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# Tropheryma whipplei str. Twist, twist

>TWT282 HIT-like protein
MTSIFTRIINREVPAEILFEDDEFICIEDIAPKAKIHYLVIAKHPWKDVT
EAVRDDPLFVNKILAIAVRLTKDFGSQFRLIFNTGALVGQTVFHVHAHIL
SGEALGE
>TWT751 unknown
MEHTVKITGEHKDLYRGSFRDTPDEKIMRKALCLAHAAGEKGEIPVGAVI
ADVNGKTIAEGFNKREESKDPTDHAEIIAIRKASQMLKDWRLSGLTLFVT
MEPCTMCAGAIVTSRISRVVFGAFNNKTGSVGSRIDILRDEILNTNIEVV
SGVLISECEGVLAKFFADLR
>TWT621 unknown
MEIVFVSENENKIAEAREILLPLGFQSIFCGVTCRETGLTFTENAVLKAQ
AAVGSVKDVPIMADDSGICVDALNGMPGVLSSRWSQDGRNIDLLLWQMRD
VPDVHRTAHFVCSIACVMPNTEVRTVSSVWHGRILHAPDGTGGFGYDPVF
LPDGYSVSAAGLGSDLKNRISHRYKALRLMSSLLKRTYFSCHA
>TWT051 cytidylate kinase/GTP-binding protein fusion
MDFTSIVAIDGPAGSGKSSVGRAVAQYLGYGFLPTGSYYRAFAFLLDQTK
DLDSQLDSFISSVRNDLDPYNSGFNVHIDDSPFFGSSGISASSRNIASEL
NNPEITSKTAAVARNKSVRVRLNEYFRKLCSESIYPAIVLEGRDATTVIA
PNARVKIFLTASLVKRAARRSEQLSSEPPNSVLEALRQRDEADNAVTDFL
SDDSSRITLDTSDLTFSESVARVLEVIEQAGMPFVSDKWVGENADVLAAS
GELGATVVIVGRPNVGKSALVNCILGRREAVVENRPGVTRDRVVYPAFWA
GRPFTLVDTGGWECDAEGLDAEVVAQAEIGMSIADIIIFVVDVQHGPVST
DAVIARNLQRQNKPIFLVANKADNASSDSDVAQFWSLGLGQPYACSATHG
RGVADLMDIVMQSAQVHTPSFCSGAPRVALIGRPNVGKSSLINQLTNSRR
AIVDDLAGTTRDPLDALAVIGDKSWLFVDTAGLRRKFKSQKGADFYAYLR
ATTVLRRTEIALLLLDASHAITEQDVRIAEMVVESGRALVIAINKWDLLD
EERRYWLEREIDNTFFRFAWAPRVNISARTGRGVKQLATALQTALTNWNT
RLNTARVNHFLQRITREQPHPTRGGRRPRILFASQTGVAPPTFTLFTTGF
LEPTYRRFLQKSIRSQHSFTGSPIILSVKIRASRNR
>TWT322 unknown
MIDVLDHFATTVIDSARSYGPCHDAIEDMVGQDDGDGLAHYARKGEITRS
YVMGIPVIALCGKRWLPSRLPDKLPICQTCSDIYNSLSD
>TWT263 unknown
MQEGSSDFAGIPDGYKRLWTPHRVVYLEGARHDGNPETCPFCSAYRKTDE
EGLIVYRGDLSYVVMNLYPYNSGHTLVCPYRHIATYDLASSDEILEMGLL
LQKAILVSKRVLGCEGFNIGINQGRVAGAGIAGHLHQHIVPRWAFDSNFF
PIIARTKALPKLIEQVRCDLQRGWDDLV
>TWT796 unknown
MCFSLHFFSACCLYISIRCTAYGLALHSADISANTDINLHCALSRSLGGW
GIVKIIIDVMPKPGLLDPQGRAIASVLTERGWDNSTRIRVGKRFELCVDP
VSETCELDFIRDLANDLLINPVIEDVVDIRIEDD
>TWT085 unknown
MKSMNKKLAVFLLARDLSFVLSATILEVWCLSSVTWPVNAIFGVVLPIVL
GLGWACILSTSPAISASIYLRSIMYLVVSLLAALSLIDFRSIGLAVAHLV
LASLIGFVLVLLD
>TWT534 adk, adenylate kinase
MRAIMVGPPGSGKGTQCGLIQSRLGISVIATGDVFRERMKTDMALRDIVS
SGGYVSDSTTNRIVEDCLDKEDVSSGFVLDGYPRTLQQLDFLEGFLKRRA
LTLDAVFSLEVATDLLIERLRARSKESGRTDDRDSVIARRLEIYTEMTLP
IIDACEEKGLLHRIDASKGIEEVFQSIKDVFDRVTI
