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# Streptococcus pyogenes M1 GAS, SF370

>SPy0874 putative two-component response regulator
MKILLAEDEWQMSNVLTTAMTHQGYDVDVVFNGQEAIDKAKDNAYDIMIL
DIMMPIKSGIEALKEIRASGNCSHIIMLTAMAEINDRVTGLDAGADDYLT
KPFSLKELLARLRSMERRVESFTPQVLQFAGVTLNINEQELSAGNAIRLA
SKEGKLMAFLMLNQGKYLDTKTLYQHVWSDQEDYDTSIVWVYISYLRQKL
LAIQANVIIAGDKDTSYCLLEK
>SPy0244 putative histidine kinase
MMVIYSMALFYATIFINSWVIFAKVSAIKLSWKRVSIIGISFVIANMIFD
KVILIDQLFFIIVSLLSAPKKKLFEHMFNGFFTILIVELLFRVIGSFFLP
AVLGFSIGQINNNLKLLELCYLFVLPIFYLFSYIFSIDLSLIRFISEDKM
KKWVFWMNTAMFSYYFFAHFLVTVQSGFLALYFQYRSILVFIYLAIFIWV
IVKLDRFAKDQLSQKLTQAQNERIAYLENYNQSIEQLYREIRTVKHDSEN
ILISLKDSIDSGDIDLITRVYDTVIQQSATSMMRTNYEISSLDNIKEAVI
RSIMNSKLLEAQYLGIELYIEIPDVIDHLPIKLIDLIVLFTGLVDNAIET
AKGSRRPFLSIAYFKQDNKQLFIIENSTKTNRVDIAKRFDAQQQNSAHFL
TVLDSYPQITLSTKSDHYRLRQLLEMR
>SPy1274 putative amino acid ABC transporter, periplasmic amino acid-binding protein
MIIKKRTVAILAIASSFFLVACQATKSLKSGDAWGVYQKQKSITVGFDNT
FVPMGYKDESGRCKGFDIDLAKEVFHQYGLKVNFQAINWDMKEAELNNGK
IDVIWNGYSITKERQDKVAFTDSYMRNEQIIVVKKRSDIKTISDMKHKVL
GAQSASSGYDSLLRTPKLLKDFIKNKDANQYETFTQAFIDLKSDRIDGIL
IDKVYANYYLAKEGQLENYRMIPTTFENEAFSVGLRKEDKTLQAKINRAF
RVLYQNGKFQAISEKWFGDDVATANIKS
>SPy1236 putative histidine kinase protein
MNKLKKEILSDNYNHFFHFFAVFTGIFVIMTIIILQIMRFGVYSSVDSSL
VSVSNNASSYANRTMARISSFYFDTENNIIKALPDSDSSKLLGTPAANTD
IILFSANGTILNAFDAFSNYQNFHLDKRRLGSIETTSLMNFYGQEEKYHT
ITVGVHIKNYPAVAYMMAVVNVEQLDRANERYERIIIIVMSVFWLISILA
SIYLAKWSRKPILESYEKQKMFVENASHELRTPLAVLQNRLESLFRKPNE
TILENSEHLASSLDEVRNMRILTTNLLNLARRDDGINPQWTHLDTDFFNA
IFENYELVAKEYGKIFYFQNQVNRSLRMDKALLKQLITILFDNAIKYTDK
NGIIEIIVKTTDKNLLISVIDNGPGITDEEKKKIFDRFYRVDKARTRQTG
GFGLGLALAQQIVMSLKGNITVKDNDPKGSIFEVKL
>SPy1780 conserved hypothetical protein
MKKRIKAILVKLLKEDSSMSLKYKRILVAIDGSYESELAFNKGVNVALRN
DATLLLVHVIDTRALQSVATFDTYIYEKLEQEAKDVLDDFEKQAQIAGIT
NIKQIIEFGNPKNLLAHDIPDRENADLIMVGATGLNTFERLLIGSSSEYI
MRHAKIDLLVVRDSTKTL
>SPy0176 conserved hypothetical protein
MNLKQAFIDNNSIRLGLSADTWQEAVRLAVQPLIDSKAVTSAYYDAIIAS
TEKYGPYYVLMPGMAMPHAEAGLGVNRNAFALITLTKPVTFSDGKEVSVL
LTLAATDPSIHTTVAIPQIVALFELDNAIERLVACQSPKEVLEMVEESKD
SPYLEGMDLNA
>SPy1106 putative two-component response regulator
MNVLIIEDDPMVDFIHRNYLEKLNLFDRIISSDSMKAVQSILTDYAIDLI
LLDIHITDGNGIQFLEKWRTQHIPCEVIIISAANDGNIIRDGFHLGIIDY
LIKPFTFERFQESIQQFVTHREHLANQQLEQAQIDQLKCLTSKKDTKNKQ
LLEKGLSESTFQWIMENIKVFDQPFTIQELASACHLSHVSVRKYIAYLEE
NKQLNSQQIFTKVGRPYRVYW
>SPy1002 hypothetical protein-phage associated
MIDFVQIGAFCGAALSILGVWGFIVNPFKKAMEANEFAMAQLKDSIKELA
YELKNLDREREITKKIIDRHEERLGRVEDEVIINKERIITLFKKGEEK
>SPy2027 putative two-component response regulator
MFKILVVEDDDTISQVICEFLKANNYDPDCVFDGQAALDKWQTTSYDLII
LDIMLPSLSGLEVLKTIRKTSDVPIIMLTALDDEYTQLVSFNHLISDYVT
KPFSPLILIKRIENVLRVSTPDEKRQIGDLLVDETEHSVYWQGTLVKLTK
KEYDIIDYLAKRHQKIVTRDQLMDDIWGYSELDTRVLDNHIKNLRKKMTG
IPLKTITGMGYLLGERE
>SPy1857 putative transcriptional regulatory protein
MLISLEDTNYTLVKEYLEKSVNHHILQRYIDNHNFPIIEKSYHKYLTFES
LEEDFTYILKDGIVKQSVLSKYGMEFNLRYVTGLEITSVLNTGYSKDMGE
PYNVRIESEKASFYKVRRSAFLKDINEDIELQGYVKDFYHNRLQKSMKKM
QCMLTNGRIGAISTQIYDLMTLFGEELPNGQILINFVITNEELGKFCGIS
