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# Mycobacterium tuberculosis H37Rv, H37Rv

>Rv1937 POSSIBLE OXYGENASE
MAVRQVTVGYSDGTHKTMPVRCDQTVLDAAEEHGVAIVNECQSGICGTCV
ATCTAGRYQMGRTEGLSDVERAARKILTCQTFVTSDCRIELQYPVDDNAA
LLVTGDGVVTAVELVSPSTAILRVDTSGMAGALRYRAGQFAQLQVPGTNV
WRNYSYAHPADGRGECEFIIRLLPDGVMSNYLRDRAQPGDHIALRCSKGS
FYLRPIVRPVILVAGGTGLSAILAMAQSLDADVAHPVYLLYGVERTEDLC
KLDELTELRRRVGRLEVHVVVARPDPDWDGRTGLVTDLLDERMLASGDAD
VYLCGPVAMVDAARTWLDHNGFHRVGLYYEKFVASGAARRRTPARLDYAG
VDIAEVCRRGRGTAVVIGGSIAGIAAAKMLSETFDRVIVLEKDGPHRRRE
GRPGAAQGWHLHHLLTAGQIELERIFPGIVDDMVREGAFKVDMAAQYRIR
LGGTWKKPGTSDIEIVCAGRPLLEWCVRRRLDDEPRIDFRYESEVADLAF
DRANNAIVGVAVDNGDADGGDGLQVVPAEFVVDASGKNTRVPEFLERLGV
GAPEAEQDIINCFYSTMQHRVPPERRWQDKVMVICYAYRPFEDTYAAQYY
TDSSRTILSTSLVAYNCYSPPRTAREFRAFADLMPSPVIGENIDGLEPAS
PIYNFRYPNMLRLRYEKKRNLPRALLAVGDAYTSADPVSGLGMSLALKEV
REMQALLAKYGAGHRDLPRRYYRAIAKMADTAWFVIREQNLRFDWMKDVD
KKRPFYFGVLTWYMDRVLELVHDDLDAYREFLAVVHLVKPPSALMRPRIA
SRVLGKWARTRLSGQKTLIARNYENHPIPAEPADQLVNA
>Rv1260 PROBABLE OXIDOREDUCTASE
MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAIDVRGPAL
DVLERMGLLAAAQEHKTRIRGASFVDRDGNELFRDTESTPTGGPVNSPDI
ELLRDDLVELLYGATQPSVEYLFDDSISTLQDDGDSVRVTFERAAAREFD
LVIGADGLHSNVRRLVFGPEEQFVKRLGTHAAIFTVPNFLELDYWQTWHY
GDSTMAGVYSARNNTEARAALAFMDTELRIDYRDTEAQFAELQRRMAEDG
WVRAQLLHYMRSAPDFYFDEMSQILMDRWSRGRVALVGDAGYCCSPLSGQ
GTSVALLGAYILAGELKAAGDDYQLGFANYHAEFHGFVERNQWLVSDNIP
GGAPIPQEEFERIVHSITIKDY
>Rv0958 POSSIBLE MAGNESIUM CHELATASE
MSPSNLPRTVGELRAAGHRERGVKQEIRENLLTALADGDNVWPGILGFDD
TVIPQVERALIAGHDFVLLGERGQGKTRLLRALAGLLDEWTPVIAGAELG
EHPYTPITPESIRRAAQLGDDLPVAWKHRSERYTEKLATPDTSVADLVGD
VDPIKVAEGRSLGDPETIAYGLIPRAHRGIVAVNELPDLAERIQVSMLNV
MEERDIQVRGYTLRLPLDVLVVASANPEDYTNRGRIITPIKDRFGAEIRT
HYPLELEAEMGVIVQEAHLSAQVSDYLMQVLARFARYLRESRSIDQRSGV
SARFAIAAAETVAAAARHRGAVLGETDPVARVVDLGTVIDVLRGKLEFES
GEEGREQAVLEHLLRRATADTASRVLGGIDVGSLVTAVEGGSAVTTGERV
SAKDVLAAVPGLPVVDRIARKLGAESEGERAAALELALEALYLAKRVDKV
CGEGQTVYG
>Rv0812 PROBABLE AMINO ACID AMINOTRANSFERASE
MVVTLDGEILQPGMPLLHADDLAAVRGDGVFETLLVRDGRACLVEAHLQR
LTQSARLMDLPEPDLPRWRRAVEVATQRWVASTADEGALRLIYSRGREGG
SAPTAYVMVSPVPARVIGARRDGVSAITLDRGLPADGGDAMPWLIASAKT
LSYAVNMAVLRHAARQGAGDVIFVSTDGYVLEGPRSTVVIATDGDQGGGN
PCLLTPPPWYPILRGTTQQALFEVARAKGYDCDYRALRVADLFDSQGIWL
VSSMTLAARVHTLDGRRLPRTPIAEVFAELVDAAIVSDR
>Rv1335 9.5 KDA CULTURE FILTRATE ANTIGEN CFP10A
MNVTVSIPTILRPHTGGQKSVSASGDTLGAVISDLEANYSGISERLMDPS
SPGKLHRFVNIYVNDEDVRFSGGLATAIADGDSVTILPAVAGG
>Rv0992c CONSERVED HYPOTHETICAL PROTEIN
MAMASKSALRDQLLAARRRVADDVRAAEARMLRGHLERMVTSDSTVCAYV
PVGGEPGSIEMLDVLLRRAGRVLLPVARTAGGDLPLPLRWGEYRAGGLAR
ARWGLLEPPEPWLPEAALAQASLVLVPALAVDRQGVRLGRGRGFYDRSLR
CRDPHARLVAVVRTVELVDVLPSEPHDVPMTHALTPERGLIALPCGE
>Rv2949c CONSERVED HYPOTHETICAL PROTEIN
MTECFLSDQEIRKLNRDLRILIAANGTLTRVLNIVADDEVIVQIVKQRIH
DVSPKLSEFEQLGQVGVGRVLQRYIILKGRNSEHLFVAAESLIAIDRLPA
AIITRLTQTNDPLGEVMAASHIETFKEEAKVWVGDLPGWLALHGYQNSRK
RAVARRYRVISGGQPIMVVTEHFLRSVFRDAPHEEPDRWQFSNAITLAR
>Rv0260c POSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN
MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDD
DELQNNTEALIADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSAR
IISRGPKATGALRAAGLREEWSPDSESSHEVLEYLLESGVSRTRIAVQLH
GAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLGGVFDHLVTGIARR
QFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTSRPL
IRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV
DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVL
RLRTALGDKNIVATVVKRGYRLAVDSRHDDV
>Rv3329 PROBABLE AMINOTRANSFERASE
MHFARHGAGIQHPVIVRGDGVTIFDDRGKSYLDALSGLFVVQVGYGRAEL
AEAAARQAGTLGYFPLWGYATPPAIELAERLARYAPGDLNRVFFTSGGTE
AVETAWKVAKQYFKLTGKPGKQKVISRSIAYHGTTQGALAITGLPLFKAP
FEPLTPGGFRVPNTNFYRAPLHTDLKEFGRWAADRIAEAIEFEGPDTVAA
VFLEPVQNAGGCIPAPPGYFERVREICDRYDVLLVSDEVICAFGRIGSMF
ACEDLGYVPDMITCAKGLTSGYSPLGAMIASDRLFEPFNDGETMFAHGYT
FGGHPVSAAVGLANLDIFEREGLSDHVKRNSPALRATLEKLYDLPIVGDI
RGEGYFFGIELVKDQATKQTFTDDERARLLGQVSAALFEAGLYCRTDDRG
DPVVQVAPPLISGQPEFDTIETILRSVLTDTGRKYLHL
>Rv3806c POSSIBLE CONSERVED INTEGRAL MEMBRANE PROTEIN
MSEDVVTQPPANLVAGVVKAIRPRQWVKNVLVLAAPLAALGGGVRYDYVE
VLSKVSMAFVVFSLAASAVYLVNDVRDVEADREHPTKRFRPIAAGVVPEW
LAYTVAVVLGVTSLAGAWMLTPNLALVMVVYLAMQLAYCFGLKHQAVVEI
CVVSSAYLIRAIAGGVATKIPLSKWFLLIMAFGSLFMVAGKRYAELHLAE
RTGAAIRKSLESYTSTYLRFVWTLSATAVVLCYGLWAFERDGYSGSWFAV
SMIPFTIAILRYAVDVDGGLAGEPEDIALRDRVLQLLALAWIATVGAAVA
FG
>Rv0756c HYPOTHETICAL PROTEIN
MNLGQTLVGIATWPARAGLAAADTGLNMAGAAVDMAKQALGDAGGASGST
SMANMLGIDDTIARANRLARLLDDDMPLGRAIAPNGPMDRMLRPGGVVDL
LTQPGGLLDRLTAEGGAMQRALQPGGLADQLLAEDGLIERVLSEDGLADR
LLAEGGLIDKITAKDGPLEQLADVADTLARLTPGMEALEPAIATLQDAVI
ALTMVVNPLSSIAERIPLPGRRPARRSSSRSVRSQRVVDSE
>Rv0385 PROBABLE MONOOXYGENASE
MGLEDRDALRVLQNAFKLDDPELVRRFYAHWFALDASVRDLFPPDMGAQR
AAFGQALHWVYGELVAQRAEEPVAFLAQLGRDHRKYGVLPTQYDTLRRAL
YTTLRDYLGHPSRGAWTDAVDEAAGQSLNLIIGVMSGAADADDAPAWWDG
TVVEHIRVSRDLAVARLQLDRPLHYYPGQYVNVHVPQCPRRWRYLSPAIP
ADPNGRIEFHVRVVPGGLVSNAIVGETRPGDRWRLSGPHGAFRVDRDGGD
VLMVAGSTGLAPLRALIIDLSRFAVNPRVHLFFGARYACELYDLPTLWQI
AAHNPWLSVSPVSEYNGDPAWAADYPDVSAPRGLHVRQTGRLPDVVSRYG
GWGDRQILICGGPAMVRATKAALIAKGAPPERIQHDPLSR
>Rv2606c Possible pyridoxine biosynthesis protein
MDPAGNPATGTARVKRGMAEMLKGGVIMDVVTPEQARIAEGAGAVAVMAL
ERVPADIRAQGGVSRMSDPDMIEGIIAAVTIPVMAKVRIGHFVEAQILQT
LGVDYIDESEVLTPADYAHHIDKWNFTVPFVCGATNLGEALRRISEGAAM
IRSKGEAGTGDVSNATTHMRAIGGEIRRLTSMSEDELFVAAKELQAPYEL
VAEVARAGKLPVTLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSGAPE
HRAAAIVKATTFFDDPDVLAKVSRGLGEAMVGINVDEIAVGHRLAQRGW
>Rv2850c POSSIBLE MAGNESIUM CHELATASE
MKPYPFSAIVGHDRLRLALLLCAVRPEIGGALIRGEKGTAKSTAVRGLAA
LLSVATGSTETGLVELPLGATEDRVVGSLDLQRVMRDGEHAFSPGLLARA
HGGVLYVDEVNLLHDHLVDILLDAAAMGRVHVERDGISHSHEARFVLIGT
MNPEEGELRPQLLDRFGLTVDVQASRDIDVRVQVIRRRMAYEADPDAFVA
RYADADAELAHRIAAARATVDDVVLGDNELRRIAALCAAFDVDGMRADLV
VARTAAAHAAWRGVRTVEEQDIRAAAELALPHRRRRDPFDDHGIDRDQLD
EALALASVDPEPEPDPPGGGQSANEPASQPNSRSKSTEPGAPSSMGDDPP
RPASPRLRSSPRPSAPPSKIFRTRALRVPGVGTGAPGRRSRARNASGSVV
AAAEVSDPDAHGLHLFATLLAAGERAFGAGPLRPWPDDVRRAIREGREGN
LVIFVVDASGSMAARDRMAAVSGATLSLLRDAYQRRDKVAVITFRQHEAT
LLLSPTSSAHIAGRRLARFSTGGKTPLAEGLLAARALIIREKVRDRARRP
LVVVLTDGRATAGPDPLGRSRTAAAGLVAEGAAAVVVDCETSYVRLGLAA
QLARQLGAPVVRLEQLHADYLVHAVRGVA
>Rv0573c CONSERVED HYPOTHETICAL PROTEIN
MAIRQHVGALFTDLYEVTMAQAYWAERMSGTAVFEIFFRKLPPGRSYIMA
AGLADVVEFLEAFRFDEQDLRYLRGLGQFSDEFLRWLAGVRFTGDVWAAP
EGTVIFPNEPAVQLIAPIIEAQLVETFVLNQIHLQSVLASKAARVVAAAR
GRPVVDFGARRAHGTDAACKVARTSYLAGAAGTSNLLAARQYGIPTFGTM
AHSFVQAFDSEVAAFEAFARLYPATMLLVDTYDTLRGVDHVIELAKRLGN
RFDVRAVRLDSGDLDELSKATRARLDTAGLEQVEIFASSGLDENRIAALL
AARCPIDGFGVGTQLVVAQDAPALDMAYKLVAYDGSGRTKFSSGKVIYPG
RKQVFRKLEHGVFCGDTLGEHGENLPGDPLLVPIMTNGRRIRQHAPTLDG
ARDWARQQIDALPPELRSLEDTGYSYPVAVSDRIVGELARLRHADTAEAH
PGSNVVGAKAKRP
>Rv1330c CONSERVED HYPOTHETICAL PROTEIN
MGPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVF
ARRLPTGRRYGVVAGTGRLLEALPQFRFDADACELLAQFLDPATVRYLRE
FRFRGDIDGYAEGELYFPGSPVLSVRGSFAECVLLETLVLSIFNHDTAIA
SAAARMVSAAGGRPLIEMGSRRTHERAAVAAARAAYIAGFAASSNLAAQR
RYGVPAHGTAAHAFTMLHAQHGGPTELAERAAFRAQVEALGPGTTLLVDT
YDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRIV
VSGDLDEFSIAALRGEPVDSYGVGTSLVTGSGAPTANMVYKLVEVDGVPV
QKRSSYKESPGGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTLP
LVRAGQPVADTSLAAARQLVASGLRSLPGDGLKLAPGEPAIPTRTIPA
>Rv1751 PROBABLE OXIDOREDUCTASE
MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
MRLLDELGLWERFAALPYSEVRTATLHSNGRAVTYIDFERLHQPYPYVAM
VPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLREGGKVTGVRYQGAEGPG
ELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPREGDAEFSFL
PRFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRERGIEEFRRDVSELLPE
ATASVAALASMDEVKHLNVKVNRLRRWHIDGLLCIGDAAHAMSPVAGVGI
NLAVQDAVAAATILAEPLREHRVSSRHLAAVRRRRAFPTAVTQAVQRVLH
RRLLGPLLQGRDPTPPAALLGLVERLPWLSAVPAYFVGVGVRPEHAPAFA
RRGPGNRKGP
>Rv3369 CONSERVED HYPOTHETICAL PROTEIN
MWAGYRWAMSVELTQEVSARLTSDLYGWLTTVARSGQPVPRLVWFYFDGT
DLTVYSMPQAAKVAHITAHPQVSLNLDSDGNGAGIIVVGGTAAVVATDVD
CRDDAPYWAKYREDAAKFGLTEAIAAYSTRLKITPTRVWTTPTG
>Rv2604c CONSERVED HYPOTHETICAL PROTEIN
MSVPRVGVLALQGDTREHLAALRECGAEPMTVRRRDELDAVDALVIPGGE
STTMSHLLLDLDLLGPLRARLADGLPAYGSCAGMILLASEILDAGAAGRQ
ALPLRAMNMTVRRNAFGSQVDSFEGDIEFAGLDDPVRAVFIRAPWVERVG