>TWT366 carA, carbamoyl-phosphate synthase small chain
MLSFRSAVFVMEDGSCFEGVPFGAVGTAFGEAVFSTCMTGYQEVFTDPSY
TAQILVMTAVHVGNTGINDFDNESDRMWPSGVVIRDPSPIASSFLAKMDL
AKALASEGVIGISEVDTRAIVRKLRTSGAMRAGIFSQPDRPLPDLVDQIR
GTQSMHMRSLTSEVSTTSRRFISSESHFATLLVLDLGVKKSTINLLLEQG
FDIWLMPHNISFDEAMQIKPDAIFYSNGPGDPAASGTQVDLLRSLLRAGL
PYFGICFGNQLLARALGFETKKLLFGHRGINQPVFNRATKQVEITSQNHG
FSVDMPIDRISVSPLNFGRVEVSHYCLNDYEVEGIRCLDIPAMSVQYHPE
SCAGPHDSRYLFREFRRMVEGHLERRYNAEP
>TWT365 carB, carbamoyl-phosphate synthase large chain
MPNPRDIGSVLVIGSGPITIGQACEFDYSGTQACRVLKEEGIRVILLNSN
PATIMTDPEFSDATYIEPMTIEVLEAILDKERPDAVLPTLGGQTALNLAM
QLHNKGLLEKYGTQLIGATPEVIARGENREMFRHIVLSSGAEVATSEVIT
SVEGAVLFAQKNGYPLVIRPSYTMGGLGSSLVHTESELVDSVKQGIEASP
NGQVLLEESIVGWKEYELELMRDVAGNTVIVCSIENIDPVGVHTGDSVTV
APAMTLTDREYQNLRNIAIAIIRMIGINTGGCNIQFAVNPTDGRVVVIEV
NPRVSRSSALASKATGFPIAKLAAKLALGYRLHEIKNDITKKTFASFEPS
LDYVAVKIPLFAFEKFPKANPELTTSMKSVGEVMAIGRNFTTALQKAMRS
LDQPHMCFHWQPFESPGHSIASDVPDPREYYLDFIRTPLPSRLVAIQQAL
RFGASIDEVHEASRIDKWFVSQIDLINKTADSLKDLSMDCLSRAKMHGFS
DRQIADLLRIDEEDVRKRRSALGIVPVYKTVDTCAGEFPAVTPYYYSSYD
SENEAIPSPSRKVIIIGSGPNRIGQGIEFDYSCVHAAMALSGMGIETVMI
NCNPETVSTDYDTSDRLYFEPLTLEDVLEVISVEQRNGDLLGVIAQLGGQ
IPLSLAKSIQHEGIPILGTSPESIDLAENRDLFSNLLRSLNLPTYEHRTV
SNKDEAIIAANKMGFPVLLRPSFVLGGRGMKVIHDSQALEDYFNTFHAVD
SEHPLLIDKFLSDAIEVDVDALYDKHELFIGGIMEHIEEAGIHSGDSSCT
IPPVTLGKNIVNQIVSTTHAIARTLSVLGPVNIQFAIASGILYVLEANPR
SSRTLPFVSKATGIPLAKAATRIMLGHTIEDLQREGLLPQRDMRFFNPTD
PIAVKEVILPFKRFRTKSGEFLDTLLGPEMQSTGEVMGIGPTFPIAFAKS
QQAAFSELPRTGAIFVSVADHDKRKVVLPAMRFYKLGFKIFATSGTADTL
RRFGIDVVTIQKFSEAKKTSSRSVVDLIREGRISLVINTPSGGVSIADGY
EIRVTALACEIPVFTTISEMNAAVISLESGSHEIASLQELYSSRARSAEN
LCG
>TWT787 dcd, dCTP deaminase
MLLSDVDIQAALEDKLIQIDPFDPQMLQPASLDIRLSRYFRLFNNHTYAY
IDPAEPQEALTRLVEVAENQAFVLHPGEFILGSTCETVSLSNDLAARLEG
KSSLGRLGLLTHSTAGFIDPGFSGQITLELGNVATLPIKLWPGMKIGQLC
FFQLSSPAKNAYGSPVCASRYQGQRGPTASLSHQHFYRARFTEIGL
>TWT018 deoD, purine nucleoside phosphorylase
MLLDGGVLVGLSWKSAAMEDICNTELTAATLAAKQIADITGIARHDIAVT
LGSGWVDAVSNLGELITTIPAQDIHGFFPPVLAGHSGVLTSIRLTCGVYV
LVIGARTHLYQGHGPEAVVHGIKTAHAAGARVAILTNGAGSTVPDWGPGE
VVVIKDHINLTGKSPLSGANFCDMSDIYTAALRQKILQMAPNIPQGVYAQ
MPGPQYETPAEVKMLRTIGADLVGMSTALEAIMAKSLKMNVVGLSLVTNL
AAGIGTGQLSHDEVLTVSEQARQKTSAFLVELIRDIGQDLSGRK