TASSVSRILKQLKEKNIIRIDKQHIIITNLDKLKDNIVF
>SPy0706 hypothetical protein, phage associated
MATELIFGVGGFILAIVTTYNIFNAKSIKHATDITLLQSEVEHLKIVTRQ
NARRLEEHAEQNKTLITMTEQIKNLTDDVKDLKDMMRGEIK
>SPy1587 putative two-component sensor response regulator
MYKVLLVDDEYMILQGLTMIIDWQALGFEVVQTARSGKEALAYLTQYPVD
VMISDVTMPGMTGLDLIEAAKTYHPQLQTLILSGYQEFSYVQKAMELETK
GYLLKPVDKAELQAKMKQFKDWLDAQQAESIRQEAYHDSLLTLWLTDELS
EKEFQQLSQGLPAAALTGFTVLYLDCQEWQAAIDAYFEREGQPFYLKKEE
DKKVYLAVLLGKTDQAKAFTYDLQKRFSRNMHQLILGETVDDWENVYESY
NQVLKSLFYNCEVSPIRAKDKSKIELPESRLQFFAFNKALMIGDEPTILS
KLEAIFDEMKTLNFSPEDVKHVSFLLFSDIYRQFPILDKMTYLSMVKTIH
DSQSIDCILRELKKVLDVTNQNNSPEKRYSDLVSETIDCIRKEYHQELTL
KAIADRLHVNGVYLGQCFKNETERSFTQYLNHVRIQKAQQLLLYTNQSIN
EIAYETGYNTNHYFIKMFKKLNGLSPKEFRDRYKDNYQAIKGDQ
>SPy0245 putative response regulator
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQE
RGDHQLYFLDIEIGEYTRCGLELAAAIRQKDPNAVIVFVTTHSEFAPISF
KYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQT
RLKLPYKDILYFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCH
RSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFERWEALR
>SPy1441 hypothetical protein
MATELIFGVGGFILAIVTTYNIFNAKSIKHATDITLLQSEVEHLKIVTRQ
NARRLEEHAEQNKTLITMTEQIKNLTDDVKDLKDMMRGEIK
>SPy1622 putative two-component sensor histidine kinase
MKKRYYALVWLYSTITILSIVFVVMDNLGITFNYLRNHLWQVERLGFSIL
LLIVSVTLLLLLLWIIMDDNSKRNINQNLKYILNNRRLYLDETSEINTNL
SRLSKKMSHLTANMQKKESAYILDSQEVVKQERKRIARDLHDTVSQELFA
SSLILSGISMSLEQLDKTQLQTQLTTVEAMLQNAQNDLRILLLHLRPTEL
ANRTLSEGLHMILKELTDKSDIEVIYKETIAQLPKTMEDNLFRIAQEFIS
NTLKHAKASRIEVYLNQTSTELQLKMIDDGVGFDMDQVRDLSYGLKNIED
RVNDLAGNLHLISQKGKGVSMDIRLPIVKGDDDE
>SPy1711 putative PTS system, enzyme IIA component
MFPNILFTEARTQPELFDLVASHLEKVGYVTQEYHQALVEREAVFPTGLK
VDLKDGSDILYAAIPHTETKYCLVDQVVYVRNSQALTFKHMINPEEDCLV
TDFFFIINSQNEGQTTILSNLITFFITKGNLSYLASLKDDKQAISNYLIE
KGVFQHD
>SPy1146 hypothetical protein
MLDSYIKRIVIHQFSPNDTELLLSDRLVSITPRIDEYFRKKLAKVFSDEA
KRGQFEANNTFFTTIGDDLLETSVTIAQLWKEAFVISEDQKTNDLVFVQF
DKDGEPFFAFLRIALKEQFAHLSDNYEHPFTVTQNNLPSPTQTPDEALVI
NLKSGQYYLIEKRVKHNGSFANYFSEHLLKVTPEQSVKKSIKMIEQTAQK
IAEHFNQDDFTFQSKMKSTLFKQLEADDVLSPEKLADQLFDDNLTARLTF
VDQVKDVIPEPIKISDIEHSRQIKKLENQKLSLSNGIELTVPNAIYQDAE
AVEFLLNDDGTYSILIKNIEDIKTK
>SPy0539 hypothetical gene
MSMMDKTVLYFGLVEISFDVPDFIFQKIKEQNNKIRYYSKSINILGSVKF
INSNQQFIEYDGNGNILVYGRLKYFKEGISLYYIGEYLAECLLIEHSDTL
LIHAAAVYNPLSGHSILLLGDKGAGKTTVAIRLCIEHGYHLIGNDQVIFG
SNSGILLTYAGTSFFKIRRTAVLSDNLLFKLFSKFFNRSLQFNKASWDDK
ISIFPKELGIRTCNFSTEISKIYYIKTDKKEKQIYHSIWSDSLASLYLNE
LLGRHISGQVACFQSDNGKYFSTMPLINYEKNNRVREQIVKGIFAKQKLF
KITAATPAKIAEAIIENVKKNS
>SPy0903 putative ABC transporter (binding protein)
MLYYSYLNKGVTMKKSVTLLSIGLASLLLAACAPHQSQKSSWDTIKEKGV
LKVATPGTYQPTSFYNDNNELVGYEVDMVKEIGKRLNIKVKFVETGFDQA
FTSVDSGRVDISLNNFDITPKRQKKYNISTPYKYGVGGMIVRADGSSNIA
KKDLSDWKGKKAAGASGTEYMKVAQKQGAELVTYDNVTGDVYLNDVANGR
TDFIPNDYPAQKLFVDYMLSQNPNLNVKMSDVQYNPTEQGIVMNKKDDSL
KKKIDAVIKDMIKDGSLKKISETYYAGQDLTKPFGKDKKIPVIDTKDVN
>SPy1571 hypothetical protein
MAKQKNRKKALKLEMKRNGLLKKAGQVFDKAVESVETAVDKTISAGKNLV
EKGSQTVENLTASKERLTLDEFAGQPVVAGIRSDLVETLYAEGIHSAQAF
KEWTEKDLLALKGIGPATVKKLVENGASFKK
