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# Prochlorococcus marinus subsp. marinus str. CCMP1375, CCMP1375; SS120

>Pro0815 B-12 Dependent Ribonucleotide Reductase
MLALAMALACVILTDIKILSLAASKQKIERNSSIDPDVTQAFPATAPAAN
PVFYRTYSRKTPSGRESWEQVSSRNLQGLLRLGSLTNEEVALMAQMQTEK
KALPSGRWLWIGGTDWINKEKNFSGAYNCTSTNLVDWEAFGLMMDLAMMG
CGTGAIIEPHLINKLPIILNPINIKSVSEIGITEAENRKEKTSSTVKGNN
VLIKVGDSRRGWVDSYQALLQISSDPQFKGETVEVTIDLNDVRPAGESLK
GFGGMANPVKLKDLYPRVAGILSRGLGRQLTSVECCLLIDEAAVTIVAGN
IRRSAGMRQFSSNDSLATSAKENLWEQDSDGNWRIDPERDALRMANHTRV
YHTRPTLKEINDAVVKQFHSGEGAIQFAPEAIARSNADILTTKELREEFI
EIYCEQGRVEASKWLQDNYGPINSAEMEHRLGRYGLNPCGEILGADFHCN
LAEVHLNQISPSDKEGQEKAFKAAGLSVACLLNHRFEVDRYRESRALDPI
VGVSFTGLFDFFVHAFGTPWLKWWEKGRPNSEQGESFKKQEADYLKRWKN
IVNQTVWDYCDKHNLRRPNRCTTVQPAGTKSLLTGAAPGWHPPKAQRFIR
RITFRKSDPVAMACMDYGYTIVPSQSDKDENGRLLDNPFDPRCTEWLVEI
PTEVSWANIPGADEIEINNFSALAQFDFYMQVQSHYTDHNTSATIEFREN
EIGPLSEAIYNSIKANKGYISAALLARFDANATFPRLPFEPIDSKTYERL
QSEVIQRRVSNDFFEALSLYDQGELTEAGPAGCDSDKCLLPLAKPQK
>Pro1210 Nucleoside 2-deoxyribosyltransferase
MTRKIIYLASPYGFSKQCKKNLLPEFIAALEDLGAEVWEPFSRNAQYENL
QPGWAHDIALADLRDVRNSDGILAVVNGTPPDEGVMIELGAAIALGKPTF
LFRDDFRRCSDSEEYPLNLMLFAGLPSIGWNDYFYTSIEELSDPKKSLAI
WLKD
>Pro0549 Xanthosine triphosphate pyrophosphatase
MTAPLLTIASGNPKKVSEIESMLGPLPIGVKRQPEGLSIEETGSSYLENA
LLKAQTTAKLTNTWAIADDSGLEVDALNGAPGIYSARFAINNEEKLKKLL
GELKNNPYRSARFCSVMVLCDPQGNHIHDSEGICWGEILKKPAYPEGEFE
SIFWVREANCTYGQLSQEQLTRLGSRGKAARAMSPYLLKALNLN
>Pro0463 Predicted protein
MFEFIVGSHEFLGNHTFAEFLVGYIFGAALIIGAPTVFLLLAFISALMKT
NGKMGGYKEYETYGASTLNECPPFILPDPTNPKSKSSNNRQNTSKRGRFA
>Pro0311 Xanthosine triphosphate pyrophosphatase
MSFNLGKSLTKLIIASNNDGKIEEFIQLLSGIPLVVMGQPKHLEVEETGV
SFAENARIKAIAVAKATGEMALADDSGLSVGSLGGAPGVFSARYANTDLE
RVSRLLKELEMVDDRSAFFSAALCLASSKGEVLLELDGRCDGIITTTPRG
KFGFGYDPIFEVKGTGLTFSEMDSKQKRELSHRGLAVKKLIPSLKKILDS
>Pro0898 Predicted protein
MSNYSNEQPEPILTFDGKRYNINNLPNELKEIVKGLQISDNQLRLYEDTL
KVLAIGRQSLAKQLNEKLKDIDPIP
>Pro0915 Predicted protein
MVKKRRKLSKEYETIVSKAQKEIELILAKINDIDDDDIRVEYAVAFAPSK
NLLDKINLQYKEVGYTADSEEILSNYYTRLEKFKNEYEI
>Pro0961 APA2, ATP adenylyltransferase
MNQENYWIKSLSLSKNALENSSLKPINTNLEYLSTATNLIFEYRRVSSIN
FKFSTTFGPKENPFRPWDKRLQIDTIGNNHILILNKYPVQIGHMLLITRK
WYPQDGWLNQTDWEALKAVEKDTSGLWFFNSGPKAGASQNHRHLQLLRRK
ILDISCPLESWYEGNQNINLCESSLLRRNICSAKRSIKNETAYDLHNTYI
RLCDRIGLGAPDDSTKPNYPYNLLISPNWIGIIRRSKEYAYGFSLNALAF
AGYLLGTNKSNNDWLNKNGPIKLLEEVVAD
>Pro0273 THY1, Predicted alternative thymidylate synthase