>TWT287 dgt, dGTP triphosphohydrolase
MTLLTCKTFRARCSYTSHMKQFTYNDFDRERLYPEKTENIRDSFTRDRAR
VVHAAYMRRLADKTQVYSPLLHLTTVRNRLTHSVEVAQIGMDIAHLIGVN
QNIVDTACLAHDIGHPPFGHNGERVLNKWACEIGGFEGNAQTFRVITRLE
PKVYAPDTRRSFGLNLTRASLNAVCKYPWSLKDARRFCIATKETTGLQNL
LCDCDAVHKFGFYEEDRETFSWVRKLSRAHILSIEAQIMDFADDVAYSVH
DFEDSLLLERNLHSVLRSQNLPHQIQRFMTETFSCEIADKADEAFSNLSE
MWRDLSRNIAFGSLHNKYLTGISMRGFLARLKNLTSNLIGRFAYAAIERT
RESLVERDRSDAQLVVPNTTLAEIALLKSMVFVCVMQKRKQFYVLQAKAL
LRLVEKIWELACKDAYALDDLFREDWELAKCEAEKRRVVLDQIASLTDLD
ALLLMQRYCSESDAVREFLMKSESARSQL
>TWT487 dut, deoxyuridine 5'-triphosphate nucleotidohydrolase
MTVEVLFKGGYTPQRAFDGDAGFDLQSSHTAVIQPRCRQVVKTGIAIALP
DGYAGFIMPRSGLASENGITLVNSPGVIDAGYRGEISVVLINTDLHQAFH
ISQGDRIAQLVIMPVCHASFIEVDTLPGSARGISAFGSSGRHDTRG
>TWT363 gmk, guanylate kinase
MRRPPPKPDWQSASKKGVEVRKIRAEVKKKIAFLPHCSLYFLRYGRNRKG
SVISNMRVADLLSPLPGIGRVKLARVMLELGIASRKRIAGLGSLQYVRLE
AFLKTHLGIQRMQLFDLWTDLLDLLTIVAGPTAVGKGTVISHLRKCHPQV
KVSISATTREPRDSERDGIDYYFVTDEVFDCMVRSGQMLEWATVHGLHKY
GTPKEEVERLLHTGQPVILEIDLQGMRKVRKILPAVRTVILLPPAWDDLI
CRIKRRGSESQDEIDARLATAKKELEAIGEFDYKIVNADVEIAANELWLA
MNRV
>TWT079 guaA, GMP synthase
MRPVLVVDFGSQYSQLVVRAIRECGYYAEFASPSISAAECLALSPIAIFL
SGGPASAYKDNAPKLDEEILNCGIPVFGICYGFQLLAQAFGGSVKKANAP
EYGPADITIVNKAFFSGQPDRQTVWMSHGDSVIRAPKNFCILSTSQDAVL
SFCNRDRTIAGVQWHPEVKHSRFGKHTIKAFLSSFAAPNWDPEQTICGTV
DSIRKTVGCKRVLCALSGGVDSVVAATLTHRAIGDRLRCVFVDHGLLRLN
EREQVEEYCSSLGLNVSTYDASDCFLSALSGIRDSEQKRKVIGREFIACF
SKLQERFDIKPHFLLQGTLYPDLVESGATPGGATIKSHHNVGGLSDNLGF
ELLEPLKYLFKDEVRKIGLQLGIPKHIVHRQPFPGPGLAIRIIGEVTNKK
LSILRAADAIVRHELRDWTDIWQCPVILLSDVQSVGVRGDSRSCGFPIVI
RPVSSDDAMTADWYRLPYDVLARISGRITNEIPEIVRVVLDITPKPPATI
EWE
>TWT076 guaB2, inosine-5'-monophosphate dehydrogenase-like protein
MSKPQTTERRLMEVGFSRNARRAFSLDEVAVVPSRRTRHSSEVSIEWKMD
AFSFDTPIISSPADSVVSPSTIVELSEFGCLGILDLEGVWTRYENPEPVL
REISALPEEKACLGLQKIYSEPIKRHLLERRLQELRDAGVIVAGCLSPQT
TNALYKSVISAGVDIFVIRGGTVSAEHVSKSDNVLNLKRFIYELDVPVMV
GGVATYTAALHMMRTGAAGVLVGFGGCAGSTNHASLGIKVPMATAIADVA
AARKDYLDESGGRYVQVIADGSMNTSGMAVNALALGADAVMMGTPLVRST
TSPGFGYHWGREAHHMTLPRGRRAYIGQTASLQEIIQGPGHSPDGTVNFA
GAIRRAVALAGFQDLKNFQRVEMVVIQDQRRCCA
>TWT589 hpt, hypoxanthine-guanine phosphoribosyltransferase
MVITFTCTPYAVNCKHMKPLLSEAVIHRRLAQLALQIDEDYRGTSIVLLG