>SPy1527 putative GTP-binding protein TypA/BipA (tyrosine phosphorylated protein A)
MTNLRNDIRNVAIIAHVDHGKTTLVDELLKQSHTLDERKELQERAMDSND
LEKERGITILAKNTAVAYNDVRINIMDTPGHADFGGEVERIMKMVDGVVL
VVDAYEGTMPQTRFVLKKALEQNLIPIVVVNKIDKPSARPAEVVDEVLEL
FIELGADDEQLEFPVVYASAINGTSSLSDDPADQEHTMAPIFDTIIDHIP
APVDNSDEPLQFQVSLLDYNDFVGRIGIGRVFRGTVKVGDQVTLSKLDGT
TKNFRVTKLFGFFGLERREIQEAKAGDLIAVSGMEDIFVGETITPTDCVE
ALPILRIDEPTLQMTFLVNNSPFAGREGKWITSRKVEERLLAELQTDVSL
RVDPTDSPDKWTVSGRGELHLSILIETMRREGYELQVSRPEVIIKEIDGV
KCEPFERVQIDTPEEYQGAIIQSLSERKGDMLDMQMVGNGQTRLIFLIPA
RGLIGYSTEFLSMTRGYGIMNHTFDQYLPVVQGEIGGRHRGALVSIENGK
ATTYSIMRIEERGTIFVNPGTEVYEGMIVGENSRDNDLGVNITTAKQMTN
VRSATKDQTAVIKTPRILTLEESLEFLNDDEYMEVTPESIRLRKQILNKA
ARDKANKKKKSAE
>SPy0039 putative protein-tyrosine phosphatase
MKKVCFVCLGNICRSPMAEFVMKSIVSSDVMMIESRATSDWEHGNPIHSG
TQSILKTYQINYDITKCSKQITITDFNTFDYIIGMDSDNVKNLKEMSQHQ
WDSKIYLFREGGVPDPWYTNDFEETYQLVRKGCQDWLSRLMSKEY
>SPy1536 conserved hypothetical protein
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGK
EDKRKGAYQFVAVGISRASLAQLLYAWLTPFTEISTAEDTTGGYSDADFL
RINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHL
ADTVTGVNGKQFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIK
LKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMFTLDIYDQITK
EDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVD
KEIKKVNPNAISNYEEAKRAAKRLKTKMKIVPVTTVQEALVYLRK
>SPy1315 hypothetical protein
MTHKIKVLLLAIMSIFLTCNIASAETIAIVSDTAYAPFEFKDSDQIYKGI
DVDIINEVAKRQSWDFSMSFPGFDAAVNAVQSGQASALMAGTTITNARKK
VFHFSEPYYDTKIVIATRKANAIKKYSDLKGKTVGVKNGTAAQAFLNNYK
KKYDYTVKTFDTGDLMYNSLSAGSIAAVMDDEAVIQYAISQNQDIAINMK
GEPIGSFGFAVKKGSGYDYLVNDFNTALKAMKADGTYQAIMTKWLGTDDK
ATTSQATGNPSAKATPTKDSYKIVSDSSFAPFEFQNGKGKYVGIDIELIK
AIAKQQGFKIEIANPGFDAALNAVQSSQADGVIAGATITDARKAIFDFSD
PYYTSNIILAVKAGKNIKNYEDLDRKTVGAKNGTSSYSWLKENAPKYGYN
VKAFDDGSSMYDSLNSGSVDAIMDDEAVLKYAISQGRRFETPLEGISTGE
VGFAVKKGTNPELIEMFNNGLAALKKSGQYDDIIDKYLDSKKAATPSEKG
ADESTISGLLSNNYKQLLAGLGTTLSLTLISFAIAIIIGIIFGMMAVSPT
KSLRLISTVFVDVVRGIPLMIVAAFIFWGVPNLIESMTGHQSPINDFLAA
TIALSLNGGAYIAEIVRGGIEAVPAGQMEASRSLGLSYGTTMRKVILPQA
VKLMLPNFINQFVISLKDTTIVSAIGLVELFQTGKIIIARNYQSFRMYAI
LAIIYLIMIILLTRLAKRLEKRLN
>SPy0317 conserved hypothetical protein
MIKKQYLGRATIALASTLVLAACGSSKTAESGNQGSSKEVLFATVGTTAP
FSYEKGGQLTGYDIEVAKAVFKGSDDYKVSFKKTEWSSIFTGLDSGKYQM
GGNNISFTKERSAKYLFSYPIGSTPSVLVVPKDSDIKSFDDIQGHTTQVV
QGTTSVAQLEDFNKKHSDNPVTLKFTNENITQMLTNLSEGKADFKIFDAP
TVNAIIKNQGLDNLKTIELTSTEQPFIYFIFSQDQEKLQSFVNKRIKELT
ADGTLSKLAKEHLGGDYVPSDKELKLPTAN
>SPy0277 putative glutamine-binding periplasmic protein
MKKLILSCLVALALLFGGMSRAQANQYLRVGMEAAYAPFNWTQDDASNGA
VPIEGTSQYANGYDVQVAKKVAKAMNKELLVVKTSWTGLIPALTSGKIDM
IAAGMSPTKERRNEISFSNSSYTSQPVLVVTANGKYADATSLKDFSGAKV
TAQQGVWHVNLLTQLKGAKLQTPMGDFSQMRQALTSGVIDAYISERPEAM
TAEAADSRLKMITLKKGFAVAESDAAIAVGMKKNDDRMATVNQVLEGFSQ
TDRMALMDDMVTKQPVEKKAEDAKASFLGQMWAIFKGNWKQFLRGTGMTL
LISMVGTITGLFIGLLIGIFRTAPKAKHKVAALGQKLFGWLLTIYIEIFR
GTPMIVQSMVIYYGTAQAFGISIDRTLAAIFIVSINTGAYMSEIVRGGIF
AVDKGQFKAATALGFTHGQTMRKIVLPQVVRNILPATGNEFVINIKDTSV
LNVISVVELYFSGNTVATQTYQYFQTFTIIAIIYFVLTFTVTRILRYIER
RFDADTYTTGANQMQIAEVSNV
>SPy0685 hypothetical protein, phage associated