MNNVHLVTATPDAEKTMAYIARVSNPKNQANEEFGKLIKYCINNEHWSVF
EQAYMTLQIETNRAIAAQILRHRSFTFQEFSQRYADSTQLGEIPIPELRR
QDSKNRQNSTSDLDEDIANDFREKIKLQFKNSLDLYQEMLDKGVAKESAR
FILPLATPTRIYMTGSCRSWLHYINLRSGHGTQKEHLIIAKECKKIFTLQ
FPKVSEALGWIES
>Pro1693 adk, Adenylate kinase
MKNRLLFLGPPGAGKGTQASLICKDQGFLHLSTGDLLREEVSGGTDLGKK
AELIMNKGELVSDEIVISIVEKRLIKYSEGWLLDGFPRNLAQASLLQNLL
GRISQPIEIVLLIEIDDEILTERMLGRGRKDDNKAVIKNRLKIYKDQTSP
LVDHYKKQGILKSINGCGSVEDVNSRIKEALS
>Pro1445 apt, Adenine/guanine phosphoribosyltransferases
MIGSKLKEAIRSYSDFPKKGILFHDISPIFCKPDLYQELIEEMAKSEILN
SSDAIISIDARGFLFGSCISLKLSKPLILARKAGKLPGPILSSTYNLEYG
ENSLSIQKESLNEFKNFAIIDDVLATGGTINCVKSLLTSHNKNISGACVV
IELLALKAREKLDFPIYSTLTL
>Pro0745 carA, Carbamoylphosphate synthase small subunit
MSIFSGNDNAILVLSDGTFIEGKAFGFRGTVSGEIVFNTGITGYQEVLTD
PSYFGQLITFTFPELGNTGVNPEDQESDSPSAKGVIARQVSCYASNWRST
KTFEQWLKDEKVVGICDVDTRALVRHLRSSGTMNAIISSENNASPSSLLN
TIRQAPQMKGLNLTGEVTTKKPYKWNSLASVDFDERVVNQAMSPFNVVAI
DFGIKRSILNRLVAHGCEVNVLPANTSFSEVMSFNPEGVFFSNGPGDPSS
VKEGMSLAKRLIEEVDVPMFGICLGHQILGLALGGKTFKLAYGHRGLNHP
CGKTGRIEITSQNHGFALDALSLDKDVVEITHLNLNDGTVAGIAMCNRPI
FGIQYHPEASPGPHDADHHFSRFVDLMSERR
>Pro0897 carB, Carbamoylphosphate synthase large subunit
MPRRNDIRRILILGSGPIVIGQACEFDYSGTQACKALKKEGFEVVLINSN
PASIMTDPEMADRTYIEPLTTEVITKIIELEKPDALLPTMGGQTALNAAV
DLAEKGILRKFKIELIGADLESINKAEDRQLFKNSMEKIGVNVCPSGIAC
NIEEAINVGSNIESFPRIIRPAFTLGGSGGGIAYNQEEFISICKSGLEAS
PASQILIEKSLLGWKEFELEVMRDNVDNVVIICSIENIDPMGIHTGDSIT
IAPAQTLTDREYQRLRDQSIKIIREIGVETGGSNVQFAVNPVDGEVVVIE
MNPRVSRSSALASKATGFPIAKIAALLAIGYRLDEILNDITGKTPCCFEP
TIDYIVTKIPRFAFEKFSGSPPILTTSMKSVGEVMAIGRSFEESFQKALR
SLEIGLSGWSYDCENINISLKDIDRLLRVPSPDRLMAIKMAMYHGKSDQY
INSLSNIDIWFLSKLRNIMEAENNKLLGKTILDLDYDSMFELKKLGFSDS
QIGFLVGEDELRVRSFRKDLNIKPVYKTVDTCSSEFESNTPYHYSTYERT
FKEIIKDGSLINKSSANEVIQNQYRKILILGGGPNRIGQGIEFDYCCCHS
SFQLQKEGFQTIMLNSNPETVSTDYDTSDSLYFEPLTFEDVLNVIELENP
EGIIVQFGGQTPLKLAMPILNWLDTKEGKMSGSKIFGTSPKSIDQAEDRE
QFEHILRELRVRQPSNGIARSISEAEKIANRISYPLVVRPSYVLGGRAME
IVYDSQELKTYMNKAVKVEPDHPVLIDEYLENAIEVDVDALSDSFGNVVI
AGLMEHIEPAGIHSGDSACCLPSISLSDSSIKTIKEWTNSLAKSLNVIGL
INLQFAVQRDDNGEEKVFIIEANPRASRTIPFVSKAIGWPLARLATSLLI
GKTLHQIGILNEPVPPLQTIKEAVMPFRRFPGSDSVLGPEMRSTGEVMSS
AKNFGMAYAKSELAAGEALPTKGIVFLSTHNRDKPALIPIARRLVDLGFG
LIATSGTAEVISNAGIDVSSVLKVHEGRPNIEDVIRSGQIQLIINTPIGR
QAIYDDKYLRRAALDYSVPTLTTLAGARAAVEGICALQNEPISVTALQDI
HSLVTFHG
>Pro1036 cumB, Cytosine/adenosine deaminase
MQFTKPVKLNDTQIHRWMMILRKRAKIVGKEGEVPITAIILNEKGHCIGH
GRNTRNKRFDPMGHAELVALRQAAWLKGDWRFNECTLIVTLEPCQMCAGA