DGVQVLARAAGHIVAVRQGAVLATAFHPEMTGDRRIHQLFVDIVTSAA
>Rv1159A HYPOTHETICAL PROTEIN
MAVLTDEQVDAALHDLNGWQRAGGVLRRSIKFPTFMAGIDAVRRVAERAE
EVNHHPDIDIRWRTVTFALVTHAVGGITENDIAMAHDIDAMFGA
>Rv0470A HYPOTHETICAL PROTEIN
MGAGGWEVVLASLPYGLLCTTVLMGKHIDKIGYDEPLGIRTLPVLLGETC
ARTVTLAMMVGFYLLIAVNVMLAAMPWPRCWSPGRCPGWRKCGPISCDGG
PSSRHRRFRCGRCGMPRWPGCTCVRPVRCWLWAWRSVPGGAPGDFR
>Rv0854 CONSERVED HYPOTHETICAL PROTEIN
MAIKESRDIVIEASPEEILDVIADFEAMTEWSPAHQSVEILETGDDGRPS
KVKMKVKTAGITDEQVVAYSWTDRSVRWTLVSSTQQRSQDGKYELTPKGD
NTLVQFEITVDPQVPLPGFVLKRAIKGTIDTATEALRSQVLKVKKGQ
>Rv2573 CONSERVED HYPOTHETICAL PROTEIN
MVPGPVHTSPREVAGPVDVLILAVKATQNDAARPWLTRLCDERTVVAVLQ
NGVEQVEQVQPHCPSSAVVPAIVWCSAETQPQGWVRLRGEAALVVPTGPA
AEQFAGLLRGAGATVDCDPDFTTAAWRKLLVNALAGFMVLSGRRSAMFRR
DDVAALSRRYVAECLAVARAEGARLDDDVVDEVVRLVRSAPQDMGTSMLA
DRAAHRPLEWDLRNGVIVRKARAHGLATPISDVLVPLLAAASDGPG
>Rv0575c POSSIBLE OXIDOREDUCTASE
MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMIDFWGVGYQ
VAKRMGITDQIAAAGYHMEHVRSVGPTGKVKADLGVDVFRRMVGDDFTSL
PRGDLAAAIYTTIEDQVETIFDDSIATIDEHRDGVRLTFERTAPRDFDLV
IGADGLHSNVRRLVFGPERDFEHYLGCKVAACVVDGYRPRDERSYVLYNT
VDRQLARFALRGDRTMFLFVFRAEHDNPGVAPKDELRDQFGDVGWESRDI
LAALDDVEDLYFDVVSQIRMDRWSRGRVLLIGDAAGCISLLGGEGTGLAI
TEAYVLAGELARAGGDHRRAFDAYEKRLRPFIEGKQASAAKFIWFFATRT
RFGLWFRNVAMRTMNFGPLATLFAGSVRDDFELPDYTW
>Rv1568 bioA, PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA
MAAATGGLTPEQIIAVDGAHLWHPYSSIGREAVSPVVAVAAHGAWLTLIR
DGQPIEVLDAMSSWWTAIHGHGHPALDQALTTQLRVMNHVMFGGLTHEPA
ARLAKLLVDITPAGLDTVFFSDSGSVSVEVAAKMALQYWRGRGLPGKRRL
MTWRGGYHGDTFLAMSICDPHGGMHSLWTDVLAAQVFAPQVPRDYDPAYS
AAFEAQLAQHAGELAAVVVEPVVQGAGGMRFHDPRYLHDLRDICRRYEVL
LIFDEIATGFGRTGALFAADHAGVSPDIMCVGKALTGGYLSLAATLCTAD
VAHTISAGAAGALMHGPTFMANPLACAVSVASVELLLGQDWRTRITELAA
GLTAGLDTARALPAVTDVRVCGAIGVIECDRPVDLAVATPAALDRGVWLR
PFRNLVYAMPPYICTPAEITQITSAMVEVARLVGSLP
>Rv1589 bioB, PROBABLE BIOTIN SYNTHETASE BIOB
MTQAATRPTNDAGQDGGNNSDILVVARQQVLQRGEGLNQDQVLAVLQLPD
DRLEELLALAHEVRMRWCGPEVEVEGIISLKTGGCPEDCHFCSQSGLFAS
PVRSAWLDIPSLVEAAKQTAKSGATEFCIVAAVRGPDERLMAQVAAGIEA
IRNEVEINIACSLGMLTAEQVDQLAARGVHRYNHNLETARSFFANVVTTH
TWEERWQTLSMVRDAGMEVCCGGILGMGETLQQRAEFAAELAELGPDEVP
LNFLNPRPGTPFADLEVMPVGDALKAVAAFRLALPRTMLRFAGGREITLG
DLGAKRGILGGINAVIVGNYLTTLGRPAEADLELLDELQMPLKALNASL
>Rv1570 bioD, Probable dethiobiotin synthetase bioD
MTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDL
AEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDR
PGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTK
LTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGA
ASLDAGDFAAMSAAAFDRNWVAGLVG
>Rv1569 bioF1, PROBABLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF1 (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE) (7-KAP SYNTHETA
MKAATQARIDDSPLAWLDAVQRQRHEAGLRRCLRPRPAVATELDLASNDY
LGLSRHPAVIDGGVQALRIWGAGATGSRLVTGDTKLHQQFEAELAEFVGA
AAGLLFSSGYTANLGAVVGLSGPGSLLVSDARSHASLVDACRLSRARVVV
TPHRDVDAVDAALRSRDEQRAVVVTDSVFSADGSLAPVRELLEVCRRHGA
LLLVDEAHGLGVRGGGRGLLYELGLAGAPDVVMTTTLSKALGSQGGVVLG
PTPVRAHLIDAARPFIFDTGLAPAAVGAARAALRVLQAEPWRPQAVLNHA
GELARMCGVAAVPDSAMVSVILGEPESAVAAAAACLDAGVKVGCFRPPTV
PAGTSRLRLTARASLNAGELELARRVLTDVLAVARR
>Rv0032 bioF2, POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF2 (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE) (7-KAP SYNTHETA
MPTGLGYDFLRPVEDSGINDLKHYYFMADLADGQPLGRANLYSVCFDLAT
TDRKLTPAWRTTIKRWFPGFMTFRFLECGLLTMVSNPLALRSDTDLERVL
PVLAGQMDQLAHDDGSDFLMIRDVDPEHYQRYLDILRPLGFRPALGFSRV
DTTISWSSVEEALGCLSHKRRLPLKTSLEFRERFGIEVEELDEYAEHAPV
LARLWRNVKTEAKDYQREDLNPEFFAACSRHLHGRSRLWLFRYQGTPIAF
FLNVWGADENYILLEWGIDRDFEHYRKANLYRAALMLSLKDAISRDKRRM
EMGITNYFTKLRIPGARVIPTIYFLRHSTDPVHTATLARMMMHNIQRPTL
PDDMSEEFCRWEERIRLDQDGLPEHDIFRKIDRQHKYTGLKLGGVYGFYP
RFTGPQRSTVKAAELGEIVLLGTNSYLGLATHPEVVEASAEATRRYGTGC
SGSPLLNGTLDLHVSLEQELACFLGKPAAVLCSTGYQSNLAAISALCESG
DMIIQDALNHRSLFDAARLSGADFTLYRHNDMDHLARVLRRTEGRRRIIV
VDAVFSMEGTVADLATIAELADRHGCRVYVDESHALGVLGPDGRGASAAL
GVLARMDVVMGTFSKSFASVGGFIAGDRPVVDYIRHNGSGHVFSASLPPA
AAAATHAALRVSRREPDRRARVLAAAEYMATGLARQGYQAEYHGTAIVPV
ILGNPTVAHAGYLRLMRSGVYVNPVAPPAVPEERSGFRTSYLADHRQSDL
DRALHVFAGLAEDLTPQGAAL
>Rv3279c birA, POSSIBLE BIFUNCTIONAL PROTEIN BIRA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGASE)
MTDRDRLRPPLDERSLRDQLIGAGSGWRQLDVVAQTGSTNADLLARAASG
ADIDGVVLIAEHQTAGRGRHGRGWAATARAQIILSVGVRVVDVPVQAWGW
LSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLARGGKLAGILAEVAQPF
VVLGVGLNVTQAPEEVDPDATSLLDLGVAAPDRNRIASRLLRELEARIIQ
WRNANPQLAADYRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCLDV
GGRTVVVSAGDVVHLR
>Rv1092c coaA, Probable pantothenate kinase coaA (Pantothenic acid kinase)
MSRLSEPSPYVEFDRRQWRALRMSTPLALTEEELVGLRGLGEQIDLLEVE
EVYLPLARLIHLQVAARQRLFAATAEFLGEPQQNPDRPVPFIIGVAGSVA
VGKSTTARVLQALLARWDHHPRVDLVTTDGFLYPNAELQRRNLMHRKGFP
ESYNRRALMRFVTSVKSGSDYACAPVYSHLHYDIIPGAEQVVRHPDILIL
EGLNVLQTGPTLMVSDLFDFSLYVDARIEDIEQWYVSRFLAMRTTAFADP
ESHFHHYAAFSDSQAVVAAREIWRTINRPNLVENILPTRPRATLVLRKDA
DHSINRLRLRKL
>Rv2848c cobB, PROBABLE COBYRINIC ACID A,C-DIAMIDE SYNTHASE COBB
MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYH
ALAAGRPGRNLDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGP
AGGAPAAGSTAHVAALLGAPVILVVDARGQSHSVAALLHGFSTFDTATRI
AGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELELPTRYLGLVTA
VEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPVIAVGNTA
RQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV
LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGH
PMCGVVAGSARFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTF
ADSYQPAWVYQGQDVDDVRDGAVHSGVHASYLHTHPAATPGAVARFVAHA
ACNTPRA
>Rv2236c cobD, Probable cobalamin biosynthesis transmembrane protein CobD
MFASTWQTRAVGVLIGCLLDVVFGDPKRGHPVALFGRAAAKLEQITYRDG
RVAGAVHVGLLVGAVGLLGAALQRLPGRSWPVAATATATWAALGGTSLAR
TGRQISDLLERDDVEAARRLLPSLCGRDPAQLGGPGLTRAALESVAENTA
DAQVVPLLWAASSGVPAVLGYRAINTLDSMIGYRSPRYLRFGWAAARLDD
WANYVGARATAVLVVICAPVVGGSPRGAVRAWRRDAARHPSPNAGVVEAA
FAGALDVRLGGPTRYHHELQIRPTLGDGRSPKVADLRRAVVLSRVVQAGA
AVLAVMLVYRRRP
>Rv2065 cobH, Probable precorrin-8X methylmutase CobH (aka precorrin isomerase)
MLDYLRDAAEIYRRSFAVIRAEADLARFPADVARVVVRLIHTCGQVDVAE
HVAYTDDVVARAGAALAAGAPVLCDSSMVAAGITTSRLPADNQIVSLVAD
PRATELAARRQTTRSAAGVELCAERLPGAVLAIGNAPTALFRLLELVDEG
APPPAAVLGGPVGFVGSAQAKEELIERPRGMSYLVVRGRRGGSAMAAAAV
NAIASDRE
>Rv2066 cobI, Probable bifunctional protein, CobI-CobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase
MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIA
EPYLRPGQLEEHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAG
RNVALLAEGDPLFYSSYMHLHTRLTRRFNAVIVPGVTSVSAASAAVATPL
VAGDQVLSVLPGTLPVGELTRRLADADAAVVVKLGRSYHNVREALSASGL
LGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGRRRALLTGTVA
VVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT
DEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRV
IPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLV
LAIYNPASVTRTWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVR
VVKLADLNPAEIDMRCLLIVGSSQTRWYSVDSQDRVFTPRRYPEAGRATA
TKSSRHSD
>Rv2070c cobK, Probable precorrin-6X reductase CobK
MTRVLLLGGTAEGRALAKELHPHVEIVSSLAGRVPNPALPIGPVRIGGFG
GVEGLRGWLREERIDAVVDATHPFAVTITAHAAQVCGELGLPYLVLARPP
WDPGTAIIAVSDIEAADVVAEQGYSRVFLTTGRSGIAAFANSDAWFLIRV
VTAPDGTALPRRHKLVLSRGPYGYHDEFALLREQRIDALVTKNSGGKMTR
AKLDAAAALGISVVMIARPLLPAGVAAVDSVHRAAMWVAGLPSR
>Rv2072c cobL, Probable precorrin-6y methyltransferase CobL
MIIVVGIGADGMTGLSEHSRSELRRATVIYGSKRQLALLDDTVTAERWEW
PTPMLPAVQGLSPDGADLHVVASGDPLLHGIGSTLIRLFGHDNVTVLPHV
SAVTLACARMGWNVYDTEVISLVTAQPHTAVRRGGRAIVLSGDRSTPQAL
AVLLTEHGRGDSKFSVLEQLGGPAERRRDGTARAWACDPPLDVDELNVIA
VRYLLDERTSWAPDEAFAHDGQITKHPIRVLTLAALAPRPGQRLWDVGAG
SGAIAVQWCRSWPGCTAVAFERDERRRRNIGFNAAAFGVSVDVRGDAPDA
FDDAARPSVIFLGGGVTQPGLLEACLDSLPAGGNLVANAVTVESEAALAH
AYSRLGGELRRFQHYLGEPLGGFTGWRPQLPVTQWSVTKR
>Rv2071c cobM, Probable precorrin-4 C11-methyltransferase CobM
MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGAT
IVDTGPLTLEQIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDAL
GIGYEIVPGVPAFAAAAAALKRELTVPGVAQTVTLTRVATLSTPIPPGED
LAALARSRATLVLHLAAAQIDAIVPRLLDGGYRPETPVAVVAFASWPQQR
TLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYLYSVARHGRYA
Q
>Rv2062c cobN, Probable cobalamin biosynthesis protein cobN