MNKRIKKKRKLETAVVMLVAENAMQVEAIKNQNKQIMELKSIVQRNALAT
NEELATVKAATLDNQSVIKAIGDTVDYIKKNYKRKWGK
>SPy1621 putative two-component response regulator
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKP
DVLVMDLVMPELGGVEATLEVLKKWKEAKVLVLTSYLDNEKIYPVIDAGA
KGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTA
REYDILHLLAKGYDNQTIADELFISLKTVKTHVSNILAKLEVGDRTQAVV
YAFRHHLVPQDDN
>SPy0975 conserved hypothetical protein-phage associated
MTTRKSKYWRDRIKKEMDAKEADDISLEQSMKQLHDYHFRNIEKEIESFY
QRYADKEKIDLSEARKRASELDISAYQKKAKELVAKAEKLRREGKIVTRD
DFTHQENADMSIYNLAMKTNALELLRLNIDLEMQELANGEHKLTKKFLDE
GYRKETEFQAGLLGLSVASQASVKSLADAVINANFKGAKWSDNIWDRQDK
LRSIISQSVQSAILKGKNGLTIARDIRREFDVSASYAKRLAITEHARVQM
EVGRLSMAENGFAMFDILPEPKACDVCKDIAKHGPYHLDKWRIGENSPPF
HPYCRCAIVGVDESGVATDRQLDYNRNMNNIDLMAKTQSFIINKDVRVSA
KKVVGTRYDFWAQDNTKKIRDTIQSVGEHLDNLEGYSIPKIVFVKKAKLQ
GWAGYDYKQDTLFISDLLNSKAAVSDMLLDNYFAAVDLNGILVHELTHKK
HWDTAKQFYKHNKKRYNTLEEAKNALDSSLVSYIKEQKQSDYNYLYKISE
YADVASLQGKYNEVIAEAMTAGDKLSDPLLLEKIKEVFRWK
>SPy1588 putative two-component sensor histidine kinase
MSVKTLGRYVTNHFKQGFLINRLMKLYSLLIVSFFTLAAIGLSSYSISST
YKRVDAEAQMRLEETLGRLQSQNDITLRVLDQLVGRSEDYHNLYQYMTLT
PNQYFSNVFEDWEKGKDTVLFSEEVRRLFDLYPDVTSMTLLLEDSSAYLY
ADKVIKTGRLLYSKPEKVTGNVLVRSIRNPESGDVTGRLYLTFDKPPTLV
ETQQDHYLATFAFDYYGRKLFHQGGRRFPHLEAEVKKAIKADRAADLSNL
SKAYRMQYNRSGDLLAYVAVRKSYLLAEAVRTVFVYGLVSLLLAWLLLQL
LFRVFRNYIQQVSEITDTVEMVAAGDLSLTIDNSHMELELYHISEAINQM
LASIKAYIDEVYVLEVEQRDAQMRALQSQINPHFLYNTLEYIRMYALSCQ
QEELADVIYAFASLLRNNISQDKMTTLKEELAFCEKYIYLYQMRYPDSFA
YHVKIDESVADLAIPKFVIQPLVENYFVHGIDYSRHDNALSIKALDETDH
LLIQVLDNGRGISQERLADMEKRLQEHQTTGNSSIGLQNVYLRLFHHFRD
RVSWSMAKEPNGGFIIQIRIRKDA
>SPy0778 putative ABC transporter (substrate-binding protein)
MNFKKIRFGFLLCLLLYPLAACNKSEQLNHYERIKKTRKLVVAVSPDYAP
FEFKALVNGKDTIVGADVQLAQAIADELDVDLELSPMSFDNVLSSLQTGK
ADLAISGISHTKERAKVYDFSIPYYQAENAIVMRASDAKVTKNISDLNGK
KVAAQKGSIEEGLVKIQLPKANLISLTAMGEAINELKAGQVYAVTLEAPV
AAGFLAQHKDLALAPFSLKTSDGDAKAVALPKNSGDLTKAVNKVIAKLDE
QERYKSFIAETIALTKNTMK
>SPy0242 putative histidine kinase, possibly involved in competence
MANSEYMFLLLSIIVYYMTKIYIFSFLSDITLPVWKQLTILALALFFNQF
PYLSPLLIDPLLFLVVLRQETKQLFSLKALFLAVAPSVLVDLLSRFMGTI
VIPYLFLSSGIYLGHIIFDLLAYLLIFPSFAIINYMIGKDYKMICQSGYS
KRSHNFYQTLLMFVLVYYVDIFVILGFTDPFLHFHHSLFVPTPYKLLFLM
FILLLVYLLSYFNHSSKEYLKNELRREQQAYMTNLEIYGKHLEKLYRDVR
AFQSDYLSRIERLGQAIKSESITQIQDIYAQTVHEANDYWDDKHYNISKL
RKINISSIKSLLSAKIISAEKSGIDLNVEVPDNIKETYIPELDLLLLMSI
FCDNAIEAALEAQQPHMSIAYFLLGDYQMFVVTNTTKKKVDINKIFEEGY
SSKGSERGIGLSNAQRILKKYPYLSLRTKSFDKEFSQTLTMPKEEVDR
>SPy0875 putative two-component sensory transduction histidine kinase
MFNRIRIRFIMIASIAIFIILSSIVGIINTARCYQSQQEINRILHLISSN
KGKLPGTTESSKRLGTKLSEDSLSQFRYYSVIFNANGHLLSSNTANISAL
DREEAQYFARLFAKSGEEKGSYRHQDSVYSYLITQLPNEEKLVVILDTTF
YFRSVGDLLAVSVMLAFGGFIFFVVLVSLFSGMVIKPFVQNYEKQRRFIT
NAGHELKTPLAIISANNELVELMTGESEWTKSTSDQVKRLTGLINQMITL
ARLEEQPDVVLHMVDFSAIAQDAAEDFKSLVLKDGKRFDLTIQPNIMIKA
EEKSLFELVTILVDNANKYCDPKGLVKVSLTTIGRRRKRAKLEVSNTYLE
GKSIDYSRFFERFYREDESHNSKEKGYGIGLSMAESMVKLFKGTITVNYK
NDAIVFTVVI
>SPy2026 putative histidine kinase
MRLIKKTFLVINGLIIVVVTSILLVLYFAMPIYYTKVKDKEVKCEFDQTS
KQIKGKTVTEIRDILTKKINKDNIWYSLVDSDNQLLYPSLQLLDGVSESK