VLKGSIMLMADLSRLLSSDLRIEWVTLSSYGNDTVSSGSIRIVHDLDADI
RDRHVLIIEDIVDSGLTLGWLLAKMRERRPASIEACVLLRKPHARGTDVR
YLGFDIPDEFVIGYGMDYAEKYRNLKSVYVLEQ
>TWT475 ndkA, nucleoside diphosphate kinase
MEQTLVIIKPDGIRRGLIGQVLSRIEAKGYQIVDIRMLVPDRQSVEEHYL
EHRDRHFYLPLVDFMTSGPIVLVRAEGHGVVDALRTLVGVSDPTLALPGT
IRGDFGRNWGLGVIQNIVHASDSVKSAKRELDIWFP
>TWT683 nrdA, ribonucleotide reductase alpha chain
MSLTVVKRDGRKQQYDSRKVCAAIEEALSGSSDAITEQLSSELELTLFDG
ITTSQLDESLIQVALQNVKDDPVYDRVATRLLLKSIYRSVLGEYKNCCQL
RDLHVKHFRGFIEKGVEEGILDRRLDGRFDYDRLSRALDPQRDTLFKYIG
LVTLNNRYGIRARSGKNLEVPQYLWMRISMGLSVLEKDPTGSALKFYEKM
SKLEYLAAGSTLVNAGTCTPQLSNCFVMEMQDDIEHIAKTTRDVMLLTKG
TGGIGLSVTKLRAQGSPIRSNNTRSTGPIPFMHTIDSVLRAVSRGGKKFG
ALCFYMENWHMDFPEFIDLRQNSGDPYRRTRTANTAVWISDEFMKRVIND
REWYLFDPLETPDLNELYGAEFSKRYEYYVNQAEAGRLSMFKKLGAREQF
RAILMSLQTTSHPWITFKDTINLRALNNNTGTIHLSNLCTEICLPQDREN
VSVCNLASINLSRHLIDGEIDWQLLEESTRLAVRQLDNLIDITCSSVKES
DNSNNLNRAIGLGIMGFTNLIERLGYSYESEQAFDLIDRLMEQISFVAID
ESCNLAEERGPYKNFHGSRWSKGMLPIDSIKIVSQNRGVPVSVNTSYRLD
WDSLRKRVRNGIRNATLLAIAPTASIGLVAGTTPGLDPQFSQIFSRSTSF
GKFLEVNENLVLDLKRRGLWERVREDILRSQGNIQQIDAIPGEIKANYKT
SFQLSPYAFVQVAARAQKWVDQAISRNMYLESRDISDMVSVYTTAWEMGL
KTTYYLHMKPRHQAEQSTVKVNKRTEGGNRRGFAGFSKNKDV
>TWT682 nrdB, ribonucleotide reductase beta chain
MGILGTGIQDGLLLKPVRYQWAMDLYEQAVANTWFPNEIQLGEDIADFKK
MTHEEKHAVTFLMSYFNPNELLVNKALAFGVYPYINAPECHLYLAKQMWE
EANHCMSFEYVLETFPIDREEAYSSHIEVPSMARKEEFEVEYIRRMTEET
LDITTTEGKRDFIRNLVAYNVVLEGIWFYSGFMAALYFRQRNLLRNFGSL
IDWIVRDESLHLKFGINLILTVLEENPDLQTSDFADEIRGMIIAGVEMEE
EYNHDLLPNGILGLNSGYINQYVKYLADRRLEELGFDPEYNVTNPAKWMA
TANDTFELVNFFEAINTSYESNARSLS
>TWT187 prsA, ribose-phosphate pyrophosphokinase
MTDLLSCAPHARGANNRPGFSDRDVQNDGPMRNLVLIAGRSHPDLARATA
ESLGVGLLQTDIRTFANGEIYTRFNSSVRGKDVFVLQTGCDPVNDGLVEL
LLLIDSCKRASAKHISAVTPCYPYSRQDRKGYGREPISARLVADLIACAG
ADRIITVDLHASQIQGFFNGPVDHLTGVPALIKHVKSLRIDNLTIVSPDI
GRVKVADVWSDKLNAPLAIIHKRRDPRVHNNVTMHEIVGDVRSRVCLVVD
DLIDTGDTLAKAAIALKKAGAVKVIAAATHGIFSTPERLVSCGEIDHVIV
TDSVPASKVFDRVKTVSIAPLLACAICEVVTEGSISEMLDCVSKRIDN
>TWT792 purA, adenylosuccinate synthetase
MPATILIGAQWGDEGKGKATDLLAKDIDYVVKFNGGNNAGHTVVIGGDKY
VLHLLPSGILNENVVPVIANGVVINPEVLFDEIATLNSRGVNTDKLVISA
NAHIIAPFHRTIDLVTERFLGKRQLGTTGRGIGPTYADKINRIGIRVQDL
FDKSVLRQKIEGSLSNKNHMLVKVFNRRSVSVTEMLDYLLSFAERMRPMI