MPEPTVLLLSTSDTDLISARSSGKNYRWANPSRLSDLELTDLLAEASIVV
IRILGGYRAWQSGIDTVIAGGVPAVLVSGEQAADAELTDRSTVAAGTALQ
AHIYLAHGGVDNLRELHAFLCDTVLMTGFGFTPPVATPTWGVLERPDAGK
TGPTIAVLYYRAQHLAGNTGYVEALCRAIEDAGGRPLPLYCASLRTAEPR
LLERLGGADAMVVTVLAAGGVKPAAASAGGDDDSWNVEHLAALDIPILQG
LCLTSPRDQWCANDDGLSPLDVASQVAVPEFDGRIITVPFSFKEIDDDGL
ISYVADPERCARVAGLAVRHARLRQVAPADKRVALVFSAYPTKHARIGNA
VGLDTPASAVALLQAMRQRGYRVGDLPGVESNDGDALIHALIECGGHDPD
WLTEGQLAGNPIRVSAKEYRDWFATLPAELTDVVTAYWGPPPGELFVDRS
HDPDGEIVIAALRAGNLVLMVQPPRGFGENPVAIYHDPDLPPSHHYLAAY
RWLDTGFSNGFGAHAVVHLGKHGNLEWLPGKTLGMSASCGPDAALGDLPL
IYPFLVNDPGEGTQAKRRAHAVLVDHLIPPMARAETYGDIARLEQLLDEH
ASVAALDPGKLPAIRQQIWTLIRAAKMDHDLGLTERPEEDSFDDMLLHVD
GWLCEIKDVQIRDGLHILGQNPTGEQELDLVLAILRARQLFGGAHAIPGL
RQALGLAEDGTDERATVDQTEAKARELVAALQATGWDPSAADRLTGNADA
AAVLRFAATEVIPRLAGTATEIEQVLRALDGRFIPAGPSGSPLRGLVNVL
PTGRNFYSVDPKAVPSRLAWEAGVALADSLLARYRDEHGRWPRSVGLSVW
GTSAMRTAGDDIAEVLALLGVRPVWDDASRRVIDLAPMQPAELGRPRIDV
TVRISGFFRDAFPHVVTMLDDAVRLVADLDEAAEDNYVRAHAQADLAHHG
DQRRATTRIFGSKPGTYGAGLLQLIDSRSWRDDADLAQVYTAWGGFAYGR
DLDGREAIDDMNRQYRRIAVAAKNTDTREHDIADSDDYFQYHGGMVATVR
ALTGQAPAAYIGDNTRPDAIRTRTLSEETTRVFRARVVNPRWMAAMRRHG
YKGAFEMAATVDYLFGYDATAGVMADWMYEQLTQRYVLDAQNRTFMTESN
PWALHGMAERLLEAAGRGLWAQPAPETLDGLRQVLLETEGDLEA
>Rv2849c cobO, PROBABLE COB(I)ALAMIN ADENOSYLTRANSFERASE COBO (CORRINOID ADENOSYLTRANSFERASE) (CORRINOID ADOTRANSFERASE ACTIVITY)
MPQGNPLAVPNDGLTTRARRNMPILAVHTGEGKGKSTAAFGMALRAWNAG
LDIAVFQFVKSAKWKVGEEAAFRQLGRLHDQHGIGGAVEWHKMGAGWSWT
RTSRKAGTDVDRAAAAADGWAEIALRLATQRHDFYLLDEFTYPLKWGWLD
VDEVVDVLRARPGHQHVVITGRDAPQRLVAAADLVTEMTKVKHPMDAGRK
GQKGIEW
>Rv0255c cobQ1, PROBABLE COBYRIC ACID SYNTHASE COBQ1
MSGLLVAGTTSDAGKSAVTAGLCRALARRGVRVAPFKAQNMSNNSMVCRG
PDGTGVEIGRAQWVQALAARTTPEAAMNPVLLKPASDHRSHVVLMGKPWG
EVASSSWCAGRRALAEAACRAFDALAARYDVVVAEGAGSPAEINLRAGDY
VNMGLARHAGLPTIVVGDIDRGGVFAAFLGTVALLAAEDQALVAGFVVNK
FRGDSDLLAPGLRDLERVTGRRVYGTLPWHPDLWLDSEDALDLQGRRAAG
TGARRVAVVRLPRISNFTDVDALGLEPDLDVVFASDPRALDDADLIVLPG
TRATIADLAWLRARDLDRALLVHVAAGKPLLGICGGFQMLGRVIRDPYGI
EGPGGQVTEVEGLGLLDVETAFSPHKVLRLPRGEGLGVPASGYEIHHGRI
TRGDTAEEFLGGARDGPVFGTMWHGSLEGDALREAFLRETLGLAPSGSCF
LAARERRLDLLGDLVERHLDVDALLNLARHGCPPTLPFLAPGAP
>Rv2208 cobS, Probable cobalamin 5'-phosphate synthase CobS
MMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWA
GAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALA
VMRDGSTGPFGVAAVVLVIALQGLAFATLTTVGIAGITLAVLSGRVTAVL
VCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVSVPAGPRPWQGPI
AVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSAVTLAGLARL
>Rv2207 cobT, Probablenicotinate-nucleotide- dimethylbenzimidazol phosphoribosyltransferase CobT
MIGFAPVSTPDAAAEAAARARQDSLTKPRGALGSLEDLSVWVASCQQRCP
PRQFERARVVVFAGDHGVARSGVSAYPPEVTAQMVANIDAGGAAINALAD
VAGATVRVADLAVDADPLSERIGAHKVRRGSGNIATEDALTNDETAAAIT
AGQQIADEEVDAGADLLIAGDMGIGNTTAAAVLVAALTDAEPVAVVGFGT
GIDDAGWARKTAAVRDALFRVRPVLPDPVGLLRCAGGADLAAIAGFCAQA
AVRRTPLLLDGVAVTAAALVAERLAPGAHRWWQAGHRSSEPGHGLALAAL
GLDPIVDLHMRLGEGTGAAVALMVLRAAVAALSSMATFTEAGVSTRSVDG
VDRTAPPAVSP
>Rv0254c cobU, PROBABLE BIFUNCTIONAL COBALAMIN BIOSYNTHESIS PROTEIN COBU: COBINAMIDE KINASE + COBINAMIDE PHOSPHATE GUANYLYLTRANSFERASE
MRILVTGGVRSGKSTHAEALLGDAADVVYVAPGRPAAGSDPDWDARVALH
RARRPPTWLTVETADVATALSEARSPVLVDCLGTWLTAIMDGEALWSAAT
ADVYAVLEARLDGLCAALTGLPTAIVVTNEVGLGVVPSHSSGVLFRDLLG
TINRRVAAVCDEVHLVIAGRVLKL
>Rv1285 cysD, PROBABLE SULFATE ADENYLYLTRANSFERASE SUBUNIT 2 CYSD
MAITINMVNPTGFIRYEDVEQEAMTSDVTVGPAPGQYQLSHLRLLEAEAI
HVIREVAAEFERPVLLFSGGKDSIVMLHLALKAFRPGRLPFPVMHVDTGH
NFDEVIATRDELVAAAGVRLVVASVQDDIDAGRVVETIPSRNPIQTVTLL
RAIRENQFDAAFGGARRDEEKARAKERVFSFRDEFGQWDPKAQRPELWNL
YNGRHHKGEHIRVFPLSNWTEFDIWSYIGAEQVRLPSIYFAHRRKVFQRD
GMLLAVHRHMQPRADEPVFEATVRFRTVGDVTCTGCVESSASTVAEVIAE
TAVARLTERGATRADDRISEAGMEDRKRQGYF
>Rv2847c cysG, POSSIBLE MULTIFUNCTIONAL ENZYME SIROHEME SYNTHASE CYSG: UROPORPHYRIN-III C-METHYLTRANSFERASE (UROGEN III METHYLASE) (SUMT) (UROPORPHYRINOGEN III METHY
MTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPA
VEAMDQITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCV
RADIAVEGTAVTPASFSYAGLSVGVLAGGEHRRSAAIRSAIREALQQGVI
TAQSSDVLSGGVALVGGGPGDPELITVRGRRLLAQADVVVADRLAPPELL
AELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFVVRLKGGDPFV
FARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVV
SGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADT
PVLVVQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVR
GLNNS
>Rv2392 cysH, PROBABLE 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE REDUCTASE CYSH (PAPS REDUCTASE, THIOREDOXIN DEP.) (PADOPS REDUCTASE) (3'-PHOSPHOADENYLYLSULFATE REDUCTA
MSGETTRLTEPQLRELAARGAAELDGATATDMLRWTDETFGDIGGAGGGV
SGHRGWTTCNYVVASNMADAVLVDLAAKVRPGVPVIFLDTGYHFVETIGT
RDAIESVYDVRVLNVTPEHTVAEQDELLGKDLFARNPHECCRLRKVVPLG
KTLRGYSAWVTGLRRVDAPTRANAPLVSFDETFKLVKVNPLAAWTDQDVQ
EYIADNDVLVNPLVREGYPSIGCAPCTAKPAEGADPRSGRWQGLAKTECG
LHAS
>Rv1391 dfp, PROBABLE DNA/PANTOTHENATE METABOLISM FLAVOPROTEIN HOMOLOG DFP
MVDHKRIPKQVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTESALRFV
GAATFEALSGEPVCTDVFADVPAVPHVHLGQQADLVVVAPATADLLARAA
AGRADDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGAVVL
EPATGRLTGADSGAGRLPEAEEITTLAQLLLERHDALPYDLAGRKLLVTA
GGTREPIDPVRFIGNRSSGKQGYAVARVAAQRGADVTLIAGHTAGLVDPA
GVEVVHVSSAQQLADAVSKHAPTADVLVMAAAVADFRPAQVATAKIKKGV
EGPPTIELLRNDDVLAGVVRARAHGQLPNMRAIVGFAAETGDANGDVLFH
ARAKLRRKGCDLLVVNAVGEGRAFEVDSNDGWLLASDGTESALQHGSKTL
MASRIVDAIVTFLAGCSS
>Rv2763c dfrA, DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)
MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSL
PAKVRPLPGRRNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVY
ALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLR
YRLYSYHRS
>Rv2682c dxs1, PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS1 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS)
MLQQIRGPADLQHLSQAQLRELAAEIREFLIHKVAATGGHLGPNLGVVEL
TLALHRVFDSPHDPIIFDTGHQAYVHKMLTGRSQDFATLRKKGGLSGYPS
RAESEHDWVESSHASAALSYADGLAKAFELTGHRNRHVVAVVGDGALTGG
MCWEALNNIAASRRPVIIVVNDNGRSYAPTIGGVADHLATLRLQPAYEQA
LETGRDLVRAVPLVGGLWFRFLHSVKAGIKDSLSPQLLFTDLGLKYVGPV
DGHDERAVEVALRSARRFGAPVIVHVVTRKGMGYPPAEADQAEQMHSTVP
IDPATGQATKVAGPGWTATFSDALIGYAQKRRDIVAITAAMPGPTGLTAF
GQRFPDRLFDVGIAEQHAMTSAAGLAMGGLHPVVAIYSTFLNRAFDQIMM
DVALHKLPVTMVLDRAGITGSDGASHNGMWDLSMLGIVPGIRVAAPRDAT
RLREELGEALDVDDGPTALRFPKGDVGEDISALERRGGVDVLAAPADGLN
HDVLLVAIGAFAPMALAVAKRLHNQGIGVTVIDPRWVLPVSDGVRELAVQ
HKLLVTLEDNGVNGGAGSAVSAALRRAEIDVPCRDVGLPQEFYEHASRSE
VLADLGLTDQDVARRITGWVAALGTGVCASDAIPEHLD
>Rv3379c dxs2, PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS2 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS)
MFDTGHQTYPHKLLTGRGKDFATLRQADGLSGYPNRHESPHDWVENSHAS
VSLAWVDGIAKALALQGQCDRRVIAVIGDGALTGGVAWEGLNNLGAATRP
VIVVLNDNGRSYDPTAGALAAHLEELRVGTPRGPNLFENMGFTYIGPVDG
HNIPDTCAVLRKAAAAARPVVVHAVTSKGRGYPPAEADERDHMHACGVVD
IATGLASTPSQRSWTDVFEDEIARIADDRSDVVGLTAAMRLPTGLGALSR
RYPHRVFDSGIAEQHLLASAAGLAAAGTHPVVAVYSTFLHRAFDQLLFDI
GLHRLPVTLVLDRAGVTGPDGPSHHGLWDLALLACVPGFQIACPRDAPRL
RQQLRTAIATAAPTAVRFPKGAPGEPITAEHTIGGLDVLHTPPPHWRPDV
LLVAVGAMSRPCMDAARCLSEEQIGVTVVDPQWVWPISPALTELAGRHRI
TVCVEDAIADVGIGAHLSHHIGRTHPRTRTYTLGLPPAYIPHASRDHILS
SHGLTGPAIRIRCKSLLNALHEVPGPEDHPDSGDSY
>Rv3215 entC, PROBABLE ISOCHORISMATE SYNTHASE ENTC (ISOCHORISMATE HYDROXYMUTASE) (ENTEROCHELIN BIOSYNTHESIS)
MSAHVATLHPEPPFALCGPRGTLIARGVRTRYCDVRAAQAALRSGTAPIL
LGALPFDVSRPAALMVPDGVLRARKLPDWPTGPLPKVRVAAALPPPADYL
TRIGRARDLLAAFDGPLHKVVLARAVQLTADAPLDARVLLRRLVVADPTA
YGYLVDLTSAGNDDTGAALVGASPELLVARSGNRVMCKPFAGSAPRAADP
KLDAANAAALASSAKNRHEHQLVVDTMRVALEPLCEDLTIPAQPQLNRTA
AVWHLCTAITGRLRNISTTAIDLALALHPTPAVGGVPTKAATELIAELEG
DRGFYAGAVGWCDGRGDGHWVVSIRCAQLSADRRAALAHAGGGIVAESDP
DDELEETTTKFATILTALGVEQ
>Rv1173 fbiC, PROBABLE F420 BIOSYNTHESIS PROTEIN FBIC
MPQPVGRKSTALPSPVVPPQANASALRRVLRRARDGVTLNVDEAAIAMTA
RGDELADLCASAARVRDAGLVSAGRHGPSGRLAISYSRKVFIPVTRLCRD
NCHYCTFVTVPGKLRAQGSSTYMEPDEILDVARRGAEFGCKEALFTLGDR
PEARWRQAREWLGERGYDSTLSYVRAMAIRVLEQTGLLPHLNPGVMSWSE
MSRLKPVAPSMGMMLETTSRRLFETKGLAHYGSPDKDPAVRLRVLTDAGR
LSIPFTTGLLVGIGETLSERADTLHAIRKSHKEFGHIQEVIVQNFRAKEH
TAMAAFPDAGIEDYLATVAVARLVLGPGMRIQAPPNLVSGDECRALVGAG
VDDWGGVSPLTPDHVNPERPWPALDELAAVTAEAGYDMVQRLTAQPKYVQ
