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFGDISPIS
VFNKLTEKERREEERAKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQ
GASGLLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHNIKSQDGYQER
LIEVEWDLDNSSKDYQAEIDIYGLNRSGLLNDVLQILSNSTKSISTVNAQ
PTKDMKFANIHVSFGIPNLMHLTTVVEKIKAVPDVYSVKRTNG
>M28_Spy1359 rocA, sensory transduction protein kinase
MLEDFLQFLGFIFLDIIEIMLTLKLFSFVSAIPLRLKNIFYLSLSMVLFQ
VVFWAFFPDHFILDVVMLAQFLFFALIALYYGKSIKAKFLMFYAFFPLVS
ISLVKRFIVFFVMPLFGMPYSVVKHNTLLIYSITCFSIFLIYRCIQVFHF
DFSTWRQYFQSHRASKLLVFTNSSMALYYLCVQGIDVMSPSLSGLATTTA
RSIIVLFYFILFLTLLIHLERYVKQNSIEAIVQQKEYRELINYSQHLGLL
YQDIQELRQLLTTVSSRLKIGIEQNDISIVRLTYEGILNAEKNNAKDDRL
DLTCLDKLQVEAIRHIVLAKLIEAKNKKLKVEVSIPNCIATFFLEVVDFT
KLLSFLLDNAIEMSLETKQPCLSIAFLDQNHKLVIVIQSSTKQGQNDSQS
VFATPALKKRDDWQFDLRNVTTILNRYDYLTISSQIHDGILTQLIEIAKP
D
>M28_Spy1615 salR, transcriptional regulatory protein
MKILLIDDHRLFAKSIQLLFQQYDEVDVIDTITSHFNDVTIDLSKYDITL
LDINLTNISKENGLEIAKELIQSTPHLKVVMLTGYVKSIYRERAKKVGAY
GFVDKNIDPKQLISILKKVDSGKKYFEQIESQDYVESLTDQEIAILNLSK
KGFSIKEIEETLQISRRTVFNHLTHIYSKLLVNNKQEAIYKAEQLGYFMD
F
>M28_Spy0337 spyA, C3 family ADP-ribosyltransferase
MSGGTMLKKRYQLAMILLLSCFSLVWQTEGLVELFVCEHYERAVCEGTPA
YFTFSDQKGAETLIKKRWGKGLVYPRAEQEAMAAYTCQQAAPINTSLDKT
KGELSQLTPELRDQVAQLDAATHRLVIPWNIVVYRYVYETFLRDIGVSHA
DLTSYYRNHQFDPHILCKIKLGTRYTKHSFMSTTALKNGAMTHRPVEVRI
CVKKGAKAAFVEPYSAVPSEVELLFPRGCQLEVVGAYVSQDQKKLHIEAY
FKGSL
>M28_Spy0780 srtK, sensor protein
MVINGMFKKYSIKNRVWRAVVEIVFGVCITVLMIAIISLSFSKLNIVTSH
NVGEEFYIKDKQSIKQLNNYMKTLGLDYVVFDRKTDKAMEGKYLSKEFSL
FNEVAEEKNNLTFNSVHYDLYTNINYNIVIRYNEIPEFSNHYLRNVSYNM
LTFYILGIGTSISIVVALTRFVKEISLNFKEIKKLANKMGIEVLSENENY
SKIIEFDDILRTLHIKGDNLKSLIEREILEKQDLSFQIAALSHDIKTPLT
VLKGNLELLELTTLNKNQEGYIVSMNNSISVFEGYFNSLISYTRMLSEDR
SVKLILVEKLLSELHFEVDDLLNINNIEFSICNRLIITSFYGDEENLIRA
LSNLLVNAIRFMPVLDKKIEVILSESGEQIHFEIWNNGERFSDSTLKKGD
KLFYTEDYSRGNKHYGIGLAFVKGVAIKHGGNLQLNNPARGGASAIISIK
KKI
>M28_Spy0779 srtR, two-component response regulator
MYKILAIDDDKEILKLMKTALEIENYHVITCQEIELPIVFDDFKGYDLIL
LDIMMPNISGTEFCYKIREEVHSPIIFVSALDGDNEIVQALNIGGDDFIV
KPFSLKQFVAKVNSHLKREERAKIKNEAEERVKRSFPPIEIYLEERMLYI
DKQPLFLTYREYEILELLSRHPYKVFTKEEIYEQVYSDEASALFHSISEY
IYQIRMKFSSFGINPIKTIRGIGYKWDV
>M28_Spy1564 srv, transcription regulator, crp family
MLISLEDTNYTLVKEYLEKSVNHHILQRYIDNHNFPIIEKSYHKYLTFES
LEEDFTYILKDGIVKQSVLSKYGMEFNLRYVTGLEITSVLNTGYSKDMGE
PYNVRIESEKASFYKVRRSAFLKDINEDIELQGYVKDFYHNRLQKSMKKM