ADTSLLLNNALDCGKHVLFEGGQATMLDVDHGSYPFVTSSNATVGGAITG
AGIGPTRVNKVIGVAKSYTTRVGAGPFPTELHDEYGEWLQKRGYEVGATT
GRKRRCGWFDGVVARYATRINGITDYVLTKLDVLTGLDRIPICVGYKVGD
SVFREMPVSQSDFHHAVPIYEDLPGWQCNISECESFDSLPPEARGYVLAL
EDLIKARISVIGTGPERENIIIRHPLGIF
>TWT791 purB, adenylosuccinate lyase
MSEDEYDSLSPLDGRYGPAVRALRGFLSESALIRERIRVEIGWVFFLWRK
AVFGLAEPTKEDERFLSSIVHDAHKNIPRVKKIEERIQHDVKAVEIFLRE
RFTQQGLGNIVELLHFACTSEDINNLAYALNMKAALSEVILPSIDELIGH
LEKMSQKYAGDAMLARTHGQPATPTTLGKELLVFVYRLKRQRKNLEDVQF
LGKFSGATGTFSAHCVAAPNYPWQEWAKEFVNSFGLIYNPITTQIEPHDW
QCELLERVGHICRILHNLATDMWSYISFGYFQQGFISESVGSSTMPHKVN
PIRFENAEANLEMACGIISCIVASLSTSRLQRDLSDSSVQRNIGVALGHS
LVAIDNLKRGLAGIRLNKNRLTEDLNNNWEVIAEAVQTTIRAEILACKSN
EANPYERLKDFTRNKKITKHTLDEFITNLDLSEHAKKRLLELTPSKYTGL
AERMVQAHSSGTGGTKNSIGTGGTKNSSGAG
>TWT109 purC, phosphoribosylaminoimidazole-succinocarboxamidesynthase
MTRKLEIPESRDLPDWSHIGGGKVRELYVHRQYKNILLMFASNRVSAFDF
VLEPEIPEKGRMLTQMSNWWFRKLPAENHLLENYDQELYRDLASHIPSHI
LERSTICRKMDIIPFEFVIRGYLTGSAWADYLENNTVYGIKLKGKFRQGD
RLPGPIFTPTTKSRTKDTPVRYEDLVNAIGLSHAQQLREMCTDYYTTAEQ
IARNKGLIIADAKFEFGIAEGKVYLADELLTADSARYWDINSWGQFDLPI
ERRLDSFDKQAVRDWVKCNSGKNITPQNITPLRLPQELIQTVYKKYKTLL
AKLTG
>TWT725 purD, phosphoribosylamine--glycine ligase
MKILVIGSGAREHAIAAAIDSEGSHEVCVSPGNAGIAQTINCVQTTSDAD
LISIAKNFDLVVIGPEGPLAGGLVDRLKSSGATVFGPSQAAARIETSKHF
AKEIMANANVRTAKSVLVNNVDDLSRALKASSRPYVVKADGIAAGKGAIV
TGDRDAAYRHGSYWIRKGPVLLEEYVKGREVSLFFLCDGRVLVPLSPAKD
YKRLGESDTGPNTGGMGSHSPVTDLPANFVEEVQEAIAYPVIKQMAACGI
VFRGLLYCGLALCDDGPKVIEFNARFGDPETQVILPRLTSSLSELLYATA
KGDLRNISKPSFNNKAAVCVVIASGGYPEIPAGDTPIIGLNGTGDVQVLF
AGARRNYPDEPDILHSHGGRIMNIVSLDKTFAKAREKAYRAVDQISITNK
QFRRDIALEEEFMETNPLG
>TWT027 purE, phosphoribosylaminoimidazole carboxylase catalytic subunit
MTGKNINDEGSKCPALVWLLMGSDSDWPVMSGAADILQQMNISFRVNVVS
AHRQPEKMISCAKRARDMGFKVLIAAAGGAAHLPGMLASVTTLPVIGVPV
GQKNLSGLDSLLSIVQMPSGVPVACVGIDSAKNAALLAARILGVQSADIE
ASRIADSLSAYQQSLFDQSNEKDRMINEPK
>TWT723 purF, amidophosphoribosyltransferase
MNLEHYSRDSVLRGDGAKMCGIVGLIGSEPANQAIYDSLLLLQHRGQDST
GIATDESGILHLRKARGYVREAFRTRHMRSLLGRVGLGHVRYATQGSVSS
EEEAQPFYVNAPYGIAMVHNGNLTNASKLSKELFHTDRRHLNTSSDTEVL
INVFANELQQSVSGFELSPDQIFSAVSRVHKRVEGSYAVVALIAGTGILA
FRDPFGIRPLVLGARESKFTSNTEWIIASESVVLEAQGYKLLRDFAPGEA