AGAAWIDPRVRGHVVALADPATGLARDVNPVGMPWQEPDDVASWGRVDLG
AAIDTQGRNTAVRSDLASAFGDWESIREQVHELAVRAPERIDTDVLAALR
SAERAPAGCTDGEYLALATADGPALEAVAALADSLRRDVVGDEVTFVVNR
NINFTNICYTGCRFCAFAQRKGDADAYSLSVGEVADRAWEAHVAGATEVC
MQGGIDPELPVTGYADLVRAVKARVPSMHVHAFSPMEIANGVTKSGLSIR
EWLIGLREAGLDTIPGTAAEILDDEVRWVLTKGKLPTSLWIEIVTTAHEV
GLRSSSTMMYGHVDSPRHWVAHLNVLRDIQDRTGGFTEFVPLPFVHQNSP
LYLAGAARPGPSHRDNRAVHALARIMLHGRISHIQTSWVKLGVRRTQVML
EGGANDLGGTLMEETISRMAGSEHGSAKTVAELVAIAEGIGRPARQRTTT
YALLAA
>Rv3607c folB, PROBABLE DIHYDRONEOPTERIN ALDOLASE FOLB (DHNA)
MADRIELRGLTVHGRHGVYDHERVAGQRFVIDVTVWIDLAEAANSDDLAD
TYDYVRLASRAAEIVAGPPRKLIETVGAEIADHVMDDQRVHAVEVAVHKP
QAPIPQTFDDVAVVIRRSRRGGRGWVVPAGGAV
>Rv2447c folC, PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS)
MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRI
SALMDLLGSPQRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPH
LQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQASAGKGGPAMS
KFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISID
HVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEVLLAESV
RADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAH
NAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFI
DAAHNPAGASALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDS
VVVTHNGSPRALDVEALALAAGERFGPDRVRTAENLRDAIDVATSLVDDA
AADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ
>Rv3356c folD, PROBABLE BIFUNCTIONAL PROTEIN FOLD: METHYLENETETRAHYDROFOLATE DEHYDROGENASE + METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE
MGAIMLDGKATRDEIFGDLKQRVAALDAAGRTPGLGTILVGDDPGSQAYV
RGKHADCAKVGITSIRRDLPADISTATLNETIDELNANPDCTGYIVQLPL
PKHLDENAALERVDPAKDADGLHPTNLGRLVLGTPAPLPCTPRGIVHLLR
RYDISIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLPAL
TRQADIVVAAVGVAHLLTADMVRPGAAVIDVGVSRTDDGLVGDVHPDVWE
LAGHVSPNPGGVGPLTRAFLLTNVVELAERR
>Rv3609c folE, GTP CYCLOHYDROLASE I FOLE (GTP-CH-I)
MSQLDSRSASARIRVFDQQRAEAAVRELLYAIGEDPDRDGLVATPSRVAR
SYREMFAGLYTDPDSVLNTMFDEDHDELVLVKEIPMYSTCEHHLVAFHGV
AHVGYIPGDDGRVTGLSKIARLVDLYAKRPQVQERLTSQIADALMKKLDP
RGVIVVIEAEHLCMAMRGVRKPGSVTTTSAVRGLFKTNAASRAEALDLIL
RK
>Rv3606c folK, 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDI NE PYROPHOSPHOKINASE FOLK (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE) (HPPK) (6-HYDROXYMETHY
MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQF
LNAVLIADDPTCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQ
TSATEALVEVTARENHLTLPHPLAHLRAFVLIPWIAVDPTAQLTVAGCPR
PVTRLLAELEPADRDSVRLFRPSFDLNSRHPVSRAPES
>Rv3608c folP1, DIHYDROPTEROATE SYNTHASE 1 FOLP (DHPS 1) (DIHYDROPTEROATE PYROPHOSPHORYLASE 1) (DIHYDROPTEROATE DIPHOSPHORYLASE 1)
MSPAPVQVMGVLNVTDDSFSDGGCYLDLDDAVKHGLAMAAAGAGIVDVGG
ESSRPGATRVDPAVETSRVIPVVKELAAQGITVSIDTMRADVARAALQNG
AQMVNDVSGGRADPAMGPLLAEADVPWVLMHWRAVSADTPHVPVRYGNVV
AEVRADLLASVADAVAAGVDPARLVLDPGLGFAKTAQHNWAILHALPELV
ATGIPVLVGASRKRFLGALLAGPDGVMRPTDGRDTATAVISALAALHGAW
GVRVHDVRASVDAIKVVEAWMGAERIERDG
>Rv1207 folP2, PROBABLE DIHYDROPTEROATE SYNTHASE 2 FOLP2 (DHPS 2) (Dihydropteroate pyrophosphorylase 2)
MRSTPPASAGRSTPPALAGHSTPPALAGHSTLCGRPVAGDRALIMAIVNR
TPDSFYDKGATFSDAAARDAVHRAVADGADVIDVGGVKAGPGERVDVDTE
ITRLVPFIEWLRGAYPDQLISVDTWRAQVAKAACAAGADLINDTWGGVDP
AMPEVAAEFGAGLVCAHTGGALPRTRPFRVSYGTTTRGVVDAVISQVTAA
AERAVAAGVAREKVLIDPAHDFGKNTFHGLLLLRHVADLVMTGWPVLMAL
SNKDVVGETLGVDLTERLEGTLAATALAAAAGARMFRVHEVAATRRVLEM
VASIQGVRPPTRTVRGLA
>Rv0562 grcC1, PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE)
MRTPATVVAGVDLGDAVFAAAVRAGVARVEQLMDTELRQADEVMSDSLLH
LFNAGGKRFRPLFTVLSAQIGPQPDAAAVTVAGAVIEMIHLATLYHDDVM
DEAQVRRGAPSANAQWGNNVAILAGDYLLATASRLVARLGPEAVRIIADT
FAQLVTGQMRETRGTSENVDSIEQYLKVVQEKTGSLIGAAGRLGGMFSGA
TDEQVERLSRLGGVVGTAFQIADDIIDIDSESDESGKLPGTDVREGVHTL
PMLYALRESGPDCARLRALLNGPVDDDAEVREALTLLRASPGMARAKDVL
AQYAAQARHELALLPDVPGRRALAALVDYTVSRHG
>Rv0989c grcC2, PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC2 (POLYPRENYL PYROPHOSPHATE SYNTHETASE)
MIPAVSLGDPQFTANVHDGIARITELINSELSQADEVMRDTVAHLVDAGG
TPFRPLFTVLAAQLGSDPDGWEVTVAGAAIELMHLGTLCHDRVVDESDMS
RKTPSDNTRWTNNFAILAGDYRFATASQLASRLDPEAFAVVAEAFAELIT
GQMRATRGPASHIDTIEHYLRVVHEKTGSLIAASGQLGAALSGAAEEQIR
RVARLGRMIGAAFEISRDIIAISGDSATLSGADLGQAVHTLPMLYALREQ
TPDTSRLRELLAGPIHDDHVAEALTLLRCSPGIGKAKNVVAAYAAQAREE
LPYLPDRQPRRALATLIDHAISACD
>Rv3704c gshA, GLUTAMATE--CYSTEINE LIGASE GSHA (GAMMA-GLUTAMYLCYSTEINE SYNTHETASE) (GAMMA-ECS) (GCS) (GAMMA-GLUTAMYL-L-CYSTEINE SYNTHETASE)
MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEM
EAHCFDPADPFRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPA
DGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPVRVNPGARYRA
MEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVRLAHALGPTM
IAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAK
YALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH
LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDA
VEPVATAWDTAARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDH
VDRGVCPADDFSDRVIAGGIASAVTGMMHGAS
>Rv0509 hemA, PROBABLE GLUTAMYL-TRNA REDUCTASE HEMA (GLUTR)
MSVLLFGVSHRSAPVVVLEQLSIDESDQVKIIDRVLASPLVTEAMVLSTC
NRVEVYAVVDAFHGGLSVIGQVLAEHSGMSMGELTKYAYVRYSEAAVEHL
FAVASGLDSAVIGEQQVLGQVRRAYAVAESNRTVGRVLHELAQRALSVGK
RVHSETAIDAAGASVVSVALGMAERKLGSLAGTTAVVIGAGAMGALSAVH
LTRAGVGHIQVLNRSLSRAQRLARRIRESGVPAEALALDRLANVLADADV
VVSCTGAVRPVVSLADVHHALAAARRDEATRPLVICDLGMPRDVDPAVAR
LPCVWVVDVDSVQHEPSAHAAAADVEAARHIVAAEVASYLVGQRMAEVTP
TVTALRQRAAEVVEAELLRLDNRLPGLQSVQREEVARTVRRVVDKLLHAP
TVRIKQLASAPGGDSYAEALRELFELDQTAVDAVATAGELPVVPSGFDAE
SRRGGGDMQSSPKRSPSN
>Rv0512 hemB, PROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH)
MSMSSYPRQRPRRLRSTVAMRRLVAQTSLEPRHLVLPMFVADGIDEPRPI
TSMPGVVQHTRDSLRRAAAAAVAAGVGGLMLFGVPRDQDKDGVGSAGIDP
DGILNVALRDLAKDLGEATVLMADTCLDEFTDHGHCGVLDDRGRVDNDAT
VARYVELAVAQAESGAHVVGPSGMMDGQVAAIRDGLDAAGYIDVVILAYA
AKFASAFYGPFREAVSSSLSGDRRTYQQEPGNAAEALREIELDLDEGADI
VMVKPAMGYLDVVAAAADVSPVPVAAYQVSGEYAMIRAAAANNWIDERAA
VLESLTGIRRAGADIVLTYWAVDAAGWLT
>Rv0510 hemC, PROBABLE PORPHOBILINOGEN DEAMINASE HEMC (PBG) (HYDROXYMETHYLBILANE SYNTHASE) (HMBS) (PRE-UROPORPHYRINOGEN SYNTHASE)
MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLG
VGVFTTALREAMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAV
VARDGLTLGELPVGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNK
VSSGDLDAIVVARAGLARLGRLDDVTETLEPVQMLPAPAQGALAVECRAG
DSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAIAEVVESIDE
DGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA
RELMWGVRH
>Rv0511 hemD, PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE HEMD (UROPORPHYRINOGEN III METHYLASE) (UROGEN III METHYLASE) (SUMT) (UROGEN III METHYLASE) (UROM)
MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVV
ALIGTDLPPVSGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRP
ALGDPADVAKTLTAEARSGVDVVRLVAGDPLTVDAVISEVNAVARTHLHI
EIVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTDWDALAAAPGPLIL
QATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVETTLQGLTDPA
VLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV
PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRF
QWIVFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGIS
PELVPSGEQSSLGLLDDFPPYDSVFDPVNRVLLPRADIATETLAEGLRER
GWEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTSSSTVRNLVGIAG
KPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAARLR
AEGALPPPRKKSRRR
>Rv2678c hemE, PROBABLE UROPORPHYRINOGEN DECARBOXYLASE HEME (UROPORPHYRINOGEN III DECARBOXYLASE) (URO-D) (UPD)
MSTRRDLPQSPYLAAVTGRKPSRVPVWFMRQAGRSLPEYRALRERYSMLA
ACFEPDVACEITLQPIRRYDVDAAILFSDIVVPLRAAGVDLDIVADVGPV
IADPVRTAADVAAMKPLDPQAIQPVLVAASLLVAELGDVPLIGFAGAPFT
LASYLVEGGPSRHHAHVKAMMLAEPASWHALMAKLTDLTIAFLVGQIDAG
VDAIQVFDSWAGALSPIDYRQYVLPHSARVFAALGEHGVPMTHFGVGTAE
LLGAMSEAVTAGERPGRGAVVGVDWRTPLTDAAARVVPGTALQGNLDPAV
VLAGWPAVERAARAVVDDGRRAVDAGAAGHIFNLGHGVLPESDPAVLADL
VSLVHSL
>Rv0524 hemL, PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT)
MGSTEQATSRVRGAARTSAQLFEAACSVIPGGVNSPVRAFTAVGGTPRFI
TEAHGCWLIDADGNRYVDLVCSWGPMILGHAHPAVVEAVAKAAARGLSFG
APTPAETQLAGEIIGRVAPVERIRLVNSGTEATMSAVRLARGFTGRAKIV
KFSGCYHGHVDALLADAGSGVATLGLCDDPQRPASPRSQSSRGLPSSPGV
TGAAAADTIVLPYNDIDAVQQTFARFGEQIAAVITEASPGNMGVVPPGPG