LIQARMGRVIFGAYDFKRGGLGGTLDLSTHKSAHHKMIVKGGVMKKEIKQ
EIEEWFSLRRLIKL
>Pro0274 dcd, Deoxycytidine deaminase
MLKNDRWIIKQSEAGMLQPFQPNLVRHLDPQIKEKPVLSFGCSSYGYDLR
LSSKEFLIFRHVPGTIMNPKKFNPDNLEATPLHHDEDGDYFILPAHSYGL
GVALEKMKVPPNITVICLGKSTYARLGIIVNTTPAEASWEGHLTLEFSNS
SGADCRIYANEGICQLLFFEGDPCGTTYRDRKGKYQDQPEKVTLAKV
>Pro0396 deoC, Deoxyribose-phosphate aldolase
MQYKSNNLEISEINSFIHQAALDPHINLDSLNQICDVCKHFNFAGLCTNL
IRIQAARKSLGKNKQTKLIAVIAFPFGDIPNSIKKTEAELAAEHGAEELD
IVPNYLKLYEGKIDSFAEELAEIFKIGLPYRVILDSIRIPEEKLSLAIEA
SIDAGARGIQAGNGFGTPIQASHILKLRALIKNRCELKVAGGIKNLHQVL
ELVEAGASSIGTSVGADLAKQFKIYNHQN
>Pro0465 gmk, Guanylate kinase
MTNYNGLIVITGPSGVGKGTLVKKLLLENPEIWLSISATTRTPREGEING
KDYFFLNKKEFIDLVDKEGFLEWAEFAGNFYGTPRAQAQEKISVGKKVLL
EIELDGARQVRKTFPEGFQIFIAPPSFEELEKRIRTRGTDSELAIQSRLN
RAKEELLAKNEFDAIVINDQLDIALLEIKKLIKS
>Pro0456 gppA, Exopolyphosphatase
MGLVVSKSPVEITGEESISTSHAEIYQSKDSRFRNNEKIRRVAAVDIGTN
SIHLVIASVDPSLNTFSIDLAEKSSTRLGNRDPENGDLTESAKERTIETL
KRFKDLAFSHKVDEILLAATSAVREAPNGAGFLQQINANLGLEVELVSGP
EEARLIYLGVLSGMPFGETPHILLDIGGGSTELVLADGQDARALTSTRLG
AVSLQRDFVKEEPISSQRLEFLKTFIQGSLEPAINKVCSRINEGEKTALV
ATSGTALAIGTLAASEQQNFEFRKHGYKFTKEQLDKLIEKLLIMTPDQRR
KLPSISDRRAEIIVPGALIMQVAMQMLDIEEVILSERALREGLVVDWMFR
KGLLKDRFSFQGSIRERTVIHQLERFSVNRQRAERVAANALDIYDNTHGA
LHHDEGDGRDLLWAAALLHSCGQHINLASFHKHSWYLIRHGELLGYSQAE
HLMVAAIARYHRKSLPKKRHEAWQSLFNKEHRRIVSEMSLILRLSAALDR
RPEPAIASLRVACSSSEIIFYLVPEGTKQNLALEIWSLSNCIPIVKSLTG
FDLKVLVD
>Pro0038 guaA, GMP synthase
MSDPKVTTQRNPSIVILDFGSQYSELIARRIRETEVYSMVLGYNSSVEEL
KKLSPQGIILSGGPSSVYEEKAPLCDPSIWDLDIPILGVCYGMQVMVKQL
GGLVGEAIGKAEYGKALLQVDDPTALLTNVENGSTMWMSHGDSVKQLPAG
FVRLAHTTNTPDAAIACHDRRFYGVQFHPEVVHSTDGMVIIRNFVHNICR
SKPDWTTNTFIDEAINDVQEKVGKKRVLLALSGGVDSSTLAFLLKKAIGN
QLTCMFIDQGFMRKGEPEFLMEFFDKKFHINVEYINARDRFLDKLQGVSD
PEKKRKIIGTEFIRVFEEESLRLGPFDYLAQGTLYPDVIESSGTNIDPKT
GERIAVKIKSHHNVGGLPKDLQFKLVEPLRTLFKDEVRKVGRSLGLPEEI
VNRHPFPGPGLAIRILGEVTKEKLNCLRDADLIVREEIADAGLYHQIWQA
FAVLLPVRSVGVMGDQRTYAWPIVLRCVSSEDGMTADWSRLPNSLLEKIS
NRIVNEVNGVNRVVLDITSKPPGTIEWE
>Pro1451 guaA, GMP synthase-Glutamine amidotransferase domain
MFRLVVLQHLGREGPGLFAKVALQRGMNVIICRLDLGDAVPDLLEEDVLL
ILGGPMGLRDMNNDNYPWLLKEISLLQVALQKKIPVIGVCLGAQLLAYAA
GGKVERLTLGKNKKEGLEVGWGSIYFINANNPFNFSGDLRPKVLHWHGDR
IILPEGAQLIASSDICAEQFFCIPPCSYGIQFHVEIEEHIFSQWISEDKE
FIQKAFGDKASTILKQQQKKFGAQTLNHRINFIDKLYEVLEL
>Pro1138 guaB, IMP dehydrogenase/GMP reductase
MNIQLGHSKFVRRAYGIDEIALVPGGKTVDPENTDTTLLIGGKSLEIPII
ASAMDGVVDVNMAVALSKLGSLGVLNLEGVQTRYEKPNDVLKRISSVGKE