QCMLTNGRIGAISTQIYDLMTLFGEELPNGQILINFVITNEELGKFCGIS
TASSVSRILKQLKEKNIIRIDKQHIIITNLDKLKDNIVF
>M28_Spy1194 typA, GTP-binding protein TypA/BipA
MTNLRNDIRNVAIIAHVDHGKTTLVDELLKQSHTLDERKELQERAMDSND
LEKERGITILAKNTAVAYNDVRINIMDTPGHADFGGEVERIMKMVDGVVL
VVDAYEGTMPQTRFVLKKALEQNLIPIVVVNKIDKPSARPAEVVDEVLEL
FIELGADDEQLEFPVVYASAINGTSSLSDDPADQEHTMAPIFDTIIDHIP
APVDNSDEPLQFQVSLLDYNDFVGRIGIGRVFRGTVKVGDQVTLSKLDGT
TKNFRVTKLFGFFGLERREIQEAKAGDLIAVSGMEDIFVGETITPTDCVE
ALPILRIDEPTLQMTFLVNNSPFAGREGKWITSRKVEERLLAELQTDVSL
RVDPTDSPDKWTVSGRGELHLSILIETMRREGYELQVSRPEVIIKEIDGV
KCEPFERVQIDTPEEYQGAIIQSLSERKGDMLDMQMVGNGQTRLIFLIPA
RGLIGYSTEFLSMTRGYGIMNHTFDQYLPVVQGEIGGRHRGALVSIENGK
ATTYSIMRIEERGTIFVNPGTEVYEGMIVGENSRDNDLGVNITTAKQMTN
VRSATKDQTAVIKTPRILTLEESLEFLNDDEYMEVTPESIRLRKQILNKA
ARDKANKKKKSAE
>M28_Spy0424 vicK, two-component sensor histidine kinase
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRD
LINGRYTDIIDEKADIELMELSDQLNDLSDVFRLTHENLAQEKNRLASIL
AYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYT
YRDLVSKTPVVTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTT
EQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALKEDIAPSFIKV
SLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVK
NQHTGTGKVYEIVRDYPITSVWIEIDNDKMTQVIENILNNAIKYSPDGGK
ITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD
>M28_Spy0423 vicR, two-component response regulator
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLII
LDLMLPELDGLEVAKEIRKTSHVPIIMLSAKDSEFDKVIGLEIGADDYVT
KPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAF
VAKKHGQEVELTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRT
VDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD
>M28_Spy1373 yvqC, two-component response regulator
MTMSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALAL
KPDVLVMDLVMPELGGVEATLEVLKKWKEAKVLVLTSYLDNEKIYPVIDA
GAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEEL
TAREYDILHLLAKGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQA
VVYAFRHHLVPQDDN
>M28_Spy1374 yvqE, two-component sensor protein
MKKRYYALVWLYSTITILSIVFVVMDNLGITFNYLRNHLWQVERLGFSIL
LLIVSVTLLLLLLWIIMDDNSKRNINQNLKYILNNRRLYLDETSEINTNL
SRLSKKMSHLTANMQKKESAYILDSQEVVKQERKRIARDLHDTVSQELFA
SSLILSGISMSLEQLDKTQLQTQLTTVEAMLQNAQNDLRILLLHLRPTEL
ANRTLSEGLHMILKELTDKSDIEVIYKETIAQLPKTMEDNLFRIAQEFIS
NTLKHAKASRIEVYLNQTSTELQLKMIDDGVGFDMDQVRDLSYGLKNIED
RVNDLAGNLHLISQKGKGVSMDIRLPIVKGDDDE