FNAALRAITAEHGALLILDEVMTGFRVSRSGWYGIDPVPADLFAFGKVMS
GGMPAAAFGGRAEVMQRLAPLGPVYQAGTLSGNPVAVAAGLATLRAADDA
VYTALDANADRLAGLLSEALTDAVVPHQISRAGNMLSVFFGETPVTDFAS
ARASQTWRYPAFFHAMLDAGVYPPCSAFEAWFVSAALDDAAFGRIANALP
AAARAAAQERPA
>Rv2388c hemN, PROBABLE OXYGEN-INDEPENDENT COPROPORPHYRINOGEN III OXIDASE HEMN (COPROPORPHYRINOGENASE) (COPROGEN OXIDASE)
MPGQPFGVYLHVPFCLTRCGYCDFNTYTPAQLGGVSPDRWLLALRAELEL
AAAKLDAPTVHTVYVGGGTPSLLGGERLATLLDMVRDHFVLAPDAEVSTE
ANPESTWPEFFATIRAAGYTRVSLGMQSVAPRVLATLDRVHSPGRAAAAA
TEAIAEGFTHVNLDLIYGTPGESDDDLVRSVDAAVQAGVDHVSAYALVVE
HGTALARRVRRGELAAPDDDVLAHRYELVDARLSAAGFAWYEVSNWCRPG
GECRHNLGYWDGGQWWGAGPGAHGYIGVTRWWNVKHPNTYAEILAGATLP
VAGFEQLGADALHTEDVLLKVRLRQGLPLARLGAAERERAEAVLADGLLD
YHGDRLVLTGRGRLLADAVVRTLLG
>Rv2677c hemY, PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)
MTPRSYCVVGGGISGLTSAYRLRQAVGDDATITLFEPADRLGGVLRTEHI
GGQPMDLGAEAFVLRRPEMPALLAELGLSDRQLASTGARPLIYSQQRLHP
LPPQTVVGIPSSAGSMAGLVDDATLARIDAEAARPFTWQVGSDPAVADLV
ADRFGDQVVARSVDPLLSGVYAGSAATIGLRAAAPSVAAALDRGATSVTD
AVRQALPPGSGGPVFGALDGGYQVLLDGLVRRSRVHWVRARVVQLERGWV
LRDETGGRWQADAVILAVPAPRLARLVDGIAPRTHAAARQIVSASSAVVA
LAVPGGTAFPHCSGVLVAGDESPHAKAITLSSRKWGQRGDVALLRLSFGR
FGDEPALTASDDQLLAWAADDLVTVFGVAVDPVDVRVRRWIEAMPQYGPG
HADVVAELRAGLPPTLAVAGSYLDGIGVPACVGAAGRAVTSVIEALDAQV
AR
>Rv1485 hemZ, FERROCHELATASE HEMZ (PROTOHEME FERRO-LYASE) (HEME SYNTHETASE)
MQFDAVLLLSFGGPEGPEQVRPFLENVTRGRGVPAERLDAVAEHYLHFGG
VSPINGINRTLIAELEAQQELPVYFGNRNWEPYVEDAVTAMRDNGVRRAA
VFATSAWSGYSSCTQYVEDIARARRAAGRDAPELVKLRPYFDHPLFVEMF
ADAITAAAATVRGDARLVFTAHSIPTAADRRCGPNLYSRQVAYATRLVAA
AAGYCDFDLAWQSRSGPPQVPWLEPDVTDQLTGLAGAGINAVIVCPIGFV
ADHIEVVWDLDHELRLQAEAAGIAYARASTPNADPRFARLARGLIDELRY
GRIPARVSGPDPVPGCLSSINGQPCRPPHCVASVSPARPSAGSP
>Rv3398c idsA1, PROBABLE MULTIFUNCTIONAL GERANYLGERANYL PYROPHOSPHATE SYNTHETASE IDSA1 (GGPP SYNTHETASE) (GGPPSASE) (GERANYLGERANYL DIPHOSPHATE SYNTHASE): DIMETHYLALL
MRGTDEKYGLPPQPDSDRMTRRTLPVLGLAHELITPTLRQMADRLDPHMR
PVVSYHLGWSDERGRPVNNNCGKAIRPALVFVAAEAAGADPHSAIPGAVS
VELVHNFSLVHDDLMDRDEHRRHRPTVWALWGDAMALLAGDAMLSLAHEV
LLDCDSPHVGAALRAISEATRELIRGQAADTAFESRTDVALDECLKMAEG
KTAALMAASAEVGALLAGAPRSVREALVAYGRHIGLAFQLVDDLLGIWGR
PEITGKPVYSDLRSRKKTLPVTWTVAHGGSAGRRLAAWLVDETGSQTASD
DELAAVAELIECGGGRRWASAEARRHVTQGIDMVARIGIPDRPAAELQDL
AHYIVDRQA
>Rv2173 idsA2, PROBABLE GERANYLGERANYL PYROPHOSPHATE SYNTHETASE IDSA2 (GGPPSASE) (GGPP SYNTHETASE) (GERANYLGERANYL DIPHOSPHATE SYNTHASE)
MAGAITDQLRRYLHGRRRAAAHMGSDYDGLIADLEDFVLGGGKRLRPLFA
YWGWHAVASREPDPDVLLLFSALELLHAWALVHDDLIDRSATRRGRPTAQ
LRYAALHRDRDWRGSPDQFGMSAAILLGDLAQVWADDIVSKVCQSALAPD
AQRRVHRVWADIRNEVLGGQYLDIVAEASAAESIESAMNVATLKTACYTV
SRPLQLGTAAAADRSDVAAIFEHFGADLGVAFQLRDDVLGVFGDPAVTGK
PSGDDLKSGKRTVLVAEAVELADRSDPLAAKLLRTSIGTRLTDAQVRELR
TVIEAVGARAAAESRIAALTQRALATLASAPINATAKAGLSELAMMAANR
SA
>Rv3383c idsB, POSSIBLE POLYPRENYL SYNTHETASE IDSB (POLYPRENYL TRANSFERASE) (POLYPRENYL DIPHOSPHATE SYNTHASE)
MGGVLTLDAAFLGSVPADLGKALLERARADCGPVLHRAIESMREPLATMA
GYHLGWWNADRSTAAGSSGKYFRAALVYAAAAACGGDVGDATPVSAAVEL
VHNFTLLHDDVMDGDATRRGRPTVWSVWGVGVAILLGDALHATAVRILTG
LTDECVAVRAIRRLQMSCLDLCIGQFEDCLLEGQPEVTVDDYLRMAAGKT
AALTGCCCALGALVANADDATIAALERFGHELGLAFQCVDDLIGIWGDPG
VTGKPVGNDLARRKATLPVVAALNSRSEAATELAALYQAPAAMTASDVER
ATALVKVAGGGHVAQRCADERIQAAIAALPDAVRSPDLIALSQLICRREC
>Rv3003c ilvB1, PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB1 (ACETOHYDROXY-ACID SYNTHASE)
MSAPTKPHSPTFKPEPHSAANEPKHPAARPKHVALQQLTGAQAVIRSLEE
LGVDVIFGIPGGAVLPVYDPLFDSKKLRHVLVRHEQGAGHAASGYAHVTG
RVGVCMATSGPGATNLVTPLADAQMDSIPVVAITGQVGRGLIGTDAFQEA
DISGITMPITKHNFLVRSGDDIPRVLAEAFHIAASGRPGAVLVDIPKDVL
QGQCTFSWPPRMELPGYKPNTKPHSRQVREAAKLIAAARKPVLYVGGGVI
RGEATEQLRELAELTGIPVVTTLMARGAFPDSHRQNLGMPGMHGTVAAVA
ALQRSDLLIALGTRFDDRVTGKLDSFAPEAKVIHADIDPAEIGKNRHADV
PIVGDVKAVITELIAMLRHHHIPGTIEMADWWAYLNGVRKTYPLSYGPQS
DGSLSPEYVIEKLGEIAGPDAVFVAGVGQHQMWAAQFIRYEKPRSWLNSG
GLGTMGFAIPAAMGAKIALPGTEVWAIDGDGCFQMTNQELATCAVEGIPV
KVALINNGNLGMVRQWQSLFYAERYSQTDLATHSHRIPDFVKLAEALGCV
GLRCEREEDVVDVINQARAINDCPVVIDFIVGADAQVWPMVAAGTSNDEI
QAARGIRPLFDDITEGHA
>Rv3470c ilvB2, PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB2 (AHAS) (ACETOHYDROXY-ACID SYNTHASE LARGE SUBUNIT) (ALS)
MTVGDHLVARMRAAGISVVCGLPTSRLDSLLVRLSRDAGFQIVLARHEGG
AGYLADGFARASGKSAAVFVAGPGATNVISAVANASVNQVPMLILTGEVA
VGEFGLHSQQDTSDDGLGLGATFRRFCRCSVSIESIANARSKIDSAFRAL
ASIPRGPVHIALPRDLVDERLPAHQLGTAAAGLGGLRTLAPCGPDVADEV
IGRLDRSRAPMLVLGNGCRLDGIGEQIVAFCEKAGLPFATTPNGRGIVAE
THPLSLGVLGIFGDGRADEYLFDTPCDLLIAVGVSFGGLVTRSFSPRWRG
LKADVVHVDPDPSAVGRFVATSLGITTSGRAFVNALNCGRPPRFCRRVGV
RPPAPAALPGTPQARGESIHPLELMHELDRELAPNATICADVGTCISWTF
RGIPVRRPGRFFATVDFSPMGCGIAGAIGVALARPEEHVICIAGDGAFLM
HGTEISTAVAHGIRVTWAVLNDGQMSASAGPVSGRMDPSPVARIGANDLA
AMARALGAEGIRVDTRCELRAGVQKALAATGPCVLDIAIDPEINKPDIGL
GR
>Rv3001c ilvC, PROBABLE KETOL-ACID REDUCTOISOMERASE ILVC (Acetohydroxy-acid isomeroreductase) (Alpha-keto-beta-hydroxylacil reductoisomerase)
MFYDDDADLSIIQGRKVGVIGYGSQGHAHSLSLRDSGVQVRVGLKQGSRS
RPKVEEQGLDVDTPAEVAKWADVVMVLAPDTAQAEIFAGDIEPNLKPGDA
LFFGHGLNVHFGLIKPPADVAVAMVAPKGPGHLVRRQFVDGKGVPCLVAV
EQDPRGDGLALALSYAKAIGGTRAGVIKTTFKDETETDLFGEQTVLCGGT
EELVKAGFEVMVEAGYPAELAYFEVLHELKLIVDLMYEGGLARMYYSVSD
TAEFGGYLSGPRVIDAGTKERMRDILREIQDGSFVHKLVADVEGGNKQLE
ELRRQNAEHPIEVVGKKLRDLMSWVDRPITETA
>Rv2210c ilvE, PROBABLE BRANCHED-CHAIN AMINO ACID TRANSAMINASE ILVE
MTSGSLQFTVLRAVNPATDAQRESMLREPGFGKYHTDHMVSIDYAEGRGW
HNARVIPYGPIELDPSAIVLHYAQEVFEGLKAYRWADGSIVSFRADANAA
RLRSSARRLAIPELPDAVFIESLRQLIAVDKAWVPGAGGEEALYLRPFIF
ATEPGLGVRPATQYRYLLIASPAGAYFKGGIAPVSVWVSTEYVRACPGGT
GAAKFGGNYAASLLAQAEAAENGCDQVVWLDAVERRYIEEMGGMNIFFVL
GSGGSARLVTPELSGSLLPGITRDSLLQLAIDAGFAVEERRIDIDEWQKK
AAAGEITEVFACGTAAVITPVARVRHGASEFRIADGQPGEVTMALRDTLT
GIQRGTFADTHGWMARLG
>Rv1820 ilvG, Probable Acetolactate synthase ilvG (Acetohydroxy-acid synthase)(ALS)
MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIR
LIDTRHEQTAAFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQS
PLVVLGGRAPALRWGMGSLQEIDHVPFVAPVARFAATAQSAENAGLLVDQ
ALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGALTELPAGPTPAGDALD
RAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMARGVV
PADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR
VEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARD
LEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSY
LPGCWLDSGPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWD
TLVRHNVAVVSVIGNNGIWGLEKHPMEALYGYSVVAELRPGTRYDEVVRA
LGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAYPRRSNLA
>Rv3509c ilvX, PROBABLE ACETOHYDROXYACID SYNTHASE ILVX (ACETOLACTATE SYNTHASE)
MNGAQALINTLVDGGVDVCFANPGTSEMHFVAALDAVPRMRGMLTLFEGV
ATGAADGYARIAGRPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDH
ATYHKKYDAPLESDIDAVAGTVSGWVRRTEAAADVGADAEAAIAASRSGS
QIATLILPADVCWSDGAHAAAGVPAQAAAAPVDVGPVAGVLRSGEPAMML
IGGDATRGPGLTAAARIVQATGARWLCETFPTCLERGAGIPAVERLAYFA
EGAAAQLDGVKHLVLAGARSPVSFFAYPGMPSDLVPAGCEVHVLAEPGGA
ADALAALADEVAPGTVAPVAGASRPQLPTGDLTSVSAADVVGALLPERAI
VVDESNTCGVLLPQATAGAPAHDWLTLTGGAIGYGIPAAVGAAVAAPDRP
VLCLESDGSAMYTISGLWSQARENLDVTTVIYNNGAYDILRIELQRVGAG
SDPGPKALDLLDISRPTMDFVKIAEGMGVPARRVTTCEEFADALRAAFAE
PGPHLIDVVVPSLVG
>Rv2965c kdtB, PROBABLE PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE KDTB (PANTETHEINE-PHOSPHATE ADENYLYLTRANSFERASE) (PPAT) (DEPHOSPHO-CoA PYROPHOSPHORYLASE)
MTGAVCPGSFDPVTLGHVDIFERAAAQFDEVVVAILVNPAKTGMFDLDER
IAMVKESTTHLPNLRVQVGHGLVVDFVRSCGMTAIVKGLRTGTDFEYELQ
MAQMNKHIAGVDTFFVATAPRYSFVSSSLAKEVAMLGGDVSELLPEPVNR
RLRDRLNTERT
>Rv2218 lipA, Probable lipoate biosynthesis protein A LipA
MSVAAEGRRLLRLEVRNAQTPIERKPPWIKTRARIGPEYTELKNLVRREG
LHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQIDTGKPAELDR
DEPRRVADSVRTMGLRYATVTGVARDDLPDGGAWLYAATVRAIKELNPST
GVELLIPDFNGEPTRLAEVFESGPEVLAHNVETVPRIFKRIRPAFTYRRS
LGVLTAARDAGLVTKSNLILGLGETSDEVRTALGDLRDAGCDIVTITQYL
RPSARHHPVERWVKPEEFVQFARFAEGLGFAGVLAGPLVRSSYRAGRLYE
QARNSRALASR
>Rv2217 lipB, Probable lipoate biosynthesis protein B LipB
MTGSIRSKLSAIDVRQLGTVDYRTAWQLQRELADARVAGGADTLLLLEHP
AVYTAGRRTETHERPIDGTPVVDTDRGGKITWHGPGQLVGYPIIGLAEPL
DVVNYVRRLEESLIQVCADLGLHAGRVDGRSGVWLPGRPARKVAAIGVRV
SRATTLHGFALNCDCDLAAFTAIVPCGISDAAVTSLSAELGRTVTVDEVR
ATVAAAVCAALDGVLPVGDRVPSHAVPSPL
>Rv2386c mbtI, PUTATIVE ISOCHORISMATE SYNTHASE MBTI