VFITQQGEIFMTQCAQNPQLNPCAFEYVYLARPDSVMNGVSVYEARLRLG
DTLSTTIKQQMPCGNIDVVMPIPDSSRPAALQVSRNLGIEYREGFLKNRY
VGRTFIMPGQLQRKKSVRQKLNAMGLEFRGKNVLIVDDSIVRGTTSKEII
HMARSAGANQVFFTSAAPPVRYQNVFGINMPTSSELVAHNRQLQEIRQYI
DADRLIYQSIEDMRRAIMHGGEFKRLEDSCFSGEYVTGRVTQEYLDWVEN
TQSS
>TWT084 purH, phosphoribosylaminoimidazolecarboxamideformyltransferase
MTTNIRIKRALISVSDKSGLADLAEALAAHSVKIVSTGSTAEFIRGVSIP
VRDVSEVTGVGELLDGRVKTLHPKIHAPILADTTSQMHRAQLQQLGVDAF
DLVVVNLYPFFEISKNSEAEFSDVIEQIDIGGSALIRAAAKNHTRVVVIV
DPSDYIHVINSLERGAPSRLRHQLAIKAYSHTSEYDLHISRWLSERFYKH
TLYSSSDSVGDVCDNNLDSNDHFVELRGKKLGDLRYGENSHQKASLYLSC
KESVPQLGLASAALLGGKQMSYNNYLDADVASRIVNSFDLPTVSFVKHGN
PCGIASNIEVAIACRNAHECDPTSAFGGVVAVNREVTLDVATHLLPIFIE
VVVAPGYDPQALQLLLKKKNLRVVELPECASYPQDQLRQISGGFLVQDAD
KFDHHDTFSSWTQVSGPRIFMDAGADNETLMDLEFAWKSCAFVKSNAILL
AKNMASVGIGMGQVNRLDACYLAVNRAGSRSLGAVAASDAFFPFSDGLDV
LINSGVKAIVQPGGSVRDNAVIAAAQQAGVTMFFTGKRHFAH
>TWT026 purK, phosphoribosylaminoimidazole carboxylase ATPase subunit
MPIQLKDIETITATDAASTEPYAIFLNPRSINRLKTNILTNIPAIPTMPK
VAICLYRALFTRQNALCMLSIARIASPAQYNLRLMFERLSCSVGVIGGGQ
LARMMIAPAQALGVDLKVFADTPDSSAALAATAFGSPENGAAVLEFAQTV
DIVTFEHELVPADVLQLLDERGIEMLPRPRALRYAQDKLALRRYLDEISV
NQPAWAEVRSEGDLERFISEHGGCAVVKTGGYDGRGVQVVTLSSEIDTCR
NGGFLAEERIDFVCEVSQLVARSSIGEICVWPLTQTIQENGICVQTITPA
LGLSGGNALNQLTTFHDGRTRTPHAPLHSELITKLQDSAKTIALDIARGL
NVVGVMAVEMFITQDGKLLVNELAMRPHNSGHWSMAASITDQFEQHLRAV
LGLPLGATDMSHNCAIMVNIFNSISPAQYREVMTHWPDAKLHIYKKQPRP
GRKIGHVVFAGEDLQQLAIAAEECRQLLRESHAV
>TWT794 purL, phosphoribosylformylglycinamidine synthase II
MLSFTPRIGSRDYSCEAGYSVNMSLPADRDTAKKPSAQKPSAHAQNATAA
VDVTALGLTESEYTQICSLLKRSPTKSELAIYSVLWSEHCSYKSSRRHLR
QLADLTEVTKKHLLVGIGQNAGVVDIGGGWAAAFKIESHNHPSFIEPFQG
AATGIGGIVRDIIAMGAKPVALMDSLRFGAASDPDTQRVADGVVSGISFY
GNCLGVPNIGGETAFDPVYQGNPLVNVLCVGVMRRENIRLANASGPGNLV
VLFGAPTGRDGIGGASVLASDSFTSDAKANRPAVQIGDPFVEKLLTECCL
ELYAADLVVAIQDLGAAGISCAASELAHNGRVGIRLDLSAVPLRDTTLAP
DEILVSESQERMMAIVHPDNLEAFFEITNRWGISGAVIGEVDNSQYLTVV
HEGKTLVRLNPKTLTGPSYNRPVKKPAYLIRRSAANRLPVTNDPHLLRED
ILQVISCPNLSDKSVITNQYDRYVQGNTALCHPDDAGVIRMYKNTGVALS
CDGNSRYSYLDPHAGAQLAVAEAYRNVSVVGATPLAVTNCLNFGNPENPE
VMWQFRETCRGLSDACKRLEIPITGGNVSFYNQTDGKDIFPTPVVGILGI
VDNLTQTLTSGWNAPDLFIYLLGVTRPEFGGSVWADTMYGHIGGVPPKLD