DSQNVNIVTTFDNSYSNVKVMSQKVTLRDGKKMTLLGQSSLQPVTDASKV
LLDLYPSLLIFSVTVGSIVAYLYSRTSSRRILSMSQTAKKMVNLEPNLTC
TIHGKDEIAMLASDINRLYASLSTSIKSLQKEYEKASDSEREKSEFLRMT
SHELKTPITSVIGMIDGMLYNVGDFADRDKYLRKCRDVLEGQAQLVQSIL
SLSKIETLASQNQELFSLKSSLEEEMEVFLVLSELKHLKVTINLEEQFVK
ANKVYLLKAIKNIIDNAFHYTKSGGQVMIQLKDNQLVIKNEAETLLTQQQ
MKQLFQPFYRPDYSRNRKDGGTGLGLFITHQILDQHHLAYRFVVLDQRWM
VFTIDFPSHHDD
>SPy1107 putative two-component sensor histidine kinase
MKKPLRLWASLSLILVSMIVVTTSLFYGIMLHDTHQSIKNQETHLLTSTG
KMLASHQAIKELLLNNQPNAKTTAYTNSIASIYNLDYVVVMNMKGIRLTH
PNPKNIGKPFQGGDEEAVLAGKKVISTAKGTLGKSLRYLVPVFDGDKQIG
AIAVGIKLTTLNDVALTSKRNYTLSLLLCLLISLLVTSFISFRLKRQLHQ
LEPSEIYQLFEERNAMLDQIEAAVFVVDKAGILQLCNQAGQKLIARKCQL
GKPTGNSFNYLFPDFPKLSLQEGHEQLFRYGEEDYLLAISPICVKNDHRG
HIIFMREAVKAIDTLDQLAYTTAYASALQAQTHKFMNQLHVIYGLVDIAY
YDQLKIYLDSILEPENEILTSLSVLVKEPLLASFLIGEQEKYQELNVHLK
IDVLSEIPHSATKNQLNNGLMIYRFIHTNLLTTLRPKSLVLSIQHDQNHL
ISHYTLTDNWIDLERVQPIFDLPYFQQLLTDTNSQFHQHQTVTELQFSVT
TPYVGGQHERFNH
>SPy1365 conserved hypothetical protein
MNKSKKIEQYQLMIAQAKELFANESNALANLSNASALLNMTLPNSVFTGF
YLFDGQELILGPFQGRVSCVHIKLGKGVCGESAQSRRTIIINDVKQHANY
ISCDAAAMSEIVVPMVKEGHLIGVLDLDSSLVADYDEVDQEYLEAFVDLF
LEKTTFTFNMFGVKN
>SPy1605 putative two-component responsible histidine kinase
MLEDFLQFLGFIFLDIIEIMLTLKLFSFVSAIPLRLKNIFYLSLSMVLFQ
VVFWAFFPDHFILDVVMLAQFLFFALIALYYGKSIKAKFLMFYAFFPLVS
ISLVKRFIVFFVMPLFGMPYSVVKHNTLLIYSITCFSIFLIYRCIQVFHF
DFSTWRQYFQSHRASKLLVFTNSSMALYYLCVQGIDVMSPSLSGLATTTA
RSIIVLFYFILFLTLLIHLERYVKQNSIEAIVQQKEYRELINYSQHLGLL
YQDIQELRRLLTTVSSRLKIGIEQNDISIVRLTYEGILNAEKNNAKDDRL
DLTCLDKLQVEAIRHIVLAKLIEAKNKKLKVEVSIPNCIATFFLEVVDFT
KLLSFLLDNAIEMSLETKQPCLSIAFLDQNHKLVIVIQSSTKQGQDDSQS
VFAIPALKKRDDWQFDLRNVTTILNRYDYLTISSQIHDGILTQLIEIAKP
D
>SPy1556 putative two-component response regulator
MYSLLIVEDEYLVRQGIRSLVDFSQFKIDRVNEAENGQLAWDLFQKEPYD
IVLTDINMPKLNGIQLAELIKQESPQTHLVFLTGYDDFNYALSALKLGAD
DYLLKPFSKADVEDMLGKLRKKLELSKKTETIQELVEQPQKEVSAIAMAI
HERLADSDLTLKSLAQQLGFSPNYLSVLIKKELGMPFQDYLVQERLKKAK
LLLLTSNLKIYEIAEQVGFEDMNYFSQRFKQLVGVTPSQYKKGGQA
>SPy1061 putative two-component sensor histidine kinase
MRGEQVEEHFKKQLQDDISRHFSYQSLMLSLLLIGLFIIFSLAPQQLGLY
RDINATATRYHRLISKQEALLDDLGKNSLLPFLNKNLSTADLSKHYFHLR
HSSQTSPELLLFSPSQDLLFASNPHLGNVFSKSVYIQEVLRATHSPKTLF
KDAMDSEDGHYLMIIMPMIDQNQLKGYAFLVMSGKDFLHPTKTLTSELVI
ADKLDNTFTFSNREFIASSLDKINSQYLHHYFVFQDNRAFITRKVALQGG
LWLYMYRPLIPMVSVMLFSLISSAVIFVILQRKSSGLANRIAAKNSRAIN
QMVRDMSAISRQEKRRIDLESQDEFQYLSDQINQMVERLQQLHDKTLDLE
TQKLLFEKRMLEAQFNPHFLYNTLETILITSHYDSALTEKIVIQLTKLLR
YSLTDSSKPVLLKDDLSVIESYLVINQVRFEELQYSINLSPDLDSLEVPK
LFLLPLIENAIKYGLKERHDVKINIACYYQDDHIIFSVRDNGSGIDAHHQ
KVIREQLEAGESHHGLINSYRRLKYHFSEVSLVFDQGDKQFNVSYHVKE
>SPy0855 putative fructose-specific enzyme II, PTS system BC component
MKIQDLLRKDIMILDLQAISKEVAIDEMITKLVEKDIVHDFDVFKKSIMT
REEQTSTGLGDGIAMPHSKNIVVDKPAVLFAKSNKGVDYKALDGQPTDLF
FMIAAPQGANDTHLAALAELSQYLLKDGFADKLRAAATPEAVIAVFDEAS
TAKEEVVAPTSGQDFIVAVTACPTGIAHTYMAEEALKKQAAEMGVAIKVE
TNGASGVANRLTAEDIQRAKGVIVAADKAVEMDRFDGKQFIARPVADGIK
KSQELISLILNNEGNTYHAKNGKSETAVSTEKTSLGGAFYKHLMGGVSQM
LPFVIGGGIMIALAFLLDNMLGVPNDQLGSLGSYHEIAAIFMNIGGAAFS