MSELSVATGAVSTASSSIPMPAGVNPADLAAELAAVVTESVDEDYLLYEC
DGQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSGRPGAALGEAVDRLL
LETDQAFGWVAFEFGVHRYGLQQRLAPHTPLARVFSPRTRIMVSEKEIRL
FDAGIRHREAIDRLLATGVREVPQSRSVDVSDDPSGFRRRVAVAVDEIAA
GRYHKVILSRCVEVPFAIDFPLTYRLGRRHNTPVRSFLLQLGGIRALGYS
PELVTAVRADGVVITEPLAGTRALGRGPAIDRLARDDLESNSKEIVEHAI
SVRSSLEEITDIAEPGSAAVIDFMTVRERGSVQHLGSTIRARLDPSSDRM
AALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADGGLDA
ALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYLVARQ
>Rv0534c menA, 1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE MENA (DHNA-OCTAPRENYLTRANSFERASE)
MASFAQWVSGARPRTLPNAIAPVVAGTGAAAWLHAAVWWKALLALAVAVA
LVIGVNYANDYSDGIRGTDDDRVGPVRLVGSRLATPRSVLTAAMTSLALG
ALAGLVLALLSAPWLIAVGAICIAGAWLYTGGSKPYGYAGFGELAVFVFF
GPVAVLGTQYTQALRVDWVGLAQAVATGALSCSVLVANNLRDIPTDARAD
KITLAVRLGDARTRMLYQGLLAVAGVLTFVLMLATPWCVVGLVAAPLALR
AAGPVRSGRGGRELIPVLRDTGLAMLVWALAVAGALAFGQLS
>Rv0548c menB, PROBABLE NAPHTHOATE SYNTHASE MENB (DIHYDROXYNAPHTHOIC ACID SYNTHETASE) (DHNA SYNTHETASE)
MVAPAGEQGRSSTALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRV
AFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWA
FCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVV
ICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYL
ARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEI
NAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFL
QKRPPDWSPFPRYF
>Rv0555 menD, PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SHCHC SYNTHASE) + 2-OXOG
MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLH
VRIDERTAGYLAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPL
IVLSANRPYELLGTGANQTMEQLGYFGTQVRASISLGLAEDAPERTSALN
ATWRSATCRVLAAATGARTANAGPVHFDIPLREPLVPDPEPLGAVTPPGR
PAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNLAALPTVAEPT
APRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT
GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAH
PLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRG
VAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGL
LIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVD
VGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADRSSLRQLHAAI
KAAL
>Rv3853 menG, PROBABLES-ADENOSYLMETHIONINE:2- DEMETHYLMENAQUINONE METHYLTRANSFERASE MENG
MAISFRPTADLVDDIGPDVRSCDLQFRQFGGRSQFAGPISTVRCFQDNAL
LKSVLSQPSAGGVLVIDGAGSLHTALVGDVIAELARSTGWTGLIVHGAVR
DAAALRGIDIGIKALGTNPRKSTKTGAGERDVEITLGGVTFVPGDIAYSD
DDGIIVV
>Rv0558 menH, PROBABLE UBIQUINONE/MENAQUINONE BIOSYNTHESIS METHYLTRANSFERASE MENH (2-heptaprenyl-1,4-naphthoquinone methyltransferase)
MSRAALDKDPRDVASMFDGVARKYDLTNTVLSLGQDRYWRRATRSALRIG
PGQKVLDLAAGTAVSTVELTKSGAWCVAADFSVGMLAAGAARKVPKVAGD
ATRLPFGDDVFDAVTISFGLRNVANQQAALREMARVTRPGGRLLVCEFST
PTNALFATAYKEYLMRALPRVARAVSSNPEAYEYLAESIRAWPDQAVLAH
QISRAGWSGVRWRNLTGGIVALHAGYKPGKQTPQ
>Rv1392 metK, PROBABLE S-ADENOSYLMETHIONINE SYNTHETASE METK (MAT) (AdoMet synthetase) (Methionine adenosyltransferase)
MSEKGRLFTSESVTEGHPDKICDAISDSVLDALLAADPRSRVAVETLVTT
GQVHVVGEVTTSAKEAFADITNTVRARILEIGYDSSDKGFDGATCGVNIG
IGAQSPDIAQGVDTAHEARVEGAADPLDSQGAGDQGLMFGYAINATPELM
PLPIALAHRLSRRLTEVRKNGVLPYLRPDGKTQVTIAYEDNVPVRLDTVV
ISTQHAADIDLEKTLDPDIREKVLNTVLDDLAHETLDASTVRVLVNPTGK
FVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMR
WVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVETFGTETEDPVKIEKAI
GEVFDLRPGAIIRDLNLLRPIYAPTAAYGHFGRTDVELPWEQLDKVDDLK
RAI
>Rv3109 moaA1, PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A MOAA1
MSTPTLPDMVAPSPRVRVKDRCRRMMGDLRLSVIDQCNLRCRYCMPEEHY
TWLPRQDLLSVKEISAIVDVFLSVGVSKVRITGGEPLIRPDLPEIVRTLS
AKVGEDSGLRDLAITTNGVLLADRVDGLKAAGMKRITVSLDTLQPERFKA
ISQRNSHDKVIAGIKAVAAAGFTDTKIDTTVMRGANHDELADLIEFARTV
NAEVRFIEYMDVGGATHWAWEKVFTKANMLESLEKRYGRIEPLPKHDTAP
ANRYALPDGTTFGIIASTTEPFCATCDRSRLTADGLWLHCLYAISGINLR
EPLRAGATHDDLVETVTTGWRRRTDRGAEQRLAQRERGVFLPLSTLKADP
HLEMHTRGG
>Rv0869c moaA2, PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A2 MOAA2
MTLTALGMPALRSRTNGIADPRVVPTTGPLVDTFGRVANDLRVSLTDRCN
LRCSYCMPERGLRWLPGEQLLRPDELARLIHIAVTRLGVTSVRFTGGEPL
LAHHLDEVVAATARLRPRPEISLTTNGVGLARRAGALAEAGLDRVNVSLD
SIDRAHFAAITRRDRLAHVLAGLAAAKAAGLTPVKVNAVLDPTTGREDVV
DLLRFCLERGYQLRVIEQMPLDAGHSWRRNIALSADDVLAALRPHFRLRP
DPAPRGSAPAELWLVDAGPNTPRGRFGVIASVSHAFCSTCDRTRLTADGQ
IRSCLFSTEETDLRRLLRGGADDDAIEAAWRAAMWSKPAGHGINAPDFIQ
PDRPMSAIGG
>Rv3110 moaB1, PROBABLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE MOAB1 (PHS) (4-ALPHA-HYDROXY-TETRAHYDROPTERIN DEHYDRATASE) (PTERIN-4-A-CARBINOLAMINE DEHYDRATASE) (P
MTVSTPEQHEQRASHDASEGKHNVCQGRLAALADAAVSEKLGALPGWQLL
DMRLSRAFQCTNFDQSIDFMNRVASIANDINHHPDIAVLDKRSVRVTAWT
RKLGYLTDIDFDLAASVEAMYATEFADRPAR
>Rv0984 moaB2, POSSIBLE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE MOAB2 (PHS) (4-ALPHA-HYDROXY-TETRAHYDROPTERIN DEHYDRATASE) (PTERIN-4-A-CARBINOLAMINE DEHYDRATASE) (P
MKVAAQCSKLGYTVAPMEQRAELVVGRALVVVVDDRTAHGDEDHSGPLVT
ELLTEAGFVVDGVVAVSADEVEIRNALNTAVIGGVDLVVSVGGTGVTPRD
VTPEATRDILDREILGIAEAIRASGLSAGIVDAGLSRGLAGVSGSTLVVN
LAGSRYAVRDGMATLNPLAAQIIGQLSSLEI
>Rv3111 moaC1, PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C MOAC1
MIDHALALTHIDERGAARMVDVSEKPVTLRVAKASGLVIMKPSTLRMISD
GAAAKGDVMAAARIAGIAAAKRTGDLIPLCHPLGLDAVSVTITPCEPDRV
KILATTTTLGRTGVEMEALTAVSVAALTIYDMCKAVDRAMEISQIVLQEK
SGGRSGVYRRSASDLACQSR
>Rv0864 moaC2, PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C 2 MOAC2
MARASGASDYRSGELSHQDERGAAHMVDITEKATTKRTAVAAGILRTSAQ
VVALISTGGLPKGDALATARVAGIMAAKRTSDLIPLCHQLALTGVDVDFT
VGQLDIEITATVRSTDRTGVEMEALTAVSVAALTLYDMIKAVDPGALIDD
IRVLHKEGGRRGTWTRR
>Rv3324c moaC3, PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C 3 MOAC3
MNDHDGVLTHLDEQGAARMVDVSAKAVTLRRARASGAVLMKPSTLDMICH
GTAAKGDVIATARIAGIMAAKRTGELIPLCHPLGIEAVTVTLEPQGADRL
SIAATVTTVARTGVEMEALTAVTVTALTVYDMCKAVDRAMTITDIRLDEK
SGGRSGHYRRHDADVKPSDGGSTEDGC
>Rv3112 moaD1, PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D MOAD1 (MOLYBDOPTERIN CONVERTING FACTOR SMALL SUBUNIT) (MOLYBDOPTERIN [MPT] CONVERTING FACTOR, SUBU
MIKVNVLYFGAVREACDETPREEVEVQNGTDVGNLVDQLQQKYPRLRDHC
QRVQMAVNQFIAPLSTVLGDGDEVAFIPQVAGG
>Rv0868c moaD2, PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN D 2 MOAD2 (MOLYBDOPTERIN CONVERTING FACTOR SMALL SUBUNIT) (MOLYBDOPTERIN [MPT] CONVERTING FACTOR, SU
MTQVSDESAGIQVTVRYFAAARAAAGAGSEKVTLRSGATVAELIDGLSVR
DVRLATVLSRCSYLRDGIVVRDDAVALSAGDTIDVLPPFAGG
>Rv3119 moaE1, PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN E MOAE1 (MOLYBDOPTERIN CONVERTING FACTOR LARGE SUBUNIT) (MOLYBDOPTERIN [MPT] CONVERTING FACTOR, SUBU
MANVVAEGAYPYCRLTDQPLSVDEVLAAVSGPEQGGIVIFVGNVRDHNAG
HDVTRLFYEAYPPMVIRTLMSIIGRCEDKAEGVRVAVAHRTGELQIGDAA
VVIGASAPHRAEAFDAARMCIELLKQEVPIWKKEFSSTGAEWVGDRP
>Rv0866 moaE2, PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN E2 MOAE2 (MOLYBDOPTERIN CONVERTING FACTOR LARGE SUBUNIT) (MOLYBDOPTERIN [MPT] CONVERTING FACTOR, SUB
MTQVLRAALTDQPIFLAEHEELVSHRSAGAIVGFVGMIRDRDGGRGVLRL
EYSAHPSAAQVLADLVAEVAEESSGVRAVAASHRIGVLQVGEAALVAAVA
ADHRRAAFGTCAHLVETIKARLPVWKHQFFEDGTDEWVGSV
>Rv3323c moaX, PROBABLE MOAD-MOAE FUSION PROTEIN MOAX
MITVNVLYFGAVREACKVAHEKISLESGTTVDGLVDQLQIDYPPLADFRK
RVRMAVNESIAPASTILDDGDTVAFIPQVAGGSDVYCRLTDEPLSVDEVL
NAISGPSQGGAVIFVGTVRNNNNGHEVTKLYYEAYPAMVHRTLMDIIEEC
ERQADGVRVAVAHRTGELRIGDAAVVIGASAPHRAAAFDAARMCIERLKQ
DVPIWKKEFALDGVEWVANRP
>Rv2453c mobA, PROBABLE MOLYBDOPTERIN-GUANINE DINUCLEOTIDE BIOSYNTHESIS PROTEIN A MOBA
MAELAPDTVPLAGVVLAGGESRRMGRDKATLPLPGGTTTLVEHMVGILGQ
RCAPVFVMAAPGQPLPTLPVPVLRDELPGLGPLPATGRGLRAAAEAGVRL
AFVCAVDMPYLTVELIEDLARRAVQTDAEVVLPWDGRNHYLAAVYRTDLA
DRVDTLVGAGERKMSALVDASDALRIVMADSRPLTNVNSAAGLHAPMQPG
R
>Rv0994 moeA1, PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEA1
MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAA
IDGYAVRSVDVAGVGDTGGVQVFADHGDLDGRDVLTLPVMGTIEAGARTL
SRLQPRQAVRVQTGAPLPTLADAVLPLRWTDGGMSRVRVLRGAPSGAYVR
RAGDDVQPGDVAVRAGTIIGAAQVGLLAAVGRERVLVHPRPRLSVMAVGG
ELVDISRTPGNGQVYDVNSYALAAAGRDACAEVNRVGIVSNDPTELGEIV
EGQLNRAEVVVIAGGVGGAAAEAVRSVLSELGEMEVVRVAMHPGSVQGFG
QLGRDGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRHPMRRIVSARTL
SPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANC
LVVVPTGAEQIRTGEIVDVAFLAQHG