EFVPLMQEIYKQPIKENLINQRIQEIKDQGGLAAVSGTPLAAIKFKDTIT
KAKPDLFFLQATVVSTEHIGGGKQEKLEISNLCQTLGIPVIVGNCVTYEV
ALNLMRAGVSGILVGIGPGAACTSRGVLGVGVPQATAISDCSAARDDYKK
ETGNHVPVIADGGIITGGDVCKCIACGADGVMIGSPIARASEAPGNGYHW
GMATPSPVLPRGTRIKVGSTGNLMQILRGPAKTDDGTHNLLGALKTSMGT
LGAQTIKEMQEVEIVIAPSLLSEGKVYQKAQQLGMGK
>Pro0080 hit, HIT family hydrolase
MSEETIFSRILRGEIDCDEIYSDEMCLAFRDIQPQAPVHILVIPRKAIPS
LREAEIQDESLLGHLLLVSAKIAKLEGLNHWRTVINSGSEAGQTVFHLHI
HVIGGRKLNWPPG
>Pro0385 miaE, Probable hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA
MKVLRAKEKSFSQIKWLLTSTSKSWLEQALSNPIEVLIDHANCERKAAGV
AIQMMFRYLSEPGLAEVLSPLAREELDHFEKVLEILKSKGRYLEPLAAPP
YGALLTKNVRKEEPLRMLDSFLVAGLIEARSHERMSLLALHSLDKDIKDL
YADLLESEARHFGVYWKLAEKRFEKSLILSRMKELAEIESNILSELYCQP
RMHS
>Pro0050 ndk, Nucleoside diphosphate kinase
MPRGYIPEDDISILNLFGFMSVERTFLAIKPDGVQRGLVGEILGRFERKG
FKLVGLKQLIPSKELAEKHYGVHKERPFFTGLVGFITSGPVVAMVWEGDG
VILSARKLIGATKPLEAEPGTIRGDLGINIGRNVIHGSDGPETASFEIDL
WFNSSELNNWNPSDQKWRVE
>Pro0332 pnp, Purine nucleoside phosphorylase
MINKHFSSEEIEQDGKSCLLKNARLGVLGGSGLYSIDSIENIKELDIETP
YGKPSDSLRIGNLGGMEVVFLARHGRHHIYTPTEIPYRANIWALRSLNVR
WILSPSAVGSLQEQVRPLDMVVPDQFIDRTHQRPLTFFCDGAVAHVTMAD
PFCPTLSRLLAEEGELLMPEARQVHKGGTYLAMEGPAFSTRAESQLYRSW
GCKVIGMTNHTEARLAREAEIAYTSLSMVTDYDCWHEGFGNVSVDLVIEN
LAANAKLASKIVEATAKRISKLLPPSEAHTALKNSLMTSKDKVSETTREK
INLFTENYWGKFNK
>Pro1118 prsA, Phosphoribosylpyrophosphate synthetase
MTAATAQNIKSSLNTDRLKLISGTSNPILAKEISSYIGIEDVPVVSKRFA
DGELYVQIQQSIRGCDVFLIQPTCAPVNDSLMELMIMVDACKRASARQVT
AVIPYFGYARADRKTAGRESITAKLTANLLVSSGVDRVLAMDLHSAQIQG
YFDIPCDHIYGSPVLIDYLSTKNLDEIVVVSPDVGGVARARAFAKQMKDS
PLAIIDKRRAAHNVAQSLTVIGDVANKTAILIDDMIDTGGTICAGAELLR
KEGAKRVIACASHAVFSPPAYSRLSADDLFEEVVVTNSIPVPTSQYFEQL
KVLSVANMLGEAIWRVHEESSISSMFR
>Pro0506 purA, Adenylosuccinate synthase
MANVVVIGAQWGDEGKGKITDLLSRSADVVVRYQGGVNAGHTIVVDEKVL
KLHLIPSGILYPETICLIGSGTVVDPKVMLKEIKMLKDNDIDISGLQLAS
TAHVTMPYHCVIDAAMEERRGLKKIGTTGRGIGPTYADKSQRNGIRVIDL
LDERKLREALEIPLAEKNELLEKIYGKEAIDKEKIIEEYLEFGRLIKPHV
VDCTRIIHKASRNKKNILFEGAQGTLLDLDHGTYPFVTSSNPVSGGACIG
AGVGPTLIDRVIGVAKAYTTRVGEGPFPTELKGKINDQLCDRGGEYGTTT
GRRRRCGWFDGVIGKYAVEVNGLDCLAITKLDVLDELEEIKVCTSYELNG
EKIDYFPSSAEDFGKCTPIFKTLPGWKSSTANCRHLEDLPPPAMAYLRFL
AELMEVPIAIVSLGASRDQTIVVEDPIHGPKRALLSS
>Pro1619 purB, Adenylosuccinate lyase
MIERYTLPEMGAIWTEHAKFQSWLEVEIAACQANLELGKIPESAMKEIRD
KAQFSPERILEIESEVRHDVIAFLTNLNENIGDAGRFIHIGMTSSDVLDT
GLALQLKSSVKLLKKELKILKDVIRSKAKEHKNTIMIGRSHAIHGEPITF
GFKLAGWLAETIRNEERLEQLEKDISVGQISGAMGTYANTDPEIERIACA