FMLPVLAGYIAYSIAEKPGLVAGFVAGAIASNGLAFGKVPFAAGGEVSLG
LTGVPSGFLGALVGGFLAGGVILALRKLLAGLPRSLEGVKSILLYPLLGV
LVTGFLMLFVNIPMAAINTALNDFLQGLSGSSAVLMGLLVGGMMAVDMGG
PVNKAAYVFGTGTLAATVANGGSVVMAAVMAGGMVPPLAVFVATLLFKDK
FTKEERESGLTNIVMGLSFITEGAIPFGAADPARAIPSFIAGSALTGALV
GLAGIKLMAPHGGIFVIALTSNPILYLVFVVIGALVSGILFGALRKKA
>SPy1548 hypothetical protein
MIRREDYQYLRKLNDFRYFSIEQFDKIVGQMEFRKAKKDHILFFEGDKRD
KLFLVTSGYFKVEQSDQSGTFMYTDFIRHGTIFPYGGLFTDDYYHFSVVA
MTDVTYFYFPVDLFEDYSLENRLQMKHLYSKMSKLLELHELRVRNLITSS
ASSRVIQSLAILLVEMGKDSDTLPFQLTTTDIAQISGTTRETVSHVLRDL
KKQELITIKGKYLTYLDKDYFLQYTK
>SPy0227 hypothetical protein
MSQVIGDLRELIHQIEQISDEIAKKYDVEHLAGPQGYVLVFLAKHQNQEI
FVKDIEKQLRIFQSQLLVI
>SPy2184 conserved hypothetical protein
MKKFRFETIHLIMMGLILFGLLALCVSIMQSKILILLAIFLVLLFVVALL
WYQKEAYQLSDLAHIELLNEQTEDNLKTLLDNMPVGVVQFDQETNAVEWY
NPYAELIFTTEEGFIQNGLIQQIITEKRREDISQTFEVSGNKYTSYIDVS
SGIFYFFDSFVGNRQLADASMLRPVVGIISVDNYDDITDDLSDADTSKIN
SFVANFIDEFMESKRIFYRRVNMDRYYFFTDFKTLNDLMDNKFSVLEEFR
KEAQDAQRPLTLSIGISFGEENHSQIGQVALENLNIALVRGGDQIVIREN
ADHTNPIYFGGGSVSTVKRSRTRTRAMMTAISDRIKMVDNVFIVGHRKLD
MDALGSAVGMQFFAGNIIENSFAVYNPDEMSPDIERAIERLQADGKTRLI
SVSQAMGLVTPRSLLVMVDHSKISLTLSKEFYEQFQNVIVVDHHRRDDDF
PDNAILTFIESGASSAAELVTELIQFQNAKKCLNKIQASVLMAGIMLDTK
NFSTRVTSRTFDVASYLRSKGSDSVEIQNISATDFEEYKQINEIILQGER
LGDSIIVAAGEKNHLYSNVIASKAADTILSMAHVEASFVLVETASHKIAI
SARSRSKINVQRVMEKLGGGGHFNLAACQLTDISLPQAKYLLLKTINMTM
KETGEVES
>SPy0583 hypothetical protein
METKFYKQRKNRLVAGVIAGLADKYGWDLALARVLAALLIYGTGFGVLLY
ILLAIFLPYKEDLLEERYGRGPRRRKDADVLNEEEDGWFW
>SPy0428 conserved hypothetical protein
MLKKRYQLAIVLLLSCFSLIWQTEGLVELFVCEHYERAVCEGTPAYFTFS
DQKGAETLIKKRWGKGLIYPRAEQEAMAAYTCQQAGPINTSLDKAKGELS
QLTPELRDQVAQLDAATHRLVIPWNIVVYRYVYETFLRDIGVSHADLTSY
YRNHQFDPHILCKIKLGTRYTKHSFMSTTALKNGAMTHRPVEVRICVKKG
AKAAFVEPYSAVPSEVELLFPRGCQLEVVGAYVSQDQKKLHIEAYFKGSL
>SPy2145 hypothetical protein-phage associated
MNKKNAIRKLKEFHRWQRIANSLDLTYTELYQFDIEYHPTRRKHLEISRE
CALEELDAIRYAINQLSKVEYRQILIECYLISEEKTQQDIMEELNGSQSW
YYESKKRALLEFVEFYRDGALKNNVHL
>SPy1062 putative two-component response regulator
MYKLVIIEDEHIIRKWLRYAIDYKALDILVIGEAKDGKEGAVLIKESQPD
IVLTDINMPIMTAFDMFEVTKDQTYAKIILSGYADFPNARSAIHYGVLEF
LTKPIEKAALWECLQTIIAKIEKQKGSNQKTDACVYIPLPQMTDQIPEVV
KDILEWVHAHFQDKISTSRLAHDLGYSESYIYQNIKKHLQMPLSDYINQY
RINQAIQLMQQEPDLMVYEIAQAVGIYDYRYFDRVFKKYLGQTVKAFKEE
HFMKDTDRSKPC
>SPy1237 putative response regulator
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILL
DLMLPEKNGFQVLKELREKDIKIPVLIMTAKEGLDDKGHGFELGADDYLT
KPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVEL
LGKEFDLLVYLLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKK
LKGTCFVNRLQTLRSVGYILKNNE
>SPy1273 cfa, CAMP factor
MKPKHLLCLSTVVAGLALFSTMTHSVLADDASNPDAILMNNNQANFQRDA
LVQKLDEGHQQLEAIKHEAKGTDIETTVNKAIDAVDHMKSSIRFNTETIY
DFSSIGARVEALSDAIKAIVFSTTQLTHKVEKAHTDMGFAITKLVIRIID
PFASVDAIKAQVQEIKALEEKVINYPDLQPTDRATIYTKAKLNKAIWNTR
LERDKKVLGIKPFDVYNRLNKAITHAVGVQLNPTTTVQQVDDEVIAVQDA
LETALKS
>SPy0337 csrS, putative sensory transduction histidine kinase
MENQKQKQKKYKNSLPKRLSNIFFVLFFCIFSAFTLIAYSSTNYFLLKKE
KQSVFQAVNIVRVRLSEVDSNFTLENLAEVLYKNDKTHLRIDDRKGSRVI
RSERDITNTLDANQDIYVYNIDKQMIFTTDNEESSPGLHGPIGRVYHDHI
