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# Streptococcus pyogenes M1 GAS, SF370

>SPy0917 hypothetical protein
MPFIAKQTLKSQLIPQDNLLAESRFNEIMDFLTGDFPLVFRPMINPHRYT
ISQDNQALEKVKQASYKRMDIAMTHLDSLIGESGHVYRDQQTIADAYAYA
MALWSQKTPKSYENYPHLAAFMAKMVEDSAVQQVLNAAH
>SPy0123 putative heat shock protein HSP33
MDKIIKSIAQSGAFRAYVLDSTETVALAQEKHNTLSSSTVALGRTLIANQ
ILAANQKGDSKITVKVIGDSSFGHIISVADTKGHVKGYIQNTGVDIKKTA
TGEVLVGPFMGNGHFVTIIDYGTGNPYTSTTPLITGEIGEDFAYYLTESE
QTPSAIGLNVLLDENDKVKVAGGFMVQVLPGASEEEIARYEKRLQEMPAI
SHLLASKNHVDALLEAIYGDEPYKRLSEEPLSFQCDCSRERFEAALMTLP
KADLQAMIDEDKGAEIVCQFCGTKYQFNESDLEAIISDKA
>SPy1558 hypothetical protein
MKKGLLVTTGLACLGLLTACSTQDNMAKKEITQDKMSMAAKKKDKMSTSK
DKSMMADKSSDKKMTNDGPMAPDFELKGIDGKTYRLSEFKGKKVYLKFWA
SWCSICLSTLADTEDLAKMSDKDYVVLTVVSPGHQGEKSEADFKKWFQGT
DYKDLPVLLDPDGKLLEAYGVRSYPTEVFIGSDGVLAKKHIGYAKKSDIK
KTLKGIH
>SPy0850 putative thioredoxin reductase
MKDKAYDITIIGGGPIGLFAAFYAGLRGVTVKIIESLSELGGQPAILYPE
KMIYDIPAYPSLTGVELTENLIKQLSRFEDRTTICLKEEVLTFDKVKGGF
SIRTNKAEHFSKAIIIACGNGAFAPRTLGLESEENFADHNLFYNVHQLDQ
FAGQKVVICGGGDSAVDWALALEDIAESVTVVHRRDAFRAHEHSVELLKA
STVNLLTPYVPKALKGIGNLAEKLVIQKVKEDEVLELELDSLIVSFGFST
SNKNLKNWNLDYKRSSITVSPLFQTSQEGIFAIGDAAAYNGKVDLIATGF
GEAPTAVNQAINYIYPDRDNRVVHSTSLID
>SPy1884 similar to several eukaryotic hypersensitive-induced response proteins
MLGPFIFIAFGVIVILAIVASTLYVVRQQSVAIVERFGRYQKTATSGIHI
RLPFGIDKIAARVQLRLLQSEIIVETKTKDNVFVTLNVATQYRVNEQNVT
DAYYKLMKPESQIKSYIEDALRSSVPKLTLDELFEKKDEIALEVQHQVAE
EMSTYGYIIVKTLITKVEPDAEVKQSMNEINAAQRKRVAAQELANADKIK
IVTAAEAEAEKDRLHGVGIAQQRKAIVDGLAESIQELKEANISLNEEQIM
SILLTNQYLDTLNTFAAKGNQTLFLPNTPSGVEDIRTQVLSALKTK
>SPy1874 putative glycoprotein endopeptidase
MKTLAFDTSNKTLSLAILDDETLLADMTLNIQKKHSVSLMPAIDFLMTCT
DLKPQDLERIVVAKGPGSYTGLRVAVATAKTLAYSLNIALVGISSLYALA
ASTCKQYPNTLVVPLIDARRQNAYVGYYRQGKSVMPQAHASLEVIIEQLV
EEGQLIFVGETAPFAEKIQKKLPQAILLPTLPSAYECGLLGQSLAPENVD
AFVPQYLKRVEAEENWLKDNEIKDDSHYVKRI
>SPy1532 hypothetical protein
MIAFFSICSGILLTHLFYCLLLYFPDNGQEQLSKQTVIVCDQLTFAKRVF
RQFQNHFITSQKIFFSLEIGLIIILWASMVHWVSASYCYLLLFSLLFSLF
DWRSQEYPFILWLFSFVSLLLFYSINYLSLILLLLGLLAHLRPFSIGAGD
FFYLASLALVLDLTSLIWLIQLASLAGITACLLLGIKRIPFIPYLSFGLF
WIVLLEHF
>SPy0591 putative protease
MSHMKKRPEVLSPAGTLEKLKVAIDYGADAVFVGGQAYGLRSRAGNFSME
ELQEGIDYAHARGAKVYVAANMVTHEGNEIGAGEWFRQLRDMGLDAVIVS
DPALIVICSTEAPGLEIHLSTQASSTNYETFEFWKAMGLTRVVLAREVNM
AELAEIRKRTDVEIEAFVHGAMCISYSGRCVLSNHMSHRDANRGGCSQSC
RWKYDLYDMPFGGERRSLKGEIPEDYSMSSVDMCMIDHIPDLIENGVDSL
KIEGRMKSIHYVSTVTNCYKAAVGAYMESPEAFYAIKEELIDELWKVAQR
ELATGFYYGIPTENEQLFGARRKIPQYKFVGEVVAFDSASMTATIRQRNV
IMEGDRIECYGPGFRHFETVVKDLHDADGQKIDRAPNPMELLTISLPREV
KPGDMIRACKEGLVNLYQKDGTSKTVRT
>SPy0287 conserved hypothetical protein
MTKEKLVAFSQAHAEPAWLQERRLAALEAIPNLELPTIERVKFHRWNLGD
GTLTENESLASVPDFIAIGDNPKLVQVGTQTVLEQLPMALIDKGVVFSDF