HLGLTPDTASTQVISRDRHANYVQTLALIGSSLDRFATEIRNLQRTDVLE
VEEGFFKGQKGSSAMPHKRNPIRSERISGLARVLRSYVIAALENVALWHE
RDISHSSTERMMLPDTSITLHFMLREMSEVINELGIYTKNMVKNMNIYGG
VVFSQRVLLALVQSGMQRETAYRLVQKHAHAAWNTESGDFRTNLSLDKSI
TDVISAEQLNDCFSTELHQLNLDVIWERLEI
>Pro1420 purC, Phosphoribosylaminoimidazolesuccinocarboxamidesynthase
MAPNHGALLYEGKAKRVYYTDNSDEFLVHFKNDATAFNAKKHAQLEGKGS
LNCEISTEIFKLLERNGIATHFLNLEDDCWMLVQRVDVIPIEIVIRNIAS
GSLCKQTPIAPGTELSRPLMDLYLKDDVLEDPLLTEERIDLLNLLSSSQR
KEIQRLSLRVNDCLKEFMKGLDLLLVDFKLEMGFNGSGQLLIADEISPDS
CRIWDLKTNDQDDRILDKDRFRKDLGGVLEGYSEILRRIKAFNS
>Pro1421 purD, Phosphoribosylamine-glycine ligase
MNNEASHPSNSLPSLQKVLIVGGGGRENALAWAIAKHKKVEAVYVAPGNG
GTKKQSSCHQLAIEESNDEELLKTCISLKIDLVVIGGEKPLASGLADKFR
DAGLVVFGPGKNGAQLEASKKWAKDLMAEAGIPTARYWAANNKPEALDVL
AKINQPLVVKADGLASGKGVRVCQSIQETREAIEEAFAGKFGEAGTTLVL
EECLEGPEVSVFAISDGENLTILPTAQDHKRLLEGDKGPNTGGMGAYAPA
KVLNSEGMDHIKETILKPTLEALNKRNINYRGVIYAGLMLTNDGPKVIEY
NCRFGDPECQALMPLLGPELAQLLQAAALGSLKKAPFLKISPLMSACVVA
TTSGYPHNPKKGDLVSIQLDEKKDFPIQLFHSGTKLSKEGNLITSGGRVL
SIVAQGANYNDAFNLVYEAIKEVNFDGINYRKDIGHQIRNIDSIY
>Pro0191 purE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase
MGSDSDLPFLEPAIKVLEGFNLQVETRVLSAHRTPLKMVSFAREAEGKGL
KVIIAGAGGSAHLPGMVASLTSLPVIGVPIQSKCLKGIDSLYSIVQMPAG
IPVATVAINGGLNAGLLAAQILSTIQPELKIKISQYRKELHNQVIHKDKK
LIELGASKYLEEM
>Pro0004 purF, Glutamine phosphoribosylpyrophosphate amidotransferase
MCGIVGIVSNNQINQKIYDSLLLLQHRGQDSTGIATMEGSVFHLHKSKGQ
VKEAYRTRDMRILTGNIGIGHVRYATSGEAHREDEAQPFYVNAPYGIILV
HNGNLTNTRELEKELFSIDRRHTNSSSDTEMLLNVLATEIQSENYGSSLS
PEHIFSAISSLHKRVEGTYSAIAMIAGYGLLAFRDPYGIRPLVLGKRVLD
NGKTEWIVASESLVLENNDFDVVRDVVPGEAIFISNEGEFYSKQCADNPQ
LFPCSFEYVYLARPDSVMNGISVYEARLRMGDYLAKTIQEQITSGEIDVV
MPIPDSSRPSAMQVARQLGLEYREGFFKNRYVGRTFIMPGQAQRKKSVRQ
KLNAMSSEFKGKNVLLVDDSIVRGTTSREIVQMAKLAGANKVTFTSAAPP
IRFPHVYGINMPSKMELIAHDKSIDQIQETLLADGLVYQKISDLEQSILK
GSQVKNLDLSCFNGEYVTGKVTEEYLAWVGSKYSS
>Pro0298 purH, AICAR transformylase/IMP cyclohydrolase PurH
MPPIALLSVSNKEGLIPLAKELSIEYGFEIISSGGTAKTLQQAGILVTPV
AEYTGAPEILGGRVKTLHPKVHGGILAKKGDLFHQKDLKDQKIKAIDLVV
VNLYPFQETIKKPNISWEEAIENIDIGGPAMVRAAAKNHESVSVLTRPEQ
YQPFLQALKKGTLSNEMRRELAKEAFEHTANYDNAISRWMKLNAEKKSSQ
WIESIPLKQTLRYGENPHQSASWYSHQDQGWGGAKQIQGKELSMNNLLDL
EAALSTIREFGYDENLLATTSQKAAVVIKHTNPCGVATANSVSLALKKAL
DADRTSAFGGIVAVNSSIDLATASELKNLFLECVIAPNFENDAKLLLSEK
KNLRLLEMNKYYIDQSERNNIRSILGGLLIQESDDELIDEKSWEVVTKKQ
PSSIEKKDLTFAWKVVKHIRSNAIAIASSGQTIGIGAGQMNRIGAAKIAL
ETAGDKAKKAVLASDGFFPFDDTVRMAASHGITAIIQPGGSIKDNLSIEA
CNELNISMIFTGRRHFLH