EDQYRGFSMTQKVYSNRTGKFVGYVQVFHDLGNYYVIRARLLFWLLVVEL
FGTSLAYLIILITTRRFLKPLHNLHEVMRNISENPNNLNLRSDISSGDEI
EELSVIFDNMLDKLETHTKLQSRFISDVSHELRTPVAIIKGHIGLLQRWG
KDDSDILEESLTATAHEADRMAIMINDMLDMIRVQGSFEGHQNDMTVLED
SIETVVGNFRVLREDFIFTWQSENPKTIARIYKNHFEQALMILIDNAVKY
SRKEKKIAINLSVTGKQEAIVRVQDKGEGISKEDIEHIFERFYRTDKSRN
RTSTQAGLGIGLSILKQIVDGYHLQMKVESELNEGSVFILHIPLAQSKES
>SPy1978 lrp, leucine-rich protein
MELKDYFPEMQVGPHPLGDKDWMSIKEGDQYVHFPKSCLSEKERLLLEVG
LGQCEVLQPLGSPWQRYLLDHQGNPPQLYETSQFIYLNHQQALPDDLVEL
LQQMIAGLEVILPISATQTAFLCRQAISIKVLRWLEDLLPTLESDFGLAL
TMFVGNAWYQVAAGTLRECFEEECQLLTAYLRQQSGRKLLTFSGLMLWSL
LSHHTFLALTRQFHQFLSPQSDMADVVHALWSEHGNLVQTAQRLYIHRNS
LQYKLDKFAQQSGLHLKQLDDLAFAHLFLLKY
>SPy1642 luxS, autoinducer-2 production protein
MTKEVIVESFELDHTIVKAPYVRLISEEFGPKGDRITNFDVRLVQPNQNS
IETAGLHTIEHLLAKLIRQRIDGMIDCSPFGCRTGFHLIMWGKHSSTDIA
KVIKSSLEEIATGITWEDVPGTTLESCGNYKDHSLFAAKEWAQLIIDQGI
SDDPFSRHVI
>SPy0281 mecA, putative negative regulator of genetic competence
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDL
PDNFKDSGMLSFRVTPRKDRLDVFVTKSEINKDINLEDLAEFGDMSQMTP
EDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTN
HESEPLDYVHYVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILL
DVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLMLDGAVEQLQKI
ELG
>SPy0471 phoH, phosphate starvation-induced protein
MQEYSIDITLTHPDDVLALFGSNERHLKLIEAHLGVIVHARTERVQVIGD
DEEAVELARLTIKALLVLVGRGMVVNTSDVVTALSMAESHQIDQFMALYE
EEIIKDNYGKAIRVKTLGQKTYVDSVKRHDVVFGVGPAGTGKTFLAVTLA
VTALKRGQVKRIILTRPAVEAGESLGFLPGDLKEKVDPYLRPVYDALYHI
LGKEQTTRLMERDVIEIAPLAYMRGRTLDDAFVILDEAQNTTIMQMKMFL
TRLGFNSKMIVNGDTSQIDLPRNVKSGLIDATQKLQGIKQIDFVYFSAKD
VVRHPVVADIIKAYETSSEEMKDLLKPKASDVEADYQPGLTKYPVIGQEH
>SPy1626 pppL, putative phosphoprotein phosphatase
MKISLKTDIGQKRSNNQDFINKFDNKKGITLVILADGMGGHRAGNIASEM
TVTDLGREWVKTDFTELSQIRDWLFETIQSENQRIYDLGQSEDFKGMGTT
VEAVALVESSAIYAHIGDSRIGLVHDGHYTLLTSDHSLVNELVKAGQITE
EEAASHPQRNIITQSIGQASPVEPDLGVRVLEPGDYLVINSDGLTNMISN
DEIVTILGSKVSLDEKNQEMIDLANLRGGLDNITIALVHNESEDVE
>SPy0269 prgA, putative surface exclusion protein
MDLEQTKPNQVKQKIALTSTIALLSASVGVSHQVKADDRASGETKASNTH
DDSLPKPETIQEAKATIDAVEKTLSQQKAELTELATALTKTTAEINHLKE
QQDNEQKALTSAQEIYTNTLASSEETLLAQGAEHQRELTATETELHNAQA
DQHSKETALSEQKASISAETTRAQDLVEQVKTSEQNIAKLNAMISNPDAI
TKAAQTANDNTKALSSELEKAKADLENQKAKVKKQLTEELAAQKAALAEK
EAELSRLKSSAPSTQDSIVGNNTMKAPQGYPLEELKKLEASGYIGSASYN
NYYKEHADQIIAKASPGNQLNQYQDIPADRNRFVDPDNLTPEVQNELAQF
AAHMINSVRRQLGLPPVTVTAGSQEFARLLSTSYKKTHGNTRPSFVYGQP
GVSGHYGVGPHDKTIIEDSAGASGLIRNDDNMYENIGAFNDVHTVNGIKR
GIYDSIKYMLFTDHLHGNTYGHAINFLRVDKHNPNAPVYLGFSTSNVGSL
NEHFVMFPESNIANHQRFNKTPIKAVGSTKDYAQRVGTVSDTIAAIKGKV
SSLENRLSAIHQEADIMAAQAKVSQLQGKLASTLKQSDSLNLQVRQLNDT
KGSLRTELLAAKAKQAQLEATRDQSLAKLASLKAALHQTEALAEQAAARV
TALVAKKAHLQYLRDFKLNPNRLQVIRERIDNTKQDLAKTTSSLLNAQEA
LAALQAKQSSLEATIATTEHQLTLLKTLANEKEYRHLDEDIATVPDLQVA
PPLTGVKPLSYSKIDTTPLVQEMVKETKQLLEASARLAAENTSLVAEALV
GQTSEMVASNAIVSKITSSITQPSSKTSYGSGSSTTSNLISDVDESTQRA
LKAGVVMLAAVGLTGFRFRKESK
>SPy0584 ptsK, Hpr kinase/phosphatase
MTVTVKMLVQKVKLDVVYATDNLLSKEITTSDISRPGLEMTGYFDYYAPE
RLQLFGMKEWSYLTQMTSHNRYSVLKEMFKKDTPAVVVSRNLAIPKEMVQ