LARESRLSNLLVAGAKKRVFESAHDLSEGGLIQAIVESCLRHGFGADIAL
DTIRATSLTEALFSESASRVLVSCRSQEDLRDLCRRNSYEYTLIGTTRHT
GELTISEIGKFTLNELSDARQKVTRVLFRG
>TWT724 purM, phosphoribosylformylglycinamidine cyclo-ligase
MMDPYAAAGVDIVAGQLAVEAMRHAVEATHNSRVPEGLGGFAGLFDISFL
KRYRSPLLVTSTDGVGTKVVIAQELDKHDTIGQDLVAMVVGDIAVVGGKP
LFMTDYIACGELIPERIAQIVGGVARACQEIDCVLLGGETAEHPEVMARN
QYDLAGAATGVVEASDLLGKDKVKTGDVLIGVASSGLHANGFSLVRKICR
DVSFAEYCPDLQTTWGEALLEPTRMYVNLIRDLIKTGKLHAASHITGGGI
PGNLPRILPEGLGARLHPWPIPDLFKVLCEFGSLSLSEVKNAWNLGIGLI
IVASSTSILEDIDDSWQARLIGEVIDGEAIQWTGSLS
>TWT083 purN, phosphoribosylglycinamide formyltransferase
MSDMKTAMRLIVMVSGIGSGLLRLIRACEQKELKAEIVAVGSDRHAPALS
HASDYGIPFFVSPFKEYSNRDAWGANLLNTVLAYKPDLVVLSGFMRILPS
CVVDALSPNLINTHPSYLPEFPGMNAVEDALRAGVKTTGASVIRVDNGID
TGPVISQMRVKVYSSDTCQTLHSRIKKVEHLLLCRAIKNIYTEQFILKNL
LHNSVRRPSGKTGDR
>TWT795 purQ, phosphoribosylformylglycinamidine synthase I
MVRVGVVTFPGSLDDKQTLRALSFAGCAAVQLWHASDTLSSVDAVILPGG
FSYGDYLRPGALASRSRIMVRIIEAAHQGMPVLGICNGFQLLTESRLLPG
AFVANKASRFVCLEQSLIVENNSTPFTMNFSKNQNVIIPIKNSDGCYFAQ
TEDLDRIENEGRVVLRYAGSNPSGSSRNIAGICNEQGNIVGMMPHPEYAV
EPGFGPPGLHGAPVFSAISSWINNAR
>TWT196 pyrB, aspartate carbamoyltransferase
MTAHNTPKVHCVIRQALRGQRIGPRQLAEQIGVDIKQLWSWLEPTWSQTL
DIPQSILHDLEDAIDDTSAFYNTQHLLSIDQINRRSLERLFYVTDMFQPL
ARRQVRCNILNGAVLVCLFYEASTRTRFSFSTAFSRMGGAVVTEADMLQS
SSVAKGESTSDTSRVISGYADIVVVRHSELGFAERYASDSLVPVINAGDG
SGEHPTQAILDVYTIESEFLYREKTIDGSCIAIIGDLKHGRTVHSLIKLL
SLYEGLTFKIFSITDLELPNDFHDLLSGRGHTLEVCDSLRNAVNAADVIY
ATRVQTERIAQDLTAVTGCRLTREVLDDCKKDVIVLHPLPRDSRPDALDI
GTDLDSYSGFMPFGQANNGVPVRMAIFSEILGITDKIEFADSIPWARRIP
YPQALP
>TWT367 pyrC, dihydroorotase
MTRQSFFIKNVTLPGLGARTLFLSGGLIQEIICKDIEEHQFLSTKNTDKA
SCRVIDAEGFIALPGLVDLHTHLRNSRDGSIRDVTSAAIAGGYTTVSSMP
NMHPVQDSPEAVNILKAIAKEDAVCDIRPVGAVTKGLRGNEITDMHSLLD
AGVNIFSDDGNCVHDPGIMHQALSFAGRNNCVIAQHAQDPTLTKSAQGDT
QGPIVAPKSLWPSIAESTIVARDILLARAANARLHVCHVSSQESVYAIAW
GKSLGVQVTAEVTPHHLLFYDSLVMTGDTRFKVNPPLRSKESVECLRDAL
IRGVIDVVATDHAPHRNKSPFWHSAPNGMTGLEFSVSVIQKIFVNSGHLT
WPEVVRIMSNKPAEILGMTPNTVKEGSAANFFLYNPDVTRFVTFDDSLGP
SVNSPYAGMNLPGKVMYTFYEGRLVFEN
>TWT238 pyrD, dihydroorotate oxidase
MYSYFLNFLKCVDPELAHRIAAVALKSGLGMFVPQRFHIHLGTTSMGLYF
DTPLGIAAGFDKFADLVIPLYSLGFGHVEVGTVTLHPQPGNKKPRIHRVM
SQKALINSMGFNNPGAQKMRENILKVRKSGRRLPIIGVNIGKSKVCPLEE