>Pro1008 purK, Phosphoribosylaminoimidazole carboxylase
MENNDHQNFCIGVVGGGQLAQMLAKAGKKLGVDLIVQTRSENDPAVQNAN
GLVLSDTNDINGTRQLAQKTSCITFENEWVDIEGLSLLEDSGVTFIPKLS
AMSPLINKLSQRKLLKKLNIPGPEWLSLSSFKISDLKLEANWKFPLMAKS
SFGGYDGKGTMVINDFSDLKTLLQQVNPKQWFLEKWINYDKELSLVVSRD
LFGEVRTFPLVETFQTNQICNWVLAPADVIHPVIAMANNIAISLVRELNY
TGVLAIEFFYGNDGLLVNEIAPRTHNSAHLSIEACASSQFEHQIAIAARK
PVKSTELIAPGAIMVNLLGFKDSENIVERRLQLLKKINGVNLHWYNKENN
IPGRKLGHVTKLLSSIDIKQRRNEALQVLNQIRSIWPMT
>Pro0003 purL, Phosphoribosylformylglycinamidine (FGAM) synthase
MIDISFNRLIKSKDYLVDYNVELALKKEGLTKADYIEICNRLKRSPNRTE
LGMFGVMWSEHCCYRNSRSLLSNFPTTGKNILVGPGENAGVVDLGEGQRL
AFKIESHNHPSAIEPFQGAATGVGGILRDIFTMGARPIALLNSLRFGPLD
TPINVGLLEGVVSGIAHYGNCVGVPTVGGEVAFDKSYSGNPLVNAMALGI
METKEIVCSGAKGIDFPVIYVGSTTGRDGMGGASFASSELTQASIDDRPA
VQVGDPFLEKGLIEGCLEAFKTGYVVAAQDMGAAGLTCSCSEMAAKGGVG
IELDLDLVPAREKNMTAYEFLLSESQERMLFVVEPGKEELIMNKFRKWGL
QAKVVGKVLEENIVRVIHEKQIVVNLPADSLAEDTPVNKHELLEEPPGFI
KDHWKWDETSLPKVSIKGVHFKENNTILDWNQIILRLLDDPTIASKRWIY
NQYDYQVQNNTIIAPGIGDAALIRLREIENQNQNSNRGIAAVVDCPNRWV
ALDPERGAIAAVAEASRNISCVGAKPLAVTDNLNFSSPEDPIGYWQLAKA
CKGLSKACVVLETPVTGGNVSLYNETALPNGLKQPIQPTPVVGMIGLIQD
INSATRQGWKDQGDQIYLLGTSIDPSILNNQNISLAATSYLENIYGLKTG
RPPLIDLEFEKLVQLFLRESIANNLIKSAHDISDGGLVIGLAESCISSGL
GIECNLPEIDNRLDKLLFAEGGSRVLVSVSPNNIHNIKNSLNNFNIANSE
QISFNYLGTVTDNKYFQININQTKIIDLSVNEITNKFERSIPRRINSTIV
S
>Pro0854 purL, Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain
MTIGIVVFPGSNCDRDVHWATQGCLGMSTRFLWHESTDLNGLEAVVLPGG
FSYGDYLRCGAIARFAPVLSSLLEFVNKGGKVLGICNGFQILTELGLLPG
ALTRNQELHFICDTVPLLISSQRTQWFKNYNQSKNIFLPIAHGEGRYQCS
ESILKKLQDEDSIALKYKNNPNGSINDIAAITNKSGNVLGMMPHPERAAD
KDIGGIDGIKILQALLSN
>Pro1745 purM, Phosphoribosylaminoimidazole (AIR) synthetase
MDYKSAGVNVEAGRAFVNRIKASVESTSRPEVIGGIGGFGGFMRLPRGLE
KPVLVSGTDGVGTKLELAQDYGSHYGVGIDLVAMCVNDVITSGAEPLFFL
DYIATGKLTPEALTEVIEGIAEGCNQSKCSLLGGETAEMPGFYSDGRYDL
AGFCVAVVEENKIINGSKIKVGDQIIGIKSNGFHSNGFSLIRKVVKLAGV
NEKSCFGSRKVPLIDYLLKPTQLYVHLVQALLQANLPVKGMAHITGGGLP
ENLPRCLPDGLAASIDRNNWEEPSIYKWLRNEGDIPESDLWNTFNFGIGF
CLVVSPDQSKDLIDMCSANGFVAWNIGQVEEQPKQMQSRIVGLPT
>Pro0945 purN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN
MNSINIKSITSPNIISLPRFTPKLKLAVLASGKGSNLKAIIEDILSKRLD
AEIKCLIVSNPNCGAIEIANKHLIPVKVVTSNDFINRESLDQHLVNLLHA
YNVELVIMAGWMRIVTHILIDSFKNKIINIHPSLLPSFKGKEAVKNALNN
KVKITGCTVHIVEEEVDSGEILIQSAVQVNTGDTEELLLKRIQSQEHKII
SLGIAIAGQRLR
>Pro0853 purS, Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component
MPNFKAKVQVSLRPSVLDPAGEAAKSAAIKLGVKGISKVRIGKAIDIEIE