YTALEEIPEVIEAHFGQALAFDEDKLAAYHTAYFNSAAVLYVPDHLEITT
PIEAIFLQDSDSDVPFNKHVLVIAGKESKFTYLERFESIGNATQKISANI
SVEVIAQAGSQIKFSAIDRLGPSVTTYISRRGRLEKDANIDWALAVMNEG
NVIADFDSDLIGQGSQADLKVVAASSGRQVQGIDTRVTNYGQRTVGHILQ
HGVILERGTLTFNGIGHILKDAKGADAQQESRVLMLSDQARADANPILLI
DENEVTAGHAASIGQVDPEDMYYLMSRGLDQETAERLVIRGFLGAVIAEI
PIPSVRQEIIKVLDEKLLNR
>SPy2055 putative pyruvate formate-lyase activating enzyme
MTDRGIVFNIQHFSIHDGPGIRTTVFLKGCPLRCPWCANPESQQKAPEQM
LTSDGLNTKIVGEEKTVDEVIEEVLKDLDFYEESGGGMTLSGGEIFAQFD
FALALLKAAKAAGLHTAIETTAFAKHEQFVTLVDYVDFIYTDLKHYNQLR
HQKVTGVRNDLIIKNIHYAFQAGKEIVLRIPVIPQFNDSLDDAKAFSELF
NQLEIDQVQLLPFHQFGENKYKLLGREYEMAEVKAYHPEDLADYQAVFLN
HNIHCYF
>SPy1971 conserved hypothetical protein
MRPKEKETSMTFEEIVANFIPSSVAEVTSAIASGKDMIVFLGRSSCPYCR
RFAPKLAQVATDNQKEVYFVDSENAADAAELAAFRENYQLVTVPALLVSY
DQHQRAVCDSSLTPDDILAFLTRE
>SPy1322 hypothetical protein
MIISAEGDVSIHHCFEAMLISLQEDYRQNTLRQLSRDDIKAGINYVKHYG
KYKERTVRVLITALEAPQLYTACFSSNHGIKELAYQLEALGENRTRITYS
YDYHPLDIFQKANQFIVGKLFKKSLERQSQAQLAALIQYAKQLQQPSSL
>SPy0290 conserved hypothetical protein
MSDINEKVEPKPIDLGDYQFGFHDDVEPIYSTGKGLSEAVVRELSAAKNE
PEWMLEFRLKSLETFNKMPMQTWGADLSDINFDDIIYYQKASDKPARSWD
DVPEKIKETFDRIGIPEAERAYLAGASAQYESEVVYHNMKGEFEKLGIIF
TDTDSALKEYPDLFKQYFAKLVPPTDNKLAALNSAAWSGGTFIYVPKGVK
VDIPLQTYFRINNENTGQFERTLIIVDEGASVHYVEGCTAPTYSSNSLHA
AIVEIFALDGAYMRYTTIQNWSDNVYNLVTKRARALTDATVEWIDGNLGA
KTTMKYPSVYLDGPGARGTMLSIAFANAGQHQDTGAKMIHNAPHTSSSIV
SKSIAKSGGKVDYRGQVTFNKQSKKSVSHIECDTILMDDISKSDTIPFNE
IHNSQVALEHEAKVSKISEEQLYYLMSRGLSESEATEMIVMGFVEPFTKE
LPMEYAVELNRLISYEMEGSVG
>SPy1791 putative ABC transporter (ATP-binding protein)
MMETEDTISRGKRKRLLKRLRERIAPKRYLLYVSAFLSWLQFVMRMISFY
LIAKTFSTFILGHAIALGRLAGLLLLLNVVGFVLAILGKQLQGIASQFAR
DSLKQSFFEAFIDLDGQFDAHASDADILTLASQGIDSLDTYYGYYLSLSM
RTKWNCTTIMILVFLIYPLAGLVFLGVLPLIPLSIVAMQKRSQPNMSHYW
SSYMDVGNLFMDDLKGLNTLYSYQATERYEQEFSGKAEQFRKATMSLLGF
QLQAVGYMDAVMYLGIGLSGFLAVQALATGQLSFFNFLFFLLIATEFFTP
IREQGYGMHLVMMNTKMADRIFSFLDSVPARKDNKSKTAINFNQIDIQNI
SLAYEKKTVLSGVTMTLTKGQLTAIAGVSGQGKTSLAQLLLKRQSATTGH
ILFDGLDSDNLSQETINQQVLYVSDQSTLLNRSIYDNLRLAANLSKKEIL
DWIDQHGLLSFINWLPDGLDTIVGENGNLLSPGQKQQVICARALLSKRSL
YIFDEATSSLDAENERIIDNLITRLAKTAIVIVITHKMSRLKGANQVLFL
NTGQPACLGKPCDLYRDQPTYRHLVDTQARLEASIYG
>SPy0504 conserved hypothetical protein
MAKGEGHILAQNKKARHDYHIVETVEAGIVLTGTEIKSVRAARIQLKDGF
AQIKNGEAWLVNVHIAPFEQGNIWNADPERTRKLLLKKREITHLANELKG
SGMTLVPLKVYLKDGFAKVLIGLAKGKHEYDKRETIKRRDQERDIKKQMK
HYNAR
>SPy1390 putative protease maturation protein
MKNSNKLIASVVTLASVMALAACQSTNDNTKVISMKGDTISVSDFYNETK
NTEVSQKAMLNLVISRVFEAQYGDKVSKKEVEKAYHKTAEQYGASFSAAL
AQSSLTPETFKRQIRSSKLVEYAVKEAAKKELTTQEYKKAYESYTPTMAV
EMITLDNEETAKSVLEELKAEGADFTAIAKEKTTTPEKKVTYKFDSGATN
VPTDVVKAASSLNEGGISDVISVLDPTSYQKKFYIVKVTKKAEKKSDWQE
YKKRLKAIIIAEKSKDMNFQNKVIANALDKANVKIKDKAFANILAQYANL
GQKTKAASESSTTSESSKAAEENPSESEQTQTSSAEEPTETEAQTQEPAA