SAKDYVKSFELLADVSDYLVINVSSPNTEGLRTLQSVGNLNKILRSVKPI
ADRFKRPVLIKISPDLSNSDVTNIALLVKEFGLAGVVASNTTTKRTGLPN
EFSSLHGGLSGPMLKERSLEMLKILRRDLPKNKFCIISVGGVWDYTDVLE
RLEYGADLVQGYTAFVYNGPYWASNINRDLSRLRS
>TWT364 pyrF, orotidine-5'-phosphate decarboxylase
MISFGDRLQNAFTDFGHLCVGIDPHEWILEQWGLPNSPAGAQEFALRILD
LSSECVGLYKVQVAFYERFGSKGIFALEEVISAIRSTGALVIADGKRGDI
ASTMSGYAKAWLCRDSRLFSDALTVSPYVGLGSFKGSIDIARQNGAGLFF
LAATSEMHAFPIQSAILQDRQGIFGESSGSILSCSDITVASYIFESIGTL
VGNPSDCSSFGVVLSATSDLLSLGIGCNLSEFSRVMPILAPGFGYQGVEL
KDSRKRFGSLISNLIISESRSLLASGPRRFSALVNTRSEELRSLFDDSHE
NAG
>TWT100 pyrG, CTP synthase
MNGIKHIFITGGVVSSIGKGLTAASLGSLLTMRGLKVFIKKLDPYLNVDP
GTMNPLQHGEVFITEDGAETDLDVGHYERFLDVDLDRTANVTTGQVYSKV
ITLERTGRYLGETVQVIPHITDEIKRRIRLAPDDIDVIITEIGGTVGDIE
SQPFIEAARQIRREVGRENCCFIHVSLVPFLESAGEQKTKPTQHSVAILR
AAGIQPDALVLRSDKPISSANQKKIALMCDVSAVVNAVTVPNIYEIPCVL
NQHGLDKFVIKHLDLEAGEIDWSYWDDVLDAIENNRSEIEIAIIGKYTGL
PDAYISVIEALRAGGFESKTKVNIKWVDSDDENLEDQLENINGACIPGGF
GIRGIEGLIKAIRICREREIPTLGICLGMQCMVIEYARHVVGMHGASSTE
FTDDTQWPVVTTMLEQRDILIDDQFGGTMRLGSYRAVLSIGSLAASLYGT
TDIHERHRHRYEVNNGYAQRLVERGLIVSGRNTEQDLIEFIELDRKDHPF
YIGTQAHPECKSRPKRPHPLFKGLVAAALARKEIAEFNSGKTVLQ
>TWT447 pyrH, uridylate kinase
MASRRVLLKLSGESFGGGAPLVDPDVVSAIASEIVRVSKTIQIAIVVGGG
NYFRGAELSRRGMARDRADYMGMLGTVINALALQDFLEQAGGDTRVQSAI
SMSQVAELYVPRRAERHLTKGRVVIFAAGAGMPYFSTDTVAVQRALEIKA
DIVLIAKNGVDGVYTDDPQINPNAKKIYKITYREALERGLRVVDSAALGL
CMEHGLPMRVFGMESLRDAVSGLKVGTELSQ
>TWT616 thyX, thymidylate synthase
MLQCLFFVMDPVFLSEITVELVKHSASDSDVVFSARVSTLGSFVAVTDCL
SNRDIGLITFLMRERHGSPFEHSHMTFRISAPIFVFREFMRHRIASYNEE
SGRYKNLDPVFYIPDEKRKLVQIGAPGAYKFEEGTSEQYGLLIEEMKELS
LAAYDTYKRLLACGIAREVARMILPLNLYSTMYVTINARSLMNFLSVRTS
RANSAFHSYPQREIELCADRIEEIWKGLMPETHAAFEKQGRVAP
>TWT695 tmk, thymidylate kinase
MFVTFEGIDGSGKTAQLTAAGEFLKASGKQVVLTREPGTISCIRDYVLAS
DMDIRTEALLYSADRAENIAKNVIPALNAGKVVLQDRYLDSFLAYQLADN
KLVETDIMRLFEFSSQGLRPDLTLLFDLTPACAQERLENRDRIERKPIDF
HSKVRNIYLKLSADNTDRIRVIDASQSFSKIHQQVIYHIERKLGGTHSA
>TWT743 umpA, orotate phosphoribosyltransferase
MQRILDLRRIYALTVDPRTLHGSVWKVDFKVVRQELIRYIKDLALFEGEF
ILSSGQKSSYYIDLRRVSLDCRAAPIIGKVMFDLICDLQDVDAIGGLTMG
ADPIACAIMHYAASVGRSYNAFVVRKQKKTHGLARLIEGPDIRGKRVVIV
EDTSTTGNSPITAARRAEETGATVAAIAVMVDRETGARQAIEKAGYSYYA
ALRVTDILDRGTAD