APNKQDAIEQVEILSDRLLSNPVIENWSLQLDSAYSSNHD
>Pro1184 purT, Formate-dependent phosphoribosylglycinamide formyltransferase
MTIFPKTLMLLGSGELGKEVAIAGKRLGCKVIACDRYEEAPAMQVADLAI
VLDMNNHNSLQKTIRDYKPDVVIPEIEALAVEALKDIEKEGINVIPNARA
TAITMNRDQIRNLAAEKLAIKTANYGYASNIEELKEVSKKVGFPLLVKPV
MSSSGKGQSLIKDKNDLEKAWDLAIKEARGDSKQVIIEEYINFDLEITLL
TIKQSNHQTIFCPPIGHEQKGGDYQCSWQPQKLSFDQLKEAKSIAKKVTN
ELGGIGLFGVEFFIRGEEVIFSELSPRPHDTGLVTLISQNLNEFELHLRA
ILGLPIPSIECVSPSASRVILSQESFAKVAYKGIEKALEIQNSKIMIFGK
PNTKKGRRMGVSLAQGKTLEEARFKADKSAKCIQIFEAKEAQS
>Pro0262 pyrB, Aspartate carbamoyltransferase
MSNWSHKHILDLSSFSIEDYQTVVELANRFKTIPRSGSRKLPALQGRLIA
TLFFEPSTRTRSSFELAAKRLSADVQSFAPSNSSLIKGETPLDTVMTYVA
MGAHVLVVRHGGTGVPEQLAKSLDQKKKNVSILNGGDGLHSHPSQGLLDL
FTLTQFFNKESPSPRNIAGKRIAIVGDILHSRVARSNLWSLTACGANVVL
CGPPSLLPDDFAKFVEAPPSGQKKDPIKNRGKVTISRCLKEALTDTDAVI
TLRLQKERMSENLLSNLDKYHNEYGITHESLKWCGKHVPVLHPGPVNRGI
EMSSELLEDNSISLIENQVSNGIPIRMALLYLLSADKN
>Pro0514 pyrC, Dihydroorotase
MNKSYLLDPIQILRGPNQTVTSDAVLIVNRHIKAFGQRARDLAYELKIDK
TSAEKLFFAPCLVDPHSVLEDYLNGKAETLWTLMKKAANAGYGQIALLPK
ASPWRDKPEYLYSIKNLGQDVLIHLWGGFSQKGAGEKLTSHKDLIDHGAV
GLADDDWMIPIELLKKGLILNETKEKPILLAPRDLAIQGHGLVRESVEAL
RAGWHQDPVASETIPLGTLLELQKQHPSSKIRLMNLSTAEGVNMLKKSSP
KPMASVFWWHLVADQSTVTSTDIGIRVSPSLGSSNDRESLKKALQERILT
GVAVHNISLDDAETKKPFSEIIPGISGYHLVLPSLWQELIKKSKWSVEQL
WEAISFGPSKILSLPPEELKVGSNRWLLFDPDQKWIQTRKYQEKGWETNS
NQPWEGIEMIGKIIDCGLS
>Pro0571 pyrC, Dihydroorotase
MSKERITLRQPDDWHLHLRDGDILNAVVPPTAKVFRRAVVMPNLQPPITS
LQAAIDYKQRIMNAIPTEVAFTPLMTVYLTDDISSEVLREGHKEGVLMAA
KLYPANSTTNSSGGVTDIKNIYSIFETMEEIGLPLLIHGEVTDQDVDIFD
RESVFIERYLDPLLTKFPDIRTVLEHITTDDAVQYVQASNAKLAATITPH
HLHINRNAIFQDGLRSDFFCLPVAKRERHRIALRRAAISGEPCFFLGTDS
APHLRESKESACGCAGIFNAINAIESYAQVFDEEGAIERLEAFASEFGPA
FYKLPLNENSITLVKKAIKIPSRFELNNADDLSNYIVPFHAGETLNWSFE
SIQPFSQKV
>Pro0225 pyrD, Dihydroorotate dehydrogenase
MKNRSWPNIFSSESLYKKFFKPILAKDEGVDAEQLTQLALNSLRQASLYR
NWPGISQALTQLEIELNRKDPRLEQKIFGCHFKNPLGLAAGFDKNGIAAG
IWNNFGFGFAELGTVTWHAQEGNPKPRLFRLSKEKAALNRMGFNNNGAVT
MRDILERQKLKSPGNRSSLIGLNLGKSKVTPLEQAHEDYASSLEILSSFA
DYAVINVSSPNTPNLRKLQDAKALRRLIKRLRRLPSCPPLLVKIAPDLDN
IAIDSLTTVAFEEGLAGIIAVNTSIDRLGLENRIIAQTKNPLSQENGGLS
GRPLRGRAIEIIQRLRKNAGADLTLIGVGGIDTPESAWERITAGASLIQI
YTGWIFEGPALVPKILEGLVLQLDRHGFKNISEAVGSNVPWI
>Pro0307 pyrE, Orotate phosphoribosyltransferase
MNLPIKSNAASKEKLLTLLALKAYKNGNFTLSSGNKSNHYVNCKPVSLSG
NGLLLLSNMMLENVEPDSLAVAGLTLGADPLVCGVALAATYAGRKLDALI
VRKEPKGYGTASWLEGPLPPAGSVITVLEDVVTTGRSSLKAVNQLQNAGY