Q
>SPy0457 putative cyclophilin-type protein
MKKLLSLSLVAISLLNLSACESVDRAIKGDKYIDEKTAKEESEAASKAYE
ESIQKALKADASQFPQLTKEVGKEEAKVVMRTSQGDITLKLFPKYAPLAV
ENFLTHAKKGYYDNLTFHRVINDFMIQSGDPKGDGTGGESIWKGKDPKKD
AGNGFVNEISPFLYHIRGALAMANAGANTNGSQFYINQNKKNQSKGLSST
NYPKPIISAYEHGGNPSLDGGYTVFGQVIDGMDVVDKIAATSINQNDKPE
QDITITSIDIVKDYRFKN
>SPy1872 putative glycoprotein endopeptidase
MTDRYILAVESSCDETSVAILKNESTLLSNVIASQVESHKRFGGVVPEVA
SRHHVEVITTCFEDALQEAGISASDLSAVAVTYGPGLVGALLVGLAAAKA
FAWANHLPLIPVNHMAGHLMAAREQKPLVYPLIALLVSGGHTELVYVPEP
GDYHIIGETRDDAVGEAYDKVGRVMGLTYPAGREIDQLAHKGQDTYHFPR
AMITEDHLEFSFSGLKSAFINLHHNAKQKGDELILEDLCASFQAAVLDIL
LAKTKKALSRYPAKMLVVAGGVAANQGLRDRLAQEITHIEVVIPKLRLCG
DNAGMIALAAAIEYDKQHFANMSLNAKPSLAFDQFPDSFVIN
>SPy0505 putative glutamine cyclotransferase
MSIMITKGQVRLLRTYSYDSNLYTQGLEQLNNNHILLSAGRYGFSKVGVY
DLTQEIFSEKIAFPDTVFAEGLTVVEDYFWLLTYKEGVAYKFDKATCNCL
GAYPFEGDGWGLAYDKENQCLWMTSGNAFLQKRDPKDFALLDTVLVAIES
VPISMLNELEYVDGYLYANIWQTNTIVKLQPDSGKVVATYDISPLLKALN
LDKSHYPDLNVLNGIAHLDQQRFLITGKLYPLMLEVVLD
>SPy2037 conserved hypothetical
MKQMNKLITGVVTLATVVTLSACQSSHNNTKLVSMKGDTITVSDFYNETK
NTELAQKAMLSLVISRVFETQYANKVSDKEVEKAYKQTADQYGTSFKTVL
AQSGLTPETYKKQIRLTKLVEYAVKEQAKNETISKKDYRQAYDAYTPTMT
AEIMQFEKEEDAKAALEAVKAEGADFAAIAKEKTTAADKKTTYTFDSGET
TLPAEVVRAASGLKEGNRSEIITALDPATSKRTYHIIKVTKKATKKADWK
AYQKRLKDIIVTGKLKDPDFQNKVIAKALDKANVKIKDKAFANILAQFAK
PNQKQPAQK
>SPy0590 putative protease
MEKIIITATAESIEQVKALLAAGVDRIYVGEANYGLRLPHNFSYDELRQI
AKLVHDAGKELTVACNALMHQDMMDQIKPFLDLMIEIAVDYLVVGDAGVF
YVNKRDGYNFKLIYDTSVFVTSSRQVNFWGQHGAVESVLAREIPSAELFT
LAENLEFPAEVLVYGASVIHHSKRPLLENYYHFTKIDDEVSRERGLFLAE
PGDASSHYSIYEDNHGTHIFINNDIDMMSKLGELYAHGLTHWKLDGIYCP
GDDFVAITKLFIQAKTLLEAGQFTQEEAEKLDQAVHAHHPAGRGLDTGFY
EFDPKTVK
>SPy1193 hypothetical protein
MPKRIRKALGVVGKLMSIVPDTTEIIGKTIDNSRPIIEKRMEQKHEKEMQ
LRTINDVINLPVDQAQAHLEQLGFVVATIPAKPHKKWLHSNLNEVVAMSP
KSGKYKIGSLIKLYYITVDVLEKSQDLLDQENLRTVERNQKIADTFESVK
HIRFPFKKWR
>SPy2079 ahpC, putative alkyl hydroperoxidase
MSLIGKEIAEFSAQAYHDGKFITVTNEDVKGKWAVFCFYPADFSFVCPTE
LGDLQEQYETLKSLGVEVYSVSTDTHFVHKAWHDDSDVVGTITYPMIGDP
SHLISQAFEVLGEDGLAQRGTFIVDPDGIIQMMEINADGIGRDASTLIDK
IHAAQYVRKHPGEVCPAKWKEGAETLTPSLDLVGKI
>SPy0605 bsaA, putative glutathione peroxidase
MPNLYDFTVKAQDGSDISLVDYKEKVVLVVNTATKCGLTPQYQALQALYD
TYHDKGFEVLDFPCNQFLNQAPGDAEEINHFCSLTYHTTFPRFAKIKVNG
KDADPLFTWLKEEKSGPLGKRIEWNFTKFLIDQNGQVIKRYSSKTDPKLI
EEDLKALLG
>SPy1559 ccdA, putative cytochrome C-type biogenesis protein
MTLSLVLMVSVFGAGLLSFFSPCIFPVLPVYLGILLDADDSKTITIFGKK
LYWYGIVKTLAFIFGLSTIFVILGYGAGFLGNILYAVWFRYLLGALVIIL
GIHQMGLITIKSLQFQKSLTFHNNKNRNGLFNAFILGLTFSFGWTPCVGP
VLSSVLALVASGGNGAWQGGVLMIIYTLGLGIPFLLISFASGIVLKQFNK
LKPHILLLKKVGGVLIIVMGILLMTGTLNNLAQLFG
>SPy2073 clpC, putative endopeptidase Clp ATP-binding chain C
MIMYSTKMQDIFRQAQFQAARFDSHCLETWHVLLAMVAVDNSLANMILSE