>Rv0438c moeA2, PROBABLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEA2
MRSVQEHQRVVAEMMRACRPITVPLTQAQGLVLGGDVVAPLSLPVFDNSA
MDGYAVRAEDTSGATPQNPVMLPVAEDIPAGRADMLTLQPVTAHRIMTGA
PVPTGATAIVPVEATDGGVDSVAIRQQATPGKHIRRSGEDVAAGTTVLHN
GQIVTPAVLGLAAALGLAELPVLPRQRVLVISTGSELASPGTPLQPGQIY
ESNSIMLAAAVRDAGAAVVATATAGDDVAQFGAILDRYAVDADLIITSGG
VSAGAYEVVKDAFGSADYRGGDHGVEFVKVAMQPGMPQGVGRVAGTPIVT
LPGNPVSALVSFEVFIRPPLRMAMGLPDPYRPHRSAVLTASLTSPRGKRQ
FRRAILDHQAGTVISYGPPASHHLRWLASANGLLDIPEDVVEVAAGTQLQ
VWDLT
>Rv2338c moeW, POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEW
MRAGADAPDSGRVKESAPWSYDEAFCRNLGLISPTEQQRLRNSRVAIAGM
GGVGGIDMVALARMGIGKFTIADPDVFEIRNSNRQYGAMRSTNGQAKAEV
MRNIVHDINPEAEIRAFCEPIGKENAATFLEGADVLVDGIDAFEIDLRRL
LYREAQQRGIYALGAGPLGFSTAWVVFDPKGMTFDRYFDLSDAMNTVDKF
VAFIAGIAPSATHRRSIDLSYVDIENRTGPSVGLACHLASGVVAAEVLKI
LLGHGRVYAAPYFHQFDAYRSIYVRKRLRCGNRHPLQRVKRRLLARYINR
RSAGVIPGLRYHRTEPSY
>Rv1355c moeY, POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEY
MTIPHEGGSTGILVLRDDDHDDVLVLDRLRSDPSIEFVDRFAEQLAGVRR
LLPQPDPDLLEEAKRWAYYPWRRMVVAILGLRGFRAVRLDRNRHLITAEE
QRALHALRVGVVGLSAGHAIAYTLAAEGACGTLRLADFDKIELSNLNRVP
VGVFDIGLNKAMIAARRIAELDPYLAVDLVTSGLSPESVDEFLDGLDVVI
EECDSLDIKVILRQAACARGVPVLMATSDRGLVDVERYDVEPGRPIFHGL
LGDIDADKLCGLTTKDKVPHVLNILDCQELSARCAASMIEVDQTLWGWPQ
LAGDIWVGAATVAEAVRRIGLGEPLESGRVRVDVSAALDRLDQPPMPSRG
NGWLLESVPPTAPAEPQPTSEIVAQAAIRAPSGGNVQPWHVVAKQHSLTI
RLAPEHTSAMDIAFRGSAVAVGAAMFNARVAAAAHRVLGSVEFDESQPDS
PLQATMHFGRGDDPSLAALYRPMLLRTTNRHHGMPGHVHPATVELLTNTA
AAEGARLQLLLSRNEIDRAATILAAADRIRYLTPRLHEEMMSELRWPGDP
SLDAGIDVRSLELDSGELRVLDILRRSDVVARLAQWDCGTALEDNTNERV
SASSALAIVYVDGATLTDFARGGSAMQAVWIVAQQHGLAVQPMSPIFLYA
RGRHDLDQASPHFAAQLHRLQLDFRELVKPGKEGHEVLIFRLFHAPPPSV
CSRRRVRHAIPEPHR
>Rv0865 mog, PROBABLE MOLYBDOPTERIN BIOSYNTHESIS MOG PROTEIN
MSTRSARIVVVSSRAAAGVYTDDCGPIIAGWLEQHGFSSVQPQVVADGNP
VGEALHDAVNAGVDVIITSGGTGISPTDTTPEHTVAVLDYVIPGLADAIR
RSGLPKVPTSVLSRGVCGVAGRTLIINLPGSPGGVRDGLGVLADVLDHAL
EQIAGGDHPR
>Rv1594 nadA, Probable quinolinate synthetase nadA
MTVLNRTDTLVDELTADITNTPLGYGGVDGDERWAAEIRRLAHLRGATVL
AHNYQLPAIQDVADHVGDSLALSRVAAEAPEDTIVFCGVHFMAETAKILS
PHKTVLIPDQRAGCSLADSITPDELRAWKDEHPGAVVVSYVNTTAAVKAL
TDICCTSSNAVDVVASIDPDREVLFCPDQFLGAHVRRVTGRKNLHVWAGE
CHVHAGINGDELADQARAHPDAELFVHPECGCATSALYLAGEGAFPAERV
KILSTGGMLEAAHTTRARQVLVATEVGMLHQLRRAAPEVDFRAVNDRASC
KYMKMITPAALLRCLVEGADEVHVDPGIAASGRRSVQRMIEIGHPGGGE
>Rv1595 nadB, Probable L-aspartate oxidase nadB
MAGPAWRDAADVVVIGTGVAGLAAALAADRAGRSVVVLSKAAQTHVTATH
YAQGGIAVVLPDNDDSVDAHVADTLAAGAGLCDPDAVYSIVADGYRAVTD
LVGAGARLDESVPGRWALTREGGHSRRRIVHAGGDATGAEVQRALQDAAG
MLDIRTGHVALRVLHDGTAVTGLLVVRPDGCGIISAPSVILATGGLGHLY
SATTNPAGSTGDGIALGLWAGVAVSDLEFIQFHPTMLFAGRAGGRRPLIT
EAIRGEGAILVDRQGNSITAGVHPMGDLAPRDVVAAAIDARLKATGDPCV
YLDARGIEGFASRFPTVTASCRAAGIDPVRQPIPVVPGAHYSCGGIVTDV
YGQTELLGLYAAGEVARTGLHGANRLASNSLLEGLVVGGRAGKAAAAHAA
AAGRSRATSSATWPEPISYTALDRGDLQRAMSRDASMYRAAAGLHRLCDS
LSGAQVRDVACRRDFEDVALTLVAQSVTAAALARTESRGCHHRAEYPCTV
PEQARSIVVRGADDANAVCVQALVAVC
>Rv1596 nadC, Probable nicotinate-nucleotide pyrophosphatase nadC
MGLSDWELAAARAAIARGLDEDLRYGPDVTTLATVPASATTTASLVTREA
GVVAGLDVALLTLNEVLGTNGYRVLDRVEDGARVPPGEALMTLEAQTRGL
LTAERTMLNLVGHLSGIATATAAWVDAVRGTKAKIRDTRKTLPGLRALQK
YAVRTGGGVNHRLGLGDAALIKDNHVAAAGSVVDALRAVRNAAPDLPCEV
EVDSLEQLDAVLPEKPELILLDNFAVWQTQTAVQRRDSRAPTVMLESSGG
LSLQTAATYAETGVDYLAVGALTHSVRVLDIGLDM
>Rv2421c nadD, PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NICOTINATE MONONUCLEOTIDE
MGGTFDPIHYGHLVAASEVADLFDLDEVVFVPSGQPWQKGRQVSAAEHRY
LMTVIATASNPRFSVSRVDIDRGGPTYTKDTLADLHALHPDSELYFTTGA
DALASIMSWQGWEELFELARFVGVSRPGYELRNEHITSLLGQLAKDALTL
VEIPALAISSTDCRQRAEQSRPLWYLMPDGVVQYVSKCRLYCGACDAGAR
STTSLAAGNGL
>Rv0212c nadR, POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN NADR (PROBABLY ASNC-FAMILY)
MTHGMVLGKFMPPHAGHVYLCEFARRWVDELTIVVGSTAAEPIPGAQRVA
WMRELFPFDRVVHLANENPQRPWEHPDFWDIWKASLQGVLATRPDFVFGA
EPYNADFAQVLGARFVAVDHGRTVVPVTATDIRADPLGHWQHIPRCVRPA
FVKRVSIIGPESTGKTTLAQAVAEKLRTKWVPERAKMLRELNGGSLIGLE
WAEIVRGQIASEEALARDADRVLICDTDPLATTVWAEFLAGGCPQELRDL
ARRPYDLTLLTTPDVPWDADDGRCVPGARGTFFARCEQALRAAGRSFVVI
TGGWEERLSVSLRAVEELVRARR
>Rv0118c oxcA, PROBABLE OXALYL-CoA DECARBOXYLASE OXCA
MTTRSASPCTVLTDGCHLVVDALKANDVDTIYGVVGIPITDLARAAQASG
IRYIGFRHEASAGNAAAAAGFLTARPGVCLTTSGPGFLNGLPALANATTN
CFPMIQISGSSSRPMVDLQRGDYQDLDQLNAARPFVKAAYRIGQVQDIGR
GVARAIRTATSGRPGGVYLDIPGDVLGQAVEASAASGAIWRPVDPAPRLL
PAPEAIDRALDVLAQAQRPLLVLSKGAAYAQADNVIREFVEHTGIPFLPM
SMAKGLLPDSHPQSAAAARSLAMARADVVLLVGARLNWLLGNGESPQWSA
DAKFIQVDIEASEFDSNRPIVAPLTGDIGSVMSALLEAAADRSSVASAAW
TGELADRKARNSAKMRRRLADDHHPMRFYNALGAIRSVLQRNPDVYVVNE
GANALDLARNIIDMHLPRHRLDSGTWGVMGIGMGYAIAAAVETGRPVVAI
EGDSAFGFSGMEFETICRYRLPVTVVILNNGGVYRGDEATIFRSAAPVWR
HDPAPTVLNAHARHELIAEAFGGKGYHVSTPTELESALTDALASNGPSLI
DCELDPADGVESGHLAKLNTTSAATPAISGDG
>Rv1005c pabB, Probable para-aminobenzoate synthase component I PABD
MNLAWELSTRTKSPRSHLRCENPQFCQARTVRIDRLGDLGGAPAVLRAVG
RATSRLDLPPPAALTGEWFGALAVIAPSVSIQPVSGDDVFSGPPGTGGPD
ATGAVGGGWVGYLSYPDAGADGRPHRIPEAAGGWTDCVLRRDRDGQWWYE
SLSGAPIADWLASALATTRASVARPAPACRIDWEPADRAAHRDGVLACLE
AIGAGEVYQACVCTQFAGTVTGSPLDFFIDGFGRTAPSRSAFVAGPWGAV
ASLSPELFLRRRGSVVTSSPIKGTLPLDAPPSALRASAKEVAENIMIVDL
VRNDLGRVAVTGTVTVPELLVVRPAPGVWHLVSTVSARVPLEEPMSALLD
AAFPPASVTGTPKLRARQLISQWERYRRGIYCGTVGLASPVAGCELNVAI
RTVEFDTAGNAVLGVGGGITADSDPDAEWAECLHKAAPIVGLPAATRTTP
ARLASKVR
>Rv2225 panB, Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB
MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIF
DEAGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVA
DLPFGSYEAGPTAALAAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGI
PVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTIADAIAVAEAGAFAVVMEM
VPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSGAKTARFVKR
YADVGGELRRAAMQYAQEVAGGVFPADEHSF
>Rv3602c panC, PROBABLE PANTOATE--BETA-ALANINE LIGASE PANC (PANTOTHENATE SYNTHETASE) (PANTOATE ACTIVATING ENZYME)
MTIPAFHPGELNVYSAPGDVADVSRALRLTGRRVMLVPTMGALHEGHLAL
VRAAKRVPGSVVVVSIFVNPMQFGAGEDLDAYPRTPDDDLAQLRAEGVEI
AFTPTTAAMYPDGLRTTVQPGPLAAELEGGPRPTHFAGVLTVVLKLLQIV
RPDRVFFGEKDYQQLVLIRQLVADFNLDVAVVGVPTVREADGLAMSSRNR
YLDPAQRAAAVALSAALTAAAHAATAGAQAALDAARAVLDAAPGVAVDYL
ELRDIGLGPMPLNGSGRLLVAARLGTTRLLDNIAIEIGTFAGTDRPDGYR
AILESHWRN
>Rv3601c panD, PROBABLE ASPARTATE 1-DECARBOXYLASE PRECURSOR PAND (ASPARTATE ALPHA-DECARBOXYLASE)
MLRTMLKSKIHRATVTCADLHYVGSVTIDADLMDAADLLEGEQVTIVDID
NGARLVTYAITGERGSGVIGINGAAAHLVHPGDLVILIAYATMDDARART
YQPRIVFVDAYNKPIDMGHDPAFVPENAGELLDPRLGVG
>Rv0853c pdc, PROBABLE PYRUVATE OR INDOLE-3-PYRUVATE DECARBOXYLASE PDC
MTPQKSDACSDPVYTVGDYLLDRLAELGVSEIFGVPGDYNLQFLDHIVAH
PTIRWVGSANELNAGYAADGYGRLRGMSAVVTTFGVGELSVTNAIAGSYA
EHVPVVHIVGGPTKDAQGTRRALHHSLGDGDFEHFLRISREITCAQANLM
PATAGREIDRVLSEVREQKRPGYILLSSDVARFPTEPPAAPLPRYPGGTS
PRALSLFTKAAIELIADHQLTVLADLLVHRLQAVKELEALLAADVVPHAT
LMWGKSLLDESSPNFLGIYAGAASAERVRAAIEGAPVLVTAGVVFTDMVS
GFFSQRIDPARTIDIGQYQSSVADQVFAPLEMSAALQALATILTGRGISS
PPVVPPPAEPPPAMPARDEPLTQQMVWDRVCSALTPGNVVLADQGTSFYG
MADHRLPQGVTFIGQPLWGSIGYTLPAAVGAAVAHPDRRTVLLIGDGAAQ
LTVQELGTFSREGLSPVIVVVNNDGYTVERAIHGETAPYNDIVSWNWTEL
PSALGVTNHLAFRAQTYGQLDDALTVAAARRDRMVLVEVVLPRLEIPRLL
GQLVGSMAPQ
>Rv2607 pdxH, PROBABLE PYRIDOXAMINE 5'-PHOSPHATE OXIDASE PDXH (PNP/PMP OXIDASE) (PYRIDOXINEPHOSPHATE OXIDASE) (PNPOX) (PYRIDOXINE 5'-PHOSPHATE OXIDASE)
MDDDAQMVAIDKDQLARMRGEYGPEKDGCGDLDFDWLDDGWLTLLRRWLN
DAQRAGVSEPNAMVLATVADGKPVTRSVLCKILDESGVAFFTSYTSAKGE
QLAVTPYASATFPWYQLGRQAHVQGPVSKVSTEEIFTYWSMRPRGAQLGA
WASQQSRPVGSRAQLDNQLAEVTRRFADQDQIPVPPGWGGYRIAPEIVEF
WQGRENRMHNRIRVANGRLERLQP
>Rv1940 ribA1, Probable Riboflavin biosynthesis protein ribA1 (GTP cyclohydrolase II)
MKTTDVRVRRAITAMAGGHAVVLTGDPNGDGYLVFAAQAATPRLVAFAVR
HTSGYLRVALPGAECERLHLPPMCDRDTTHCVSVDVRGTGTGISASDRAW
TIAALASATSVAADFQRPGHVVPVQAQADGVLGRRGPAEAAVDLARLAER
RPAAALCEIVSPDNPVQMAHHAESVEFAVEHGLAMVSIGELVAYRRRIEP
QVVRFTAATLPTWAGASRVIGFRDVYDLGEHLAVIVGAVGAGVPVPLHVH
IECLTGDVFGSTACRCGEELNGALARMSAQGSGVVLYLRPPGPAQACGLF
ARGDAATDVMPETVTWILRDLGVYAIRLSDDVPGFGLVMFGAIREASTLA
AAG
>Rv1415 ribA2, PROBABLE RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBA2 : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase)
MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEKATPEMVAFMV
RYTSGYLCVPLDGAICDRLGLLPMYAVNQDKHGTAYTVTVDARNGIGTGI
SASDRATTMRLLADPTSVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVD
LARMAGLQPAGAICEIVSQKDEGSMAHTDELRVFADEHGLALITIADLIE
WRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYEDVEHVALVRGEIAGPN
ADGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAALAMVAREGRGVVLYMR
GHEGRGIGLMHKLQAYQLQDAGADTVDANLKLGLPADARDYGIGAQILVD
LGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANAENIRYLMTKRDK
LGHDLAGLDDFHESVHLPGEFGGAL
>Rv1412 ribC, PROBABLE RIBOFLAVIN SYNTHASE ALPHA CHAIN RIBC (RIBE)
MFTGIVEERGEVTGREALVDAARLTIRGPMVTADAGHGDSIAVNGVCLTV
VDVLPDGQFTADVMAETLNRSNLGELRPGSRVNLERAAALGSRLGGHIVQ
GHVDATGEIVARCPSEHWEVVRIEMPASVARYVVEKGSITVDGISLTVSG
LGAEQRDWFEVSLIPTTRELTTLGSAAVGTRVNLEVDVVAKYVERLMRSA
G
>Rv2671 ribD, POSSIBLE BIFUNCTIONAL ENZYME RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD: DIAMINOHYDROXYPHOSPHORIBOSYLAMINOPYRIMIDINE DEAMINASE (RIBOFLAVIN-SPECIFIC DEAMINAS
MPDSGQLGAADTPLRLLSSVHYLTDGELPQLYDYPDDGTWLRANFISSLD
GGATVDGTSGAMAGPGDRFVFNLLRELADVIVVGVGTVRIEGYSGVRMGV
VQRQHRQARGQSEVPQLAIVTRSGRLDRDMAVFTRTEMAPLVLTTTAVAD
DTRQRLAGLAEVIACSGDDPGTVDEAVLVSQLAARGLRRILTEGGPTLLG
TFVERDVLDELCLTIAPYVVGGLARRIVTGPGQVLTRMRCAHVLTDDSGY
LYTRYVKT
>Rv2786c ribF, PROBABLE BIFUNCTIONAL FAD SYNTHETASE/RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBF: RIBOFLAVIN KINASE (FLAVOKINASE) + FMN ADENYLYLTRANSFERASE (FAD PYROPHOSPHOR
MRRRLAIVQRWRGQDEIPTDWGRCVLTIGVFDGVHRGHAELIAHAVKAGR
ARGVPAVLMTFDPHPMEVVYPGSHPAQLTTLTRRAELVQDLGIEVFLVMP
FTTDFMKLTPDRFIHELLVEHLHVVEVVVGENFTFGKKAAGNVDTLRRAG
ERFGFAVESMSLVSEHHSNETVTFSSTYIRSCVDAGDMVAAMEALGRPHR
VEGVVVRGEGRGAELGFPTANVAPPMYSAIPADGVYAAWFTVLGHGPVTG
TVVPGERYQAAVSVGTNPTFSGRTRTVEAFVLDTTADLYGQHVALDFVGR
IRGQKKFESVRQLVAAMGADTERARDLLSTG
>Rv1409 ribG, PROBABLE BIFUNCTIONAL riboflavin biosynthesis protein RIBG : Diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5
MNVEQVKSIDEAMGLAIEHSYQVKGTTYPKPPVGAVIVDPNGRIVGAGGT
EPAGGDHAEVVALRRAGGLAAGAIVVVTMEPCNHYGKTPPCVNALIEARV
GTVVYAVADPNGIAGGGAGRLSAAGLQVRSGVLAEQVAAGPLREWLHKQR
TGLPHVTWKYATSIDGRSAAADGSSQWISSEAARLDLHRRRAIADAILVG
TGTVLADDPALTARLADGSLAPQQPLRVVVGKRDIPPEARVLNDEARTMM
IRTHEPMEVLRALSDRTDVLLEGGPTLAGAFLRAGAINRILAYVAPILLG
GPVTAVDDVGVSNITNALRWQFDSVEKVGPDLLLSLVAR
>Rv1416 ribH, PROBABLE RIBOFLAVIN SYNTHASE BETA CHAIN RIBH (6,7-dimethyl-8-ribityllumazine synthase) (DMRL synthase) (Lumazine synthase)
MPDLPSLDASGVRLAIVASSWHGKICDALLDGARKVAAGCGLDDPTVVRV
LGAIEIPVVAQELARNHDAVVALGVVIRGQTPHFDYVCDAVTQGLTRVSL
DSSTPIANGVLTTNTEEQALDRAGLPTSAEDKGAQATVAALATALTLREL
RAHS
>Rv3248c sahH, PROBABLE ADENOSYLHOMOCYSTEINASE SAHH (S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE) (ADOHCYASE)
MTGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLR
REYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQD
HAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPA
NMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFET
DKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSK
FDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGAR
VSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIK
AMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSII
VLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLP
KHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY
>Rv2996c serA1, PROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH)
MSLPVVLIADKLAPSTVAALGDQVEVRWVDGPDRDKLLAAVPEADALLVR
SATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIH
SAAEHALALLLAASRQIPAADASLREHTWKRSSFSGTEIFGKTVGVVGLG
RIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFIS
VHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHV
RAAGLDVFATEPCTDSPLFELAQVVVTPHLGASTAEAQDRAGTDVAESVR
LALAGEFVPDAVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSDELPVSLSV
QVRGELAAEEVEVLRLSALRGLFSAVIEDAVTFVNAPALAAERGVTAEIC
KASESPNHRSVVDVRAVGADGSVVTVSGTLYGPQLSQKIVQINGRHFDLR
AQGINLIIHYVDRPGALGKIGTLLGTAGVNIQAAQLSEDAEGPGATILLR
LDQDVPDDVRTAIAAAVDAYKLEVVDLS
>Rv0728c serA2, POSSIBLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA2 (PHOSPHOGLYCERATE DEHYDROGENASE) (PGDH)
MTPRPRALVTAPLRGPGFAQLRRLADVVYDPWIDQRPLRIYSAEQLADRI
TAVAADVLVVESDSVGGPVFERGLRVVAATRGDPSNVDIPGATAAGIPVL
HTPARNADAVAEMTVALLLAVARHLIPADADVRSGNIFRDGTIPYQRFRG
AEIAGLTAGLVGLGAVGRAVRWRLSGLGLRVIAHDPYRDDAGHSLDELLA
EADIVSMHAAVTDDTIGMIGAQQFAAMRDGAVFLNTARSQLRDTDALVDA
LRGGKLAAAGLDHFTGEWLPTDHPLVSMPNVVLTPHIGGATWNTEARQAR
MVADDLGALLSGNRPAHVVNPEVLGS
>Rv0884c serC, POSSIBLE PHOSPHOSERINE AMINOTRANSFERASE SERC (PSAT)
MADQLTPHLEIPTAIKPRDGRFGSGPSKVRLEQLQTLTTTAAALFGTSHR
QAPVKNLVGRVRSGLAELFSLPDGYEVILGNGGATAFWDAAAFGLIDKRS
LHLTYGEFSAKFASAVSKNPFVGEPIIITSDPGSAPEPQTDPSVDVIAWA
HNETSTGVAVAVRRPEGSDDALVVIDATSGAGGLPVDIAETDAYYFAPQK
NFASDGGLWLAIMSPAALSRIEAIAATGRWVPDFLSLPIAVENSLKNQTY
NTPAIATLALLAEQIDWLVGNGGLDWAVKRTADSSQRLYSWAQERPYTTP
FVTDPGLRSQVVGTIDFVDDVDAGTVAKILRANGIVDTEPYRKLGRNQLR
VAMFPAVEPDDVSALTECVDWVVERL
>Rv0423c thiC, PROBABLE THIAMINE BIOSYNTHESIS PROTEIN THIC
MTITVEPSVTTGPIAGSAKAYREIEAPGSGATLQVPFRRVHLSTGDHFDL
YDTSGPYTDTDTVIDLTAGLPHRPGVVRDRGTQLQRARAGEITAEMAFIA
AREDMSAELVRDEVARGRAVIPANHHHPESEPMIIGKAFAVKVNANIGNS
AVTSSIAEEVDKMVWATRWGADTIMDLSTGKNIHETREWILRNSPVPVGT
VPIYQALEKVKGDPTELTWEIYRDTVIEQCEQGVDYMTVHAGVLLRYVPL
TAKRVTGIVSRGGSIMAAWCLAHHRESFLYTNFEELCDIFARYDVTFSLG
DGLRPGSIADANDAAQFAELRTLGELTKIAKAHGAQVMIEGPGHIPMHKI
VENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQAGTAML
CYVTPKEHLGLPDRKDVKDGVIAYKIAAHAADLAKGHPRAQERDDALSTA
RFEFRWNDQFALSLDPDTAREFHDETLPAEPAKTAHFCSMCGPKFCSMRI
TQDVREYAAEHGLETEADIEAVLAAGMAEKSREFAEHGNRVYLPITQ
>Rv0422c thiD, PROBABLE PHOSPHOMETHYLPYRIMIDINE KINASE THID (HMP-PHOSPHATE KINASE) (HMP-P KINASE)
MTPPRVLSIAGSDSGGGAGIQADMRTMALLGVHACVAVTAVTVQNTLGVK
DIHEVPNDVVAGQIEAVVTDIGVQAAKTGMLASSRIVATVAATWRRLELS
VPLVVDPVCASMHGDPLLAPSALDSLRGQLFPLATLLTPNLDEARLLVDI
EVVDAESQRAAAKALHALGPQWVLVKGGHLRSSDGSCDLLYDGVSCYQFD
AQRLPTGDDHGGGDTLATAIAAALAHGFTVPDAVDFGKRWVTECLRAAYP
LGRGHGPVSPLFRLS
>Rv0414c thiE, PROBABLE THIAMINE-PHOSPHATE PYROPHOSPHORYLASE THIE (TMP PYROPHOSPHORYLASE) (TMP-PPASE) (THIAMINE-PHOSPHATE SYNTHASE)
MHESRLASARLYLCTDARRERGDLAQFAEAALAGGVDIIQLRDKGSPGEL
RFGPLQARDELAACEILADAAHRYGALFAVNDRADIARAAGADVLHLGQR
DLPVNVARQILAPDTLIGRSTHDPDQVAAAAAGDADYFCVGPCWPTPTKP
GRAAPGLGLVRVAAELGGDDKPWFAIGGINAQRLPAVLDAGARRIVVVRA
ITSADDPRAAAEQLRSALTAAN
>Rv0417 thiG, PROBABLE THIAMIN BIOSYNTHESIS PROTEIN THIG (THIAZOLE BIOSYNTHESIS PROTEIN)
MAESKLVIGDRSFASRLIMGTGGATNLAVLEQALIASGTELTTVAIRRVD
ADGGTGLLDLLNRLGITPLPNTAGSRSAAEAVLTAQLAREALNTNWVKLE
VIADERTLWPDAVELVRAAEQLVDDGFVVLPYTTDDPVLARRLEDTGCAA
VMPLGSPIGTGLGIANPHNIEMIVAGARVPVVLDAGIGTASDAALAMELG
CDAVLLASAVTRAADPPAMAAAMAAAVTAGYLARCAGRIPKRFWAQASSP
AR
>Rv2977c thiL, PROBABLE THIAMINE-MONOPHOSPHATE KINASE THIL (THIAMINE-PHOSPHATE KINASE)
MTTKDHSLATESPTLQQLGEFAVIDRLVRGRRQPATVLLGPGDDAALVSA
GDGRTVVSTDMLVQDSHFRLDWSTPQDVGRKAIAQNAADIEAMGARATAF
VVGFGAPAETPAAQASALVDGMWEEAGRIGAGIVGGDLVSCRQWVVSVTA
IGDLDGRAPVLRSGAKAGSVLAVVGELGRSAAGYALWCNGIEDFAELRRR
HLVPQPPYGHGAAAAAVGAQAMIDVSDGLLADLRHIAEASGVRIDLSAAA
LAADRDALTAAATALGTDPWPWVLSGGEDHALVACFVGPVPAGWRTIGRV
LDGPARVLVDGEEWTGYAGWQSFGEPDNQGSLG
>Rv0416 thiS, POSSIBLE PROTEIN THIS
MIVVVNEQQVEVDEQTTIAALLDSLGFGDRGIAVALNFSVLPRSDWATKI
CELRKPVRLEVVTAVQGG
>Rv1609 trpE, Probable anthranilate synthase component I trpE (GLUTAMINE AMIDOTRANSFERASE)
MHADLAATTSREDFRLLAAEHRVVPVTRKVLADSETPLSAYRKLAANRPG
TFLLESAENGRSWSRWSFIGAGAPTALTVREGQAVWLGAVPKDAPTGGDP
LRALQVTLELLATADRQSEPGLPPLSGGMVGFFAYDMVRRLERLPERAVD
DLCLPDMLLLLATDVAAVDHHEGTITLIANAVNWNGTDERVDWAYDDAVA
RLDVMTAALGQPLPSTVATFSRPEPRHRAQRTVEEYGAIVEYLVDQIAAG
EAFQVVPSQRFEMDTDVDPIDVYRILRVTNPSPYMYLLQVPNSDGAVDFS
IVGSSPEALVTVHEGWATTHPIAGTRWRGRTDDEDVLLEKELLADDKERA
EHLMLVDLGRNDLGRVCTPGTVRVEDYSHIERYSHVMHLVSTVTGKLGEG
RTALDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVVGYLDFAG
NADFAIAIRTALMRNGTAYVQAGGGVVADSNGSYEYNEARNKARAVLNAI
AAAETLAAPGANRSGC
>Rv0013 trpG, POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE AMIDOTRANSFERASE)
MRILVVDNYDSFVFNLVQYLGQLGIEAEVWRNDDHRLSDEAAVAGQFDGV
LLSPGPGTPERAGASVSIVHACAAAHTPLLGVCLGHQAIGVAFGATVDRA
PELLHGKTSSVFHTNVGVLQGLPDPFTATRYHSLTILPKSLPAVLRVTAR
TSSGVIMAVQHTGLPIHGVQFHPESILTEGGHRILANWLTCCGWTQDDTL
VRRLENEVLTAISPHFPTSTASAGEATGRTSA