RVNRIISIVDRQEGGAFEIKKAGLDLVSLFVLDEVYEKFKNT
>Pro1409 pyrF, Orotidine-5'-phosphate decarboxylase
MTLSFKPEDKLILALDGMSGAEVFMLIEKLPNLIWVKVGLELFTLLGPQI
INQLRDRGKKVFLDLKFHDIPTTMGRACYQAAKTGAELITVHACAGKKGI
EEANKSAVKGAKEVGLPPPSLLAVTVLTSWGSKDFVQELGIQQSLDQRVS
LLANLASSAGIQGCICSPLEVMKLRKDFPEPFQLITPGIRSCGENINDQN
RIMTPLEAIDAGSSKLVIGREVTSSENPSDAFNRICSQLI
>Pro1853 pyrG, CTP synthase
MAKFVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYLNVDPGT
MSPFQHGEVFVTEDGAETDLDLGHYERFTDTAMSRLNSVTTGSIYQSVIN
KERRGDYNGGTVQVIPHITKEIRERIHRVSANSNADIIITEIGGTVGDIE
SLPFLEAIREFKGDVGRNDIAYIHVTLLPFINTSGEIKTKPTQHSVKELR
SIGIQPDVLVCRSDRNINKELKTKISGFCGVHAEAVIPALDADSIYSVPL
SLKKEGLCREILKILELEDHQCDLEEWEALIHQLRNPGPSVTVAVVGKYV
RLNDAYLSVVEALRHACIAQNASLNITWVSAEKIETEGPENLLEGIDAIV
VPGGFGNRGVNGKITAIQWAREKRIPFLGLCLGMQCAVIEWARNIAGLKE
ATSSELDPNASHPVIHLLPEQQDVIDLGGTMRLGVYPCRLTPETMGHKLY
GEEVVYERHRHRYEFNNSYRNLFVESGYSISGTSPDGRLVELIELKSHPF
FTACQYHPEFLSRPGKPHPLFQGLIEAAQLRLPATPQEVFKNTLPNFQKN
K
>Pro0522 pyrH, Uridylate kinase
MSYSRVLLKLSGEALMGSKPYGIDPEIVQSIAQDVSKVVQEGTQLAIVVG
GGNIFRGLKGSSAGMDRATADYVGMLATVMNAITLQDGLERAGVETRVQT
AIEMQQIAEPYIRRRAIRHLEKGRVVVFGGGCGNPFFTTDTTSALRAAEI
NADVIFKATKVDGVYNQDPKEYPEAIKYESLTFQEVLSKEIAVMDSTAIA
LCKDNKIPIVVFNIFQPGNINKAVAGEKIGSRISNSG
>Pro1586 pyrR, Uracil phosphoribosyltransferase
MTDQNTPERVEILSKEELDRTLTRLASQILENISDSNKLLLLGIPTRGIQ
LAEVLASELQSKTGHKIEQGTIDPTFYRDDLARVGTRMSPATEISSSLEG
RQVVLVDDVIFTGRTVRAALESLQAWGRPQRVMLLVMVDRSGHRELPIQP
DFCGRQVPTRRTESIELRLKEIDGEEGVFLE
>Pro1378 ssnA, Cytosine deaminase
MFAQKKTSPNIQCIDALVPRSLIACGKGLLQAQITEEGLCPLRMHIKDGC
LNEIEVIQHSKESSLSLLLPRLIEPHAHIDKAFTWKSFPNFSGTYQNALQ
ANLEEQKGRTMQKVRDRAERSMKLSLKNGIRAVRSHVDSFDSSGQQTWEV
LKNIKSEWEEFVELQLVALVPLEYWTTKRGKDLARQVSAEGGLLGGVIVP
PYHKANLRELLINFFCLANDMGCGIDIHVDETSLTPGGGIREIIYVLEQI
DLDIPITCSHLSSMGLLPSNPLKLLAERIASFNINVVALPFTNFWLLARS
DKTSPIRRPIAPIKQLQNAGVNVAIGGDNVQDPWYPGGNFDPLSLMAASM
AFAQIAPWNRLGLSTFTTGAARIMQLEWDGIIDIGCPADFVLLDADSWAG
AMSTPPIRKVMINGHWIETDDLSLKEGFLSHA
>Pro0152 tmk, Thymidylate kinase
MKGIFLVLEGIDGCGKSTQIEHLAQWLPLSGLMPSAAKLFITREPGGTRL
GKSLRQLLLGTSPTDESPKPLTELLLYAADRAQHVSQVIQPKINNGDWVI
SDRFSSSTLAYQGFGRRLDKSLIKELENIATQGITPDLTFLLEIPVSESI
KRRENTRKDRIESEGEIFLKRVSDGFSYIAKNDNWLVIPANQKKDIVSKQ
IENKLINYFQNISSLKNERS
>Pro0849 upp, Uracil phosphoribosyltransferase
MAMTLRVVIPPHPLIGHWLSILRIESTPSPIYSTALEQLGKWLTYEALRD
WLPNSKREINTKQGKTEGILIETQIPLIIIPNLPGGLQMWQGAREILPNA
SLCLGCIPQTIERNAGIIVYCDQIDSGKNLLQNLERLKTLGVESPRIRII
TALASTYGLKEIGENFPDLKIYAASVDPTLSENGEIIPGIGNPSLRLNTI
ITPSH