YDAQVAIEEYEAAAILAMGKTPKEQLSRVDFRPQSKTLTNLLAFAQAISQ
ITRDQEVGSEHVLFAILLNPDIMASRLLEIAGYQIKDNGNGQPRLADLRK
AIERHAGYSKEMIKAIHELRKPKKTKTQGTFSDMMKPPSTAGELSDFTRD
LTEMARQGLLESVIGRDQEVSRMIQVLSRKTKNNPVLVGDAGVGKTALAY
GLAQRIANGAIPYELKEMRVLELDMMSVVAGTRFRGDFEERMNQIIDDIE
ADGQIILFVDELHTIMGSGSGIDSTLDAANILKPALSRGTLHMVGATTQE
EYQKHIEKDAALSRRFAKILIEEPNTEDAYQILMGLKLSYETYHNVSISN
EAVKTAVKMAHRYLTSKNLPDSAIDLLDEASAAVQNMVKKSAPETLTPID
QALINGDMKKVSRLLAKEAKGQMRKPTPVTEDDILATLSKLSGIPLEKLT
QADSKKYLNLEKELHKRVIGQDAAVTAISRAIRRNQSGIRTGKRPIGSFM
FLGPTGVGKTELAKALAEVLFDDEAALIRFDMSEYMEKFAASRLNGAPPG
YVGYDEGGELTQKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDDGILTDS
RGRKVDFSNTIIIMTSNLGATALRDDKTVGFGVKDIHQDHQAMEKRILEE
LRKTYRPEFINRIDEKVVFHSLTQDNMRDVVKIMVQPLITTLAEKGITLK
IQPLALKHLSEVGYDEHMGARPLRRTLQTEIEDKLSELILSRELTSGHTL
KIGLSHGKLTFHIA
>SPy1509 clpE, putative ATP-dependent protease
MLCQNCNLNESTIHLYTSVNGKQRQVDLCQNCYQIMKSDPANSILNGLTP
GYRAQDRSTSPFFDDFFGDLNNFRAFGNLPNTPPTQAGQNGNGGGRYGGN
YNGQRPAQPQTPNQQAKGLLEEFGINVTDIARNGNIDPVIGRDEEITRVI
EILNRRTKNNPVLIGEPGVGKTAVVEGLAQKIIDGTVPQKLQGKQVIRLD
VVSLVQGTGIRGQFEERMQKLMEEIRNRKDVILFIDEIHEIVGAGSAGDG
NMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPS
VEETITILKGIQPKYEDYHHVKYSPAAIEAAAHLSNRYIQDRFLPDKAID
LLDEAGSKMNLTLNFVDPKEIDKRLIEAENLKAQATRDEDYERAAYFRDQ
ITKYKEMQAQKVDEQDIPIITEKTIEAIVEQKTNIPVGDLKEKEQSQLVN
LANDLKAHVIGQDDAVDKIAKAIRRNRVGLGTPNRPIGSFLFVGPTGVGK
TELSKQLAIELFGSTNNMIRFDMSEYMEKHAVAKLVGAPPGYIGYEEAGQ
LTEQVRRNPYSLILLDEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKD
TIIIMTSNAGTGKSEASVGFGAAREGRTSSVLGELSNFFSPEFMNRFDGI
IEFKALSKEHLLHIVDLMLEDVNERLGYNGIHLDVTQKVKEKLVDLGYDP
KMGARPLRRTIQDYIEDAITDYYLEHPTEKQLRALMTNSENITIKAVKEG
DSFLNEESLD
>SPy0888 clpL, putative ATP-dependent Clp proteinase (ATP-binding subunit)
MTHFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYR
QTGQLPVATTKATNSQMLTPKADSVLTQLGTNLTQEARQGHLDPVIGRNK
EIQDTAEILARRTKNNPVLVGDAGVGKTAVIEGLAQAIVNGDVPAAIKNK
EIVSIDISSLEAGTQYRGSFEETIQNLIQEVKEAGNIILFFDEIHQIVGA
GATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTILKNAALARRF
NEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQ
RSLPDKAIDLLDMTAAHLAAQHPVTDLKTLETEIAKQKESQEKAVAKEDF
EKALAAKTRIETLQKQIEQHNQSQNVTATVNDIAESVERLTGIPVSNMGT
NDLERLKGISSRLKSHVIGQDEAVAAVARAIRRNRAGFDDGKRPIGSFLF
VGPTGVGKTELAKQLALDLFGSKDAIIRLDMSEYNDRTAVSKLIGTTAGY
VGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQVLDDGRLTDG
QGNTINFKNTVIIATSNAGFGQQDTETSESNIMDRIAPYFRPEFLNRFNS
IIKFNHLQKESLEEIVDLMLAEVNQTTAKKGISLTITDDAKAHLIDLGYN
HAMGARPLRRIIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIRQNDQ
>SPy0395 clpP, putative ATP-dependent protease proteolytic subunit
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLD
AQDNTKDIYLYVNTPGGSVSAGLAIVDTMNFIKADVQTIVMGMAASMGTV
IASSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRHRL
EKILAQNAGKTIKQIHKDAERDYWMSAEETLAYGFIDEIMENNELK
>SPy0885 clpX, putative ATP-dependent Clp protease subunit X
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEEL
AEEVLADLTEVPKPKELLDVLNQYVVGQDRAKRALSVAVYNHYKRVSFTE
SRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEA
GYVGEDVENILLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRD
VSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTKNILFIVGGAF
DGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFI
GRLPVVAALEQLNTSDLIQILTEPRNALVKQYQALLSYDGVELAFDKEAL
EAIANKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA
>SPy1055 csrA, putative heavy metal stress response protein
METSDELKQRIGDLSYEVTQHAATESPFTGEYDNFFEKGIYVDIVSGEVL
FSSLDKFNSGCGWPAFSKPIENRMVTNHDDSSYGMRRVEVKSREAGSHLG
HVFSDGPKEAGGLRYCINSAALKFIPYDQMEKEGYAQWLTLFDET
>SPy1759 dnaJ, heat-shock (chaperone) protein
MNNTEYYDRLGVSKDASQDDIKKAYRKMSKKYHPDINKEAGAEQKYKDVQ
EAYETLSDSQKRAAYDQYGAAGAQGGFGGGAGGFGGFDGGGFGGFEDIFS
SFFGGGGSRNPNAPRQGDDLQYRVNLSFEEAVFGVEKEVSYNREATCGTC
LGSGAKPGTAPVTCRKCHGSGVMTIDTQTPLGMMRRQVTCDICHGSGKEI
KEPCQTCHGTGHEKQAHKVSVKIPAGVETGQQIRLQGQGEAGFNGGPYGD
LFVILNVLPSKQFERNGSTIYYNLDISFTQAALGDTVEIPTVHGDVEMAI
PAGTQTGKTFRLKGKGAPKLRGGGQGDQHVTVNIVTPTKLNDAQREALQA
FAEASGEKMLHPKKKGFFDKVKDALEDI
>SPy1760 dnaK, heat shock protein 70
MSKIIGIDLGTTNSAVAVLEGTESKIIANPEGNRTTPSVVSFKNGEIIVG
DAAKRQAVTNPETVISIKSKMGTSEKVSANGKEYTPQEISAMILQYLKGY
AEDYLGEKVEKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAA
LAYGMDKTDKDEKILVFDLGGGTFDVSILELGDGVFDVLATAGDNKLGGD
DFDQKIIDFLVAEFKKENGIDLSQDKMALQRLKDAAEKAKKDLSGVTQTQ
ISLPFITAGSAGPLHLEMSLSRAKFDDLTRDLVERTKTPVRQALSDAGLS
LSEIDEVILVGGSTRIPAVVEAVKAETGKEPNKSVNPDEVVAMGAAIQGG
VITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSKSQVFSTAA
DNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGIPQIEVTFDIDK
NGIVSVKAKDLGTQKEQHIVIKSNDGLSEEEIDRMMKDAEANAEADAKRK
EEVDLKNEVDQAIFATEKTIKETEGKGFDTERDAAQSALDELKAAQESGN
LDDMKAKLEALNEKAQALAVKMYEQAAAAQQAAQGAEGAQANDSANNDDV
VDGEFTEK
>SPy0015 ftsH, putative cell division protein
MKNNKNNGFVKNSFIYILMIIVVITGFQFYLKGTSTQSQQISYSKLIKHL
KAGDIKSLSYQPSGSIIEVKGKYEKPQKVTVNSGLSFLGGRASTQVTEFS
SLVLPSDTILKEMTAAADKNGTELTVKQESSSGTWITFLMSFLPIVIFAA
FMMMMMNQGGGGARGAMSFGKNKAKSQSKGNVKVRFTDVAGAEEEKQELV
EVVDFLKNPKKYKSLGARIPAGVLLEGPPGTGKTLLAKAVAGEAGVPFFS
ISGSDFVEMFVGVGASRVRSLFEDAKKAERAIIFIDEIDAVGRRRGAGMG
GGNDEREQTLNQLLIEMDGFEGNENIIVIAATNRSDVLDPALLRPGRFDR
KVLVGRPDVKGREAILRVHAKNKPLANDVNLKVVAQQTPGFVGADLENVL
NEAALVAARRNKIKIDASDIDEAEDRVIAGPSKKDRTISQKEREMVAYHE
AGHTIVGLVLSNARVVHKVTIVPRGRAGGYMIALPKEDQMLLSKEDLKEQ
LAGLMGGRVAEEIVFNAQTSGASNDFEQATQIARAMVTEYGMSEKLGPVQ
YEGNHAMMPGQISPEKAYSAQTAQMIDDEVRELLNQARNQAADIINENRD
THKLIAEALLKYETLDAAQIKSIYETGKMPVDLETDDNEAHALSYDEIKN
KMTESESAE
>SPy2070 groEL, heat shock protein (chaperonin)
MAKDIKFSADARAAMVRGVDMLADTVKVTLGPKGRNVVLEKAFGSPLITN
DGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVH
EGLKNVTAGANPIGIRRGIETATATAVEALKAIAQPVSGKEAIAQVAAVS
SRSEKVGEYISEAMERVGNDGVITIEESRGMETELEVVEGMQFDRGYLSQ
YMVTDNEKMVADLENPFILITDKKVSNIQDILPLLEEVLKTNRPLLIIAD
DVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGTVIT
EDLGLELKDATMTALGQAAKITVDKDSTVIVEGSGSSEAIANRIALIKSQ
LETTTSDFDREKLQERLAKLAGGVAVIKVGAPTETALKEMKLRIEDALNA
TRAAVEEGIVAGGGTALITVIEKVAALELEGDDATGRNIVLRALEEPVRQ
IALNAGYEGSVVIDKLKNSPAGTGFNAATGEWVDMIKTGIIDPVKVTRSA
LQNAASVASLILTTEAVVANKPEPATPAPAMPAGMDPGMMGGF
>SPy2072 groES, heat shock protein-cochaperonin
MLKPLGDRVVVRFDDEKEQTVGGFVLAGTHKESTRKATVLAVSETGVRTI
TGDSVLPSVSVGQEVLVENGHDLEVTVDDEKVSIIRESDIIAIVTK
>SPy1761 grpE, putative Hsp-70 cofactor
MAVFNKLFKRRHSVSEEIKKDDLQEEVEATETEETVEEVIEETPEKSELE
LANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSL
DNLERALAVEGLTDDVKKGLEMTRDSLIQALKEEGVEEVEVDSFDHNFHM
AVQTLPADDEHPADSIAEVFQKGYKLHERLLRPAMVVVYN
>SPy0331 htpX, putative heat shock protein
MLYQQISQNKQRTVVLLVGFFALLALIGASAGYLLLDNYAMGLVLALVIG
VIYATSMIFQSTSLVMSMNNAREVTEKEAPGFFHIVEDMAMVAQIPMPRV
FIIEDPSLNAFATGSSPQNAAVAATTGLLEVMNREELEGVIGHEISHIRN
YDIRISTIAVALASAVTVISSIGGRMLWYGGGSRRQRDDGDDDVLRIITL
LLSLLSLLLAPLVASLIQLAISRQREYLADASSVELTRNPQGMIKALEKL
QLSQPMKHPVDDASAALYINEPRKKRSFSSLFSTHPPIEERIERLKNM
>SPy2216 htrA, putative serine protease
MPSMKHILKSLSILLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMV
FNNTTNTTKAVKAVQNAVVSVINYQDNPSSSLSNPYTKLFGEGRSKENKD
AELSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGEL
VGADTYSDLAVVKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYAN
SVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNSGGPLINIEGQ
VIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIR
PALGISMVNLNDLSTNALSQINIPTSVTGGIVVAEVKEGMPASGKLAQYD
VITEIDGKTVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTT
QDLTKTQ
>SPy0281 mecA, putative negative regulator of genetic competence
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDL
PDNFKDSGMLSFRVTPRKDRLDVFVTKSEINKDINLEDLAEFGDMSQMTP
EDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTN
HESEPLDYVHYVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILL
DVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLMLDGAVEQLQKI
ELG
>SPy1557 msrA, putative peptide methionine sulfoxide reductase
MEHKWKLWLFIVGVVLLIGGASVLIQKGQAKAFSQGKPQLPAKKVKSTKV
DPNAPVDQKVIYLAGGCFWGVEEYFSQVDGVLDAVSGYANGRGDTTNYQL
IHQTGHAETVEVAYDANRISLKELLLHFFRIIDPTSLNKQGNDRGSQYRT
GIYYTDKADLAIIDEVFKEKAKDYKKKIVVEKAPLKHFIKAEDYHQDYLK
KNPNGYCHIDINQATYPVIDESKYPKPSATEIKEKLSADEYRVTQKNETE
KAFSNRYWDSFDAGIYVDVVTGEPLFSSKDKFESGCGWPSFSRPISPDVV
RYKEDKSFNMTRTEVRSRSGNSHLGHVFTDGPKDQGGLRYCINSLSITFI
PKADMEAKGYGYLLSSVE
>SPy0466 msrA.2, putative peptide methionine sulfoxide reductase
MERAIFAGGCFWCMVQPFEEQAGILSVRSGYTGGHLPNPSYEQVCAKTTG
HTEAVEIIFDPKQIAYKDLVELYWTQTDPTDAFGQFEDRGDNYRPVIYYT
TERQKEIAEQSKANLQASGRFDQPIVTTIEPAEPFYLAEDYHQGFYKKNP
KRYAQSSAIRHQFLEENWS
>SPy2080 nox1, putative NADH oxidase/alkyl hydroperoxidase reductase
MALSPDIKEQLAQYLTLLEADLVLQVSLGDNEQSQKVKDFVEEIAAMSER
ISIENITLDRQPSFKVAKKGHGSGVVFAGLPLGHELTSFILALLQVSGRA
PKVDQDVIDRIKAIDRPLHFETYVSLTCHNCPDVVQALNIMSVLNDKISH
TMVEGGMFQDEVKAKGIMSVPTVFLDGEEFTSGRATIEQLLEQIAGPLSE
EAFADKGLYDVLVIGGGPAGNSAAIYAARKGLKTGLLAETFGGQVMETVG
IENMIGTLYTEGPKLMAEVEAHTKSYDVDIIKAQLATSIEKKENIEVTLA
NGAVLQAKTAILALGAKWRNINVPGEDEFRNKGVTYCPHCDGPLFEGKDV
AVIGGGNSGLEAALDLAGLAKHVYVLEFLPELKADKVLQDRAAKTNNMTI
IKNVATKDIVGEDHVTGLNYTERDSGEDKHLDLEGVFVQIGLVPNTAWLK
DSGVNLTDRGEIIVDKHGSTNIPGIFAAGDCTDSAYKQIIISMGSGATAA
IGAFDYLIRQ
>SPy2105 nrdG, putative anaerobic ribonucleotide reductase activator
MAEKCWNNPKPKEWQAEELSQGRIIDYKAFNFVDGEGVRNSLYVSGCLFH
CKGCYNAATWSFKAGMPYTQELEEQIMTDLAQPYVQGLTLLGGEPFLNTG
ILIPLIKRIRRELPEKDIWSWTGYTWEEMMLETPDKLEMLSLIDILVDGR
FDITKKNLMLQFRGSSNQRIIDVQKSLAAKEVIIWDKLNDGDQTFEQISR
EDLL
>SPy1374 nrdH, putative glutaredoxin
MITVYSKNNCMQCKMTKKFLEQHGVNFQEINIDEHPEKVDYVKSLGFTSA
PVIEADNLVFSGFQPAKLKELI
>SPy0506 pcp, putative pyrrolidone carboxyl peptidase
MKILVTGFDPFGGEAINPALEAIKKLPATIHGAEIKCIEVPTVFQKSADV
LQQHIESFQPDAVLCIGQAGGRTGLTPERVAINQDDARIPDNEGNQPIDT
PIRADGKAAYFSTLPIKAMVAAIHQAGLPASVSNTAGTFVCNHLMYQALY
LVDKYCPNAKAGFMHIPFMMEQVVDKPNTAAMNLDDITRGIEAAIFAIVD
FKDRSDLKRVGGATH
>SPy2095 pepO, putative endopeptidase O
MTTYQDDFYQAVNGKWAETAVIPDDKPRTGGFSDLADEIEALMLDTTDAW
LAGENIPDDAILKNFVKFHRLVADYAKRDEVGVSPILPLIEEYQSLKSFS
EFVANIAKYELAGLPNEFPFSVAPDFMNAQLNVLWAEAPSILLPDTTYYE
EGNEKAEELRGIWRQSQEKLLPQFGFSTEEIKDLLDKVIELDKQLAKYVL
SREEGSEYAKLYHPYVWADFKKLAPELPLDSIFEKILGQVPDKVIVPEER
FWTEFAATYYSEANWDLLKANLIVDAANAYNAYLTDDIRVESGAYSRALS
GTPQAMDKQKAAFYLAQGPFSQALGLWYAGQKFSPEAKADVESKVARMIE
VYKSRLETADWLAPATREKAITKLNVITPHIGYPEKLPETYAKKVIDESL
SLVENAQNLAKITIAHTWSKWNKPVDRSEWHMPAHLVNAYYDLQQNQIVF
PAAILQEPFYSLDQSSSANYGGIGAVIAHEISHAFDTNGASFDEHGSLND
WWTQEDYAAFKERTDKIVAQFDGLESHGAKVNGKLTVSENVADLGGVACA
LEAAQSEEDFSARDFFINFATIWRMKAREEYMQMLASIDVHAPGELRTNV
TLTNFDAFHETFDIKEGDAMWRAPKDRVIIW
>SPy0379 pflC, putative pyruvate-formate lyase activating enzyme
MTEKDYGQVTGMVHSTESFGSVDGPGIRFIIFLQGCKLRCQYCHNPDTWE
METNNSKIRTVNDVLKEALQYKHFWGKKGGITVSGGEAMLQIDFITALFI
EAKKLGIHTTLDTCGFTYRPTPEYHQVLDNLLAVTDLILLDLKEIDEKQH
KIVTRQPNKNILQFARYLSDKQIPVWIRHVLVPGLTDIDDHLTRLGEFVK
TLKNVDKFEVLPYHTMGEFKWRELGIPYQLEGVKPPTKERVQNAKNLMQT
ESYTEYMNRIHQS
>SPy0416 prtS, putative cell envelope proteinase
MEKKQRFSLRKYKSGTFSVLIGSVFLVMTTTVAADELSTMSEPTITNHAQ
QQAQHLTNTELSSAESKSQDTSQITLKTNREKEQSQDLVSEPTTTELADT
DAASMANTGSDATQKSASLPPVNTDVHDWVKTKGAWDKGYKGQGKVVAVI
DTGIDPAHQSMRISDVSTAKVKSKEDMLARQKAAGINYGSWINDKVVFAH
NYVENSDNIKENQFEDFDEDWENFEFDAEAEPKAIKKHKIYRPQSTQAPK
ETVIKTEETDGSHDIDWTQTDDDTKYESHGMHVTGIVAGNSKEAAATGER
FLGIAPEAQVMFMRVFANDIMGSAESLFIKAIEDAVALGADVINLSLGTA
NGAQLSGSKPLMEAIEKAKKAGVSVVVAAGNERVYGSDHDDPLATNPDYG
LVGSPSTGRTPTSVAAINSKWVIQRLMTVKELENRADLNHGKAIYSESVD
FKDIKDSLGYDKSHQFAYVKESTDAGYNAQDVKGKIALIERDPNKTYDEM
IALAKKHGALGVLIFNNKPGQSNRSMRLTANGMGIPSAFISHEFGKAMSQ
LNGNGTGSLEFDSVVSKAPSQKGNEMNHFSNWGLTSDGYLKPDITAPGGD
IYSTYNDNHYGSQTGTSMASPQIAGASLLVKQYLEKTQPNLPKEKIADIV
KNLLMSNAQIHVNPETKTTTSPRQQGAGLLNIDGAVTSGLYVTGKDNYGS
ISLGNITDTMTFDVTVHNLSNKDKTLRYDTELLTDHVDPQKGRFTLTSHS
LKTYQGGEVTVPANGKVTVRVTMDVSQFTKELTKQMPNGYYLEGFVRFRD
SQDDQLNRVNIPFVGFKGQFENLAVAEESIYRLKSQGKTGFYFDESGPKD
DIYVGKHFTGLVTLGSETNVSTKTISDNGLHTLGTFKNADGKFILEKNAQ
GNPVLAISPNGDNNQDFAAFKGVFLRKYQGLKASVYHASDKEHKNPLWVS
PESFKGDKNFNSDIRFAKSTTLLGTAFSGKSLTGAELPDGHYHYVVSYYP
DVVGAKRQEMTFDMILDRQKPVLSQATFDPETNRFKPEPLKDRGLAGVRK
DSVFYLERKDNKPYTVTINDSYKYVSVEDNKTFVERQADGSFILPLDKAK
LGDFYYMVEDFAGNVAIAKLGDHLPQTLGKTPIKLKLTDGNYQTKETLKD
NLEMTQSDTGLVTNQAQLAVVHRNQPQSQLTKMNQDFFISPNEDGNKDFV
AFKGLKNNVYNDLTVNVYAKDDHQKQTPIWSSQAGASVSAIESTAWYGIT
ARGSKVMPGDYQYVVTYRDEHGKEHQKQYTISVNDKKPMITQGRFDTING
VDHFTPDKTKALDSSGIVREEVFYLAKKNGRKFDVTEGKDGITVSDNKVY
IPKNPDGSYTISKRDGVTLSDYYYLVEDRAGNVSFATLRDLKAVGKDKAV
VNFGLDLPVPEDKQIVNFTYLVRDADGKPIENLEYYNNSGNSLILPYGKY
TVELLTYDTNAAKLESDKIVSFTLSADNNFQQVTFKITMLATSQITAHFD
HLLPEGSRVSLKTAQDQLIPLEQSLYVPKAYGKTVQEGTYEVVVSLPKGY
RIEGNTKVNTLPNEVHELSLRLVKVGDASDSTGDHKVMSKNNSQALTASA
TPTKSTTSATAKALPSTGEKMGLKLRIVGLVLLGLTCVFSRKKSTKD
>SPy1896 ropA, transcription regulator-(trigger factor (prolyl isomerase))
MSTSFENKATNRGVITFTISQDKIKPALDKAFNKIKKDLNAPGFRKGHMP
RPVFNQKFGEEVLYEDALNIVLPEAYEAAVTELGLDVVAQPKIDVVSMEK
GKEWTLSAEVVTKPEVKLGDYKNLVVEVDASKEVSDEDVDAKIERERQNL
AELIIKDGEAAQGDTVVIDFVGSVDGVEFDGGKGDNFSLELGSGQFIPGF
EDQLVGAKAGDEVEVNVTFPESYQAEDLAGKAAKFMTTIHEVKTKEVPEL
DDELAKDIDEDVDTLEDLKVKYRKELEAAQETAYDDAVEGAAIELAVANA
EIVDLPEEMIHEEVNRSVNEFMGNMQRQGISPEMYFQLTGTTQEDLHNQY
SAEADKRVKTHLVIEAIAKAEGFEATDSEIEQEINDLATEYNMPADQVRS
LLSADMLKHDIAMKKAVEVITSTASVK
>SPy1172 satE, conserved hypothetical protein
MINGVSHYLAQTPTLTLFLICHVLSDYQLQSQQVADLKEKHLTYLGYHLI
GVSIPLICLTLIIPQAWLMSLLVMISHALIDWLKPKMANSLKWKREWIFL
LDQCLHIAISSFAGLRLAGVTLPNWLPISILMTVLFILLITKPTNIVFKL
FFIKYQPDQGEKMDTIIGAGATIGILERIVIGVCMIMGQFASIGLVFTAK
SIARYNKISESPAFAEYYLIGSLFSILSVFIAAWICFF
>SPy0236 sms, putative DNA repair protein
MAKKKATFICQECGYQSPKYLGRCPNCSAWSSFVEEVEVKEVKNARVSLA
GEKSRPVKLKDVDNISYHRTQTDMSEFNRVLGGGVVPGSLILIGGDPGIG
KSTLLLQVSTQLANKGTVLYVSGEESAEQIKLRSERLGDIDNEFYLYAET
NMQAIRTEIENIKPDFLIIDSIQTIMSPDITGVQGSVSQVREVTAELMQL
AKTNNIATFIVGHVTKEGTLAGPRMLEHMVDTVLYFEGERHHTFRILRAV
KNRFGSTNEIGIFEMQSGGLVEVLNPSQVFLEERLDGATGSAVVVTMEGS
RPILAEVQSLVTPTVFGNARRTTTGLDFNRVSLIMAVLEKRCGLLLQNQD
AYLKSAGGVKLDEPAIDLAVAVAIASSYKEKPTSPQEAFLGEIGLTGEIR
RVTRIEQRINEAAKLGFTKVYAPKNALQGIDIPQGIEVVGVTTVGQVLNA
VFS
>SPy1835 trx, putative thioredoxin
MALEVTDATFVEETKEGLVLIDFWATWCGPCRMQAPILEQLSQEIDEDEL
KILKMDVDENPETARQFGIMSIPTLMFKKDGEVVKQVAGVHTKDQLKAII
AELS