AAKEEGISLLSSRVSTSRLAGEMSYFLDASLAERTSVHGVLMDIYGMGVL
IQGDSGIGKSETGLELVKRGHRLVADDRVDVYAKDEETLWGEPAEILRHL
LEIRGVGIIDVMSLYGASAVKDSSQVQLAIYLENFEAGKVFDRLGNGNEE
ITFSGVRIPRIRIPVKTGRNVSVVIEAAAMNHRAKEMGFDATKTFEDRLT
QLITKNEVSQ
>SPy1981 relA, (p)ppGpp synthetase
MRNEMAKIMNVTGEEVIALAATYMTKADVAFVAKALAYATAAHFYQVRKS
GEPYIVHPIQVAGILADLHLDAVTVACGFLHDVVEDTDITLDEIEADFGH
DARDIVDGVTKLGEVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRL
HNMRTLKHLRKDKQERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLN
ETEFYKISHMMKEKRREREALVEAIVSKVKTYTTQQGLFGDVYGRPKHIY
SIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRF
KDYIAAPKANGYQSIHTTVYGPKGPIEIQIRTKDMHQVAEYGVAAHWAYK
KGVRGKVNQAEQAVGMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIY
VFTPTGAVQELPKESGPIDFAYAIHTQIGEKATGAKVNGRMVPLTAKLKT
GDVVEIITNANSFGPSRDWVKLVKTNKARNKIRQFFKNQDKELSVNKGRD
LLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFGDISPIS
VFNKLTEKERREEERAKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQ
GASGLLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHNIKSQDGYQER
LIEVEWDLDNSSKDYQAEIDIYGLNRSGLLNDVLQILSNSTKSISTVNAQ
PTKDMKFANIHVSFGIPNLTHLTTVVEKIKAVPDVYSVKRTNG
>SPy1908 salR, putative response regulator of salavaricin regulon
MKILLIDDHRLFAKSIQLLFQQYDEVDVIDTITSHFNDVTIDLSKYDIIL
LDINLANISKENGLEIAKELIQSTPHLKVVMLTGYVKSIYRERAKKVGAY
GFVDKNIDPKQLISILKKVDSGKKYFEQIESQDYVESLTDQEIAILNLSK
KGFSIKEIEETLQISRRTVFNHLTHIYSKLLVNNKQEAIYKAEQLGYFMD
F
>SPy1082 srtK, putative histidine kinase-lantibiotic associated
MFKKYSIKNRVWRAVVEIVFGVCITVLMIAIISLSFSKLNIVTSHNVGEE
FYIKDKQSIKQLNNYMKTLGLDYVVFDRKTDKAMEGKYLSKEFSLFNEVA
EEKNNLTFNSVHYDLYTNINYNIVIRYNEIPEFSNHYLRNVSYNMLTFYI
LGIGTSISIVVALTRFVKEISLNFKEIKKLANKMGIEVLSENENYSQIIE
FDDILRTLHIKGDNLKSLIEREILEKQDLSFQIAALSHDIKTPLTVLKGN
LELLELTTLNKNQEGYIVSMNNSISVFEGYFNSLISYTRMLSEDRSVKLI
LVEELLSELHFEVDDLLNINNIEFSICNRLIITSFYGDEENLIRALSNLL
VNAIRFMPVLDKKIEVILSESGEQIHFEIWNNGERFSDSTLKKGDKLFYT
EDYSRGNKHYGIGLAFVKGVAIKHGGNLQLNNPARGGASAIISIKKKI
>SPy1081 srtR, putative DNA binding regulatory protein-lantibiotic associated
MYKILAIDDDKEILKLMKTALEIENYHVITCQEIELPIVFDDFKGYDLIL
LDIMMPNISGTEFCYKIREEVHSPIIFVSALDGDNEIVQALNIGGDDFIV
KPFSLKQFVAKVNSHLKREERAKIKNEAEERVKRSFPPIEIYLEERMLYI
DKQPLFLTYREYEILELLSRHPYKVFTKEEIYEQVYSDEASALFHSISEY
IYQIRMKFSSFGINPIKTIRGIGYKWDV
>SPy0529 vicK, two-component sensor histidine kinase
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRD
LINGRYTDIIDEKADIELMELSDQLNDLSDVFRLTHENLAQEKNRLASIL
AYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYT
YRDLVSKTPVVTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTT
EQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALKEDIAPSFIKV
SLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVK
NQHTGTGKVYEIVRDYPITSVWIEIDNDKMTQVIENILNNAIKYSPDGGK
ITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD
>SPy0528 vicR, two-component response regulator
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLII
LDLMLPELDGLEVAKEIRKTSHVPIIMLSAKDSEFDKVIGLEIGADDYVT
KPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAF
VAKKHGQEVELTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRT
VDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD